1,778 results match your criteria Laryngeal Carcinoma Imaging


Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.

J Clin Oncol 2020 Jun 1:JCO1903156. Epub 2020 Jun 1.

Sanford Cancer Center, Sanford Health, Sioux Falls, SD.

Purpose: Pembrolizumab is a humanized monoclonal antibody that blocks interaction between programmed death receptor-1 (PD-1) and its ligands (PD-L1, PD-L2). Although pembrolizumab is approved for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), its role in the management of locally advanced (LA) disease is not defined. We report a phase IB study evaluating the safety and efficacy of adding pembrolizumab to cisplatin-based chemoradiotherapy in patients with LA HNSCC. Read More

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http://dx.doi.org/10.1200/JCO.19.03156DOI Listing

Hyperspectral Microscopic Imaging for Automatic Detection of Head and Neck Squamous Cell Carcinoma Using Histologic Image and Machine Learning.

Proc SPIE Int Soc Opt Eng 2020 Feb 16;11320. Epub 2020 Mar 16.

Univ. of Texas at Dallas, Department of Bioengineering, Richardson, TX 75080.

The purpose of this study is to develop hyperspectral imaging (HSI) for automatic detection of head and neck cancer cells on histologic slides. A compact hyperspectral microscopic system is developed in this study. Histologic slides from 15 patients with squamous cell carcinoma (SCC) of the larynx and hypopharynx are imaged with the system. Read More

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http://dx.doi.org/10.1117/12.2549369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261606PMC
February 2020

Current role of computed tomography imaging in the evaluation of cartilage invasion by laryngeal carcinoma.

Radiol Med 2020 May 15. Epub 2020 May 15.

Department of Radiology, Careggi University Hospital, Viale Morgagni 85, 50134, Florence, Italy.

Objectives: To evaluate thyroid, arytenoid, and cricoid cartilage invasion on computed tomography (CT) imaging in patients undergoing total laryngectomy for both primary and recurrent laryngeal carcinoma. Secondary endpoint was to compare laryngeal cartilage invasion between primary and recurrent tumours.

Methods: Pre-treatment CT of 40 patients who had undergone total laryngectomy was retrospectively evaluated and compared with histology. Read More

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http://dx.doi.org/10.1007/s11547-020-01213-yDOI Listing

Fluorescence imaging-guided multifunctional liposomes for tumor-specific phototherapy for laryngeal carcinoma.

Biomater Sci 2020 Jun 15;8(12):3443-3453. Epub 2020 May 15.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.

Reliable diagnosis and efficient targeted therapy are important and may lead to the effective treatment of laryngeal carcinoma. Multifunctional nano-theranostic agents demonstrate great potential in tumor theranostic applications. Thus, herein, we report novel targeting multifunctional theranostic nanoparticles, internalized RGD (iRGD)-modified indocyanine green (ICG) encapsulated liposomes (iLIP), for imaging-guided photothermal therapy (PTT) and photodynamic therapy (PDT) for the treatment of laryngeal carcinoma. Read More

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http://dx.doi.org/10.1039/d0bm00249fDOI Listing

[Modern thyroid surgery - the surgeon's endocrine-surgical understanding and his responsibility for the extent of surgery and complication rate].

Wien Med Wochenschr 2020 Apr 27. Epub 2020 Apr 27.

Chirurgie, Sanatorium Kettenbrücke der Barmherzigen Schwestern, Sennstraße 1, 6020, Innsbruck, Österreich.

High quality thyroid surgery implies a surgeon with an endocrine-surgical understanding aiming at best possible outcome. This includes an appropriate extent of the resection and a low rate of complications. It is important that the surgeon is involved at an early stage being part of the decision process for or against partial or total thyroidectomy. Read More

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http://dx.doi.org/10.1007/s10354-020-00750-5DOI Listing

Evaluation of CT-based radiomics signature and nomogram as prognostic markers in patients with laryngeal squamous cell carcinoma.

Cancer Imaging 2020 Apr 22;20(1):28. Epub 2020 Apr 22.

Department of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center, No.37, Guoxue Alley, Chengdu, 610041, People's Republic of China.

Background: The aim of this study was to evaluate the prognostic value of radiomics signature and nomogram based on contrast-enhanced computed tomography (CT) in patients after surgical resection of laryngeal squamous cell carcinoma (LSCC).

Methods: All patients (n = 136) were divided into the training cohort (n = 96) and validation cohort (n = 40). The LASSO regression method was performed to construct radiomics signature from CT texture features. Read More

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http://dx.doi.org/10.1186/s40644-020-00310-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178759PMC
April 2020
1.286 Impact Factor

Diagnosis and treatment of HEp-2 cells contaminated with mycoplasma.

Braz J Biol 2020 Apr 22. Epub 2020 Apr 22.

