3,612 results match your criteria Lasers in Surgery and Medicine [Journal]


Lasers and energy-based devices marketed for vaginal rejuvenation: A cross-sectional analysis of the MAUDE database.

Lasers Surg Med 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology, University of California, San Diego School of Medicine, 9500 Gillman Drive, La Jolla 92093, California.

Introduction: The FDA issued a statement on July 30, 2018, expressing concern over the marketing of lasers and energy-based devices to promote "vaginal rejuvenation." The FDA stated that there is insufficient data to recommend this modality for optimization of sexual function and alleviation of genitourinary syndrome of menopause (GSM)-related symptoms in postmenopausal or postpartum women. This analysis aims to characterize the mandatory and voluntary reports concerning laser and energy-based procedures marketed for vaginal rejuvenation. Read More

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http://dx.doi.org/10.1002/lsm.23084DOI Listing
March 2019
1 Read

Propionibacterium acnes susceptibility to low-level 449 nm blue light photobiomodulation.

Lasers Surg Med 2019 Mar 28. Epub 2019 Mar 28.

The Johnson and Johnson Skin Research Center, Johnson and Johnson Consumer Inc. Skillman, Skillman, New Jersey.

Background And Objective: Recent advances in low-level light devices have opened new treatment options for mild to moderate acne patients. Light therapies have been used to treat a variety of skin conditions over the years but were typically only available as treatments provided by professional clinicians. Clinical application of blue light has proven to be effective for a broader spectral range and at lower fluences than previously utilized. Read More

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http://dx.doi.org/10.1002/lsm.23087DOI Listing

Grading upper tract urothelial carcinoma with the attenuation coefficient of in-vivo optical coherence tomography.

Lasers Surg Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Urology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Introduction: With catheter based optical coherence tomography (OCT), high resolution images of the upper urinary tract can be obtained, thereby facilitating the detection of upper tract urothelial carcinomas (UTUC). We hypothesized that the attenuation coefficient of the OCT signal (μ ) is related to the histopathologic grade of the tumor.

Objectives: In this study, we aimed to define the μ cut-off for discriminating high grade and low grade papillary UTUC. Read More

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http://dx.doi.org/10.1002/lsm.23079DOI Listing

Drug penetration enhancement techniques in ablative fractional laser assisted cutaneous delivery of indocyanine green.

Lasers Surg Med 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, NL-1105 AZ, Amsterdam, The Netherlands.

Background And Objectives: Topical drug delivery can be increased by pretreatment of the skin with ablative fractional laser (AFXL). Several physical penetration enhancement techniques have been investigated to further improve AFXL-assisted drug delivery. This study investigated the influence of three of these techniques, namely massage, acoustic pressure wave treatment, and pressure vacuum alterations (PVP) on the distribution of the fluorescent drug indocyanine green (ICG) at different depths in the skin after topical application on AFXL pretreated skin. Read More

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http://dx.doi.org/10.1002/lsm.23088DOI Listing

Dose-response of human follicles during laser-based hair removal: Ex vivo photoepilation model with classification system embracing morphological and histological features.

Lasers Surg Med 2019 Mar 19. Epub 2019 Mar 19.

Philips Research, High Tech Campus 11, 5656 AE, Eindhoven, The Netherlands.

Objectives: Photoepilation is a commonly used technology in home-use devices (HUDs) and in professional systems to remove unwanted body hair using pulses of laser or intense pulsed light (IPL). Albeit HUDs and professional systems operate at different fluences and treatment regimes, both demonstrate high hair reduction. The underlying mechanisms, however, remain unknown partly due to high divergence of the existing literature data. Read More

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http://dx.doi.org/10.1002/lsm.23085DOI Listing

Society Update.

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Lasers Surg Med 2019 Mar;51(3):309-310

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http://dx.doi.org/10.1002/lsm.22966DOI Listing
March 2019
1 Read

American Society for Laser Medicine and Surgery 2019 Electronic Posters (ePosters).

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Lasers Surg Med 2019 Mar;51(S31):S16-S31

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http://dx.doi.org/10.1002/lsm.23068DOI Listing

American Society for Laser Medicine and Surgery 2019 Late Breaking Abstracts.

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Lasers Surg Med 2019 Mar;51(S31):S4-S15

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http://dx.doi.org/10.1002/lsm.23067DOI Listing
March 2019
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The effect of melanin on in vivo optical coherence tomography of the skin in a multiethnic cohort.

