1,614 results match your criteria Late Effects of Childhood Cancer and Treatment


Clinico-radiologic features of pleuroparenchymal fibroelastosis in children.

Pediatr Radiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatric Radiology, Texas Children's Hospital, 6701 Fannin St., Houston, TX, 77030, USA.

Background: Pleuroparenchymal fibroelastosis (PPFE) may be underdiagnosed clinically and radiographically in children with a remote history of cancer, leading to a delay in care and unnecessary lung biopsies.

Objective: To describe the characteristic clinical and radiologic findings of PPFE in a cohort of children to facilitate recognition and noninvasive diagnosis.

Materials And Methods: Clinical presentation, history of chemotherapy or radiation therapy, lung or bone marrow transplantation, and lung function testing and outcome were retrospectively extracted from the electronic medical records of eight children treated at our institution's pulmonary medicine clinic with histopathology confirmation of PPFE from 2008 to 2018. Read More

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http://link.springer.com/10.1007/s00247-019-04405-5
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http://dx.doi.org/10.1007/s00247-019-04405-5DOI Listing
April 2019
2 Reads

Limited evidence of non-response bias despite modest response rate in a nationwide survey of long-term cancer survivors-results from the NOR-CAYACS study.

J Cancer Surviv 2019 Apr 16. Epub 2019 Apr 16.

National Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital, Radiumhospitalet, PO 4953, Nydalen, NO-0424, Oslo, Norway.

Purpose: Declining response rates threaten the generalizability of health surveys. We investigate (1) the effect of item order on response rate; (2) characteristics of early , late and non-responders; and (3) potential non-response bias in a population-based health survey of childhood, adolescent and young adult cancer survivors (CAYACS).

Methods: We mailed a questionnaire survey to 5361 eligible CAYACS identified by the Cancer Registry of Norway (CRN), representing a range of cancer diagnoses. Read More

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http://dx.doi.org/10.1007/s11764-019-00757-xDOI Listing

Hepatic late adverse effects after antineoplastic treatment for childhood cancer.

Cochrane Database Syst Rev 2019 Apr 15;4:CD008205. Epub 2019 Apr 15.

Department of Paediatric Oncology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, PO Box 22660, Amsterdam, Netherlands, 1100 DD.

Background: Survival rates have greatly improved as a result of more effective treatments for childhood cancer. Unfortunately, the improved prognosis has been accompanied by the occurrence of late, treatment-related complications. Liver complications are common during and soon after treatment for childhood cancer. Read More

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http://doi.wiley.com/10.1002/14651858.CD008205.pub3
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http://dx.doi.org/10.1002/14651858.CD008205.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463806PMC
April 2019
3 Reads

Late effects after childhood brain tumour treatment: It's not just about the radiation.

Neuro Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network.

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http://dx.doi.org/10.1093/neuonc/noz054DOI Listing

A cross-sectional follow-up study of physical morbidities, neurocognitive function, and attention problems in post-treatment childhood acute lymphoblastic leukemia survivors.

Kaohsiung J Med Sci 2019 Mar 26. Epub 2019 Mar 26.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University and Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. While ALL therapies are highly effective, western studies have shown excesses late life effects of therapies in survivors. In this survey, we recruited subjects being diagnosed as ALL before the age of 18-year-old and had been in complete continuous remission for at least 3 years. Read More

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http://dx.doi.org/10.1002/kjm2.12061DOI Listing
March 2019
1 Read

Combining peptide TNIIIA2 with all- retinoic acid accelerates N-Myc protein degradation and neuronal differentiation in MYCN-amplified neuroblastoma cells.

Am J Cancer Res 2019 1;9(2):434-448. Epub 2019 Feb 1.

Department of Molecular Patho-Physiology, Faculty of Pharmaceutical Sciences, Tokyo University of Science Noda, Chiba, Japan.

Neuroblastoma is one of the common solid tumors of childhood. Nearly half of neuroblastoma patients are classified into the high-risk group, and their 5-year event-free survival (EFS) rates remain unsatisfactory in the range of 30-40%. High-risk neuroblastoma is characterized by amplification of the MYCN gene and excessive expression of its protein product, N-Myc. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405964PMC
February 2019
4 Reads

Late adverse effects related to treatment in a cohort of survivors of childhood and adolescent cancer.

Medicine (Baltimore) 2019 Mar;98(12):e14921

Pharmaceutical Sciences Master Course, University of Sorocaba, UNISO, São Paulo, Brazil.

