28,717 results match your criteria Lead Encephalopathy


A Treatable Encephalopathy in a Peritoneal Dialysis Patient - Cefepime-Induced Encephalopathy.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):324-326

Neurology Unit, Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

We report a patient with end-stage renal disease on peritoneal dialysis, who developed encephalopathy after receiving a few doses of cefepime. He recovered clinically and electroencephalographically after having discontinued the culprit agent and undergone hemodialysis. This case highlights the importance of promptly recognizing this reversible encephalopathy, which can lead to the avoidance of unnecessary workup, reduce the length of hospital stay, and thereby improve the patients' outcome. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/324/254
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http://dx.doi.org/10.4103/jnrp.jnrp_315_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454930PMC
April 2019
2 Reads

Gut microbiome interventions in human health and diseases.

Med Res Rev 2019 Apr 17. Epub 2019 Apr 17.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, China.

Ongoing studies have determined that the gut microbiota is a major factor influencing both health and disease. Host genetic factors and environmental factors contribute to differences in gut microbiota composition and function. Intestinal dysbiosis is a cause or a contributory cause for diseases in multiple body systems, ranging from the digestive system to the immune, cardiovascular, respiratory, and even nervous system. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/med.21584
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http://dx.doi.org/10.1002/med.21584DOI Listing
April 2019
2 Reads

Comparing erosion and organ accumulation rates of lead and alternative lead-free ammunition fed to captive domestic ducks.

Ambio 2019 Apr 16. Epub 2019 Apr 16.

Institute of Animal Nutrition (ITE), Bundesallee 37, 38116, Braunschweig, Germany.

Lead poisoning of birds of prey from ingestion of ammunition lead has been well documented. Alternative, lead-free ammunition is widely available, but the toxicokinetics of other metals in birds are poorly understood. We tested the erosion of lead, copper, zinc, iron and brass by feeding domestic Pekin ducks (Anas platyrhynchos forma domestica) defined numbers of small metal pellets. Read More

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http://dx.doi.org/10.1007/s13280-019-01183-0DOI Listing
April 2019
1 Read

IMM-H004 Protects against Cerebral Ischemia Injury and Cardiopulmonary Complications via CKLF1 Mediated Inflammation Pathway in Adult and Aged Rats.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces & College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

(1) Background: Chemokine-like factor 1 (CKLF1) is a chemokine with potential to be a target for stroke therapy. Compound IMM-H004 is a novel coumarin derivative screened from a CKLF1/C-C chemokine receptor type 4 (CCR4) system and has been reported to improve cerebral ischemia/reperfusion injury. This study aims to investigate the protective effects of IMM-H004 on cerebral ischemia injury and its infectious cardiopulmonary complications in adult and aged rats from the CKLF1 perspective. Read More

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http://dx.doi.org/10.3390/ijms20071661DOI Listing
April 2019
1 Read

Acylcarnitine profile in neonatal hypoxic-ischemic encephalopathy: The value of butyrylcarnitine as a prognostic marker.

Medicine (Baltimore) 2019 Apr;98(15):e15221

Neonatal Unit, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela.

Optimal prognostic markers evaluating early neuroprotective interventions in neonatal hypoxic-ischemic encephalopathy (HIE) are lacking. This study was designed to assess the prognostic value of acylcarnitines in neonatal HIE.An observational cohort study was conducted over 10 years in 67 HIE. Read More

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http://dx.doi.org/10.1097/MD.0000000000015221DOI Listing
April 2019
1 Read

Gadolinium Deposition in Neurology Clinical Practice.

Ochsner J 2019 ;19(1):17-25

Department of Neurology, Ochsner Clinic Foundation, New Orleans, LA.

Magnetic resonance imaging (MRI) enhanced with gadolinium-based contrast agents (GBCAs) is an essential tool in the diagnosis and management of many neurologic diseases, including multiple sclerosis, brain tumors, and infections. The clinical utility of GBCAs is evidenced by their widespread use. GBCAs are produced in macrocyclic and linear forms. Read More

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http://dx.doi.org/10.31486/toj.18.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447198PMC
January 2019

Overlap of polymicrogyria, hydrocephalus, and Joubert syndrome in a family with novel truncating mutations in ADGRG1/GPR56 and KIAA0556.