Lasers Surg Med 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, University of California, Irvine, 92697, California.

Background: Noninvasive real-time assessment of living tissue is quickly becoming invaluable for bolstering histologic and dermatoscopic measures of cutaneous conditions. While many skin researchers have explored the utility of noninvasive imaging in inflammatory and malignant skin conditions, there is yet to be a definitive and direct assessment of the effects of melanin on the quality of optical coherence tomography (OCT) imaging and its accuracy in multiethnic patient populations. We conducted a study to evaluate the effects of melanin on the quality of in vivo OCT imaging. Read More

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http://dx.doi.org/10.1002/lsm.23086DOI Listing
March 2019
3 Reads

Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser.

Lasers Surg Med 2019 Mar 18. Epub 2019 Mar 18.

Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: The effectiveness of transcranial photobiomodulation (TPBM) in treating anxiety and depression disorders is a demonstrated and identified issue. However, the optimum therapeutic dose and the underlying mechanism of action are not fully understood. In this study, the therapeutic effects of three different near-infrared (NIR) doses on anxiety- and depression-like behaviors as well as cerebral levels of serotonin (5-HT) and nitric oxide (NO) were evaluated in a mouse model of chronic restraint stress (CRS). Read More

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http://dx.doi.org/10.1002/lsm.23082DOI Listing
March 2019
1 Read
2.619 Impact Factor

Enhanced laser surface ablation with an integrated photoacoustic imaging and high intensity focused ultrasound system.

Lasers Surg Med 2019 Mar 12. Epub 2019 Mar 12.

Bioengineering Program and Institute for Bioengineering Research, University of Kansas, Lawrence, Kansas.

Background And Objective: Combined laser and ultrasound treatments have been found to have synergistic effects, which may be of particular note in dermatology. We aim to investigate the potential of this technology for dermatology through in vitro and ex vivo experiments.

Methods: In vitro tissue phantoms made of agar and tattoo ink and tattooed ex vivo chicken breast tissue were used. Read More

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http://dx.doi.org/10.1002/lsm.23072DOI Listing
March 2019
2 Reads

Predictive value of dermoscopy for the treatment of port-wine stains with large spot 532 nm laser.

Lasers Surg Med 2019 Mar 12. Epub 2019 Mar 12.

Klinika Ambroziak, Warsaw, Poland.

Objective: We wanted to evaluate dermoscopy as a tool to predict the efficacy of port-wine stain (PWS) laser treatment.

Study Design And Methods: Large spot 532 nm laser was used for the treatment of 67 PWS. Efficacy was assessed with an objective 3D digital imaging analysis. Read More

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http://dx.doi.org/10.1002/lsm.23083DOI Listing
March 2019
1 Read

Characterization of the transmission behavior of dental filling materials and cements for the diode lasers' and the Nd:YAG laser's wavelengths.

Lasers Surg Med 2019 Mar 7. Epub 2019 Mar 7.

Center of Dentistry, Department of Prosthetic Dentistry, Ulm University, Ulm, 89081, Germany.

Objectives: Diode lasers and the Nd:YAG laser are used in periodontal therapy and soft tissue surgery. Dental filling materials or cements might be inadvertently damaged. The underlying mechanism of the damage is based on the dental material's specific transmission and thus absorption behavior. Read More

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http://dx.doi.org/10.1002/lsm.23081DOI Listing
March 2019
1 Read

Quantitative proteomic analysis of dermal papilla from male androgenetic alopecia comparing before and after treatment with low-level laser therapy.

Lasers Surg Med 2019 Mar 7. Epub 2019 Mar 7.

Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Currently, low-level laser therapy (LLLT) has been approved as a new treatment for androgenetic alopecia (AGA). However, it has not been elucidated how LLLT promotes hair growth in vivo.

Objectives: To investigate the change in protein expression from dermal papilla (DP) tissues in male AGA patients after LLLT treatment using liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. Read More

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http://dx.doi.org/10.1002/lsm.23074DOI Listing
March 2019
3 Reads

Pulsed-dye laser as an adjuvant treatment for papulopustular eruptions from epidermal growth factor receptor inhibitors, a randomized blinded split-faced controlled trial.

