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Turk Psikiyatri Derg 2019 ;30(4):290-294

Normal pressure hydrocephalus (NPH), typically associated with the triad of gait disturbance, dementia and urinary incontinence, rarely presents with symptoms of mania, depression or psychosis and psychiatric disorders may complicate the diagnosis. Few cases of NPH and psychiatric disease comorbidity have been reported so far. In most of these cases, NPH was associated with depression and psychotic symptoms. Read More

Neurology 2020 Jun 24. Epub 2020 Jun 24.

From the Departments of Neurology (A.R., E.S., I.D., H.H., S.J., H.J., A.L., H.S., S.P., R.S.I., L.M.) and Radiology (J.D., M.J.d.L., L.M.), Weill Cornell Medical College; Division of Biostatistics and Epidemiology (K.H., I.D.), Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY; ADM Diagnostics (R.A., D.M.), Chicago, IL; and Departments of Pharmacology and Neurology (R.D.B.), College of Medicine, University of Arizona, Tucson.

Objective: To investigate sex differences in late-onset Alzheimer disease (AD) risks by means of multimodality brain biomarkers (β-amyloid load via C-Pittsburgh compound B [PiB] PET, neurodegeneration via F-fluorodeoxyglucose [FDG] PET and structural MRI).

Methods: We examined 121 cognitively normal participants (85 women and 36 men) 40 to 65 years of age with clinical, laboratory, neuropsychological, lifestyle, MRI, FDG- and PiB-PET examinations. Several clinical (e. Read More

J Affect Disord 2020 Jul 1;272:409-416. Epub 2020 May 1.

Laboratorio de Neurociencias LIM27, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil.

Background: Cognitive impairment is a common feature of late-life depression (LLD). Early studies using Alzheimer's disease (AD) biomarkers inferred a biological link between AD pathology and LLD, but recent findings have challenged this association. The aim of this investigation was to determine a panel of AD-related cerebrospinal fluid (CSF) biomarkers in a cross-section of elders with mild cognitive impairment (MCI) with and without LLD. Read More

J Geriatr Psychiatry Neurol 2020 Jun 17:891988720933355. Epub 2020 Jun 17.

Center for Alzheimer's Disease and Related Disorders, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: To compare the quality of life, burden, and depressive symptoms of caregivers of individuals with young-onset dementia (YOD) and late-onset dementia (LOD).

Methods: Using a cross-sectional design, a convenience sample of 110 dyads of individuals with dementia and their caregivers, all living in the community, was included. The care recipients completed assessments about cognition, quality of life, and awareness of disease. Read More

Neurol Sci 2020 Jun 11. Epub 2020 Jun 11.

Department of Neurology, Centro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal.

Introduction: The vermiform appendix is a potential site of initiation of Parkinson's disease (PD) pathology. We hypothesized that the appendectomy earlier in life may alter the clinical expression of PD.

Objective: To explore the effects of appendectomy prior to onset of PD motor symptoms on patients' symptoms, in particular on cognitive dysfunction. Read More

PLoS One 2020 10;15(6):e0234514. Epub 2020 Jun 10.

Department of Geriatric medicine, All India Institute of Medical Science, New Delhi, India.

Background: Mild Behavioural Impairment (MBI), an "at risk" state for incident cognitive declin, is characterized by late onset, sustained neuropsychiatric symptoms of any severity which cannot be accounted for by other formal medical and psychiatric nosology. There is no study related to MBI from India.

Methods And Findings: In this cross-sectional observational study 124 subjects 60 years and above were recruited between March 2017 to October 2018, from memory clinic of department of Geriatric medicine with memory or behavioural complains. Read More

J Asthma 2020 Jun 16:1-9. Epub 2020 Jun 16.

Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Asthma, a major cause of disability and reduced quality of life, has a high global prevalence and burden of death. Despite the propitious guidelines, a substantial portion of asthmatics reportedly have poorly controlled disease. In the current study, we have examined risk factors for uncontrolled asthma in specialty clinics and its association with impaired quality of life. Read More

Psychiatry Res 2020 May 21;290:113051. Epub 2020 May 21.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; South London and Maudsley NHS Foundation Trust, London, UK.

