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Allergy Asthma Clin Immunol 2019 29;15:19. Epub 2019 Mar 29.

1Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Natural rubber latex and chlorhexidine have previously been identified as causative substances in perioperative anaphylaxis. A pelvic examinations is generally considered noninvasive, however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of dual latex and chlorhexidine allergies which caused anaphylaxis after pelvic examination in a woman with a history of latex-related fruits allergy. Read More

J Diabetes Res 2019 3;2019:7457295. Epub 2019 Mar 3.

Postgraduate Program in Biomedical Engineering-PPGEB at Gama-FGA, University of Brasília-UnB, Brasília 72.444-240, Brazil.

Wound healing is a perfectly coordinated cascade of cellular, molecular, and biochemical events which interact in tissue reconstitution. Chronic diseases such as pressure ulcers (PU) and diabetes mellitus (DM) are considered risk factors for wound healing. Patients with such diseases often have higher sepsis, infection, and complication rates, since they have revascularization inhibition and low growth factor expression. Read More

Br J Anaesth 2019 Mar 4. Epub 2019 Mar 4.

Allergy Unit, S. Martino Policlinic Hospital, Genoa, Italy.

Suspected perioperative hypersensitivity reactions are rare but contribute significantly to the morbidity and mortality of surgical procedures. Recent publications have highlighted the differences between countries concerning the respective risk of different drugs, and changes in patterns of causal agents and the emergence of new allergens. This review summarises recent information on the epidemiology of perioperative hypersensitivity reactions, with specific consideration of differences between geographic areas for the most frequently involved offending agents. Read More

Br J Anaesth 2019 Feb 11. Epub 2019 Feb 11.

Department of Immunology, Allergology, and Rheumatology, University Antwerp, Antwerp University Hospital, Antwerp, Belgium.

Correct diagnostic management of perioperative hypersensitivity aims to identify the underlying mechanism(s), responsible culprit(s), and safe alternative drugs or techniques. Although drug provocation tests are considered the gold standard, diagnosis of perioperative hypersensitivity mainly relies on skin testing. Use of in vitro tests, such as quantification of specific immunoglobulin E antibodies, serum tryptase, and plasma histamine, as well as basophil activation tests is becoming widespread. Read More

Curr Opin Allergy Clin Immunol 2019 Mar 15. Epub 2019 Mar 15.

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.

Purpose Of Review: Occupation is an important contributing factor in the presentation of allergic disease in adults. This review article focuses on the contribution of occupation to the development and presentation of food allergies.

Recent Findings: A variety of occupations involve repeated transdermal and respiratory exposures to food-related allergens, which can result in sensitization. Read More

J Allergy Clin Immunol Pract 2019 Mar 8. Epub 2019 Mar 8.

Department of Immunology, Allergology, Rheumatology, Faculty of Medicine and Health Sciences, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.

Background: Despite numerous efforts to describe the clinical manifestations and the epidemiology of perioperative hypersensitivity (POH), there remains room to increase awareness among anesthetists and immunologists/allergists.

Objective: To report the findings of a 17-year survey of suspected POH in Antwerp, Belgium.

Methods: We analyzed clinical and diagnostic data from 715 patients referred because of a suspected POH reaction, between January 1, 2001, and May 31, 2018. Read More

Ann Allergy Asthma Immunol 2019 Mar 8. Epub 2019 Mar 8.

Research Unit for Mathematical Sciences, University of Oulu, Oulu, Finland.

Background: The temporal sequence in which allergic sensitization to different allergens emerges is not well characterized at the level of general population.

Objective: We describe the incidence patterns of atopic sensitization to different allergens from birth up to 12 years of age in an unselected Finnish population.

Methods: The study population comprised all children born between 2001 and 2006 identified from the nationwide population register as residents of the province of South Karelia, Finland (n = 5564). Read More

Int Arch Allergy Immunol 2019 8;178(4):345-354. Epub 2019 Mar 8.

