72,818 results match your criteria Lasers in Medical Science [Journal]


Suprathreshold laser injuries in excised porcine skin for millisecond exposures at 1070 nm.

J Biomed Opt 2018 Dec;23(12):1-11

711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Optical Radiation Bio, United States.

Skin injury response to near-infrared (NIR) laser radiation between the minimum visible lesion threshold and ablation onset is not well understood. This study utilizes a 1070-nm diode-pumped Yb-fiber laser to explore the response of excised porcine skin to high-energy exposures in the suprathreshold injury region without inducing ablation. Concurrent high-speed videography is employed to determine a dichotomous response for three progressive damage categories: observable surface distortion, surface bubble formation due to contained intracutaneous water vaporization, and surface bubble rupture during exposure. Read More

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December 2018
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Induction of fat apoptosis by a non-thermal device: Mechanism of action of non-invasive high-intensity electromagnetic technology in a porcine model.

Lasers Surg Med 2018 Dec 14. Epub 2018 Dec 14.

Veterinary Research Institute, Brno, Czech Republic.

Objectives: While controlled thermal changes in subcutaneous tissue have been used to trigger apoptosis of fat cells and have been proven clinically efficacious, another mechanism of electromagnetic stress suggests that fat apoptosis could be achieved by a non-thermal manner as well. This animal model study investigates the use of a non-invasive high-intensity magnetic field device to induce apoptosis in fat cells.

Methods: Yorkshire pigs (N = 2) received one treatment (30 minutes) in the abdominal area using a High-Intensity Focused Electromagnetic (HIFEM) device. Read More

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December 2018
1 Read

A readily usable two-photon FLIM microendoscope.

J Biophotonics 2018 Dec 11:e201800276. Epub 2018 Dec 11.

Université de Limoges, XLIM, Limoges, France.

A two-photon fluorescence lifetime (2P-FLIM) microendoscope, capable of energetic metabolism imaging through the intracellular NADH autofluorescence, at sub-cellular resolution, is demonstrated. It exhibits readily usable characteristics such as convenient endoscope probe diameter (≈ 2 mm), fiber length (> 5 m) and data accumulation rate (16 frames per second (fps), leading to a FLIM refreshing rate of ≈ 0.1 to 1 fps depending on the sample) . Read More

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December 2018

figHigh Spatial Resolution MALDI-MS Imaging in the Study of Membranous Nephropathy.

Proteomics Clin Appl 2018 Dec 7:e1800016. Epub 2018 Dec 7.

University of Milano-Bicocca, Department of Medicine and Surgery, Clinical Proteomics and Metabolomics Unit, Vedano al Lambro, Italy.

MALDI-MSI technology has advanced rapidly during recent years with the development of instruments equipped with low-diameter lasers that are suitable for high spatial resolution imaging. This may provide significant advantages in certain fields of molecular pathology where more specific protein fingerprints of individual cell types are required, such as renal pathology. Here we performed MALDI-MSI analysis of a cohort of MN patients among which patients either responded favourably (R; n = 6), or unfavourably (NR; n = 4), to immunosuppressive treatment (Ponticelli Regimen), employing a 10μm laser spot diameter. Read More

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December 2018

High-efficiency watt-level continuous-wave 2.9  μm Ho,Pr:YLF laser.

Opt Lett 2018 Dec;43(24):6109-6112

The bottleneck in Ho:I5→I52.9  μm laser emission, where the upper-level lifetime (I5) is significantly shorter than that of the lower-level (I5) lifetime, is overcome by co-doping Ho and Pr ions. A novel kind of Ho,Pr:YLIF (Ho,Pr:YLF) crystal is fabricated by optimizing the doping concentration ratios. Read More

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December 2018

Microfiber-enabled dissipative soliton fiber laser at 2  μm.