Differences in cognitive function have been suggested in people with late-life depression between those with early- (EOD) and late-onset (LOD), possibly reflecting different etiologies. The cutoff point for EOD and LOD was the first depressive episode before age 60 or later. However, depressive symptoms at the time of disorder are important confounders. Read More

J Neuroradiol 2020 May 12. Epub 2020 May 12.

Institut du Cerveau et de la Moelle épinière, ICM, Inserm, U 1127, CNRS, UMR 7225, Sorbonne Université, 75013 Paris, France; Inria, Aramis-project team, Paris, France; Department of Neuroradiology, AP-HP, Hôpital de la Pitié-Salpêtrière, 75013 Paris, France; Department of Neurology, AP-HP, Hôpital de la Pitié-Salpêtrière, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), 75013 Paris, France. Electronic address:

Background And Purpose: Many artificial intelligence tools are currently being developed to assist diagnosis of dementia from magnetic resonance imaging (MRI). However, these tools have so far been difficult to integrate in the clinical routine workflow. In this work, we propose a new simple way to use them and assess their utility for improving diagnostic accuracy. Read More

Transl Neurodegener 2020 May 12;9(1):18. Epub 2020 May 12.

Department of Neurology and Institute of Neurology, Rui-jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: Neuropsychiatric symptoms (NPS) such as depression, anxiety, apathy, and irritability occur in prodromal phases of clinical Alzheimer's disease (AD), which might be an increased risk for later developing AD. Here we treated young APP/PS1 AD model mice prophylactically with serotonin-selective re-uptake inhibitor (SSRI) paroxetine and investigated the protective role of anti-depressant agent in emotional abnormalities and cognitive defects during disease progress.

Methods: To investigate the protective role of paroxetine in emotional abnormalities and cognitive defects during disease progress, we performed emotional behaviors of 3 months old APP/PS1 mouse following oral administration of paroxetine prophylactically starting at 1 month of age. Read More

J Clin Med 2020 May 2;9(5). Epub 2020 May 2.

Center of Depression, Stress and Sleep Disorders, Psychiatric Clinics (UPK), University of Basel, 4002 Basel, Switzerland.

Background: Compared to the adult onset of multiple sclerosis (AOMS), both early-onset (EOMS) and late-onset (LOMS) are much less frequent, but are often under- or misdiagnosed. The aims of the present study were: 1. To compare demographic and clinical features of individuals with EOMS, AOMS and LOMS, and 2. Read More

Dement Geriatr Cogn Disord 2020 Apr 14:1-13. Epub 2020 Apr 14.

Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom,

Background: Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia, is now gradually gaining in interest. We aimed to conduct a selective review to examine the prevalence rate of NPS in MCI and associations of NPS symptoms with disease progression. Read More

J Obstet Gynaecol Res 2020 Jul 12;46(7):1055-1066. Epub 2020 Apr 12.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Aim: To compare early-onset pre-eclampsia (EOPE) and late-onset pre-eclampsia (LOPE) and provide insight into the pathophysiology of pre-eclampsia (PE).

Methods: Our recent work compared the transcriptomics in decidua of EOPE, LOPE and normal pregnancies (NP).

Results: We found there are a significant number of genes uniquely expressed in the decidua of EOPE and LOPE comparing with NP. Read More

Front Neurosci 2020 26;14:265. Epub 2020 Mar 26.

Nash Family Department of Neuroscience, Friedman Brain Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Late-onset Parkinson's disease (PD) is dominated clinically and experimentally by a focus on dopamine neuron degeneration and ensuing motor system abnormalities. There are, additionally, a number of non-motor symptoms - including cognitive and psychiatric - that can appear much earlier in the course of the disease and also significantly impair quality of life. The neurobiology of such cognitive and psychiatric non-motor symptoms is poorly understood. Read More

CNS Neurosci Ther 2020 Apr 3. Epub 2020 Apr 3.

Department of Neurology, School of Medicine, Affiliated ZhongDa Hospital, Southeast University, Nanjing, China.

