Search Our Scientific Publications & Authors

Compr Psychoneuroendocrinol 2021 Nov 23;8:100096. Epub 2021 Oct 23.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, And Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.

Early-onset (EOD) and late-onset (LOD) late-life depression might differ in etiology, clinical features, and treatment response. While EOD is more frequently associated with a family history of affective disorders and personality aspects, LOD is thought to be more strongly driven by acquired cerebrovascular risk factors associated with vascular pathology, executive dysfunction, and poor treatment response. However, in a systematic review, EOD and LOD only differed in the frequency of affective disorders in the family history. Read More

Psychiatry Res 2022 May 4;314:114601. Epub 2022 May 4.

Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Department of Psychiatry and Legal Medicine, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Laboratory of Molecular Psychiatry, Experimental Research Center, Clinical Hospital (CPE-HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Avenue Ramiro Barcelos, Porto Alegre, RS CEP 90035-903, Brazil; Post-Graduation Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; National Institute for Science and Technology in Translational Medicine (INCT-TM), CNPq, FAPESP, CAPES, Brazil. Electronic address:

Major depressive disorder (MDD) is a common condition that affects the general population over a wide range of ages, regardless of gender and social background. Early-onset of MDD in adulthood, between ages of 18 and 30 years, is associated with worse outcomes and increased years of disability. Stress load and physical health have been associated with age of onset in MDD. Read More

Metab Brain Dis 2022 Jun 15. Epub 2022 Jun 15.

School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, SA, Australia.

Most Alzheimer disease (AD) patients present as sporadic late onset AD, with metabolic factors playing an important role in the occurrence and development of AD. Given the link between peripheral insulin resistance and tau pathology in streptozotocin-injected and db/db mouse models of diabetes, we fed high fat diet (HFD) to pR5 mice expressing P301L mutant human tau, with the aim of developing a new model with characteristics of obesity, T2DM and AD to mimic AD patients exacerbated by obesity and T2DM, an increasing trend in modern society. In our study, pR5 and C57BL/6 (WT) mice were randomly allocated to a standard diet (STD) or HFD for 30 weeks starting at 8 weeks of age. Read More

Respir Med Res 2022 Feb 3;82:100888. Epub 2022 Feb 3.

Groupe Hospitalier de la Région Mulhouse Sud-Alsace, Hôpital Émile Muller, Service de Pneumologie, Mulhouse, France.

Background: Obstructive sleep apnoea syndrome (OSAS) and severe asthma are frequently associated. This article focuses on the relationship between severe asthma phenotypes and OSAS.

Methods: FASE-CPHG was an observational, cross-sectional, prospective, multicentric study conducted in 104 non-academic hospitals from May-16 to July-17. Read More

J Ethn Subst Abuse 2022 Jun 9:1-22. Epub 2022 Jun 9.

Bahcesehir University, Istanbul, Turkey.

The onset of substance use is a strong predictor of substance use disorders and related problems. This study examined the differences between early- and late-onset substance use in personality and substance use characteristics, traumatic experiences, and social support with a sample of 100 Turkish adults with substance use disorders. Early onset (<18 years) was associated with more traumatic experiences, increased risk of developing posttraumatic stress disorder (PTSD), and higher levels of depressive symptoms compared to late onset (≥18 years). Read More

Encephale 2022 06;48(3):229-231

AP-HM, Aix-Marseille University, CEReSS-Health Service Research and Quality of Life Center, 27, boulevard Jean-Moulin, 13005 Marseille, France. Electronic address:

Front Genet 2022 17;13:794202. Epub 2022 May 17.

Department of Biostatistics, School of Public Health, Peking University, Beijing, China.

Late-onset Alzheimer's disease (AD) is associated with sleep-related phenotypes (SRPs). The fact that whether they share a common genetic etiology remains largely unknown. We explored the shared genetics and causality between AD and SRPs by using high-definition likelihood (HDL), cross-phenotype association study (CPASSOC), transcriptome-wide association study (TWAS), and bidirectional Mendelian randomization (MR) in summary-level data for AD ( = 455,258) and summary-level data for seven SRPs (sample size ranges from 359,916 to 1,331,010). Read More

JMIR Mhealth Uhealth 2022 May 23;10(5):e34154. Epub 2022 May 23.