Departamento de Ciências Biológicas, Faculdade de Ciências e Letras, Universidade Estadual Paulista - UNESP, Av. Dom Antônio, 2100, Parque Universitário, CEP 19806-900, Assis, SP, Brasil.

Contamination of primary and cell cultures by mycoplasmas is one of the main economic and biological pitfalls in basic research, diagnosis and manufacture of biotechnological products. It is a common issue which may be difficult to conduct surveillance on. Mycoplasma presence may affect several physiological parameters of the cell, besides being considered an important source of inaccurate and/or non-reproducible scientific results. Read More

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http://dx.doi.org/10.1590/1519-6984.215721DOI Listing

Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells.

Front Pharmacol 2020 13;11:263. Epub 2020 Mar 13.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.

The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradiotherapy, but recurrences often occur that are associated with radioresistance. Using human SQD9 laryngeal squamous cell carcinoma cancer cells as a model, we aimed to identify metabolic changes associated with acquired radioresistance. In a top-down approach, matched radiosensitive and radioresistant SQD9 cells were generated and metabolically compared, focusing on glycolysis, oxidative phosphorylation (OXPHOS) and ROS production. Read More

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http://dx.doi.org/10.3389/fphar.2020.00263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082361PMC

Safety of percutaneous ultrasound-guided fine-needle aspiration of adrenal lesions in dogs: Perception of the procedure by radiologists and presentation of 50 cases.

J Vet Intern Med 2020 Mar 11;34(2):626-635. Epub 2020 Mar 11.

Department of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Background: Percutaneous ultrasound (US)-guided fine-needle aspiration (FNA) of adrenal gland lesions is controversial in veterinary medicine.

Objective: To evaluate the frequency and radiologists' perception of the risk of the procedure as well as determining the incidence of complications.

Methods: Retrospective study. Read More

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http://dx.doi.org/10.1111/jvim.15743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096638PMC

Tumor radiomic features complement clinico-radiological factors in predicting long-term local control and laryngectomy free survival in locally advanced laryngo-pharyngeal cancers.

Br J Radiol 2020 May 26;93(1109):20190857. Epub 2020 Feb 26.

Institute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, UK.

Objective: To study if pre-treatment CT texture features in locally advanced squamous cell carcinoma of laryngo-pharynx can predict long-term local control and laryngectomy free survival (LFS).

Methods: Image texture features of 60 patients treated with chemoradiation (CTRT) within an ethically approved study were studied on contrast-enhanced images using a texture analysis research software (TexRad, UK). A filtration-histogram technique was used where the filtration step extracted and enhanced features of different sizes and intensity variations corresponding to a particular spatial scale filter (SSF): SSF = 0 (without filtration), SSF = 2 mm (fine texture), SSF = 3-5 mm (medium texture) and SSF = 6 mm (coarse texture). Read More

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http://dx.doi.org/10.1259/bjr.20190857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217564PMC

Real-time imaging of head and neck squamous cell carcinomas using confocal micro-endoscopy and applicable dye: A preliminary study.

Auris Nasus Larynx 2020 Feb 20. Epub 2020 Feb 20.

Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu 514-8507, Japan.

Objectives: Confocal laser endomicroscopy (CLE) is a technology that enables microscopic visualization of lesions in real-time (optical biopsy) and has been successfully applied for clinical use in gastroenterology. Recently, it was also introduced for head and neck squamous cell carcinoma (HNSCC) diagnostics. We previously designed a self-made CLE, which can provide bichrome images, with topical contrast agents that are safe for use in patients. Read More

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http://dx.doi.org/10.1016/j.anl.2020.02.001DOI Listing
February 2020

Superiority of NBI endoscopy to PET/CT scan in detecting esophageal cancer among head and neck cancer patients: a retrospective cohort analysis.

BMC Cancer 2020 Jan 29;20(1):69. Epub 2020 Jan 29.

Endoscopy Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, Taiwan.

Background: Second primary cancer of the esophagus is frequent in head and neck patients, especially in high-risk populations, and has a great impact on the prognosis. Although Positron emission tomography (PET)/computed tomography (CT) scan is commonly conducted in head and neck patients, its ability to detect early esophageal cancer is limited. Narrow-band imaging endoscopy is an accurate and convenient technique for esophageal examination. Read More

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http://dx.doi.org/10.1186/s12885-020-6558-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988258PMC
January 2020

Metastatic large cell neuroendocrine carcinoma of larynx: Individualizing tumor biology by dual tracer positron emission tomography/computed tomography (Ga-DOTATATE and F-fluorodeoxyglucose) molecular imaging and disease stabilization following Lu-DOTATATE peptide receptor radionuclide therapy after initial progression on chemoradiotherapy.

World J Nucl Med 2019 Oct-Dec;18(4):431-433. Epub 2019 Dec 18.

Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra, India.

Debate exists on the disease biology and course of primary large cell neuroendocrine carcinoma (LCNEC) of larynx, being classified as a variant of atypical carcinoid by the World Health Organisation-2005 classification, while literature of its aggressive behavior indicating poorly differentiated neuroendocrine carcinoma (akin to pulmonary LCNEC) exists. The utility of dual tracer positron emission tomography/computed tomography (Ga-DOTATATE and F-fluorodeoxyglucose) in deciphering the dynamic tumor biology and feasibility of peptide receptor radionuclide therapy (PRRT) is illustrated in metastatic LCNEC of epiglottis after disease progression following conventional chemoradiotherapy. Relatively, atypical sites of soft-tissue metastases (subcutaneous tissue of arm, scrotal sac, peritoneum, and lamina of thyroid cartilage) and xiphisternum and disease stabilization following Lu-DOTATATE PRRT were other noteworthy unique aspects of this report. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_76_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945362PMC
December 2019

Diagnosis and Monitoring Value of Diffusion-Weighted Magnetic Resonance Imaging Using Neuroendocrine Analysis During Radiotherapy for Laryngeal Cancer.

World Neurosurg 2020 Jun 10;138:696-705. Epub 2020 Jan 10.

Cancer Center, Affiliated Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, China. Electronic address:

We used 1.5T magnetic resonance imaging (MRI) to investigate the role of semiquantitative parameters related to dynamic contrast-enhanced (DCE)-MRI and the apparent diffusion coefficient (ADC) of diffusion-weighted imaging (DWI) in predicting and monitoring the efficacy of concurrent radiotherapy and chemotherapy for laryngeal cancer. The data from 58 patients with newly diagnosed laryngeal cancer who had been treated at our hospital from August 2016 to March 2018 were collected. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.018DOI Listing

The incidence of thyroid gland invasion in advanced laryngeal squamous cell carcinoma.

Braz J Otorhinolaryngol 2019 Dec 9. Epub 2019 Dec 9.

King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Department of Surgery - Section of Otolaryngology-Head & Neck Surgery, Jeddah, Saudi Arabia.

Introduction: Invasion of the thyroid gland is not a general feature of advanced laryngeal carcinoma. There is no need for performing thyroidectomy in all total laryngectomy cases.

Objectives: To evaluate the frequency of the thyroid gland invasion in patients with advanced laryngeal squamous cell carcinoma submitted to total laryngectomy and thyroidectomy and to determine whether clinical and pathological characteristics of laryngeal carcinoma can predict glandular involvement. Read More

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http://dx.doi.org/10.1016/j.bjorl.2019.11.003DOI Listing
December 2019

Distant Intramuscular Metastases of Head and Neck Squamous Cell Carcinoma.

Ann Plast Surg 2020 01;84(1S Suppl 1):S11-S16

From the Division of Plastic Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.

Objectives: Metastasis of head and neck squamous cell carcinoma (HNSCC) usually occurs regionally in the neck lymph nodes, but also more infrequently at distant organs (eg, the lungs, bone, and liver). Intramuscular metastasis (IMM) has rarely been described. Therefore, we aimed to identify this disease characteristic and to evaluate available medical management options. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002175DOI Listing
January 2020

HPV infection and clinical profiles in laryngeal diseases. A preliminary study.

Ann Ital Chir 2019 ;90:398-403

Purpose: The study analysed the presence of HPV in samples tissue from laryngeal chronic hyperplastic inflammation, with and without pre-neoplastic potential, and from squamous cell carcinoma of the larynx. The aim of this analysis was to evaluate the presence/absence of different types of HPV and their relationship to the clinical profile of the patients studied (habit of smoking and drinking).

Methods: Sixty cases were randomly selected from patients undergoing surgical treatment of the larynx for inflammatory/ neoplastic lesions and of neck nodes. Read More

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Photodynamic therapy enables tumor-specific ablation in preclinical models of thyroid cancer.

Endocr Relat Cancer 2020 Feb;27(2):41-53

Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada.

The incidence of differentiated thyroid cancer has increased significantly during the last several decades. Surgical resection is the primary treatment for thyroid cancer and is highly effective, resulting in 5-year survival rates greater than 98%. However, surgical resection can result in short- and long-term treatment-related morbidities. Read More

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http://dx.doi.org/10.1530/ERC-19-0258DOI Listing
February 2020

Nasopharyngeal Stenosis: A Rare Radiotherapy Complication.

Indian J Otolaryngol Head Neck Surg 2019 Oct 22;71(Suppl 1):29-31. Epub 2015 Dec 22.

Otorhinolaryngology Department, Specialities Hospital, Medical School of Rabat, Mohammed V University, Abderrahim Bouabid avenue-Souissi, 10000 Rabat, Morocco.

