1,981 results match your criteria Laryngeal Carcinoma Imaging

18F-Fluorodeoxyglucose Positron Emission Tomography of Head and Neck Cancer: Location and HPV Specific Parameters for Potential Treatment Individualization.

Front Oncol 2022 8;12:870319. Epub 2022 Jun 8.

German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ) Heidelberg, Germany, Germany.

Purpose: 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is utilized for staging and treatment planning of head and neck squamous cell carcinomas (HNSCC). Some older publications on the prognostic relevance showed inconclusive results, most probably due to small study sizes. This study evaluates the prognostic and potentially predictive value of FDG-PET in a large multi-center analysis. Read More

View Article and Full-Text PDF

Videomics of the Upper Aero-Digestive Tract Cancer: Deep Learning Applied to White Light and Narrow Band Imaging for Automatic Segmentation of Endoscopic Images.

Front Oncol 2022 1;12:900451. Epub 2022 Jun 1.

Unit of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Introduction: Narrow Band Imaging (NBI) is an endoscopic visualization technique useful for upper aero-digestive tract (UADT) cancer detection and margins evaluation. However, NBI analysis is strongly operator-dependent and requires high expertise, thus limiting its wider implementation. Recently, artificial intelligence (AI) has demonstrated potential for applications in UADT videoendoscopy. Read More

View Article and Full-Text PDF

Case Report: Extramedullary Acute Promyelocytic Leukemia: An Unusual Case and Mini-Review of the Literature.

Front Oncol 2022 25;12:886436. Epub 2022 May 25.

Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.

Background: Acute promyelocytic leukemia (APL) constitutes a serious hematological emergency necessitating rapid diagnosis and therapy to prevent lethal bleedings resulting from APL-induced thrombocytopenia and coagulopathy. Atypical manifestations of APL, such as extramedullary disease at first presentation, pose diagnostic challenges and delay the onset of appropriate therapy. Nevertheless, extramedullary manifestations of APL are mostly accompanied by blood count alterations pointing to an underlying hematological disease. Read More

View Article and Full-Text PDF

Machine-learning-assisted spontaneous Raman spectroscopy classification and feature extraction for the diagnosis of human laryngeal cancer.

Comput Biol Med 2022 Jul 18;146:105617. Epub 2022 May 18.

Division of Electrical and Computer Engineering, College of Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA. Electronic address:

The early detection of laryngeal cancer significantly increases the survival rates, permits more conservative larynx sparing treatments, and reduces healthcare costs. A non-invasive optical form of biopsy for laryngeal carcinoma can increase the early detection rate, allow for more accurate monitoring of its recurrence, and improve intraoperative margin control. In this study, we evaluated a Raman spectroscopy system for the rapid intraoperative detection of human laryngeal carcinoma. Read More

View Article and Full-Text PDF

Diagnostic impact of F-FDG PET/CT imaging on the detection of immune-related adverse events in patients treated with immunotherapy.

Clin Transl Oncol 2022 May 20. Epub 2022 May 20.

Department of Nuclear Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Introduction: Immunotherapy is an effective treatment method for cancer cells with humoral and cellular immune mechanisms of action but triggers an inflammatory response and disrupts standard protective immune tolerance. Early detection of immune-related adverse events (irAEs) on PET/CT is crucial for patient management and subsequent therapy decisions. In this study, we aimed to evaluate the impact of F-FDG PET/CT on detecting of irAEs in patients receiving immunotherapy. Read More

View Article and Full-Text PDF

Predictors of Thyroid Gland Invasion in Total Laryngectomy for Advanced Laryngeal Squamous Cell Carcinoma.

Ear Nose Throat J 2022 May 9:1455613221098300. Epub 2022 May 9.

Department of Otolaryngology-Head and Neck Surgery, 89346Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Thyroidectomy for advanced laryngeal squamous cell carcinoma (LSCC) is controversial. This study aimed to identify predictors of thyroid gland invasion in patients with LSCC and management of the thyroid gland during total laryngectomy. Clinical data and pathological characteristics of 113 patients, who underwent laryngectomy with thyroidectomy for advanced LSCC in Guangdong Provincial People's Hospital between 2009 and 2019, were retrospectively analyzed. Read More

View Article and Full-Text PDF

Vocal fold fibroblasts promote angiogenesis in vocal fold leukoplakia by secreting pro-angiogenic factors.

