100 results match your criteria Laugier-Hunziker Syndrome


Laugier-Hunziker syndrome: a case and dermoscopic features.

Dermatol Online J 2021 Dec 15;27(12). Epub 2021 Dec 15.

Outpatient Department of Dermatology, Local Health Centre Taranto, Taranto, Italy,.

Laugier-Hunziker syndrome (LHS) is a sporadic, acquired, and infrequent condition characterized by the onset of brown macules on the lips, the oral mucosa, and the acral glabrous skin (mainly fingers and toes) in middle-aged patients. In several cases melanonychia of fingernails and toenails coexists. No other systemic involvement is observed. Read More

View Article and Full-Text PDF
December 2021

Keratosis pilaris atrophicans faciei: An observational, descriptive, retrospective clinical study.

Exp Ther Med 2021 Nov 20;22(5):1331. Epub 2021 Sep 20.

Department of Dermatology, Dermatology Clinic, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.

Keratosis pilaris atrophicans faciei (KPAF) is a hereditary follicular disorder, an atrophicans subtype of keratosis pilaris (KP) with a highly elusive diagnosis. Clinically, it presents with follicular, horny papules surrounded by an erythematous halo of the cheeks, forehead, chin and eyebrows, and it is followed by a gradual hair loss on the lateral margins of the eyebrows. The onset is as early as a few months after birth, but it is mainly diagnosed in children and adolescents and it can persist through adulthood. Read More

View Article and Full-Text PDF
November 2021

Progressive hyperpigmentation over hands and feet in a young male.

Pediatr Dermatol 2021 07;38(4):e28-e29

Department of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences, Jodhpur, India.

View Article and Full-Text PDF

[Laugier-Hunziker syndrome : A rare differential diagnosis of mucocutaneous hyperpigmentation].

Hautarzt 2022 Apr 25;73(4):298-302. Epub 2021 Jun 25.

Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Laugier-Hunziker syndrome (LHS) is characterized by lentiginous hyperpigmentation of the oral mucosa and lips. In addition, longitudinal melanonychia and palmoplantar hyperpigmented lesions may occur. LHS is a clinical diagnosis of exclusion. Read More

View Article and Full-Text PDF

Clinical and histopathological differential diagnosis of Laugier-Hunziker syndrome: An extremely rare case with unusual extensive oral hyperpigmentation.

Clin Case Rep 2021 Jan 16;9(1):309-313. Epub 2020 Nov 16.

Retired Oral Medicine Consultant Edinburgh UK.

Laugier-Hunziker syndrome is a rare and benign disorder characterized by hyperpigmentation of the lips and buccal mucosae with associated longitudinal melanonychia of nails. Clinical correlation is needed to rule out other pigmentary disorders. Read More

View Article and Full-Text PDF
January 2021

Oral pigmented lesions in syndromic individuals: A systematic review.

Oral Dis 2022 Apr 16;28(3):531-540. Epub 2021 Jan 16.

Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Brazil.

Objective: To systematically integrate the available data published in the literature on oral pigmented lesions (OPL) associated with syndromes, summarizing the clinical and demographic features of the individuals.

Materials And Methods: An electronic search was undertaken in six databases. Eligibility criteria were articles in English, Spanish, and Portuguese describing case reports or case series of OPL associated with syndromes. Read More

View Article and Full-Text PDF

Possible transmission of Laugier-Hunziker syndrome by allogeneic peripheral blood stem cell transplantation.

Clin Exp Dermatol 2021 Mar 20;46(2):400-402. Epub 2020 Nov 20.

Department of Dermatology, Portsmouth Hospitals NHS Trust, Portsmouth, Hampshire, UK.

View Article and Full-Text PDF

Laugier-Hunziker syndrome: a case report of the pediatric patient and review of the literature.

Int J Dermatol 2020 Dec 29;59(12):1513-1519. Epub 2020 Oct 29.

Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Poland.