Introduction: Acquired nasopharyngeal stenosis after radiotherapy for NPC is rare. We report a case of bilateral choanal stenosis and nasopharygeal stenosis in patient treated with chemo radiotherapy for undifferentieted nasopharnygeal carcinoma.

Case Report: A 68 years old man treated for undifferentiated nasopharyngeal carcinoma with chemo-radiotherapy 10 years before. Read More

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http://dx.doi.org/10.1007/s12070-015-0954-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848737PMC
October 2019

Incorporation of Astragalus polysaccharides injection during concurrent chemoradiotherapy in advanced pharyngeal or laryngeal squamous cell carcinoma: preliminary experience of a phase II double-blind, randomized trial.

J Cancer Res Clin Oncol 2020 Jan 14;146(1):33-41. Epub 2019 Nov 14.

Division of Medical Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou; College of Medicine, Chang Gung University, No. 5, Fushin St., Gueishan District, Taoyuan, 333, Taiwan, ROC.

Purpose: Concurrent chemoradiotherapy (CCRT) is one of the standard treatments for patients with advanced head and neck squamous cell carcinoma (HNSCC). However, CCRT may lead to decreased quality of life (QoL) and treatment compliance. This study aimed to determine the effects of PG2 (Astragalus polysaccharides) injection on CCRT-associated adverse events (AEs) and patients' compliance with the CCRT course. Read More

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http://dx.doi.org/10.1007/s00432-019-03033-8DOI Listing
January 2020

Mapping of sentinel lymph node drainage using SPECT/CT to tailor elective nodal irradiation in head and neck cancer patients (SUSPECT-2): a single-center prospective trial.

BMC Cancer 2019 Nov 14;19(1):1110. Epub 2019 Nov 14.

Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.

Background: The majority of patients with head and neck squamous cell carcinoma (HNSCC) receive bilateral elective nodal irradiation (ENI), in order to reduce the risk of regional failure. Bilateral ENI, as compared to unilateral ENI, is associated with higher incidence of acute and late radiation-induced toxicity with subsequent deterioration of quality of life. Increasing evidence that the incidence of contralateral regional failure (cRF) in lateralized HNSCC is very low (< 10%) suggests that it can be justified to treat selected patients unilaterally. Read More

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http://dx.doi.org/10.1186/s12885-019-6331-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857144PMC
November 2019

Treatment of a stage III rima glottidis patient with the oncolytic virus Rigvir: A retrospective case report.

Medicine (Baltimore) 2019 Nov;98(45):e17883

Rigvir.

Rationale: Of all the parts of the larynx, the glottis has the highest frequency of cancer. With disease progression, the vocal cord movement is affected and for advanced stages its anatomical and functional preservation is rarely achievable, if at all.

Patient Concerns: Here we describe a 72-year-old patient who presented with hoarseness for a year and was only able to whisper. Read More

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http://dx.doi.org/10.1097/MD.0000000000017883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855627PMC
November 2019
5.723 Impact Factor

Comparative evaluation of the diagnostic value of biopsy and NBI endoscopy in patients with cancer of the hypopharynx and larynx.

Otolaryngol Pol 2019 Jun;73(5):12-17

Klinika Otolaryngologii, Onkologii Laryngologicznej, Audiologii i Foniatrii, II Katedry Otolaryngologii Uniwersytetu Medycznego w Łodzi.

Introduction: Novel endoscopic technique - Narrow Band Imaging (NBI) seems to be a promising method for an early detection of neoplastic lesions of the upper aerodigestive tract. Compared to white light endoscopy, NBI improves the visualisation of the mucosal and submucosal microvascular patterns of observed pathologies. The aim of the study was to evaluate the diagnostic value of biopsy and NBI in patients with cancer of the larynx and hypopharynx. Read More

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http://dx.doi.org/10.5604/01.3001.0013.2309DOI Listing

Evaluation of narrow band imaging in the assessment of laryngeal granuloma.

Sci Rep 2019 11 6;9(1):16125. Epub 2019 Nov 6.

Department of Otolaryngology, Head and Neck Surgery, Poznań University of Medical Sciences, Poznań, Poland.

Laryngeal granulomas belong to common complications following trans-oral laser microsurgery (TLM). The aim of this study was to evaluate NBI in the differentiation between granuloma-like lesions and local tumor recurrence. 154 consecutive patients after TLM due to early laryngeal cancer were enrolled. Read More

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http://dx.doi.org/10.1038/s41598-019-50699-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834561PMC
November 2019

[Management of cerebral radionecrosis: experience in the Department of Neurology at the Mohammed V Military Teaching Hospital].

Pan Afr Med J 2019 11;33:188. Epub 2019 Jul 11.

Radiothérapie-oncologie, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.