Neurogenetics 2019 Apr 13. Epub 2019 Apr 13.

Institute for Neuroscience, Department of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, Washington, 20037, DC, USA.

Genetic mutations associated with brain malformations can lead to a spectrum of severity and it is often difficult to determine whether there are additional pathogenic variants contributing to the phenotype. Here, we present a family affected by a severe brain malformation including bilateral polymicrogyria, hydrocephalus, patchy white matter signal changes, and cerebellar and pontine hypoplasia with elongated cerebellar peduncles leading to the molar tooth sign. While the malformation is reminiscent of bilateral frontoparietal polymicrogyria (BFPP), the phenotype is more severe than previously reported and also includes features of Joubert syndrome (JBTS). Read More

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http://dx.doi.org/10.1007/s10048-019-00577-2DOI Listing
April 2019
2.884 Impact Factor

Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice.

Brain Behav Immun 2019 Apr 11. Epub 2019 Apr 11.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea; Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore. Electronic address:

Aggregation of the microtubule-associated protein, tau, can lead to neurofibrillary tangle formation in neurons and glia which is the hallmark of tauopathy. The cellular damage induced by the formation of neurofibrillary tangles leads to neuroinflammation and consecutive neuronal death. However, detailed observation of transcriptomic changes under tauopathy together with the comparison of age-dependent progression of neuroinflammatory gene expressions mediated by tau overexpression is required. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.04.011DOI Listing

Upregulation of CBP by PLY can cause permeability of blood-brain barrier to increase meningitis.

J Biochem Mol Toxicol 2019 Apr 12:e22333. Epub 2019 Apr 12.

Department of Encephalopathy, Oriental Hospital of Beijing University of Chinese Medicine, Beijing, People's Republic of China.

Background: Streptococcus pneumoniae causes many human diseases including bacterial meningitis. Previous study proposed that pneumolysin (PLY), a cytotoxin from pneumococcus, is related to the infection across blood-brain barrier (BBB). However, the mechanism of how PLY break through BBB remains elusive. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22333
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http://dx.doi.org/10.1002/jbt.22333DOI Listing
April 2019
3 Reads

The potential roles of aquaporin 4 in amyotrophic lateral sclerosis.

Neurol Sci 2019 Apr 13. Epub 2019 Apr 13.

Computer Center, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China.

Aquaporin 4 (AQP4) is a primary water channel found on astrocytes in the central nervous system (CNS). Besides its function in water and ion homeostasis, AQP4 has also been documented to be involved in a myriad of acute and chronic cerebral pathologies, including autoimmune neurodegenerative diseases. AQP4 has been postulated to be associated with the incidence of a progressive neurodegenerative disorder known as amyotrophic lateral sclerosis (ALS), a disease that targets the motor neurons, causing muscle weakness and eventually paralysis. Read More

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http://link.springer.com/10.1007/s10072-019-03877-5
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http://dx.doi.org/10.1007/s10072-019-03877-5DOI Listing
April 2019
2 Reads

α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1.

Aging Cell 2019 Apr 11:e12922. Epub 2019 Apr 11.

School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.

α-Synuclein (aSyn) toxicity is associated with cell cycle alterations, activation of DNA damage responses (DDR), and deregulation of autophagy. However, the relationships between these phenomena remain largely unknown. Here, we demonstrate that in a yeast model of aSyn toxicity and aging, aSyn expression induces Ras2-dependent growth signaling, cell cycle re-entry, DDR activation, autophagy, and autophagic degradation of ribonucleotide reductase 1 (Rnr1), a protein required for the activity of ribonucleotide reductase and dNTP synthesis. Read More

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http://dx.doi.org/10.1111/acel.12922DOI Listing
April 2019
1 Read

Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice.

Cell Death Dis 2019 Apr 11;10(4):323. Epub 2019 Apr 11.

School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil.

Harmful environmental stimuli during critical stages of development can profoundly affect behavior and susceptibility to diseases. Alzheimer disease (AD) is the most frequent neurodegenerative disease, and evidence suggest that inflammatory conditions act cumulatively, contributing to disease onset. Here we investigated whether infection early in life can contribute to synapse damage and cognitive impairment induced by amyloid-β oligomers (AβOs), neurotoxins found in AD brains. Read More

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http://dx.doi.org/10.1038/s41419-019-1529-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459845PMC
April 2019
1 Read

Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke.

