1,660 results match your criteria Laryngeal Carcinoma Imaging


Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation.

Laryngoscope 2019 Feb 12. Epub 2019 Feb 12.

Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.

Objectives: We aim to report oncologic outcomes after conventional radiotherapy (ConRT) using opposed lateral beams and intensity-modulated radiation therapy (IMRT) for tumor (T)1 nodal (N)0 T1 N0 glottic squamous cell carcinoma.

Study Design: Retrospective case-control study.

Methods: We retrospectively reviewed demographic, disease, and treatment characteristics for patients treated at our institution during 2000 to 2013. Read More

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http://dx.doi.org/10.1002/lary.27873DOI Listing
February 2019

Probe-based confocal laser endomicroscopy in detecting malignant lesions of vocal folds.

Acta Otorhinolaryngol Ital 2019 Jan 31. Epub 2019 Jan 31.

Department of Otorhinolaryngology, Head and Neck Surgery, Universität Regensburg, University Hospital, Regensburg, Germany.

Probe-based confocal laser endomicroscopy (CLE) is an innovative technique for real-time, non-invasive analysis of the surface epithelium. While being successfully used for diagnosis by experts, this method has not yet been established in clinical routine, partly due to the lack of standards and criteria for classifying various lesions. Our aim was to determine the diagnostic value and inter-rater reliability of CLE in detecting malignant lesions of the vocal cords. Read More

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http://dx.doi.org/10.14639/0392-100X-2121DOI Listing
January 2019

Collision carcinoma of squamous cell carcinoma and small cell neuroendocrine carcinoma of the larynx: A case report and review of the literature.

World J Clin Cases 2019 Jan;7(2):242-252

Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Background: Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma (SCC) and neuroendocrine carcinoma (NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and treatment.

Case Summary: A 61-year-old man presented with a 1-year history of hoarseness. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i2.242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354099PMC
January 2019

Role of narrow band imaging in the diagnosis of laryngeal lesions: Pilot study from India.

Indian J Cancer 2018 Jul-Sep;55(3):242-247

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Narrow band imaging (NBI) is a new imaging technique developed to improve the diagnostic accuracy of head and neck cancers by depiction of tumor-specific neo-angiogenesis. The purpose of this study was to assess the value of NBI in the diagnosis of laryngeal lesions.

Aim: To assess the sensitivity and specificity of combined white light endoscopy (WLE) and NBI compared with WLE alone in the diagnosis of laryngeal lesions. Read More

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http://dx.doi.org/10.4103/ijc.IJC_590_17DOI Listing
January 2019
1 Read

Prediction of Posterior Paraglottic Space and Cricoarytenoid Unit Involvement in Endoscopically T3 Glottic Cancer with Arytenoid Fixation by Magnetic Resonance with Surface Coils.

Cancers (Basel) 2019 Jan 10;11(1). Epub 2019 Jan 10.

Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano, University of Milan, 20133 Milan, Italy.

Discrimination of the etiology of arytenoid fixation in cT3 laryngeal squamous cell carcinoma (SCC) is crucial for treatment planning. The aim of this retrospective study was to differentiate among possible causes of arytenoid fixation (edema, inflammation, mass effect, or tumor invasion) by analyzing related signal patterns of magnetic resonance (MR) in the posterior laryngeal compartment (PLC) and crico-arytenoid unit (CAU). Seventeen patients affected by cT3 glottic SCC with arytenoid fixation were preoperatively studied by state-of-the-art MR with surface coils. Read More

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http://dx.doi.org/10.3390/cancers11010067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356606PMC
January 2019
1 Read

Patterns of distant metastasis in head and neck cancer at presentation: Implications for initial evaluation.

Oral Oncol 2019 Jan 27;88:131-136. Epub 2018 Nov 27.

Department of Otolaryngology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.

Importance: Evaluation of distant metastasis (DM) is part of every new cancer evaluation. Understanding DM presentation patterns may impact the imaging workup of Head and Neck Squamous Cell Carcinoma (HNSCC).

Objective: Examine the frequency and location of DM at presentation in HNSCC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183043
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http://dx.doi.org/10.1016/j.oraloncology.2018.11.023DOI Listing
January 2019
1 Read

Case of metastatic small cell carcinoma of the oropharynx successfully treated with image-guided volumetric modulated arc therapy (IG-VMAT): pushing the limits of technology to match treatment intent.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Department of Radiation Oncology, Batra Hospital & Medical Research Centre, New Delhi, Delhi, India.

