92,857 results match your criteria Laryngeal and Tracheal Stents


Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision-tree analysis.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Otolaryngology Department, Hospital Clínic, Barcelona, Spain.

Background: Indications of transoral laser microsurgery (TLM) are conditioned by the risk of local relapse.

Objective: To evaluate prognostic factors of local relapse and local control with TLM (LC-TLM).

Methods: Local relapse and LC-TLM were evaluated in 1119 patients. Read More

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December 2018

Early experience of transoral thyroidectomy: Comparison of robotic and endoscopic procedures.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The aim of this study was to evaluate the feasibility, safety, and early surgical outcomes of transoral thyroidectomy and to compare robotic and endoscopic procedures.

Methods: A total of 37 patients underwent robotic (23 cases) or endoscopic (14 cases) transoral thyroidectomy. We compared the outcomes of the two procedures. Read More

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December 2018
3 Reads

Unexpected discrepancies in hospital administrative databases can impact the accuracy of monitoring thyroid surgery outcomes in France.

PLoS One 2018 6;13(12):e0208416. Epub 2018 Dec 6.

Department of General and Endocrine Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.

Objective: To determine the validity of hospital administrative databases compared to prospective collection of medical data assessing thyroid surgery complications.

Background: Administrative data are increasingly used to track surgical outcomes.

Methods: All patients undergoing thyroid surgery at three French university hospitals between April 2008 and April 2009 were prospectively included. Read More

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December 2018
1 Read

How radical is total parathyroidectomy in patients with renal hyperparathyroidism?

Langenbecks Arch Surg 2018 Dec 5. Epub 2018 Dec 5.

Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Waehringer Gürtel 18-20, A-1090, Vienna, Austria.

Purpose: Total parathyroidectomy (tPTX) in patients with renal hyperparathyroidism (RHPT) aims at the complete removal of all hyperfunctioning parathyroid tissue. Whenever parathyroidectomy is termed "total," undetectable postoperative parathyroid hormone (PTH) levels within the first postoperative week are expected. The aim of this study was to evaluate if tPTX is technically possible using a radical surgical procedure. Read More

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December 2018

Assessing the Efficacy of Ventilation of Anesthetized Neonatal Calves Using a Laryngeal Mask Airway or Mask Resuscitator.

Front Vet Sci 2018 21;5:292. Epub 2018 Nov 21.

Department of Production Animal Health, University of Calgary Faculty of Veterinary Medicine, Calgary, AB, Canada.

Calves that have undergone a dystocia are often hypoxic and acidemic, which can result in reduced vigor and subsequent mortality. Methods of field resuscitation of apneic newborn calves are often ineffective and therefore underutilized. This proof-of-concept study aimed to determine the efficacy of the laryngeal mask airway (LMA) as well as the current industry standard method of ventilation, the McCulloch Calf Aspirator/ Resuscitator (MMR) for positive pressure ventilation of neonatal calves. Read More

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November 2018

Identification of Integrin β1 as a Novel PAG1-Interacting Protein Involved in the Inherent Radioresistance of Human Laryngeal Carcinoma.

J Cancer 2018 18;9(22):4128-4138. Epub 2018 Oct 18.

Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.

Inherent radioresistance plays a crucial role in the failure of radiotherapy. Using the inherent radioresistant (Hep-2max) and radiosensitive (Hep-2min) cell lines established from the parental cell line Hep-2, we previously reported that phosphoprotein associated with glycosphingolipid-enriched microdomains 1(PAG1) overexpression in laryngeal carcinoma cells was correlated with inherent radioresistant phenotypes. However, the underlying mechanisms of this effect remain unknown. Read More

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October 2018

Impact of the anterior commissure involvement on the survival of early glottic cancer treated with cricohyoidoepiglottopexy: a retrospective study.

Cancer Manag Res 2018 8;10:5553-5558. Epub 2018 Nov 8.