Neuroreport 2019 Apr 8. Epub 2019 Apr 8.

Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardiocerebrovascular Diseases, Institute of New Drug Research, Jinan University College of Pharmacy.

Neuronal death is among the deleterious pathological changes that occur after cerebral ischemia and can lead to transient or permanent neurological deficits. The tetramethylpyrazine analog T-006 has been shown to be a multifunctional neuroprotective agent; however, its neuroprotective effect and mechanism of action have not been studied in ischemic stroke model rats. This study investigated the neuroprotective effects of T-006 in rat stroke model using a battery of behavioral and molecular biological tests. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001256DOI Listing
April 2019
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Preventive role of Resveratrol against inflammatory cytokines and related diseases

Curr Pharm Des 2019 04 10. Epub 2019 Apr 10.

Department of Pharmaceutical Sciences, School of Life Sciences, North South University, Dhaka-1229, Bangladesh.

Background: Immunity is the ultimate barrier between foreign stimuli and a host cell. Unwanted immune responses can threaten the host cells and may eventually damage a vital organ. Overproduction of inflammatory cytokines may also lead to autoimmune diseases. Read More

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http://dx.doi.org/10.2174/1381612825666190410153307DOI Listing
April 2019
2 Reads

Molecular docking of natural phenolic compounds for screening of urease inhibitors.

Curr Pharm Biotechnol 2019 Apr 9. Epub 2019 Apr 9.

International Institute of Pharmaceutical Sciences, Sonepat, Haryana. India.

Bacterial ureases have been the cause of various human and animal pathogenicity including hepatic encephalopathy, hepatic coma urolithiasis, gastric and peptic ulcers, pyelonephritis, and urinary catheter encrustation by production of ammonia. Hence in view of the side effects of existing drugs, there is a strong need to discover, more safe, effective and potent compounds for treatment of infections caused by urease. For this purpose, several natural phenolic compounds have been screened by molecular modelling techniques. Read More

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http://dx.doi.org/10.2174/1389201020666190409110948DOI Listing
April 2019
5 Reads
2.511 Impact Factor

Modelling human pathology of traumatic brain injury in animal models.

J Intern Med 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurobiology, Care Science and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.

Traumatic brain injury (TBI) is caused by a head impact with a force exceeding regular exposure from normal body movement which the brain normally can accommodate. People affected include, but are not restricted to, sport athletes in American football, ice hockey, boxing as well as military personnel. Both single and repetitive exposures may affect the brain acutely and can lead to chronic neurodegenerative changes including chronic traumatic encephalopathy (CTE) associated with the development of dementia. Read More

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http://dx.doi.org/10.1111/joim.12909DOI Listing
April 2019
1 Read

[Differentiating cochlear synaptopathies into different hearing disorders].

HNO 2019 Apr 8. Epub 2019 Apr 8.

Universitätsklinik für Hals-Nasen-Ohren-Heilkunde, Plastische Operationen, Sektion Molekulare Hörphysiologie, Hörforschungszentrum Tübingen (THRC), Elfriede-Aulhorn-Straße 5, 72076, Tübingen, Deutschland.

Due to demographic change and altered recreational behavior, a rapid increase in hearing deficits is expected in the next 20-30 years. Consequently, the risk of age-related loss of speech discrimination, tinnitus, hyperacusis, or-as recently shown-dementia, will also increase. There are increasing indications that the loss of specific hearing fibers in humans and animals is involved in various hearing disorders. Read More

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http://dx.doi.org/10.1007/s00106-019-0660-4DOI Listing
April 2019
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A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques.

Nat Biomed Eng 2019 Mar 11;3(3):206-219. Epub 2019 Feb 11.

Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan.

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that lack therapeutic solutions. Here, we show that the molecular chaperone (N,N'-([cyclohexylmethylene]di-4,1-phenylene)bis(2-[1-pyrrolidinyl]acetamide)), designed via docking simulations, molecular dynamics simulations and quantum chemical calculations, slows down the progress of TSEs. In vitro, the designer molecular chaperone stabilizes the normal cellular prion protein, eradicates prions in infected cells, prevents the formation of drug-resistant strains and directly inhibits the interaction between prions and abnormal aggregates, as shown via real-time quaking-induced conversion and in vitro conversion NMR. Read More

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http://dx.doi.org/10.1038/s41551-019-0349-8DOI Listing
March 2019
1 Read

Portal Hypertension and Related Complications: Diagnosis and Management.

