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J Biol Regul Homeost Agents 2021 Jun 15;35(3). Epub 2021 Jun 15.

Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

World J Pediatr 2021 Jun 10. Epub 2021 Jun 10.

Department of Clinical Epidemiology and Biostatistics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Asthma has been a global problem, especially in children. We aim to evaluate the contemporary prevalence and influencing factors of asthma among children aged 3-7 years in Shanghai, China.

Methods: A random sample of preschool children was included in this study. Read More

Allergy Rhinol (Providence) 2021 Jan-Dec;12:21526567211009195. Epub 2021 May 26.

Allergy/Immunology Associates Inc, Mayfield Heights, Ohio.

Introduction: Anaphylaxis to jackfruit (Artocarpus heterophyllus) is rare. Two previously reported cases have been published in two healthcare workers from jackfruit endemic regions. Latex allergy and birch pollen cross reactivity have both been associated with jackfruit anaphylaxis, providing two separate mechanisms of sensitization. Read More

Br J Anaesth 2021 May 26. Epub 2021 May 26.

Department of Anaesthesia and Critical Care, Strasbourg University Hospital, Strasbourg, France. Electronic address:

J Investig Allergol Clin Immunol 2021 May 27. Epub 2021 May 27.

Allergology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.

Handb Exp Pharmacol 2021 May 25. Epub 2021 May 25.

Institute for Prevention and Occupational Medicine of the German Statutory Accident Insurance, Institute of the Ruhr University of Bochum (IPA), Bochum, Germany.

Occupational allergies are among the most common recorded occupational diseases. The skin and the upper and lower respiratory tract are the classical manifestation organs. More than 400 occupational agents are currently documented as being potential "respiratory sensitizers" and new reported causative agents are reported each year. Read More

Allergol Immunopathol (Madr) 2021 1;49(3):146-152. Epub 2021 May 1.

Medical School, University of Cyprus, Nicosia, Cyprus.

Introduction And Objectives: In order to investigate food allergy's prevalence, risk factors and eating behavior of children with relevant anamnesis, a study was performed in Cypriot primary schools.

Patients: A specially composed questionnaire for self-reported adverse reactions to food, created in the context of the EuroPrevall study, was distributed in 13 representative primary schools across the country. Participants were sub-grouped into three groups; healthy (H), those with unconfirmed food hypersensitivity reactions (FA) and children with a confirmed diagnosis by a physician IgE-mediated food allergy (FA). Read More

Allergy 2021 Apr 18. Epub 2021 Apr 18.

International Immunology Center, Anhui Agricultural University, Anhui, China.

Background: Allergy is a global disease with overall frequencies of >20%. Symptoms vary from irritating local itching to life-threatening systemic anaphylaxis. Even though allergies are allergen-specific, there is a wide range of cross-reactivities (eg apple and latex) that remain largely unexplained. Read More

Plants (Basel) 2021 Mar 23;10(3). Epub 2021 Mar 23.

Department of Medical Science, Uppsala University, SE 75185 Uppsala, Sweden.

Background: Cultivated buckwheat include two species originating from China: common buckwheat () and tartary buckwheat (). Buckwheat can cause IgE-mediated allergy, including severe allergic reactions and anaphylaxis. Exposure can occure when eating buckwheat food (food allergen), when producing or handling buckwheat food (occupational exposure) or when sleeping on buckwheat husk pillows (houeshold environmental exposure). Read More

Pediatr Allergy Immunol 2021 Mar 27. Epub 2021 Mar 27.

Immunoallergy Department, Centro Hospitalar Lisboa Norte, Hospital Santa Maria, Lisbon, Portugal.

Background: Anaphylaxis is increasing at pediatric age; however, its characterization is hampered by underdiagnosis and underreporting. The aim of this study was to identify the causes of anaphylaxis in children and adolescents in Portugal, thus contributing to a better knowledge of its etiology, clinical manifestations, and management.

Methods: During a 10-year period, a nationwide notification system for anaphylaxis was implemented, with voluntary reporting by allergists. Read More

Pol Przegl Chir 2020 Oct;93(1):9-14

Department of Experimental Surgery, Medical University of Lodz, Poland.

<b>Introduction:</b> The perforation of gloves during surgical procedures is quite common. A cheap and quite effective method of reducing the risk of blood-borne infections is wearing two pairs of gloves. Unfortunately, some surgeons are reluctant to it, and they report decreased dexterity and sensation. Read More

Acta Biochim Pol 2021 Mar;68(1):15-22

Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA.

Timothy grass pollen is a source of potent allergens. Among them, Phl p 1 and Phl p 5 are thought to be the most important, as a majority of timothy grass-allergic individuals have IgE antibodies directed against these two allergens. The profilin from timothy grass (Phl p 12) has been registered as a minor allergen, with up to 35% of individuals in populations of grass pollen allergic patients showing IgE binding to Phl p 12. Read More

Braz J Anesthesiol 2021 Jan-Feb;71(1):76-78. Epub 2020 Dec 28.