Otolaryngology, Department of Health Sciences, University of Catanzaro, Catanzaro, Italy,

Background: Laryngeal early glottic tumors can benefit from different treatment modalities, including transoral laser microsurgery, open partial horizontal laryngectomy (OPHL), and radiotherapy. However, the treatment of early glottic tumors with the involvement of the anterior commissure remains controversial. The studies about the role of anterior commissure involvement in oncologic outcomes in patients with early glottic cancer treated with supracricoid laryngectomy (SCL) are very few. Read More

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November 2018

Effects of fascia iliaca compartment block combined with general laryngeal mask airway anesthesia in children undergoing femoral fracture surgery: a randomized trial.

J Pain Res 2018 8;11:2821-2826. Epub 2018 Nov 8.

School of Medicine, Jiaxing University, Jiaxing 314000, Zhejiang, China,

Background: Postoperative agitation after general anesthesia is a common complication in children; however, pain or uncomfortable feeling is the main reason of emergence agitation. Here, we have investigated the effects of fascia iliaca compartment block (FICB) combined with general laryngeal mask airway (LMA) anesthesia in children undergoing femoral surgery.

Methods: Eighty children undergoing femoral surgery were randomly divided into two groups: FICB + LMA group and control group (n=40). Read More

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November 2018

Matched-pair analysis of survival in the patients with T3 laryngeal squamous cell carcinoma treated with supracricoid partial laryngectomy or total laryngectomy.

Onco Targets Ther 2018 9;11:7947-7953. Epub 2018 Nov 9.

Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China,

Background: The survival outcomes between supracricoid partial laryngectomy (SCPL) and total laryngectomy (TL) were compared in the groups of matched-pair patients with T3 laryngeal squamous cell carcinoma (LSCC).

Methods: Patients with T3 LSCC were matched based on prognostic factors. The Kaplan-Meier curve and the Cox proportional hazards model were used for analysis on survival. Read More

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November 2018

Supraglottic airway devices for surfactant treatment: systematic review and meta-analysis.

J Perinatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Woman's and Child's Health, University of Padova, Padova, Italy.

Objective: To compare surfactant administration via supraglottic airway device (SAD) vs. nasal CPAP alone or INSURE.

Study Design: A systematic search of PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Clinicaltrials. Read More

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December 2018
1 Read

Salvage laryngectomy and laryngopharyngectomy: A multicenter review of outcomes associated with a reconstructive approach: Microvascular Committee of the American Academy of Otolaryngology-Head & Neck Surgery.

Head Neck 2018 Dec 3. Epub 2018 Dec 3.

University of Toronto, Faculty of Medicine, Department of Otolaryngology - Head and Neck Surgery, 200 Elizabeth Street, 8th Floor 8NU 881, Toronto, Ontario, Canada M5G 2C4.

Background: Surgeons have developed various reconstructive techniques to minimize the rate of pharyngocutaneous fistula and optimize functional outcome after salvage laryngectomy or laryngopharyngectomy.

Methods: Multicenter retrospective review at 33 institutions of 486 patients with a history of squamous cell carcinoma (SCC) of the larynx or hypopharynx previously treated with primary chemoradiotherapy (CRT) who required salvage surgery. Outcomes evaluated were overall fistula rate, fistula requiring reoperation, and 12-month speech and swallowing function. Read More

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December 2018

Overexpression of lncRNA snaR is correlated with progression and predicts poor survival of laryngeal squamous cell carcinoma.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, China.

Long noncoding RNAs (lncRNA) snaR is a characterized oncogenic lncRNA in triple negative breast cancer and ovarian cancer, while its role in other human diseases is unknown. In the present study, we found that plasma levels of snaR were upregulated in patients with laryngeal squamous cell carcinoma (LSCC) than in healthy controls. Plasma levels of snaR increased with increase in AJCC stages. Read More

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December 2018

Outcome and toxicity of intensity-modulated radiotherapy with simultaneous integrated boost in patients with pharyngo-laryngeal cancer.

