Search Our Scientific Publications & Authors

Curr Eye Res 2019 Apr 9. Epub 2019 Apr 9.

a Department of Ophthalmology, Faculty of Medicine , Cairo University , Cairo , Egypt.

Purpose: To determine the prevalence of posterior segment manifestations among consecutive patients with pathological myopia attending our University Hospital general ophthalmology clinic and their association with age, refractive error, axial length and each other.

Methods: Patients diagnosed with pathological myopia underwent full ophthalmological examination, optical coherence tomography, fluorescein angiography, and ocular ultrasonography. Manifestations detected were recorded for each eye and their prevalence and association with age, refractive error, axial length and each other was determined. Read More

Eye (Lond) 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, 200031, Shanghai, China.

Purpose: To evaluate the long-term effect of cataract surgery on highly myopic patients with myopic traction maculopathy (MTM) and the risk factors associated with MTM progression.

Methods: Highly myopic patients with cataract and MTM were included. Phacoemulsification surgery was performed on patients who had vision loss below 20/63 and were willing to operation. Read More

Ophthalmol Retina 2019 Feb 20;3(2):140-145. Epub 2018 Sep 20.

Department of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA.

Objective: To evaluate the outcomes of patients undergoing pneumatic retinopexy (PR) performed by vitreoretinal fellows at 6 academic centers in the United States.

Design: Retrospective, multicenter, consecutive case series.

Participants: 483 patients with primary retinal detachments who underwent PR by 49 vitreoretinal fellows from 6 U. Read More

Retina 2019 Feb 15. Epub 2019 Feb 15.

Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.

Purpose: To determine the preoperative characteristics, intraoperative and postoperative complications, and outcomes of eyes with posteriorly inserted vitreous base.

Methods: In this retrospective, observational, consecutive case series at 2 academic centers, 37 patients were studied who had posteriorly inserted vitreous base noted during vitrectomy. Posteriorly inserted vitreous base was defined as the insertion of the posterior hyaloid membrane being located posterior to the vortex veins. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14271

Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.

Rationale: We experienced 2 cases of retinal detachment (RD) with giant tears located in the intermediate periphery of the fundus. In this case report, we investigated the clinical characteristics in these 2 cases.

Patient Concerns And Diagnoses: Case 1 involved a 63-year-old male, who became aware of metamorphopsia and decreased visual acuity (VA) in his left eye. Read More

Cesk Slov Oftalmol Winter 2018;74(3):108-111

The authors present the ocular finding in a patient sent to the Department of Paediatric Ophthalmology at the Children's University Hospital - Faculty of Medicine, Comenius University in Bratislava at the age of 3 months, with congenital glaucoma in her right eye and bilateral high myopia. The family anamnesis of the patient shows repeated occurrence of stunted growth, myopia, facial dysmorphia and cataract. The child's mother had high myopia, the mother's brother underwent cataract surgery, the child's grandmother and her sisters and the child's great grandmother had high myopia and glaucoma, and probably underwent cataract surgery at a young age. Read More

Eye (Lond) 2019 Jan 7. Epub 2019 Jan 7.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Objectives: To describe the clinical and Scheimpflug imaging features in cases of anterior megalophthalmos (AM).

Methods: Retrospective record review was performed for patients with AM who presented between June 2017 and May 2018. Clinical history, slit lamp examination, Scheimpflug imaging indices (Pentacam-HR, Oculus, GmbH), dilated fundus examination and treatment records were reviewed. Read More

Retin Cases Brief Rep 2019 Winter;13(1):21-24

Vitreo Retina Services, Dr RP Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

Purpose: 1) To evaluate factors governing flow of subretinal fluid and validate Lincoff rules (LRs) in cases of rhegmatogenous retinal detachment. 2) To identify cases of rhegmatogenous retinal detachment where LRs are not followed.

Method: This was a retrospective study where 253 patients of rhegmatogenous retinal detachment were identified through surgery records. Read More

Ophthalmology 2019 Apr 22;126(4):531-539. Epub 2018 Nov 22.

Department of Ophthalmology, St. Michael's Hospital, Toronto, Canada; Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Canada; Kensington Vision and Research Center, Toronto, Canada. Electronic address:

Purpose: The optimal surgery to repair rhegmatogenous retinal detachment (RRD) is unknown. The purpose of this trial was to compare outcomes of pneumatic retinopexy (PnR) versus pars plana vitrectomy (PPV) for the management of primary RRD.