Aims: Both amnestic mild cognitive impairment (aMCI) and remitted late-onset depression (rLOD) confer a high risk of developing Alzheimer's disease (AD). This study aims to determine whether the Characterizing AD Risk Events (CARE) index model can effectively predict conversion in individuals at high risk for AD development either in an independent aMCI population or in an rLOD population.

Methods: The CARE index model was constructed based on the event-based probabilistic framework fusion of AD biomarkers to differentiate individuals progressing to AD from cognitively stable individuals in the aMCI population (27 stable subjects, 6 progressive subjects) and rLOD population (29 stable subjects, 10 progressive subjects) during the follow-up period. Read More

Front Pharmacol 2020 13;11:279. Epub 2020 Mar 13.

University of Basel, Universitäre Psychiatrische Kliniken (UPK), Basel, Switzerland.

Late-life depression is associated with significant cognitive impairment. Meta-analyses showed that depression is associated with an increased risk for Alzheimer's disease (AD) and it might be an etiological factor for AD. Since late-life depression is often connected with cognitive impairment and dementia is usually associated with depressive symptoms, a simple diagnostic approach to distinguish between the disorders is challenging. Read More

BMJ Case Rep 2020 Mar 17;13(3). Epub 2020 Mar 17.

Department of Psychiatry, SUNY at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.

Glioblastoma multiforme (GBM) is the most common of the aggressive primary brain tumours arising in adults and has a dire prognosis. Neuropsychiatric symptoms can vary significantly among afflicted persons; psychiatric disturbances may be the predominant presenting symptoms. Distinguishing between functional psychiatric disorders, particularly depression, from other subtle neuropsychiatric disturbances that may accompany GBM can be challenging. Read More

Chest 2020 Mar 12. Epub 2020 Mar 12.

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada; School of Public Health, University of Alberta, Edmonton, AB, Canada. Electronic address:

Background: Early-life stress is becoming an important determinant of immune system programming. Maternal prenatal distress is found to be associated with atopic disease in offspring but the separate effects of postnatal distress are not well-studied.

Research Question: Does the likelihood of asthma and atopic dermatitis in children increase when they are exposed to maternal distress pre- and postnatally in a sex-specific manner?

Study Design And Methods: Using data from a provincial newborn screen and health-care database for 12,587 children born in 2004, maternal distress (depression or anxiety) was defined as prenatal, self-limiting, recurrent, or late-onset postpartum. Read More

Transl Psychiatry 2020 Mar 9;10(1):88. Epub 2020 Mar 9.

Division of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, NC, USA.

Patients with late-onset Alzheimer's disease (LOAD) frequently manifest comorbid neuropsychiatric symptoms with depression and anxiety being most frequent, and individuals with major depressive disorder (MDD) have an increased prevalence of LOAD. This suggests shared etiologies and intersecting pathways between LOAD and MDD. We performed pleiotropy analyses using LOAD and MDD GWAS data sets from the International Genomics of Alzheimer's Project (IGAP) and the Psychiatric Genomics Consortium (PGC), respectively. Read More

JAMA Neurol 2020 Mar 9. Epub 2020 Mar 9.

Global Brain Health Institute, University of California, San Francisco.

Importance: The incidence of unprovoked seizures and epilepsy increases considerably in late life, with approximately one-third of seizures being of unknown etiology. While individuals with dementia have a high risk of developing unprovoked seizures, it is unknown whether older adults with late-onset unprovoked seizures of unknown etiology (LOSU) are at risk of developing dementia.

Objective: To determine whether incident LOSU is associated with a higher risk of dementia among older US veterans. Read More

Biomed Res Int 2020 29;2020:1704879. Epub 2020 Jan 29.

National Yang-Ming University, School of Medicine, Taipei, Taiwan.

Background: Late onset depression (LOD) often occurs in the context of vascular disease and may be associated with risk of dementia. Aspirin is widely used to reduce the risk of cardiovascular disease and stroke. However, its role in patients with LOD and risk of dementia remains inconclusive. Read More

Front Psychiatry 2019 31;10:1024. Epub 2020 Jan 31.

Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: Late-life depression (LLD) has negative impacts on somatic, emotional and cognitive domains of the lives of patients. Elucidating the abnormality in the brain networks of LLD patients could help to strengthen the understanding of LLD pathophysiology, however, the studies exploring the spontaneous brain activity in LLD during the resting state remain limited. This study aimed at identifying the voxel-level whole-brain functional connectivity changes in LLD patients. Read More

J Gerontol A Biol Sci Med Sci 2020 Feb 21. Epub 2020 Feb 21.

Rush Institute for Healthy Aging.

Background: Depression is common in older adults and more prevalent in those with cognitive impairment, vascular risk factors, or stroke. Non-pharmacologic strategies to reduce depression, such as diet, may be effective; however, few studies have investigated the relation.

Methods: A total of 709 participants (23. Read More

Curr Alzheimer Res 2020 ;17(1):16-28

Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.

The majority of research works to date suggest that Major Depressive Disorder (MDD) is a risk factor for dementia and may predispose to cognitive decline in both early and late onset variants. The presence of depression may not, however, reflect the cause, rather, an effect: it may be a response to cognitive impairment or alters the threshold at which cognitive impairment might manifest or be detected. An alternative hypothesis is that depression may be part of a prodrome to Alzheimer's Disease (AD), suggesting a neurobiological association rather than one of psychological response alone. Read More

J Geriatr Psychiatry Neurol 2020 Feb 10:891988720901783. Epub 2020 Feb 10.

GGZ inGeest Specialized Mental Health Care, Amsterdam, the Netherlands.

Objective: Apathy symptoms are defined as a lack of interest and motivation. Patients with late-life depression (LLD) also suffer from lack of interest and motivation and previous studies have linked apathy to vascular white matter hyperintensities (WMH) of the brain in depressed and nondepressed patients. The aim of this study was to investigate the relationship between apathy symptoms, depressive symptoms, and WMH in LLD. Read More

Mol Biol Res Commun 2019 Sep;8(3):135-140

Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India.

The objective of the study was to analyze the frequency of allele in elderly patients with Alzheimer's or vascular dementia or depression; compare these to age/sex matched controls; compare the results with established literature and highlight new findings. A single center, multiple disease, case-control study was performed with three case groups- probable AD patients (n=36), vascular dementia patients (n=29) and depression patients (n=20) and with a control group (n=32). genotyping was performed in whole blood samples collected from patients and controls by restriction isotyping using the enzymes AflIII and HaeII. Read More

Behav Brain Res 2020 Apr 24;383:112487. Epub 2020 Jan 24.

Drug Research and Development Center, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Despite recent advances, current antidepressants have considerable limitations: late onset of action and the high profile of refractoriness. Biomedical research with natural products has gained growing interest in the last years, and had provide useful candidates for new antidepressants. Riparins are a group of natural alkamides obtained from Aniba riparia, which had marked neuroactive effects, mainly as antidepressant and antinociceptive agents. Read More

Mol Psychiatry 2020 Jan 20. Epub 2020 Jan 20.

Child and Adolescent Psychiatry Section, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.

There is growing appreciation that a developmental perspective is helpful in Psychiatry. However, clinical practice and research, especially in an era of very large sample sizes, often ignore the developmental context. In this perspective piece, we discuss why a developmental view is important in Psychiatry and how recent genetic-epidemiological findings further highlight this. Read More

Mov Disord 2020 Apr 17;35(4):679-686. Epub 2020 Jan 17.

Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Background: Biallelic mutations in the MYORG gene were first identified as the cause of recessively inherited primary familial brain calcification. Interestingly, some heterozygous carriers also exhibited brain calcifications.

Objectives: To further investigate the role of single heterozygous MYORG mutations in the development of brain calcifications. Read More

J Psychiatr Res 2020 Mar 3;122:79-87. Epub 2020 Jan 3.

Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta, Instituto de Neurociencias FLENI-CONICET, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; Departamento de Física, Facultad de Cs. Exactas y Naturales, Universidad de Buenos Aires, Argentina.

Tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset Alzheimer's disease (LOAD). There is a need to ascertain methods for the detection of early LOAD features to help with disease prevention efforts. The microstructure of these tracts and anatomical brain connectivity can be assessed by analyzing diffusion MRI (dMRI) data. Read More

Can J Neurol Sci 2020 May;47(3):320-327

Department of Psychology, University of Saskatchewan, Saskatoon, Canada.