Opt Lett 2018 Dec;43(24):6105-6108

Optical microfibers can show very strong normal dispersion (as high as 2700  ps/km) around 2 μm, a highly desired feature for dispersion management in ultrafast lasers. Here we report a dissipative soliton fiber laser at 2 μm enabled by an optical microfiber. The full width at half-maximum of the optical spectrum was about 50 nm, and its flatness could be attributed to the third-order dispersion compensation provided by the optical microfiber. Read More

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December 2018

231  W dual-end-pumped Ho:YAG MOPA system and its application to a mid-infrared ZGP OPO.

Opt Lett 2018 Dec;43(24):5989-5992

A high-efficiency and high-brightness Ho:YAG master-oscillator power-amplifier (MOPA) system dual-end pumped by Tm:YLF lasers was demonstrated. The maximum output power of 231 W at a wavelength of 2090.7 nm was achieved with pulse repetition frequency of 10 kHz and pulse width of 22. Read More

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December 2018

Silicon-nanoparticle-based broadband optical modulators for solid-state lasers.

Opt Lett 2018 Dec;43(24):5957-5960

Motivated by the tremendous success of carbon nanomaterials in acting as optical nonlinear modulators, in this Letter, the optical nonlinearity of their counterpart, silicon nanoparticles (SiNPs), is investigated. For the first time, to the best of our knowledge, the nonlinear optical property of SiNPs in 1 μm and 2 μm wavelength bands is observed. Its practical modulation performance is investigated by employing SiNPs as a saturable absorber (SA) in pulsed lasers, and the fabrication process, surface morphology, and linear and nonlinear optical response properties of the prepared SiNPs-SA are presented. Read More

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December 2018

In-cavity soliton self-frequency shift ultrafast fiber lasers.

Opt Lett 2018 Dec;43(24):5913-5916

Lasing wavelengths are generally limited at the gain bands of active materials. In this Letter, we propose and demonstrate a new concept of ultrafast fiber laser based on in-cavity soliton self-frequency shift (SSFS). Benefiting from SSFS, the wavelength of ultrafast fiber lasers can be beyond the gain band of active fibers. Read More

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December 2018

The impacts of laser zona thinning on hatching and implantation of vitrified-warmed mouse embryos.

Lasers Med Sci 2018 Dec 13. Epub 2018 Dec 13.

National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Embryo vitrification has advantages in assisted reproduction yet it also induces zona hardening. Laser zona thinning (LZT) is considered as a solution yet its efficacy and security have not been well studied. In this study, we used vitrified-warmed morulae from 2-month-old and 10-month-old ICR female mice as model to investigate the impacts that LZT treatment brings to the in vitro hatching process and implantation by analyzing hatching rate, implantation rate, and blastocyst quality. Read More

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December 2018
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Low-level laser therapy versus trunk stabilization exercises on sternotomy healing after coronary artery bypass grafting: a randomized clinical trial.

Lasers Med Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Physical Therapy for Internal Medicine, Faculty of Physical Therapy, Cairo University, Giza, Egypt.

The aim of this study was to investigate the effects of low-level laser therapy (LLLT) versus trunk stabilization exercises on sternotomy healing following coronary artery bypass grafting (CABG) surgery. Forty-five male patients who had acute sternal instability post-CABG surgery in the age range of 45-65 years were divided randomly into three equal groups (n = 15). The laser group received LLLT, while the exercise group received trunk stabilization exercises. Read More

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December 2018
2 Reads

Retinal burns from laser pointers: a risk in children with behavioural problems.

Eye (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Bolton Hospitals NHS Foundation Trust, Bolton, UK.

Objective: To explore self-inflicted retinal burns from laser pointers in children.

Methods: Literature review of laser pointer retinal injuries in childhood and online survey of UK Consultant Ophthalmologists. A cohort of local children with self-inflicted injury is described. Read More

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December 2018

Efficacy of laser surgery versus radiotherapy for treatment of glottic carcinoma: a systematic review and meta-analysis.

Lasers Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Nursing College of Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China.

Laser surgery and radiotherapy are the two most common ways to treat glottic carcinomas, which is more efficacious and remains controversial. PubMed, Embase, and Cochrane Library were searched to identify relevant studies of laser surgery versus radiotherapy in patients with glottic carcinomas through April 2017. Sensitivity analysis and subgroup analysis were performed to evaluate heterogeneity. Read More

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December 2018

Lasing Supraparticles Self-Assembled from Nanocrystals.