Allergy Clinic, Department of Dermatology and Allergy, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: In pollen-allergic patients, cross-reacting allergens including cross-reactive carbohydrate determinants (CCDs) and profilins may result in positive natural rubber latex (NRL)-specific IgE (sIgE) antibody tests but the relationship between this sensitization and clinical NRL type 1 allergy is poorly described.

Objective: The aims of this study were to determine the frequency and clinical relevance of NRL sIgE in grass pollen-sensitized individuals and to investigate which NRL allergen components these individuals were sensitized to.

Methods: A total of 383 grass-sensitized patients answered questions about NRL allergy symptoms and their stored sera from previous investigations were analyzed for NRL sIgE. Read More

Med Pr 2019 Mar;70(1):121-124

University of Rome “Tor Vergata,” Rome, Italy (Department of Occupational Medicine)

Contact dermatitis is a major problem in the healthcare environment and in other sectors. Healthcare professionals may be exposed to a large number of chemical agents, including the accelerators for rubber vulcanization process. The prevalence of allergic contact dermatitis among operators in the sector ranges 13–30%. Read More

Eur J Anaesthesiol 2019 Apr;36(4):312-313

Food Chem 2019 Jun 25;284:245-253. Epub 2019 Jan 25.

Universidade Federal do Ceará, Departamento de Bioquímica e Biologia Molecular, Fortaleza, Ceará CEP 60.440-970, Brazil. Electronic address:

The present study evaluated four laticifer fluids as a novel source of peptidases capable of hydrolyzing proteins in cow's milk. The latex peptidases from Calotropis procera (CpLP), Cryptostegia grandiflora (CgLP), and Carica papaya (CapLP) were able to perform total hydrolysis of caseins after 30 min at pH 6.5, as confirmed by a significant reduction in the residual antigenicity. Read More

J Patient Saf 2019 Jan 31. Epub 2019 Jan 31.

Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital and the Massachusetts General Professional Organization.

Background: The epidemiology of hospital adverse reactions (ARs), particularly allergic reactions, or hypersensitivity reactions (HSRs), is poorly defined. To determine priorities for allergy safety in healthcare, we identified and described safety reports of allergic reactions.

Methods: We searched the safety report database of a large academic medical center from April 2006 to March 2016 using 101 complete, truncated, and/or misspelled key words related to allergic symptoms, treatments, and culprits (e. Read More

Neurogastroenterol Motil 2019 Apr 31;31(4):e13552. Epub 2019 Jan 31.

Department of Gastroenterology, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.

Background: Anorectal manometry (ARM) and balloon expulsion test (BET) are pivotal in investigation of anorectal disorders. There is controversy, however, about normal values and optimum methodology for performing these tests. Our aims were to compare BET using three different balloons and to establish normal values for ARM and BET in health. Read More

Eur Ann Allergy Clin Immunol 2018 Nov 24;50(6):281-282. Epub 2018 Oct 24.

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (MI), Italy.

Rev Alerg Mex 2018 Oct-Dec;65(4):379-388

Secretaría de Salud, Hospital General de México, Servicio Alergia e Inmunología Clínica, Ciudad de México, México.

Background: Perioperative hypersensitivity reactions constitute a global health problem, with an estimated incidence of 1 per 100,000 procedures and a mortality rate of 0.1 to 9 %. Main risk factors are a history of allergy to other drugs, atopy, associated psychiatric disorders and previous surgeries. Read More

Curr Opin Allergy Clin Immunol 2019 Apr;19(2):92-97

Department of Occupational Lung Disease, Royal Brompton Hospital, London SW3 6LR.

Purpose Of Review: There is an unmet need for better immunological tests in cases of suspected occupational asthma to many workplace chemicals; here we consider the basophil activation test (BAT), a potential alternative to the detection of specific IgE antibodies.

Recent Findings: BAT is fairly widely used in general allergy services; and there is increasing experience of its use in the diagnosis of occupational allergy to low molecular weight agents and chemicals including wood dusts, persulphates, antibiotics and latex.