Clin Transl Oncol 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiation Oncology, GenesisCare, Madrid, Spain.

Purpose: The present work aims at evaluating intensity-modulated radiation therapy with simultaneous integrated boost (IMRT-SIB) in squamous cell carcinomas (SCC) of the larynx and hypopharynx.

Methods/patients: We performed a single institutional retrospective analysis on 116 pharyngo (29%)-laryngeal (71%) SCC patients (93% male) treated with IMRT-SIB to 66-69.96 Gy in 33 fractions between 2008 and 2016. Read More

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November 2018

Validation of ultrasound as a diagnostic tool to assess vocal cord motion in an animal feasibility study.

Gland Surg 2018 Oct;7(5):433-439

Department of Otolaryngology, Head and Neck Surgery, University of Tennessee Health Science Center, Memphis, TN, USA.

Background: Post-thyroidectomy dysphonia can result from recurrent laryngeal nerve (RLN) injury. Confirmation of postoperative recurrent nerve function has prompted many surgeons to advocate laryngoscopic examination. Indirect and flexible laryngoscopy permit visualization of vocal cord motion, but not all thyroid surgeons are skilled in these techniques. Read More

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October 2018
1 Read

Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Objective: The study objective was to determine risk factors for severity of juvenile-onset recurrent respiratory papillomatosis (RRP) at first endoscopic evaluation.

Methods: Based on a review of all cases undergoing surgery for juvenile-onset RRP in two pediatric otolaryngology departments in the USA and France, the following severity risk factors were analyzed: number of laryngeal levels involved, extension to the subglottis, and bilateral involvement.

Results: Thirty-two patients were included, with 571 endoscopic procedures. Read More

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November 2018
1 Read

Biobehavioral Measures of Presbylaryngeus.

J Voice 2018 Nov 29. Epub 2018 Nov 29.

Division of Communication Sciences and Disorders, University of Kentucky, Lexington, Kentucky.

Objective: The objective of this observational study was to assess the relationship between established aging biobehavioral measures and voice decline in normally aging adults.

Study Design: Cross-sectional study.

Methods: Participants 60-85 years of age were divided into two age and sex-matched groups, based on the presence or absence of presbylaryngeus. Read More

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November 2018

Magnetic resonance-based volumetric measurement of the endolymphatic space in patients with Meniere's disease and other endolymphatic hydrops-related diseases.

Auris Nasus Larynx 2018 Nov 29. Epub 2018 Nov 29.

Department of Otorhinolaryngology Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara, Japan.

Objective: To employ magnetic resonance imaging (MRI) to measure the volume of the inner ear endolymphatic space (ELS) in patients with acute low-tone sensorineural hearing loss (ALHL), sudden deafness (SD), cochlear Meniere's disease (cMD), and unilateral MD (uMD) compared with control subjects (CS) with chronic rhinosinusitis.

Methods: Forty-one patients with ALHL, 82 with SD, 48 with cMD, 72 with uMD, and 47 CS participated in the study. With the exception of all uMD patients, none of the subjects had vertigo. Read More

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November 2018
1 Read

Role of phosphorylcholine in Streptococcus pneumoniae and nontypeable Haemophilus influenzae adherence to epithelial cells.

Auris Nasus Larynx 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Objective: Phosphorylcholine (PC) is a structural component of Streptococcus pneumoniae (Spn) and nontypeable Haemophilus influenzae (NTHi), and is known to be associated with adherence through the platelet activating factor receptor (PAF-R). Furthermore, high PC expression is considered to be involved in Spn and NTHi virulence. In this study, we examined the influence of PC expression on the adherence of Spn and NTHi to epithelial cells in order to clarify the potential effectiveness of a vaccine targeting PC. Read More

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November 2018

Laryngeal stenosis in children: Types, grades and treatment strategies.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Pediatric Surgery Division, Hospital Universitario 12 de Octubre, Avda. De Córdoba s/n, Madrid 28041, Spain.