Hospital Governador Israel Pinheiro (IPSEMG), Belo Horizonte, MG, Brazil.

Latex responds for most allergic reactions in children, and repeated exposure to the agent is the main cause of sensitization. We report the case of a child allergic to latex who developed anaphylaxis during kidney transplantation performed in a latex-free environment. After immediate treatment with epinephrine the patient gradually improved. Read More

Balkan Med J 2021 03;38(2):73-81

Division of Immunology-Allergy, Department of Internal Medicine, Ege University School of Medicine, İzmir, Turkey.

Angioedema without wheals (urticaria) represents a heterogeneous group of clinically indistinguishable diseases of hereditary or acquired etiology. Hereditary angioedema is a rare inherited condition leading to recurrent, sometimes life-threatening angioedema attacks in subcutaneous tissues and gastrointestinal and oropharyngeal mucosa dating back to childhood or adolescence. Most of these patients have mutations in the SERPING1 gene, causing either low C1 inhibitor production (hereditary angioedema with C1 inhibitor deficiency type I) or the production of dysfunctional C1 inhibitor (hereditary angioedema with C1 inhibitor deficiency type II). Read More

J Allergy Clin Immunol Pract 2021 01;9(1):82-99

Division of Allergy and Immunology, Department of Pediatrics, Elliot and Roslyn Jaffe Food Allergy Institute, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, NY.

The diagnosis and management of food allergy is complicated by an abundance of homologous, cross-reactive proteins in edible foods and aeroallergens. This results in patients having allergic sensitization (positive tests) to many biologically related foods. However, many are sensitized to foods without exhibiting clinical reactivity. Read More

Paediatr Anaesth 2021 Apr 11;31(4):436-443. Epub 2021 Feb 11.

Division of Pediatric Allergy and Asthma Unit, Department of Pediatrics, School of Medicine, Hacettepe University, Sıhhiye, Ankara, Turkey.

Background: Pediatric perioperative hypersensitivity reactions are rare, and possibly life-threatening. Identification of precise etiology is crucial to circumvent future re-exposures.

Aims: We aim to evaluate the clinical features and triggers of perioperative hypersensitivity reactions in children, and determine the outcomes of subsequent general anesthesia. Read More

FEBS J 2021 Jun 6;288(11):3585-3601. Epub 2021 Jan 6.

Department of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, USA.

Transient receptor potential melastatin 7 (TRPM7) is a unique protein functioning as a cation channel as well as a serine/threonine kinase and is highly expressed in immune cells such as lymphocytes and macrophages. TRPM7 kinase-dead (KD) mouse model has been used to investigate the role of this protein in immune cells; these animals display moderate splenomegaly and ectopic hemopoiesis. The basal TRPM7 current magnitudes in peritoneal macrophages isolated from KD mice were higher; however, the maximum currents, achieved after cytoplasmic Mg washout, were not different. Read More

Am J Obstet Gynecol MFM 2020 05 9;2(2):100083. Epub 2020 Jan 9.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine, Houston, TX.

Background: Incidence, risk factors, and perinatal morbidity and mortality rates related to amniotic fluid embolism remain a challenge to evaluate, given the presence of differing international diagnostic criteria, the lack of a gold standard diagnostic test, and a significant overlap with other causes of obstetric morbidity and mortality.

Objective: The aims of this study were (1) to analyze the clinical features and outcomes of women using the largest United States-based contemporary international amniotic fluid embolism registry, and (2) to investigate differences in demographic and obstetric variables, clinical presentation, and outcomes between women with typical versus atypical amniotic fluid embolism, using previously published and validated criteria for the research reporting of amniotic fluid embolism.

Materials And Methods: The AFE Registry is an international database established at Baylor College of Medicine (Houston, TX) in partnership with the Amniotic Fluid Embolism Foundation (Vista, CA) and the Perinatology Research Branch of the Division of Intramural Research of the NICHD/NIH/DHHS (Detroit, MI). Read More

J Pediatr Rehabil Med 2020 ;13(4):601-609

Division of Developmental-Behavioral Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

An estimated 85% of individuals with spina bifida (SB) survive into adulthood, warranting SB-specific transition to adult healthcare guidelines to address the diverse and complex medical, adaptive, and social needs particular to this condition. Latex allergy constitutes one important health concern for this population that requires ongoing and life-long evidence-based management. This article discusses management of latex allergy according to the SB Latex Allergy Healthcare Guidelines from the 2018 Spina Bifida Association's Fourth Edition of the Guidelines for the Care of People with Spina Bifida, reviews current care models in which such latex allergy guidelines can be implemented, and explores further relevant research topics in SB care relative to latex allergy. Read More

Contact Dermatitis 2021 Jun 1;84(6):451-452. Epub 2021 Feb 1.