Summary: There is potential for BAT to become a useful tool in the clinical consideration of occupational asthma and of its mechanisms, and even to take a place in a Bayesian-based diagnostic algorithm. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13293

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital.

There is an increase in prevalence and financial burden of childhood atopic disorders in recent years. Understanding allergic conditions of pregnant women is important for developing strategies for prevention and management of allergy-related diseases. However, little is currently known about the atopic conditions in pregnant women. Read More

Paediatr Anaesth 2019 Feb 19;29(2):153-160. Epub 2018 Dec 19.

Department of Anaesthesia and Pain Management, Perth Children's Hospital, Perth, Australia.

Background And Aim: Pediatric patients increasingly report allergies, including allergies to food and medications. We sought to determine the incidence and, nature of parent-reported allergies in children presenting for surgery and its significance for anesthetists.

Methods: We prospectively collected data on admissions through our surgical admission unit over a 2-month period at a pediatric tertiary care teaching hospital. Read More

Pediatr Transplant 2019 02 4;23(1):e13316. Epub 2018 Nov 4.

Division of Pediatric Cardiology, Department of Pediatrics, Stanford University Medical Center, Palo Alto, California.

Background: Pediatric heart transplant (PedHtx) patients have increased cardiovascular risk profiles that affect their long-term outcomes and quality of life. We designed a 12- to 16-week diet and exercise intervention delivered via live video conferencing to improve cardiovascular health. Our methodology and baseline assessment of the first 13 enrolled patients are reported. Read More

Open Access Maced J Med Sci 2018 Sep 23;6(9):1722-1726. Epub 2018 Sep 23.

College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Aim: The present study was aimed to assess the level of awareness and occupational hazards of dental students and professionals who are working at dental college and hospital, Jazan University, Saudi Arabia.

Material And Methods: Data has been collected through a self-administrated questionnaire with closed questions. The questionnaire consisted of questions on personal information like age, gender, years of experience and awareness of occupational hazards, seminar attendance, safety measures practised, and experience of occupational hazard while in practice. Read More

J Med Invest 2018 ;65(3.4):292-295

Department of Pediatrics, Tokushima University.

Natural rubber latex (NRL) allergy is one of the most important causes of severe anaphylaxis during medical intervention. We report a pediatric case of latex allergy with multiple surgical histories. A 12-year-old girl developed anaphylactic shock during the pyeloplasty for ureteropelvic junction restenosis. Read More

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):1877-1878. Epub 2018 Sep 21.

Division of Allergy/Immunology/Rheumatology, Department of Pediatrics, University of North Carolina-Chapel Hill, Chapel Hill, NC. Electronic address:

Reduction in the prevalence of IgE-mediated allergy to latex proteins from gloves in patients may lead to lax attention by health care personnel to avoid use of latex products in latex-allergic subjects. Recent evidence from the Pennsylvania Patient Safety Reporting System shows an alarming continuation of adverse events mostly from latex urinary catheters. We are strongly advocating that health care personnel must continue to pay close attention to avoidance of latex in patients with a history of latex allergy. Read More

Front Pediatr 2018 7;6:236. Epub 2018 Sep 7.

Department of Research and Diagnostics, Istituto G. Gaslini, Genoa, Italy.

During general anesthesia, while muscle relaxants, latex and antibiotics are normally considered as very common causes of anaphylactic reactions, there are no documented cases of anaphylaxis due to inhalational agents. We report the case of a 6-year-old child scheduled for adenotonsillectomy who had an anaphylactic shock reaction due to Sevoflurane. Several allergic tests were performed to detect the trigger. Read More

Mol Immunol 2018 11 19;103:89-95. Epub 2018 Sep 19.