Lasers Surg Med 2019 Mar 7. Epub 2019 Mar 7.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Skin and Allergy Research Unit, Chulalongkorn University, Bangkok, Thailand.

Objectives: To investigate the efficacy of pulsed-dye laser (PDL) as an adjunctive treatment for facial papulopustular eruptions from EGFR inhibitors (EGFRi).

Methods: Fourteen patients with facial acneiform eruptions were recruited. Half side of the face was randomized to receive PDL treatment while the other side served as a control. Read More

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http://dx.doi.org/10.1002/lsm.23080DOI Listing
March 2019
2 Reads

Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography.

Lasers Surg Med 2019 Mar 5. Epub 2019 Mar 5.

Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, DK-2400, Copenhagen, Denmark.

Introduction: Topical application of gold microparticles (GMPs) for selective photothermolysis is a recently FDA-cleared therapy for acne vulgaris. Current evidence indicates the potential of optical imaging to non-invasively visualize GMPs and describe photothermal tissue effects.

Objectives: To qualitatively and quantitatively describe GMP delivery in vivo and visualize laser-mediated thermal effects of GMPs in facial skin of acne patients and healthy participants, using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Read More

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http://dx.doi.org/10.1002/lsm.23076DOI Listing
March 2019
2 Reads

Age differences in photodynamic therapy-mediated opening of the blood-brain barrier through the optical clearing skull window in mice.

Lasers Surg Med 2019 Feb 27. Epub 2019 Feb 27.

Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Britton Chance Center for Biomedical Photonics, Wuhan, Hubei, 430074, China.

Background: Photodynamic therapy (PDT), a minimally invasive therapeutic tool, has been an important option for post-surgical treatment of malignant gliomas (MGs) in both adult and young patients. Recent studies have shown that PDT can also open the blood-brain barrier (BBB). However, there are no optimized parameters of PDT for patients at different ages. Read More

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http://dx.doi.org/10.1002/lsm.23075DOI Listing
February 2019
3 Reads
2.619 Impact Factor

Randomized, double-blind, phase III clinical study of a novel nanotechnological topical anesthetic formulation containing lidocaine 25 mg/g and prilocaine 25 mg/g (nanorap) in skin phototypes I-III patients with ablative fractional CO laser treatment indication in the forehead.

Lasers Surg Med 2019 Feb 27. Epub 2019 Feb 27.

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.

Background And Objectives: Nanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics of a novel topical anesthetic nanocapsule formulation (2 g) containing 2.5% lidocaine and 2. Read More

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http://dx.doi.org/10.1002/lsm.23071DOI Listing
February 2019
3 Reads

Clinical and histological evaluation of a single high energy microwave treatment for primary axillary hyperhidrosis in Asians: A prospective, randomized, controlled, split-area comparative trial.

Lasers Surg Med 2019 Feb 27. Epub 2019 Feb 27.

Department of Dermatology, Wakayama Medical University, Wakayama, Japan.

Background And Objectives: Microwave treatment is an effective non-invasive treatment option for primary axillary hyperhidrosis (PAH), but the treatment parameters vary and no histopathological studies have been performed to validate clinical outcomes. This study investigated its efficacy and safety and histopathological changes after a single microwave treatment at the maximum energy level for PAH in Asians.

Materials And Methods: A prospective, clinical, and histological split-area randomized controlled trial (RCT) was performed in Japan. Read More

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http://dx.doi.org/10.1002/lsm.23073DOI Listing
February 2019
1 Read

Near-infrared multispectral endoscopic imaging of deep artificial interproximal lesions in extracted teeth.

Lasers Surg Med 2019 Feb 27. Epub 2019 Feb 27.

University of Washington, Human Photonics Lab, Mechanical Engineering, 4000 Mason St, Seattle, 98195, Washington.

Background And Objective: A safer alternative method to radiographic imaging is needed. We present a multispectral near-infrared scanning fiber endoscope (nirSFE) for dental imaging which is designed to be the smallest imaging probe with near-infrared (NIR) imaging (1200-2000 nm).

Materials And Methods: The prototype nirSFE is designed for wide-field forward viewing of scanned laser illumination at 1310, 1460, or 1550 nm. Read More

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http://dx.doi.org/10.1002/lsm.23065DOI Listing
February 2019
1 Read

Society Update.

