1,763 results match your criteria Late Effects of Childhood Cancer and Treatment


Childhood cancer: Survival, treatment modalities, late effects and improvements over time.

Cancer Epidemiol 2020 May 24:101733. Epub 2020 May 24.

Childhood Cancer Research Group, Danish Cancer Society Research Center, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University and University Hospital, Denmark.

Since the 1960s, paediatric oncologists have gradually become better organised in large study groups and participation in clinical trials is today considered as the standard of care, with most children with cancer in Europe and North America being enrolled on available treatment protocols. Chemotherapy is nowadays the main element of therapy, but irradiation is still required for some patients. With the advent of multimodality therapy and supportive care, five-year cancer survival exceeds 80 % in most European and North American countries today. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101733DOI Listing

Treatment patterns and outcomes in adolescents and young adults with Hodgkin lymphoma in pediatric versus adult centers: An IMPACT Cohort Study.

Cancer Med 2020 May 22. Epub 2020 May 22.

Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.

Hodgkin lymphoma (HL) is a common adolescent and young adult (AYA) cancer. While outcome disparities between pediatric vs. adult centers [locus of care (LOC)] have been demonstrated in other AYA cancers such as acute lymphoblastic leukemia, they have not been well studied in HL. Read More

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http://dx.doi.org/10.1002/cam4.3138DOI Listing

Patient and Parent Decision-Making in the Setting of Chemotherapy-Induced Sensorineural Hearing Loss.

Ear Hear 2020 May 15. Epub 2020 May 15.

Washington University School of Medicine, St. Louis, Missouri, USA.

Objectives: Children with malignancies may be exposed to ototoxic therapies resulting in sensorineural hearing loss (SNHL). There is no consensus as to when intervention with amplification is necessary due to a variety of factors such as disease status, speech and language development, perceived difficulty with communication, and limitations of technology to fit these challenging losses. The decision to proceed with amplification after cancer can be difficult for patients and families. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000886DOI Listing

Impacts of Physical Late Effects on Presenteeism in Childhood Cancer Survivors.

Pediatr Int 2020 May 13. Epub 2020 May 13.

Department of Family Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Background: Many childhood cancer survivors (CCSs) experience physical late effects related to their cancer types and treatment modalities. Physical late effects are an important factor in various occupational outcomes among CCSs. However, the relationship between physical late effects and presenteeism has remained unclear. Read More

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http://dx.doi.org/10.1111/ped.14293DOI Listing

Neurocognitive Outcomes in Children with Brain Tumors.

Semin Neurol 2020 Jun 11;40(3):315-321. Epub 2020 May 11.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, California.

Brain tumors are the most common solid tumor in childhood, and although survival outcomes continue to improve, survival is frequently offset by devastating late effects from tumor and treatment. The long-term effects of brain tumors and the therapy necessary to treat them range from sensory and neuroendocrine abnormalities to neurocognitive deficits leading to inferior quality of life. The multifactorial neurocognitive injury is one of the most broadly impacting and challenging late effects to predict and subsequently treat. Read More

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http://dx.doi.org/10.1055/s-0040-1708867DOI Listing

INTESTINAL DYSBIOSIS AND DEVELOPMENT OF CARDIOMETABOLIC DISORDERS IN CHILDHOOD CANCER SURVIVORS: A CRITICAL REVIEW.

Antioxid Redox Signal 2020 May 10. Epub 2020 May 10.

Research Centre, CHU Ste-Justine, Nutrition, Université de Montréal, 3175, Ste-Catherine Road, Montreal, Quebec, Canada, H3T 1C5.

Significance: Survivors of pediatric cancers have a high risk of developing side effects after the end of their treatments. Many potential factors have been associated with the onset of cardiometabolic disorders (CMD), including cancer disease itself, chemotherapy, hormonal treatment, radiotherapy and genetics. However, the precise etiology and underlying mechanisms of these long-term complications are poorly understood. Read More

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http://dx.doi.org/10.1089/ars.2020.8102DOI Listing

Epidemiologic Characteristics of Acute Kidney Injury During Cisplatin Infusions in Children Treated for Cancer.

JAMA Netw Open 2020 May 1;3(5):e203639. Epub 2020 May 1.