Background: Young-onset dementia (YOD) is defined as the onset of dementia symptoms before the age of 65 years and accounts for 2-8% of dementia. YOD patients and their caregivers face unique challenges in diagnosis and management. We aimed to compare the characteristics of rural YOD and late-onset dementia (LOD) patients at a rural and remote memory clinic in Western Canada. Read More

BMC Psychiatry 2019 12 27;19(1):423. Epub 2019 Dec 27.

Department of Psychiatry and Psychotherapy, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, 50931, Cologne, Germany.

Background: Late-life depression (LLD) is one of the most prevalent mental disorders in old age. It is associated with various adverse outcomes and frequent use of health care services thereby remaining a serious public health concern. Compared with depression in early adulthood, most treatment options of LLD are less effective. Read More

Biochem Pharmacol 2020 Apr 25;174:113783. Epub 2019 Dec 25.

Otto-Loewi Research Center for Vascular Biology, Immunology and Inflammation, Division of Pharmacology, Medical University Graz, Universitätsplatz 4, 8010 Graz, Austria. Electronic address:

Neuroinflammation plays a prominent role in the onset of demyelinating diseases, major depressive disorder and delayed neurodegeneration. An open question remains whether pharmacological suppression of inflammation can effectively reduce the progression of these states. Bioactive lipid mediators such as N-acylethanolamines (NAEs) have an anti-inflammatory activity and are of pharmacological interest due to their endogenous on-demand production and the existence of distinct biological targets in humans and animals. Read More

Health Psychol 2020 Apr 19;39(4):307-315. Epub 2019 Dec 19.

School of Psychological Science.

Objective: A single rare disorder or disease (RD) affects fewer than 200,000 Americans. Combined, RDs affect 30 million Americans. Collectively, people with RDs have higher levels of anxiety and depression compared with those with prevalent diseases. Read More

Medicine (Baltimore) 2019 Dec;98(50):e18405

Department of Geriatric Neurology, Qilu Hospital, Shandong University, Jinan.

Alzheimer disease (AD) is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly. Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors for AD patients. Sleep disorder is one closely-related psychiatric symptom of AD. Read More

Diabetes Metab J 2020 Feb 12;44(1):113-124. Epub 2019 Nov 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.

Background: Diabetes mellitus is associated with an increased risk of dementia. We aimed to comprehensively analyze the incidence and risk factors for dementia and young-onset dementia (YOD) in diabetic patients in Korea using the National Health Insurance Service data.

Methods: Between January 1, 2009 and December 31, 2012, a total of 1,917,702 participants with diabetes were included and followed until the date of dementia diagnosis or until December 31, 2015. Read More

Environ Int 2020 Jan 21;134:105325. Epub 2019 Nov 21.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Institute for Exposomics Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Postpartum depression (PPD), which affects up to 1 in 5 mothers globally, negatively impacts the health of both mothers and children. Exposure to ambient air pollution has been linked to depressive symptoms in animal models and human studies, but the relationship between air pollution and PPD has not been widely studied.

Methods: In a birth cohort in Mexico City (509 mothers with available data), we examined the association between exposure to particulate matter ≤2. Read More

Int Rev Neurobiol 2019 26;147:155-188. Epub 2019 Jun 26.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong. Electronic address:

Health Qigong, especially the Eight-Section Brocades (or Baduanjin), has been well established as an effective adjunct intervention to alleviate depressive symptoms of older adults. The easy to learn and safe format of health Qigong allows the promotion and employment by health care professionals to improve the physical and psychosocial wellness of older adults. The cultural relevance of Qigong practice enhances its popularity as a health maintenance practice in Chinese community. Read More

East Asian Arch Psychiatry 2019 Sep;29(3):81-86

Department of Psychiatry, Kowloon Hospital, Hong Kong.

Objective: This study aimed to examine the association between five personality traits and late-onset depression in Hong Kong older people.