ACS Nano 2018 Dec 12. Epub 2018 Dec 12.

One of the most attractive foreseen commercial applications of semiconductor nanocrystals (NCs) is their use in lasers. Thanks to their high quantum yield, tunable optical properties, photostability and wet-chemical processability, NCs have arisen as promising gain material. Most of these applications, however, rely on incorporation of NCs in lasing cavities separately produced using sophisticated fabrication methods and often difficult to manipulate. Read More

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December 2018

One-Tube Multicolor Flow Cytometry Assay (OTMA) for Comprehensive Immunophenotyping of Peripheral Blood.

Methods Mol Biol 2019 ;1904:189-212

Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Recent improvements in the flow cytometry technology allow the determination of the general immune status through the development of multicolor immunofluorescence panels. The one-tube multicolor flow cytometry assay (OTMA) that is presented here identifies 20 different, clinically relevant immune cell subsets and three common activation markers. Thereby, a comprehensive immune status that covers all major immune cells is easily obtained. Read More

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January 2019

Optical coherence tomography imaging of melanoma skin cancer.

Lasers Med Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

No consensus guidelines exist on the use of optical coherence tomography (OCT) for diagnosis of cutaneous melanoma. The objectives of this review are to provide a descriptive review of the literature on characteristics of cutaneous melanomas seen on high-definition OCT (HD-OCT), speckle variance OCT (SV-OCT), and conventional OCT and to compare their diagnostic ability with that of histopathology. A review of PubMed and Google Scholar identified all available literature on OCT in melanoma skin cancer that included all in vivo and ex vivo studies on human or human tissues and excluded all studies on non-human subjects or animal studies. Read More

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December 2018
2 Reads

The effects of repeated applications of antimicrobial photodynamic therapy in the treatment of residual periodontal pockets: a systematic review.

Lasers Med Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Periodontology, Master of Science Program, Veiga de Almeida University, Rua Ibituruna 108, casa 3, sala 201, Tijuca, Rio de Janeiro, 20271-020, Brazil.

The aim of this study was to assess the effects of repeated applications of antimicrobial photodynamic therapy (aPDT) on the non-surgical periodontal treatment of residual pockets. This work was performed and reported according to the Cochrane and PRISMA recommendations, respectively, and registered at the PROSPERO registry (number CRD42017058403). An extensive search of the biomedical literature was conducted on four databases from January 1960 to August 2018, followed by hand searching. Read More

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December 2018

Cellular deoxyribonucleic-acid probes of two-photon-excited fluorescent quinolinium-substituted carbazole.

Analyst 2018 Dec 12. Epub 2018 Dec 12.

Key Lab of Functional Inorganic Material Chemistry, Heilongjiang University, no. 74 Xuefu Road, Nangang District, Harbin 150080, PR China. and Key Laboratory of Material Science and Technology for High Power Lasers, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, no. 390 Qinghe Road, Jiading District, Shanghai 201800, PR China.

We report three new types of two-photon-absorption compounds, which contain a carbazole center core linked to two quinolinium units. Their action two-photon absorption cross-sections are 287.13, 267. Read More

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December 2018

Laryngeal temperature simulations during carbon dioxide laser irradiation delivered by a scanning micromanipulator.

Lasers Med Sci 2018 Dec 7. Epub 2018 Dec 7.

Department. of Otolaryngology, Vanderbilt University Medical Center, 1215 21st Ave S., Nashville, TN, 37232, USA.

We use scatter-limited phototherapy techniques to calculate the time-dependent temperature profiles of incisions made with a commercial carbon dioxide laser being used to make a 1-mm incision under computer control using the Digital Acublade™ and with incisions made with the same laser under manual control. The goal is to understand the differences in the amount of lateral thermal damage that is likely from the computer-controlled incisions versus the manually controlled incisions. The temperature profiles are calculated from the absorption and scatter of light in a homogeneous material. Read More

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December 2018

THE DEVELOPMENT OF A NOVEL ARRAY DETECTOR FOR OVERCOMING THE DOSIMETRY CHALLENGES OF MEASURING IN VERY SHORT PULSED CHARGED PARTICLE BEAMS: THE ELIDOSE PROJECT.

