23,581 results match your criteria Late-Onset Depression


CD33 in Alzheimer's Disease - Biology, Pathogenesis, and Therapeutics: A Mini-Review.

Authors:
Lingzhi Zhao

Gerontology 2018 Dec 12:1-9. Epub 2018 Dec 12.

Alzheimer's disease (AD) affects nearly 50 million people worldwide, and currently no disease-modifying treatment is available. With continuous failure of anti-amyloid-beta- or tau-based therapies, identification of new targets has become an urgent necessity for AD prevention and therapy. Recently, conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of AD. Read More

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December 2018

Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study.

PLoS One 2018 12;13(12):e0207885. Epub 2018 Dec 12.

Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, United States of America.

Two thirds of all persons with late-onset Alzheimer's disease (AD) are women. Identification of sex-based molecular mechanisms underpinning the female-based prevalence of AD would advance development of therapeutic targets during the prodromal AD phase when prevention or delay in progression is most likely to be effective. This 3-year brain imaging study examines the impact of the menopausal transition on Alzheimer's disease (AD) biomarker changes [brain β-amyloid load via 11C-PiB PET, and neurodegeneration via 18F-FDG PET and structural MRI] and cognitive performance in midlife. Read More

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December 2018

A 10-point plan for avoiding hyaluronic acid dermal filler-related complications during facial aesthetic procedures and algorithms for management.

Clin Cosmet Investig Dermatol 2018 23;11:603-611. Epub 2018 Nov 23.

Institute of Medical and Biomedical Education, St George's University of London, London, UK.

The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful preconsideration of causative factors, categorized as patient, product, and procedure related. Patient-related factors include history, which involves a preprocedural consultation with careful elucidation of skin conditions, systemic disease, medications, and previous cosmetic procedures. Read More

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November 2018
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Microglial cell activation and senescence are characteristic of the pathology FXTAS.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

MIND Institute, UC Davis Medical Center, Sacramento, California, USA.

Background: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene. Expansions of more than 200 CGG repeats give rise to fragile X syndrome, the most common inherited form of cognitive impairment. Fragile X-associated tremor/ataxia syndrome is characterized by cerebellar tremor and ataxia, and the presence of ubiquitin-positive inclusions in neurons and astrocytes. Read More

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December 2018
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Reply to: Response to placental growth factor as an indicator of fetal growth restriction in late-onset small-for-gestational age pregnancies.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E24

Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand.

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December 2018

Response to: Placental growth factor as an indicator of fetal growth restriction in late-onset small-for-gestational age pregnancies.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E23-E24

Brighton and Sussex Medical School, Brighton, UK.

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December 2018

[Acute dystonia in a patient with an elevated clozapine level due to an infection].

Tijdschr Psychiatr 2018 ;60(12):843-847

Acute dystonia is a side-effect associated with the use of antipsychotics. We describe the case of a 75-year-old patient with late-onset schizophrenia who used clozapine. During a hospital admission due to pneumonia, she developed a form of acute dystonia consisting of a rotational torticollis, which disappeared rapidly after treatment with biperiden. Read More

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January 2018
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Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation.

Leuk Res Rep 2019 22;11:5-7. Epub 2018 Nov 22.

Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Wakayama, Japan.

Thyroid dysfunction is an important issue in patients receiving autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, the exact mechanisms underlying thyrotoxicosis secondary to HSCT remain unclear. The present case exhibited a reversed imbalance in helper/suppressor T-cell populations and B-cell dysregulation for a long time after transplantation, and the reactivation of cytomegalovirus may have been associated with the development of clinical hyperthyroidism. Read More

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November 2018

Steroidogenic effects of extract on the levels of steroidogenic enzymes in mouse Leydig cells.

Anim Cells Syst (Seoul) 2018 8;22(6):407-414. Epub 2018 Nov 8.

Department of Urology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

In this study, we investigated the steroidogenic effect of extract on mouse TM3 Leydig cells, which produce male hormones by increasing the levels of steroidogenic enzymes. Steroidogenic enzymes are involved in the production of testosterone in the testis. To date, the steroidogenic effect of has not been reported. Read More

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November 2018

TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism.