Extrapulmonary small cell carcinomas (EPSCC) are a rare subtype of neuroendocrine tumours which have been documented to arise from a multitude of sites and treatment outcomes are disappointing. The most common site involved in the head and neck region is the larynx and the oropharynx as a primary site has been infrequently reported. The patient presented with bilateral neck swelling and an ulcerated lesion was noted in the base of tongue (BOT). Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-226522
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http://dx.doi.org/10.1136/bcr-2018-226522DOI Listing
December 2018
4 Reads

Adenoid cystic carcinoma in ventricle of larynx: An interesting case.

Medicine (Baltimore) 2018 Dec;97(50):e13622

Department of Otolaryngology, First Affiliated Hospital, College of Medicine, Zhe Jiang University, Hangzhou.

Rationale: Adenoid cystic carcinomas (ACCs) are malignant tumors and occur in the major and the minor salivary glands. ACCs are rare in the larynx.

Patient Concerns: A 55-year-old female patient who presented with a 12 months history of paraesthesia pharynges and hoarseness for 4 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000013622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320204PMC
December 2018
2 Reads

Narrow band imaging in transoral laser microsurgery (TLM) in moderately advanced (T2, T3) glottic cancer.

Otolaryngol Pol 2018 Aug;72(5):17-23

Department of Otolaryngology, Head and Neck Surgery, Poznań University of Medical Sciences, Poznań, Poland.

Introduction: Treatment planning in T2, T3 laryngeal carcinoma is based on clinical assessment and radiological imaging. However, to delineate precise mucosal margins for transoral laser microsurgery (TLM), a high class, sophisticated endoscopy is indispensable. Narrowband imaging (NBI) which is an optical filter technology, seems to be a useful adjunctive tool in marking superficial margins. Read More

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http://dx.doi.org/10.5604/01.3001.0012.0486DOI Listing
August 2018
14 Reads

Efficacy of anti-PD-1 therapy in a patient with brain metastasis of parotid carcinoma: A case report.

Auris Nasus Larynx 2018 Nov 12. Epub 2018 Nov 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hirhoshima-shi, Hiroshima, 734-8551, Japan.

CheckMate 141, an open-label, randomized phase III trial of nivolumab, indicated that treatment with nivolumab prolonged overall survival of patients with platinum-refractory, recurrent head and neck squamous cell carcinoma. Herein, we describe a case of brain metastasis of parotid carcinoma in which a good response was achieved after nivolumab treatment. The patient was a 67-year-old woman with parotid carcinoma (cT4bN0M0) who received induction chemotherapy followed by chemoradiation. Read More

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http://dx.doi.org/10.1016/j.anl.2018.10.003DOI Listing
November 2018
3 Reads

Role of Imaging in Clinically Occult Isolated Intrathyroidal Metastasis from Squamous Cell Carcinoma of Tongue: An Unusual Case Series.

Indian J Nucl Med 2018 Oct-Dec;33(4):326-330

Department of Head and Neck Surgical Oncology, HCG Cancer Centre, Ahmedabad, Gujarat, India.

Metastasis to the thyroid gland is rare; furthermore, intrathyroid metastasis from head and neck squamous cell carcinoma (SCC) is very unusual, with only nine previously documented cases four from intrathyroid metastasis from nasopharyngeal carcinoma, two from oral cavity, one each from oropharynx, larynx, and parotid. The reported case series are unique in nature and illustrates the role of fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) and ultrasound-guided biopsy in diagnosing clinically occult isolated intrathyroidal metastasis, which helps in the best management for an isolated intrathyroid metastases. This study details the cases of three patients who were diagnosed with intrathyroidal metastasis from SCC of the tongue by PET-CT, followed by USG-guided biopsy, who were treated with either surgery and or chemotherapy. Read More

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http://www.ijnm.in/text.asp?2018/33/4/326/242930
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http://dx.doi.org/10.4103/ijnm.IJNM_106_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194773PMC
November 2018
2 Reads

A Critical Reappraisal of Primary and Recurrent Advanced Laryngeal Cancer Staging.

Ann Otol Rhinol Laryngol 2018 Oct 26:3489418806915. Epub 2018 Oct 26.

