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Graefes Arch Clin Exp Ophthalmol 2022 May 27. Epub 2022 May 27.

Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Purpose: To analyze the typical presentation of acute posterior vitreous detachment (PVD), including demographics and prevalence of various treatable findings in the same and fellow eye.

Methods: Retrospective analysis of medical records from 2346 patients with acute PVD. Descriptive statistics were generated on age, sex, contact date, visual acuity, and slit lamp, and fundoscopy findings. Read More

Br J Ophthalmol 2022 May 26. Epub 2022 May 26.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada

Background/aim: To assess the utility of single-capture ultra-widefield confocal scanning laser ophthalmoscope with integrated swept-source optical coherence tomography (UWF-SS-OCT) in the management of rhegmatogenous retinal detachment (RRD) and associated peripheral pathology.

Methods: 138 eyes of 101 consecutive patients with RRD and/or associated peripheral pathology at a vitreoretinal practice in Toronto, Canada between December 2020 and February 2021 that had UWF-SS-OCT with interpretable scans were included. A 200 degree fundus photograph was used to navigate a built-in 100 kHz UWF-SS-OCT to image pathology with a high-density 23 mm line scan and/or volume scan. Read More

Vestn Oftalmol 2022 ;138(2):23-30

Saint Petersburg branch of S.N. Fedorov National Medical Research Center «MNTK «Eye Microsurgery», St. Petersburg, Russia.

Focal dome-shaped prominence of the macular profile due to thickening of the scleral layers leads to the development of sclerogenic macular degeneration (SMD), which causes a decrease in vision when it evolves into complicated forms.

Purpose: To evaluate the effectiveness of subthreshold micropulse laser (SML) coagulation in patients with SMD complicated by detachment of neuroepithelium.

Material And Methods: The study included 14 patients (13 women and 1 man), aged 28 to 63 years, median age 55. Read More

BMC Ophthalmol 2022 Apr 22;22(1):186. Epub 2022 Apr 22.

Department of Ophthalmology, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.

Background: To investigate the safety of vitrectomy with laser photocoagulation in eyes with small peripheral retinal breaks without air or gas tamponade.

Methods: Among patients who underwent vitrectomy for various retinal disorders, those with small peripheral retinal breaks treated by laser photocoagulation without air or gas tamponade were included in this study. Their medical records were assessed retrospectively, and we investigated the characteristics of small peripheral retinal breaks and the incidence of postoperative retinal detachment (RD). Read More

Cureus 2022 Mar 15;14(3):e23201. Epub 2022 Mar 15.

Department of Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Background Even though significant improvements have been made in the field of ophthalmology, retinal detachment is still an ever-increasing issue in both developing and developed countries. The present study evaluated the risk factors of rhegmatogenous retinal detachment (RRD). Methodology A cross-sectional study was conducted at a tertiary care center between June 2020 and March 2021. Read More

Indian J Ophthalmol 2022 Apr;70(4):1280-1285

Department of Ophthalmology, Sant Parmanand Hospital, Delhi, India.

Purpose: To evaluate the prevalence of different types of peripheral retinal changes in a myopic population in North India and correlate them with axial length.

Methods: This cross-sectional, hospital-based survey included 600 eyes of 300 myopic individuals, aged between 10 and 40 years, attending the outdoor ophthalmology clinic of a tertiary eye care hospital in North India were examined from July 2019 to July 2020. They were divided into mild, moderate, high, and severe myopia according to the spherical equivalent of refraction. Read More

Semin Ophthalmol 2022 Mar 7:1-29. Epub 2022 Mar 7.

School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.

Purpose: Certain peripheral retinal degenerations pose a significant risk to vision and require prompt detection and management. Other historically "benign" peripheral lesions are being recognised as clinically significant due to their associations with ocular and systemic disorders. Assessment and documentation of these entities however can be difficult due to challenges in visualisation of the peripheral retina. Read More

Auris Nasus Larynx 2022 Feb 28. Epub 2022 Feb 28.

Department of Otolaryngology, The University of Tokyo, Tokyo, Japan.

Hereditary gelsolin amyloidosis (HGA) is an autosomal dominant systemic amyloidosis, characterized by cranial and sensory peripheral neuropathy, corneal lattice dystrophy, and cutis laxa. We report a case of HGA presenting with bilateral facial palsy. A 70-year-old Japanese man presented with slowly progressive bilateral facial palsy and facial twitching, which had started in his 40s. Read More

Clin Exp Optom 2022 Feb 20:1-4. Epub 2022 Feb 20.