Taking into consideration the progress in cancer treatment, an increase in the number of adult survivors of childhood cancer is expected. These survivors will have received treatment that predisposes them to late morbidity and increased risk of early mortality. The aim of this single-center retrospective cohort study was to describe the frequency and identify risk factors associated with late adverse events related to cancer treatment in survivors of childhood and adolescent cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014921DOI Listing

Genetic Determinants of Ototoxicity During and After Childhood Cancer Treatment: Protocol for the PanCareLIFE Study.

JMIR Res Protoc 2019 Mar 19;8(3):e11868. Epub 2019 Mar 19.

Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.

Background: Survival rates after childhood cancer now reach nearly 80% in developed countries. However, treatments that lead to survival and cure can cause serious adverse effects with lifelong negative impacts on survivor quality of life. Hearing impairment is a common adverse effect in children treated with cisplatin-based chemotherapy or cranial radiotherapy. Read More

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http://dx.doi.org/10.2196/11868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444213PMC
March 2019
3 Reads

Endocrine consequences of neuroblastoma treatment in children: 20 years' experience of a single center.

J Pediatr Endocrinol Metab 2019 Apr;32(4):347-354

Division of Pediatric Endocrinology, University Department of Pediatrics, CHU Liège, Liège, Belgium.

Background Neuroblastoma (NBL) is a child neoplasia affecting extracranial tissue of neuroectodermal origin. It accounts for 10% of solid malignancies in children and is characterized by a survival rate approaching 70%, confronting physicians with the emergence of an adult survivor population who have been previously exposed to surgery, cytotoxic drugs, radiation therapy or metaiodobenzylguanidine (MIBG) therapy. All these treatments potentially affect the endocrine system. Read More

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http://dx.doi.org/10.1515/jpem-2018-0273DOI Listing
April 2019
1 Read

Schwannoma Formation in Childhood Cancer Survivors Exposed to Total Body Irradiation: Case Series.

J Adolesc Young Adult Oncol 2019 Mar 14. Epub 2019 Mar 14.

1 Reid R. Sacco Adolescent and Young Adult Cancer Program, Tufts Medical Center, Boston, Massachusetts.

Childhood cancer survivors are at risk for ongoing health risks related to their initial treatment. One potential long-term complication following radiation is the development of secondary tumors, including peripheral nerve tumors, such as schwannomas. We present three adolescent and young adult (AYA)-aged survivors of pediatric cancer (22-40 years), followed in our AYA survivorship clinic. Read More

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https://www.liebertpub.com/doi/10.1089/jayao.2018.0135
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http://dx.doi.org/10.1089/jayao.2018.0135DOI Listing
March 2019
3 Reads

Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer.

Cochrane Database Syst Rev 2019 03 11;3:CD008944. Epub 2019 Mar 11.

Department of Pediatrics, Division of Oncology/Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, Netherlands, 1081 HV.

Background: Improvements in diagnostics and treatment for paediatric malignancies resulted in a major increase in survival. However, childhood cancer survivors (CCS) are at risk of developing adverse effects caused by multimodal treatment for their malignancy. Nephrotoxicity is a known side effect of several treatments, including cisplatin, carboplatin, ifosfamide, radiotherapy and nephrectomy, and can cause glomerular filtration rate (GFR) impairment, proteinuria, tubulopathy, and hypertension. Read More

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http://dx.doi.org/10.1002/14651858.CD008944.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410614PMC

Osteonecrosis in pediatric cancer survivors: Epidemiology, risk factors, and treatment.

Surg Oncol 2019 Mar 4;28:214-221. Epub 2019 Feb 4.

Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Several treatment regimens for childhood malignancies have been associated with the development of osteonecrosis, including radiation therapy, glucocorticoid medications, immunotherapy (including anti-angiogenic agents), and several chemotherapeutic agents. Adolescents older than 10 years are at greatest risk of developing osteonecrosis within 1 year of initiating therapy. Screening with magnetic resonance imaging in this high-risk population may be a useful method for detecting osteonecrosis. Read More

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http://dx.doi.org/10.1016/j.suronc.2019.02.001DOI Listing

Tinnitus during and after childhood cancer: A systematic review.

Crit Rev Oncol Hematol 2019 Mar 11;135:1-7. Epub 2019 Jan 11.

Department of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.