Introduction: Laryngeal stenosis is infrequent in children and usually secondary to endotracheal intubation. The aims of this study were to review the outcomes of the distinct endoscopic and surgical procedures and to suggest a technical modification for one of them.

Methods: Retrospective review of patients with the diagnosis of laryngeal stenosis treated in an academic tertiary care institution between 2000 and 2017. Read More

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November 2018

Change in endolymphatic hydrops 2 years after endolymphatic sac surgery evaluated by MRI.

Auris Nasus Larynx 2018 Nov 27. Epub 2018 Nov 27.

Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: This study was performed to determine whether endolymphatic sac surgery improves vestibular and cochlear endolymphatic hydrops 2 years after sac surgery and to elucidate the relationship between the degree of improvement of endolymphatic hydrops and the changes in vertigo symptoms, the hearing level, and the summating potential/action potential ratio (-SP/AP ratio) by electrocochleography (ECochG) in patients with Ménière's disease (MD).

Methods: Twenty-one patients with unilateral MD who underwent sac surgery were included in this study. All patients underwent gadolinium-enhanced magnetic resonance imaging (Gd-MRI) before and 2 years after sac surgery. Read More

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November 2018
1 Read

Meta-analysis Comparison of Bilateral Axillo-Breast Approach Robotic Thyroidectomy and Conventional Thyroidectomy.

Surg Innov 2018 Dec 3:1553350618817145. Epub 2018 Dec 3.

1 Department of Surgery, The Second Hospital of Shandong University, Jinan, Shandong, China.

Objective: Despite gaining popularity, bilateral axillo-breast approach robotic thyroidectomy (BABA RT) remains controversial. We performed a meta-analysis to evaluate the safety and effectiveness of BABA RT compared with open thyroidectomy (OT) in thyroid disease.

Methods: A literature search was conducted using various databases, including PubMed, Web of Science, and Cochrane Library, up to February 2018. Read More

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December 2018
2 Reads

Treatment of psychiatric disturbances in common hyperkinetic movement disorders.

Expert Rev Neurother 2018 Dec 1. Epub 2018 Dec 1.

b Department of Human Neurosciences , Sapienza University of Rome , Rome.

Introduction: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's disease and essential tremor. Areas covered: We searched for papers in English in Pubmed using the following keywords: blepharospasm, cervical dystonia, arm dystonia, laryngeal dystonia, spasmodic dysphonia, tic disorders, Tourette syndrome, Huntington's chorea, essential tremor, depression, anxiety, obsessive compulsive disorders, attention deficit hyperactivity disorders, psychosis, apathy. Expert commentary: Although psychiatric disturbances are frequent in hyperkinetic movement disorders, few controlled studies have assessed the treatment of psychiatric disturbances in such disorders. Read More

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December 2018
2 Reads

Level VI lymph nodes: an anatomic study of lymph nodes located between the recurrent laryngeal nerve and the right common carotid artery.

Rev Col Bras Cir 2018 Nov 29;45(6):e1972. Epub 2018 Nov 29.

Universidade de São Paulo, Faculdade de Medicina, Disciplina de Topografia Estrutural Humana, São Paulo, SP, Brasil.

Objective: to describe the presence of lymph nodes and their relationships with demographic and anthropometric characteristics in a specific region, not yet described in anatomy compendiums, called by us Recurrent Carotid Recess (RCR) and located among the right recurrent laryngeal nerve, the right common carotid artery, and the right inferior thyroid artery.

Methods: 32 right cervical regions were harvested from cadavers within 24 hours post-mortem. The fibro-fatty tissue of the RCR was resected and prepared with formalin fixation. Read More

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November 2018

Risk factors for acute unplanned tracheostomy during panendoscopy in HNSCC patients.

PLoS One 2018 5;13(12):e0207171. Epub 2018 Dec 5.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.

Background: Despite of careful pre-operative risk evaluation some patients require an acute unplanned tracheostomy during panendoscopy.