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Lasers Surg Med 2019 Feb;51(2):208-209

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http://dx.doi.org/10.1002/lsm.22963DOI Listing
February 2019
1 Read

American Society for Laser Medicine and Surgery Abstracts.

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Lasers Surg Med 2019 Feb;51(S30):S4-S59

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http://doi.wiley.com/10.1002/lsm.23059
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http://dx.doi.org/10.1002/lsm.23059DOI Listing
February 2019
10 Reads

Stereotaxic laser brain surgery with 1940-nm Tm:fiber laser: An in vivo study.

Lasers Surg Med 2019 Feb 19. Epub 2019 Feb 19.

Biophotonics Laboratory, Institute of Biomedical Engineering, Bogazici University, Kandilli Campus, Cengelkoy, Istanbul, 34684, Turkey.

Background: With exciting developments in fiber laser technology, studies investigating the use of lasers in neurosurgery have been increasing in the recent years. Fiber lasers are advantageous in many ways; first of all they are compact and they provide a more comfortable environment in the operating room due to feasibility of coupling laser light to different cross-sectioned fibers. Thulium fiber (Tm:fiber) lasers have been under investigation for medical applications since 2005 due to their spectral proximity to the water absorption peak. Read More

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http://dx.doi.org/10.1002/lsm.23070DOI Listing
February 2019
2 Reads

Vascular-targeted low dose photodynamic therapy stabilizes tumor vessels by modulating pericyte contractility.

Lasers Surg Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Thoracic Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still debated. In pericyte and endothelial cell co-cultures, we show that pericytes exhibit enhanced sensitivity towards L-PDT compared to endothelial cells, displaying actin stress fibers and cellular contraction via Rho/ROCK kinase signaling myosin light chain and focal adhesion kinase phosphorylation (MLC-P, FAK-P). Read More

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http://dx.doi.org/10.1002/lsm.23069DOI Listing
February 2019
4 Reads

Efficacy of fractional CO laser in the treatment of genitourinary syndrome of menopause in Latin-American Population: First Peruvian experience.

Lasers Surg Med 2019 Feb 19. Epub 2019 Feb 19.

Universidad Del Valle, Cali, Colombia.

Objective: This PUBA study aimed to assess the efficacy of fractional CO2 laser in the treatment of genitourinary syndrome of menopause (GSM).

Methods: GSM symptoms were assessed before, 1 month after the first session and 1 month after the third session of laser (3 sessions with a 30 days interval between them) in 60 women (median, interquartile range: 55, 49-69). Subjective (visual analog scale) and objective (Vaginal Health Index, VHIS; Vaginal Maturity Index/Frost Index; Spanish Overactive Bladder Questionnaire-Short Form, USMEX Spanish OAB-qSF and Female Sexual Function Index, FSFI) measures were used during the study period to assess CO2 fractionated laser treatment outcomes compared to baseline. Read More

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http://doi.wiley.com/10.1002/lsm.23066
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http://dx.doi.org/10.1002/lsm.23066DOI Listing
February 2019
7 Reads

Sound levels and safety in cosmetic laser surgery.

Lasers Surg Med 2019 Feb 1. Epub 2019 Feb 1.

SkinCare Physicians, 1244 Boylston Street, Suite 103, Chestnut Hill, Massachusetts, 02467.

Objectives: Measure the sound levels produced by various lasers commonly used during routine outpatient cosmetic surgery to determine whether or not their use exceeds exposure levels set forth by the US National Institute for Occupational Safety and Health (NIOSH) and the US Occupational Safety and Health Administration (OSHA).

Materials And Methods: Using two different meters, the sound levels of lasers commonly used in cosmetic surgery were recorded during various procedures for several indications: tattoo removal, treatment of lentigines and pigmented lesions, facial erythema and vascular lesions, hair removal and resurfacing of acne scars, and photoaging.

Results: All but five lasers had a maximum sound level below 85 dBA, the limit proposed by NIOSH. Read More

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http://dx.doi.org/10.1002/lsm.23062DOI Listing
February 2019
3 Reads

Needle-free pneumatic injection device; histologic assessment using a rat model and parameter comparison in predicting collagen synthesis degree.

Lasers Surg Med 2019 Mar 1;51(3):278-285. Epub 2019 Feb 1.

Department of Dermatology, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, Korea.