Background: Tinnitus can occur during and after treatment for childhood cancer. Studies on the occurrence of, and risk factors for tinnitus during and after childhood cancer treatment are scarce. The aim of this study is to get insight into the frequency and risk factors of tinnitus during and after childhood cancer therapy, based on a review of all previously reported literature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10408428193001
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http://dx.doi.org/10.1016/j.critrevonc.2019.01.004DOI Listing
March 2019
7 Reads

Sleep, emotional distress, and physical health in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Psychooncology 2019 Apr 14;28(4):903-912. Epub 2019 Mar 14.

Department of Psychology and Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee.

Objective: Sleep disorders are associated with psychological and physical health, although reports in long-term survivors of childhood cancer are limited. We characterized the prevalence and risk factors for behaviors consistent with sleep disorders in survivors and examined longitudinal associations with emotional distress and physical health outcomes.

Methods: Survivors (n = 1933; median [IQR] age = 35 [30, 41]) and siblings (n = 380; age = 33 [27, 40]) from the Childhood Cancer Survivor Study completed measures of sleep quality, fatigue, and sleepiness. Read More

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http://dx.doi.org/10.1002/pon.5040DOI Listing
April 2019
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Challenges and opportunities in the care of survivors of adolescent and young adult cancers.

Pediatr Blood Cancer 2019 Jun 28;66(6):e27668. Epub 2019 Feb 28.

Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.

Adolescents and young adults (AYA) with cancer are an understudied group. Much of what is known about long-term outcomes after AYA cancer has been derived from cohorts of childhood cancer survivors, which seldom include patients at the older end of the AYA age spectrum. In general, AYA cancer survivors have a lower risk for premature mortality, subsequent primary neoplasms and chronic health conditions than childhood cancer survivors. Read More

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http://dx.doi.org/10.1002/pbc.27668DOI Listing
June 2019
6 Reads

Reproductive factors, exogenous hormone use and incidence of melanoma among women in the United States.

Br J Cancer 2019 Apr 28;120(7):754-760. Epub 2019 Feb 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Rockville, MD, USA.

Background: Although the photosensitising effects of oestrogens may increase the impact of ultraviolet radiation (UVR) on melanoma risk, few prospective studies have comprehensively assessed the association between oestrogen-related factors and melanoma.

Methods: We examined the associations between reproductive factors, exogenous oestrogen use and first primary invasive melanoma among 167 503 non-Hispanic white, postmenopausal women in the NIH-AARP Diet and Health Study. Satellite-based ambient UVR estimates were linked to geocoded residential locations of participants at study baseline. Read More

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http://dx.doi.org/10.1038/s41416-019-0411-zDOI Listing
April 2019
4 Reads

Perceptions of changes in clinical, informational, and supportive relationships after end of treatment among parents of young childhood cancer survivors.

Psychooncology 2019 Apr 14;28(4):913-919. Epub 2019 Mar 14.

Department of Population Health & Disease Prevention, University of California Irvine, Irvine, California.

Background: Parents of childhood cancer patients experience changes in relationships with their health-care team as the child transitions from treatment to long-term survivorship (LTS). These changes may affect parent receptivity of survivorship-health-related programs, yet little is known about the experience of changing clinical relationships for parents as treatment ends and children transition into LTS.

Methods: In-depth, semistructured interviews were conducted with 20 English-speaking parents of childhood cancer survivors less than 13 years old who were greater than 1-year posttreatment. Read More

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http://dx.doi.org/10.1002/pon.5042DOI Listing
April 2019
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Survival from cancer in young people: An overview of late effects focusing on reproductive health.

Acta Obstet Gynecol Scand 2019 May 8;98(5):573-582. Epub 2019 Apr 8.

Leeds Institute of Health Research, School of Medicine and Health, University of Leeds, Leeds, UK.

This paper provides a summary of the areas of survival from childhood, teenage and young adult cancers and the significant late effects that can arise from treatment; with particular focus on the area of reproductive health and the impact on both fertility and pregnancy. To complete this review, Web of Science and MEDLINE were used. Search terms included: "survival AND childhood OR teenage OR young adult cancer", "late effects", "childhood cancer", "teenage AND/OR young adult cancer", AND "fertility after cancer" OR "pregnancy AND cancer" OR "fertility preservation". Read More

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http://dx.doi.org/10.1111/aogs.13584DOI Listing
May 2019
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Late mortality and causes of death among 5-year survivors of childhood cancer diagnosed in the period 1960-1999 and registered in the Italian Off-Therapy Registry.

Eur J Cancer 2019 Mar 14;110:86-97. Epub 2019 Feb 14.

Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy. Electronic address:

Introduction: Advances in paediatric oncology led to the increase in long-term survival, revealing the burden of therapy-related long-term side effects. We evaluated overall and cause-specific mortality in a large cohort of Italian childhood cancer survivors (CCSs) and adolescent cancer survivors identified through the off-therapy registry.

Materials And Methods: CCSs alive 5 years after cancer diagnosis occurring between 1960 and 1999 were eligible; the last follow-up was between 2011 and 2014. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.021DOI Listing
March 2019
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Schooling in survivorship: Understanding caregiver challenges when survivors return to school.

Psychooncology 2019 Apr 7;28(4):847-853. Epub 2019 Mar 7.

Clinical Neuropsychologist, Kennedy Krieger Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Objective: Schooling after treatment can hold challenges for survivors of childhood cancer and caregivers who may need to act as advocates on their behalf. This study seeks to understand caregiver experiences of survivor's school-related challenges. This understudied area is critical given the 85% survivor rate for those diagnosed with childhood cancer and the disproportionate risk of learning difficulties faced by those with brain tumor or who receive therapy that targets the central nervous system. Read More

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http://dx.doi.org/10.1002/pon.5026DOI Listing

SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro.

Cancers (Basel) 2019 Feb 10;11(2). Epub 2019 Feb 10.

Molecular Inflammation Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Hansine Hansens veg 18, 9019 Tromsø, Norway.

Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine kinase (SYK) has previously been identified as a promising drug target in various inflammatory diseases and cancers but has so far not been extensively studied as a potential therapeutic target in neuroblastoma. Read More

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http://dx.doi.org/10.3390/cancers11020202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406899PMC
February 2019
1 Read

Guidelines for Treatment and Monitoring of Adult Survivors of Pediatric Brain Tumors.

Curr Treat Options Oncol 2019 Feb 9;20(1):10. Epub 2019 Feb 9.

Pediatric Endocrinology, Emory Children's Center/Emory Pediatric Institute, 2015 Uppergate Drive, Room 232, Atlanta, GA, 30322, USA.

Opinion Statement: Pathologies of pediatric brain tumors are more varied than those diagnosed in adults and survival outcomes more optimistic. Therapies for pediatric brain tumors are also diverse and treatment options are expanding. The growing number of adult survivors of childhood brain tumors is quite diverse. Read More

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http://dx.doi.org/10.1007/s11864-019-0602-0DOI Listing
February 2019
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Michael Reese Hospital and the Campaign to Warn the US Public of the Long-Term Health Effects of Ionizing Radiation, 1973-1977.

Am J Public Health 2019 Mar;109(3):398-405

Itai Bavli is with the Interdisciplinary Studies Graduate Program and the W. Maurice Young Centre of Applied Ethics, University of British Columbia, Vancouver, Canada. Shifra Shvarts is with the Moshe Prywes Center for Medical Education, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, and The Israel National Institute for Health Policy and Health Services Research, Tel Hashomer, Israel.

In July 1973, a study at the University of Chicago linked radiation treatment during childhood to a variety of diseases, including thyroid cancer. A few months later, a worker at Michael Reese Hospital in Chicago, Illinois found a registry of 5266 former patients who had been treated with radiation during the 1950s and 1960s. Hospital officials decided to contact these patients and arrange for follow-up medical examinations. Read More

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http://dx.doi.org/10.2105/AJPH.2018.304763DOI Listing
March 2019
1 Read

Long-term survivors of childhood, adolescent and young adult non-Hodgkin lymphoma.

Br J Haematol 2019 Feb 3. Epub 2019 Feb 3.

Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.

Progress in overall survival rates for childhood non-Hodgkin lymphoma (NHL) can be largely attributed to effective development and conduct of a number of international treatment studies. Knowledge gained from these studies has shifted the treatment paradigm from a "one-size fits all" strategy to a histologically dependent approach. More specifically, many now adhere to a risk-stratified approach, prescribing cumulative doses and intensities of chemotherapeutic exposures based upon the aggressiveness of disease. Read More

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http://dx.doi.org/10.1111/bjh.15775DOI Listing
February 2019
6 Reads

Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls.