Brain radionecrosis is a rare but life-threatening complication of external-beam radiotherapy for ENT cancers, in particular of the nasopharynx, and for brain tumors. Very few studies were conducted on this complication in the African population as well as in the Maghreb population. Therefore our study aims to describe the demographic, clinical, paraclinical, therapeutic and evolutionary features of cerebral radionecrosis in the Department of Neurology at the Mohammed V Military Teaching Hospital in Rabat over a period of 18 years (2000-2017). Read More

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http://dx.doi.org/10.11604/pamj.2019.33.188.19325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814324PMC
November 2019

Unusual case of papillary thyroid carcinoma mimicking paraganglioma in a 16-year-old girl.

Authors:
Saima Ahmad

Int J Surg Case Rep 2019 23;65:61-64. Epub 2019 Oct 23.

Pakistan Institute of Neurosciences, Neurointerventional Department, Lahore General Hospital, Ferozpur Road, Lahore, Pakistan. Electronic address:

Background: Papillary thyroid carcinoma is a common neoplasm arising from follicular cells of the thyroid. Differentiating the neck mass between thyroid paraganglioma and papillary thyroid carcinoma is often difficult.

Case Report: We report a 16-year-old girl with painless neck mass. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839010PMC
October 2019

Dose-volume histogram prediction in volumetric modulated arc therapy for nasopharyngeal carcinomas based on uniform-intensity radiation with equal angle intervals.

Phys Med Biol 2019 12 5;64(23):23NT03. Epub 2019 Dec 5.

School of Physics, Sun Yat-sen University, 135 Xin Gang Road West, Guangzhou, 510275, People's Republic of China.

In this study, we developed a gated recurrent unit (GRU)-based recurrent neural network (RNN) for dose-volume histogram (DVH) prediction in volumetric modulated arc therapy (VMAT) planning for nasopharyngeal carcinomas (NPCs) based on uniform-intensity radiation with equal angle intervals and investigated the feasibility and usefulness of this method for treatment optimization. One hundred twenty-four NPC patients were selected from a database containing clinical VMAT plans from 2015 to 2018; of these, the data from 100 patients were used to train the GRU-RNN, and the data of the other 24 patients were used for testing. For the prescribed doses to D (the absorbed dose for 95% of the planning target volume) of all the plans in 30 or 31 fractions, 70 Gy were delivered to PTV70 (the gross tumour volume with circumferential margin), 60 Gy were delivered to PTV60, 54 Gy were delivered to PTV54 and 66 Gy were delivered to PTV66 (lymph node gross tumour volume with circumferential margin). Read More

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http://dx.doi.org/10.1088/1361-6560/ab5433DOI Listing
December 2019
1 Read

Radiomic Nomogram Improves Preoperative T Category Accuracy in Locally Advanced Laryngeal Carcinoma.

Front Oncol 2019 15;9:1064. Epub 2019 Oct 15.

Department of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou, China.

Surgical decision-making on advanced laryngeal carcinoma is heavily depended on the identification of preoperative T category (T3 vs. T4), which is challenging for surgeons. A T category prediction radiomics (TCPR) model would be helpful for subsequent surgery. Read More

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http://dx.doi.org/10.3389/fonc.2019.01064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803547PMC
October 2019

Parotid secretory carcinoma with high-grade transformation.

Auris Nasus Larynx 2019 Oct 31. Epub 2019 Oct 31.

Department of Otolaryngology-Head and Neck Surgery, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

Here we present a patient with a parotid secretory carcinoma (SC) with high-grade transformation. A 65-year-old female was referred to our hospital due to a gradually growing right parotid tumor discovered initially about 4 years earlier. MRI imaging detected a right parotid tumor 50 mm in the longer axis. Read More

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http://dx.doi.org/10.1016/j.anl.2019.10.003DOI Listing
October 2019
1 Read

Asymptomatic Metastasis to Thyroid Cartilage Detected by 18F-Choline and 64Cu-PSMA PET/CT as a Single Site of Disease Relapse in a Patient With Castration-Resistant Prostate Carcinoma.

Clin Nucl Med 2020 Mar;45(3):214-216

From the Nuclear Medicine Unit.

Metastatic involvement of the larynx is rare due to the absence of vessels within the cartilaginous tissue. The probability of metastatic spread increases with aging as a result of larynx ossification. The secondary involvement of larynx is more frequently associated with melanoma and renal cell carcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002786DOI Listing

[Laryngeal Surgery - Malignant Lesions].

Laryngorhinootologie 2019 Oct 14;98(10):725-741. Epub 2019 Oct 14.