Radiat Prot Dosimetry 2018 Dec 11. Epub 2018 Dec 11.

National Institute for Lasers, Plasma and Radiation Physics, Bucharest-409 Atomistilor St., Magurele, Ilfov County, Romania.

In-beam dose measurements are paramount for any application seeking to harness the effects of the radiation beam, so all the future applications of the laser accelerated beams (as generated in the ELI and CETAL projects) will need such measurements. With a very long history in measuring doses in charged particle beams, the medical and industrial applications setup a number of methods that could be also used for the dosimetry of the beams generated by laser pulses. Dose measurements rely heavily on what is seen as the gold standard in dose measurement: the ion chambers. Read More

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December 2018
1 Read

Laser-assisted Lipolysis Burn Safety: Proposed Detailed Parameters with Assessment of Their Efficacy and Safety.

Authors:
Yasser Helmy Ali

Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1934. Epub 2018 Oct 3.

Plastic and Burn Surgery Department, Al-Azhar University, Cairo, Egypt.

Background: Many recent studies have evaluated the clinical safety and efficacy of therapeutic lasers in laser lipolysis, but without detailed description of the safe and effective parameters.

Purpose: To propose a method for adjusting safe and effective parameters for laser lipolysis.

Methods: Detailed calculations of the safe and effective laser parameters for fat melting are proposed in the study. Read More

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October 2018

Wide-gamut lasing from a single organic chromophore.

Light Sci Appl 2018 5;7:101. Epub 2018 Dec 5.

1Department of Physics, University of Alberta, Edmonton, AB T6G2E1 Canada.

The development of wideband lasing media has deep implications for imaging, sensing, and display technologies. We show that a single chromophore can be engineered to feature wide-gamut fluorescence and lasing throughout the entire visible spectrum and beyond. This exceptional color tuning demonstrates a chemically controlled paradigm for light emission applications with precise color management. Read More

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December 2018

CRC4: Uses of Lasers in Prosthodontics.

J Indian Prosthodont Soc 2018 Oct;18(Suppl 1):S36

Buddha Institute of Dental Sciences and Hospital Gandhi Nagar, West of TV Tower, Kankarbagh, Patna, Bihar, India.

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October 2018

Optical Study of p-Doping in GaAs Nanowires for Low-Threshold and High-Yield Lasing.

Nano Lett 2018 Dec 11. Epub 2018 Dec 11.

School of Physics and Astronomy and the Institute for Compound Semiconductors , Cardiff University , Cardiff , CF10 3AT , United Kingdom.

Semiconductor nanowires suffer from significant non-radiative surface recombination; however, heavy p-type doping has proven to be a viable option to increase the radiative recombination rate and, hence, quantum efficiency of emission, allowing the demonstration of room-temperature lasing. Using a large-scale optical technique, we have studied Zn-doped GaAs nanowires to understand and quantify the effect of doping on growth and lasing properties. We measure the non-radiative recombination rate ( k) to be (0. Read More

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December 2018

Effects of near infrared focused laser on the fluorescence of labelled cell membrane.

Sci Rep 2018 Dec 5;8(1):17674. Epub 2018 Dec 5.

ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, 08860, Castelldefels, Barcelona, Spain.

Near infrared (NIR) laser light can have important reactions on live cells. For example, in a macroscopic scale, it is used therapeutically to reduce inflammation and in a single-cell scale, NIR lasers have been experimentally used to guide neuronal growth. However, little is known about how NIR lasers produce such behaviours on cells. Read More

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December 2018
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MAPLE Assembled Acetylcholinesterase⁻Polyethylenimine Hybrid and Multilayered Interfaces for Toxic Gases Detection.

Sensors (Basel) 2018 Dec 4;18(12). Epub 2018 Dec 4.