Bone 2019 Apr 31;121:221-226. Epub 2019 Jan 31.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America; Department of Genetics, University of Pennsylvania, Philadelphia, PA, United States of America; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America. Electronic address:

Over the past two decades, a low frequency variant (rs1800012) within the first intron of the type I collagen alpha 1 (COLIA1) gene has been implicated in lower areal BMD (aBMD) and increased risk of osteoporotic fracture. This association is particularly strong in postmenopausal women, in whom net bone loss arises in the context of high bone turnover. High bone turnover also accompanies childhood linear growth; however, the role of rs1800012 in this stage of net bone accretion is less well understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193003
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http://dx.doi.org/10.1016/j.bone.2019.01.026DOI Listing
April 2019
12 Reads

The genetic changes of Wilms tumour.

Nat Rev Nephrol 2019 Apr;15(4):240-251

Wellcome Sanger Institute, Cambridge, UK.

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in the majority of cases, albeit at considerable cost in terms of late treatment-related effects in some children. However, one in ten children with Wilms tumour will die of their disease despite modern treatment approaches. Read More

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http://dx.doi.org/10.1038/s41581-019-0112-0DOI Listing
April 2019
1 Read

Treatment abandonment in childhood acute lymphoblastic leukaemia in China: a retrospective cohort study of the Chinese Children's Cancer Group.

Arch Dis Child 2019 Jan 31. Epub 2019 Jan 31.

Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology and Oncology of China Ministry of Health, and National Children's Medical Center, Shanghai, China.

Objectives: Before 2003, most children with acute lymphoblastic leukaemia (ALL) abandoned treatment, with only approximately 30% treated in China. With the development of national insurance for underprivileged patients, we assessed the current frequency and causes of treatment abandonment among patients with ALL who were enrolled in the Chinese Children's Cancer Group ALL protocol between 2015 and 2016.

Methods: Demographic, clinical and laboratory data on patients who abandoned treatment, as well as economic and sociocultural data of their families were collected and analysed. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316181DOI Listing
January 2019
5 Reads

Hypogonadism in Children with a Previous History of Cancer: Endocrine Management and Follow-Up.

Horm Res Paediatr 2019 Jan 31:1-11. Epub 2019 Jan 31.

Department of Paediatric Haematology and Oncology, Royal Hospital for Sick Children, Edinburgh, United Kingdom.

Hypogonadism after treatment for childhood cancer is a recognized complication and its cause may be subdivided into primary gonadal failure and central hypogonadism. Here, we provide an overview of the risk factors for the development of hypogonadism, assessment and potential interventions and give a summary of the current recommendations for management and follow-up of hypogonadism in childhood cancer survivors. Read More

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http://dx.doi.org/10.1159/000495943DOI Listing
January 2019
1 Read

Chronic fatigue and associated factors among long-term survivors of cancers in young adulthood.

Acta Oncol 2019 Jan 30:1-10. Epub 2019 Jan 30.

a National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology , Oslo University Hospital , Oslo , Norway.

Background: Chronic fatigue (CF) is scarcely explored among young adult cancer survivors (YACSs), and more knowledge is needed to develop targeted interventions for YACSs with CF. The present study aimed to investigate the prevalence of CF and associated factors in YACSs. Also, the change of fatigue with time was explored. Read More

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http://dx.doi.org/10.1080/0284186X.2018.1557344DOI Listing
January 2019
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Hypothalamic-pituitary function following childhood brain tumors: Analysis of prospective annual endocrine screening.

Pediatr Blood Cancer 2019 May 28;66(5):e27631. Epub 2019 Jan 28.

Divisions of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.

Background: Outcomes for childhood brain tumors are now associated with a five-year survival rate of 75%. Endocrine effects of brain tumors are common, occurring in 43% of patients by 10 years from tumor diagnosis. Optimal timing of screening for endocrinopathies remains undefined. Read More

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http://dx.doi.org/10.1002/pbc.27631DOI Listing
May 2019
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Health-Related Quality of Life Among Survivors of Cancer in Adolescence: An Integrative Literature Review.

J Pediatr Nurs 2019 Jan - Feb;44:97-106. Epub 2018 Nov 21.

Duke University School of Nursing, Durham, NC, USA.

Problem: Adolescence is a critical developmental period, but little research is available on the quality of life for individuals ages 10-19, especially those who have faced a life-threatening illness. This integrative review examines factors related to quality of life among survivors of a childhood cancer that occurred during adolescence.

Eligibility Criteria: The Garrard Matrix Method guided this review of studies that were conducted from 1990 to 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08825963183007
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http://dx.doi.org/10.1016/j.pedn.2018.11.009DOI Listing
November 2018
8 Reads

Pediatric Normal Tissue Effects in the Clinic (PENTEC): An International Collaboration to Analyse Normal Tissue Radiation Dose-Volume Response Relationships for Paediatric Cancer Patients.