Peter Gilgan Centre For Research and Learning, Toronto, Ontario, Canada.

Importance: Few multicenter pediatric studies have comprehensively described the epidemiologic characteristics of cisplatin-associated acute kidney injury using standardized definitions.

Objective: To examine the rate of and risk factors associated with acute kidney injury among children receiving cisplatin infusions.

Design, Setting, And Participants: This prospective cohort study examined children (aged <18 years) recruited from May 23, 2013, to March 31, 2017, at 12 Canadian pediatric academic health centers who were receiving 1 or more cisplatin infusion. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.3639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210480PMC

Sexual Dysfunction in Adolescent and Young Adult Survivors of Childhood Cancer: Presentation, Risk Factors, and Evaluation of an Underdiagnosed Late Effect: A Narrative Review.

J Adolesc Young Adult Oncol 2020 May 7. Epub 2020 May 7.

Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

An area of concern affecting the quality of life of childhood cancer survivors (CCS) is that of sexual dysfunction (SD), which may be a result of both physical and psychosexual challenges associated with cancer and its treatment. This is especially pertinent as CCS are known to experience diminished quality of life compared to peers. Relevant to SD, cancer and its associated treatment are associated with negative effects on body image and romantic relationships, as well as overall physical and mental health. Read More

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http://dx.doi.org/10.1089/jayao.2020.0025DOI Listing

Strategies to Prevent or Remediate Cancer and Treatment-Related Aging.

J Natl Cancer Inst 2020 Apr 29. Epub 2020 Apr 29.

Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Up to 85% of adult cancer survivors and 99% of adult survivors of childhood cancer live with an accumulation of chronic conditions, frailty, and/or cognitive impairments resulting from cancer and its treatment. Thus, survivors often show an accelerated development of multiple geriatric syndromes and need therapeutic interventions. To advance progress in this area, the National Cancer Institute convened the second of two think tanks under the auspices of the Cancer and Accelerated Aging: Advancing Research for Healthy Survivors initiative. Read More

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http://dx.doi.org/10.1093/jnci/djaa060DOI Listing
April 2020
12.583 Impact Factor

A portable survivorship care plan: a tool that helps educate and improve knowledge in childhood cancer survivors.

Support Care Cancer 2020 Apr 23. Epub 2020 Apr 23.

Pediatric Oncology, UCSF Benioff Children's Hospital, 550 16th Street, 4th Floor, San Francisco/Oakland, CA, 94158, USA.

Purpose: There is a growing population of survivors of childhood cancer at risk for late effects that can affect their overall quality of life. There is evidence that they have inadequate knowledge about their diagnosis, treatment, and subsequent late effects. A randomized study was conducted to determine if a portable credit card-sized plastic card, the "Survivor Healthcare Passport," improved the survivor's knowledge of diagnosis, treatment, risks, and follow-up care. Read More

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http://dx.doi.org/10.1007/s00520-020-05422-zDOI Listing

Developmental differences in health-related quality of life in adolescent and young adult cancer survivors.

Qual Life Res 2020 Apr 22. Epub 2020 Apr 22.

Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, MFRC3018, Milwaukee, WI, 53226, USA.

Purpose: Adolescents and young adults (AYAs) experience developmental transitions. AYA survivors of cancer are at risk for chronic health conditions due to treatment. This study examined developmental differences in AYA survivors' health-related quality of life (HRQOL) between age groups and compared to population norms. Read More

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http://dx.doi.org/10.1007/s11136-020-02507-4DOI Listing

Breastfeeding practices among childhood cancer survivors.

J Cancer Surviv 2020 Apr 14. Epub 2020 Apr 14.

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, USA.

Purpose: This cross-sectional study compared breastfeeding outcomes among childhood cancer survivors to those of women in the general population and evaluated whether breastfeeding is adversely affected by cancer treatment or endocrine-related late effects.

Methods: A self-reported survey ascertained breastfeeding practices and incorporated items from the questionnaires used in the Infant Feeding Practices Study II (IFPS II) to allow comparison with the general population. Among 710 eligible survivors, 472 (66%) responded. Read More

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http://dx.doi.org/10.1007/s11764-020-00882-yDOI Listing

Adolescent and Young Adult Cancer Survivors: Design and Characteristics of the First Nationwide Population-Based Cohort in Italy.