This article is intended to give an overview of the surgery for laryngeal malignancies and the current state of transoral endoscopic laryngeal surgery. The current therapy concepts in transoral endoscopic laryngeal surgery are presented in combination with the various possibilities of reconstruction. The adequate oncological treatment under functional aspects described plays the decisive role here: treatment goals beyond the cure of the tumor disease are the functional maintenance of the larynx with simultaneous preservation of the voice. Read More

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http://dx.doi.org/10.1055/a-0896-9444DOI Listing
October 2019

Papillary thyroid carcinoma with tracheal invasion: A case report.

Medicine (Baltimore) 2019 Sep;98(38):e17033

Rationale: Compared with most malignant tumors, papillary thyroid carcinoma (PTC) is usually associated with favorable survival and low recurrence rate. The prognostic factors of PTC include age, sex, tumor size, enlarged lymph nodes, and extrathyroidal extension. Among the extrathyroidal extension, upper aerodigestive tract (ADT) invasion by PTC is a marker of more aggressive tumor behavior, defining a subpopulation of patients at a greater risk of recurrence and death. Read More

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http://dx.doi.org/10.1097/MD.0000000000017033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756740PMC
September 2019
2 Reads

Hyperspectral Imaging of Head and Neck Squamous Cell Carcinoma for Cancer Margin Detection in Surgical Specimens from 102 Patients Using Deep Learning.

Cancers (Basel) 2019 Sep 14;11(9). Epub 2019 Sep 14.

Department of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.

Surgical resection of head and neck (H and N) squamous cell carcinoma (SCC) may yield inadequate surgical cancer margins in 10 to 20% of cases. This study investigates the performance of label-free, reflectance-based hyperspectral imaging (HSI) and autofluorescence imaging for SCC detection at the cancer margin in excised tissue specimens from 102 patients and uses fluorescent dyes for comparison. Fresh surgical specimens ( = 293) were collected during H and N SCC resections ( = 102). Read More

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http://dx.doi.org/10.3390/cancers11091367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769839PMC
September 2019
2 Reads

Pretreatment Serum Levels of Soluble Cytokeratin Fragments (Cyfra 21-1, TPS, MonoTotal) in Relation to Clinical and Pathobiological Aspects of Head and Neck Squamous Cell Carcinomas.

Anticancer Res 2019 Sep;39(9):5171-5177

Department of Biology, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.

Background/aim: The aim of this study was to analyze the pretreatment cytokeratin serum levels in head and neck squamous cell carcinoma (HNSCC) by three assays in relation to selected clinicopathological characteristics in an effort to find diagnostic/prognostic biomarkers for HNSCC and determine the best assay.

Patients And Methods: In total, 46 patients with HNSCC with different subsite (oropharyngeal-21 cases, hypopharyngeal-4 and laryngeal-21) were included in this prospective study. MonoTotal, Cyfra 21-1, and TPS radioimmunoassay kits were used to analyze cytokeratin fragments serum levels. Read More

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http://dx.doi.org/10.21873/anticanres.13713DOI Listing
September 2019
3 Reads

Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma.

Cancers (Basel) 2019 Sep 6;11(9). Epub 2019 Sep 6.

Department of Otorhinolaryngology, Head & Neck Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy for T2N0 glottic carcinoma.

Methods: Patients with T2N0 glottic carcinoma treated with radiotherapy were included in this retrospective study. Read More

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http://dx.doi.org/10.3390/cancers11091319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770714PMC
September 2019
2 Reads

Evaluation of quantitative imaging parameters in head and neck squamous cell carcinoma.

Q J Nucl Med Mol Imaging 2019 Sep 5. Epub 2019 Sep 5.

Department of Radiation Oncology, Advanced Centre for Treatment Research & Education in Cancer (ACTREC), Tata Memorial Hospital (TMH), Tata Memorial Centre, Mumbai, India.

Background: Functional imaging such as 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT), 18F-fluoro-misonidazole (F-MISO)-PET/CT, and diffusion-weighted magnetic resonance imaging (DW-MRI) can assess complex biological phenomena in tumors reflecting underlying disease biology. The aim of this prospective observational study was to correlate quantitative imaging parameters derived from pre-treatment biological imaging such as FDG-PET/CT, F-MISO-PET/CT, and DW-MRI with each other andì with clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC) treated with definitive radio(chemo)therapy.

Methods: Twenty patients with pharyngo-laryngeal cancers underwent pre-treatment biological imaging. Read More

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https://www.minervamedica.it/index2.php?show=R39Y9999N00A190
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http://dx.doi.org/10.23736/S1824-4785.19.03179-0DOI Listing
September 2019
9 Reads
2.033 Impact Factor

Simultaneous presentation of parathyroid carcinoma, papillary thyroid cancer and ACTH-independent hypercortisolism due to benign cortical adenoma.

BMJ Case Rep 2019 Sep 5;12(9). Epub 2019 Sep 5.

Oncology and Metabolism, University of Sheffield, Sheffield, UK.