Mayo Clin Proc 2019 Apr;94(4):714-726

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

Portal hypertension is a major complication of cirrhosis, and its consequences, including ascites, esophageal varices, hepatic encephalopathy, and hepatorenal syndrome, lead to substantial morbidity and mortality. The past several decades have seen major improvements in the clinical management of complications of portal hypertension, resulting in substantial gains in patient outcomes. However, important challenges remain. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.12.020DOI Listing
April 2019
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Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases.

J Med Chem 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmaceutical Sciences, College of Pharmacy , University of Nebraska Medical Center , Omaha , Nebraska 68198-6125 , United States.

Transient receptor potential canonical (TRPC) channels are highly homologous, nonselective cation channels that form many homo- and heterotetrameric channels. These channels are highly abundant in the brain and kidney and have been implicated in numerous diseases, such as depression, addiction, and chronic kidney disease, among others. Historically, there have been very few selective modulators of the TRPC family in order to fully understand their role in disease despite their physiological significance. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01954DOI Listing
April 2019
3 Reads

Elimination, not reduction: Lessons from the Research Domain Criteria (RDoC) and multiple realisation.

Authors:
Tuomas K Pernu

Behav Brain Sci 2019 01;42:e22

Department of Philosophy,King's College London,London,WC2R 2LS,United

The thesis of multiple realisation that Borsboom et al. are relying on should not be taken for granted. In dissolving the apparent multiple realisation, the reductionist research strategies in psychopathology research (the Research Domain Criteria [RDoC] framework, in particular) are bound to lead to eliminativism rather than reductionism. Read More

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http://dx.doi.org/10.1017/S0140525X18001139DOI Listing
January 2019

Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice.

J Neuroinflammation 2019 Apr 2;16(1):69. Epub 2019 Apr 2.

Central Texas Veterans Health Care System, Temple, TX, USA.

Background: Acute liver failure resulting from drug-induced liver injury can lead to the development of neurological complications called hepatic encephalopathy (HE). Hepatic transforming growth factor beta 1 (TGFβ1) is upregulated due to liver failure in mice and inhibiting circulating TGFβ reduced HE progression. However, the specific contributions of TGFβ1 on brain cell populations and neuroinflammation during HE are not known. Read More

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http://dx.doi.org/10.1186/s12974-019-1455-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446280PMC
April 2019
2 Reads

Variant Creutzfeldt-Jakob disease strain is identical in individuals of two PRNP codon 129 genotypes.

Brain 2019 Apr 1. Epub 2019 Apr 1.

The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, UK, EH25 9RG.

In 2004, a subclinical case of variant Creutzfeldt-Jakob disease in a PRNP 129 methionine/valine heterozygous individual infected via blood transfusion was reported, and we established that the spleen from this individual was infectious. Since host genetics is an important factor in strain modification, the identification of variant Creutzfeldt-Jakob disease infection in a PRNP 129 methionine/valine heterozygous individual has raised the possibility that the properties of the variant Creutzfeldt-Jakob disease agent could change after transmission to this different genetic background and concerns that this could lead to a more virulent strain of variant Creutzfeldt-Jakob disease. The variant Creutzfeldt-Jakob disease strain has to date been characterized only in methionine homozygous individuals, therefore to establish whether the strain characteristics of variant Creutzfeldt-Jakob disease had been modified by the host genotype, spleen material with prion protein deposition from a PRNP 129 methionine/valine individual was inoculated into a panel of wild-type mice. Read More

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http://dx.doi.org/10.1093/brain/awz076DOI Listing
April 2019
1 Read

Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity.

Brain 2019 Apr 1. Epub 2019 Apr 1.

Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Amyotrophic lateral sclerosis is a deleterious neurodegenerative disease without effective treatment options. Recent studies have indicated the involvement of the dysregulation of RNA metabolism in the pathogenesis of amyotrophic lateral sclerosis. Among the various RNA regulatory machineries, nonsense-mediated mRNA decay (NMD) is a stress responsive cellular surveillance system that degrades selected mRNA substrates to prevent the translation of defective or harmful proteins. Read More

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http://dx.doi.org/10.1093/brain/awz070DOI Listing
April 2019
3 Reads

Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug Discovery and Therapy.