Auris Nasus Larynx 2022 May 2. Epub 2022 May 2.

ENT Institute and Department of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China. Electronic address:

Objective: Cancer-associated fibroblasts (CAFs) have been reported to play an essential role in tumor angiogenesis and progression. In this study, we aimed to investigate the impact of vocal fold leukoplakia-associated fibroblasts (VFLFs) on the angiogenesis process in vocal fold leukoplakia (VFL) and their potential secretions of proangiogenic factors.

Methods: A total of 160 lesions (86 laryngeal carcinoma, 67 vocal fold leukoplakia, 7 vocal fold polyp) were detected under narrow band imaging (NBI) mode to evaluate the relationship between pathology and intraepithelial papillary capillary loop (IPCL) grades. Read More

View Article and Full-Text PDF

Semi-prone thoracoscopic esophagectomy for esophageal carcinoma with aberrant right subclavian artery and non-recurrent inferior laryngeal nerve.

J Cardiothorac Surg 2022 Apr 23;17(1):81. Epub 2022 Apr 23.

Department of General Surgery, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, Yokohama City, Kanagawa, 247-8512, Japan.

Background: Aberrant right subclavian artery (ARSA) accompanied by non-recurrent inferior laryngeal nerve (NRILN) is a rare anomaly. In cases of thoracic esophageal carcinoma associated with ARSA and NRILN, surgeons must take extra care not to injury these vessels and nerves. We believe semi-prone thoracoscopic esophagectomy to be a surgical approach that can safely deal with such an anomaly. Read More

View Article and Full-Text PDF

Preoperative Clinical Characteristics Predict Recurrent Laryngeal Nerve Lymph Node Metastasis and Overall Survival in Esophageal Squamous Cell Carcinoma: A Retrospective Study With External Validation.

Front Oncol 2022 31;12:859952. Epub 2022 Mar 31.

Department of Cardiothoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Background: Recurrent laryngeal nerve (RLN) lymph node metastasis (LNM) is not rare in patients with esophageal squamous cell carcinoma (ESCC). We aimed to develop and externally validate a preoperative nomogram using clinical characteristics to predict RLN LNM in patients with ESCC and evaluate its prognostic value.

Methods: A total of 430 patients with ESCC who underwent esophagectomy with lymphadenectomy of RLN LNs at two centers between May 2015 and June 2019 were reviewed and divided into training (center 1, n = 283) and external validation cohorts (center 2, n = 147). Read More

View Article and Full-Text PDF

An unusual foreign body in the laryngeal trachea following supracricoid partial laryngectomy.

Br J Hosp Med (Lond) 2022 03 24;83(3). Epub 2022 Mar 24.

Department of Otorhinolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

View Article and Full-Text PDF

The characteristics of missed pharyngeal and laryngeal cancers at gastrointestinal endoscopy.

Jpn J Clin Oncol 2022 May;52(6):575-582

Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.

Objectives: Understanding the miss rate and characteristics of missed pharyngeal and laryngeal cancers during upper gastrointestinal endoscopy may aid in reducing the endoscopic miss rate of this cancer type. However, little is known regarding the miss rate and characteristics of such cancers. Therefore, the aim of this study was to investigate the upper gastrointestinal endoscopic miss rate of oro-hypopharyngeal and laryngeal cancers, the characteristics of the missed cancers, and risk factors associated with the missed cancers. Read More

View Article and Full-Text PDF

Ultrasonography for masses of the pharynx and larynx and assessment of laryngeal squamous cell carcinoma.

Auris Nasus Larynx 2022 Oct 27;49(5):868-874. Epub 2022 Mar 27.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.

Objective: To evaluate the ultrasonography (US) characteristics of pharyngeal/laryngeal masses and the role of US in the assessment of laryngeal squamous cell carcinoma (LSCC).

Methods: This study enrolled patients who underwent US for evaluation of pharyngeal/laryngeal masses between 2018 and 2021. Characteristics of pharyngeal/laryngeal masses and subsite invasion in cases of LSCC were evaluated using US. Read More

View Article and Full-Text PDF
October 2022

Masseter muscle defined sarcopenia and survival in head and neck cancer patients.

