83,013 results match your criteria Le Fort Fractures


First field efficacy trial of the ChAd63 MVA ME-TRAP vectored malaria vaccine candidate in 5-17 months old infants and children.

PLoS One 2018 12;13(12):e0208328. Epub 2018 Dec 12.

Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.

Background: Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified Vaccinia Virus Ankara (MVA) vectored vaccines is a strategy previously shown to provide substantial protective efficacy against P. falciparum infection in United Kingdom adult Phase IIa sporozoite challenge studies (approximately 20-25% sterile protection with similar numbers showing clear delay in time to patency), and greater point efficacy in a trial in Kenyan adults.

Methodology: We conducted the first Phase IIb clinical trial assessing the safety, immunogenicity and efficacy of ChAd63 MVA ME-TRAP in 700 healthy malaria exposed children aged 5-17 months in a highly endemic malaria transmission area of Burkina Faso. Read More

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December 2018

Live nanoscopic to mesoscopic topography reconstruction with an optical microscope for chemical and biological samples.

PLoS One 2018 12;13(12):e0207881. Epub 2018 Dec 12.

LAI, Aix Marseille Univ, CNRS, INSERM, Marseille, France.

Macroscopic properties of physical and biological processes like friction, wetting, and adhesion or cell migration are controlled by interfacial properties at the nanoscopic scale. In an attempt to bridge simultaneously investigations at different scales, we demonstrate here how optical microscopy in Wet-Surface Ellipsometric Enhanced Contrast (Wet-SEEC) mode offers imaging and measurement of thin films at solid/liquid interfaces in the range 1-500 nm with lateral optical resolution. A live, label-free and noninvasive methodology integrated with microfluidic devices allowed here characterization of polymers and proteins patterns together with corresponding phenotypes of living cells. Read More

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December 2018

Combination of ST2 and B-type natriuretic peptide in diabetic patients with acute heart failure: relation with ventricular stiffness and outcome.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Cardiovascular Diseases Unit, Department of Internal Medicine, Le Scotte Hospital, University of Siena.

Background: Diabetes is a common disease in heart failure and its prevalence ranges from 10 to 30%. ST-2 is a novel biomarker of myocardial fibrosis and remodelling in heart failure and may be involved in the inflammatory process of diabetes mellitus. In this study, we sought: to evaluate levels of ST-2 and B-type natriuretic peptide (BNP) in groups with acute heart failure with and without diabetes; to analyse the prognostic impact of ST-2 over a 6-month follow-up period. Read More

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December 2018

Using membrane partitioning simulations to predict permeability of forty-nine drug-like molecules.

J Chem Inf Model 2018 Dec 12. Epub 2018 Dec 12.

A simple descriptor calculated from molecular dynamics simulations of the membrane partitioning event is found to correlate well with experimental measurements of passive membrane permeation from the high throughput MDCK-LE assay using a dataset of 49 drug-like molecules. This descriptor approximates the energy cost of translocation across the hydrophobic membrane core (flip-flop), which for many molecules limits permeability. Performance is found to be superior in comparison to calculated properties such as clogP, clogD or polar surface area. Read More

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December 2018

Cobalt-Catalyzed Oxidative Phosphonylation of α-Amino Acid Derivatives and α-Amino Ketones for α-Aminophosphonates.

J Org Chem 2018 Dec 12. Epub 2018 Dec 12.

A novel and efficient direct oxidative phosphonylation of α-amino ketones and α-amino acid derivatives with dialkyl phosphites by the catalysis of a cobalt salt under air was disclosed. A variety of α-amino ketones and α-amino acid derivatives underwent the reaction well with dialkyl phosphites to produce the desired α-aminophosphonates. This protocol not only provides an alternative synthetic route for the preparation of diverse α-aminophosphonates, but also avoids the use of potentially explosive peroxide agents. Read More

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December 2018

Cardiac magnetic resonance T1 mapping. Part 2: Diagnostic potential and applications.