Front Pharmacol 2019 7;10:204. Epub 2019 Mar 7.

Center of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau, China.

Acquired brain ischemia-and reperfusion-injury (IRI), including both Ischemic stroke (IS) and Traumatic Brain injury (TBI), is one of the most common causes of disability and death in adults and represents a major burden in both western and developing countries worldwide. China's clinical neurological therapeutic experience in the use of traditional Chinese medicines (TCMs), including TCM-derived active compounds, Chinese herbs, TCM formulations and decoction, in brain IRI diseases indicated a trend of significant improvement in patients' neurological deficits, calling for blind, placebo-controlled and randomized clinical trials with careful meta-analysis evaluation. There are many TCMs in use for brain IRI therapy in China with significant therapeutic effects in preclinical studies using different brain IRI-animal. Read More

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http://dx.doi.org/10.3389/fphar.2019.00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423897PMC
March 2019
1 Read

Toll-like receptors in the pathogenesis of neuroinflammation.

Authors:
V Kumar

J Neuroimmunol 2019 Mar 20;332:16-30. Epub 2019 Mar 20.

Children Health Clinical Unit, School of Clinical Medicine, Faculty of Medicine, Mater Research, University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia. Electronic address:

Toll-like receptors (TLRs) are discovered as crucial pattern recognition receptors (PRRs) involved in the recognition of pathogen-associated molecular patterns (PAMPs). Later studies showed their involvement in the recognition of various damage/danger-associated molecular patterns (DAMPs) generated by host itself. Thus, TLRs are capable of recognizing wide-array of patterns/molecules derived from pathogens and host as well and initiating a proinflammatory immune response through the activation of NF-κB and other transcription factors causing synthesis of proinflammatory molecules. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.012DOI Listing
March 2019
1 Read

Structure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability.

Eur J Med Chem 2019 Jun 21;171:420-433. Epub 2019 Mar 21.

Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address:

(E)-3,4-dihydroxystyryl alkyl sulfones, as new analogues of neurodegenerative agents, were designed and synthesized. The biological results demonstrated that most of the target compounds preserved antioxidant and anti-inflammatory potency in scavenging reactive free radicals, protecting neuronal cells against neurotoxins such as HO, 6-hydroxydopamine and inhibiting lipopolysaccharide (LPS)-induced over-production of NO. Among these compounds, 6. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.044DOI Listing
June 2019
1 Read

Tissue metallothionein response in the Japanese quail associated with exposure to cyanobacterial biomass, lead and the Newcastle disease virus.

Neuro Endocrinol Lett 2019 Mar;39(8):567-571

Department of Ecology and Diseases of Game, Fish and Bees, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic.

Objectives: Here we tested the hypothesis that multiple toxic and infectious stressors combine in their adverse effects to produce higher tissue responses of metallothioneins (MTs) in birds.

Methods: We used Japanese quails as a model avian species. The study is based on data obtained from single and combined exposures of Japanese quails to cyanobacterial biomass containing microcystins, lead and a live Newcastle disease vaccination virus. Read More

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March 2019
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Cardiovascular functions of central corticotropin-releasing factor related peptides system.

Neuropeptides 2019 Mar 20. Epub 2019 Mar 20.

Department of Pediatrics, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, China.

The corticotropin-releasing factor (CRF) related peptides system has widespread distributions in central nervous system, to perform many physiological and pathophysiological functions, including cardiovascular functions. A complex connection exists between the central CRF related peptides system and cardiovascular system. There are multiple pathways and mechanisms through which the central CRF related peptides system influences cardiovascular functions. Read More

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http://dx.doi.org/10.1016/j.npep.2019.03.006DOI Listing

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis.

Mol Neurodegener 2019 03 27;14(1):14. Epub 2019 Mar 27.

Center for Integrative Biology, Faculty of Science, Universidad Mayor, Camino la Piramide 5750, P.O.BOX 70086, Santiago, Chile.