Methods: This cross-sectional study included a convenience sample of 40 older people with late-onset depression (LOD) and 54 non-depressed elderly controls. The patients were assessed using the NEO Five Factor Inventory (for personality), the Hamilton Depression Rating Scale (for depression severity), the Mini-Mental State Examination (for cognitive function), the Lawton Instrumental Activities of Daily Living (for functioning), and the Cumulative Illness Rating Scale (for number of physical illnesses). Read More

Neural Regen Res 2020 Jan;15(1):41-46

Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO, USA.

Given the failure to develop disease-modifying therapies for Alzheimer's disease (AD), strategies aiming at preventing or delaying the onset of the disease are being prioritized. While the debate regarding whether depression is an etiological risk factor or a prodrome of AD rages on, a key determining factor may be the timing of depression onset in older adults. There is increasing evidence that untreated early-onset depression is a risk factor and that late-onset depression may be a catalyst of cognitive decline. Read More

Neuroreport 2019 11;30(16):1074-1080

Departments of Psychiatry.

Objective: We previously showed differences in brain grey matter volume changes between patients with early-onset adult depression (EOD) and late-onset adult depression (LOD). Here, we aim to identify whether cortical thickness (CT) is affected by the age of onset in patients with depression.

Methods: High-resolution MRI images were obtained for 54 major depressive disorder (MDD) patients with EOD, 58 patients with LOD, 57 young healthy controls (HCs), and 58 aged HCs. Read More

Ind Psychiatry J 2018 Jul-Dec;27(2):305-307

Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Depression associated with cerebrovascular disease (CVD) is common among the elderly. Two major types are described, including poststroke depression (PSD), which occurs following a clinically apparent stroke and vascular depression (VaD) which results from silent cerebral infarctions or lacunar infarcts mainly in the subcortical regions. Although PSD and VaD have been regarded as distinctive types of depression, there appears to be a great degree of overlap between them. Read More

Asian J Psychiatr 2019 Aug 24;44:108-109. Epub 2019 Jul 24.

Substance Abuse and Mental Health Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Hum Mol Genet 2019 11;28(R2):R219-R225

Centre for Clinical Brain Science, Edinburgh University, Edinburgh, UK.

Over 130 brain diseases are caused by mutations that disrupt genes encoding the proteome of excitatory synapses. These include neurological and psychiatric disorders with early and late onset such as autism, schizophrenia and depression and many other rarer conditions. The proteome of synapses is highly complex with over 1000 conserved proteins which are differentially expressed generating a vast, potentially unlimited, number of synapse types. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(5):141-147

Serbsky National Medical Research Centre for Psychiatry and Narcology, Moscow, Russia; Moscow Research and Clinical Center for Neuropsychiatry, Healthcare Department of Moscow, Moscow, Russia.

Aim: To study structural correlates of apathy in patients with late-life depression.

Material And Methods: Thirty-five patients (≥60 y.o. Read More

Clin Neurol Neurosurg 2019 Sep 4;184:105400. Epub 2019 Jul 4.

Department of Neurology and Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

We present a case of megalencephalic leukoencephalopathy with subcortical cysts without macrocephaly and who initially presented with severe psychiatric symptoms. The patient presented with presented with late-onset secondary generalized focal motor seizures, gait ataxia and mild spasticity with hyperreflexia. MRI showed diffuse white matter hyperintensities and bilateral anterotemporal cysts. Read More

J Affect Disord 2019 10 5;257:257-262. Epub 2019 Jul 5.

Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.

Background: Late-life depression is a great burden of public health. Previous studies reported that physical activity is associated with reduced depressive symptoms among older adults, while the competing nature of physical activity and sedentary behaviors has been largely neglected in studies. We aimed to examine the associations of replacing sedentary behaviors with walking/bicycling or moderate-to-vigorous physical activity (MVPA) with depressive symptoms in older adults. Read More

Zhonghua Nei Ke Za Zhi 2019 Jul;58(7):501-507

Department of Neurology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.

To evaluate the clinical manifestations, metal metabolism, imaging characteristics and treatment response in patients with delayed Wilson disease (WD). Patients with untreated WD (40 with delayed onset and 40 with non-delayed onset) were enrolled. Twenty healthy people were included as normal controls. Read More