J Adolesc Young Adult Oncol 2020 Apr 13. Epub 2020 Apr 13.

Department of Research, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Adolescent and young adult (AYA, 15-39 years) cancer survivors (alive at least 5 years after cancer diagnosis) are less studied than younger and older cancer survivors and research on their late effects is limited. To facilitate research on long-term outcomes of AYA cancer survivors, we established, in Italy, a population-based AYA cancer survivors' cohort. This article describes the study design and main characteristics of this cohort. Read More

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http://dx.doi.org/10.1089/jayao.2019.0170DOI Listing

Fear of cancer recurrence among survivors of childhood cancer.

Psychooncology 2020 Apr 13. Epub 2020 Apr 13.

Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Objectives: Fear of cancer recurrence (FCR) has not been widely explored in survivors of childhood cancer. Yet, childhood survivors are at risk of experiencing late effects and may be especially vulnerable. The aims of the current study were to conduct a retrospective chart review to determine the prevalence and persistence of FCR among survivors of childhood cancer and to examine factors that may be related to FCR. Read More

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http://dx.doi.org/10.1002/pon.5387DOI Listing

Cumulative burden of subsequent neoplasms, cardiovascular and respiratory morbidity in young people surviving cancer.

Cancer Epidemiol 2020 Apr 9;66:101711. Epub 2020 Apr 9.

Clinical and Population Science Department, School of Medicine, University of Leeds, Leeds, UK; Leeds Institute for Data Analytics, University of Leeds, Leeds, UK.

Background: Long-term childhood and young adult cancer survivors are at increased risk of the late effects of multiple chronic conditions. In this study we estimate the cumulative burden of subsequent malignant neoplasms (SMN), cardiovascular and respiratory hospitalisations in long-term survivors of childhood and young adult cancers and associated treatment risks.

Methods: Five-year survivors of cancer diagnosed aged 0-29 years between 1992-2009 in Yorkshire, UK were included. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101711DOI Listing

Fertility sparing strategies for pre- and peripubertal male cancer patients.

Ecancermedicalscience 2020 27;14:1016. Epub 2020 Feb 27.

Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Genetic parenthood following cancer therapy is considered to be a major factor of quality of life. Given the rising proportion of patients surviving cancer due to improved therapeutic protocols, it is an issue of growing importance. Hence, the efforts to preserve fertility have motivated researchers to develop options for the paediatric population facing fertility-threatening cancer therapies. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105342PMC
February 2020

[Clinical features and diagnosis of secondary adrenal insufficiency followed complex treatment nonpituitary brain tumors].

Probl Endokrinol (Mosk) 2019 Nov 23;65(5):330-340. Epub 2019 Nov 23.

I.M. Sechenov First Moscow State Medical University (Sechenov University).

Background: The most of the current studies include patients who are different by the etiology of secondary adrenal insufficiency (SAI), or investigate SAI among other late effects of the radiation therapy.

Aims: To describe the features of SAI and to select the best method of screening SAI in adult patients followed complex treatment of nonpituitary brain tumors in childhood.

Materials And Methods: It was the retrospective cross-sectional study. Read More

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http://dx.doi.org/10.14341/probl10246DOI Listing
November 2019

Nationwide, population-based study of school grades in practical and aesthetic subjects of children treated for brain tumour.

BMJ Paediatr Open 2020 15;4(1):e000619. Epub 2020 Mar 15.

Department of Special Education, Stockholm University, Stockholm, Sweden.

Background: Children treated for brain tumour (hereafter termed paediatric brain tumour survivors (PBTS)) often need extra support in school because of late-appearing side effects after their treatment. We explored how this group of children perform in the five practical and aesthetic (PRAEST) subjects: home and consumer studies, physical education and health, art, crafts and music.

Methods: In this nationwide population-based study of data from the Swedish Childhood Cancer Registry and Statistics Sweden, we included 475 children born between 1988 and 1996, diagnosed with a brain tumour before their 15th birthday. Read More

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http://dx.doi.org/10.1136/bmjpo-2019-000619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073787PMC

Follow-up issues in survivors of hematologic malignancies - Current stance and future perspectives.