National Institute for Lasers, Plasma and Radiation Physics, Magurele RO, Bucharest 077125, Romania.

Developing a controlled method for obtaining hybrid enzymatic-based interfaces for sensing application require the use of a multiuse, reusable sensor. By controlling the interface characteristics in terms of the surface chemistry, thickness, and roughness, a tailored response toward various toxic compounds can be obtained, regarding both materials used as active surfaces and fabrication methods. Herein, we report a preliminary study on using a laser-based method (i. Read More

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December 2018
2 Reads

Outcomes of long-pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma: A retrospective review.

Lasers Surg Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Dermatology, University of California, San Diego School of Medicine, 9500 Gillman Drive, La Jolla, California, 92093.

Background And Objective: Recent prospective trials have supported treatment of nonfacial BCC with long-pulsed 1064 nm Nd:YAG laser based on short-term histologic clearance rates. Studies have yet to identify the long-term clinical clearance rates of this specific laser therapy for BCC.

Study Design/material And Methods: This is a retrospective review of BCC treated with long-pulsed 1064 nm Nd:YAG laser, which have been clinically monitored for at least 6 months, to assess for recurrence and cosmetic outcomes of the treated area. Read More

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December 2018

Nd:YAG laser and calcium sodium phosphosilicate prophylaxis paste in the treatment of dentin hypersensitivity: a double-blind randomized clinical study.

Clin Oral Investig 2018 Nov 30. Epub 2018 Nov 30.

Special Laboratory of Lasers in Dentistry (LELO), Department of Restorative Dentistry, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.

Aim: This double-blind, placebo-controlled, randomized clinical trial evaluated the effectiveness of Nd:YAG laser and a calcium sodium phosphosilicate-containing paste (NovaMin®) in the treatment of cervical dentin hypersensitivity (CDH).

Materials And Methods: Seventy patients were randomly allocated into the following experimental groups: control-placebo, calcium sodium phosphosilicate paste (NovaMin®), and Nd:YAG laser (1 W, 10 Hz, 85 J/cm). Pain was evaluated by means of a visual analog pain scale (VAS) after evaporative stimulation with a jet of air and tactile stimulation with an exploratory probe, before treatment (baseline) and after 5 min, 1week, and 4 weeks. Read More

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November 2018
1 Read

Diffracted X-ray Blinking Tracks Single Protein Motions.

Sci Rep 2018 Nov 30;8(1):17090. Epub 2018 Nov 30.

Research & Utilization Div., Japan Synchrotron Radiation Research Institute, 1-1-1, Kouto, Sayo-cho, Sayo-gun, Hyogo, 567-5198, Japan.

Single molecule dynamics studies have begun to use quantum probes. Single particle analysis using cryo-transmission electron microscopy has dramatically improved the resolution when studying protein structures and is shifting towards molecular motion observations. X-ray free-electron lasers are also being explored as routes for determining single molecule structures of biological entities. Read More

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November 2018
1 Read

Author Correction: Ultrafast switch-on dynamics of frequency-tuneable semiconductor lasers.

Nat Commun 2018 11 30;9(1):5181. Epub 2018 Nov 30.

School of Electronic and Electrical Engineering, University of Leeds, Leeds, LS2 9JT, UK.

The original version of this Article contained an error in the Acknowledgements, which incorrectly omitted the following: 'We also acknowledge support from the Australian Research Council's Discovery Projects Funding Scheme (Grant DP 160 103910).' This has been corrected in both the PDF and HTML versions of the Article. Read More

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November 2018

Comparison of the micro-tensile bond strengths of four different universal adhesives to caries-affected dentin after ER:YAG laser irradiation.

Dent Mater J 2018 Dec 1. Epub 2018 Dec 1.

Department of Restorative Dentistry, Faculty of Dentistry, Istanbul Aydın University.

