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Cell Mol Life Sci 2021 Jun 3. Epub 2021 Jun 3.

Nerve Regeneration Group, IBMC- Instituto de Biologia Molecular e Celular and i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135, Porto, Portugal.

The identification of the membrane periodic skeleton (MPS), composed of a periodic lattice of actin rings interconnected by spectrin tetramers, was enabled by the development of super-resolution microscopy, and brought a new exciting perspective to our view of neuronal biology. This exquisite cytoskeleton arrangement plays an important role on mechanisms regulating neuronal (dys)function. The MPS was initially thought to provide mainly for axonal mechanical stability. Read More

BMJ Case Rep 2021 Jun 2;14(6). Epub 2021 Jun 2.

Ophthalmology, Government Medical College and Hospital, Chandigarh, India.

A 7-year-old boy with Marfanoid habitus presented with sudden and painless decrease in the vision of the right eye. Ocular examination revealed rhegmatogenous retinal detachment with 360° giant retinal tear in the right eye and small peripheral retinal breaks with lattice degeneration in the left eye. The patient underwent a 23-gauge pars plana vitrectomy with scleral buckling in the right eye and laser around the breaks in the left eye. Read More

Case Rep Ophthalmol 2021 Jan-Apr;12(1):248-253. Epub 2021 Apr 12.

Department of Surgery, University of Illinois College of Medicine, Peoria, Illinois, USA.

We present 2 cases of iatrogenic retinal penetration from intravitreal (IVT) injections in a retrospective noncomparative case series of 2 patients. The first patient, an 81-year-old Caucasian male, developed dense vitreous hemorrhage soon after receiving an IVT bevacizumab injection for macular edema from central retinal vein occlusion. A 25-g vitrectomy 1 week later showed a retinal hole surrounded by fresh hemorrhages in the same quadrant as the IVT injection. Read More

Case Rep Ophthalmol 2021 Jan-Apr;12(1):219-226. Epub 2021 Apr 12.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.

Purpose: The purpose of this report was to present our findings in 4 cases of rhegmatogenous retinal detachment (RRD) that recurred 10, 11, 12, and 17 years after a reattachment surgery by pars plana vitrectomy (PPV).

Methods: Four cases of a recurrent RRD had undergone scleral buckling surgery and vitrectomy.

Patients: The recurrence of the RRD was observed 10-17 years after the successful attachment by PPV. Read More

Nanomaterials (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Faculty of Physics, Adam Mickiewicz University in Poznań, ulica Uniwersytetu Poznańskiego 2, PL-61614 Poznań, Poland.

The adsorbed atoms exhibit tendency to occupy a triangular lattice formed by periodic potential of the underlying crystal surface. Such a lattice is formed by, e.g. Read More

BMC Ophthalmol 2021 May 2;21(1):195. Epub 2021 May 2.

Department of Ophthalmology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu City, Chiba, 279-0021, Japan.

Background: Sympathetic ophthalmia (SO) is a bilateral diffuse uveitis that can arise after ocular trauma or ocular surgery in the inciting eye. Pars plana vitrectomy (PPV) is one of the risk factors for SO. Several reports have described SO developing after 23- and 25-G PPV, but none have described SO occurring after 27-G PPV. Read More

J Comp Neurol 2021 Aug 6;529(11):3013-3031. Epub 2021 Apr 6.

Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo, Japan.

Visual opsins are proteins expressed by retinal photoreceptors that capture light to begin the process of phototransduction. In vertebrates, the two types of photoreceptors (rods and cones) express one or multiple opsins and are distributed in variable patterns across the retina. Some cones form opsin retinal gradients, as in the mouse, whereas others form more demarcated opsin domains, as in the lattice-like mosaic retinas of teleost fishes. Read More

Eur J Hum Genet 2021 May 25;29(5):881-886. Epub 2021 Feb 25.

Eye Genetics Research Unit, The Children's Hospital at Westmead, Save Sight Institute, Children's Medical Research Institute, University of Sydney, Sydney, NSW, Australia.

