Search Our Scientific Publications & Authors

Clin Dermatol 2022 May-Jun;40(3):274-282. Epub 2021 Feb 2.

Department of Dermatology, Alpert Medical School, Brown University, Providence, Rhode Island, USA; GK Dermatology, PC, South Weymouth, Massachusetts, USA; Department of Dermatology, Medical School of Jundiaí, São Paulo, Brazil. Electronic address:

Skin resurfacing for cutaneous rejuvenation has evolved with the development of a plethora of nonsurgical and minimally invasive modalities. We have highlighted the advances in laser therapy, chemical peels, radiofrequency, microneedling, and platelet-rich plasma therapy. We have also included studies providing head-to-head comparisons between procedures and discussed relevant debates in the field. Read More

Dermatol Surg 2022 04;48(4):441-448

Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Background: Lasers and energy-based devices (EBD) are popular treatments for skin rejuvenation and resurfacing. Achieving desired outcomes and avoiding complications require understanding the effects of these devices at a histologic level. Currently, no comprehensive review summarizing the histologic effects of laser and energy-based treatments exists. Read More

J Cosmet Laser Ther 2021 Aug 2;23(5-6):97-104. Epub 2022 Feb 2.

Physics and Laser Technology, The Higher Institute for Laser Research and Applications, Laboratroy of Medical Laser, Syria.

Fractional laser (FL) resurfacing has proved its effectiveness in acne scars treatments. To evaluate the efficacy of Fractional laser systems for treatment of acne scars as a monotherapy, and as adjunctive therapy with other treatment types. A systematic literature review was performed by searching the electronic databases PubMed, Google Scholar, and Embase. Read More

J Cosmet Dermatol 2022 Mar 22;21(3):991-997. Epub 2022 Jan 22.

Skinfiniti Aesthetic Skin and Laser Clinic, Mumbai, India.

Aim And Objectives: Evaluation of the cumulative effect of Radiofrequency Microneedling and fractional Erbium: Glass 1565 laser in moderate to severe acne scars in skin of color.

Material And Methods: This retrospective study was conducted on 20 patients of skin types III -V having moderate to severe atrophic acne scars. The study was carried out over 1 year from March 2019 to March 2020. Read More

Facial Plast Surg 2022 Apr 7;38(2):163-165. Epub 2022 Jan 7.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Following our survey, we can appreciate that a variety of laser platforms exist to rejuvenate the skin by resurfacing the outer layer of the skin as well as heating the lower layers of the dermis. Based on reliable clinical effectiveness and a limited side effect profile, we can confirm that nonablative fractionated technologies greatly improve the appearance of lentigines, rhytids; eliminate sun damage, attenuate scarring due to acne and other causes; and treat hyperpigmentation. The Fraxel (Solta Medical) laser system delivers pulses across a wide range of density and energy levels. Read More

Dermatol Surg 2022 02;48(2):201-206

Department of Dermatology, University of California, Irvine, California.

Background: Despite history of multiple treatment modalities, repigmentation of hypopigmented scars remains a difficult clinical problem.

Objective: The purpose of this review is to evaluate the literature on laser and combination laser plus adjunct topical therapy for hypopigmented burn and traumatic scars.

Materials And Methods: A search on PubMed and on Oxford Academic was conducted with additional relevant literature obtained from reference lists. Read More

Appl Opt 2021 Jul;60(21):6189-6198

In this in vitro experiment, the effect of 1.064 µm pulsed laser on both enamel- and dentin-dental tissues has been investigated. A total of fifty-five dental hard tissue samples were exposed to Nd:YAG laser that possesses a pulse width of 9 ns and 850 mJ of total energy. Read More

J Cosmet Dermatol 2021 Nov 1;20(11):3482-3491. Epub 2021 Oct 1.

Department of Clinical Anatomy, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

Background: Current options for the reduction of acne scarring (eg, ablative laser resurfacing) are associated with considerable side effects and limitations in terms of patient population. Percutaneous collagen induction via microneedling poses an alternative treatment method due to its low rates of reported adverse events and side effects.

Objective: To assess the safety and effectiveness of microneedling treatments in reducing acne scars. Read More

J Dtsch Dermatol Ges 2021 11 23;19(11):1559-1568. Epub 2021 Sep 23.