The micro-tensile bond strengths (micro-TBSs) of four universal adhesive systems, applied in two different bonding techniques, to carries-affected dentin after Er:YAG laser irradiation were investigated. Twenty-four extracted human molars were divided into four groups, according to the adhesive systems used. Each group was subdivided into two subgroups, depending on the bonding method used: the etch-and-rinse procedure or self-etch procedure. Read More

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December 2018
1 Read

Non-linear soft x-ray methods on solids with MUSIX-the multi-dimensional spectroscopy and inelastic x-ray scattering endstation.

J Phys Condens Matter 2019 Jan;31(1):014003

Deutsches Elektronen Synchrotron DESY, Notkestr. 85, 22607 Hamburg, Germany. Physics Department, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany.

With the intense and coherent x-ray pulses available from free-electron lasers, the possibility to transfer non-linear spectroscopic methods from the laser lab to the x-ray world arises. Advantages especially regarding selectivity and thus information content as well as an improvement of signal levels are expected. The use of coherences is especially fruitful and the example of coherent x-ray/optical sum-frequency generation is discussed. Read More

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January 2019

Time-resolved double-resonance spectroscopy: Lifetime measurement of the electronic state of molecular sodium.

J Chem Phys 2018 Nov;149(20):204302

Department of Physics, Miami University, Oxford, Ohio 45056, USA.

We report on the lifetime measurement of the state of Na molecules, produced in a heat-pipe oven, using a time-resolved spectroscopic technique. The level was populated by two-step two-color double resonance excitation via the intermediate state. The excitation scheme was done using two synchronized pulsed dye lasers pumped by a Nd:YAG laser operating at the second harmonics. Read More

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November 2018
1 Read

Tunable colloidal quantum dot distributed feedback lasers integrated on a continuously chirped surface grating.

Nanoscale 2018 Dec;10(48):22745-22749

Department of Physics and Astronomy, Seoul National University, Seoul 08826, Republic of Korea.

We report a colloidal quantum dot (CQD) distributed feedback (DFB) laser structure containing a chirped grating. The device exhibits single-mode DFB lasing, of which the wavelength is spatially dispersed in a single chip. A period-chirped surface grating is fabricated using a modified Lloyd-type laser interference lithography setup, where a flat Lloyd's mirror is replaced with a concave one. Read More

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December 2018

Intravitreal ranibizumab versus laser photocoagulation for retinopathy of prematurity: efficacy, anatomical outcomes and safety.

Br J Ophthalmol 2018 Dec 4. Epub 2018 Dec 4.

Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

Background/aims: To compare the efficacy, anatomical outcomes and complications of intravitreal ranibizumab with those of laser photocoagulation for retinopathy of prematurity (ROP).

Methods: This is a retrospective case series of 314 eyes from 165 infants diagnosed with type I ROP and treated with either laser photocoagulation (161 eyes) or intravitreal ranibizumab (0.25 mg/0. Read More

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December 2018
1 Read

Decontamination of Dental Implant Surfaces by the Er:YAG Laser Beam: A Comparative in Vitro Study of Various Protocols.

Dent J (Basel) 2018 Dec 1;6(4). Epub 2018 Dec 1.

Department of Dental Science, Faculty of Medicine, University of Liege, 4020 Liege, Belgium.

Oral rehabilitation with dental implants has revolutionized the field of dentistry and has been proven to be an effective procedure. However, the incidence of peri-implantitis has become an emerging concern. The efficacy of the decontamination of the implant surface, by means of lasers, is still controversial. Read More

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December 2018
1 Read

Design and Synthesis of Conjugated Starburst Molecules for Optoelectronic Applications.

Chem Rec 2018 Dec 4. Epub 2018 Dec 4.

Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China.

In recent years, conjugated starburst molecules, which possess a core unit with radial arms linked to the central axle, have become the research topic owing to their well-defined chemical structures, good solution processability, excellent reproducibility, and superior optoelectronic properties. The increasing interest in starburst systems is evidenced by progressively more frequent investigation on the use of these materials in optoelectronics. The ability to modify chemical structures through control over the core and arms on a molecular level can directly affect the electronic and electroluminescent characteristics of the resulting materials. Read More

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December 2018
6 Reads

Platelet-rich plasma versus combined fractional carbon dioxide laser with platelet-rich plasma in the treatment of vitiligo: a comparative study.