National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira, Japan.

Background: Adolescent health promotion is important in preventing risk behaviors and improving mental health. Health promotion during adolescence has been shown to contribute to the prevention of late onset of the mental health disease. However, scalable interventions have not been established yet. Read More

Psychiatry Res 2022 07 16;313:114640. Epub 2022 May 16.

UCLA/Duke University National Center for Child Traumatic Stress, Department of Psychiatry and Biobehavioral Sciences, UCLA, CA, USA; Collaborative Neuroscience Network, CA, USA.

There is a scarcity of long-term studies of depression after natural disasters. This prospective epidemiologic study evaluated the course of depression and factors associated with it among survivors 23-years post-earthquake. A geographically stratified subsample of 725 adults exposed to the Spitak earthquake was assessed for depression using DSM-III-R criteria in 1991 and 2012. Read More

Andrologia 2022 May 20:e14472. Epub 2022 May 20.

Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

The current study was aimed at analysing the clinical features and efficacy of combined treatments in patients with sleep-related painful erection (SRPE). Patients who presented with SRPE were continuously enrolled from the outpatient clinic of Peking Union Medical College Hospital from 2015 to 2021. Demographic data, medical history, diagnostics, treatment options and their effectiveness on SRPE in the short and long therapeutic term were recorded. Read More

J Psychiatry Neurosci 2022 May-Jun;47(3):E186-E193. Epub 2022 May 4.

From the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan

Background: Frontal asymmetry plays a major role in depression. However, patients with treatment-resistant depression (TRD) have widespread hypofrontality. We investigated whether patients with TRD have a characteristic frontal activation pattern in functional near-infrared spectroscopy (fNIRS) findings and how the frontal cortex responds to different levels of cognitive tasks. Read More

Orphanet J Rare Dis 2022 04 27;17(1):177. Epub 2022 Apr 27.

Institute of Neuropathology, Justus Liebig University Giessen, Arndstr.16, 35392, Giessen, Germany.

Background: Pain occurs in the majority of patients with late onset Pompe disease (LOPD) and is associated with a reduced quality of life. The aim of this study was to analyse the pain characteristics and its relation to a small nerve fiber involvement in LOPD patients.

Methods: In 35 patients with LOPD under enzyme replacement therapy without clinical signs of polyneuropathy (19 females; 51 ± 15 years), pain characteristics as well as depressive and anxiety symptoms were assessed using the PainDetect questionnaire (PDQ) and the hospital anxiety and depression scale (HADS), respectively. Read More

Addiction 2022 Apr 26. Epub 2022 Apr 26.

Department of Social Work, Umeå University, Umeå, Sweden.

Background And Aims: Older people with problematic alcohol use vary in psychosocial functioning, age of onset for problem drinking and use of other drugs. The study measured the differential risks of all-cause, alcohol-, polydrug- and psychiatric-related repeated hospitalizations among older people with problematic alcohol use.

Design: A linked register-based cohort study with discontinuous multiple-failure (time-to-repeated-event) data. Read More

Front Psychol 2022 7;13:849847. Epub 2022 Apr 7.

Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background: Neurobiological mechanisms underlying the recurrence of major depressive disorder (MDD) at different ages are unclear, and this study used the regional homogeneity (ReHo) index to compare whether there are differences between early onset recurrent depression (EORD) and late onset recurrent depression (LORD).

Methods: Eighteen EORD patients, 18 LORD patients, 18 young healthy controls (HCs), and 18 older HCs were included in the rs-fMRI scans. ReHo observational metrics were used for image analysis and further correlation of differential brain regions with clinical symptoms was analyzed. Read More

Biochem Med (Zagreb) 2022 Jun 15;32(2):020802. Epub 2022 Apr 15.

Clinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.

Vitamin B12 deficiency can present with neurologic and psychiatric symptoms without macrocytic anaemia. We describe a case of late-onset cobalamin C deficiency which typically presents with normal serum vitamin B12 concentrations, posing an additional diagnostic challenge. A 23-year-old woman with decreased muscle strength and hallucinations was diagnosed with 'catatonic depression' and admitted to a residential mental health facility. Read More

Int J Geriatr Psychiatry 2022 Apr 11;37(5). Epub 2022 Apr 11.

Division of Psychiatry, University College London (UCL), London, UK.

Objectives: Although psychiatric disorders have been found to be associated with increased risk of dementia, previous findings are mixed, and the nature of these relationships remains poorly understood. We examined longitudinal associations between depression, anxiety, post-traumatic stress disorders (PTSD), bipolar disorder (BPD), psychotic disorders and subsequent dementia.

Methods: We searched three databases for longitudinal, population-based studies investigating associations between psychiatric disorders and dementia (PROSPERO registration: CRD42020209638). Read More

Neurol Sci 2022 Apr 18. Epub 2022 Apr 18.

U.O. Neurologia, Azienda Ospedaliero Universitaria Di Modena, Modena, Italy.

Introduction: Dementia occurring in young people may be difficult to recognize. We compared the time to diagnosis between young- (YOD, age < 65) and late-onset dementia (LOD).

Methods: Time between the onset of symptoms and the diagnosis was measured in YOD and LOD patients consecutively seen in a cognitive neurology clinic. Read More

World J Psychiatry 2022 Mar 19;12(3):470-482. Epub 2022 Mar 19.

Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.

Background: Mental disorders are common comorbidities among individuals with neurological diseases, and the prevalence of depressive and anxiety-related symptoms in newly referred patients at neurology outpatient clinics is high. There have been few studies on the mental health of patients with late-onset myasthenia gravis (MG).

Aim: To examine the relationship between clinical features and the mental health symptoms within late-onset MG patients. Read More

Front Pharmacol 2022 25;13:826568. Epub 2022 Mar 25.

Research Center for Basic Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.

Folates, provided by food, are commonly used antidepressant synergists in late-onset depression (LOD). However, increased intake of folic acid in the elderly population might lead to the accumulation of unmetabolized folic acid in the systemic circulation, leading to enhanced deterioration of the central nervous system function. In addition, folates cannot access the brain directly because of the blood-brain barrier. Read More

Neurosci Biobehav Rev 2022 06 26;137:104635. Epub 2022 Mar 26.

Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Current first-line treatments for major depressive disorder (MDD), i.e., antidepressant drugs and psychotherapy, show delayed onset of therapeutic effect as late as 2-3 weeks or more. Read More

Front Neurosci 2022 8;16:827447. Epub 2022 Mar 8.

Division of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, NC, United States.

Introduction: Depression is a common, though heterogenous, comorbidity in late-onset Alzheimer's Disease (LOAD) patients. In addition, individuals with depression are at greater risk to develop LOAD. In previous work, we demonstrated shared genetic etiology between depression and LOAD. Read More

J Pers Med 2022 Mar 2;12(3). Epub 2022 Mar 2.

Department of Psychiatry, College of Medicine, Hanyang University, Gyungchun-ro 153, Guri-si 11923, Korea.

Psychosis can include schizophrenia, mood disorders with psychotic features, delusional disorder, active delirium, and neurodegenerative disorders accompanied by various psychotic symptoms. Late-onset psychosis requires careful intervention due to the greater associated risks of secondary psychosis; higher morbidity and mortality rates than early-onset psychosis; and complicated treatment considerations due to the higher incidence of adverse effects, even with the black box warning against antipsychotics. Pharmacological treatment, including antipsychotics, should be carefully initiated with the lowest dosage for short-term efficacy and monitoring of adverse side effects. Read More

J Clin Psychiatry 2022 03 23;83(3). Epub 2022 Mar 23.