Brien Holden Vision Institute, Sydney, New South Wales, Australia.

Clinical Relevance: Myopia prevention and anti-myopia treatment is of great importance in South East Asia.

Background: To evaluate the prevalence and related factors of myopic retinopathy in Vietnam.

Methods: A cross-sectional study was conducted on 168 eyes of 88 patients with high myopia presenting to the Refraction Department of Vietnam National Eye Hospital. Read More

Clin Ophthalmol 2021 19;15:4739-4745. Epub 2021 Dec 19.

Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Purpose: To investigate whether ultra-widefield (UWF) swept-source optical coherence tomography (SSOCT) system (Silverstone, Nikon Healthcare Japan, Inc, Tokyo, Japan) can obtain OCT images of peripheral retinal degenerations and breaks.

Methods: Thirty-seven eyes of 31 consecutive cases (16 men, 15 women; mean age 51 years) who had peripheral retinal degenerations and underwent a UWF-SSOCT imaging were enrolled. The convenience and usefulness were investigated. Read More

Arq Bras Oftalmol 2021 Nov 29. Epub 2021 Nov 29.

Faculdade de Medicina, Universidade de Passo Fundo, Passo Fundo, RS, Brazil.

Laser photocoagulation is a safe method for the treatment of retinal disorders. We present a case of a 21-year-old woman with high myopia, retinal detachment in the right eye, and bilateral lattice degeneration. She underwent surgical repair in the right eye followed by bilateral retinal laser therapy. Read More

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Nov;52(6):1016-1021

Department of Optometry and Visual Science, West China School of Medicine, Sichuan University, Chengdu 610041, China.

Objective: To investigate the primary diseases and the distribution of the clinical characteristics of pediatric retinal detachment.

Methods: Clinical records of patients aged 0-14 years old who had retinal detachment and who were hospitalized at the Department of Ophthalmology, West China Hospital, Sichuan University between January 2015 and December 2020, were retrospectively analyzed. The information on the demographic data, history, the scope of retinal detachment, and prognosis was retrieved and documented. Read More

Eur Phys J C Part Fields 2021 21;81(7):637. Epub 2021 Jul 21.

Departamento de Física Teórica and IPARCOS, Universidad Complutense, 28040 Madrid, Spain.

We use recently derived Ward identities and lattice data for the light- and strange-quark condensates to reconstruct the scalar and pseudoscalar susceptibilities ( , ) in the isospin 1/2 channel. We show that develops a maximum above the QCD chiral transition, after which it degenerates with . We also obtain within Unitarized Chiral Perturbation Theory (UChPT) at finite temperature, when it is saturated with the (or ) meson, the dominant lowest-energy state in the isospin 1/2 scalar channel of scattering. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Mar 18;260(3):791-798. Epub 2021 Oct 18.

Department of Ophthalmology, Penn State College of Medicine, 500 University Drive, HU19, Hershey, PA, 17033-0850, USA.

Purpose: To compare the incidence rate of delayed retinal break or detachment after diagnosis of acute, symptomatic posterior vitreous detachment (PVD) in a resident-run urgent care clinic (UCC) when staffed by a retina attending, non-retina ophthalmology attending, optometrist, or ophthalmology resident only.

Methods: Retrospective consecutive case series. Of the 594 patients with acute, symptomatic PVD evaluated in the UCC at Penn State Eye Center between 1/1/2016 and 10/10/2019, 454 were included in the study; 140 were excluded because they were diagnosed with a retinal break or detachment on presentation to the UCC, had media opacity precluding examination, or had no follow-up within one year. Read More

Biomater Sci 2021 Oct 26;9(21):7205-7218. Epub 2021 Oct 26.

College of Pharmacy, Jinan University, Guangzhou 510632, PR China.

Osteoarthritis (OA) is a chronic joint disease with occurrence of articular inflammation and cartilage degeneration. An ideal drug delivery system for effective treatment of OA should integrate inflammation alleviation with cartilage protection. Herein, a lyotropic liquid crystal (LLC) precursor co-loading hyaluronic acid (HA) and celecoxib, formulated as the HLC precursor, was developed for the combined therapeutic efficacy. Read More

Radiology 2021 11 7;301(2):423-432. Epub 2021 Sep 7.