Department of Dermatology, South Infirmary Victoria University Hospital, Cork, Ireland.

J Allergy Clin Immunol Pract 2021 05 26;9(5):1980-1991. Epub 2020 Nov 26.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass; Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, Mass; Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital, Boston, Mass.

Background: Evidence-based guidelines are needed in the United States to improve evaluation of perioperative allergic reactions including recommendations for subsequent anesthesia.

Objective: To identify causative agent(s) and evaluate patients' tolerability of subsequent anesthesia in patients evaluated by Allergy/Immunology (A/I) at Massachusetts General Hospital.

Methods: We performed a retrospective review of patients referred to the outpatient A/I clinic for perioperative allergic reactions between October 2003 and May 2017. Read More

Br J Nurs 2020 Nov;29(20):1172-1176

Consultant Burns and Plastic Surgeon, University Hospitals Birmingham NHS Foundation Trust.

While it is difficult to imagine that before the late 1800s, surgeons in the theatre environment operated on patients without gloves, gloves are now a clinical necessity. Their use has risen exponentially over the last 30 years, along with concerns over staff and patient allergy and sensitivity to the natural rubber latex proteins used in their manufacture. Having used latex gloves for the better part of 35 years, the author recently evaluated a latex-free alternative. Read More

Paediatr Anaesth 2021 Feb 4;31(2):205-212. Epub 2021 Jan 4.

Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Background: Anaphylactic reactions to antigens in the perioperative environment are uncommon, but they have a potential to lead to serious morbidity and/or mortality. The incidence of anaphylactic reactions is 1:37 000 pediatric anesthetics, and substantially less than the 1:10 000 to 1:20 000 incidence in the adult population. Neuromuscular blocking agents, latex, and antibiotics are the most frequently cited triggers. Read More

J Asthma Allergy 2020 28;13:385-398. Epub 2020 Sep 28.

Allergy Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy.

Allergy to natural rubber latex (NRLA) from is a relevant public health issue, in particular in healthcare workers and groups at risk. Clinical manifestations of NRLA can range from mild skin disorders to life-threatening systemic reactions. Prevention measures remain the gold-standard treatment for patients suffering from NRLA, but the only etiological therapy able to influence the natural history of NRLA is specific desensitization. Read More

Mol Immunol 2020 12 10;128:10-21. Epub 2020 Oct 10.

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Cd. Universitaria, Coyoacán, Ciudad de México, 04510, Mexico. Electronic address:

The production of specific antibodies able to recognize allergens from different sources or block interactions between allergens and antibodies mediating allergic reactions is crucial for developing successful tools for diagnostics and therapeutics. Panallergens are highly conserved proteins present in widely different species, implicated in relevant cross-reactions. The panallergen latex profilin (Hev b 8) has been associated with the latex-food-pollen syndrome. Read More

Ann Work Expo Health 2021 01;65(1):11-25

Department of Dermatology, Zealand University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Roskilde, Denmark.

Objectives: Occupational skin disease (OSD) arises from work-related activity. However, there is a paucity of literature on OSD in physicians. The aim of the this review was therefore to examine and summarize what types of symptomatic OSD physicians experience. Read More

PLoS One 2020 28;15(9):e0239875. Epub 2020 Sep 28.

Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Purpose: To evaluate repeatability, reproducibility, and agreement of intraocular pressure measurement with Tono-Pen using Ocufilm and polyethylene wrap tip cover in human eyes.

Methods: This is a cross-sectional, experimental study. A gas-sterilized, polyethylene wrap was used as an alternative for Tono-Pen tip cover. Read More

PLoS One 2020 16;15(9):e0238296. Epub 2020 Sep 16.

Department of Family and Community Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.

The Quick Environmental Exposure and Sensitivity Inventory (QEESI) is a validated questionnaire used worldwide to assess intolerances to chemicals, foods, and drugs, and has emerged as the gold standard for assessing chemical intolerance (CI). Despite a reported prevalence of 8-33%, epidemiological studies and routine primary care clinics rarely assess CI. To help address this gap, we developed the Brief Environmental Exposure and Sensitivity Inventory (BREESI)-a 3-item CI screening tool. Read More

Arch Argent Pediatr 2020 10;118(5):337-342

Hospital Materno Infantil Ramón Sardá, Ciudad Autónoma de Buenos Aires.

Introduction: International publications estimate a 7 %-17 % latex sensitization (LS) prevalence among health care workers, but values in Argentina are unknown.

Objectives: To estimate the prevalence of latex sensitization and allergy among residents of a children's hospital using the immediate-reading prick test and to assess associated risk factors in this population.

Population And Methods: Cross-sectional study. Read More