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.

The association of treatment resistance with physical and psychiatric comorbidities remains unclear in elderly patients with late-onset major depressive disorder (MDD).

Participants were selected from the Taiwan National Health Insurance Research Database. We included patients aged ≥ 65 years with first-episode MDD ( codes: 296. Read More

EClinicalMedicine 2022 Mar 13;45:101335. Epub 2022 Mar 13.

Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Rd, Yuexiu District, Guangzhou 510080, China.

Background: Identifying independent and interactive associations of a wide range of diseases and multimorbidity and apolipoprotein E4 (APOE4) with dementia may help promote cognitive health. The main aim of the present study was to investigate associations of such diseases and their multimorbidity with incident dementia.

Methods: In this retrospective cohort study, we included 471,485 individuals of European ancestry from the UK Biobank, aged 38-73 years at baseline (2006-10). Read More

Int J Food Sci Nutr 2022 Mar 13:1-8. Epub 2022 Mar 13.

Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, Catania, Italy.

Coffee intake has been recently associated with better cognition and mood in mild vascular cognitive impairment (mVCI). As tobacco can reduce the caffeine half-life, we excluded smokers from the original sample. Hamilton Depression Rating Scale (HDRS), mini-mental state examination (MMSE), Stroop Colour-Word Interference Test (Stroop), activities of daily living (ADL0) and instrumental ADL were the outcome measures. Read More

Front Psychiatry 2022 17;13:836187. Epub 2022 Feb 17.

Unit of Clinical Psychiatry, Department of Neurosciences/DIMSC, School of Medicine and Surgery, Polytechnic University of Marche, Ancona, Italy.

Introduction: Bipolar disorder (BD) onset typically occurs between 15 and 30 years, being diagnosed under the age of 50 in 90% of cases, named "non-late onset BD" (non-LOBD). However, clinical observation of late-onset BD (LOBD) raised some concern regarding a differential psychopathological pattern, outcomes and treatment, including a specific affective temperament vulnerability. Therefore, an exploratory study in the "real world" was carried out by investigating psychopathological and temperamental features of a psychogeriatric cohort of LOBD and non-LOBD subjects. Read More

J Affect Disord 2022 05 25;305:151-158. Epub 2022 Feb 25.

Clinical Physiology, Visas Center, University Hospital, Saint-Etienne, France.; INSERM SAINBIOSE U1059, DVH, Jean Monnet University, Saint Etienne, France.

Introduction: Cross-sectional studies highlighted changes in autonomic nervous system (ANS) activity in geriatric depression. However, few longitudinal studies assessed this link which remains still debated. We examined the longitudinal association between lifetime depression history, current depressive disorders, and the evolution of ANS activity in older community women. Read More

Brain Sci 2022 Feb 16;12(2). Epub 2022 Feb 16.

The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510000, China.

(1) Background: Odor identification (OI) dysfunction is a potential predictor of developing dementia in late life depression (LLD). However, it is not clear whether patients with early onset depression (EOD) and late onset depression (LOD) may exhibit different OI dysfunctions. The aim of this study was to compare OI between EOD patients and LOD patients and its relationship with cognitive function. Read More

Acta Neurol Scand 2022 Jul 20;146(1):24-33. Epub 2022 Feb 20.

Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Objective: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. The proportion of late-onset ALS in China were low and may have distinct clinical and genetic manifestations. We aimed to investigate the natural history and remarkable psychiatric state of ALS with age at onset over 60 years in China. Read More

Front Immunol 2022 4;13:798538. Epub 2022 Feb 4.

Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang, China.

Existing evidence demonstrates that coronavirus disease 2019 (COVID-19) leads to psychiatric illness, despite its main clinical manifestations affecting the respiratory system. People with mental disorders are more susceptible to COVID-19 than individuals without coexisting mental health disorders, with significantly higher rates of severe illness and mortality in this population. The incidence of new psychiatric diagnoses after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is also remarkably high. Read More