Eur J Radiol 2018 Dec 21;109:235-247. Epub 2018 Oct 21.

Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 19/P, 8036 Graz, Austria; Research & Development, Siemens Healthcare Diagnostics GmbH, Strassgangerstrasse 315, 8054 Graz, Austria. Electronic address:

Non-invasive identification and differentiation of myocardial diseases represents the primary objectives of cardiac magnetic resonance (CMR) longitudinal relaxation time (T1) and extracellular volume (ECV) mapping. Given the fact that myocardial T1 and ECV values overlap throughout and within left ventricular phenotypes, a central issue to be addressed is whether and to what extent myocardial T1 and ECV mapping provides additional or superior diagnostic information to standard CMR imaging, and whether native T1 mapping could be employed as a non-contrast alternative to late gadolinium enhancement (LE) imaging. The present review aims to summarize physiological and pathophysiological alterations in native T1 and ECV values and summarized myocardial T1 and ECV alterations associated with cardiac diseases to support the translation of research findings into routine CMR imaging. Read More

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December 2018

The Incremental Value of Right Ventricular Size and Strain in the Risk Assessment of Right Heart Failure Post - Left Ventricular Assist Device Implantation.

J Card Fail 2018 Dec 26;24(12):823-832. Epub 2018 Oct 26.

Division of Cardiovascular Medicine, Stanford University School of Medicine and Stanford Cardiovascular Institute, Palo Alto, California.

Background: Right heart failure (RHF) after left ventricular assist device (LVAD) implantation is associated with high morbidity and mortality. Existing risk scores include semiquantitative evaluation of right ventricular (RV) dysfunction. This study aimed to determine whether quantitative evaluation of both RV size and function improve risk stratification for RHF after LVAD implantation beyond validated scores. Read More

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December 2018

Management of Acute Gallstone Cholangitis after Roux-en-Y Gastric Bypass with Laparoscopic Transgastric Endoscopic Retrograde Cholangiopancreatography.

Obes Surg 2018 Dec 11. Epub 2018 Dec 11.

Service de Chirurgie Générale et Endocrinienne, CHU Lille, Hôpital Huriez, Rue Michel Polonowski, 59000, Lille, France.

Background: The incidence of biliary lithiasis is increased after bariatric surgery due to rapid weight loss [1]. Trans-oral endoscopic management in cases of common bile duct gallstone complication is not possible in patients with Roux-en-Y gastric bypass (RYGB) due to the modified anatomy. Access to the biliary tree after RYGB with a classical direct surgical approach of common bile duct and choledocoscopy can be used, but may be complicated in situations of acute cholangitis because of the fragility of common duct, or in cases of previous cholecystectomy. Read More

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December 2018

Regulatory T cells regulate the distribution of natural killer T cells through CD39 signal transduction in asthma.

Hum Cell 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, South Campus, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 2000 Jiangyue Road, Minhang District, Shanghai, 201112, People's Republic of China.

Natural killer T cells (NKT cells) and regulatory T cells (Treg cells) are two important immune regulatory cells which both play critical roles in asthma. Our previous experiments revealed that activation of Treg cells suppressed NKT cells in asthma. However, the possible regulatory effects and the mechanisms linking Treg cells and NKT cells remain poorly understood. Read More

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December 2018

Closed-loop vasopressor control: in-silico study of robustness against pharmacodynamic variability.

J Clin Monit Comput 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology and Perioperative Medicine, Davide Geffen School of Medicine, University of California Los Angeles UCLA, Los Angeles, CA, USA.

Initial feasibility of a novel closed-loop controller created by our group for closed-loop control of vasopressor infusions has been previously described. In clinical practice, vasopressor potency may be affected by a variety of factors including other pharmacologic agents, organ dysfunction, and vasoplegic states. The purpose of this study was therefore to evaluate the effectiveness of our controller in the face of large variations in drug potency, where 'effective' was defined as convergence on target pressure over time. Read More

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December 2018

Identification of salivary metabolites for oral squamous cell carcinoma and oral epithelial dysplasia screening from persistent suspicious oral mucosal lesions.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.