Design: Prospective, randomized controlled trial. Read More

Clin Ophthalmol 2018 9;12:1981-1985. Epub 2018 Oct 9.

Department of Ophthalmology, Toho University Sakura Medical Center, Sakura, Japan,

Purpose: To identify risk factors for retinal breaks during macular hole (MH) surgery.

Patients And Methods: This retrospective, observational, comparative study included the medical records of 364 consecutive patients (382 eyes) who underwent vitrectomy for MH at Toho University Sakura Medical Center between January 2012 and May 2017. The patients comprised 135 men and 229 women with mean age 67. Read More

Adv Colloid Interface Sci 2018 Nov 23;261:102-127. Epub 2018 Aug 23.

Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia; Center for Human Tissues and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; CSIRO Manufacturing, Bayview Avenue, Clayton, Victoria 3168, Australia. Electronic address:

The organization of matter into hierarchical structures is a fundamental characteristic of functional materials and living organisms. Binary colloidal crystal (BCC) systems present a diversified range of nanotopographic structures where large and small colloidal particles simultaneously self-assemble into either 2D monolayer or 3D hierarchical crystal lattices. More importantly, understanding how BCCs form opens up the possibility to fabricate more complex systems such as ternary or quaternary colloidal crystals. Read More

J Formos Med Assoc 2019 Mar 24;118(3):679-685. Epub 2018 Aug 24.

Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan. Electronic address:

Purpose: To investigate the microstructural characteristics of lattice degenerations before and after laser photocoagulation in myopic eyes by spectral-domain optical coherence tomography (SD-OCT).

Methods: Twenty-five eyes of 25 consecutive patients at the High Myopia Clinic of the National Taiwan University Hospital were retrospectively reviewed. Myopic eyes with peripheral lattice degeneration were enrolled in the study. Read More

Am J Ophthalmol 2018 Dec 23;196:82-90. Epub 2018 Aug 23.

Retina Service, Department of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.

Purpose: To evaluate trends for rhegmatogenous retinal detachment (RRD) repair and the influence of patient characteristics on repair type in a large US population including children and adults, between 2003 and 2016.

Design: Retrospective cohort study.

Methods: Setting: Administrative claims for beneficiaries in a large nationwide managed-care network, including Medicare Advantage, employer-sponsored, and commercial insurance. Read More

Int J Ophthalmol 2018 18;11(8):1390-1395. Epub 2018 Aug 18.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China.

Aim: To determine the prevalence and characteristics of peripheral myopic retinopathy among a sample of Guangzhou office workers.

Methods: A cross-sectional study of Guangzhou Chinese office works in different departments and units of the Guangzhou Power Supply Bureau, China, in 2016. Myopic retinopathy was recorded and analyzed with a scanning laser ophthalmoscope and by slit-lamp microscopy combined with a three-mirror contact lens. Read More

Am J Ophthalmol Case Rep 2018 Sep 20;11:119-120. Epub 2018 Jun 20.

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Retin Cases Brief Rep 2018 Aug 6. Epub 2018 Aug 6.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.

Purpose: To report a case of macular vortex vein imaged with indocyanine green angiography, spectral domain optical coherence tomography, and optical coherence tomography angiography.

Methods: Observational case report.

Results: A 51-year-old myopic man presented with the complaint of a floater in his left eye for the previous 2 weeks. Read More

Mol Brain 2018 07 20;11(1):43. Epub 2018 Jul 20.

Molecular Medicine Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Neurofilaments (NFs) are the most abundant cytoskeletal component of vertebrate myelinated axons. NFs function by determining axonal caliber, promoting axonal growth and forming a 3-dimensional lattice that supports the organization of cytoplasmic organelles. The stoichiometry of NF protein subunits (NFL, NFM and NFH) has to be tightly controlled to avoid the formation of NF neuronal cytoplasmic inclusions (NCIs), axonal degeneration and neuronal death, all pathological hallmarks of amyotrophic lateral sclerosis (ALS). Read More

J Ophthalmol 2018 20;2018:2358690. Epub 2018 Jun 20.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Purpose: To determine the prevalence of peripheral retinopathy and its associated risk factors among a sample of Guangzhou office computer workers.