Clin Cosmet Investig Dermatol 2018 8;11:551-559. Epub 2018 Nov 8.

Dermatology Unit, Department of Medical Applications of Lasers (MAL), National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt,

Purpose: The aim of this study was to assess the efficacy of platelet-rich plasma (PRP) vs combined fractional CO (Fr: CO) laser with PRP in the treatment of stable nonsegmental vitiligo (NSV) lesions.

Patients And Methods: This prospective, randomized, intrapatient, comparative controlled study was conducted between June 2014 and June 2016 at National Institute of Laser Enhanced Sciences (NILES), Cairo University, Cairo, Egypt. Thirty NSV patients were treated with PRP, Fr: CO laser, and combined Fr: CO laser with PRP. Read More

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November 2018
4 Reads

Anomalous material-dependent transport of focused, laser-driven proton beams.

Sci Rep 2018 Dec 3;8(1):17538. Epub 2018 Dec 3.

Center for Energy Research, University of California, San Diego, La Jolla CA, 92093-0417, USA.

Intense lasers can accelerate protons in sufficient numbers and energy that the resulting beam can heat materials to exotic warm (10 s of eV temperature) states. Here we show with experimental data that a laser-driven proton beam focused onto a target heated it in a localized spot with size strongly dependent upon material and as small as 35 μm radius. Simulations indicate that cold stopping power values cannot model the intense proton beam transport in solid targets well enough to match the large differences observed. Read More

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December 2018

Excitation-multiplexed multicolor superresolution imaging with fm-STORM and fm-DNA-PAINT.

Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.

ICFO - Institut de Ciencies Fotoniques, Barcelona Institute of Science and Technology, 08860 Castelldefels, Barcelona, Spain;

Recent advancements in single-molecule-based superresolution microscopy have made it possible to visualize biological structures with unprecedented spatial resolution. Determining the spatial coorganization of these structures within cells under physiological and pathological conditions is an important biological goal. This goal has been stymied by the current limitations of carrying out superresolution microscopy in multiple colors. Read More

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December 2018
1 Read

1-(2-Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate to non-sulfonamide carbonic anhydrase II inhibitors, synthesis via Sonogashira coupling, binding analysis, Lipinsk's rule validation.

Bioorg Chem 2018 Nov 24;84:170-176. Epub 2018 Nov 24.

Department of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongjudehak-Ro, Gongju, Chungnam 314-701, Republic of Korea.

A novel series of silyl-yne containing chalcone derivatives 5a-5j was synthesized by exploiting Sonogashira coupling reaction and Claisen-Schimdt condensation reaction. The synthesized derivative were characterized by spectroscopic and elemental analysis. The selective inhibition of carbonic anhydrases is considered critical in the field of medicinal chemistry because carbonic anhydrases exits in several isoforms. Read More

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November 2018
2.152 Impact Factor

A Comparative Split-Face Trial of Plant-Based Hypoallergenic Ointment vs Petroleum-Based Ointment Following Fractionated Carbon Dioxide Laser Resurfacing of the Face

J Drugs Dermatol 2018 Nov;17(11):1178 - 1182

Purpose: Fractionated carbon dioxide (CO2) laser resurfacing uses fractional photothermolysis with an ablative 10,600-nm wavelength for treatment of rhytides and photodamage. Although associated with reduced side effect profile from traditional ablative lasers, fractionated lasers can lead to significant erythema, edema, crusting, and exudation for 14 days. Post-care includes regular distilled water soaks and healing ointment. Read More

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November 2018
5 Reads

Integrated Cooling-Vacuum-Assisted Non-Fractional 1540-nm Erbium:Glass Laser: A New Modality for the Simultaneous Effective Treatment of Acne Lesions and Scars

J Drugs Dermatol 2018 11;17(11):1173 - 1176

Introduction: Acne vulgaris is a common skin disorder with a significant impact on patients' quality of life. There is currently no treatment designated to treat acne lesions and scars concurrently. However, mid-infrared lasers may promote neocollagenesis within atrophic scars, while exerting a beneficial effect on acne lesions. Read More

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November 2018
2 Reads

Narrowing spectral linewidth in passively mode-locked solid-state lasers.