1 Division of Otorhinolaryngology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Objectives:: Laryngeal squamous cell carcinoma (LSCC) can involve different anatomic subunits with peculiar surgical and prognostic implications. Despite conflicting outcomes for the same stage of disease, the current staging system considers different lesions in a single cluster. The aim of this study was to critically discuss clinical and pathologic staging of primary and recurrent advanced LSCC in order to define current staging pitfalls that impede a precise and tailored treatment strategy. Read More

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http://dx.doi.org/10.1177/0003489418806915DOI Listing
October 2018
10 Reads

Is C-11 Methionine PET an alternative to 18-F FDG-PET for identifying recurrent laryngeal cancer after radiotherapy?

Clin Otolaryngol 2018 Oct 12. Epub 2018 Oct 12.

Department of Otorhinolaryngology - Head & Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Objective: 18F FDG-PET is superior to other imaging techniques in revealing residual laryngeal cancer after radiotherapy. Unfortunately, its specificity is low, due to FDG uptake in inflammation and in anaerobic conditions. PET imaging with the amino acid-based radiopharmaceutical C11-methionine (MET) should be less influenced by post-radiation conditions. Read More

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http://doi.wiley.com/10.1111/coa.13242
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http://dx.doi.org/10.1111/coa.13242DOI Listing
October 2018
2 Reads

Implementing Key Changes in the American Thyroid Association 2015 Thyroid Nodules/Differentiated Thyroid Cancer Guidelines Across Practice Types.

Endocr Pract 2018 09;24(9):833-840

Objective: This article provides suggestions to help clinicians implement important changes in the 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Carcinoma ("ATA 2015") across diverse settings.

Methods: Key ATA 2015 changes are summarized regarding: ( 1) thyroid nodule management; ( 2) lobectomy versus thyroidectomy for differentiated thyroid carcinoma (DTC); and ( 3) surveillance following primary treatment of DTC. Advice to facilitate implementation is based on clinical experience and selected literature. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0130
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http://dx.doi.org/10.4158/EP-2018-0130DOI Listing
September 2018
4 Reads

Neck Muscle Mass Index as a Predictor of Post-Laryngectomy Wound Complications.

Ann Otol Rhinol Laryngol 2018 Nov 9;127(11):841-847. Epub 2018 Sep 9.

8 Department of Otorhinolaryngology, Istanbul Aydın University, Istanbul, Turkey.

Objective: We investigated the relationship between paravertebral muscle cross-sectional area (PVM CSA) at the third vertebra (C3) level using computerized tomography (CT) neck images and its relationship with complications after total laryngectomy.

Design: Retrospective analysis of 60 advanced laryngeal cancer patients who underwent total laryngectomy was performed. The cross-sectional areas of paravertebral neck muscles using neck CT at C3 level images obtained preoperatively were analyzed. Read More

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http://dx.doi.org/10.1177/0003489418798660DOI Listing
November 2018
4 Reads

Synchronous Laryngeal Squamous Cell Carcinoma and Intrahepatic Cholangiocarcinoma Present in an Obese Male with Poor Prognosis.

Anticancer Res 2018 Sep;38(9):5547-5550

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Concurrent laryngeal squamous cell carcinoma and intrahepatic cholangiocarcinoma is rare and no prior report has been found through a PubMed search. Here we report such a case of a 51-year old obese male presenting with hoarseness and trouble swallowing for 2 to 3 months. Imaging findings of computer tomography (CT) and magnetic resonance imaging (MRI) with and without contrast were suspicious for a T3N2 supraglottic laryngeal cancer. Read More

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http://dx.doi.org/10.21873/anticanres.12890DOI Listing
September 2018
12 Reads

Multiple Subcutaneous Nodules Leading to Diagnosis of Colon Cancer.

Middle East J Dig Dis 2018 Jul 25;10(3):188-191. Epub 2018 Apr 25.

Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Skin metastases from colorectal carcinoma are rare and signal advanced disease. Skin metastasis refers to growth of cancer cells in the skin originating from an internal cancer. In most cases, cutaneous metastasis develops after the initial diagnosis of the primary internal malignancy and late in the course of the disease. Read More

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http://dx.doi.org/10.15171/mejdd.2018.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119832PMC
July 2018
19 Reads

Prognostic value of F-FDG PET/CT parameters in patients who undergo salvage treatments for recurrent squamous cell carcinoma of the larynx and hypopharynx.