Blood Rev 2020 Feb 26:100674. Epub 2020 Feb 26.

Oncology Center, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia; Department of Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:

Cancer care advances have led to increased numbers of cancer survivors and to improved understanding of late effects of cancers and their therapies and survivorship issues. Long-term follow-up of cancer patients is crucial in preventing and managing many of the late effects of cancers and their therapies. However, the literature has highlighted the high rates of loss to follow-up (loss to FU) after cancer treatment, particularly in patients with hematologic malignancies. Read More

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http://dx.doi.org/10.1016/j.blre.2020.100674DOI Listing
February 2020

Current and coming challenges in the management of the survivorship population.

Semin Oncol 2020 02 4;47(1):23-39. Epub 2020 Mar 4.

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

With the widespread adoption of multimodality treatment, 5-year survival of children diagnosed with cancer has improved dramatically in the past several decades from approximately 60% in 1970 to greater than 85% currently. As a result, there are an estimated nearly half a million long-term survivors of childhood cancer living in the United States today. However, survivors have, on average, significantly greater serious medical and psychosocial late effects compared with the general population. Read More

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http://dx.doi.org/10.1053/j.seminoncol.2020.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227387PMC
February 2020

A study of childhood cancer survivors' engagement with long-term follow-up care: 'To attend or not to attend, that is the question'.

Eur J Oncol Nurs 2020 Apr 10;45:101728. Epub 2020 Feb 10.

Faculty of Health and Social Care, Edge Hill University, Ormskirk, Lancashire, L39 4QP, UK. Electronic address:

Purpose: In the UK, there are over 40,000 childhood cancer survivors (CCS); this figure grows approximately 1300 annually. Two-thirds are at risk of developing serious disabling or life-threatening conditions due to adverse late effects of the cancer or treatment received in childhood. Life-long, follow-up care for the surveillance and management of late effects is recommended. Read More

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http://dx.doi.org/10.1016/j.ejon.2020.101728DOI Listing

Early markers of cardiovascular injury in childhood leukaemia survivors treated with anthracycline chemotherapy.

Cardiooncology 2019 14;5:11. Epub 2019 Aug 14.

1School of Human Sciences: Exercise and Sport Science, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009 Australia.

Background: Cardiovascular disease (CVD) is the leading non-malignant cause of death in childhood cancer survivors. Heightened risk of CVD is often attributable to treatment with anthracycline chemotherapy. Anthracycline-mediated cardiac injury may lie latent for years following cessation of treatment and is therefore often not detected until disease is advanced and aggressive therapy is required. Read More

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http://dx.doi.org/10.1186/s40959-019-0047-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048057PMC

Summer sun-exposure in Australian childhood cancer survivors and community reference groups.

Semin Oncol 2020 02 22;47(1):48-55. Epub 2020 Feb 22.

Behavioural Sciences Unit, Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia; School of Women's and Children's Health, UNSW Sydney, Kensington, New South Wales, Australia.

Purpose: Sun-exposure can cause health problems, including melanoma and nonmelanoma skin cancer, especially in Australia where the incidence of skin cancer is particularly high. Childhood cancer survivors (CCSs) have an augmented risk due to previous cancer history and treatment. Despite recommendations advising sun protection, CCSs may be placing themselves at risk. Read More

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http://dx.doi.org/10.1053/j.seminoncol.2020.02.004DOI Listing
February 2020

Adherence to Surveillance for Second Malignant Neoplasms and Cardiac Dysfunction in Childhood Cancer Survivors: A Childhood Cancer Survivor Study.

J Clin Oncol 2020 May 6;38(15):1711-1722. Epub 2020 Mar 6.

The Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: To evaluate childhood cancer survivors' adherence to surveillance protocols for late effects of treatment and to determine the factors affecting adherence.

Methods: Between 2014 and 2016, 11,337 survivors and 2,146 siblings in the Childhood Cancer Survivor Study completed a survey ascertaining adherence to Children's Oncology Group (COG) guidelines for survivors at high risk for second malignant neoplasms or cardiac dysfunction and to the American Cancer Society (ACS) cancer screening guidelines for average-risk populations. Adherence rates and factors affecting adherence were analyzed. Read More

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http://dx.doi.org/10.1200/JCO.19.01825DOI Listing

Severe fatigue after treatment for childhood cancer.