Objective: To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML).

Subjects And Methods: Whole unstimulated saliva samples were collected from age-, sex-, and race-matched patients who had a lesion in the oral cavity and for whom open biopsies were performed. The patients included OSCC (n = 6), OED (n = 10), and PSOML (n = 32). Read More

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December 2018

Biomarker-based corticosteroid adjustment in severe asthma: a modified Delphi consensus.

ERJ Open Res 2018 Oct 7;4(4). Epub 2018 Dec 7.

Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.

http://ow.ly/sTrf30my3jw. Read More

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October 2018

Osteoprotegerin Induces CD34 Differentiation in Endothelial Progenitor Cells.

Front Med (Lausanne) 2018 27;5:331. Epub 2018 Nov 27.

Inserm, UMR_S1140, Faculty of Pharmacy, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Endothelial progenitor cells (EPCs) are the main hypothetical cells that could give rise to vessels and in particular one subtype isolated from peripheral or cord bloods: endothelial colony forming cells (ECFCs). These ECFCs are clonogenic precursors committed to endothelial lineage and have robust vasculogenic properties. However, their low number and poor expansion properties when isolated from human adult bloods, currently limit their use as an autologous cell therapy product. Read More

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November 2018

Development and applications of oncolytic Maraba virus vaccines.

Oncolytic Virother 2018 26;7:117-128. Epub 2018 Nov 26.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada,

Oncolytic activity of the MG1 strain of the Maraba vesiculovirus has proven efficacy in numerous preclinical cancer models, and relied not only on a direct cytotoxicity but also on the induction of both innate and adaptive antitumor immunity. To further expand tumor-specific T-cell effector and long-lasting memory compartments, we introduced the MG1 virus in a prime-boost cancer vaccine strategy. To this aim, a replication-incompetent adenoviral [Ad] vector together with the oncolytic MG1 have each been armed with a transgene expressing a same tumor antigen. Read More

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November 2018

Speciation Analysis of Arsenic Compounds by HPLC-ICP-MS: Application for Human Serum and Urine.

J Anal Methods Chem 2018 13;2018:9462019. Epub 2018 Nov 13.

School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet, Hai Ba Trung, Hanoi 100000, Vietnam.

A high-performance liquid chromatography (HPLC) in combination with inductively coupled plasma mass spectrometry (ICP-MS) as an elemental specific detector was used for the speciation analysis of arsenic compounds in urine and serum samples from Vietnam. Five arsenic species including arsenite (As), arsenate (As), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenobetaine (AsB) were studied. A gradient elution of ammonium carbonate ((NH)CO), ethylenediaminetetraacetic acid disodium salt (NaEDTA), and methanol at pH 9. Read More

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November 2018

Ancestrality and Mosaicism of Giant Viruses Supporting the Definition of the Fourth TRUC of Microbes.

Front Microbiol 2018 27;9:2668. Epub 2018 Nov 27.

Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM); Microbes, Evolution, Phylogeny and Infection (MEΦI); Institut Hospitalo-Universitaire (IHU) - Méditerranée Infection, Marseille, France.

Giant viruses of amoebae were discovered in 2003. Since then, their diversity has greatly expanded. They were suggested to form a fourth branch of life, collectively named 'TRUC' (for "Things Resisting Uncompleted Classifications") alongside , , and . Read More

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November 2018

Transcriptional Signatures in Liver Reveal Metabolic Adaptations to Seasons in Migratory Blackheaded Buntings.

Front Physiol 2018 27;9:1568. Epub 2018 Nov 27.

IndoUS Center for Biological Timing, Department of Zoology, University of Delhi, New Delhi, India.

