Cancers (Basel) 2022 May 26;14(11). Epub 2022 May 26.
Oncology Department, Pediatric Cancer Center Barcelona, Hospital Sant Joan de Déu, University of Barcelona, 08950 Barcelona, Spain.
Childhood cancer management has improved considerably over the years, leading to a significant improvement in survival of up to 80%. However, childhood cancer survivors are at the highest risk of developing sequelae resulting from treatment, with endocrine complications being frequently observed among survivors. Multiple predisposing factors for endocrine sequelae have been identified, including age at diagnosis, treatment received, radiation, tumor type, and genetic polymorphisms, which could explain the individual predisposition to develop drug toxicity. Read More