Br J Oral Maxillofac Surg 2022 May 5;60(4):454-458. Epub 2021 Aug 5.

Department of Clinical Oncology, Shrewsbury and Telford Hospital NHS Trust, Telford, UK.

Sarcopenia is increasingly recognised as a poor prognostic factor in older patients undergoing cancer treatment. Recently, masseter muscle cross sectional area (MMCSA) has been shown to accurately identify sarcopenic patients. We aimed to apply this novel technique to a head and neck cohort to identify any potential relationship with survival. Read More

View Article and Full-Text PDF

Anaplastic thyroid carcinoma in a brush-tailed rock-wallaby (Petrogale penicillata).

Aust Vet J 2022 Jun 8;100(6):271-276. Epub 2022 Mar 8.

Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation (CSIRO), East Geelong, Victoria, Australia.

Background: Neoplasia is considered to be rare in macropods. Anaplastic thyroid carcinoma (ATC) also known as undifferentiated or giant cell carcinoma, is a rare but aggressive and lethal solid tumour reported to affect humans, dogs, cats, racoons and birds. It is derived from poorly differentiated follicular cells and lacks the characteristic architectural pattern of arrangement of tumour cells. Read More

View Article and Full-Text PDF

Small Cell Neuroendocrine Carcinoma of the Paranasal Sinuses with Unexpected Location and Clinical Presentation and Occupational Exposure: A Case Report.

Am J Case Rep 2022 Mar 2;23:e934980. Epub 2022 Mar 2.

Department of Medical Oncology, Cancer Center GF Leclerc, Dijon, France.

BACKGROUND Small cell carcinoma (SCC) is usually aggressive and associated with a poor prognosis. This type of cancer is rarely found in extra-pulmonary or digestive-tract locations. This report describes an unusual presentation in terms of clinical symptoms and primary location (even among head and neck presentations), and unexpected occupational exposure. Read More

View Article and Full-Text PDF

Validity of tissue homogeneity in confocal laser endomicroscopy on the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma.

Eur Arch Otorhinolaryngol 2022 Feb 28. Epub 2022 Feb 28.

Department of Otorhinolaryngology, Plastic Head and Neck Surgery, Rheinische Westfälische Technische Hochschule Aachen, University Hospital, Aachen, Germany.

Purpose: Confocal laser endomicroscopy (CLE) allows imaging of the laryngeal mucosa in a thousand-fold magnification. This study analyzes differences in tissue homogeneity between healthy mucosa and squamous cell carcinoma (SCC) via CLE.

Materials And Methods: We included five SCC patients with planned total laryngectomy in this study between October 2020 and February 2021. Read More

View Article and Full-Text PDF
February 2022

Re-administration of nivolumab after immune checkpoint inhibitor-induced cholangitis: the first reported case.

Clin J Gastroenterol 2022 Apr 24;15(2):467-474. Epub 2022 Feb 24.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Immune checkpoint inhibitors (ICIs) cause various immune-related adverse events (irAEs). We encountered a patient in whom nivolumab was re-administered effectively and safely treat laryngeal cancer after nivolumab-induced cholangitis. A 60-year-old man with metastatic laryngeal squamous cell carcinoma received 3rd-line treatment with nivolumab. Read More

View Article and Full-Text PDF

Response-Adapted Treatment Following Radiotherapy in Patients With Resectable Locally Advanced Hypopharyngeal Carcinoma.

JAMA Netw Open 2022 02 1;5(2):e220165. Epub 2022 Feb 1.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Importance: Laryngeal preservation strategies for resectable locally advanced hypopharyngeal carcinoma (LAHPC) have been explored. However, the optimal strategy remains unclear.

Objective: To evaluate a response-adapted strategy based on an early response to radiotherapy (RT) in patients with resectable LAHPC. Read More

View Article and Full-Text PDF
February 2022

Magnetic resonance guided elective neck irradiation targeting individual lymph nodes: A new concept.

Phys Imaging Radiat Oncol 2021 Oct 10;20:76-81. Epub 2021 Nov 10.

Department of Radiotherapy, University Medical Centre Utrecht, the Netherlands.