J Surg Oncol 2018 Sep 21;118(4):644-650. Epub 2018 Aug 21.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Recurrent laryngeal/hypopharyngeal squamous cell carcinoma (LHSCC) is commonly associated with poor survival outcomes. We evaluated the prognostic role of F-fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT) parameters quantitatively measured in patients who underwent salvage treatments for recurrent LHSCC.

Methods: This study involved 100 consecutive LHSCC patients who underwent F-FDG PET/CT for recurrent staging and subsequent salvage treatments. Read More

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http://doi.wiley.com/10.1002/jso.25185
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http://dx.doi.org/10.1002/jso.25185DOI Listing
September 2018
27 Reads

Thyroid metastasis from rectal adenocarcinoma.

BMJ Case Rep 2018 Aug 14;2018. Epub 2018 Aug 14.

Section of Endocrinology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

The thyroid is a rare site for metastasis, occurring in 0.1% of colorectal cases. A 46-year-old man with rectal adenocarcinoma developed an enlarging anterior neck mass and increasing carcinoembryonic antigen 2 years after curative intent treatment. Read More

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http://dx.doi.org/10.1136/bcr-2018-225549DOI Listing
August 2018
4 Reads

Cortactin as a potential predictor of second esophageal neoplasia in hypopharyngeal carcinoma.

Auris Nasus Larynx 2018 Aug 11. Epub 2018 Aug 11.

Department of Radiation Oncology, Medical Imaging and Radiological Sciences, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.

Objective: Hypopharyngeal carcinoma has a very poor prognosis. The high incidence of second esophageal neoplasia is one of the major causes. To establish an efficient follow-up scheme for increasing the diagnostic yield and reducing the adverse impact of second esophageal neoplasia on survival, the purpose of this study was to explore a biomarker to predict second esophageal neoplasia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03858146183049
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http://dx.doi.org/10.1016/j.anl.2018.08.002DOI Listing
August 2018
13 Reads

Verification of HE-based CTV in laryngeal and hypopharyngeal cancer using pan-cytokeratin.

Clin Transl Radiat Oncol 2018 Aug 11;12:21-27. Epub 2018 Jul 11.

Department of Radiotherapy, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.

Background: For accurate target definition, we determined margins for the clinical target volume (CTV) for laryngeal and hypopharyngeal cancer in computed tomography (CT, 4.3 mm), magnetic resonance imaging (MR, 6.1 mm) and fluorodeoxyglucose (FDG)-positron emission tomography (PET, 5. Read More

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http://dx.doi.org/10.1016/j.ctro.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077173PMC
August 2018
1 Read

Staging of Laryngeal and Hypopharyngeal Cancer: Computed Tomography versus Histopathology.

Iran J Otorhinolaryngol 2018 Jul;30(99):189-194

Department of Otorhinolaryngology, Kasturba Medical College, Mangalore, MAHE. India.

Introduction: Computed tomography (CT) imaging is the choice of investigation for evaluation of extent of tumor under the mucosa, locally and regionally. This study was undertaken to assess the accuracy of preoperative CT imaging in the staging of carcinoma of the larynx and hypopharynx.

Materials And Methods: In this retrospective study, all cases who were clinically (c) staged T3-T4 and who underwent surgery were evaluated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064760PMC
July 2018
1 Read

The role of tumor DNA as a diagnostic tool for head and neck squamous cell carcinoma.

Semin Cancer Biol 2018 Aug 3. Epub 2018 Aug 3.

Section of Otolaryngology-Head and Neck Surgery, University of Chicago Medicine, Chicago, IL, United States. Electronic address:

Head and neck squamous cell carcinoma (HNSCC) represents the most common type of head and neck cancer worldwide. However, despite advances in cancer care globally there has been little progress in HNSCC, with survival remaining static and slightly worse in laryngeal squamous cell carcinoma with 5 year survivals remaining at ∼50%. Conventional analysis of tissue through cytopathology or histopathology are the mainstay of diagnosis. Read More

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http://dx.doi.org/10.1016/j.semcancer.2018.07.008DOI Listing
August 2018
6 Reads

An unusual case of a glottic carcinoma metastasis to the tracheal lumen.

Ecancermedicalscience 2018 3;12:846. Epub 2018 Jul 3.