The molecular underpinnings of metabolic adaptation to seasons are poorly understood in long- distance migrants. We measured changes in physiology and performed sequencing of RNA extracted from liver samples collected at 4-h intervals over a period of 24 h from a long-distance avian migrant, the blackheaded bunting (), during two states: photostimulated vernal migratory (M) state and photorefractory non-migratory (nM) state. The M state was differentiated from the nM state based on body fattening and weight gain, as well as on , that is, nocturnal migratory restlessness in caged birds. Read More

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November 2018

Differential subcellular localization regulates oncogenic signaling by ROS1 kinase fusion proteins.

Cancer Res 2018 Dec 11. Epub 2018 Dec 11.

Medicine, University of California, San Francisco

Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often contain the C-terminal kinase domain of the RTK joined in cis to various N-terminal, non-kinase fusion partners. The functional role of the N-terminal fusion partner in RTK fusion oncoproteins is poorly understood. Read More

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December 2018

Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity.

Blood Adv 2018 Dec;2(23):3540-3552

Department of Medicine and.

Megakaryocyte (MK) migration from the bone marrow periosteal niche toward the vascular niche is a prerequisite for proplatelet extension and release into the circulation. The mechanism for this highly coordinated process is poorly understood. Here we show that dynasore (DNSR), a small-molecule inhibitor of dynamins (DNMs), or short hairpin RNA knockdown of DNM2 and DNM3 impairs directional migration in a human MK cell line or MKs derived from cultured CD34 cells. Read More

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December 2018

Improved Survival Outcomes for Kidney Cancer Patients With Brain Metastases.

Clin Genitourin Cancer 2018 Dec 5. Epub 2018 Dec 5.

Kidney Cancer Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX; Division of Hematology and Oncology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX. Electronic address:

Background: Brain metastases (BM) occur frequently in patients with metastatic kidney cancer and are a significant source of morbidity and mortality. Although historically associated with a poor prognosis, survival outcomes for patients in the modern era are incompletely characterized. In particular, outcomes after adjusting for systemic therapy administration and International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk factors are not well-known. Read More

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December 2018

Scalable Manufacturing of Enteric Encapsulation Systems for Site-Specific Oral Insulin Delivery.

Biomacromolecules 2018 Dec 11. Epub 2018 Dec 11.

Oral drug delivery is a more favored mode of administration because of its ease of administration, high patient compliance, and low healthcare costs. However, no oral protein formulations are commercially available currently due to the hostile gastrointestinal (GI) barriers resulting in insignificant oral bioavailability of macromolecular drugs. Herein, we used insulin as a model protein drug, insulin-loaded N-(2-hydroxy)-propyl-3-trimethylammonium chloride modified chitosan (HTCC)/sodium tripolyphosphate (TPP) nanocomplex (NC) as a nanocore was further encapsulated into enteric Eudragit L100-55 material through two-step flash nanocomplexation (FNC) process in a reliable and scalable manner, forming our NC-in-Eudragit composite particles (NE). Read More

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December 2018
1 Read

Enhanced stent visualization systems during PCI: A case series and review of literature.

J Cardiol Cases 2015 Jul 29;12(1):1-5. Epub 2015 Mar 29.

Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Cona FE, Italy.

Enhanced stent visualization systems increase the amount and quality of information during percutaneous coronary interventions. When compared to imaging techniques such as intravascular ultrasound and optical coherence tomography, enhanced stent visualization systems are easy-to-use, as well as time and cost saving. They are useful during stent implantation, overlap, assessment of integrity, and expansion. Read More

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When face-tracking meets social networks: a story of politics in news videos.

Appl Netw Sci 2016 1;1(1). Epub 2016 Jun 1.

1National Institute of Informatics, 2-1-2 Hitotsubashi, Chiyoda-ku, Tokyo, 101-8430 Japan.

In the age of data processing, news videos are rich mines of information. After all, the news are essentially created to convey information to the public. But can we go beyond what is directly presented to us and see a wider picture? Many works already focus on what we can discover and understand from the analysis of years of news broadcasting. Read More

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The two-fluid dynamics and energetics of the asymmetric magnetic reconnection in laboratory and space plasmas.