Opt Lett 2018 Dec;43(23):5753-5756

A novel scheme to realize a mode-locked laser with a narrow spectral linewidth is demonstrated by exploiting a reflected Fabry-Perot (FP) cavity to introduce an intense FP effect. Stable continuous-wave mode-locked operation is achieved with the repetition rate of 48 MHz and the maximum average output power of 2.6 W under an incident pump power of 11. Read More

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December 2018
1 Read

Efficiency increase of distributed feedback Raman fiber lasers by dynamic control of the phase shift.

Opt Lett 2018 Dec;43(23):5705-5708

π-phase-shifted distributed feedback, ultralong fiber Bragg gratings (FBGs) with Raman gain have been shown to be excellent ultranarrow single-frequency lasers that can be operated at any wavelength. However, these lasers have shown unusually low slope efficiency (1%-10%), while theoretical simulations predict a much higher (30%-60%) number. We believe this poor performance is due to a thermally induced phase shift inside the FBG due to absorption of the high intensity of the signal oscillating in the cavity. Read More

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December 2018
3 Reads

High-efficiency 3  μm Er:YGG crystal lasers.

Opt Lett 2018 Dec;43(23):5873-5876

By balancing energy transfer and thermal effects, we demonstrate efficient erbium-doped yttrium gallium garnet (Er:YGG) crystal lasers at a wavelength of 2.82-2.92 μm for the first time, to the best of our knowledge. Read More

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December 2018
1 Read

Ultrafast thulium fiber laser system emitting more than 1  kW of average power.

Opt Lett 2018 Dec;43(23):5853-5856

In this Letter, we report on the generation of 1060 W average power from an ultrafast thulium-doped fiber chirped pulse amplification system. After compression, the pulse energy of 13.2 μJ with a pulse duration of 265 fs at an 80 MHz pulse repetition rate results in a peak power of 50 MW spectrally centered at 1960 nm. Read More

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December 2018

Laser-induced tissue remodeling within the tympanic membrane.

J Biomed Opt 2018 Nov;23(12):1-8

University of Saarland, Department of Otorhinolaryngology, Homburg, Germany.

The tympanic membrane (TM) separates the outer ear from the tympanic cavity. Repeated pathologies can permanently decrease its tension, inducing conductive hearing loss and adhesive processes up to cholesteatoma. The current main therapy is its surgical reconstruction. Read More

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November 2018
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Essential Role of mTOR Signaling in Human Retinal Pigment Epithelial Cell Regeneration After Laser Photocoagulation.

Lasers Med Sci 2018 Nov 29. Epub 2018 Nov 29.

Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang Graduate School, Bucheon Hospital, Bucheon, South Korea.

This study assessed the role of mechanistic target of rapamycin (mTOR) pathway in the human adult retinal pigment epithelial (ARPE) cell response after laser photocoagulation (LP). The effect of mTOR inhibition on ARPE-19 cell was investigated by rapamycin treatment after LP. Cell viability and proliferation were explored using MTT and EdU assays, respectively. Read More

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November 2018
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The retinal pigment epithelial response after retinal laser photocoagulation in diabetic mice.

Lasers Med Sci 2018 Nov 29. Epub 2018 Nov 29.

Department of Ophthalmology, Soonchunhyang University Hospital Bucheon, Soonchunhyang University College of Medicine, #170 Jomaru-ro, Bucheon-si, Gyeonggi-do, 14584, South Korea.

To investigate the characteristics of regenerated retinal pigment epithelial (RPE) cells after retinal laser photocoagulation in diabetic mice. C57BL/6J mice were used to induce diabetes using intraperitoneal injection of streptozotocin. The proliferation of RPE cells after laser photocoagulation was determined using the 5-ethynyl-2'-deoxyuridine (EdU) assay in both diabetic and wild-type mice. Read More

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November 2018
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