Laugier-Hunziker syndrome (LHS) is a rare, idiopathic pigmentary disorder especially affecting the lips and oral mucosa. At present, no more than 200 cases of patients diagnosed with LHS syndrome have been described worldwide. To date, three patients under the age of 20 have been described, including the youngest patient who is a 12-year-old child. Read More

View Article and Full-Text PDF
December 2020

Laugier-Hunziker Syndrome in an 8-Year-Old Boy with Scleral Melanocytosis, Lingual Pigmentation, Labial Pigmentation, and Melanonychia Striata.

Case Rep Pediatr 2020 17;2020:8267805. Epub 2020 Mar 17.

Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia V5Z 1K1, Canada.

Laugier-Hunziker syndrome is a rare, acquired disorder characterized by mucocutaneous hyperpigmentation and melanonychia striata with no underlying systemic abnormalities. We report an 8-year-old boy with Laugier-Hunziker syndrome who presented with melanonychia striata affecting all the fingernails and toenails, macular pigmentation on the tongue and the lower lip, and scleral melanocytosis. Melanonychia striata rarely affect all the twenty nails, and scleral melanocytosis has rarely been reported in association with Laugier-Hunziker syndrome. Read More

View Article and Full-Text PDF

Black Maculae between the Toes: A Rare Form of Laugier-Hunziker Syndrome?

Indian J Dermatol 2020 Jan-Feb;65(1):69-70

Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. E-mail:

View Article and Full-Text PDF
February 2020

A case of recurrent pigmented macules in Laugier-Hunziker syndrome treated using a Q-switched Nd-YAG laser.

J Cosmet Laser Ther 2019 16;21(7-8):395-397. Epub 2019 Oct 16.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Republic of Korea.

Laugier-hunziker syndrome (LHS) is a sporadic and acquired melanotic pigmentation of lips and oral mucosa which is not associated with gastrointestinal hamartomas in contrast to Peutz-Jeghers syndrome. Treatment using Q-switched neodymium: yttrium-aluminum-garnet (QS-ND:YAG) laser, Q-switched alexandrite laser and, cryotherapy have been reported. However, to the best of our knowledge, there is no report regarding long-term follow-up for recurrence. Read More

View Article and Full-Text PDF

Laugier-Hunziker syndrome: complete clearance of mucosal lentigines with a single session of Q-Switched Nd:YAG laser.

Authors:
Vivek Nair

J Cosmet Laser Ther 2019 2;21(6):343-345. Epub 2019 Sep 2.

Dr Nair's Skin Clinic & Hair Transplant Centre , Gurgaon , India.

: Laugier-Hunziker (LH) syndrome is a rare condition in which melanocyte overactivity produces lentiginous lesions of the lips and buccal mucosa. : Given the paucity of reports on therapeutic options in LH syndrome, this case is herein reported to show the response to treatment with the Q-Switched Nd:YAG laser in a 32-year-old man with LH Syndrome. : The Q-Switched Nd:YAG laser was used to treat the lentiginous lesions on the mucosal surface of the lower lips using a single pass at 532 nm. Read More

View Article and Full-Text PDF

Levodopa-induced skin disorders in patients with Parkinson disease: a systematic literature review approach.

Acta Neurol Belg 2019 Sep 23;119(3):325-336. Epub 2019 Jul 23.

1st Department of Neurology and Movement Disorders, National and Kapodistrian University of Athens, Medical School, Aeginition Hospital, 72-74 Vasilissis Sofias Avenue, 11528, Athens, Greece.

The use of levodopa for treatment of Parkinson's disease is a well-established clinical practice. Data about the true incidence and severity of cutaneous complications associated with the use of levodopa are largely lacking. Aim of this review was to evaluate the quality of evidence referring to the skin disorders caused by levodopa treatment for Parkinson's disease. Read More

View Article and Full-Text PDF
September 2019

Melanonychia striata: clarifying behind the Black Curtain. A review on clinical evaluation and management of the 21st century.

Int J Dermatol 2019 Nov 21;58(11):1239-1245. Epub 2019 Apr 21.