Nat Commun 2018 12 6;9(1):5223. Epub 2018 Dec 6.

University of New Hampshire, Durham, NH, 03824, USA.

Magnetic reconnection is a fundamental process in magnetized plasma where magnetic energy is converted to plasma energy. Despite huge differences in the physical size of the reconnection layer, remarkably similar characteristics are observed in both laboratory and magnetosphere plasmas. Here we present the comparative study of the dynamics and physical mechanisms governing the energy conversion in the laboratory and space plasma in the context of two-fluid physics, aided by numerical simulations. Read More

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December 2018

Novel strains in malaria vectors from Sub-Saharan Africa.

Wellcome Open Res 2018 27;3:113. Epub 2018 Nov 27.

Department of Disease Control, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.

, a common insect endosymbiotic bacterium that can influence pathogen transmission and manipulate host reproduction, has historically been considered absent from the  genera, but has recently been found in  s.l. populations in West Africa. Read More

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November 2018
2 Reads

[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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December 2018
2 Reads

Root colonization by Pseudomonas chlororaphis primes tomato (Lycopersicum esculentum) plants for enhanced tolerance to water stress.

J Plant Physiol 2018 Nov 16;232:82-93. Epub 2018 Nov 16.

National Research Council of Italy - Institute for Sustainable Plant Protection (CNR-IPSP), Viale P.A. Mattioli 25, 10125 Torino, Italy.

Previous research demonstrated that Pseudomonas chlororaphis subsp. aureofaciens strain M71, a plant growth promoting bacterium (PGPB), exerts beneficial effects on plant metabolism and primes tolerance mechanisms against biotic stresses in tomatoes. We designed an experiment to assess whether root colonization with P. Read More

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November 2018

Elevated arsenic exposure and efficient arsenic metabolism in indigenous women around Lake Poopó, Bolivia.

Sci Total Environ 2018 Dec 2;657:179-186. Epub 2018 Dec 2.

Hydrosciences Montpellier, Institut de Recherche pour le Développement, CNRS, University of Montpellier, France.

Elevated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around Lake Poopó, Bolivia. This study aimed to assess human exposure to arsenic in villages around Lake Poopó, and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other Andean areas. We recruited 201 women from 10 villages around Lake Poopó. Read More

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December 2018

Molecular and cellular basis of depigmentation in vitiligo patients.

Exp Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.

Vitiligo is a chronic skin disease characterized by the appearance of zones of depigmentation. It is mostly described as an autoimmune disease in which the immune system destroys the melanocytes. Consistent with this origin, genetic studies have implicated genes encoding proteins mediating the immune response targeting melanocytes in the etiology of this disease, together with proteins specific to these cells. Read More

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December 2018
1 Read

Spawning energetics and otolith microchemistry provide insights into the stock structure of bonga shad Ethmalosa fimbriata.

J Fish Biol 2018 Dec 11. Epub 2018 Dec 11.

Leibniz Centre for Tropical Marine Research (ZMT), Bremen, Germany.

The gross energy content of spawning batches and the microchemistry of sagittal otoliths in individual female bonga shad Ethmalosa fimbriata were compared between contrasting sampling sites at the Senegalese south coast and inside the hypersaline Sine Saloum Estuary. Results show that females spawning in the estuary's middle reaches invested almost three times more energy into reproduction (115 ± 65 J g body mass) than their neritic counterparts (39 ± 34 J g body mass). Also, female otolith levels of Ba:Ca, Sr:Ca and Zn:Ca either differed significantly between study sites or could be linked to heterogeneous environmental variables. Read More

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December 2018

Groundwater under threat from diffuse contaminants: improving on-site sanitation, agriculture and water supply practices.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Rural Water Supply Network, Skat Foundation, St. Gallen, Switzerland.

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December 2018

Pain in patients with newly diagnosed or relapsed acute leukemia.

Support Care Cancer 2018 Dec 8. Epub 2018 Dec 8.

Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, 610 University Ave., 16-712, Toronto, Ontario, M5G 2M9, Canada.

Purpose: Acute leukemia (AL) is associated with substantial morbidity and mortality. We assessed the prevalence and correlates of pain in patients with newly diagnosed or relapsed AL.

Methods: Patients with newly diagnosed or relapsed AL admitted to a comprehensive cancer center completed the Memorial Symptom Assessment Scale (MSAS), which assesses prevalence, severity, and distress associated with pain and other symptoms. Read More

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December 2018

Mapping terrestrial oil spill impact using machine learning random forest and Landsat 8 OLI imagery: a case site within the Niger Delta region of Nigeria.

Environ Sci Pollut Res Int 2018 Dec 7. Epub 2018 Dec 7.

Department of Geography, University of Leicester, Leicester, United Kingdom.

Terrestrial oil pollution is one of the major causes of ecological damage within the Niger Delta region of Nigeria and has caused a considerable loss of mangroves and arable croplands since the discovery of crude oil in 1956. The exact extent of landcover loss due to oil pollution remains uncertain due to the variability in factors such as volume and size of the oil spills, the age of oil, and its effects on the different vegetation types. Here, the feasibility of identifying oil-impacted land in the Niger Delta region of Nigeria with a machine learning random forest classifier using Landsat 8 (OLI spectral bands) and Vegetation Health Indices is explored. Read More

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December 2018

Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions.

Eur Radiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75022, USA.

Peripheral nerve sheath tumors (PNSTs) account for ~ 5% of soft tissue neoplasms and are responsible for a wide spectrum of morbidities ranging from localized neuropathy to fulminant metastatic spread and death. MR imaging represents the gold standard for identification of these neoplasms, however, current anatomic MR imaging markers do not reliably detect or differentiate benign and malignant lesions, and therefore, biopsy or excision is required for definitive diagnosis. Diffusion-weighted MR imaging (DWI) serves as a useful tool in the evaluation and management of PNSTs by providing functional information regarding the degree of diffusion, while diffusion tensor imaging (DTI) aids in determining the directional information of predominant diffusion and has been shown to be particularly useful for pre-operative planning of these tumors by delineating healthy and pathologic fascicles. Read More

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December 2018

Alterations on Cellular Redox States upon Infection and Implications for Host Cell Homeostasis.

Exp Suppl 2018 ;109:197-220

Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.

The cofactors nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP, are crucial molecules present in all living cells. The delicate balance between the oxidized and reduced forms of these molecules is tightly regulated by intracellular metabolism assuring the maintenance of homeostatic conditions, which are essential for cell survival and proliferation. A recent cluster of data has highlighted the importance of the intracellular NAD/NADH and NADP/NADPH ratios during host-pathogen interactions, as fluctuations in the levels of these cofactors and in precursors' bioavailability may condition host response and, therefore, pathogen persistence or elimination. Read More

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January 2018

International external quality assurance of JAK2 V617F quantification.

Ann Hematol 2018 Dec 8. Epub 2018 Dec 8.

Department of Hematology, Zealand University Hospital, Roskilde, Denmark.

External quality assurance (EQA) programs are vital to ensure high quality and standardized results in molecular diagnostics. It is important that EQA for quantitative analysis takes into account the variation in methodology. Results cannot be expected to be more accurate than limits of the technology used, and it is essential to recognize factors causing substantial outlier results. Read More

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December 2018
2.634 Impact Factor

Save the meniscus again!

Knee Surg Sports Traumatol Arthrosc 2018 Dec 10. Epub 2018 Dec 10.

Orthopaedic Department, Centre Hospitalier de Versailles, 177, rue de Versailles, 78157, Le Chesnay, France.

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December 2018

Increased risk of malaria during the first year of life in small-birth-weight-for-gestational age infants: a longitudinal study in Benin.

J Infect Dis 2018 Dec 7. Epub 2018 Dec 7.

MERIT, IRD, Université Paris 5, Sorbonne Paris Cité, Paris, France.