The COL9A3 gene encodes one of the three alpha chains of Type IX collagen, with heterozygous variants reported to cause multiple epiphyseal dysplasia, and suggested as contributory in some cases of sensorineural hearing loss. Patients with homozygous variants have midface hypoplasia, myopia, sensorineural hearing loss, epiphyseal changes and carry a diagnosis of Stickler syndrome. Variants in COL9A3 have not previously been reported to cause vitreoretinal degeneration and/or retinal detachments. Read More

Vestn Oftalmol 2021 ;137(1):46-52

Tradomed Invest JSC, Moscow, Russia.

Purpose: To evaluate the first outcomes of non-contact navigated laser retinopexy for peripheral tears and rhegmatogenous degenerations of the retina.

Material And Methods: This prospective single-center interventional pilot study included 58 patients (68 eyes), among which 19 males and 39 females aged 47.5±16. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Feb 4. Epub 2021 Feb 4.

Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1# Shuai Fu Yuan, Dongcheng District, Beijing, 100730, China.

Purpose: To investigate the detection of lattice degeneration, retinal breaks, and retinal detachment in tessellated eyes using ultra-wide-field fundus imaging system (Optos) with convolutional neural network technology.

Methods: This study included 1500 Optos color images for tessellated fundus confirmation and peripheral retinal lesion (lattice degeneration, retinal breaks, and retinal detachment) assessment. Three retinal specialists evaluated all images and proposed the reference standard when an agreement was achieved. Read More

Cornea 2021 Mar;40(3):370-372

Fundació de Recerca de l'Institut de Microcirurgia Ocular, Barcelona, Spain.

Purpose: This study aims to clinically and genetically report a case of coexisting Meesmann corneal dystrophy (MECD) and pseudo-unilateral lattice corneal dystrophy (LCD).

Methods: Clinical characterization was supported by a complete ophthalmological evaluation, including visual acuity measurement and slit-lamp examination. Molecular diagnosis was performed by whole-exome sequencing analyzing the gelsolin, keratin K3 (KRT3), keratin K12, and transforming growth factor-beta-induced genes. Read More

Eur J Ophthalmol 2020 Dec 18:1120672120978884. Epub 2020 Dec 18.

University Hospital Coventry Warwickshire, Coventry, UK.

Introduction: Rhegmatogenous retinal detachment (RRD) is commonly managed by pars plana vitrectomy (PPV). Gas tamponade has significant clinical and quality of life factors that affect the patient. Using shorter acting air tamponade, intuitively leads to surgical concern for higher rate of primary detachment. Read More

PLoS One 2020 10;15(12):e0243766. Epub 2020 Dec 10.

Section of Vitreoretinal Disease and Surgery, Department of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.

The purpose of this study was to describe the ocular findings, structural ocular complications, and vision impairment in a cohort of Lassa fever survivors in Kenema, Sierra Leone. A retrospective, uncontrolled, cross-sectional study of 31 Lassa fever survivors (62 eyes) who underwent an ophthalmic evaluation in January 2018 at the Kenema Government Hospital in Kenema, Sierra Leone was performed. Data collection included demographic information, ocular/systemic symptoms, visual acuity (VA), and ophthalmic examination findings. Read More

Indian J Ophthalmol 2020 Dec;68(12):3002-3005

Department of Ophthalmology, Government Medical College, Nagpur, Maharashtra, India.

Purpose: The purpose of this study is to establish the safety of clear lens extraction (CLE) for the correction of high myopia in patients unfit for implantable contact lenses (ICLs) and laser in situ keratomileusis in the central Indian population.

Methods: In this retrospective observational study performed at a tertiary care centre, medical records of the patients who had undergone CLE with implantation of intraocular lens (IOL) to treat high myopia were retrieved. Details of the demographic profile, surgical procedure, complications, power, and type of IOLs implanted were recorded. Read More

Int J Mol Sci 2020 Oct 5;21(19). Epub 2020 Oct 5.

Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka 569-8686, Japan.

Lattice degeneration involves thinning of the retina that occurs over time. Here we performed an immunohistological study of tissue sections of human peripheral retinal lattice degeneration to investigate if retinal pigment epithelium (RPE) cells are involved in the pathogenesis of this condition. In two cases of retinal detachment with a large tear that underwent vitreous surgery, retinal lattice degeneration tissue specimens were collected during surgery. Read More

Middle East Afr J Ophthalmol 2020 Apr-Jun;27(2):100-104. Epub 2020 Jul 20.