From the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).

MRI-based cartilage compositional analysis shows biochemical and microstructural changes at early stages of osteoarthritis before changes become visible with structural MRI sequences and arthroscopy. This could help with early diagnosis, risk assessment, and treatment monitoring of osteoarthritis. Spin-lattice relaxation time constant in rotating frame (T1ρ) and T2 mapping are the MRI techniques best established for assessing cartilage composition. Read More

Ophthalmology 2022 01 27;129(1):67-72. Epub 2021 Jul 27.

Department of Ophthalmology, The Permanente Medical Group, Oakland, California. Electronic address:

Purpose: To evaluate the risk factors for retinal tear (RT) or rhegmatogenous retinal detachment (RRD) associated with acute, symptomatic posterior vitreous detachment (PVD) in a large comprehensive eye care setting.

Design: Retrospective cohort study.

Participants: A total of 8305 adult patients in the Kaiser Permanente Northern California Healthcare System (KPNC) during calendar year 2018 who met inclusion criteria. Read More

Eur J Ophthalmol 2022 May 3;32(3):1642-1651. Epub 2021 Jul 3.

Canon Medical Systems Europe, Business Unit Eye Care, Zoetermeer, Zuid-Holland, The Netherlands.

Purpose: Assess the mid and peripheral neuroretina and vitreoretinal interface using a novel Navigated Single-Capture 3D and Cross-Sectional Wide-Field Swept-Source Optical Coherence Tomography (WF SS-OCT) technology with correlation to Multi-Wavelength Ultra-Widefield Imaging (MW UWFI) and Histopathology reference.

Methods: Retrospective observational study. A total of 74 patients (148 eyes) were imaged using WF SS-OCT and Navigated Single-Capture twelve 23 mm cross-sectional radial scan pattern at 15° intervals. Read More

Cell Mol Life Sci 2021 Jul 3;78(13):5371-5379. Epub 2021 Jun 3.

Nerve Regeneration Group, IBMC- Instituto de Biologia Molecular e Celular and i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135, Porto, Portugal.

The identification of the membrane periodic skeleton (MPS), composed of a periodic lattice of actin rings interconnected by spectrin tetramers, was enabled by the development of super-resolution microscopy, and brought a new exciting perspective to our view of neuronal biology. This exquisite cytoskeleton arrangement plays an important role on mechanisms regulating neuronal (dys)function. The MPS was initially thought to provide mainly for axonal mechanical stability. Read More

BMJ Case Rep 2021 Jun 2;14(6). Epub 2021 Jun 2.

Ophthalmology, Government Medical College and Hospital, Chandigarh, India.

A 7-year-old boy with Marfanoid habitus presented with sudden and painless decrease in the vision of the right eye. Ocular examination revealed rhegmatogenous retinal detachment with 360° giant retinal tear in the right eye and small peripheral retinal breaks with lattice degeneration in the left eye. The patient underwent a 23-gauge pars plana vitrectomy with scleral buckling in the right eye and laser around the breaks in the left eye. Read More

Case Rep Ophthalmol 2021 Jan-Apr;12(1):248-253. Epub 2021 Apr 12.

Department of Surgery, University of Illinois College of Medicine, Peoria, Illinois, USA.

We present 2 cases of iatrogenic retinal penetration from intravitreal (IVT) injections in a retrospective noncomparative case series of 2 patients. The first patient, an 81-year-old Caucasian male, developed dense vitreous hemorrhage soon after receiving an IVT bevacizumab injection for macular edema from central retinal vein occlusion. A 25-g vitrectomy 1 week later showed a retinal hole surrounded by fresh hemorrhages in the same quadrant as the IVT injection. Read More

Case Rep Ophthalmol 2021 Jan-Apr;12(1):219-226. Epub 2021 Apr 12.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.

Purpose: The purpose of this report was to present our findings in 4 cases of rhegmatogenous retinal detachment (RRD) that recurred 10, 11, 12, and 17 years after a reattachment surgery by pars plana vitrectomy (PPV).

Methods: Four cases of a recurrent RRD had undergone scleral buckling surgery and vitrectomy.

