2,086 results match your criteria Late Effects of Childhood Cancer and Treatment


A longitudinal analysis of early lung function trajectory in survivors of childhood Hodgkin lymphoma.

Cancer Rep (Hoboken) 2022 Jun 27:e1661. Epub 2022 Jun 27.

Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Background: Childhood Hodgkin lymphoma survivors suffer from long-term effects decades after treatment completion with a prevalence of pulmonary dysfunction of up to 65.2%.

Aims: This study explored the early trajectory of pulmonary function in pediatric cancer patients with Hodgkin lymphoma who received pulmonary toxic therapy. Read More

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The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study.

Cancers (Basel) 2022 Jun 9;14(12). Epub 2022 Jun 9.

Department of Hematology, Radboud University Medical Center, Geert-Grooteplein Zuid 8, 6500 HB Nijmegen, The Netherlands.

Background: Early detection and management of late effects of treatment and their impact on health-related quality of life (HRQOL) has become a key goal of childhood cancer survivorship care. One of the most prevalent late effects is chronic fatigue (CF). The current study aimed to investigate the association between CF and HRQOL in a nationwide cohort of CCS. Read More

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Factors Associated with Interest in Complementary and Alternative Medicine Among Young Adult Survivors of Childhood Cancer.

J Pediatr Hematol Oncol Nurs 2022 Jan-Feb;39(1):30-39

Department of Epidemiology and Biostatistics, Susan and Henry Samueli College of Health Sciences, 8788University of California, Irvine, Irvine, CA, USA.

Use of complementary and alternative medicine (CAM) by those undergoing cancer treatment is common. While some childhood cancer survivors (CCS) may use CAM to treat late effects, others may lack information about available alternative therapies. We sought to determine characteristics associated with seeking more information about CAM among an ethnically diverse sample of young adult CCS. Read More

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Leveraging therapy-specific polygenic risk scores to predict restrictive lung defects in childhood cancer survivors.

Cancer Res 2022 Jun 17. Epub 2022 Jun 17.

St. Jude Children's Research Hospital, Memphis, United States.

Therapy-related pulmonary complications are among the leading causes of morbidity among long-term survivors of childhood cancer. Restrictive ventilatory defects (RVD) are prevalent, with risks increasing after exposures to chest radiation therapy and radiomimetic chemotherapies. Using whole-genome sequencing data from 1,728 childhood cancer survivors in the St. Read More

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Sociocultural variables have a major impact on participation in patients treated for paediatric posterior fossa tumours.

Child Care Health Dev 2022 Jun 16. Epub 2022 Jun 16.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Background: This study investigates the severeness of participation barriers in patients surviving paediatric posterior fossa tumours (PFT) many years after treatment. In the past, aetiological studies on adverse outcome have primarily focused on pathobiological risk factors. The current analysis aims to investigate the importance of environmental variables. Read More

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A National Implementation Approach for Exercise as Usual Care in Pediatric and Adolescent Oncology: Network ActiveOncoKids.

Pediatr Exerc Sci 2022 Jun 14:1-8. Epub 2022 Jun 14.

Department of Sport and Health Sciences, Institute of Preventive Pediatrics, Technical University of Munich, Munich,Germany.

The diagnosis of cancer as well as accompanying acute and late effects of treatment are influencing physical activity behavior of patients with childhood cancer and survivors. Research has shown that a pediatric cancer diagnosis is associated with impairments of physical performance, and function, as well as reduced physical, and psychosocial, health conditions. From an ethical perspective, lack of knowledge of health care providers, lack of physical activity promotion, and environmental, and structural barriers to physical activity restrict children's right to move and actively engage in physical activities. Read More

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Late pulmonary complications related to cancer treatment in children.

Pediatr Radiol 2022 Jun 14. Epub 2022 Jun 14.

Edward B. Singleton Department of Radiology, Texas Children's Hospital, 6701 Fannin St., Houston, TX, 77030, USA.

As the number of childhood cancer survivors increases, a heightened awareness and recognition of therapy-related late effects is becoming more important. Pulmonary complications are the third leading cause of late mortality in cancer survivors. Diagnosis of these complications on chest imaging helps facilitate prompt treatment to mitigate adverse outcomes. Read More

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A novel locus on 6p21.2 for cancer treatment-induced cardiac dysfunction among childhood cancer survivors.

J Natl Cancer Inst 2022 Jun 14. Epub 2022 Jun 14.