Background: Amyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. Our study was aimed to uncover new connections within the ALS network through a bioinformatic approach, by which we identified C13orf18, recently named Pacer, as a new component of the autophagic machinery and potentially involved in ALS pathogenesis. Read More

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http://dx.doi.org/10.1186/s13024-019-0313-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437924PMC
March 2019
1 Read

Efficacy of orally administered sodium benzoate and sodium phenylbutyrate in dogs with congenital portosystemic shunts.

J Vet Intern Med 2019 Mar 27. Epub 2019 Mar 27.

Pharmacy Department, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Hyperammonemia can result in hepatic encephalopathy, which in severe cases eventually can lead to coma and death. In dogs, congenital portosystemic shunts (CPSS) are the most common cause for hyperammonemia. Conservative treatment consists of a protein modified diet, nonabsorbable disaccharides, antibiotics, or some combinations of these. Read More

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http://dx.doi.org/10.1111/jvim.15477DOI Listing

Cross-Frequency Coupling Between Cerebral Blood Flow Velocity and EEG in Ischemic Stroke Patients With Large Vessel Occlusion.

Front Neurol 2019 12;10:194. Epub 2019 Mar 12.

Neurointensive Care Unit, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Neurovascular coupling enables a rapid adaptation of cerebral blood flow (CBF) to support neuronal activities. Whether this mechanism is compromised during the acute phase after ischemic stroke remains unknown. In this study, we applied a phase-amplitude cross-frequency coupling (PAC) algorithm to investigate multimodal neuro signals including CBF velocity (CBFV), and electroencephalography (EEG). Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00194
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http://dx.doi.org/10.3389/fneur.2019.00194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422917PMC
March 2019
9 Reads

TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies.

Front Pharmacol 2019 12;10:239. Epub 2019 Mar 12.

School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

Microglial cells in the central nervous system (CNS) are crucial in maintaining a healthy environment for neurons to function properly. However, aberrant microglial cell activation can lead to excessive generation of neurotoxic proinflammatory mediators and neuroinflammation, which represents a contributing factor in a wide spectrum of CNS pathologies, including ischemic stroke, traumatic brain damage, Alzheimer's disease, Parkinson's disease, multiple sclerosis, psychiatric disorders, autism spectrum disorders, and chronic neuropathic pain. Oxidative stress is a salient and common feature of these conditions and has been strongly implicated in microglial cell activation and neuroinflammation. Read More

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http://dx.doi.org/10.3389/fphar.2019.00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423084PMC
March 2019
1 Read

Unfolding Pathways of Hen Egg-White Lysozyme in Ethanol.

J Phys Chem B 2019 Apr 4;123(15):3267-3271. Epub 2019 Apr 4.

Department of Chemistry , University of North Texas , Denton , Texas 76201 , United States.

The aggregation of amyloid fibrils can lead to various diseases including Alzheimer's, Parkinson's disease, and transmissible spongiform encephalopathy. Amyloid fibrils can develop from a variety of proteins in the body as they misfold into a primarily β-sheet structure and aggregate. Human lysozyme has been shown to have far reaching effects in the human health-a homologous enzyme, hen egg-white lysozyme, has been shown to denature to a primarily β-sheet structure at low pH and high alcohol content solution. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b01694DOI Listing

Peripheral blood test provides a practical method for glioma evaluation and prognosis prediction.

CNS Neurosci Ther 2019 Mar 26. Epub 2019 Mar 26.

Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Objective: To investigate the relationship between tumor characteristics and the preoperative counts of immune cells in peripheral blood test in glioma patients.

Methods: We included 260 WHO grades II-IV patients who had preoperative peripheral blood test result from Sanbo hospital as training set. The 66 patients from Tiantan hospital was obtained for validation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cns.13120
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http://dx.doi.org/10.1111/cns.13120DOI Listing
March 2019
8 Reads
3.931 Impact Factor

Cognitive training for people with mild to moderate dementia.

Cochrane Database Syst Rev 2019 03 25;3:CD013069. Epub 2019 Mar 25.

Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, 34-54 Poplar Road, Parkville, Melbourne, Victoria, Australia, 3052.

Background: Cognitive impairment, a defining feature of dementia, plays an important role in the compromised functional independence that characterises the condition. Cognitive training (CT) is an approach that uses guided practice on structured tasks with the direct aim of improving or maintaining cognitive abilities.