Patients: The recurrence of the RRD was observed 10-17 years after the successful attachment by PPV. Read More

Nanomaterials (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Faculty of Physics, Adam Mickiewicz University in Poznań, ulica Uniwersytetu Poznańskiego 2, PL-61614 Poznań, Poland.

The adsorbed atoms exhibit tendency to occupy a triangular lattice formed by periodic potential of the underlying crystal surface. Such a lattice is formed by, e.g. Read More

BMC Ophthalmol 2021 May 2;21(1):195. Epub 2021 May 2.

Department of Ophthalmology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu City, Chiba, 279-0021, Japan.

Background: Sympathetic ophthalmia (SO) is a bilateral diffuse uveitis that can arise after ocular trauma or ocular surgery in the inciting eye. Pars plana vitrectomy (PPV) is one of the risk factors for SO. Several reports have described SO developing after 23- and 25-G PPV, but none have described SO occurring after 27-G PPV. Read More

J Comp Neurol 2021 08 6;529(11):3013-3031. Epub 2021 Apr 6.

Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo, Japan.

Visual opsins are proteins expressed by retinal photoreceptors that capture light to begin the process of phototransduction. In vertebrates, the two types of photoreceptors (rods and cones) express one or multiple opsins and are distributed in variable patterns across the retina. Some cones form opsin retinal gradients, as in the mouse, whereas others form more demarcated opsin domains, as in the lattice-like mosaic retinas of teleost fishes. Read More

Eur J Hum Genet 2021 05 25;29(5):881-886. Epub 2021 Feb 25.

Eye Genetics Research Unit, The Children's Hospital at Westmead, Save Sight Institute, Children's Medical Research Institute, University of Sydney, Sydney, NSW, Australia.

The COL9A3 gene encodes one of the three alpha chains of Type IX collagen, with heterozygous variants reported to cause multiple epiphyseal dysplasia, and suggested as contributory in some cases of sensorineural hearing loss. Patients with homozygous variants have midface hypoplasia, myopia, sensorineural hearing loss, epiphyseal changes and carry a diagnosis of Stickler syndrome. Variants in COL9A3 have not previously been reported to cause vitreoretinal degeneration and/or retinal detachments. Read More

Vestn Oftalmol 2021 ;137(1):46-52

Tradomed Invest JSC, Moscow, Russia.

Purpose: To evaluate the first outcomes of non-contact navigated laser retinopexy for peripheral tears and rhegmatogenous degenerations of the retina.

Material And Methods: This prospective single-center interventional pilot study included 58 patients (68 eyes), among which 19 males and 39 females aged 47.5±16. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Aug 4;259(8):2225-2234. Epub 2021 Feb 4.

Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1# Shuai Fu Yuan, Dongcheng District, Beijing, 100730, China.

Purpose: To investigate the detection of lattice degeneration, retinal breaks, and retinal detachment in tessellated eyes using ultra-wide-field fundus imaging system (Optos) with convolutional neural network technology.

Methods: This study included 1500 Optos color images for tessellated fundus confirmation and peripheral retinal lesion (lattice degeneration, retinal breaks, and retinal detachment) assessment. Three retinal specialists evaluated all images and proposed the reference standard when an agreement was achieved. Read More

Cornea 2021 Mar;40(3):370-372

Fundació de Recerca de l'Institut de Microcirurgia Ocular, Barcelona, Spain.

Purpose: This study aims to clinically and genetically report a case of coexisting Meesmann corneal dystrophy (MECD) and pseudo-unilateral lattice corneal dystrophy (LCD).

Methods: Clinical characterization was supported by a complete ophthalmological evaluation, including visual acuity measurement and slit-lamp examination. Molecular diagnosis was performed by whole-exome sequencing analyzing the gelsolin, keratin K3 (KRT3), keratin K12, and transforming growth factor-beta-induced genes. Read More

Eur J Ophthalmol 2021 May 18;31(3):1475-1478. Epub 2020 Dec 18.

University Hospital Coventry Warwickshire, Coventry, UK.

Introduction: Rhegmatogenous retinal detachment (RRD) is commonly managed by pars plana vitrectomy (PPV). Gas tamponade has significant clinical and quality of life factors that affect the patient. Using shorter acting air tamponade, intuitively leads to surgical concern for higher rate of primary detachment. Read More