Front Aging Neurosci 2018 23;10:395. Epub 2018 Nov 23.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, China.

Alzheimer's disease (AD) is the leading cause of age-related dementia among the elderly population. Recent genetic studies have identified rare variants of the gene encoding the triggering receptor expressed on myeloid cells-2 (TREM2) as significant genetic risk factors in late-onset AD (LOAD). TREM2 is specifically expressed in brain microglia and modulates microglial functions in response to key AD pathologies such as amyloid-β (Aβ) plaques and tau tangles. Read More

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November 2018

A Comparative Study of Early and Late Onset Freezing of Gait in Parkinson's Disease.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):256-262

Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Background: Freezing of gait (FOG) is a common and debilitating symptom in Parkinson's disease (PD); the pathogenesis and natural course of which has not been fully understood.

Objectives: This study was performed to evaluate patients with FOG in PD and ascertain factors contributing to an early onset of FOG in patients with PD.

Methodology: A chart review of 100 patients with PD (FOG [+] 50, FOG [-]: 50) was performed. Read More

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December 2018

MicroRNAs as diagnostic and therapeutic tools for Alzheimer's disease: advances and limitations.

Neural Regen Res 2019 Feb;14(2):242-255

Department of Anatomy, University of Otago, Dunedin, New Zealand.

Alzheimer's disease (AD) is the most common age-related, progressive neurodegenerative disease. It is characterized by memory loss and cognitive decline and responsible for most cases of dementia in the elderly. Late-onset or sporadic AD accounts for > 95% of cases, with age at onset > 65 years. Read More

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February 2019

Next Generation Sequencing Analysis in Early Onset Dementia Patients.

J Alzheimers Dis 2018 Dec 3. Epub 2018 Dec 3.

Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Background: Early onset dementias (EOD) are rare neurodegenerative dementias that present before 65 years. Genetic factors have a substantially higher pathogenetic contribution in EOD patients than in late onset dementia.

Objective: To identify known and/or novel rare variants in major candidate genes associated to EOD by high-throughput sequencing. Read More

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December 2018

Clinical characteristics and genetic variation in atopic dermatitis patients with and without allergic contact dermatitis.

Eur J Dermatol 2018 Oct;28(5):637-643

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

In patients with atopic dermatitis (AD), the risk of contact sensitization may be higher as the disrupted skin barrier may increase the penetration of contact allergens. Therefore, it is necessary to screen for concurrent allergic contact dermatitis (ACD) in AD patients. To identify the clinical characteristics and genetic variation in AD patients with concurrent ACD. Read More

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October 2018

Delayed immune-related adverse events in assessment for dose-limiting toxicity in early phase immunotherapy trials.

Eur J Cancer 2018 Dec 6;107:1-7. Epub 2018 Dec 6.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada; Drug Development Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

Background: Immunotherapy (IO) agents can cause late-onset immune-related adverse events (irAEs). In phase I trials, observation for dose-limiting toxicities (DLTs) is typically limited to the first cycle. The incidence of delayed-onset DLTs and their potential impact on dose determination have not been fully elucidated. Read More

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December 2018

Oxidative stress markers in saliva and plasma differ between diet-controlled and insulin-controlled gestational diabetes mellitus.

Diabetes Res Clin Pract 2018 Dec 6. Epub 2018 Dec 6.

Department of Bioanalysis and Drugs Analysis, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, Poland.

Objectives: The aims of the study were as follows: to investigate possible differences between plasma oxidative status (OS) in late-onset GDM and well-characterized healthy pregnant women (oral health, diet); to verify the existence of possible differences between GDMG1 (diet-treated) and GDMG2 (insulin-treated GDM); to determine whether oxidative stress markers could be detected in saliva.

Material And Methods: A total of 89 pregnant women (n=89; 59 with GDM and 30 controls) were evaluated. Malondialdehyde (MDA), total antioxidant capacity (ORAC), inactivation of aldehyde dehydrogenase (I), activity of glutathione peroxidase (GPx) and glutathione transferase (GST)) in plasma and/or saliva were analyzed. Read More

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December 2018

Genetic variation in TLR pathway and the risk of pulmonary tuberculosis in a Moldavian population.