A 46-year-old woman presented with hypertension and renal disease. Investigations showed severe hypercalcaemia due to primary hyperparathyroidism. Imaging demonstrated renal calculi and an incidental left adrenal lesion. Read More

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http://dx.doi.org/10.1136/bcr-2019-230438DOI Listing
September 2019
6 Reads

Vocal Cord Metastasis.

N Engl J Med 2019 Sep;381(10):e18

Hospital Universitario del Henares, Coslada, Spain

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http://dx.doi.org/10.1056/NEJMicm1815495DOI Listing
September 2019
6 Reads

Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin America.

Arch Endocrinol Metab 2019 2;63(5):462-469. Epub 2019 Sep 2.

Division of Endocrinology, Hospital de Clinicas, University of Buenos Aires Buenos Aires, Argentina.

Objectives: To determine the percentage of patients with papillary thyroid carcinoma (PTC) who accepted active surveillance as an alternative to surgery in our clinical practice and to describe the clinical characteristics and outcomes of patients with Bethesda category V and VI thyroid nodules who chose active surveillance.

Subjects And Methods: We included 136 PTC patients from the Hospital de Clínicas, University of Buenos Aires without (i) US extrathyroidal extension, (ii) tumors adjacent to the recurrent laryngeal nerve or trachea, and/or (iii) US regional lymph-node metastasis or clinical distant metastasis. PTC progression was defined as the presence of i) a tumor larger than ≥ 3 mm, ii) novel appearance of lymph-node metastasis, and iii) serum thyroglobulin doubling time in less than one year. Read More

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http://dx.doi.org/10.20945/2359-3997000000168DOI Listing
October 2019
3 Reads

Thyroid nodules ≤ 1 cm and papillary thyroid microcarcinomas: Brazilian experts opinion.

Arch Endocrinol Metab 2019 2;63(5):456-461. Epub 2019 Sep 2.

Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.

The indolent evolution of low-risk papillary thyroid microcarcinoma (mPTC) in adult patients and the consequences of thyroidectomy require a revision of the management traditionally recommended. Aiming to spare patients unnecessary procedures and therapies and to optimize the health system in Brazil, we suggest some measures. Fine-needle aspiration of nodules ≤ 1 cm without extrathyroidal extension on ultrasonography should be performed only in nodules classified as "very suspicious" (i. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.20945/2359-3997000000166DOI Listing
October 2019
5 Reads

Massive hemoptysis: an unusual presentation of papillary thyroid carcinoma due to tracheal invasion.

BMJ Case Rep 2019 Aug 21;12(8). Epub 2019 Aug 21.

Division of Pulmonary, Critical Care & Sleep Medicine, Baylor Scott and White Central Texas, Temple, Texas, USA.

A 67-year-man presented to the emergency department with massive hemoptysis, coughing up about 250 mL frank blood in 2-3 hours. Physical examination was significant for tachycardia, tachypnea and blood around the mouth. A CT of the chest did not reveal any aetiology of hemoptysis. Read More

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http://dx.doi.org/10.1136/bcr-2019-229330DOI Listing
August 2019
3 Reads

Think Twice Before Extracting a Harmless Foreign Body From the Upper Esophagus.

Gastroenterology 2020 02 5;158(3):e3-e5. Epub 2019 Aug 5.

The Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, Zerifin, affiliated with the Sackler School of Medicine, Tel Aviv University, Israel. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.07.054DOI Listing
February 2020

P53/MDM2 Co-Expression in Laryngeal Squamous Cell Carcinoma Based on Digital Image Analysis.

Anticancer Res 2019 Aug;39(8):4137-4142

First Department of Otorhinolaryngology, Head and Neck Surgery, Hippocration Hospital, University of Athens, Athens, Greece.

Background: P53 is a key regulator of genomic stability and function, acting as a tumor suppressor protein. Our aim was to correlate P53 expression with murine double minute 2 (MDM2), a proto-oncogene that interacts with P53 and forms an auto-regulatory pathway, in laryngeal squamous cell carcinoma (LSCC).

Materials And Methods: A total of 50 LSCC cases were included in the study. Read More

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http://dx.doi.org/10.21873/anticanres.13572DOI Listing
August 2019
3 Reads

Primary triple head and neck tumors: Laryngeal squamous cell carcinomas, Kaposi's sarcoma, and non-Hodgkin's lymphoma.

Indian J Pathol Microbiol 2019 Jul-Sep;62(3):454-456

Department of Otorhinolaryngology, Bagcilar Training and Research Hospital, Istanbul, Turkey.

Simultaneously triple head and neck malignancies are extremely rare. We report a case who had epithelial and mesenchymal malignant tumor with lymphoid malignancy in head and neck area. A patient who is 74 year old male patient presented to the otorhinolaryngology department with severe breathing difficulty due to laryngeal mass. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_555_18DOI Listing
December 2019
3 Reads

Induction chemotherapy in head and neck cancers: Results and controversies.