Cochrane Database Syst Rev 2020 03 3;3:CD012681. Epub 2020 Mar 3.

Radboud University Medical Center, Department of Hematology, Geert Grooteplein Zuid 8, Nijmegen, Netherlands, 6500 HB.

Background: Treatment strategies for childhood cancer are improving, resulting in higher survival rates. However, the consequences of childhood cancer do not end with the successful completion of cancer treatment. Most patients will develop late effects after cessation of treatment. Read More

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http://dx.doi.org/10.1002/14651858.CD012681.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059965PMC

Aspirin ameliorates the long-term adverse effects of doxorubicin through suppression of cellular senescence.

FASEB Bioadv 2019 Sep 9;1(9):579-590. Epub 2019 Sep 9.

Department of Biochemistry College of Graduate Studies and Arizona College of Osteopathic Medicine Midwestern University Glendale AZ USA.

A number of childhood cancer survivors develop adverse, late onset side effects of earlier cancer treatments, known as the late effects of cancer therapy. As the number of survivors continues to increase, this growing population is at increased risk for a number of health-related problems. In the present study, we have examined the effect of aspirin on the late effects of chemotherapy by treating juvenile mice with doxorubicin (DOX). Read More

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http://dx.doi.org/10.1096/fba.2019-00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996307PMC
September 2019

Educational Intervention to Address Infertility-Related Knowledge Gaps Among Adolescent and Young Adult Survivors of Childhood Cancer.

J Adolesc Young Adult Oncol 2020 Feb 18. Epub 2020 Feb 18.

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.

This study evaluates the impact of a personalized educational session on survivors' knowledge of risk for infertility and describes preferences for reproductive health care. This was a two-phase prospective study of an individualized education session for adolescent and young adult (AYA) survivors aged 18-21 years. Sessions used sex-specific visual aids (phase I) or a personalized handout (phase II). Read More

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http://dx.doi.org/10.1089/jayao.2019.0156DOI Listing
February 2020

Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study.

Lancet Oncol 2020 Mar 14;21(3):421-435. Epub 2020 Feb 14.

Department of Pediatrics, University of Chicago, Chicago, IL, USA. Electronic address:

Background: Treatment outcomes among survivors of cancer diagnosed during adolescence and early young adulthood have not been characterised independently of survivors of cancers diagnosed during childhood. We aimed to describe chronic health conditions and all-cause and cause-specific mortality among survivors of early-adolescent and young adult cancer.

Methods: The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort study with longitudinal follow-up of 5-year survivors diagnosed with cancer before the age of 21 years at 27 academic institutions in the USA and Canada between 1970 and 1999. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30800-9DOI Listing

Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE/PBMTC 1202 studies.

Blood 2020 Apr;135(15):1287-1298

CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada.

Human graft-versus-host disease (GVHD) biology beyond 3 months after hematopoietic stem cell transplantation (HSCT) is complex. The Applied Biomarker in Late Effects of Childhood Cancer study (ABLE/PBMTC1202, NCT02067832) evaluated the immune profiles in chronic GVHD (cGVHD) and late acute GVHD (L-aGVHD). Peripheral blood immune cell and plasma markers were analyzed at day 100 post-HSCT and correlated with GVHD diagnosed according to the National Institutes of Health consensus criteria (NIH-CC) for cGVHD. Read More

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http://dx.doi.org/10.1182/blood.2019003186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146024PMC

Ultrasound is superior to palpation for thyroid cancer detection in high-risk childhood cancer and BMT survivors.

Support Care Cancer 2020 Feb 11. Epub 2020 Feb 11.

Center for Cancer and Blood Disorders, Phoenix Children's Hospital, 1919 E Thomas Road, Phoenix, AZ, 85016, USA.

Purpose: Thyroid cancer is a common subsequent malignant neoplasm in childhood cancer survivors (CCS). Patients who received radiotherapy (RT) to the head, neck, upper thorax, or total body irradiation (TBI) are considered to be at risk for subsequent thyroid cancer. Current Children's Oncology Group screening guidelines recommend annual neck palpation. Read More

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http://dx.doi.org/10.1007/s00520-020-05340-0DOI Listing
February 2020

Low bone mineral density is associated with hypogonadism and cranial irradiation in male childhood cancer survivors.