St. Jude Children's Research Hospital, Memphis, TN, USA.

Background: Adult survivors of childhood cancer are at increased risk of cardiac late effects.

Methods: Using whole-genome sequencing data from 1,870 survivors of European ancestry in the St. Jude Lifetime Cohort (SJLIFE) study, genetic variants were examined for association with ejection fraction (EF) and clinically assessed cancer therapy-induced cardiac dysfunction (CCD). Read More

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Endocrine Late Effects in Childhood Cancer Survivors.

Cancers (Basel) 2022 May 26;14(11). Epub 2022 May 26.

Oncology Department, Pediatric Cancer Center Barcelona, Hospital Sant Joan de Déu, University of Barcelona, 08950 Barcelona, Spain.

Childhood cancer management has improved considerably over the years, leading to a significant improvement in survival of up to 80%. However, childhood cancer survivors are at the highest risk of developing sequelae resulting from treatment, with endocrine complications being frequently observed among survivors. Multiple predisposing factors for endocrine sequelae have been identified, including age at diagnosis, treatment received, radiation, tumor type, and genetic polymorphisms, which could explain the individual predisposition to develop drug toxicity. Read More

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Asymptomatic Survivors of Childhood Acute Lymphoblastic Leukemia Demonstrate a Biological Profile of Inflamm-Aging Early in Life.

Cancers (Basel) 2022 May 20;14(10). Epub 2022 May 20.

Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Białystok, Poland.

Childhood acute lymphoblastic leukemia (ALL) survivors are at higher risk of developing many late effects later in life. They experience multiple health problems that have significant public health implications, such as frailty, premature onset of lifestyle diseases, and second tumors. There is some evidence that chronic inflammation causes accelerated aging in childhood cancer survivors; however, the available data are very limited. Read More

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Health care expenditures among long-term survivors of pediatric solid tumors: Results from the French Childhood Cancer Survivor Study (FCCSS) and the French network of cancer registries (FRANCIM).

PLoS One 2022 26;17(5):e0267317. Epub 2022 May 26.

Radiation Epidemiology Team, CESP, Inserm U1018, Villejuif, France.

Background: Childhood cancer survivors (CCS) may require lifelong medical care due to late effects of cancer treatments. Little is known about of their healthcare utilization and expenditures at long-term especially in publicly funded health care system. We aim to estimate and describe the health care expenditures among long-term CCS in France. Read More

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Image-based data mining applies to data collected from children.

Phys Med 2022 Jul 21;99:31-43. Epub 2022 May 21.

Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Purpose: Image-based data mining (IBDM) is a novel voxel-based method for analyzing radiation dose responses that has been successfully applied in adult data. Because anatomic variability and side effects of interest differ for children compared to adults, we investigated the feasibility of IBDM for pediatric analyses.

Methods: We tested IBDM with CT images and dose distributions collected from 167 children (aged 10 months to 20 years) who received proton radiotherapy for primary brain tumors. Read More

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Realist Review of Care Models That Include Primary Care for Adult Childhood Cancer Survivors.

JNCI Cancer Spectr 2022 03;6(2)

Department of Medicine, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Appropriate models of survivorship care for the growing number of adult survivors of childhood cancer are unclear. We conducted a realist review to describe how models of care that include primary care and relevant resources (eg, tools, training) could be effective for adult survivors of childhood cancer. We first developed an initial program theory based on qualitative literature (studies, commentaries, opinion pieces) and stakeholder consultations. Read More

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Identifying causal relationships of cancer treatment and long-term health effects among 5-year survivors of childhood cancer in Southern Sweden.

Commun Med (Lond) 2022 2;2:21. Epub 2022 Mar 2.

Department of Clinical Sciences Lund, Pediatrics, Faculty of Medicine, Lund University, Lund, Sweden.

Background: Survivors of childhood cancer can develop adverse health events later in life. Infrequent occurrences and scarcity of structured information result in analytical and statistical challenges. Alternative statistical approaches are required to investigate the basis of late effects in smaller data sets. Read More

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Childhood cancer survivorship in China: An overview of the past two decades.

Cancer Med 2022 May 22. Epub 2022 May 22.

Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.

Across countries in the world, China has the largest population of childhood cancer survivors. Research and care for the childhood cancer survivor population in China is fragmented. We searched studies published in English or Chinese language between January 1, 2000 and June 30, 2021, which examined various aspects of childhood cancer survivorship in China. Read More

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Neurocognitive deficits in survivors of childhood acute myeloid leukemia.