Departments of Pediatrics, Laboratory Medicine, and Pathology, The University of Alberta, Edmonton, Alberta, Canada.

Melanonychia striata is characterized by a tan, brown, or black longitudinal streak within the nail plate that runs from the proximal nail fold to the distal part of the nail plate. Melanonychia striata is due to increased activity of melanocytes or melanocytic hyperplasia in the nail matrix with subsequently increased melanin deposition in the nail plate. The most common cause of melanonychia striata associated with melanocytic activation is ethnic melanonychia which occurs in dark-skinned individuals. Read More

View Article and Full-Text PDF
November 2019

Laugier-Hunziker syndrome in a patient with rheumatoid arthritis.

Reumatologia 2019 28;57(1):63-65. Epub 2019 Feb 28.

Department of Dermatology and Venereology, Akdeniz University School of Medicine, Antalya, Turkey.

Laugier-Hunziker syndrome is a rare benign idiopathic condition characterized by acquired macular pigmentation of the lips and buccal mucosa, often accompanied by melanonychia. Although the etiopathogenesis is not fully known, tyrosine is thought to be responsible for the pathogenesis of enzyme hyperactivity in melanin biosynthesis. We present the case of a 66-year-old woman diagnosed with Laugier-Hunziker syndrome and rheumatoid arthritis. Read More

View Article and Full-Text PDF
February 2019

Two cases of Laugier-Hunziker syndrome with thrombocytopenia.

Eur J Dermatol 2018 Dec;28(6):830-831

Department of Dermatology, Seoul National University Bundang hospital, 82 Gumi-ro 173 Beon-Gil, Bundang-gu, Seongnam-si, 463-707, Gyeonggi-do, Korea.

View Article and Full-Text PDF
December 2018

Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome.

World J Clin Cases 2018 Sep;6(10):322-334

Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China.

Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome (LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. Read More

View Article and Full-Text PDF
September 2018

Laugier-Hunziker syndrome in endocrine clinical practice.

Endocrinol Diabetes Metab Case Rep 2018 26;2018. Epub 2018 Jul 26.

Departments of Endocrinology, Diabetes and Metabolic Diseases.

Laugier-Hunziker syndrome (LHS) is a rare, benign and acquired disorder characterized by hyperpigmentation of the oral cavity and lips along with longitudinal melanonychia. No underlying systemic abnormalities or malignant predisposition is associated with it. In everyday clinical practice, an endocrinologist encounters certain endocrine conditions (e. Read More

View Article and Full-Text PDF

Case Report: Dermoscopic features of oral lichen planus - the evolution of mucoscopy.

F1000Res 2018 6;7:284. Epub 2018 Mar 6.

Department of Dermatology, College of Medicine, King Faisal University, Hofuf, Saudi Arabia.

Dermoscopy, a non-invasive technique for cutaneous diagnosis is being increasingly studied in various disorders of the skin, nails and scalp. However, it has been under-utilized for the diagnosis and characterization of mucosal disorders. The dermoscopic characterization of cutaneous lichen planus and its variants has been well documented with Wickham's striae constituting the hallmark of the condition. Read More

View Article and Full-Text PDF

Laugier-Hunziker Syndrome Presenting with Metachronous Melanoacanthomas.

Head Neck Pathol 2019 Jun 15;13(2):257-263. Epub 2018 Feb 15.

Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, The State University of New York, 355 Squire Hall, 3435 Main Street, Buffalo, NY, 14214-3008, USA.

Laugier-Hunziker syndrome (LHS, also termed idiopathic lenticular mucocutaneous hyperpigmentation) is an unusual condition characterized by progressive pigmentation of the mucous membranes. LHS displays a benign course and is not associated with malignancy. Here we present a case of LHS with a 7-year follow-up. Read More

View Article and Full-Text PDF

Laugier-Hunziker syndrome: A case report.

J Stomatol Oral Maxillofac Surg 2018 Apr 12;119(2):158-160. Epub 2017 Dec 12.

Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, 210008 Nanjing, China. Electronic address:

Laugier-Hunziker syndrome (LHS) is a rare, benign, acquired pigmentary condition mainly affecting lips, oral mucosa and acral area, frequently associated with longitudinal melanonychia. Herein, we reported a 45-year-old female case with LHS. The clinical, dermoscopic, histopathologic features of LHS were reviewed and the important differential diagnosis was discussed. Read More

View Article and Full-Text PDF

Laugier-Hunziker syndrome.

Cutis 2017 09;100(3):E17-E19

Department of Dermatology, United States Naval Hospital, Yokosuka, Japan.

View Article and Full-Text PDF
September 2017

Efficacy of surgical laser therapy in the management of oral pigmented lesions: A systematic review.

J Photochem Photobiol B 2017 Aug 15;173:353-359. Epub 2017 Jun 15.

Division of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, United States.

Background: Oral pigmentation, especially in the gingiva poses esthetic problems. Laser therapy has been widely used for cosmetic therapy in dentistry. The aim of the present study was to systematically review the efficacy of surgical laser therapy (SLT) in the management of oral pigmented lesions (OPL). Read More

View Article and Full-Text PDF

Anaemia with Laugier-Hunziker Syndrome: a diagnostic dilemma.

Singapore Med J 2017 05;58(5):281

Department of Otorhinolaryngology-Head and Neck Surgery, John Hopkins School of Medicine, Baltimore, USA.

View Article and Full-Text PDF

Laugier-Hunziker syndrome: a case of asymptomatic mucosal and acral hyperpigmentation.

Dermatol Pract Concept 2017 Apr 30;7(2):27-30. Epub 2017 Apr 30.

Department of Dermatology, University Hospital Zurich, Zurich Switzerland.

Laugier-Hunziker syndrome (LHS) is a rare condition characterized by acquired hyperpigmentation involving the lips, oral mucosa, acral surfaces, nails and perineum. While patients with LHS may manifest pigmentation in all of the aforementioned areas, most present with pigmentation localized to only a few of these anatomical sites. We herein report a patient exhibiting the characteristic pigment distribution pattern associated with LHS. Read More

View Article and Full-Text PDF

Laugier-Hunziker Syndrome in a Young Female.

Indian Dermatol Online J 2017 Mar-Apr;8(2):148-150

Department of Dermatology, Venereology and Leprology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India.

View Article and Full-Text PDF

Lentiginous phenotypes caused by diverse pathogenic genes (SASH1 and PTPN11): clinical and molecular discrimination.

Clin Genet 2016 10 3;90(4):372-7. Epub 2016 Feb 3.

Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Pathogenic mutations in genes (SASH1 and PTPN11) can cause a rare genetic disorder associated with pigmentation defects and the well-known LEOPARD syndrome, respectively. Both conditions presented with lentiginous phenotypes. The aim of this study was to arrive at definite diagnoses of three Chinese boys with clinically suspected lentigines-related syndromes. Read More

View Article and Full-Text PDF
October 2016

[Laugier-Hunziker syndrome in a patient with Sjögren’s syndrome: Report of one case].

Rev Med Chil 2016 May;144(5):671-4

Laugier-Hunziker syndrome is a rare benign idiopathic condition characterized by acquired macular pigmentation of lips and buccal mucosa, often accompanied with melanonychia. The main concern with this condition is to rule out other differential diagnosis with systemic repercussions and similar hyperpigmentation patterns, such as Peutz-Jeghers syndrome, adrenal insufficiency and melanoma. We report a 58-year-old female with a 20-year history of Sjögren’s syndrome, presenting with melanonychia and hyperpigmentation in the buccal mucosa. Read More

View Article and Full-Text PDF

Laugier-Hunziker Syndrome Revisited.

Indian J Dermatol 2016 May-Jun;61(3):338-9

Department of Dermatology, Katihar Medical College, Katihar, Bihar, India.

View Article and Full-Text PDF