Osteoporos Int 2020 Feb 1. Epub 2020 Feb 1.

Molecular Reproductive Medicine Unit, Department of Translational Medicine, Lund University, CRC Building 91, Plan 10, Jan Waldenströms Gata 35, SE-205 02, Malmö, Sweden.

We investigated if bone mineral density was related to testosterone deficiency and/or previous cancer treatment in men who were childhood cancer survivors. Men with untreated testosterone deficiency or previous treatment with cranial irradiation were at increased risk of impaired bone health. Prevention of osteoporosis should be considered in their follow-up. Read More

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http://dx.doi.org/10.1007/s00198-020-05285-4DOI Listing
February 2020

Nutritional concerns of survivors of childhood cancer: A "First World" perspective.

Pediatr Blood Cancer 2020 Jan 29:e28193. Epub 2020 Jan 29.

Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, UNSW Sydney, Randwick, New South Wales, Australia.

Childhood cancer survivor (CCS) numbers are increasing as a result of advances in both treatment and supportive care. This positive outcome is tempered by the recognition of a high burden of chronic health conditions. Here, we review the nutritional concerns of CCS, including dietary habits after treatment and the factors during treatment that may contribute to chronic health conditions. Read More

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http://dx.doi.org/10.1002/pbc.28193DOI Listing
January 2020

Oral and dental considerations in pediatric cancers.

Cancer Metastasis Rev 2020 Mar;39(1):43-53

Hemophilia Treatment Center, Mississippi Center for Advanced Medicine, 2053 Gause Blvd, East - Ste 200, Slidell, LA, 70461, USA.

Oral health care is an integral component of interprofessional collaborative care for children and adolescents diagnosed with cancer. The current review highlights the phases of cancer therapy when dental interventions and palliative care are necessary for children diagnosed with cancer. Contemporary research and review articles pertinent to the oral and dental complications during pediatric cancer therapy and late effects in pediatric cancer survivors were identified by PubMed/MEDLINE search. Read More

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http://dx.doi.org/10.1007/s10555-020-09842-5DOI Listing

Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.

Cancer Metastasis Rev 2020 Mar;39(1):211-233

2nd Department of Pediatrics and Department of Bioinformatics, Semmelweis University, Budapest, Hungary.

Medulloblastoma (MB) is the most common malignant childhood tumor of the brain. Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced cumulative incidence of late mortality but increased the incidence of subsequent neoplasms and severe, incapacitating chronic health conditions. Present treatment strategies fail to recognize heterogeneity within patients despite wide divergence in individual responses. Read More

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http://dx.doi.org/10.1007/s10555-020-09854-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098941PMC

Pediatric surgical oncology: A brief overview of where we have been and the challenges we face.

Semin Pediatr Surg 2019 Dec 20;28(6):150864. Epub 2019 Nov 20.

Surgeon-in-Chief, Senior Vice President Surgical Services, Cincinnati Children's Hospital, MLC 2023, 3333 Burnet Ave Cincinnati, OH 54229. Electronic address:

The evolution of the treatment of pediatric solid tumors has been one of progressive improvements in survival. With the advent of pediatric cooperative groups, a systematic approach has brought integrated multidisciplinary care to childhood cancer patients. Improved medical regimens and advances in the basic understanding and characterization of molecular biology of individual tumors continues to bring new treatment options. Read More

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http://dx.doi.org/10.1016/j.sempedsurg.2019.150864DOI Listing
December 2019

Guidelines for Long-Term Follow-Up after Childhood Cancer: Practical Implications for the Daily Work.

Oncol Res Treat 2020 13;43(3):61-69. Epub 2020 Jan 13.

Pediatric Hematology and Oncology, University Hospital of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany,

Background: Many childhood cancer survivors develop treatment-associated late effects emerging years or even decades after the end of treatment. Evidence-based guidelines recommend risk-adapted screening, facilitating early diagnosis and management of these sequelae. Long-term follow-up (LTFU) in specialized late effects clinics is devised to implement screening recommendations in the care of childhood cancer survivors. Read More

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http://dx.doi.org/10.1159/000504200DOI Listing
January 2020

Cost of survivorship care and adherence to screening-aligning the priorities of health care systems and survivors.