BMC Pediatr 2022 May 21;22(1):298. Epub 2022 May 21.

Children's Cancer Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Although treatment of acute myeloid leukemia (AML) contains neurotoxic agents, studies investigating neurocognitive outcomes in children with AML are sparse. We evaluated late cognitive effects in children treated with a high-dose cytarabine based regimen, focusing on general intellectual ability and specific neurocognitive domains.

Methods: We evaluated 12 survivors of childhood AML who were treated between 2006 and 2016 and completed the Wechsler Intelligence Scales. Read More

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Distribution and frequency of tyrosine kinase inhibitor-associated long-term complications in children with chronic myeloid leukemia.

Pediatr Blood Cancer 2022 May 20:e29786. Epub 2022 May 20.

Division of Cancer and Hematology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.

Background: Tyrosine kinase inhibitors (TKIs) improve outcomes for pediatric malignancies characterized by specific gene rearrangements and mutations; however, little is known about the long-term impact of TKI exposure. Our objective was to assess the incidence and type of late-onset TKI-related toxicities in children with chronic myeloid leukemia (CML).

Methods: We reviewed medical records from patients diagnosed with CML between 2006 and 2019 at <21 years of age and prescribed one or more TKIs. Read More

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Factors Influencing Implementation of the Survivorship Passport: The IT Perspective.

Stud Health Technol Inform 2022 May;293:161-168

IRCCS, Istituto Giannina Gaslini, Genova, Italy.

Compared to the general population, childhood cancer survivors represent a vulnerable population as they are at increased risk of developing health problems, known as late effects, resulting in excess morbidity and mortality. The Survivorship Passport aims to capture key health data about the survivors and their treatment, as well as personalized recommendations and a care plan with the aim to support long-term survivorship care. The PanCareSurPass (PCSP) project building on the experience gained in an earlier implementation in Giannina Gaslini Institute, Italy, will implement and rigorously assess an integrated, HL7 FHIR based, implementation of the Survivorship Passport. Read More

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Integrating primary care and childhood cancer survivorship care: a scoping review protocol.

BMJ Open 2022 05 16;12(5):e059050. Epub 2022 May 16.

Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Introduction: Improved treatment regimens have led to increased survival rates among childhood cancer survivors (CCS), and more than 84% of all children diagnosed with cancer will experience long-term survival or cure. Survivors are susceptible to late effects of cancer treatment often requiring lifelong follow-up care, as many of these conditions can be prevented or mitigated with surveillance. Integrating primary care (PC) and childhood cancer survivorship care can improve follow-up for survivors, however, little integrative research exists. Read More

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Protocol of a mixed-method randomised controlled pilot study evaluating a wilderness programme for adolescent and young adult cancer survivors: the WAYA study.

BMJ Open 2022 05 9;12(5):e061502. Epub 2022 May 9.

Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.

Introduction: The majority of childhood, adolescent and young adult (AYA) cancer survivors suffer from long-term and late effects such as fatigue, psychological distress or comorbid diseases. Effective health promotion strategies are needed to support the health of this vulnerable group. This protocol provides a methodological description of a study that aims to examine the feasibility and safety of performing a randomised clinical trial (RCT) on a wilderness programme that is developed to support the health of AYA cancer survivors. Read More

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Acute and Late Pulmonary Effects After Radiation Therapy in Childhood Cancer Survivors: A PENTEC Comprehensive Review.

Int J Radiat Oncol Biol Phys 2022 May 4. Epub 2022 May 4.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

Objectives: The Pediatric Normal Tissue Effects in the Clinic (PENTEC) pulmonary task force reviewed dosimetric and clinical factors associated with radiation therapy (RT)-associated pulmonary toxicity in children.

Methods: Comprehensive search of PubMed (1965-2020) was conducted to assess available evidence and predictive models of RT-induced lung injury in pediatric cancer patients (<21 years old). Lung dose for radiation pneumonitis (RP) was obtained from dose-volume histogram (DVH) data. Read More

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An integrated approach to cardioprotection in lymphomas.

Lancet Haematol 2022 Jun 2;9(6):e445-e454. Epub 2022 May 2.