Translational Research Institute, Hamad Medical Corporation, Doha, Qatar.

Recent advances in laser technology allowed the development of systems that improve texture, appearance and pliability of skin in acne scars (AS). Currently, comprehensive comparative studies on the efficacy of the most commonly used fractional systems in AS are lacking. Thus, the aim of this work was to appraise and compare the clinical response to erbium versus CO lasers in AS in the form of a meta-analysis. Read More

Lasers Surg Med 2022 01 20;54(1):54-61. Epub 2021 Jul 20.

Lumenis, Yokneam, Israel.

Background: Fractional radiofrequency (RF) microneedling technologies have shown effectiveness in treating skin laxity and wrinkles. We report the first experience using a novel device with 1-mm long ultrathin electrodes that utilizes a smooth RF-assisted ablation mode.

Objective: To evaluate the safety and effectiveness of treatment with a fractional RF device using 1. Read More

Int J Cosmet Sci 2021 Oct 25;43(5):518-529. Epub 2021 Aug 25.

The Procter & Gamble Company, Cincinnati, Ohio, USA.

Objective: To explore synergistic effects related to skin regeneration, peptides with distinct biological mechanisms of action were evaluated in combination with different skin cell lines in the presence or absence of niacinamide (Nam). Furthermore, the synergistic responses of peptide combinations on global gene expression were compared with the changes that occur with fractional laser resurfacing treatment, a gold standard approach for skin rejuvenation, to further define optimal peptide combinations.

Methods: Microarray profiling was used to characterize the biological responses of peptide combinations (+/- Nam) relative to the individual components in epidermal keratinocyte and dermal fibroblast cell lines. Read More

Georgian Med News 2021 May(314):134-139

Central Research Institute of Radiation Diagnostics, Russian Federation.

High-resolution ultrasound (US) was used to examine 25 patients before the procedure and at the 2nd, 7th, 21st days and in 1.5 months after combined exposure to the skin of the face and neck with the Er:YAG laser in cold ablation mode and with the neodymium (Nd:YAG) laser in long pulse mode. The maximum dermis thickness was noted in the middle third (the standard measurement point along the mid-pupillary line in the projection of the infraorbital foramen) and composed 1,75±0,29 mm, the minimum on the neck and in infraorbital area - 1,2 (1,15; 1,3) mm and 1,15±0,15 mm, respectively. Read More

Photodermatol Photoimmunol Photomed 2022 Jan 6;38(1):29-37. Epub 2021 Jul 6.

Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.

Background: Atrophic post-acne scarring is considered to be a therapeutic challenge.

Objectives: The aim was to compare the safety and efficacy of (A) FCL combined with intradermal injection of plasma gel, (B) FCL combined with topical application of plasma gel, and (C) FCL monotherapy in the treatment of atrophic post-acne scars.

Methods: Thirty patients with facial atrophic post-acne scars were enrolled in this study and randomly assigned into one of three groups. Read More

Sci Rep 2021 06 11;11(1):12385. Epub 2021 Jun 11.

Pharmaceutical Research Group, School of Allied Health, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Bishops Hall Lane, Chelmsford, CM1 1SQ, UK.

Measuring outcomes from treatments to the skin is either reliant upon patient's subjective feedback or scale-based peer assessments. Three-Dimensional stereophotogrammetry intend to accurately quantify skin microtopography before and after treatments. The objective of this study is comparing the accuracy of stereophotogrammetry with a scale-based peer evaluation in assessing topographical changes to skin surface following laser treatment. Read More

Skin Pharmacol Physiol 2021 26;34(5):262-270. Epub 2021 May 26.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Ablative fractional carbon dioxide laser (AFCO2) resurfacing causes transient skin barrier disruption characterized by decreased skin hydration and increased transepidermal water loss (TEWL). Snail Soothing and Repairing (SSR) cream, containing several glycoproteins with potential antimicrobial and antioxidant effects, may benefit skin hydration promotion after the laser treatment.

Objective: To evaluate the efficacy and safety of SSR cream in skin hydration promotion after AFCO2 resurfacing. Read More

Facial Plast Surg 2021 Aug 14;37(4):424-431. Epub 2021 May 14.