Clin Oncol (R Coll Radiol) 2019 Mar 19;31(3):199-207. Epub 2019 Jan 19.

University of Maryland School of Medicine, Baltimore, MD, USA.

With advances in multimodality therapy, childhood cancer cure rates approach 80%. However, both radiotherapy and chemotherapy can cause debilitating or even fatal late adverse events that are critical to understand, mitigate or prevent. QUANTEC (Quantitative Analysis of Normal Tissue Effects in the Clinic) identified radiation dose constraints for normal tissues in adults and pointed out the uncertainties in those constraints. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09366555193002
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http://dx.doi.org/10.1016/j.clon.2019.01.002DOI Listing
March 2019
10 Reads

The perceived impact of infertility on romantic relationships and singlehood among adult survivors of childhood cancer.

Psychooncology 2019 Mar 1;28(3):622-628. Epub 2019 Feb 1.

Center for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

Objective: To examine whether adult survivors of childhood cancer perceive a direct impact of potential/confirmed infertility on their romantic relationships/singlehood.

Methods: Open-ended qualitative phone interviews were conducted with 57 adult survivors of childhood cancer and analyzed through thematic content analysis until saturation was reached (N = 30).

Results: Interviews revealed three major themes: (1) impact on survivors, (2) impact on partners/romantic relationships, and (3) alternative routes to parenthood. Read More

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http://dx.doi.org/10.1002/pon.4999DOI Listing
March 2019
3 Reads

Drug Repurposing for Retinoblastoma: Recent Advances.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

CSIR- Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad 500 007. India.

Retinoblastoma is the intraocular malignancy that occurs during early childhood. The current standard of care includes chemotherapy followed by focal consolidative therapies, and enucleation. Unfortunately, these are associated with many side and late effects. Read More

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http://www.eurekaselect.com/169178/article
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http://dx.doi.org/10.2174/1568026619666190119152706DOI Listing
January 2019
6 Reads

Knowledge of Late Effects Risks and Healthcare Responsibility in Adolescents and Young Adults Treated for Childhood Cancer.

J Pediatr Psychol 2019 Jan 8. Epub 2019 Jan 8.

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta.

Objective: This study aimed to examine the level and predictors of knowledge of late effects risks from childhood cancer treatment in adolescent and young adult (AYA) survivors.

Methods: Seventy-three AYAs, aged 14-21, completed measures of knowledge of late effect risks, executive functioning, and responsibility for health self-management. Sixty-seven parents of these AYA survivors (91. Read More

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http://dx.doi.org/10.1093/jpepsy/jsy102DOI Listing
January 2019
2 Reads

Risk and Temporal Changes of Heart Failure Among 5-Year Childhood Cancer Survivors: a DCOG-LATER Study.

J Am Heart Assoc 2019 Jan;8(1):e009122

1 Department of Pediatric Oncology Emma Children's Hospital Amsterdam UMC University of Amsterdam The Netherlands.

Background Heart failure is one of the most important late effects after treatment for cancer in childhood. The goals of this study were to evaluate the risk of heart failure, temporal changes by treatment periods, and the risk factors for heart failure in childhood cancer survivors ( CCS ). Methods and Results The DCOG-LATER (Dutch Childhood Oncology Group-Long-Term Effects After Childhood Cancer) cohort includes 6,165 5-year CCS diagnosed between 1963 and 2002. Read More

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http://dx.doi.org/10.1161/JAHA.118.009122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405698PMC
January 2019
2 Reads

p53, stem cell biology and childhood blastomas.

Curr Opin Oncol 2019 Mar;31(2):84-91

Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia.

Purpose Of Review: Childhood blastomas, unlike adult cancers, originate from developing organs in which molecular and cellular features exhibit differentiation arrest and embryonic characteristics. Conventional cancer therapies, which rely on the generalized cytotoxic effect on rapidly dividing cells, may damage delicate organs in young children, leading to multiple late effects. Deep understanding of the biology of embryonal cancers is crucial in reshaping the cancer treatment paradigm for children. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000504DOI Listing

Survivor clinic attendance among pediatric- and adolescent-aged survivors of childhood cancer.

J Cancer Surviv 2019 Feb 17;13(1):56-65. Epub 2018 Dec 17.

Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.

Purpose: Childhood cancer survivors need regular, risk-adapted, long-term survivor care. This retrospective study describes the proportion of survivors seen for an initial survivor clinic visit within a large pediatric oncology program.

Methods: Patients diagnosed with non-central nervous system childhood malignancies from 2007 to 2012 were followed from the time of survivor clinic eligibility (2 years following completion of therapy) through their initial survivor clinic visit or end of study. Read More

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http://link.springer.com/10.1007/s11764-018-0727-3
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http://dx.doi.org/10.1007/s11764-018-0727-3DOI Listing
February 2019
12 Reads

Respiratory morbidity in young people surviving cancer: Population-based study of hospital admissions, treatment-related risk factors and subsequent mortality.

Int J Cancer 2018 Dec 14. Epub 2018 Dec 14.

Clinical and Population Science Department, School of Medicine, University of Leeds, Leeds, United Kingdom.

Respiratory diseases are a major cause of late morbidity and mortality amongst childhood cancer survivors. This population-based study investigates respiratory hospital admissions in long-term survivors of cancers diagnosed in young people to identify specific respiratory morbidities, treatment-related risks and their relationship to subsequent morbidity and mortality. Population-based cancer registrations in Yorkshire, England, diagnosed between 1990 and 2011 aged 0-29 years, were linked to inpatient Hospital Episode Statistics (HES) for admissions up to 2017. Read More

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http://dx.doi.org/10.1002/ijc.32066DOI Listing
December 2018
1 Read

Thyroid Sequelae of Pediatric Cancer Therapy.

Horm Res Paediatr 2018 Dec 12:1-14. Epub 2018 Dec 12.

Department of Endocrine Neoplasia and Hormonal Disorders and the Department of Pediatrics-Patient Care, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA,

The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as 131I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Read More

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http://dx.doi.org/10.1159/000495040DOI Listing
December 2018
17 Reads

Long-term health and social function in adult survivors of paediatric astrocytoma: A report from the Childhood Cancer Survivor Study.

Eur J Cancer 2019 Jan 5;106:171-180. Epub 2018 Dec 5.

Division of Haematology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Division of Oncology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Paediatrics, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Health Policy, Management, and Evaluation, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

Background: Although paediatric astrocytoma has an excellent 5-year survival rate, survivors remain at risk for morbidity and late mortality. This study aimed to estimate the risk of late mortality, chronic conditions, poor health status and social impairment in ageing paediatric astrocytoma survivors.

Methods: We longitudinally evaluated 1182 5-year astrocytoma survivors diagnosed between 1970 and 1986 and 4023 siblings enrolled in a retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.10.016DOI Listing
January 2019

Long-term complications in adolescent and young adult leukemia survivors.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):146-153

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Adolescents and young adults (AYAs) with cancer, defined by the National Cancer Institute as having been diagnosed between the ages of 15 and 39 years old, have not benefited from the same improvements in quality of outcomes and survival that have been seen for individuals diagnosed in childhood or as older adults. Although is leukemia composed of a diverse group of diagnoses, leukemia AYA survivors share unique vulnerabilities with other AYA diagnostic groups. They will spend the majority of their lives as survivors, with clear evidence of adverse medical conditions, health care requirements, and social and psychological needs that differ not only from their peers but also, from the needs of other cancer survivor populations. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245964PMC
November 2018
2 Reads

Long-term Endocrine and Metabolic consequences of Cancer Treatment: A Systematic Review.

Endocr Rev 2018 Nov 23. Epub 2018 Nov 23.

Exp. & Clin Endocrinology, University Hospital of Schleswig-Holstein, Campus Luebeck, Germany.

The number of patients surviving five or more years after initial cancer diagnosis has significantly increased over the last decades due to considerable improvements in the treatment of many cancer entities. A negative consequence of this is the emergence of long-term sequelae and endocrine disorders account for a high proportion of these. These late effects can occur decades after cancer treatment and affect up to 50% of childhood cancer survivors. Read More

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https://academic.oup.com/edrv/advance-article/doi/10.1210/er
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http://dx.doi.org/10.1210/er.2018-00092DOI Listing
November 2018
12 Reads

Reproductive Outcomes After a Childhood and Adolescent Young Adult Cancer Diagnosis in Female Cancer Survivors: A Systematic Review and Meta-analysis.

J Adolesc Young Adult Oncol 2018 Nov 16. Epub 2018 Nov 16.