Methods: Risk factors of patients requiring an unplanned tracheostomy during panendoscopy (n = 32) were compared to a control group with panendoscopy without tracheostomy (n = 180).

Results: 2131 panendoscopies for Head and Neck squamous cell carcinoma were performed at our Department between 2000 and 2014. Read More

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December 2018
7 Reads

Using a Sternocleidomastoid Muscle Flap to Close an Iatrogenic Tracheoesophageal Fistula in a Patient With Advanced Laryngeal Cancer: A Case Report and Literature Review.

Ann Plast Surg 2018 Dec 3. Epub 2018 Dec 3.

From the Department of Plastic Surgery, Mackay Memorial Hospital, Taipei, Taiwan.

Background: An iatrogenic tracheoesophageal (TE) fistula is one possible complication after total laryngectomy with flap reconstruction. We used sternocleidomastoid (SCM) rotation flap to close a TE fistula.

Methods And Results: A 69-year-old man with laryngeal cancer underwent total laryngectomy with radial forearm free flap reconstruction. Read More

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December 2018

Maxillofacial Fractures Associated With Laryngeal Injury: A Craniofacial Surgeon Should be Alert.

Ann Plast Surg 2018 Dec 3. Epub 2018 Dec 3.

From the Departments of Plastic and Reconstructive Surgery and.

Objective: Maxillofacial fractures with concomitant laryngeal injuries put both the quality and maintenance of life in jeopardy. Because of its low incidence, it is often overlooked in the clinical setting. The purpose of this study is to review the incidence, clinical presentations, managements, and outcomes of these patients. Read More

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December 2018

Omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma was safe and feasible, and improved patient-reported voice outcomes.

Clin Transl Oncol 2018 Dec 4. Epub 2018 Dec 4.

Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Background: Worsening voice and speech quality was frequently reported in head-and-neck patients after radiotherapy to the neck; omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma (NPC) patients might be safe and feasible, and improve voice and speech outcomes.

Methods: From January 2009 to January 2013, 71 patients were analyzed. All patients received bilateral neck irradiation. Read More

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December 2018
3 Reads

Expression levels of miR-34-family microRNAs are associated with TP53 mutation status in head and neck squamous cell carcinoma.

Eur Arch Otorhinolaryngol 2018 Dec 4. Epub 2018 Dec 4.

Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Purpose: The majority of head and neck squamous cell carcinoma (HNSCC) cases in developing countries are associated with cigarette smoking and TP53 mutations. p53 is a transcription factor that activates downstream genes, including the hsa-miR-34a and hsa-miR-34b/c loci, to achieve cell-cycle arrest, senescence, and/or apoptosis. This study examined the differences in expression levels of miR-34 in HNSCC with or without TP53 mutations. Read More

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December 2018

Individualized Patient Vocal Priorities for Tailored Therapy.

J Speech Lang Hear Res 2018 Dec 4:1-11. Epub 2018 Dec 4.

Clinical Center for Voice Care, Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas.

Purpose: The purposes of this study are to introduce the concept of vocal priorities based on acoustic correlates, to develop an instrument to determine these vocal priorities, and to analyze the pattern of vocal priorities in patients with voice disorders.

Method: Questions probing the importance of 5 vocal attributes (vocal clarity, loudness, mean speaking pitch, pitch range, vocal endurance) were generated from consensus conference involving speech-language pathologists, laryngologists, and voice scientists, as well as patient feedback. The responses to the preliminary items from 213 subjects were subjected to exploratory factor analysis, which confirmed 4 of the predefined domains. Read More

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December 2018
3 Reads

Inhibition of autophagy by chloroquine makes chemotherapy in nasopharyngeal carcinoma more efficient.

Auris Nasus Larynx 2018 Dec 1. Epub 2018 Dec 1.