2nd Department of Otorhinolaryngology-Head and Neck Surgery, Aristotle University of Thessaloniki, Papageorgiou Hospital, 54629 Thessaloniki, Greece.

Various mechanisms such as second primary lesion, tumour seeding or lymphogenous and haematogenous metastasis could be proposed to explain the nature of dual malignant lesions. We report the case of a glottic laryngeal carcinoma combined with a secondary endotracheal tumour. Following the imaging modalities, the patient underwent total laryngectomy and wide excision of the trachea. Read More

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https://www.ecancer.org/journal/12/full/846-an-unusual-case-
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http://dx.doi.org/10.3332/ecancer.2018.846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057660PMC
July 2018
12 Reads

The interobserver agreement in the detection of recurrent HNSCC using MRI including diffusion weighted MRI.

Eur J Radiol 2018 Aug 31;105:134-140. Epub 2018 May 31.

Department of Radiotherapy, University Medical Center Utrecht, University Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Introduction: For the detection of local recurrences of head and neck squamous cell carcinomas (HNSCC) after (chemo)radiation, diagnostic imaging is generally performed. Diffusion weighted magnetic resonance imaging (DW-MRI) has been proven to be able to adequately diagnose the presence of cancer. However evaluation of DW-MR images for recurrences is difficult and could be subject to individual interpretation. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.05.031DOI Listing
August 2018
3 Reads

Acute presentation of a partially obstructing laryngeal tumour: adjuvant agents to gaseous induction of anaesthesia.

BMJ Case Rep 2018 Jul 12;2018. Epub 2018 Jul 12.

Anaesthetics, Royal Derby Hospital, Derby, UK.

We present the case of a 53-year-old man who attended our emergency department with stridor. He had recently undergone investigation for possible glottic cancer. We discuss the airway management of such a case. Read More

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http://dx.doi.org/10.1136/bcr-2018-224700DOI Listing
July 2018
10 Reads

Improvements in High Resolution Laryngeal Magnetic Resonance Imaging for Preoperative Transoral Laser Microsurgery and Radiotherapy Considerations in Early Lesions.

Front Oncol 2018 6;8:216. Epub 2018 Jun 6.

C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.

As the benefits, limitations, and contraindications of transoral laser microsurgery (TLM) in glottic carcinoma treatments become better defined, pretreatment imaging has become more important to assess the case-specific suitability of TLM and to predict functional outcomes both for treatment consideration and patient counseling. Magnetic resonance imaging (MRI) is the preferred modality to image such laryngeal tumors, even though imaging the larynx using MRI can be difficult. The first challenge is that there are no commercial radiofrequency (RF) coils that are specifically designed for imaging the larynx, and performance in terms of coverage and signal-to-noise ratio is compromised using general-purpose RF coils. Read More

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http://dx.doi.org/10.3389/fonc.2018.00216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997776PMC
June 2018
3 Reads

An investigation into symptoms, diagnosis, treatment, and treatment complications in patients with retrosternal goiter.

J Family Med Prim Care 2018 Jan-Feb;7(1):224-229

Inflammatory Lung Disease Research Center, School of Medicine, Razi Hospital, Guilan University of Medical Science, Rasht, Iran.

Introduction: Retrosternal goiter refers to any thyroid enlargement in which over 50% of the thyroid permanently located under the thoracic inlet or the lower pole of thyroid is not palpable with the neck in hyperextended position. Due to the increasing number of surgical procedures of retrosternal goiter, the present study was carried out to examine the symptoms, diagnosis, treatment, and treatment complications in retrosternal goiter patients.

Materials And Methods: Data related to demographic data (age and gender), clinical symptoms (dyspnea, dysphagia, dysphonia, lumps in neck, and hoarseness), methods of diagnosis (computed tomography [CT], chest X-ray [CXR], ultrasonography, and magnetic resonance imaging), and postoperative complications (bleeding, early and late dysphonia, early and late dyspnea, transient and permanent hypocalcemia, transient, and permanent recurrent laryngeal nerve paralysis) were collected. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_286_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958574PMC
June 2018
13 Reads

Laryngeal Tuberculosis Mimicking Laryngeal Carcinoma on F-FDG PET/CT Imaging.

Mol Imaging Radionucl Ther 2018 Jun;27(2):81-83

Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydın, Turkey.