Background: According to the DOHaD paradigm, the foetal period is one of the most vulnerable periods that may have profound effects on health later in life. Few studies have assessed the effect of small-birth-weight-for-gestational age (SGA), a proxy for foetal growth impairment, on the risk of malaria during infancy in Africa.

Methods: We used data from a cohort of 398 mother-child pairs, followed from early pregnancy to age one in Benin. Read More

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December 2018

Abatacept initiation in rheumatoid arthritis and the risk of cancer: a population-based comparative cohort study.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada.

Objective: To assess whether abatacept as initial biological DMARD (bDMARD) in the treatment of RA, when compared with other bDMARDs, is associated with an increased risk of cancer overall and by specific cancer sites (breast, lung, lymphoma, melanoma and non-melanoma skin cancer).

Methods: We performed a population-based cohort study among patients newly treated with bDMARDs within the US-based Truven MarketScan population and Supplemental US Medicare from 2007 to 2014. Cox proportional hazards models were used to estimate hazard ratios and 95% CIs of any cancer (and specific cancers) associated with initiation of abatacept, compared with initiation of other bDMARDs, adjusted for age and deciles of the propensity score. Read More

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December 2018

Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies.

Am J Clin Nutr 2018 Sep;108(3):453-475

Departments of Complex Genetics.

Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Read More

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September 2018

Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA.

J Infect Dis 2019 Jan;219(1):110-120

School of Public Health, University of Alberta, Edmonton, Canada.

Background: In pregnancy, Plasmodium falciparum parasites express the surface antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A (CSA) in the placenta. VAR2CSA antibodies are generally acquired during infection in pregnancy and are associated with protection from placental malaria. We observed previously that men and children in Colombia also had antibodies to VAR2CSA, but the origin of these antibodies was unknown. Read More

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January 2019

Effectiveness and Safety of Reference Infliximab and Biosimilar in Crohn Disease: A French Equivalence Study.

Ann Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Caisse Nationale de l'Assurance Maladie, Paris, and Hôpital Bicêtre, Le Kremlin-Bicêtre, France (A.M., J.C.).

Background: CT-P13 is a biosimilar of the reference product (RP) infliximab, with demonstrated efficacy and safety for some inflammatory arthritides. It was approved for the treatment of Crohn disease (CD) on that basis, without specific studies examining its effects in CD.

Objective: To compare the effectiveness and safety of CT-P13 and RP in infliximab-naive patients with CD. Read More

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December 2018

Dietary methionine restriction reduces hepatic steatosis and oxidative stress in high-fat-fed mice by promoting HS production.

Food Funct 2018 Dec 10. Epub 2018 Dec 10.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. and Center for Food Nutrition and Functional Food Engineering, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.

Methionine is an essential amino acid that plays important roles in mammalian metabolism. Interestingly, previous studies have consistently shown that a methionine-restricted diet (MRD) reduces hepatic lipid levels, reactive oxygen species production, and oxidative stress damage. However, the mechanisms responsible for these beneficial effects are unknown. Read More

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December 2018

Insight into the factors influencing NMR parameters in crystalline materials from the KF-YF binary system.

Dalton Trans 2018 Dec 11. Epub 2018 Dec 11.

Institut des Molécules et Matériaux du Mans (IMMM), UMR 6283 CNRS, Le Mans Université, Le Mans, Cedex 9, France.

Solid state NMR signals are very sensitive to the local environment of the observed nucleus; however, their interpretation is not straightforward. On the other hand, first-principles DFT calculations of NMR parameters can now be applied to periodic compounds to predict NMR parameters. Thus, ab initio calculations can help to interpret the NMR spectra exhibited by complex materials, to assign NMR lines to structural environments, and even to enlighten the environmental factors influencing the NMR parameters for a given nucleus. Read More

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December 2018

Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents.

Cell Mol Gastroenterol Hepatol 2019 20;7(1):185-196. Epub 2018 Sep 20.