Division of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan. Electronic address:

Objectives: A combination of platinum-based chemotherapy and radiotherapy is the standard treatment for nasopharyngeal carcinoma (NPC). However, the efficacy of chemotherapy has reached a plateau. Many autophagy studies suggest that autophagy can either promote or suppress to cancer progression. Read More

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December 2018

Pyogenic granuloma of the larynx: A rare cause of hemoptysis.

Am J Otolaryngol 2018 Oct 29. Epub 2018 Oct 29.

Head and Neck Institute, Cleveland Clinic, Cleveland, OH, USA.

Pyogenic granuloma (PG) may involve gingival mucosa (granuloma gravidarum) in pregnancy but rarely involves the airway. This case report is perhaps the only reported presentation of PG in the larynx causing hemoptysis at a late stage of pregnancy. On laryngoscopic exam, a vascular, right false vocal fold neoplasm was identified with pathological characteristics consistent with PG. Read More

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October 2018

Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study.

J Otolaryngol Head Neck Surg 2018 Dec 4;47(1):74. Epub 2018 Dec 4.

Department of Otolaryngology, Head and Neck Surgery, University of Ottawa, 501 Smyth Rd, Module S - Room M2566, Box 216, Ottawa, ON, K1H 8L6, Canada.

Background: We sought to expand upon preliminary data suggesting that metformin confers a survival benefit to patients with head and neck squamous cell carcinoma (HNSCC).

Methods: A large-scale retrospective cohort study of all patients in Ontario diagnosed with squamous cancer of the larynx, hypopharynx, and nasopharynx between Dec 1st 2007 to Dec 1st 2012 was undertaken. The Institute for Clinical and Evaluative Sciences was accessed to obtain patient demographic, treatment and outcome information. Read More

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December 2018

A Targeted Swallow Screen for the Detection of Postoperative Dysphagia in Liver Transplant Patients.

Prog Transplant 2018 Dec 4:1526924818817035. Epub 2018 Dec 4.

1 Division of Cardiac Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Introduction:: Postoperative dysphagia leads to aspiration pneumonia, prolonged hospital stay, and is associated with increased mortality. We have demonstrated the validity of a bedside targeted swallow evaluation following cardiac surgery. Since dysphagia following liver transplantation is not well examined, we evaluated the efficacy of this swallow screen method in postoperative liver transplant patients. Read More

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December 2018

A phrase captures aerodynamic and acoustic data in healthy voice users and in patients with voice disorders.

Logoped Phoniatr Vocol 2018 Dec 4:1-6. Epub 2018 Dec 4.

a Department of Communication Sciences and Disorders , West Chester University , West Chester , PA , USA.

Purpose: A voice evaluation typically involves aerodynamic and acoustic measures captured through repeated /pi/s. The current study addresses the need for a more functional utterance that better approximates connected speech.

Methods: Healthy voice users and patients with voice disorders produced repeated /pi/s and a phrase, "Pooh, pay Pia pea pie," into the Phonatory Aerodynamic System across two trials. Read More

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December 2018
1 Read

The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Head and Neck Cancer Patients Treated with Radiotherapy.

J Clin Med 2018 Dec 3;7(12). Epub 2018 Dec 3.

Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.

Background: To investigate the prognostic value of pre-treatment neutrophil/lymphocyte ratio (NLR) in patients treated with definitive radiotherapy (RT) for head and neck cancer.

Methods: We retrospectively analyzed 621 patients who received definitive RT for nasopharyngeal, oropharyngeal, hypopharyngeal, and laryngeal cancer. An NLR cut-off value of 2. Read More

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December 2018

DNA replication licensing proteins: Saints and sinners in cancer.

Semin Cancer Biol 2018 Nov 28. Epub 2018 Nov 28.

Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau. Electronic address:

DNA replication is all-or-none process in the cell, meaning, once the DNA replication begins it proceeds to completion. Hence, to achieve maximum control of DNA replication, eukaryotic cells employ a multi-subunit initiator protein complex known as "pre-replication complex or DNA replication licensing complex (DNA replication LC). This complex involves multiple proteins which are origin-recognition complex family proteins, cell division cycle-6, chromatin licensing and DNA replication factor 1, and minichromosome maintenance family proteins. Read More

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November 2018
4 Reads

Tuberculous neck lymphadenopathy: a diagnostic challenge.