Methods: A cross-sectional study of Guangzhou Chinese computer workstations and operators in different departments and units of the Guangzhou Power Supply Bureau, China, in 2016. Peripheral retinopathy was recorded and analyzed using a scanning laser ophthalmoscope (SLO; Optos, Daytona, United Kingdom) and slit-lamp microscopy combined with a three-mirror contact lens. Read More

Medicine (Baltimore) 2018 Jun;97(22):e10896

Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.

Rationale: The aim of this study was to report a case of Down syndrome (DS) complicated with bilateral retinal detachment (RD) due to unusual retinal degeneration.

Patient Concerns: A 9-year-old girl complained of bilateral visual disturbance during a follow-up examination for myopia and strabismus.

Diagnoses: Slit-lamp examination revealed moderate posterior subcapsular cataract in both eyes. Read More

Retina 2018 May 21. Epub 2018 May 21.

VitreoRetinal Surgery PA, Minneapolis, Minnesota.

Purpose: To determine predictive factors of proliferative vitreoretinopathy (PVR) formation after uncomplicated primary retinal detachment repair.

Methods: Retrospective, single-center, case-control study of 74 consecutive patients with (37 eyes) and without (37 eyes) PVR formation after undergoing uncomplicated primary surgery for retinal detachment repair. Logistic regression was used to assess factors associated with PVR formation. Read More

Opt Lett 2018 May;43(10):2360-2363

We calculated the out-of-plane band structure of a two-dimensional dispersive photonic crystal (PC). To achieve this goal, the plane wave expansion method was implemented in conjunction with a numerical algorithm, the dispersive photonic crystal iterative method. The PC is an array of circular cross-sectional dispersive MgO Lorentz single-pole rods in a square lattice. Read More

Front Cell Neurosci 2018 29;12:90. Epub 2018 Mar 29.

Medical Research Council, Laboratory for Molecular Cell Biology, University College London, London, United Kingdom.

The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. Read More

Invest Ophthalmol Vis Sci 2018 03;59(3):1659-1665

Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States.

Purpose: In cyclic light-reared Pde6brd10 mice, rod cell oxidative stress contributes to the degenerative phenotype. Dark rearing Pde6brd10 mice slows but does not prevent atrophy. This suggests that outer retinal oxidative stress occurs in Pde6brd10 mice independent of light exposure, a hypothesis tested in this study. Read More

Acta Ophthalmol 2018 Nov 25;96(7):e846-e851. Epub 2018 Mar 25.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

Purpose: To determine the type and prevalence of peripheral retinal changes and its relationship with axial length (AL) in a population of young Asian adult males.

Methods: This was a cross-sectional study of male subjects aged between 19 and 25 years old. High myopes [spherical equivalent refraction, (SER) < -6. Read More

Retin Cases Brief Rep 2018 Mar 14. Epub 2018 Mar 14.

Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan.

Purpose: To report a rare case of peripheral retinal neovascularization in a patient diagnosed with cutis marmorata telangiectatica congenita (CMTC).

Methods: Observational case report.

Results: A 16-year-old girl was referred to clinic for retinal evaluation. Read More

NMR Biomed 2018 04 9;31(4):e3893. Epub 2018 Feb 9.

Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.

We have previously reported that the dispersion of spin-lattice relaxation rates in the rotating frame (R ) of tissue water protons at high field can be dominated by chemical exchange contributions. Ischemia in brain causes changes in tissue pH, which in turn may affect proton exchange rates. Amide proton transfer (APT, a form of chemical exchange saturation transfer) has been shown to be sensitive to chemical exchange rates and able to detect pH changes non-invasively following ischemic stroke. Read More

Curr Eye Res 2018 04 28;43(4):539-546. Epub 2017 Dec 28.

a Mossakowski Medical Research Centre , Polish Academy of Sciences , Warsaw , Poland.

Purpose: To establish a relationship between impairment of the anterograde axonal transport (AAT) in the axons of the retinal ganglion cells and the intraocular pressure (IOP) during aging in mice with hereditary glaucoma.