Background: Needle-free pneumatic injections have been recently introduced to the field of dermatology to inject such substances as hyaluronic acid. However, data on the influence of various pneumatic injection parameters on collagen synthesis are lacking.

Objective: Compare the effect of diameter, pressure, and volume of a pneumatic injection jet on collagen synthesis and fluid dispersion pattern using a rat model. Read More

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http://dx.doi.org/10.1002/lsm.23046DOI Listing
March 2019
1 Read

Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap.

Lasers Surg Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Plastic Reconstructive and Aesthetic Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: The aim of this study was to evaluate the effect of relatively novel approach of application of polychromatic light waves on flap survival of experimental musculocutaneous flap model and to investigate efficacy of this modality as a delay procedure to increase vascularization of zone 4 of transverse rectus abdominis musculocutaneous (TRAM) flap.

Methods: Twenty-one Wistar rats were randomized and divided into 3 experimental groups (n = 7 each). In group 1 (control group), after being raised, the TRAM flap was sutured back to its bed without any further intervention. Read More

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http://doi.wiley.com/10.1002/lsm.23063
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http://dx.doi.org/10.1002/lsm.23063DOI Listing
February 2019
9 Reads

Light-based home-use devices for hair removal: Why do they work and how effective they are?

Lasers Surg Med 2019 Jan 25. Epub 2019 Jan 25.

Skinperium, Luxembourg, Europe.

Objectives: This review has the following objectives: Firstly, it provides an explanation of the evolution of laser/intense pulsed light (IPL) hair reduction modalities from high fluence professional devices to low fluence home-use appliances. Secondly, it summarises published literature reviews on home-use devices (HUDs) as evidence of their growing credibility. Thirdly, it proposes mechanistic differences in light delivery regimes and the resulting divergences in mode of action. Read More

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http://dx.doi.org/10.1002/lsm.23061DOI Listing
January 2019
12 Reads

Computational analysis of six optical coherence tomography systems for vocal fold imaging: A comparison study.

Lasers Surg Med 2019 Jan 25. Epub 2019 Jan 25.

Beckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, California, 92612.

Objectives: There have been many advancements in laryngeal imaging using optical coherence tomography (OCT), with varying system design and probes for use in research, office, and operating room settings. We evaluated the performance of six distinct OCT systems in imaging porcine vocal folds (cords) using computational image processing and segmentation.

Methods: Porcine vocal folds were scanned using six OCT systems. Read More

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http://dx.doi.org/10.1002/lsm.23060DOI Listing
January 2019
2.619 Impact Factor

Comparison of 311-nm Titanium:Sapphire laser and 308-nm excimer laser treatment for vitiligo: A randomized controlled non-inferiority trial.

Lasers Surg Med 2019 Mar 25;51(3):239-244. Epub 2019 Jan 25.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

Objectives: The 308-nm excimer laser (EL) has been widely used for localized vitiligo. The recently developed Titanium:Sapphire laser, emits a wavelength of 311 nm, would be expected to be as effective as excimer laser in treatment of vitiligo but few controlled trials have been reported. We sought to compare the efficacy and safety of the TSL and EL as vitiligo treatments. Read More

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http://dx.doi.org/10.1002/lsm.23048DOI Listing

Efficacy and safety of intense pulsed light with a KTP filter for the treatment of solar lentigines.

Lasers Surg Med 2019 Jan 25. Epub 2019 Jan 25.

The Pearl Dermatology, Houston, Texas.

Background: Optical energy-based devices, including intense pulsed light (IPL) and potassium titanyl phosphate (KTP) lasers achieve reduction of pigmented and vascular lesions in a relatively similar number of treatments. This study aimed to evaluate the efficacy and safety of an IPL with a "KTP-like" filter emitting a wavelength of 525-585 nm for the treatment of solar lentigines on the hands and face.

Methods: This was a single center, prospective, open-label clinical trial including 16 healthy Caucasian subjects (15 females, mean age, 55 years; skin types II and III) with hand and facial solar lentigines. Read More

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http://dx.doi.org/10.1002/lsm.23056DOI Listing
January 2019
3 Reads

Patient satisfaction and our clinical experience with 459 microfocused ultrasound treatments.

Lasers Surg Med 2019 Jan 21. Epub 2019 Jan 21.

Union Square Laser Dermatology, 19 Union Square West, 5th Floor, New York, New York.