2 Kids Cancer Centre, Sydney Children's Hospital , Sydney, Australia .

Improvements in cancer therapy for childhood and adolescent and young adult (AYA) survivors have increased in excess of 80% among pediatric patients and in excess of 85% among AYA cancer patients. Our research group explored the late effects consequences of cancer treatment on pregnancy and birth outcomes subsequent to a childhood (0-14 years) or AYA (15-25 years) diagnosis of cancer in female cancer survivors. Embase and Medline databases were searched. Read More

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https://www.liebertpub.com/doi/10.1089/jayao.2018.0036
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http://dx.doi.org/10.1089/jayao.2018.0036DOI Listing
November 2018
12 Reads

Childhood Cancer Treatments and Associated Endocrine Late Effects: A Concise Guide for the Pediatric Endocrinologist.

Horm Res Paediatr 2018 Nov 7:1-9. Epub 2018 Nov 7.

Department of Pediatrics, Memorial-Sloan Kettering Cancer Center, New York, New York, USA.

Endocrine complications are frequently observed in childhood cancer survivors (CCS); in many instances, these complications develop months to years after the completion of cancer therapy. The estimated prevalence of endocrine late effects is 50% among CCS; the main risk factors are external beam radiation that includes key endocrine organs (the hypothalamus/pituitary, thyroid and gonads) and/or alkylating agents. Novel agents targeting tumor growth have increased the options available to a small number of patients albeit with the need for treatment over long periods of time. Read More

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https://www.karger.com/Article/FullText/493943
Publisher Site
http://dx.doi.org/10.1159/000493943DOI Listing
November 2018
22 Reads

Late Effects of Therapy in Childhood Acute Lymphoblastic Leukemia Survivors

Turk J Haematol 2019 02 1;36(1):1-11. Epub 2018 Aug 1.

Texas Children’s Hematology and Oncology Centers, Baylor College of Medicine, Department of Pediatrics, Division of Hematology and Oncology, Houston, TX, USA

Over the last 50 years, the survival rates in children with acute lymphoblastic leukemia (ALL) have increased remarkably. The optimal use of antileukemic agents in cooperative group protocols, central nervous system-directed treatment, improvements in supportive care, and recognition of biological, clinical, and treatment response characteristics that predict patients with a higher or a lower risk of treatment failure have improved 5-year event-free survival rates, reaching more than 85%, and 5-year overall survival rates, reaching more than 90%. Consequently, it has become increasingly important to characterize the occurrence of long-term late effects. Read More

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https://www.journalagent.com/z4/download_fulltext.asp?pdir=t
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http://dx.doi.org/10.4274/tjh.galenos.2018.2018.0150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373511PMC
February 2019
32 Reads

Acquired Platythorax, or Anteroposterior Flattening of the Chest Wall, as a Late Complication of Cyclophosphamide Treatment for Childhood Acute Lymphoblastic Leukemia, Presenting in a Young Man with Respiratory Failure.

Am J Case Rep 2018 Nov 5;19:1317-1323. Epub 2018 Nov 5.

Department of Clinical Engineering, Suzuka University of Medical Science, Suzuka, Mie, Japan.

BACKGROUND Acquired platythorax, or flattening of the chest with a reduction in the anteroposterior (AP) diameter, is very rare and the prognosis depends on the degree of the deformity, respiratory function, and on any underlying disease. Drug-induced pulmonary fibrosis is associated with pulmonary hypoplasia. A case of acquired platythorax is presented in a young man previously treated with cyclophosphamide in childhood. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911701
Publisher Site
http://dx.doi.org/10.12659/AJCR.911701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238677PMC
November 2018
16 Reads

Long-term effects of cancer on earnings of childhood, adolescent and young adult cancer survivors - a population-based study from British Columbia, Canada.

BMC Health Serv Res 2018 Nov 1;18(1):826. Epub 2018 Nov 1.

Pediatric Oncology and Hematology, BC Children's Hospital, Vancouver, BC, Canada.

Background: The patterns and determinants of long-term income among young people surviving cancer, and differences compared to peers, have not yet been fully explored. The objectives of this paper are to describe long-term income among young survivors of cancer, the impact of socio-demographic, disease, and treatment factors on long-term income, and income relative to the general population.

Methods: Retrospective cohort study with comparison group from the general population, using linked population-based registries, clinical data, and tax-records. Read More

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http://dx.doi.org/10.1186/s12913-018-3617-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211561PMC
November 2018
15 Reads