Infect Genet Evol 2018 Dec 5. Epub 2018 Dec 5.

Hannover Unified Biobank, Hannover Medical School, Hannover, Germany; Department of Human Genetics, Hannover Medical School, Hannover, Germany.

Toll-like receptors (TLRs) play a critical role in initiating an immune response to infections. In this study, we examined whether single nucleotide polymorphisms (SNPs) in TLR pathway genes are associated with pulmonary tuberculosis (PTB) in a Moldavian population. Thirty-four SNPs in genes associated with the TLR pathway and two SNPs in ASAP1 gene identified by GWAS were selected for genotyping in 272 patients and 251 community-matched healthy controls. Read More

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December 2018

Clinical and genetic characteristics of late-onset Huntington's disease.

Parkinsonism Relat Disord 2018 Nov 29. Epub 2018 Nov 29.

Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands; GROW Research Institute for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive.

Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Read More

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November 2018

Long-term follow-up of women with early onset pre-eclampsia shows subclinical impairment of the left ventricular function by two-dimensional speckle tracking echocardiography.

Pregnancy Hypertens 2018 Oct 6;14:9-14. Epub 2018 Jul 6.

Department of Cardiology, Aarhus University Hospital, Skejby, Denmark.

Objectives: This study compares differences in the long-term myocardial function between women with early (EOPE) and late onset preeclampsia (LOPE) and age matched normotensive controls using two-dimensional speckle tracking echocardiography.

Methods: The study population comprised 93 women who gave birth at Department of Gynecology and Obstetrics, Randers Regional Hospital between 1998 and 2008. The women were grouped as EOPE (n = 31), LOPE (n = 22), and women with previous normotensive pregnancies (n = 40). Read More

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October 2018

sFlt-1/PlGF and Doppler ultrasound parameters in SGA pregnancies with confirmed neonatal birth weight below 10th percentile.

Pregnancy Hypertens 2018 Oct 17;14:79-85. Epub 2018 Aug 17.

Department of Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland.

We explored whether there was a relationship between the sFlt-1/PlGF ratio in early-late and late-onset SGA patients and whether it is associated with neonatal birth weight.

Material/methods: 110 patients who were diagnosed with a fetal weight below the 10th percentile for gestational age and who at the same time delivered neonates with a birth weight below the 10th percentile for gestational age. For each of the patients sFlt-1, PlGF and the sFlt-1/PlGF ratio were studied and uterine artery (UtA) and umbilical artery (UA) Doppler were performed. Read More

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October 2018

Reduced methylation downregulates CD39/ENTPD1 and ZDHHC14 to suppress trophoblast cell proliferation and invasion: Implications in preeclampsia.

Pregnancy Hypertens 2018 Oct 24;14:59-67. Epub 2018 Mar 24.

Obstetrics Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China. Electronic address:

Preeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Read More

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October 2018

Serum soluble LIGHT in the early third trimester as a novel biomarker for predicting late-onset preeclampsia.

Pregnancy Hypertens 2018 Oct 13;14:174-176. Epub 2018 Oct 13.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan. Electronic address:

Our aim was to evaluate whether serum levels of soluble LIGHT (sLIGHT) at 27-31 weeks can predict the later occurrence of gestational hypertension (GH), late-onset preeclampsia (PE), and early-onset PE. Mean blood pressure (MBP), soluble fma-like tyrosine kinase 1/placental growth factor (sFlt-1/PlGF) ratio at 27-31 weeks, and sLIGHT at 27-31 weeks were independent risk factors for late-onset PE. The combination of the three risk factors improved sensitivity with a false-positive rate of 10% (MBP: 60%, log(sFlt-1/PlGF): 45%, sLIGHT: 35%, combination: 75%). Read More

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October 2018

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia.

Pregnancy Hypertens 2018 Oct 5;14:115-120. Epub 2018 Sep 5.

Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, 163 Studley Road, Heidelberg 3084, Victoria, Australia. Electronic address:

Introduction: Preeclampsia is a severe complication of pregnancy, and likely arises from abnormal placental development in early pregnancy. Persistent placental hypoxia is thought to trigger the release of anti-angiogenic factors into the maternal circulation leading to widespread endothelial dysfunction. Epidermal growth factor-like domain 7 (EGFL7) is a secreted angiogenic factor that may play a key role in the disrupted angiogenesis seen in response to placental hypoxia that characterizes preeclampsia. Read More

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October 2018

[Ataxia telangiectasia. A prototype of neurological involvement in primary immune deficiencies].

Authors:
Zoltán Liptai

Orv Hetil 2018 Dec;159(49):2057-2064

Szent László Kórház Telephely, Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet Budapest, Albert Flórián út 5-7., 1097.

The number of primary immune deficiencies exceeds 350, approximately a quarter of them having neurological implications. Severe central nervous system infections may occur in an even higher proportion. Beyond listing in a table of all diseases with a neurological impact, the author gives detailed analysis of one typical disorder. Read More

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December 2018

Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri.

Biogerontology 2018 Dec 5. Epub 2018 Dec 5.

Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.

Current studies have generated disputes on the age-related change in the concentration of growth differentiation factor 11 (GDF11) and its role in the genesis of rejuvenation conditions. In this study we showed for the first time that both GDF11 gene expression and its protein abundance decreased with age in the fish Nothobranchius guentheri. We also showed that rGDF11 fed was indeed absorbed by the fish. Read More

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December 2018

Two cases of late-onset neuromyelitis optica spectrum disorder initially presenting with isolated cerebral white matter lesions.

eNeurologicalSci 2018 Dec 19;13:35-37. Epub 2018 Nov 19.

Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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December 2018

The spatial distribution pattern of Connexin26 expression in supporting cells and its role in outer hair cell survival.

Cell Death Dis 2018 Dec 5;9(12):1180. Epub 2018 Dec 5.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.

Mutations in the GJB2 gene (which encodes Connexin26 (Cx26)) account for about a quarter of all cases of non-syndromic deafness. Previous studies have indicated that knockout (KO) of Gjb2 gene during early postnatal days can cause outer hair cell (OHC) loss in mouse models. However, the postnatal spatial distribution pattern of Cx26 in different types of supporting cells (SCs) and the role of such distributions for the survival of OHCs is still obscure. Read More

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December 2018

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β Induced Synaptic Dysfunction and Loss.

J Neurosci 2018 Dec 5. Epub 2018 Dec 5.

Cellular Neuroscience, Neurodegeneration & Repair, Departments of Neurology and of Neuroscience, Yale University School of Medicine, New Haven, CT USA 06536.

Dozens of genes have been implicated in Late Onset Alzheimer's Disease (AD) risk, but none have a defined mechanism of action in neurons. Here, we show that the risk factor Pyk2 (PTK2B) localizes specifically to neurons in adult brain. Absence of Pyk2 has no major effect on synapse formation nor the basal parameters of synaptic transmission in the hippocampal Schaffer collateral pathway. Read More

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December 2018
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Adult With Mutation and Late-Onset Congenital Central Hypoventilation Syndrome.

J Clin Sleep Med 2018 Nov 29. Epub 2018 Nov 29.

Abstract: 20/27 polyalanine repeat mutation (PARM) in patients with congenital central hypoventilation syndrome (CCHS) is generally associated with full-time ventilator dependence, Hirschsprung disease, and increased risk for cardiac asystole. We follow a 14-year-old boy with CCHS 20/27 PARM who is full-time ventilator dependent via tracheostomy and has Hirschsprung disease. His mother, age 52 years, has a history of prolonged recovery from anesthesia and an elevated serum bicarbonate level of 45 mEq/L discovered on routine blood chemistry. Read More

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November 2018

Amisulpride for very late-onset schizophrenia-like psychosis: the ATLAS three-arm RCT.

Health Technol Assess 2018 Nov;22(67):1-62

Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.