Purpose: Microfocused ultrasound (MFUS) is a safe and effective method for noninvasive skin tightening. Previous clinical studies demonstrate a 60-100% patient satisfaction after MFUS. We used an anonymous online platform after MFUS to assess patient satisfaction. Read More

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http://dx.doi.org/10.1002/lsm.23058DOI Listing
January 2019
2 Reads

Hyperspectral imaging in automated digital dermoscopy screening for melanoma.

Lasers Surg Med 2019 Mar 17;51(3):214-222. Epub 2019 Jan 17.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York.

Objectives: Early melanoma detection decreases morbidity and mortality. Early detection classically involves dermoscopy to identify suspicious lesions for which biopsy is indicated. Biopsy and histological examination then diagnose benign nevi, atypical nevi, or cancerous growths. Read More

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http://doi.wiley.com/10.1002/lsm.23055
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http://dx.doi.org/10.1002/lsm.23055DOI Listing
March 2019
42 Reads

Society Update.

Authors:

Lasers Surg Med 2019 Jan;51(1):114-115

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http://dx.doi.org/10.1002/lsm.22959DOI Listing
January 2019

High power holmium:YAG versus thulium fiber laser treatment of kidney stones in dusting mode: ablation rate and fragment size studies.

Lasers Surg Med 2019 Jan 16. Epub 2019 Jan 16.

Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina.

Objectives: The experimental Thulium fiber laser (TFL) is currently being studied as a potential alternative to the gold standard Holmium:YAG laser for lithotripsy. Recent advances in both Holmium and TFL technology allow operation at similar laser parameters for direct comparison. The use of a "dusting" mode with low pulse energy (0. Read More

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http://dx.doi.org/10.1002/lsm.23057DOI Listing
January 2019
4 Reads

Improved MR thermometry for laser interstitial thermotherapy.

Lasers Surg Med 2019 Mar 15;51(3):286-300. Epub 2019 Jan 15.

Utah Center for Advanced Imaging Research, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah.

Objectives: To develop, test and evaluate improved 2D and 3D protocols for proton resonance frequency shift magnetic resonance temperature imaging (MRTI) of laser interstitial thermal therapy (LITT). The objective was to develop improved MRTI protocols in terms of temperature measurement precision and volume coverage compared to the 2D MRTI protocol currently used with a commercially available LITT system.

Methods: Four different 2D protocols and four different 3D protocols were investigated. Read More

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http://dx.doi.org/10.1002/lsm.23049DOI Listing

Comparison of an Er: YAG laser osteotome versus a conventional drill for the use in osteo- odonto-keratoprosthesis (OOKP).

Lasers Surg Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Ophthalmology, University Hospital Basel, University Basel, Basel, Switzerland.

Objectives: The osteo-odonto-kerato-prosthesis (OOKP) procedure is a complex, multi-stage, multidisciplinary surgical intervention for the treatment of severe corneal blindness. One step of the OOKP consists of creating a precise hole into a tooth in which an optic cylinder is subsequently inserted; its shape must ensure a perfect watertight fit. The Er: YAG laser (L) used in this study is part of CARLO®, the first laser osteotome that enables surgical planning based on computed tomography data, robot guidance, and a precise execution of laser cuts in teeth and bone tissue, using laser photoablation rather than conventional mechanical methods. Read More

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http://dx.doi.org/10.1002/lsm.23053DOI Listing
January 2019
4 Reads

Decreased phototoxicity of photodynamic therapy by Cx32/Cx26-composed GJIC: A "Good Samaritan" effect.

Lasers Surg Med 2019 Mar 7;51(3):301-308. Epub 2019 Jan 7.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Pharmacy School of Xuzhou Medical University, Xuzhou City 221004, Jiangsu Province, P. R. China.

Background And Objective: Photodynamic therapy (PDT) has been widely used to treat malignant tumors. Our previous studies indicated that connexin (Cx) 32- and Cx26-composed gap junctional intercellular communication (GJIC) could improve the phototoxicity of PDT. However, the role of heterotypic Cx32/Cx26-formed GJIC in PDT phototoxicity is still unknown. Read More

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http://dx.doi.org/10.1002/lsm.23044DOI Listing
March 2019
3 Reads

A miniaturized, tethered, spectrally-encoded confocal endomicroscopy capsule.

Lasers Surg Med 2019 Jan 6. Epub 2019 Jan 6.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, Massachusetts.