Methods: Quantitative in vivo approach based on manganese enhanced magnetic resonance imaging was developed in order to evaluate AAT in 3-, 6-, and 14-month old DBA/2J mice that develop age-dependent pigmentary glaucoma or age-matched C57Bl/6 mice that do not develop any retinal disease. Unilateral intravitreous administration of MnCl solution was followed 24 h later by MRI performed to obtain spin-lattice relaxation times (T) for regions of interest encompassing the superior colliculi (SC) and the lateral geniculate nuclei (LGN). Read More

Retin Cases Brief Rep 2018 Fall;12 Suppl 1:S81-S86

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.

Purpose: We describe with multimodal imaging the presentation and follow-up for a patient with idiopathic multifocal choroiditis and a transient peripapillary white ring.

Methods: Case report.

Results: A 39-year-old Asian woman was initially seen for an evaluation of lattice degeneration in 2015. Read More

Ocul Oncol Pathol 2017 Sep 23;3(3):235-239. Epub 2017 Mar 23.

Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

Purpose: To report 3 cases providing insight into clinical progression of reactive retinal astrocytic tumor.

Methods: The clinical, imaging, and when available, the cytologic features of 3 cases of reactive retinal astrocytic tumor (focal nodular gliosis) were reviewed.

Results: A 6-year-old female, a 49-year-old man, and a 39-year-old man each developed a white retinal mass associated with laser photocoagulation, lattice degeneration, and treatment of a presumed vascular tumor, respectively. Read More

Ophthalmic Surg Lasers Imaging Retina 2017 10;48(10):856-858

A 63-year-old male presented with a round-shaped floater and visual obscuration in the right eye. Clinical evaluation showed a nonpigmented vitreous cyst connected to a lattice degeneration by a stalk. Immunostaining of the vitreous cyst obtained from vitrectomy showed its origin of retinal neuroepithelium. Read More

ChemSusChem 2018 01 29;11(1):254-263. Epub 2017 Nov 29.

Department of Physics, Harbin Institute of Technology, 92 Xi Dazhi Street, Harbin, Heilongjiang, 150001, P.R. China.

The Nb-doped lanthanum strontium ferrite perovskite oxide La Sr Fe Nb O (LSFNb) is evaluated as an anode material in a solid oxide fuel cell (SOFC). The effects of Nb partial substitution in the crystal structure, the electrical conductivity, and the valence of Fe ions are studied. LSFNb exhibits good structural stability in a severe reducing atmosphere at 800 °C, suggesting that high-valent Nb can effectively promote the stability of the lattice structure. Read More

ACS Appl Mater Interfaces 2017 Oct 20;9(39):33833-33840. Epub 2017 Sep 20.

School of Optical and Electronic Information, Huazhong University of Science and Technology , Wuhan 430074, P. R. China.

Exploring active, stable, earth-abundant, low-cost, and high-efficiency electrocatalysts is highly desired for large-scale industrial applications toward the low-carbon economy. In this study, we apply a versatile selenizing technology to synthesize Se-enriched CoFeSe catalysts on nickel foams for oxygen evolution reactions (OERs) and disclose the relationship between the electronic structures of CoFeSe (via regulating the atom ratio of Co/Fe) and their OER performance. Owing to the fact that the electron configuration of the CoFeSe compounds can be tuned by the incorporated Fe species (electron transfer and lattice distortion), the catalytic activity can be adjusted according to the Co/Fe ratios in the catalyst. Read More

Ophthalmology 2018 01 18;125(1):43-50. Epub 2017 Jul 18.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Purpose: To evaluate the costs and cost-utility of examination for posterior vitreous detachment (PVD) and treatment of associated pathology, and of managing various other peripheral retinal disorders to prevent retinal detachment (RD).

Design: A decision analysis model of cost-utility.

Participants: There were no participants. Read More

Clin Ophthalmol 2017 12;11:1121-1126. Epub 2017 Jun 12.

Eye Department, University of Yaoundé I.

Background: The purpose of this prospective, noncomparative consecutive study was to examine active and retired amateur boxers in order to evaluate the nature and incidence of ocular pathologic conditions related to the boxing practice.

Results: A total of 35 boxers were included in this study. The mean age of the boxers was 28. Read More

Retina 2018 Mar;38(3):578-584

Department of Ophthalmology, Faculty of Medicine, Ege University, Izmir, Turkey.