Department of Otolaryngology, Head and Neck Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Soft tissue trauma to the face is challenging to manage due to functional and aesthetic concerns. Management requires careful regional considerations to maintain function such as visual fields and oral competence in periorbital and perioral injuries, respectively. Basic wound management principles apply to facial soft tissue injuries including copious irrigation and tension-free closure. Read More

J Cosmet Laser Ther 2020 Nov 4;22(6-8):241-243. Epub 2021 May 4.

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Minimally invasive fractional rejuvenation was developed to overcome the drawbacks of the traditional ablative laser. The Fotona 4D laser is one of these lasers used for face lifting. This laser uses two wavelengths such as Nd-YAG 1064 and Er-YAG 2940 nm in four different modes of non-ablative and ablative fractional laser to induce bulk heating in different tissue layers of facial skin. Read More

Life (Basel) 2021 Apr 17;11(4). Epub 2021 Apr 17.

Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei 114, Taiwan.

Background: During ablative fractional resurfacing (AFR) laser therapy, thermal damage to the skin is inevitable, resulting in inflammatory responses and small wounds. Corticosteroids are known for their anti-inflammatory effect. However, inappropriate application of corticosteroids carries the risk of delayed wound healing. Read More

Aesthetic Plast Surg 2021 10 21;45(5):2363-2374. Epub 2021 Apr 21.

Pharmaceutical Research Group, Faculty of Health, School of Allied Health, Education, Medicine and Social Care, Anglia Ruskin University, Bishops Hall Lane, Chelmsford, CM1 1SQ, UK.

Background: Scarring can jeopardize the final result of plastic surgeries. Deep dermal injuries activate dermal fibroblasts that produce excessive amount of collagen and inflammatory cytokines and growth factors, which contributes to increased fibrous tissue and scarring tissue formation.

Objectives: The aim of this early study, double-blind, prospective, randomised clinical trial was to investigate the use of laser-assisted drug delivery (LADD) for scar improvement to support the establishment of LADD as standard therapy modality and to indicate suitable drugs for dermal administration. Read More

Dermatol Surg 2021 04;47(4):496-499

Fotona d.o.o., Ljubljana, Slovenia.

Background: Successful treatment of acne scars in ethnic skin requires procedures that are safe and effective with a low incidence of hyper or hypopigmentation postoperatively.

Objective: In this study, the safety and efficacy of a combined treatment protocol including tumescent anesthesia, subcision, trichloracetic acid peel, and fractional erbium laser resurfacing was evaluated.

Methods: This is a retrospective study of 56 patients (22 women and 34 men) with predominantly rolling acne scars and Fitzpatrick skin Types IV-VI who were treated using a combination of tumescent anesthesia, extensive subcision, fractional ablative erbium laser, and a blending 20% trichloracetic acid (TCA) peel. Read More

Lasers Surg Med 2021 11 1;53(9):1266-1278. Epub 2021 Apr 1.

Faculty of Mechanical Engineering, University of Ljubljana, Askerceva 6 SI-1000, Ljubljana, Slovenia.

Background And Objectives: Recently, several minimally invasive gynecological, ENT and esthetic procedures have been introduced that are based on delivering "smooth" sequences of Er:YAG laser pulses to cutaneous or mucosal tissue at moderate cumulative fluences that are not only below the ablation threshold but typically also do not require local anesthesia.  To explain the observed clinical results using "smooth-resurfacing," it has been suggested that in addition to the direct heat injury to deeper-lying connective tissues, there is an additional mechanism based on indirect triggering of tissue regeneration through short-exposure, intense heat shocking of epithelia. The goal of this study is to improve understanding of the complex dynamics of the exposure of tissues to a series of short Er:YAG laser pulses, during which the thermal exposure times transition from extremely short to long durations. Read More

Urol Oncol 2022 05 17;40(5):179-183. Epub 2021 Feb 17.

Penile Cancer Centre, St George's Healthcare NHS Trust, London, UK.