Background And Objective: The tethered spectrally-encoded confocal endomicroscopy (SECM) capsule is an imaging device that once swallowed by an unsedated patient can visualize cellular morphologic changes associated with gastrointestinal (GI) tract diseases in vivo. Recently, we demonstrated a tethered SECM capsule for counting esophageal eosinophils in patients with eosinophilic esophagitis (EoE) in vivo. Yet, the current tethered SECM capsule is far too long to be widely utilized for imaging pediatric patients, who constitute a major portion of the EoE patient population. Read More

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http://dx.doi.org/10.1002/lsm.23050DOI Listing
January 2019
7 Reads

Treatment of telangiectasia on the cheeks with a compact yellow (585 nm) semiconductor laser and a green (532 nm) KTP laser: a randomized double-blinded split-face trial.

Lasers Surg Med 2019 Mar 6;51(3):223-229. Epub 2019 Jan 6.

Optoelectronics Research Centre, Tampere University of Technology (TUT), Korkeakoulunkatu 3, 33720, Tampere, Finland.

Objectives: The primary objective of this study was to compare a traditional green KTP laser to a new investigational yellow laser (PhotoLase) in the treatment of facial telangiectasia in terms of the treatment outcomes. The secondary objective was to assess the functionality and reliability of the PhotoLase system from the perspective of the user.

Study Design/methods: The study was a randomized split-face double-blinded study that compared the treatment efficacy of the 532-nm KTP laser and the investigational 585-nm PhotoLase laser. Read More

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http://dx.doi.org/10.1002/lsm.23051DOI Listing

Comparison between topical recombinant human epidermal growth factor and Aloe vera gel in combination with ablative fractional carbon dioxide laser as treatment for striae alba: A randomized double-blind trial.

Lasers Surg Med 2019 Jan 6. Epub 2019 Jan 6.

Department of Pathology and Forensic Medicine, Thammasat University, Pathumthani, Thailand.

Objectives: Striae distensae are linear atrophic dermal scars. Despite several currently available therapeutic modalities, no consistently effective therapies have been established. This study aimed to evaluate and compare the efficacy of topical recombinant human epidermal growth factor (rhEGF) and ablative fractional carbon dioxide (CO ) laser (AFXL) versus ablative fractional CO laser and topical Aloe vera gel in treating striae alba. Read More

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http://dx.doi.org/10.1002/lsm.23052DOI Listing
January 2019
2 Reads

Eradication of hairy mouth after oncological resection of the tongue and floor mouth using a diode laser 808 nm. Postoperative pain assessment using thermal infrared imaging.

Lasers Surg Med 2019 Jan 6. Epub 2019 Jan 6.

Department of Morphology, Experimental Medicine and Surgery, University of Ferrara, Ferrara, Italy.

Objectives: Vascularized soft tissue flaps are often harvested from hair-bearing areas, such as the radial forearm or anterolateral thigh, making their use in oral reconstruction problematic due to postoperative hair growth. The presence of intact hair follicles in free tissue transfer and continued hair growth at the recipient site can result in difficulties with oral hygiene, intraoral irritation, food trapping, and patient distress. This study was to evaluate the intraoral efficacy and safety of a diode laser 808 nm when used for hair removal. Read More

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http://doi.wiley.com/10.1002/lsm.23054
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http://dx.doi.org/10.1002/lsm.23054DOI Listing
January 2019
3 Reads
2.619 Impact Factor

MR-guided laser interstitial thermal therapy in the treatment of recurrent intracranial meningiomas.

Lasers Surg Med 2019 Mar 28;51(3):245-250. Epub 2018 Dec 28.

Department of Neurosurgery, Henry Ford Hospital, 2799 West Grand Blvd, Detroit 48202, Michigan.

Objective: Recurrent meningiomas can prove problematic for treatment, especially if anaplastic, as options are limited primarily to surgery and radiation therapy. Laser interstitial thermal therapy (LITT) is a minimally invasive technique for achieving immediate cytoreduction. This study seeks to determine the utility of LITT in the setting of recurrent meningiomas. Read More

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http://dx.doi.org/10.1002/lsm.23045DOI Listing
March 2019
1 Read

Transdermal delivery of water-soluble fluorescent antibody mediated by fractional Er:YAG laser for the diagnosis of lupus erythematosus in mice.