Purpose: This research investigated the peripheral retinas of patients with central serous chorioretinopathy (CSCR).

Methods: Sixty patients with CSCR and 60 age- and gender-matched controls were included in this prospective cross-sectional study. All 120 participants underwent ocular examinations and peripheral retinal evaluations using a Goldmann three-mirror lens. Read More

Retina 2017 Mar;37(3):585-591

State Key Laboratory of Ophthalmology, Retina Division, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: To report the clinical characteristics of the affected and fellow eyes in patients with familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment (FEVR-RRD).

Methods: This was a retrospective observational case series. The affected and fellow eyes were given complete examinations. Read More

Ophthalmic Surg Lasers Imaging Retina 2017 01;48(1):83-86

A 12-year-old boy presented with a total rhegmatogenous retinal detachment and a giant retinal tear in the right eye. Clinical examination, optical coherence tomography, and fundus images showed an optically empty vitreous, lattice degeneration, and retinoschisis of the macula. Genetic testing revealed mutations in the COL2A1 and RS1 genes, confirming a dual diagnosis of Stickler syndrome and X-linked retinoschisis, respectively. Read More

Int J Ophthalmol 2016 18;9(11):1629-1633. Epub 2016 Nov 18.

Bharti Eye Hospital, New Delhi 110029, India.

Aim: To evaluate the causes and associations of missed retinal breaks (MRBs) and posterior vitreous detachment (PVD) in patients with rhegmatogenous retinal detachment (RRD).

Methods: Case sheets of patients undergoing vitreo retinal surgery for RRD at a tertiary eye care centre were evaluated retrospectively. Out of the 378 records screened, 253 were included for analysis of MRBs and 191 patients were included for analysis of PVD, depending on the inclusion criteria. Read More

Angew Chem Int Ed Engl 2017 01 30;56(2):540-544. Epub 2016 Nov 30.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, P.R. China.

Nitrates have long been ignored for practical uses as nonlinear optical (NLO) materials because they are usually very easy to dissolve in water; despite this, the π-conjugated [NO ] is among the most desirable NLO-active structural units. The cooperation of three structural chromophores, namely, Bi O OH short chains with 6s lone pair electrons, distorted TeO octahedra with d electrons, and π-conjugated [NO ] triangles, generates a new nitrate NLO material, Bi TeO OH(NO ) , which exhibits an enhanced phase-matchable NLO response of three times that of KH PO (3×KH PO ), exceeding those of most nitrate NLO materials. Remarkably, the new material did not show obvious weight loss and degeneration of NLO response after being dipped in de-ionized water for 24 h, indicating that it is highly resistant to water. Read More

J Clin Diagn Res 2016 Jul 1;10(7):ND01-2. Epub 2016 Jul 1.

Medical Director, Bansara Eye Care Centre , Laitumkhrah, Shillong, India .

Lattice degeneration of the retina is not infrequently encountered on a dilated retinal examination and many of them do not need any intervention. We report a case of atypical lattice degeneration variant with peripheral retinal detachment. An asymptomatic 35-year-old lady with minimal refractive error was found to have extensive lattice degeneration, peripheral retinal detachment and fibrotic changes peripherally with elevation of retinal vessels on dilated retinal examination. Read More

J Ophthalmol 2016 13;2016:2193518. Epub 2016 Jul 13.

Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.

Aim. To investigate the anatomical success rates of pars plana vitrectomy (PPV) after primary rhegmatogenous retinal detachment (RRD). Methods. Read More

Nippon Ganka Gakkai Zasshi 2016 May;120(5):382-9

Purpose: To evaluate clinical characteristics of rhegmatogenous retinal detachment in high myopic and phakic eyes.

Subjects And Method: The subjects were 1174 eyes of phakic rhegmatogenous retinal detachment detected in 1199 eyes that underwent initial vitreoretinal surgery between April 2006 and March 2011. Eyes with macular hole retinal detachment or secondary retinal detachment were excluded. Read More

Graefes Arch Clin Exp Ophthalmol 2016 Dec 8;254(12):2333-2338. Epub 2016 Jun 8.

Sunderland Eye Infirmary, Queen Alexandra Road, Sunderland, SR2 9HP, UK.