Institute of Biosciences and BioResources, CNR, I-80131 Naples, Italy. Electronic address:

Allergy to pomegranate is often associated with severe symptoms. Two allergens have previously been described: 9k-LTP Pun g 1 and pommaclein Pun g 7. This study describes the isolation of a chitinase III, identified by direct protein sequencing and mass spectrometry. Read More

Cutis 2018 Aug;102(2):116-118

Department of Dermatology, Loma Linda University, California, USA.

An allergic reaction provoked by reexposure to an allergen or antigen is known as a type I or immediate hypersensitivity reaction. Latex allergy is a common cause of type I hypersensitivity reactions. Allergic responses to latex in psoriasis patients receiving frequent injections with biologic agents are not commonly reported in the literature. Read More

Int Arch Allergy Immunol 2019;178(1):83-88. Epub 2018 Sep 13.

Department of Dermatology, Venereology, and Allergology, University Medical Center, Georg August University, Göttingen,

Background: Natural rubber latex (NRL) allergy is commonly diagnosed according to medical history, skin allergy tests, and serological analyses. However, skin tests are increasingly being abandoned because of (i) their time-consuming nature, (ii) latex preparations for skin tests being not commercially available, and (iii) the use of in-house prepared test solutions is becoming ever more difficult due to increasing regulatory hurdles. In this light, we have evaluated differences in the profiles of current and former patients with suspected latex allergy. Read More

Allergol Immunopathol (Madr) 2019 Jan - Feb;47(1):12-15. Epub 2018 Sep 5.

Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus.

Introduction And Objectives: Profilin is a panallergen contained in pollen, plant foods and latex. Although cross-reactivity is expected while performing skin prick tests (SPT) with allergens that contain profilin, this is not always noticed. The purpose of this study was to detect if profilin is contained in the commercial SPT extracts of pollen and plant foods which, in their fresh form, contain determined epitopes of profilin. Read More

Int J Food Microbiol 2019 Jan 28;289:7-16. Epub 2018 Aug 28.

Laboratorio de Bioquímica y Biología Molecular, Departamento de Biología, Universidad de La Serena, La Serena, Chile; Millennium Nucleus for Fungal Integrative and Synthetic Biology (FISB), Chile. Electronic address:

The aim of this study was to determine the antifungal activity of the proteolytic fraction P1G10 from Vasconcellea cundinamarcencis (ex-Carica candamarcensis) against Botrytis cinerea, the causative agent of pre- and postharvest damaging disease in fruit and vegetables. The survival of B. cinerea at different concentrations of P1G10 showed that 1 mg/mL inhibited 50% of mycelium growth after 72 h incubation. Read More

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):1813-1823. Epub 2018 Aug 29.

Faculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium. Electronic address:

Secondary food allergies due to cross-reactivity between inhalant and food allergens are a significant and increasing global health issue. Cross-reactive food allergies predominantly involve plant-derived foods resulting from a prior sensitization to cross-reactive components present in pollen (grass, tree, weeds) and natural rubber latex. Also, primary sensitization to allergens present in fungi, insects, and both nonmammalian and mammalian meat might induce cross-reactive food allergic syndromes. Read More

Ann R Coll Surg Engl 2019 Feb 16;101(2):134-135. Epub 2018 Aug 16.

Norfolk and Norwich University Hospitals NHS Foundation Trust , Norwich , UK.

J Investig Allergol Clin Immunol 2018 Aug;28(4):269-271

Department of Biomedical Sciences and Human Oncology Unit of Internal Medicine "G. Baccelli" 8, "Aldo Moro" University of Bari Medical School, Policlinico, Bari, Italy.

Clin Mol Allergy 2018 9;16:16. Epub 2018 Jul 9.

2Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari-Aldo Moro, Bari, Italy.

Adverse reactions (ARs) to drugs administered during general anesthesia may be very severe and life-threatening, with a mortality rate ranging from 3 to 9%. The adverse reactions to drugs may be IgE and non-IgE-mediated. Neuromuscular blocking agents (NMBA) represent the first cause of perioperative reactions during general anesthesia followed by latex, antibiotics, hypnotic agents, opioids, colloids, dyes and antiseptics (chlorhexidine). Read More

Rev Alerg Mex 2018 Apr-Jun;65(2):128-139

Instituto Mexicano del Seguro Social, Hospital General de Zona 30, Mexicali, Baja California, México.