Department of Ophthalmology, Faculty of Medicine and Health Sciences, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.

Purpose: The aim of this study is to evaluate the short anatomical and visual outcomes of scleral buckling surgery in relation to the pattern of presentation of rhegmatogenous retinal detachment (RRD) in the presence of different situations and risk factors.

Methods: A total of 206 eyes of 203 patients who underwent scleral buckling surgery for RRD were evaluated in this retrospective study. Information retrieved included patient demographics, duration of symptoms, and presenting vision, lens status, site of a retinal break, extent of retinal detachment, the involvement of the fellow eye, macular involvement, presence of lattice degeneration, and associated refractive errors. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Feb 12;259(2):301-306. Epub 2020 Aug 12.

University of Pittsburgh, UPMC Eye Center, 203 Lothrop Street, Pittsburgh, PA, 15213, USA.

Aim: To study the diagnostic potential of retro-mode scanning laser ophthalmoscopy (RM-SLO) for evaluation of peripheral retinal lesions.

Methods: Based on the results of indirect ophthalmoscopy, in this study, we included asymptomatic subjects with lattice retinal degeneration, retinal break, or subclinical retinal detachment and subjects without any peripheral retinal lesions. All participants' fundus periphery was examined with RM-SLO over 360° for the presence of peripheral retinal lesions in a masked fashion. Read More

Am J Ophthalmol Case Rep 2020 Sep 9;19:100826. Epub 2020 Jul 9.

Department of Ophthalmology, University of Colorado School of Medicine, 1675 Aurora Ct, F731, Aurora, CO, 80045, United States.

Purpose: Steroid-induced ocular hypertension (OHTN) after penetrating keratoplasty (PKP) may cause irreversible damage to the optic nerve and graft failure. The purpose of this study is to report the first case of a post PKP patient with poorly controlled IOP, successfully treated with Kahook Dual Blade (KDB) goniotomy in both eyes.

Observations: The patient was a 62-year old male with prior PKP in both eyes for lattice corneal degeneration. Read More

JAMA Ophthalmol 2020 08;138(8):826-833

Newcastle Eye Centre, Royal Victoria Infirmary, Newcastle upon Tyne, England.

Importance: Although rhegmatogenous retinal detachment (RRD) repair techniques have high anatomical reattachment rates, there may be differences in various aspects of postoperative vision-related quality of life (VRQoL).

Objective: To explore the differences in various aspects of VRQoL between pneumatic retinopexy (PnR) and pars plana vitrectomy (PPV) following RRD repair.

Design, Setting, And Participants: Post hoc exploratory analysis of the the Pneumatic Retinopexy vs Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes randomized clinical trial conducted between August 2012 and May 2017 at St Michael's Hospital, Toronto, Ontario, Canada. Read More

Mol Genet Genomic Med 2020 08 1;8(8):e1311. Epub 2020 Jun 1.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.

Background: Stickler syndrome is a collagen disorder that can affect multiple organ systems. It is characterized by ocular abnormalities, hearing loss, midfacial hypoplasia, hypermobility, and joint abnormalities. The phenotypic expression of Stickler syndrome can vary among those affected. Read More

Eye (Lond) 2021 Mar 12;35(3):786-790. Epub 2020 May 12.

Ophthalmology Unit, Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.

Background/objectives: To compare the efficacy of intraoperative localized and 360° laser retinopexy in cases of rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy and air tamponade.

Subjects/methods: In this interventional, prospective, randomized, comparative study, 93 consecutive cases of RRD were enroled. After randomization 48 eyes received circumferential, while 45 underwent localized intraoperative laser retinopexy. Read More

Ophthalmol Retina 2020 08 28;4(8):823-828. Epub 2020 Feb 28.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:

Purpose: To evaluate the visual outcomes and complications associated with noninfectious uveitis in patients presenting with a rhegmatogenous retinal detachment (RRD).