Laryngeal tuberculosis is a rare presentation of tuberculosis. It can mimic laryngeal carcinoma with its clinical and imaging findings. A 51-year old woman underwent F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) imaging for clinically suspected carcinoma of the larynx. Read More

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http://dx.doi.org/10.4274/mirt.44366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996607PMC
June 2018
9 Reads

Oncological and functional outcomes of transoral laser surgery for laryngeal carcinoma.

Eur Arch Otorhinolaryngol 2018 Aug 5;275(8):2071-2077. Epub 2018 Jun 5.

Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Av. Roma SN, 33011, Oviedo, Asturias, Spain.

Introduction: Transoral laser microsurgery (TLM) has become the standard approach for treatment of early-stage laryngeal carcinoma in most institutions due to their good oncological and functional results with few local complications. The purpose of this study was to analyze the oncological and functional results of TLM in the treatment of laryngeal tumors at our Hospital.

Materials And Methods: Patients with laryngeal squamous cell carcinoma (LSCC) treated from 1998 to 2013 with TLM with curative intention, and with a minimum follow-up of 24 months, were reviewed. Read More

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http://link.springer.com/10.1007/s00405-018-5027-z
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http://dx.doi.org/10.1007/s00405-018-5027-zDOI Listing
August 2018
3 Reads

A phase II randomized trial comparing neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in advanced squamous cell carcinoma of the pharynx or larynx.

Biomed J 2018 04 21;41(2):129-136. Epub 2018 May 21.

Division of Medical Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: To clarify the effect of induction chemotherapy (ICT) in patients with advanced pharyngeal and laryngeal squamous cell carcinoma (PLSCC) treated with concurrent chemoradiotherapy (CCRT).

Methods: Patients with treatment-naïve nonmetastatic advanced PLSCC were stratified according to disease stage (III or IV) and resectability before being randomized to either a ICT/CCRT or CCRT arm. A cisplatin/tegafur-uracil/leucovorin regimen was administered during ICT and CCRT. Read More

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http://dx.doi.org/10.1016/j.bj.2018.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138767PMC
April 2018
2 Reads

Assessment of tumor response to chemoradiotherapy and predicting prognosis in patients with head and neck squamous cell carcinoma by PERCIST.

Ann Nucl Med 2018 Aug 1;32(7):453-462. Epub 2018 Jun 1.

Department of Radiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.

Purpose: To evaluate therapeutic response to chemoradiotherapy and prediction of recurrence and death in patients with head and neck squamous cell carcinoma (HNSCC) using Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST).

Materials And Methods: Forty-two patients (mean 63.4, range 20-79 years) with nasopharyngeal (n = 10), oropharyngeal (n = 13), hypopharyngeal (n = 11), or laryngeal (n = 8) cancer underwent fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) before and approximately 3 months (mean 95. Read More

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http://dx.doi.org/10.1007/s12149-018-1267-7DOI Listing
August 2018
3 Reads

[The relationship between ¹⁸F-FDG uptake and oncogene in human laryngeal squamous cell carcinoma transplantation tumor animal model].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jul;31(14):1108-1112

Department of Otorhinolaryngology Head Neck Surgery, Bethune International Peace Hospital.

The aim of this study is to explore the relationship between [F18] fluoro 2 deoxy d glucose ¹⁸F-FDG) uptake and oncogene expression in human laryngeal squamous cell carcinoma (LSCC) transplantation tumor.Ten nude mice were randomly divided into two groups, 5 mice of each group. One group was injected subcutaneously with Hep-2 cells to establish xenograft model, and the other one was injected with HIF-RNAi-Hep-2 cells. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.14.014DOI Listing

Prophylactic Central Compartment Neck Dissection in Papillary Thyroid Cancer and Effect on Locoregional Recurrence.

Ann Surg Oncol 2018 Sep 21;25(9):2526-2534. Epub 2018 May 21.

Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University, Nashville, TN, USA.

Background: Prophylactic central compartment neck dissection (pCCND) in addition to total thyroidectomy (TT) includes removal of central compartment lymph nodes in the absence of clinical involvement on preoperative and intraoperative evaluation. The data regarding the influence of pCCND on oncologic outcomes and surgical complication rates is mixed and, therefore, is the focus of this analysis.