Purpose: To describe the characteristics and outcomes of patients presenting with rhegmatogenous retinal detachment (RRD) after ocriplasmin (OCP) injection.

Methods: Retrospective, multi-centre, observational case series with case note review.

Results: Eight patients with symptomatic vitreomacular traction (six with concomitant macular hole) were diagnosed with RRD after a median of 16 days (range 3-131 days) post-OCP injection. Read More

Eye Sci 2015 Dec;30(4):156-9

Background: The purpose is to investigate the relationship between full-thickness macular hole (MH) and retinal break (RB) and/or lattice degeneration.

Methods: Patients diagnosed as full-thickness MH and referred to Dr. Lin Lu from January 2009 to December 2013 were evaluated. Read More

Retin Cases Brief Rep 2017 Summer;11(3):255-257

Department of Ophthalmology, Hotel Dieu Hospital, Queen's University, Kingston, ON, Canada.

Background/purpose: To present a case of a patient with simultaneous bilateral retinal detachments treated successfully with bilateral pneumatic retinopexy.

Study Design: Case report.

Results: This is a case of an otherwise healthy 49-year-old woman with no remarkable ocular history that presented with simultaneous phakic superior bilateral rhegmatogenous retinal detachments. Read More

J AAPOS 2016 Apr;20(2):174-7

Department of Ophthalmology, Weill Cornell Medical College, New York, New York; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois. Electronic address:

We report the case of a 2-month-old girl with Dandy-Walker variant who presented with strabismus, pathologic myopia measuring -16.00 D in each eye, diffuse chorioretinal atrophy and pigment mottling in the macula of both eyes, and areas of retinal capillary nonperfusion in both eyes. The patient's brother also has Dandy-Walker variant and was found to have bilateral severe myopia, myopic fundi, tilted optic disks with peripapillary atrophy, extensive areas of white without pressure, areas of lattice degeneration, and several chronic-appearing atrophic retinal holes surrounded by pigmentation. Read More

Cell Rep 2016 Apr 7;15(3):490-498. Epub 2016 Apr 7.

Nerve Regeneration Group, IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4150-180 Porto, Portugal; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal. Electronic address:

The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings. α-adducin knockout mice presented progressive axon enlargement in the spinal cord and optic and sciatic nerves, followed by axon degeneration and loss. Read More

Ophthalmology 2016 06 16;123(6):1368-74. Epub 2016 Mar 16.

Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, Ann Arbor, Michigan; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address:

Purpose: To describe the spectral-domain optical coherence tomography (SD OCT) features of peripheral retinal findings using an ultra-widefield (UWF) steering technique to image the retinal periphery.

Design: Observational study.

Participants: A total of 68 patients (68 eyes) with 19 peripheral retinal features. Read More

PLoS One 2016 24;11(2):e0149176. Epub 2016 Feb 24.

School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

This is an observational study of fluorescein angiography (FA) in consecutive patients with rhegmatogenous retinal detachment (RRD) in Changhua Christian Hospital to investigate the peripheral retinal vascular patterns in those patients. All patients had their age, sex, axial length (AXL), and refraction status (RF) recorded. According to the findings in FA of the peripheral retina, the eyes were divided into 4 groups: in group 1, there was a ramified pattern of peripheral retinal vasculature with gradual tapering; in group 2, there was an abrupt ending of peripheral vasculature with peripheral non-perfusion; in group 3, there was a curving route of peripheral vasculature forming vascular arcades or anastomosis; and in group 4, the same as in group 3, but with one or more wedge-shaped avascular notches. Read More

Cytoskeleton (Hoboken) 2016 Sep 7;73(9):424-34. Epub 2016 Mar 7.

Nerve Regeneration Group, IBMC - Instituto De Biologia Molecular E Celular, Porto, Portugal.

The role of the actin cytoskeleton in neurons has been extensively studied in actin-enriched compartments such as the growth cone and dendritic spines. The recent discovery of actin rings in the axon shaft and in dendrites, together with the identification of axon actin trails, has advanced our understanding on actin organization and dynamics in neurons. However, specifically in the case of actin rings, the mechanisms regulating their nucleation and assembly, and the functions that they may exert in axons and dendrites remain largely unexplored. Read More