Design: Retrospective cohort study.

Participants: A total of 554 eyes of 523 patients presenting for RRD repair at the Department of Ophthalmology, University of Colorado School of Medicine, between July 2011 and September 2016. Read More

J Ophthalmol 2020 13;2020:5085180. Epub 2020 Feb 13.

Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan.

Purpose: We compared the incidences of iatrogenic retinal breaks and postoperative retinal detachment between eyes that underwent 20-gauge vitrectomy and those that underwent 25-gauge vitrectomy for idiopathic macular hole repair.

Methods: This retrospective nonrandomized consecutive observational case series included 185 eyes of 183 patients (130 eyes of 129 patients and 55 eyes of 54 patients in the 20- and 25-gauge groups, respectively). We assessed the relationship between the incidence of retinal breaks and postoperative retinal detachment and related this to posterior vitreous detachment and lattice degeneration. Read More

Ann Transl Med 2019 Nov;7(22):618

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Background: Lattice degeneration and/or retinal breaks, defined as notable peripheral retinal lesions (NPRLs), are prone to evolving into rhegmatogenous retinal detachment which can cause severe visual loss. However, screening NPRLs is time-consuming and labor-intensive. Therefore, we aimed to develop and evaluate a deep learning (DL) system for automated identifying NPRLs based on ultra-widefield fundus (UWF) images. Read More

Mol Vis 2019 5;25:843-850. Epub 2019 Dec 5.

Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.

Purpose: Lattice degeneration of the retina is a vitreoretinal disorder characterized by a visible fundus lesion that predisposes the patient to retinal detachment. It has been suggested that collagen type II alpha 1 () gene variants may contribute to the development of disorders associated with retinal detachment. Here we investigated whether gene variants were associated with the risk of lattice degeneration of the retina. Read More

Ophthalmology 2020 01 25;127(1):P146-P181. Epub 2019 Sep 25.

Center for Preventative Ophthalmology and Biostatistics, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

JAMA Ophthalmol 2019 12;137(12):1399-1405

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Patient care and clinical practice guidelines should be informed by evidence from reliable systematic reviews. The reliability of systematic reviews related to forthcoming guidelines for retina and vitreous conditions is unknown.

Objectives: To summarize the reliability of systematic reviews on interventions for 7 retina and vitreous conditions, describe characteristics of reliable and unreliable systematic reviews, and examine the primary area in which they appeared to be lacking. Read More

Eur J Pain 2020 02 17;24(2):346-353. Epub 2019 Oct 17.

Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI, USA.

Background: Low back pain (LBP) is a widespread problem and the leading cause of disability worldwide. While the cause of LBP is multifactorial, several studies suggested that inflammatory mediators in damaged subchondral plates of degenerating discs may lead to chemical sensitization and mechanical stimulation, eventually causing pain. The goal of this study was to explore associations between such changes and LBP-related disability using dynamic contrast-enhanced MRI. Read More

Clin Ophthalmol 2019 6;13:1743-1748. Epub 2019 Sep 6.

Department of Ophthalmology, National Organization Kyoto Medical Center, Kyoto, Japan.

Purpose: To assess the updated chandelier illumination-assisted scleral buckle procedures using a 3D visualization system.

Subjects And Methods: We report a single-center, retrospective, consecutive surgical case series of 18 eyes of 16 patients that underwent scleral buckle procedures combining the use of chandelier endoillumination, a noncontact wide-angle viewing system, an anti-drying contact lens, and a recently developed 3D visualization system. The mean age of the patients was 30. Read More

Turk J Ophthalmol 2019 09;49(4):209-212

Mustafa Kemal University Faculty of Medicine, Department of Ophthalmology, Hatay, Turkey

Objectives: To investigate the frequency of retinal tear, retinal hole, and lattice degeneration in peripheral retinal examination of patients with macular hole.

Materials And Methods: The files of patients who underwent pars plana vitrectomy surgery with a diagnosis of macular hole at Eskişehir Osmangazi University Department of Ophthalmology between 2008 and 2018 were retrospectively analyzed. A total of 106 patients with primary macular hole who underwent peripheral retinal examination were included in the study. Read More