Background And Purpose: Conventional elective neck irradiation (ENI) in head and neck cancer consists of radiotherapy (RT) to the regional lymph node (LN) levels contoured on computed tomography. Hybrid Magnetic Resonance (MR) - RT modalities, such as combined magnetic resonance imaging - linear accelerators (MRLs), might enable new ENI strategies in which individual non-suspect lymph nodes (i-LNs) are targeted. In this treatment planning study, new MR-based strategies targeting i-LNs (i-ENI) were compared to conventional treatment. Read More

View Article and Full-Text PDF
October 2021

Long-term management of recurrent papillary thyroid carcinoma treated with lenvatinib for over 5 years: a case report.

Surg Case Rep 2022 Jan 27;8(1):21. Epub 2022 Jan 27.

Kachi Memorial Hospital, 456 Fujimi, Minami-ohshimizu-cho, Toyohashi, Aichi, 441-8555, Japan.

Background: Few reports exist of the long-term management of recurrent and progressive papillary thyroid carcinoma (PTC) with a tyrosine kinase inhibitor for over 5 years.

Case Presentation: A 57-year-old woman was referred to a psychiatric hospital for the treatment of schizophrenia. The patient had been diagnosed with a PTC at the age of 40 and subsequently underwent a left thyroid lobectomy. Read More

View Article and Full-Text PDF
January 2022

Comparison of an in-house hybrid DIR method to NiftyReg on CBCT and CT images for head and neck cancer.

J Appl Clin Med Phys 2022 Mar 27;23(3):e13540. Epub 2022 Jan 27.

Department of Radiation Oncology, Jiangxi Cancer Hospital of Nanchang University, Nanchang, P. R. China.

An in-house hybrid deformable image registration (DIR) method, which combines free-form deformation (FFD) and the viscous fluid registration method, is proposed. Its results on the planning computed tomography (CT) and the day 1 treatment cone-beam CT (CBCT) image from 68 head and neck cancer patients are compared with the results of NiftyReg, which uses B-spline FFD alone. Several similarity metrics, the target registration error (TRE) of annotated points, as well as the Dice similarity coefficient (DSC) and Hausdorff distance (HD) of the propagated organs at risk are employed to analyze their registration accuracy. Read More

View Article and Full-Text PDF

A deep convolutional neural network-based method for laryngeal squamous cell carcinoma diagnosis.

Ann Transl Med 2021 Dec;9(24):1797

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University; Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, China.

Background: Laryngeal squamous cell carcinoma (LSCC) is one of the most common tumors of the respiratory tract. Currently, the diagnosis of LSCC is mainly based on a laryngoscopy analysis and pathological findings. Deep-learning algorithms have been shown to provide accurate clinical diagnoses. Read More

View Article and Full-Text PDF
December 2021

BODIPY and 2,3-Dihydrophthalazine-1,4-Dione Conjugates As Heavy Atom-Free Chemiluminogenic Photosensitizers.

ACS Appl Bio Mater 2021 06 8;4(6):5090-5098. Epub 2021 Jun 8.

Department of Biotechnology & ASUBTAM M. Bilmez BioNanoTech Lab., Aksaray University, TR-68100 Aksaray, Turkey.

We disclose an interesting concept for developing heavy atom-free chemiluminogenic photosensitizers. To accomplish this, conjugates and , which are composed of boron-dipyrromethene (BODIPY) and 2,3-dihydrophthalazine-1,4-dione units, are investigated. and are compared in terms of their photophysical properties, chemiluminescence responses, and singlet oxygen production. Read More

View Article and Full-Text PDF

Mucoepidermoid Carcinomas of the Larynx.

Ann Otol Rhinol Laryngol 2022 Jan 6:34894211069459. Epub 2022 Jan 6.

Oregon Health and Science University School of Medicine, Portland, OR, USA.

Objectives: Discussions regarding the specific management and outcomes for laryngeal MEC are limited to very small, single-institution case series. To look further into the diagnosis and management of these uncommon non-squamous cell carcinomas of the larynx, we present 3 recent cases of laryngeal MEC treated at our institution.

Methods: Patients at a tertiary hospital treated for MEC between October 2019 and December 2020 were retrospectively identified. Read More

View Article and Full-Text PDF
January 2022

Automatic detection of head and neck squamous cell carcinoma on pathologic slides using polarized hyperspectral imaging and machine learning.

Proc SPIE Int Soc Opt Eng 2021 Feb 15;11603. Epub 2021 Feb 15.