Background: The prevalence of latex allergy ranges from 0.8 to 6.5% and is the second cause of perioperative anaphylaxis. Read More

Int Arch Allergy Immunol 2018;177(3):238-244. Epub 2018 Jul 5.

Clinical Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Background: Dental workers often experience unwanted allergic and nonallergic skin reactions resulting in different contact dermatoses (e.g., contact urticaria, irritant and allergic contact dermatitis) that are often attributed to rubber gloves. Read More

Br J Anaesth 2018 Jul 21;121(1):159-171. Epub 2018 May 21.

Medicines and Healthcare products Regulatory Agency, London, UK.

Background: Anaphylaxis during anaesthesia is a serious complication for patients and anaesthetists.

Methods: The 6th National Audit Project (NAP6) on perioperative anaphylaxis collected and reviewed 266 reports of Grades 3-5 anaphylaxis over 1 yr from all NHS hospitals in the UK.

Results: The estimated incidence was ≈1:10 000 anaesthetics. Read More

Br J Anaesth 2018 Jul 21;121(1):146-158. Epub 2018 May 21.

Manchester University NHS Foundation Trust, Manchester, UK; Manchester Academic Heath Science Centre, University of Manchester, Manchester, UK; Royal College of Anaesthetists, London, UK.

Background: Details of the current UK drug and allergen exposure were needed for interpretation of reports of perioperative anaphylaxis to the 6th National Audit Project (NAP6).

Methods: We performed a cross-sectional survey of 356 NHS hospitals determining anaesthetic drug usage in October 2016. All cases cared for by an anaesthetist were included. Read More

Sao Paulo Med J 2018 Jun 11. Epub 2018 Jun 11.

MD, PhD. Attending Physician, Clinical Immunology and Allergy Division, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo (SP), Brazil.

Context: Adverse reactions associated with prick tests are rare but may be present as serious systemic reactions.

Case Report: A 38-year-old female nursing technician complained of three episodes of anaphylaxis in one year, all in the workplace. To investigate latex allergy, the patient underwent the prick test with latex, and immediately developed a rash, itchy skin, hoarseness, dyspnea and dry cough. Read More

J Allergy Clin Immunol Pract 2019 Jan 23;7(1):300-302. Epub 2018 May 23.

Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Bari, Italy. Electronic address:

J Oncol Pharm Pract 2019 Jun 23;25(4):1016-1020. Epub 2018 May 23.

7 Unidad de Reumatología. UGC Cirugía Ortopédica, Traumatología y Reumatología, Hospital Universitario Puerta del Mar, Cádiz, Spain.

We describe a successful desensitization to alemtuzumab in one patient diagnosed with T-cell prolymphocytic leukaemia. Alemtuzumab treatment was initiated during infusion number 18, the patient showed cutaneous eruption with a miliary pattern, despite premedication with corticosteroids and antihistamines. The eruption returned with successive alemtuzumab infusions (infusions 19, 20 and 21), remained present for longer and was more severe with each infusion. Read More

Clin Exp Allergy 2018 Jul 19;48(7):846-861. Epub 2018 Jun 19.

Manchester University NHS Foundation Trust, Manchester, UK.

Background: The Royal College of Anaesthetists 6th National Audit Project examined Grade 3-5 perioperative anaphylaxis for 1 year in the UK.

Objective: To describe the causes and investigation of anaphylaxis in the NAP6 cohort, in relation to published guidance and previous baseline survey results.

Methods: We used a secure registry to gather details of Grade 3-5 perioperative anaphylaxis. Read More

BMC Pregnancy Childbirth 2018 May 15;18(1):168. Epub 2018 May 15.