Radiation Oncology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

In potentially curable cancers, long-term survival depends not only on the successful treatment of the malignancy but also on the risks associated with treatment-related toxicity, especially cardiotoxicity. Malignant lymphomas affect patients at any age, with acute and late toxicity risks that could have a severe effect on morbidity, mortality, and quality of life. Although our understanding of chemotherapy-associated and radiotherapy-associated cardiovascular disease has advanced considerably, new drugs with potential cardiotoxicity have been introduced for the treatment of lymphomas. Read More

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International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines.

Ecancermedicalscience 2022 17;16:1356. Epub 2022 Feb 17.

Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Most children with tumors will require one or more surgical interventions as part of the care and treatment, including making a diagnosis, obtaining adequate venous access, performing a surgical resection for solid tumors (with staging and reconstruction), performing procedures for cancer prevention and its late effects, and managing complications of treatment; all with the goal of improving survival and quality of life. It is important for surgeons to adhere to sound pediatric surgical oncology principles, as they are closely associated with improved local control and survival. Unfortunately, there is a significant disparity in survival rates in low and middle income countries, when compared to those from high income countries. Read More

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February 2022

Development of a questionnaire to evaluate female fertility care in pediatric oncology, a TREL initiative.

BMC Cancer 2022 Apr 25;22(1):450. Epub 2022 Apr 25.

Vilnius University, Faculty of Medicine, Vilnius, Lithuania.

Background: Currently the five-year survival of childhood cancer is up to 80% due to improved treatment modalities. However, the majority of childhood cancer survivors develop late effects including infertility. Survivors describe infertility as an important and life-altering late effect. Read More

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Advanced heart failure and cardiac arrhythmia in a young adult survivor of childhood cancer.

Vnitr Lek 2022 ;68(E-1):22-26

The goal of this case report is to describe the young childhood cancer survivor who was treated for nonHodgkin lymphoma with chemotherapy containing anthracycline doxorubicin and who developed symptoms of serious cardiovascular damage 27 years after diagnosis of cancer. The patient is in longterm complete remission of the lymphoma. He started guideline medical therapies for chronic heart failure and had a cardioverter defibrillator implanted for primary prevention of sudden cardiac death. Read More

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Recommendations for the surveillance of education and employment outcomes in survivors of childhood, adolescent, and young adult cancer: A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

Cancer 2022 Jul 18;128(13):2405-2419. Epub 2022 Apr 18.

Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Educational achievement and employment outcomes are critical indicators of quality of life in survivors of childhood, adolescent, and young adult (CAYA) cancer. This review is aimed at providing an evidence-based clinical practice guideline (CPG) with internationally harmonized recommendations for the surveillance of education and employment outcomes in survivors of CAYA cancer diagnosed before the age of 30 years. The CPG was developed by a multidisciplinary panel under the umbrella of the International Late Effects of Childhood Cancer Guideline Harmonization Group. Read More

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Long-term care for people treated for cancer during childhood and adolescence.

Lancet 2022 04;399(10334):1561-1572

Department of Medicine, Duke University, Durham, NC, USA.

Worldwide advances in treatment and supportive care for children and adolescents with cancer have resulted in a increasing population of survivors growing into adulthood. Yet, this population is at very high risk of late occurring health problems, including significant morbidity and early mortality. Unique barriers to high-quality care for this group include knowledge gaps among both providers and survivors as well as fragmented health-care delivery during the transition from paediatric to adult care settings. Read More

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Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET.

Support Care Cancer 2022 Jul 15;30(7):6155-6162. Epub 2022 Apr 15.

Dep. of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway.

Purpose: To investigate taste and smell function in survivors, with a minimum of 2 years since treatment of childhood medulloblastoma (MB)/central nervous system supratentorial primitive neuroectodermal tumor (CNS-PNET).

Methods: This cross-sectional study included 40 survivors treated ≤ 20 years of age. Taste strips with four concentrations of sweet, sour, salt, and bitter were used to assess taste function in all participants. Read More

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Late Toxicity After 3-Dimensional External Beam Radiotherapy Among Children With Cancer: A Systematic Review.

J Pediatr Hematol Oncol 2022 05 6;44(4):117-134. Epub 2022 Apr 6.

Princess Máxima Center for Pediatric Oncology.

Radiotherapy has evolved from 2-dimensional conventional radiotherapy (2D-RT) to 3-dimensional planned radiotherapy (3D-RT). Because 3D-RT improves conformity, an altered late health outcomes risk profile is anticipated. Here, we systematically reviewed the current literature on late toxicity after 3D-RT in children treated for cancer. Read More

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