Background: Very late-onset (aged ≥ 60 years) schizophrenia-like psychosis (VLOSLP) occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy or risks of antipsychotic treatment. Most patients are not prescribed treatment.

Objectives: The study investigated whether or not low-dose amisulpride is superior to placebo in reducing psychosis symptoms over 12 weeks and if any benefit is maintained by continuing treatment thereafter. Read More

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November 2018
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Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.

Brain Pathol 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurobiology, The University of Chicago, Chicago, IL, USA.

BIN1 is the most significant late-onset Alzheimer's Disease (AD) susceptibility locus identified via genome-wide association studies. BIN1 is an adaptor protein that regulates membrane dynamics in the context of endocytosis and membrane remodeling. An increase in BIN1 expression and changes in the relative levels of alternatively-spliced BIN1 isoforms have been reported in the brains of patients with AD. Read More

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November 2018
4 Reads

A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.

Alzheimers Dement 2018 Nov 29. Epub 2018 Nov 29.

Departments of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA, USA; Departments of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Departments of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Departments of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Departments of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA. Electronic address:

Introduction: The genetic architecture of Alzheimer's disease (AD) is only partially understood.

Methods: We conducted an association study for AD using whole sequence data from 507 genetically enriched AD cases (i.e. Read More

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November 2018

Biliary atresia: 20-40-year follow-up with native liver in an Italian centre.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatric Surgery, "Spedali Civili" Children's Hospital, 25123, Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, 25123, Brescia, Italy.

Introduction: Biliary atresia (BA) represents the leading indication for liver transplantation in childhood. Only few studies reported the outcome of patients who survived more than 20 years on their native liver, and up to date there are no Italian data available. We reported our 40-year single centre experience with long-term follow-up of BA patients. Read More

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November 2018
2 Reads

Serum endocan concentration and its correlation with severity of hypertensive disorders in pregnancy.

J Matern Fetal Neonatal Med 2018 Dec 2:1-7. Epub 2018 Dec 2.

a Department of Perinatology and Gynecology , Poznan University of Medical Sciences , Poznań , Poland.

Introduction: Endocan plays a role in the development of vascular tissue in health and disease and is an indicator of endothelial cells activation and angiogenesis.

Objective: The aim of this study was to investigate the relationship between endocan serum levels and various types of hypertensive disorders in pregnant women.

Patients And Methods: We created three study groups (preeclampsia [n = 60], chronic hypertension [n = 39], gestational hypertension [n = 58]) and the control group consisting of 59 healthy pregnant women. Read More

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December 2018
1 Read

Components of the antepartum, intrapartum, and postpartum exposome impact on distinct short-term adverse neonatal outcomes of premature infants: A prospective cohort study.

PLoS One 2018 5;13(12):e0207298. Epub 2018 Dec 5.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United states of America.

We aimed to test the hypothesis that determinants of the perinatal clinical exposome related to the underlying etiology of premature birth (PTB) impact differently on select neonatal outcomes. We conducted a prospective longitudinal study of 377 singleton preterm neonates [gestational age (GA) at birth: 23-34 weeks] separated into three distinct contemporaneous newborn cohorts: i) spontaneous PTB in the setting of intra-amniotic infection/inflammation (yes-IAI, n = 116); ii) spontaneous PTB in the absence of IAI (no-IAI, n = 130), and iii) iatrogenic PTB for preeclampsia (iPTB-PE, n = 131). Newborns (n = 372) were followed until death or discharge. Read More

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December 2018
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Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations.

PLoS Genet 2018 Dec 5;14(12):e1007791. Epub 2018 Dec 5.

John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.

The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by ε4, however, differs across populations, with populations of African ancestry showing lower ε4 risk compared to those of European or Asian ancestry. The cause of this heterogeneity in risk effect is currently unknown; it may be due to environmental or cultural factors correlated with ancestry, or it may be due to genetic variation local to the ApoE region that differs among populations. Read More

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December 2018
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Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.

Mol Psychiatry 2018 Dec 4. Epub 2018 Dec 4.

Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA.

Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people to cognitively defined subgroups on the basis of relative performance in memory, executive functioning, visuospatial functioning, and language at the time of Alzheimer's disease diagnosis. Read More

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December 2018
6 Reads

Expanding clinical phenotype in CACNA1C related disorders: From neonatal onset severe epileptic encephalopathy to late-onset epilepsy.

Am J Med Genet A 2018 Dec 4. Epub 2018 Dec 4.

Division of Pediatric Neurology, Department of Neurology, University of Washington, Seattle, Washington.

CACNA1C (NM_000719.6) encodes an L-type calcium voltage-gated calcium channel (Ca 1.2), and pathogenic variants have been associated with two distinct clinical entities: Timothy syndrome and Brugada syndrome. Read More

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December 2018
1 Read

The effect of thyroid functions on osteopenia of prematurity in preterm infants.

J Pediatr Endocrinol Metab 2018 Dec 4. Epub 2018 Dec 4.

Division of Neonatology, Zekai Tahir Burak Women's Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Altıntag, Ankara, Turkey.

Background It is known that thyroid hormones have effects on bone development. In particular, the effect of thyroid hormones on osteopenia of prematurity (OOP) has not been examined in preterm infants. Our study aimed to examine the relationship between OOP and congenital hypothyroidism (CH) in preterm infants. Read More

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December 2018
1 Read

Population Pharmacokinetics and Dosing Optimization of Amoxicillin in Neonates and Young Infants.

Antimicrob Agents Chemother 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Shandong University, Jinan 250014, China

Amoxicillin is widely used to treat bacterial infections in neonates. However, considerable inter-center variability in dosage regimens of antibiotic exist in clinical practice. Pharmacokinetics of amoxicillin has been described in only a few preterm neonates. Read More

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December 2018
10 Reads

Efficacy of levetiracetam compared with phenytoin in prevention of seizures in brain injured patients: A meta-analysis.

Medicine (Baltimore) 2018 Nov;97(48):e13247

Department of Neurosurgery, the Second Hospital of Hebei Medical University.

Background: Early and/or late onset in patients with brain injury (BI) is associated with a poorer prognosis, and phenytoin (PHT) is standard of care to prevent seizures. Levetiracetam (LEV), an alternative antiepileptic drug, is associated with less cognitive disruption. The purpose of this study was to evaluate the safety and efficacy of LEV in the prevention of brain traumatic seizures with the standard drug PHT. Read More

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November 2018

Long-term outcomes of a patient with late-onset multiple acyl-CoA dehydrogenase deficiency caused by novel mutations in ETFDH: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13153

Affiliated Hospital of the Institute of Neurology, Anhui University of Chinese Medicine, Hefei, China.

Rationale: Late-onset multiple acyl-coenzyme A dehydrogenase deficiency (MADD) mainly affects the neck extensor muscle group, which has been confirmed by novel mutations in electron-transferring-flavoprotein dehydrogenase (ETFDH). So far, a few cases have been reported with long-term follow-up. Here we report a case of late-onset MADD where the patient was followed up for 8 years during which time he underwent 2 muscle biopsies and 2 pathological examinations and his symptoms were significantly alleviated after appropriate treatments. Read More

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November 2018

Neurodevelopmental outcomes of extremely preterm infants in New South Wales and the Australian Capital Territory.

J Paediatr Child Health 2018 Nov 30. Epub 2018 Nov 30.

Department of Newborn Care, Royal Hospital for Women, Sydney, New South Wales, Australia.

Aim: This study aimed to provide updated information on gestation-specific neurodevelopmental outcomes of extremely to very preterm infants 23-28 weeks' gestation admitted to neonatal intensive care units (NICUs).

Methods: This was a population-based retrospective cohort study of infants born between 23 and 28 weeks' gestation and admitted to a network of NICUs between 2007 and 2012 in a well-defined geographic area of New South Wales (NSW) and the Australian Capital Territory (ACT). Primary outcome was moderate to severe neurodevelopmental impairment. Read More

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November 2018
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Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014-15: a prospective surveillance study.

Lancet Infect Dis 2018 Nov 26. Epub 2018 Nov 26.