Division of Global Health and Human Rights, Department of Emergency Medicine, Massachusetts General Hospital, 125 Nashua St, Suite 910, Boston, MA, 02114, USA.

Background: Postpartum hemorrhage is the leading cause of maternal mortality in low- and middle-income countries. While evidence on uterine balloon tamponade efficacy for severe hemorrhage is encouraging, little is known about safety of this intervention. The objective of this study was to evaluate the safety of an ultra-low-cost uterine balloon tamponade package (named ESM-UBT) for facility-based management of uncontrolled postpartum hemorrhage (PPH) in Kenya and Sierra Leone. Read More

Dermatitis 2018 May/Jun;29(3):176

Postepy Dermatol Alergol 2018 Apr 24;35(2):145-150. Epub 2018 Apr 24.

Allergy Unit, Università Cattolica del Sacro Cuore - Fondazione Policlinico "A. Gemelli", Rome, Italy.

Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization.

Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years.

Material And Methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy. Read More

Rev Alerg Mex 2018 Jan-Mar;65(1):10-18

Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Servicio de Alergia e Inmunología Clínica, Guadalajara, Jalisco, México.

Background: Prevalence of latex allergy in medical students is not known.

Objective: To determine the prevalence of self-reported latex allergy and associated factors in medical students.

Methods: Cross-sectional, analytical study of students with or without self-reported latex allergy. Read More

Rev Alerg Mex 2018 Jan-Mar;65(1):3-9

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica. Ciudad de México, México.

Background: Latex-fruit syndrome (LFS) is characterized by allergy to latex and plants. Papain, chymopapain, caricaine and class I chitinases are papaya's most allergenic proteins. The similarity between latex hevein epitopes and papaya class I chitinases might explain the latex-papaya syndrome (LPS). Read More

Mol Immunol 2018 08 9;100:21-27. Epub 2018 Apr 9.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany. Electronic address:

We are now in the epoch of "molecular allergology" and numerous clinically relevant allergenic molecules are available improving the performance of in vitro allergen tests and allergen detection methods. This review is focusing on characterized occupational allergens and their implementation into the in vitro diagnosis for occupational allergy and in allergen detection methods. More than 400 occupational agents are identified and documented as being 'respiratory sensitizers', but currently only a limited number of them are characterized on the molecular level and available for routine diagnosis as native or recombinant allergens. Read More

Curr Opin Allergy Clin Immunol 2018 06;18(3):168-176

Department of Philosophical, Methodological and Experimental Disciplines, University of Guadalajara, Guadalajara, Mexico.

Purpose Of Review: Allergen immunotherapy (AIT) is a well recognized and extensively studied therapeutic intervention for some allergic diseases. Every year new systematic reviews and meta-analysis provide the most powerful source of evidence to orient decision making on prevention or efficacy of AIT. We here discuss systematic reviews and meta-analyses on AIT (published January 2017 to February 2018). Read More

Int Arch Allergy Immunol 2018 28;176(1):1-7. Epub 2018 Mar 28.

Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, Turkey.

Background: It has been suggested that latex-specific IgE analysis may lead to false-positive results, especially in patients with pollen allergy. In the present study, the reasons underlying clinically irrelevant latex-specific IgE positivity were investigated.

Methods: Thirty patients with latex allergy (group 1), 89 patients sensitised to aeroallergens (group 2a), and 98 healthy individuals without allergy (group 2b) were enrolled. Read More

Ann Allergy Asthma Immunol 2018 05 23;120(5):468-475. Epub 2018 Mar 23.

Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

Food Chem Toxicol 2018 May 24;115:365-374. Epub 2018 Mar 24.

Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran. Electronic address:

Plant-derived foods are the most common allergenic sources in adulthood. Owing to the rapidly increasing prevalence of plant food allergies in industrialized countries, the environmental factors are suspected to play a key role in development of allergic sensitization. The present article provides an overview of ways by which chemicals may influence the development and severity of allergic reactions to plant foods, with especial focus on plant allergens up-regulated under chemical stress. Read More