Oral Oncol 2019 08 25;95:164-169. Epub 2019 Jun 25.

Centre de Lutte Contre le Cancer Léon Bérard, Lyon-I University, Lyon, France. Electronic address:

Standard treatment for locally advanced head and neck squamous cell carcinoma (LAHNSCC) consists mainly of concurrent chemoradiation (CCR) but induction chemotherapy (IC) by docetaxel-cisplatin-fluorouracil (TPF), followed by CCR, is a strong option. Comparative trials suggest that IC and CCR are equivalent, and some trials suggest superiority of IC, whereas none shows inferiority. IC might have less interest in oropharyngeal cancer (more often linked to HPV infection). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.06.015DOI Listing
August 2019
1 Read

CO Transoral Laser Microsurgery in Benign, Premalignant and Malignant (Tis, T1, T2) Lesion of the Glottis. A Literature Review.

Medicines (Basel) 2019 Jul 22;6(3). Epub 2019 Jul 22.

Otorhinolaryngology-Head & Neck surgery Department, Hospital Universitario Donostia, 20014 San Sebastian-Donostia, Spain.

Carbon Dioxide transoral laser microsurgery represents a reliable option for the treatment of early glottic carcinoma (Tis-T2), with good functional and oncological outcomes, nowadays representing one of the main options in larynx preservation protocols. The development and improvement of laser devices means surgeons are able to use more precise instruments compared with classic cold dissection in laser-assisted phonosurgery. Secondary effects on voice, swallowing, or quality of life as well as complications have been well documented. Read More

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http://dx.doi.org/10.3390/medicines6030077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789531PMC

Updated WHO nomenclature of head and neck lesions and associated imaging findings.

Insights Imaging 2019 Jul 16;10(1):72. Epub 2019 Jul 16.

Department of Radiology, Section of Neuroradiology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.

This article reviews the imaging features of head and neck lesions with updated 2017 World Health Organization (WHO) nomenclature. The major WHO changes include refined terminology of existing entities, descriptions of new tumor types, elimination of defunct categories, and updated biological characterization of various tumor types. In particular, the updates pertaining to the following conditions will be reviewed: tumors of the oral cavity and oropharynx, including HPV-positive or HPV-negative squamous cell carcinoma, small cell carcinoma; tumors of the hypopharynx, larynx, trachea, and parapharyngeal space, including nomenclature revisions for laryngeal neuroendocrine tumors; tumors of the nasal cavity and paranasal sinuses including newly added entities such as NUT carcinoma and biphenotypic sinonasal sarcoma; odontogenic and maxillofacial bone tumors, including the reversal of terminology for certain cystic lesions; tumors of the salivary glands, including updated terminology related to high-grade transformation and polymorphous adenocarcinomas tumors; temporal bone lesions including modifications of the nomenclature and classification criteria; tumor-like lesions of the neck and lymph nodes, with a discussion encompassing developmental cysts, metastases of unknown primary, and heterotopia-associated neoplasia; and mucosal melanoma. Read More

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http://dx.doi.org/10.1186/s13244-019-0760-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635538PMC
July 2019
9 Reads

Evaluation of the antileukemic effects of neurokinin-1 receptor antagonists, aprepitant, and L-733,060, in chronic and acute myeloid leukemic cells.

Anticancer Drugs 2019 08;30(7):e0769

Pharmaceutical Microbiology, Faculty of Pharmacy.

Neurokinin-1 receptor (NK1R) antagonists are known for their anxiolytic, antiemetic, anticancer, and anti-inflammatory effects. Aprepitant is used in vomiting and nausea, which are the most common side-effects of patients undergoing chemotherapy for cancer. L-733,060 has been shown to have anxiolytic and antidepressant effects in animal studies and anticancer effect in in-vitro studies. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000769DOI Listing
August 2019
5 Reads

Evaluation of the Expression of Matrix Metalloproteinase-1 of Laryngeal Squamous Cell Carcinoma by Ultrasound Molecular Imaging.

Front Pharmacol 2019 19;10:655. Epub 2019 Jun 19.

Department of Ultrasound, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

The aims of this study were to evaluate the expression of matrix metalloproteinase-1 (MMP-1) on laryngeal squamous cell carcinoma (LSCC) and improve the early diagnosis rate ultrasound molecular imaging (USMI). The microsized MMP-1-targeted microbubbles (MB) and the control MBs (MB) based on perfluorocarbon-filled lipid-shelled MBs were constructed and characterized. The binding experiment was performed with human epidermoid laryngeal cancer cells (HEp-2) and tested the binding efficiency of MB and MB. Read More

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http://dx.doi.org/10.3389/fphar.2019.00655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593083PMC
June 2019
4 Reads