J Stomatol Oral Maxillofac Surg 2018 Dec 1. Epub 2018 Dec 1.

Division of Otorhinolaryngology, University of Eastern Piedmont, Novara, Italy.

Tuberculosis (TB) continues to be a major health problem for the developing world and a a rise in the number of cases has been noted in the western hemisphere too. TB can affect most organs in the head and neck region, such as the lymph nodes, larynx, middle ear, oral cavity and pharynx. In particular, as for cervical tuberculosis lymphadenopathy, a predominant involvement of the posterior triangle, supraclavicular, and internal jugular group of nodes bilaterally can be observed. Read More

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December 2018
1 Read

Predicting laryngeal exposure in microlaryngoscopy: External validation of the laryngoscore.

Laryngoscope 2018 Dec 3. Epub 2018 Dec 3.

ENT Clinic, Head and Neck Department, Trieste, Italy.

Objectives: Optimal laryngeal exposure during transoral laryngeal surgery is fundamental. We aimed to evaluate the reliability of a recently proposed score (Laryngoscore) in predicting difficult laryngeal exposure (DLE) in an independent cohort of patients undergoing elective microlaryngoscopy. We also verified the relation between DLE, surgeon's expertise, and difficult intubation, and investigated possible areas for score improvement. Read More

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December 2018

How does neural monitoring help during thyroid sugery for Graves' disease?

J Clin Transl Endocrinol 2019 Mar 20;15:6-11. Epub 2018 Nov 20.

Division of Head and Neck Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

We evaluate the role of intraoperative neuromonitoring (IONM) in thyroidectomy performed for Graves' disease (GD) with an emphasis on recurrent laryngeal nerve (RLN) management and completeness of resection. The study is a retrospective series comprising 55 thyroidectomy (control group) versus 82 procedures with intermittent IONM (I-IONM) and 72 by means of continuous IONM (C-IONM). In the control group the laryngeal nerves have been identified by visualization solely. Read More

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An Unusual Finding of the Hyoid Bone.

Cureus 2018 Sep 26;10(9):e3365. Epub 2018 Sep 26.

Neurosurgery, Seattle Science Foundation, Seattle, USA.

The hyoid contributes to many biomechanical processes including swallowing. Additionally, the hyoid bone has been studied for over a century in an effort to catalog and categorize many observed biometric differences. This has led to the hyoid being a major structure involved in forensic pathology. Read More

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September 2018

Stridor-related gray matter alterations in multiple system atrophy: A pilot study.

Parkinsonism Relat Disord 2018 Nov 17. Epub 2018 Nov 17.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna, Clinica Neurologica, Bologna, Italy.

Introduction: The neuroanatomical substrate of stridor associated with Multiple System Atrophy (MSA) remains unclear. We evaluated stridor-related gray matter (GM) changes in MSA.

Methods: 36 MSA patients underwent standardized nocturnal video-polysomnography and brain MRI. Read More

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November 2018
2 Reads

Foreign bodies in the ear, nose, and throat in Japan: association with sociocultural and geographical conditions.

Auris Nasus Larynx 2018 Nov 30. Epub 2018 Nov 30.

Department of Otorhinolaryngology Head and Neck surgery, Osaka University Graduate School of Medicine, 2-15 Yamadaoka, Suita-shi, Osaka, Japan.

Objective: Foreign bodies (FBs) in ear, nose, and throat (ENT) are common ENT emergencies but are sometimes life-threatening. However, FBs could be avoidable by the efficient announcement about the risk of these occurrence to the public. Fish bones are commonly found as throat FBs, and small toys are commonly found as pediatric ear and nose FBs. Read More

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November 2018

[The cardiovocal syndrome].