Université Lille, INSERM, CHR Lille, Lille Inflammation Research International Center, U995, Lille, France.

Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known. Aluminum is commonly present in food, notably by its use as food additive. Read More

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September 2018

From "under" to "over" social cognition in schizophrenia: Is there distinct profiles of impairments according to negative and positive symptoms?

Schizophr Res Cogn 2019 Mar 8;15:21-29. Epub 2018 Nov 8.

University Department of Rehabilitation (SUR-CL3R), Le Vinatier hospital, 4 rue Jean Sarrazin, 69008 Lyon, France.

Interactions between social cognition and symptoms of schizophrenia have been investigated, but mostly component by component. Here we tested the assumption that two categories of deficits exist depending on clinical profiles, one corresponding to a defect in social cognition - "under-social cognition" - and one corresponding to excessive attributions leading to social cognitive impairments - "over-social cognition". To conduct the investigation, we performed a Hierarchical Clustering Analysis using positive and negative symptoms in seventy patients with schizophrenia and we compared the clusters obtained to a group of healthy controls on social cognitive measures. Read More

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NON-CONTACT ANTERIOR CRUCIATE LIGAMENT AND LOWER EXTREMITY INJURY RISK PREDICTION USING FUNCTIONAL MOVEMENT SCREEN AND KNEE ABDUCTION MOMENT: AN EPIDEMIOLOGICAL OBSERVATION OF FEMALE INTERCOLLEGIATE ATHLETES.

Int J Sports Phys Ther 2018 Dec;13(6):973-984

University of Idaho, Moscow, ID, USA.

Background: Modifiable risk factors associated with non-contact anterior cruciate ligament (ACL) injuries are highly debated, yet the incidence rate of ACL injury continues to increase. Measures of movement quality may be an effective method for identifying individuals who are at a high risk of injury.

Purpose: The purpose of this study was to investigate whether a movement screen and/or a drop-jump landing (DJL) task identifies female individuals at a higher risk for sustaining non-contact lower extremity (LE) injuries, particularly ACL injuries. Read More

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December 2018

Anaplastic Pleomorphic Xanthoastrocytoma Presenting with Musical Hallucination.

Case Rep Neurol Med 2018 11;2018:6428492. Epub 2018 Nov 11.

Reading Hospital, Tower Health System, Reading, PA, USA.

Musical hallucinations are a relatively rare form of auditory hallucination characterized by hearing of music in the absence of any external stimuli. This phenomenon has been linked to both psychiatric and structural lesions. We present the case of a previously healthy young male whose presentation with musical hallucinations led to the diagnosis of a rare tumour, anaplastic pleomorphic xanthoastrocytoma. Read More

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November 2018

Travel to Asia is a strong predictor for carriage of cephalosporin resistant and but does not explain everything; prevalence study at a Norwegian hospital 2014-2016.

Antimicrob Resist Infect Control 2018 29;7:146. Epub 2018 Nov 29.

1Department of Antibiotic Resistance and Infection Prevention, Norwegian Institute of Public Health, PO Box 222 Skøyen, 0213 Oslo, NO Norway.

Background: We aimed to estimate the prevalence of faecal carriage of extended-spectrum cephalosporin (ESC) resistant and (ESCr-EK) and vancomycin resistant enterococci (VRE) in patients upon hospital admission and identify factors associated with carriage to better target interventions and to guide empirical antibiotic treatment.

Methods: Between October 2014 and December 2016, we recruited patients admitted to a Norwegian university hospital. A rectal swab and questionnaire covering possible risk factors for colonisation were collected upon admission. Read More

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November 2018

Authors' Response to the Comments on "How Do Our Patients Respond to the Concept of Psychiatric Advance Directives? An Exploratory Study from India".

Indian J Psychol Med 2018 Nov-Dec;40(6):588-589

Department of Psychiatry, K.LE Academy of Higher Education's, J.N Medical College, Belagavi, Karnataka, India.

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December 2018