The University of Texas at Dallas, Department of Bioengineering and Center for Imaging and Surgical Innovation, Richardson, TX.

The aim of this study is to incorporate polarized hyperspectral imaging (PHSI) with machine learning for automatic detection of head and neck squamous cell carcinoma (SCC) on hematoxylin and eosin (H&E) stained tissue slides. A polarized hyperspectral imaging microscope had been developed in our group. In this paper, we imaged 20 H&E stained tissue slides from 10 patients with SCC of the larynx by the PHSI microscope. Read More

View Article and Full-Text PDF
February 2021

TransOral UltraSonic surgery (TOUSS) for oral cavity, oropharyngeal and supraglottic malignancy: A prospective study of feasibility, safety, margins, functional and survival outcomes.

Oral Oncol 2022 01 11;124:105643. Epub 2021 Dec 11.

Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Introduction/background: With the advent of TransOral Robotic Surgery (TORS) the ease of transoral procedures has been dramatically improved. TORS is already established for its feasibility, functional and oncological outcomes for selected lesions of oral cavity, oropharynx and laryngopharynx. This study reports on preliminary results with TransOral UltraSonic Surgery (TOUSS) for oncologic resections of oral cavity, oropharyngeal and supraglottic malignancies. Read More

View Article and Full-Text PDF
January 2022

[Risk and prognostic analysis of cervical lymph node metastasis in cN+ laryngeal squamous cell carcinoma].

Hao Zhang Guohua Hu

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Dec;35(12):1115-1119;1123

Department of Otorhinolaryngology,First Affiliated Hospital of Chongqing Medical University,Chongqing,400016,China.

To analyze the clinical, pathological features and metastatic regularity of cervical lymph node metastasis in cN+ laryngeal squamous cell carcinoma, and to explore its diagnosis and management. Among 1030 patients with laryngeal squamous cell carcinoma who underwent surgery in the Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University from March 2011 to January 2021, 83 patients with cN+ were included in the retrospective analysis of clinical data and follow-up data. Among the 83 cases of cN+ laryngeal carcinoma, there were pN+65 cases and pN-18 cases. Read More

View Article and Full-Text PDF
December 2021

Pembrolizumab plus docetaxel for the treatment of recurrent/metastatic head and neck cancer: A prospective phase I/II study.

Oral Oncol 2022 01 26;124:105634. Epub 2021 Nov 26.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, Vienna A-1090, Austria.

Background: Taxane-based checkpoint inhibitor combination therapy might improve the outcome in recurrent/metastatic (R/M) head and neck cancer (HNSCC) patients. Thus, we investigated the efficacy and safety of docetaxel (DTX) plus pembrolizumab (P) in a prospective phase I/II trial.

Methods: Platinum-resistant R/M HNSCC patients received DTX 75 mg/m^ plus P 200 mg for up to six cycles followed by P maintenance therapy. Read More

View Article and Full-Text PDF
January 2022

Synchronous mucosal and intraosseous oral cavity carcinomas: a case of rare occult second primary malignancy.

Ann R Coll Surg Engl 2022 May 29;104(5):e150-e152. Epub 2021 Nov 29.

Lancashire Teaching Hospitals NHS Foundation Trust, UK.

Secondary primary malignancies within the head and neck region are well documented. Within this group, synchronous tumours with an index oral cancer are usually found in the oropharyngeal or laryngeal sites. We present a rare case of an index squamous cell carcinoma in the tongue with a synchronous primary intraosseous squamous cell carcinoma. Read More

View Article and Full-Text PDF

Efficacy of endoscopic ultrasonography in evaluating tumor thickness in patients with superficial pharyngeal carcinoma: A pilot study.

Auris Nasus Larynx 2022 Jun 25;49(3):495-503. Epub 2021 Nov 25.

Digestive and Lifestyle Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Objectives: A histopathological tumor thickness of ≥1000 μm has been reported as one of many risk factors for recurrent lymph node metastasis in superficial pharyngeal cancer (SPC). However, methods for assessing this risk factor preoperatively have not yet been established. Hence, the current study aimed to evaluate the efficacy of endoscopic ultrasonography (EUS) in measuring tumor thickness preoperatively in patients with SPC. Read More

View Article and Full-Text PDF