Ugeskr Laeger 2018 Nov;180(47)

Ortner's syndrome, also known as the cardiovocal syndrome, refers to left recurrent laryngeal nerve palsy and hereby hoarseness due to cardiovascular disease. The palsy arises from compression of the nerve, as it passes between the aortic arch and the pulmonary artery. This case report describes a patient, who presented with hoarseness and recurrent laryngeal nerve palsy due to an 8 × 7. Read More

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November 2018

Surgical and pathological outcomes of elective neck dissection during salvage total laryngectomy.

Clin Otolaryngol 2018 Nov 30. Epub 2018 Nov 30.

Department of Otolaryngology, Head& Neck Surgery, Edinburgh Cancer Centre, Western General Hospital, Edinburgh.

The rate of occult nodal metastases during primary laryngectomy with no clinical or radiological evidence of neck disease (cN0) has been found to be as high as 20%. Therefore, bilateral elective neck dissection is usually recommended. However, the role of neck dissection in the salvage laryngectomy setting remains unclear. Read More

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November 2018
2 Reads

Functional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation.

Brain Res 2018 Nov 27. Epub 2018 Nov 27.

Departments of Psychiatry, Neuroscience, and Comparative Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Medical Physics and Biomedical Engineering, University College London, UK.

Previous studies in animals and humans suggest the periaqueductal grey region (PAG) is a final integration station between the brain and laryngeal musculature during phonation. To date, a limited number of functional magnetic neuroimaging (fMRI) studies have examined the functional connectivity of the PAG during volitional human phonation. An event-related, stimulus-induced, volitional movement paradigm was used to examine neural activity during sustained vocalization in neurologically healthy adults and was compared to controlled exhalation through the nose. Read More

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November 2018
4 Reads

Data Set for the Reporting of Carcinomas of the Hypopharynx, Larynx, and Trachea: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting (ICCR).

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Cellular Pathology, University of Liverpool, Liverpool, United Kingdom (Dr Helliwell); the Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri (Dr Chernock); ANU College of Health and Medicine, Anatomical Pathology, ACT Pathology, Canberra Hospital, Woden, Australia (Dr Dahlstrom); Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia (Drs Gale and Zidar); the Department of Pathology, Michigan Medicine - University of Michigan, Ann Arbor (Dr McHugh); the Department of Anatomic Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada (Dr Perez-Ordoñez); the Department of ENT-Head and Neck Surgery, University Hospital Aintree, Liverpool, United Kingdom (Dr Roland); and the Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills (Dr Thompson).

The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Standardized pathologic reporting for cancers facilitates improved communication for patient care and prognosis and the comparison of data between countries to progressively improve clinical outcomes. Laryngeal cancers are often accompanied by significant morbidity, although surgical advances (such as transoral endoscopic laser microresection and transoral robotic surgery) provide new alternatives. Read More

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November 2018
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Data Set for the Reporting of Nodal Excisions and Neck Dissection Specimens for Head and Neck Tumors: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting (ICCR).

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (Dr Bullock); the Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia (Dr Beitler); the Pathology and Laboratory Medicine Institute, Cleveland Clinic, Weston, Florida (Dr Carlson); the Instituto de Anatomia Patológica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal (Dr Fonseca); the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock (Dr Hunt); the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Katabi); the Department of Cellular Pathology, Newcastle University, Newcastle upon Tyne, United Kingdom (Dr Sloan); the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada (Dr Taylor); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Williams); and the Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, California (Dr Thompson).

Standardized, synoptic pathologic reporting for tumors greatly improves communication among clinicians, patients, and researchers, supporting prognostication and comparison about patient outcomes across institutions and countries. The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Within the head and neck region, lymph node excisions and neck dissections are frequently performed as part of the management of head and neck cancers arising from the mucosal sites (sinonasal tract, nasopharynx, oropharynx, hypopharynx, oral cavity, and larynx), along with bone tumors, skin cancers, melanomas, and other tumor categories. Read More

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November 2018