Objectives: • To assess effects of CT on cognitive and non-cognitive outcomes for people with mild to moderate dementia and their caregivers. Read More

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http://dx.doi.org/10.1002/14651858.CD013069.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433473PMC
March 2019
2 Reads

Lead exposure-induced cognitive impairment through RyR-modulating intracellular calcium signaling in aged rats.

Toxicology 2019 May 21;419:55-64. Epub 2019 Mar 21.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China; Jiangxi provincial key laboratory of preventive medicine, Nanchang University, Nanchang, 330006, China; Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, 330006, China. Electronic address:

Lead is widely distributed in the environment and has become a global public health issue. It is well known that lead exposure induces not only neurodevelopmental toxicity but also neurodegenerative diseases, with learning and memory impairment in the later stage. However, the molecular mechanisms remain elusive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X183066
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http://dx.doi.org/10.1016/j.tox.2019.03.005DOI Listing
May 2019
5 Reads

Motile ciliogenesis and the mitotic prism.

Biol Cell 2019 Mar 24. Epub 2019 Mar 24.

Institut de Biologie de l'École Normale Supérieure (IBENS), Paris Sciences et Lettres (PSL) Research University, Paris, F-75005, France.

Motile cilia of epithelial multiciliated cells transport vital fluids along organ lumens to promote essential respiratory, reproductive and brain functions. Progenitors of multiciliated cells undergo massive and coordinated organelle remodelling during their differentiation for subsequent motile ciliogenesis. Defects in multiciliated cell differentiation lead to severe cilia-related diseases by perturbing cilia-based flows. Read More

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http://dx.doi.org/10.1111/boc.201800072DOI Listing

Mild phenotype in Molybdenum cofactor deficiency: A new patient and review of the literature.

Mol Genet Genomic Med 2019 Mar 21:e657. Epub 2019 Mar 21.

Pediatric Neurology Unit, V. Buzzi Children's Hospital, Milan, Italy.

Background: Molybdenum cofactor deficiency (MoCD) is a rare autosomal-recessive disorder that results in the combined deficiency of molybdenum-dependent enzymes. Four different genes are involved in Molybdenum cofactor biosynthesis: MOCS1, MOCS2, MOCS3, and GEPH. The classical form manifests in the neonatal period with severe encephalopathy, including intractable seizures, MRI changes that resemble hypoxic-ischemic injury, microcephaly, and early death. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.657
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http://dx.doi.org/10.1002/mgg3.657DOI Listing
March 2019
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Mysm1 epigenetically regulates the immunomodulatory function of adipose-derived stem cells in part by targeting miR-150.

J Cell Mol Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Neural Engineering and Biological Interdisciplinary Studies, Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Beijing, P.R. China.

Adipose-derived stem cells (ASCs) are highly attractive for cell-based therapies in tissue repair and regeneration because they have multilineage differentiation capacity and are immunosuppressive. However, the detailed epigenetic mechanisms of their immunoregulatory capacity are not fully defined. In this study, we found that Mysm1 was induced in ASCs treated with inflammatory cytokines. Read More

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http://dx.doi.org/10.1111/jcmm.14281DOI Listing
March 2019
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Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.

Nature 2019 Apr 20;568(7752):420-423. Epub 2019 Mar 20.

MRC Laboratory of Molecular Biology, Cambridge, UK.

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is associated with repetitive head impacts or exposure to blast waves. First described as punch-drunk syndrome and dementia pugilistica in retired boxers, CTE has since been identified in former participants of other contact sports, ex-military personnel and after physical abuse. No disease-modifying therapies currently exist, and diagnosis requires an autopsy. Read More

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http://dx.doi.org/10.1038/s41586-019-1026-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472968PMC
April 2019
1 Read

Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 12;236:84-93. Epub 2019 Mar 12.

Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands; Korsakoff Center Slingedael, Lelie Care Group, Rotterdam, the Netherlands.

Pregnant women have an increased demand for thiamine. In hyperemesis gravidarum (HG) thiamine rapidly depletes, which can lead to Wernicke's Encephalopathy (WE). Our objective was to systematically review the signs and symptoms of WE in HG. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.006DOI Listing
March 2019
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Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System.

Front Immunol 2019 4;10:362. Epub 2019 Mar 4.

UK Dementia Research Institute, Cardiff University, Cardiff, United Kingdom.