Paediatric Infectious Diseases Research Group & Vaccine Institute, St George's University of London and St George's University Hospitals NHS Trust, London, UK.

Background: Group B streptococcus is a leading cause of serious infection in young infants in many countries worldwide. We aimed to define the burden and clinical features of invasive group B streptococcal disease in infants younger than 90 days in the UK and Ireland, together with the characteristics of disease-causing isolates.

Methods: Prospective, active national surveillance of invasive group B streptococcal disease in infants younger than 90 days was done from April 1, 2014, to April 30, 2015, through the British Paediatric Surveillance Unit, microbiology reference laboratories, and national public health agencies in the UK and Ireland. Read More

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November 2018
1 Read

In vivo induction of membrane damage by β-amyloid peptide oligomers.

Acta Neuropathol Commun 2018 Nov 29;6(1):131. Epub 2018 Nov 29.

Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO, USA.

Exposure to the β-amyloid peptide (Aβ) is toxic to neurons and other cell types, but the mechanism(s) involved are still unresolved. Synthetic Aβ oligomers can induce ion-permeable pores in synthetic membranes, but whether this ability to damage membranes plays a role in the ability of Aβ oligomers to induce tau hyperphosphorylation, or other disease-relevant pathological changes, is unclear. To examine the cellular responses to Aβ exposure independent of possible receptor interactions, we have developed an in vivo C. Read More

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November 2018
3 Reads

Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis.

Malar J 2018 Nov 29;17(1):443. Epub 2018 Nov 29.

University Hospital Institute for Infectious and Tropical Diseases, Aix-Marseille University, Marseille, France.

Background: Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature review to elucidate key attributes of malaria in this group with a focus on possible areas of acquisition of malaria and treatment challenges.

Results: A total of 146 cases were identified from the GeoSentinel database from 1999 through September 2017, with a marked increase in 2014 and 2015. Read More

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November 2018

Late onset Allergic Broncho-Pulmonary Aspergillosis (ABPA).

QJM 2018 Nov 28. Epub 2018 Nov 28.

Department of Respiratory Medicine, Tallaght Hospital.

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November 2018
1 Read

[Secondary osteoporosis. Late-onset hypogonadisim in the aging male.]

Authors:
Sumito Ogawa

Clin Calcium 2018 ;28(12):1641-1646

Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Late-onset hypogonadism(LOH)in aging male is known to represent disorder of bone metabolism, contributing to the development of secondary osteoporosis. And recent findings suggest that it is also associated with sarcopenia and frailty. Diagnosis and therapeutic approaches against LOH in aging male might be crucial not only for improving clinical symptoms of LOH but also for maintaining bone mineral density and prevention from male osteoporosis. Read More

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January 2018

Origin of sporadic late-onset hereditary ATTR Val30Met amyloidosis in Japan.

Amyloid 2018 Sep;25(3):143-147

a Department of Neurology, Graduate School of Medical Sciences , Kumamoto University , Kumamoto , Japan.

Hereditary transthyretin (ATTRm) amyloidosis, formerly known as familial amyloid polyneuropathy, is a major type of hereditary systemic amyloidosis, in which the disease is caused by mutant transthyretin (TTR). Although more than 140 different point mutations have been identified in the TTR gene, ATTRm amyloidosis patients with the TTR Val30Met mutation are most frequently found worldwide. Interestingly, the onset age of the ATTR Val30Met amyloidosis is highly varied among countries and regions. Read More

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September 2018
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The Impact of Late Onset Arterial Hypotension on Respiratory Outcome in Extremely Premature Infants.

Neonatology 2018 Nov 28;115(2):164-168. Epub 2018 Nov 28.

Background: In extremely premature infants, arterial hypotension in the first days after birth has been associated with an increased risk for bronchopulmonary dysplasia (BPD). Some infants present with hypotension at a later postnatal age, but the relationship between late onset hypotension (LOH) and BPD has not been evaluated.

Objective: To evaluate the association between LOH and BPD and to identify pre- and postnatal factors associated with LOH. Read More

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November 2018