Transl Behav Med 2020 Jan 7. Epub 2020 Jan 7.

Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY, USA.

Childhood cancer survivors (CCS) experience significant morbidity due to treatment- related late effects and benefit from late-effects surveillance. Adherence to screening recommendations is suboptimal. Survivorship care programs often struggle with resource limitations and may benefit from understanding institution-level financial outcomes associated with patient adherence to justify programmatic development and growth. Read More

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http://dx.doi.org/10.1093/tbm/ibz182DOI Listing
January 2020

The experience of hearing loss in adult survivors of childhood and young adult cancer: A qualitative study.

Cancer 2020 Apr 3;126(8):1776-1783. Epub 2020 Jan 3.

Adult Long-Term Follow-Up Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Hearing loss is a prevalent late effect among cancer survivors. Despite the significant social costs, there is a noted delay in seeking care and to the authors' knowledge there are limited data regarding the lived experiences of cancer survivors with hearing loss. The objective of the current study was to explore the lived experience of hearing loss in survivors of childhood and young adult cancers to guide survivorship care. Read More

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http://dx.doi.org/10.1002/cncr.32698DOI Listing

Life Expectancy of Adult Survivors of Childhood Cancer Over 3 Decades.

JAMA Oncol 2020 Jan 2. Epub 2020 Jan 2.

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

Importance: Advances in childhood and adolescent cancer treatment have been associated with increased rates of cure during the past 3 decades; however, improvement in adult life expectancy for these individuals has not yet been reported.

Objectives: To project long-term survival and assess whether life expectancy will improve among adult survivors of childhood cancer who were treated in more recent decades.

Design, Setting, And Participants: A microsimulation model of competing mortality risks was developed using data from the Childhood Cancer Survivor Study on 5-year survivors of childhood cancer diagnosed between 1970 and 1999. Read More

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http://dx.doi.org/10.1001/jamaoncol.2019.5582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990848PMC
January 2020

Nurse-led video-coaching interventions in childhood, adolescent and young adult cancer survivors (REVIVER): a protocol for mixed methods feasibility research.

Pilot Feasibility Stud 2019 18;5:150. Epub 2019 Dec 18.

1Centre of Expertise for Cancer Survivorship, Department of Haematology, Radboud University Medical Centre, Geert Grooteplein Zuid 10 (Route 558), 6525 GA Nijmegen, NL Netherlands.

Background: Successful cancer treatment can lead to cancer survivors being predisposed to an increased lifelong risk of adverse late health effects. Therefore, high-quality cancer survivorship care to earlier detect and treat late effects or to preserve survivor's health is essential. Nevertheless, this care needs to be sustainable and cost-effective as well. Read More

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http://dx.doi.org/10.1186/s40814-019-0535-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921525PMC
December 2019

Changes in neurocognitive function and central nervous system structure in childhood acute lymphoblastic leukaemia survivors after treatment: a meta-analysis.

Br J Haematol 2020 Mar 10;188(6):945-961. Epub 2019 Dec 10.

Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, Shandong, China.

Acute lymphoblastic leukaemia (ALL) is the most common malignancy in children. Although the survival rate has increased dramatically over the last decades, patients struggle with the adverse side effects of treatment. Treatment for ALL includes chemotherapy and irradiation - both of which are linked to cognitive impairments and alterations in central nervous system (CNS) structure and function detected by neuroimaging and in neurocognitive studies. Read More

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http://dx.doi.org/10.1111/bjh.16279DOI Listing

Advanced glycation end products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation.

Pediatr Blood Cancer 2020 03 9;67(3):e28106. Epub 2019 Dec 9.

Transition Unit for Childhood Cancer Survivors, Città della Salute e della Scienza Hospital, Turin, Italy.