The complement system plays critical roles in development, homeostasis, and regeneration in the central nervous system (CNS) throughout life; however, complement dysregulation in the CNS can lead to damage and disease. Complement proteins, regulators, and receptors are widely expressed throughout the CNS and, in many cases, are upregulated in disease. Genetic and epidemiological studies, cerebrospinal fluid (CSF) and plasma biomarker measurements and pathological analysis of post-mortem tissues have all implicated complement in multiple CNS diseases including multiple sclerosis (MS), neuromyelitis optica (NMO), neurotrauma, stroke, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409326PMC
March 2019
1 Read

Emphysema: A Potential Risk Factor for Subarachnoid Hemorrhage and Ruptured Aortic Aneurysm

Stroke 2019 04;50(4):992-994

Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (A.E.M., J.E.B., H.K.), Weill Cornell Medicine, New York, NY.

Background and Purpose- Protease/antiprotease imbalance is implicated in the pathogenesis of emphysema and may also lead to vessel wall weakening, aneurysm development, and rupture. However, it is unclear whether emphysema is associated with cerebral and aortic aneurysm rupture. Methods- We performed a retrospective cohort study using outpatient and inpatient claims data from 2008 to 2014 from a nationally representative sample of Medicare beneficiaries ≥66 years of age. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433532PMC
April 2019
2 Reads

Heterogeneous clinical phenotypes and cerebral malformations reflected by rotatin cellular dynamics.

Brain 2019 Apr;142(4):867-884

Department of Clinical Genetics, Erasmus University Medical Center (Erasmus MC), CA Rotterdam, The Netherlands.

Recessive mutations in RTTN, encoding the protein rotatin, were originally identified as cause of polymicrogyria, a cortical malformation. With time, a wide variety of other brain malformations has been ascribed to RTTN mutations, including primary microcephaly. Rotatin is a centrosomal protein possibly involved in centriolar elongation and ciliogenesis. Read More

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http://dx.doi.org/10.1093/brain/awz045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439326PMC
April 2019
2 Reads

Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review.

Eur J Med Chem 2019 May 8;169:185-199. Epub 2019 Mar 8.

Department of Chemistry, Dasaratha Deb Memorial College, Khowai, Tripura, 799201, India.

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related neurodegenerative disorders, affecting several millions of aged people globally. Among these disorders, AD is more severe, affecting about 7% of individuals aged 65 and above. AD is primarily a dementia-related disorder from progressive cognitive deterioration and memory impairment, while PD is primarily a movement disorder illness having three major kinesia or movement disorder symptoms, bradykinesia (slowness of movements), hypokinesia (reduction of movement amplitude), and akinesia (absence of normal unconscious movements) along with muscle rigidity and tremor at rest. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.009DOI Listing
May 2019
16 Reads

[Technical characteristics of Alzheimer model based on organ technology (organoid)].

Hell J Nucl Med 2019 Jan-Apr;22 Suppl:195-208

Laboratory of Biochemistry, Dept. of Chemistry, Aristotle University, 54124, Thessaloniki, Greece.

Alzheimer's disease (AD) is a serious neurodegenerative disorder that manifests itself as progressive damage to memory and knowledge and is the main cause of dementia in the elderly. AD is characterized by extracellular deposition of amyloid-β plate (Aβ) and by the formation of neurofibrillary tangles, composed of hyperphosphorylated Tau protein. These modifications lead to neuronal cell death, vascular dysfunction and inflammatory disorders. Read More

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January 2019
5 Reads

Modulation of Ca2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity.

Mol Cell Neurosci 2019 Apr 12;96:35-46. Epub 2019 Mar 12.

Institute for Neurophysiology, University of Cologne, Germany. Electronic address:

Elevated levels of unbound unconjugated bilirubin (UCB) can lead to bilirubin encephalopathy and kernicterus. In spite of a large number of studies demonstrating UCB-induced changes in central neurotransmission, it is still unclear whether these effects involve alterations in the function of specific ion channels. To assess how different UCB concentrations and UCB:albumin (U/A) molar ratios affect neuronal R-type voltage-gated Ca channels, we evaluated their effects on whole-cell currents through recombinant Ca2. Read More

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http://dx.doi.org/10.1016/j.mcn.2019.03.003DOI Listing
April 2019
1 Read
3.840 Impact Factor