With the passage of time, there has been a major paradigm shift in the surgical management of penile cancer from radical to organ preserving penile surgical techniques, with closer surgical margins which offer good oncological, cosmetic and functional outcomes with improved physical and psychosexual well-being. This article aims to provide an update of the current organ preserving surgical strategies for penile cancer. Read More

J Drugs Dermatol 2021 01;20(1):23-29

Background: Absorbable suspension sutures are an effective nonsurgical modality for correction of ptosis and tissue repositioning in the face and neck. The PLLA/PLGA suture is entirely absorbable and has a dual effect in that it both lifts tissues and induces collagenesis, thereby restoring contour. In clinical practice, nonsurgical modalities are rarely used in isolation, and combination treatments with fillers, neuromodulators, lipolysis, and energy-based devices are common. Read More

Semin Plast Surg 2020 Nov 24;34(4):305-313. Epub 2020 Dec 24.

Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas.

The process of scar formation is a sequela of the healing following soft tissue injury extending to, or through, the reticular dermis. Scars, within the head and neck in particular, may be physically disfiguring with resultant psychosocial implications. Mitigation of excessive scar formation during the healing process following surgery, or in the setting of trauma, begins with meticulous soft tissue handling and reconstructive technique. Read More

Lasers Surg Med 2021 09 16;53(7):899-905. Epub 2020 Dec 16.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

Background And Objective: Fractional 1064-nm picosecond-domain laser has recently been utilized for the treatment of atrophic acne scars and showed promising results. However, data on the safety and efficacy of this procedure in dark-skinned patients are limited. This prospective, self-controlled study was conducted to objectively evaluate the safety and efficacy of a 1064-nm picosecond laser coupled with a microlens array (MLA) for the treatment of atrophic acne scars on Asian skin. Read More

J Drugs Dermatol 2020 Nov;19(11):1050-1055

Laser resurfacing has progressed since the 1980s to treat a variety of medical and aesthetic indications with ever-evolving safety parameters. While laser technology has evolved to provide a more favorable safety profile and decrease wound healing time, advances in post-procedure healing agents have also helped to mitigate adverse effects, such as persistent erythema, dyspigmentation, acneiform eruptions, dermatitis, infections, and scarring. We reviewed the evidence of growth factors, stem cells, silicone and silicone polymers, botanical based treatments, fatty acids, probiotics, and closed dressings on post-ablative laser skin resurfacing. Read More

J Drugs Dermatol 2020 Nov;19(11):1112-1115

Ablative fractional resurfacing (AFR) can be utilized to improve scar appearance, texture, pain and associated contractures. Non-healing ulcers can also develop in areas of scarring and, in some cases, AFR can be utilized to heal these chronic wounds. We present a case of scarring with non-healing ulceration refractory to wound care, debridement and hydrotherapy successfully healed in four sessions with AFR using a 2940 nm Er:YAG laser. Read More

Lasers Surg Med 2021 01 8;53(1):115-118. Epub 2020 Nov 8.

SkinCare Physicians, Chestnut Hill, Massachusetts.

Introduction: The COVID-19 pandemic requires us all to re-evaluate aesthetic practices to ensure optimal patient safety during elective procedures. Specifically, energy-based devices and lasers require special consideration, as they may emit plume which has been shown to contain tissue debris and aerosolized biological materials. Prior studies have shown transmission of viruses and bacteria via plume (i. Read More

Burns 2021 06 17;47(4):785-795. Epub 2020 Oct 17.

Burns Unit, Concord Repatriation General Hospital, Sydney, Australia; ANZAC Research Institute, Concord Repatriation General Hospital, Sydney, Australia; Concord Clinical School, University of Sydney, Sydney, Australia.

Background: Burn scars are a major clinical challenge. The aim of this study was to determine the effectiveness and safety of one treatment with the ablative fractional CO laser (AFL-CO) compared to standard burn scar treatment.

Method: From December 2014 to October 2018 patients were prospectively recruited and treatment effects analyzed by assessing various outcome parameters from the date of first consultation and after treatment. Read More

Dermatol Ther 2021 01 2;34(1):e14432. Epub 2020 Nov 2.

Skin & Laser Surgery Center of New England, Nashua, New Hampshire, USA.

It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA-compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms "ablative laser" and "skin resurfacing" from March 2002 until July 2020. Studies included meta-analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. Read More