Background: Among survivors of pediatric acute lymphoblastic leukemia (ALL), those who received hematopoietic stem cell transplantation (HSCT) conditioned with total-body irradiation (TBI) show the highest risk of late complications, including cardiovascular (CV) disease. Advanced glycation end products (AGEs) have been associated with CV disease in diabetes mellitus and other clinical conditions. This study explores AGEs plasma levels, inflammatory status, and lipid profile in survivors of pediatric ALL who received HSCT conditioned with TBI. Read More

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http://dx.doi.org/10.1002/pbc.28106DOI Listing

Cardiotoxicity among adult survivors suffered from childhood malignancies.

Hell J Nucl Med 2019 Sep-Dec;22 Suppl 2:34-40

CICU, NUCU, PICU/Great Ormond Street Hospital, London, UK.

Late cardiotoxicity following treatment of malignancy diseases has been long established. Cancer therapeutics-related cardiac dysfunction (CTRCD), acute arrhythmias, pericardial disease, valvopathies and early atherosclerotic Cardiovascular Disease (CVD), are the clinical presentations of cardiotoxicity. Although these clinical modalities can affect adults treated for malignancies, they are more common to present in the pediatric survivors as improvement of prognosis, nowadays exists. Read More

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Comparison of Radiation Dose Reconstruction Methods to Investigate Late Adverse Effects of Radiotherapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

Radiat Res 2020 02 3;193(2):95-106. Epub 2019 Dec 3.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Quantification of radiation dose to normal tissue during radiotherapy is critical for assessing risk for radiotherapy-related late effects, including subsequent neoplasms (SNs). Case-control studies of SNs typically reconstruct absorbed radiation dose to the specific SN location using individual treatment parameters. A simplified method estimates the maximum prescribed target dose to the body region in which the SN arises. Read More

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http://dx.doi.org/10.1667/RR15308.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063664PMC
February 2020

Advances in pediatric psychooncology.

Curr Opin Pediatr 2020 Feb;32(1):41-47

Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC, USA.

Purpose Of Review: This article reviews the current literature on psychosocial care of children with cancer with particular focus on evidence-based standards of care, including developments in systematic distress screening, utilization of patient-reported outcomes, evidence-based interventions, survivorship, palliative care and bereavement.

Recent Findings: Although attention to the psychosocial needs of the child and family is increasingly recognized as an essential element of care for children with cancer, implementing evidence-based care remains suboptimal. Recent efforts have focused on utilizing technology to improve the reach of these interventions and to enhance engagement with special populations, such as adolescents and young adults. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117751PMC
February 2020

Upfront Therapies and Downstream Effects: Navigating Late Effects in Childhood Cancer Survivors in the Current Era.

Curr Oncol Rep 2019 11 25;21(12):104. Epub 2019 Nov 25.

Seattle Children's Hospital/University of Washington, 1100 Fairview Ave N, D5-390, Seattle, WA, 98109, USA.

Purpose Of Review: As survival rates of those diagnosed with childhood cancer improve over time, the number of long-term survivors continues to grow. Advances have not only been made in the upfront treatment of childhood cancer, but also in the identification and treatment of late complications that may arise as a result of the chemotherapy, radiotherapy, or surgical interventions required to provide a cure.

Recent Findings: As new therapies emerge that are often more targeted to cancerous cells while sparing healthy tissues, the hope is that cure can be achieved without the same long-term side effects for survivors. Read More

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http://dx.doi.org/10.1007/s11912-019-0861-8DOI Listing
November 2019

Quality of survival assessment in European childhood brain tumour trials, for children below the age of 5 years.

Eur J Paediatr Neurol 2020 Mar 25;25:59-67. Epub 2019 Oct 25.

Rehabilitation Department, Outreach Team for Children and Adolescents with Acquired Brain Injury, Saint-Maurice Hospitals, 14 Rue du Val d'Osne, 94410 Saint-Maurice, France; Sorbonne Université, Laboratoire d'Imagerie Biomédicale, LIB, 75006 Paris, France.

The highest incidence rate of childhood brain tumours is in children below the age of five years, who are particularly vulnerable to the effects of treatments. The assessment of quality of survival (QoS) in multiple domains is essential to compare the outcomes for different tumour types and treatment regimens. The aim of this position statement is to present the domains of health and functioning to be assessed in children from birth to five years, to advance the collection of a common QoS data set in European brain tumour trials. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.10.002DOI Listing