Lasers Surg Med 2019 Mar 28;51(3):268-277. Epub 2018 Dec 28.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan 430022, China.

Objectives: Although transdermal drug delivery system (TDDS) has been successfully used for delivering small molecules, its application in the delivery of diagnostic antibodies has been limited due to their large size. In this study, we aim to obtain a broad insight in the dynamics of TRITC-conjugated Goat Anti-Mouse IgG (T-IgG) uptake in fractional Er:YAG laser pretreated skin and provide a new technical option for detecting lupus erythematosus (LE) in mice.

Methods: The skins of SD and MRL/lpr mice were treated by fractional Er:YAG laser followed by external application of T-IgG. Read More

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http://doi.wiley.com/10.1002/lsm.23047
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http://dx.doi.org/10.1002/lsm.23047DOI Listing
March 2019
14 Reads

The ablative fractional coagulation zone influences skin fluorescence intensities of topically applied test molecules-An in vitro study with fluorescence microscopy and fluorescence confocal microscopy.

Lasers Surg Med 2019 Jan 25;51(1):68-78. Epub 2018 Dec 25.

Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, 2400, Copenhagen NV, Denmark.

Background: Ablative fractional laser (AFL) increases uptake of topically applied skin agents. The coagulation zone (CZ) surrounding vertically ablated channels may influence uptake of drugs.

Objectives: To investigate impact of CZ thickness on skin fluorescence intensities (FI) of a hydrophilic molecule by means of fluorescence microscopy (FM) and fluorescence confocal microscopy (FCM). Read More

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http://dx.doi.org/10.1002/lsm.23034DOI Listing
January 2019

Efficacy of noninvasive multisource radiofrequency treatment on periorbital rhytids using an imaging device.

Lasers Surg Med 2019 Mar 21;51(3):251-255. Epub 2018 Dec 21.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Objective: To evaluate the efficacy of the multisource radiofrequency in periorbital wrinkles treatment using a VISIA imager.

Methods: This is a prospective cohort study involving 30 sites in 15 patients.

Inclusion Criteria: healthy subjects with periorbital wrinkles. Read More

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http://doi.wiley.com/10.1002/lsm.23038
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http://dx.doi.org/10.1002/lsm.23038DOI Listing
March 2019
4 Reads

Discrimination of cancerous and healthy colon tissues: A new laser-based method.

Lasers Surg Med 2019 Apr 21;51(4):363-369. Epub 2018 Dec 21.

Faculty of Science, Department of Physics, University of Selçuk, Selçuklu, Konya, 42031, Turkey.

Background: Femtosecond (fs) Laser Ionisation Mass Spectrometry (fs-LIMS) on colon tissues are described and investigated using ionization/fragmentation processes in details to present a new application in this study. Linear Time of Flight (L-TOF) mass analyzer was utilized to investigate paraffin-embedded human tissue in this study. The effect of fs laser intensity on the spectral characteristics was investigated and interpreted due to mass spectra obtained using 800 nm wavelength with 90 fs pulses at 1 kHz repetition rate. Read More

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http://dx.doi.org/10.1002/lsm.23033DOI Listing
April 2019
2 Reads

Impact of photodynamic therapy versus ultrasonic scaler on gingival health during treatment with orthodontic fixed appliances.

Lasers Surg Med 2019 Mar 21;51(3):256-267. Epub 2018 Dec 21.

Complutense University of Madrid, School of Dentistry, Stomatology IV Department, Plaza Ramón y Cajal sn, 28040, Madrid, Spain.

Objectives: Poor oral hygiene during treatment with fixed appliances results in plaque accumulation. The presence of bacteria in the gingival crevice triggers an inflammatory reaction in the gingival tissues. The aim of this study was to compare the impact of two preventive treatments, photodynamic therapy (PDT), and ultrasonic scaler (US), on gingival health in patients under fixed orthodontic treatment. Read More

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http://dx.doi.org/10.1002/lsm.23035DOI Listing
March 2019
1 Read

Science and peace.

Authors:
Kristen M Kelly

Lasers Surg Med 2019 Jan 18;51(1):5-7. Epub 2018 Dec 18.

Beckman Laser Institute, University of California, Irvine, California 92697.

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http://dx.doi.org/10.1002/lsm.23043DOI Listing
January 2019