Methods: A systematic review of the literature on total thyroidectomy with prophylactic central compartment neck dissection (TT + pCCND) from January 1990 to October 2017 identified 221 abstracts of which 17 met inclusion criteria and were reviewed (1 randomized-control trial, 13 retrospective cohort studies, and 3 meta-analyses). Read More

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http://dx.doi.org/10.1245/s10434-018-6528-0DOI Listing
September 2018
3 Reads

Successful treatment switch from lenvatinib to sorafenib in a patient with radioactive iodine-refractory differentiated thyroid cancer intolerant to lenvatinib due to severe proteinuria.

Auris Nasus Larynx 2018 Dec 18;45(6):1249-1252. Epub 2018 May 18.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan; Kobe University Hospital Cancer Center, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. Electronic address:

Sorafenib and lenvatinib showed efficacy for patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) in pivotal phase 3 clinical trials. Although the efficacy of lenvatinib in patients who received previous treatment with multi-target kinase inhibitors (m-TKIs), including sorafenib, was reported, the efficacy of sorafenib in patients who previously received lenvatinib remains unknown. A 75-year-old woman diagnosed as RAI-refractory poorly differentiated carcinoma with multiple lung metastases and started treatment with lenvatinib. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03858146183030
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http://dx.doi.org/10.1016/j.anl.2018.05.003DOI Listing
December 2018
10 Reads

Long non-coding RNA biomarker for human laryngeal squamous cell carcinoma prognosis.

Gene 2018 May 15. Epub 2018 May 15.

EagleImmune, Inc., 11361 Bishops Gate Ln, Laurel, MD 20723, USA. Electronic address:

Long non-coding RNAs (lncRNA) were discovered in tumors. The regulation of lncRNA in human laryngeal squamous cell carcinoma (LSCC) remains incomplete. Uncovering the potential of lncRNA to stratify the prognosis of LSCC and streamline the vast amount of clinical information will affect medical interventions. Read More

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http://dx.doi.org/10.1016/j.gene.2018.05.046DOI Listing
May 2018
1 Read

[Role of narrow band imaging in the detection of malignant lesions of the oropharynx and the laryngopharynx].

Authors:
J H Wu X Y Luo

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 May;32(9):665-668

Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Xiamen University, Xiamen, 361000, China.

To explore the role of narrow band imaging (NBI) endoscopy in the diagnosis of oropharyngeal and laryngopharyngeal lesions. NBI and white light (WLI) endoscopy were performed on 90 patients with oropharyngeal and laryngopharyngeal lesions from August 2016 to May 2017. NBI findings were classified into 5 types according to the Ni classification and were compared with histopathological results. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.09.006DOI Listing

Lingual Thyroid Carcinoma: A Case Report and Review of Surgical Approaches in the Literature.

Ann Otol Rhinol Laryngol 2018 Jul 16;127(7):475-480. Epub 2018 May 16.

1 West Virginia University, School of Medicine, Department of Otolaryngology-Head and Neck Surgery, Morgantown, West Virginia, USA.

Introduction: Lingual thyroid cancer is a rare entity with a paucity of literature guiding methods of surgical treatment. Its location presents anatomic challenges with access and excision.

Objective: We present a case of T4aN1b classical variant papillary thyroid carcinoma of the lingual thyroid that was removed without pharyngeal entry. Read More

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http://dx.doi.org/10.1177/0003489418774070DOI Listing
July 2018
8 Reads

Treatment of differentiated thyroid cancer: can endoscopic thyroidectomy via a chest-breast approach achieve similar therapeutic effects as open surgery?

Surg Endosc 2018 May 14. Epub 2018 May 14.

Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.

Background: An analysis of some special factors was performed to further evaluate and discuss whether endoscopic surgery and traditional open surgery have similar therapeutic outcomes for differentiated thyroid cancer (DTC).

Methods: A retrospective study was performed on 76 patients undergoing surgery to treat DTC. Forty patients were treated by endoscopic thyroidectomy via the chest-breast approach (endoscopic group) and thirty-six patients were treated by open surgery (open group). Read More

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http://dx.doi.org/10.1007/s00464-018-6221-1DOI Listing
May 2018
11 Reads

Total lesion glycolysis on FDG-PET/CT before salvage surgery predicts survival in laryngeal or pharyngeal cancer.

Oncotarget 2018 Apr 10;9(27):19115-19122. Epub 2018 Apr 10.

Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.

We investigated whether 18F-fluorodeoxyglucose uptake parameters using positron emission tomography combined with computed tomography predicts several survival outcomes, including lung metastasis-free survival, in patients with laryngeal or pharyngeal cancer who underwent salvage surgery. The maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were calculated as 18F-fluorodeoxyglucose uptake parameters in 51 patients with laryngeal or pharyngeal cancer before salvage surgery. In univariate analysis, the maximum standardized uptake value ≥ 22. Read More

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http://dx.doi.org/10.18632/oncotarget.24914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922381PMC
April 2018
4 Reads

Comparison of narrow band imaging and the Storz Professional Image Enhancement System for detection of laryngeal and hypopharyngeal pathologies.

Eur Arch Otorhinolaryngol 2018 Jul 30;275(7):1819-1825. Epub 2018 Apr 30.

Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Ostrava, 17. listopadu 1790, 708 52, Ostrava, Czech Republic.

Objective: The aim of this study was to compare narrow band imaging (NBI) endoscopy and Storz Professional Image Enhancement System (SPIES) in observing epithelial and/or subepithelial microvascular irregularities and pathologies.

Methods: A total of 73 patients with laryngeal or hypopharyngeal lesions were investigated using high-definition NBI endoscopy preoperatively in local anesthesia and using SPIES system intraoperatively in general anesthesia from August 2016 to October 2017. Superficial vascular structures were classified preoperatively (NBI) and intraoperatively (SPIES) according to descriptive guidelines of vascular changes by Arens. Read More

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http://dx.doi.org/10.1007/s00405-018-4987-3DOI Listing
July 2018
2 Reads

mRECIST criteria to assess recurrent thyroid carcinoma treatment response after radiofrequency ablation: a prospective study.

J Endocrinol Invest 2018 Dec 23;41(12):1389-1399. Epub 2018 Apr 23.

Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine, University of Pisa, Via Paradisa, 2, Cisanello Hospital, 56100, Pisa, Italy.

Purpose: Surgical removal is recommended for recurrent thyroid carcinomas (RTCs) unable to uptake radioiodine and/or not responsive to chemotherapy. However, repeated neck dissection is difficult for surgeons. Thus, radiofrequency ablation (RFA) was proposed for RTCs. Read More

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http://dx.doi.org/10.1007/s40618-018-0886-0DOI Listing
December 2018

Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer.

Oral Oncol 2018 Apr 10;79:1-8. Epub 2018 Feb 10.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Objectives: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies.

Materials And Methods: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880303PMC
April 2018
19 Reads

The role of intraoperative narrow-band imaging in transoral laser microsurgery for early and moderately advanced glottic cancer.

Braz J Otorhinolaryngol 2018 Mar 1. Epub 2018 Mar 1.

Poznan University of Medical Sciences, Department of Otolaryngology, Head and Neck Surgery, Poznan, Poland.

Introduction: Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer.

Objective: The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the larynx mucosa in terms of specifying surgical margins.

Methods: Forty-four consecutive T1-T2 glottic cancers treated with trans-oral laser microsurgery Type I-VI cordectomy were presented. Read More

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http://dx.doi.org/10.1016/j.bjorl.2018.01.004DOI Listing
March 2018
14 Reads

Clinical features of nasal and sinonasal inverted papilloma associated with malignancy.

Auris Nasus Larynx 2018 Oct 13;45(5):1014-1019. Epub 2018 Mar 13.

Department of Otolaryngology, Head and Neck Surgery, Kurashiki Central Hosipital, 1-1-1 Miwa, Kurashiki, Okayama 710-8602, Japan.

Objective: Nasal and sinonasal inverted papilloma (IP) are rare benign tumors and have the potential to exhibit malignancy in approximately 10% of cases. This study aimed to analyze the clinical features of IP associated with malignancy. Furthermore, we reviewed our therapeutic strategy and the clinical course of malignant IP. Read More

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http://dx.doi.org/10.1016/j.anl.2018.02.009DOI Listing
October 2018
5 Reads

The value of whole-body contrast-enhanced 18F-FDG PET/CT imaging in the diagnosis and staging of patients with laryngeal carcinoma.

Nucl Med Commun 2018 Apr;39(4):334-342

Otorhinolaryngology, Istanbul Training and Research Hospital, University of Health Sciences.

Purpose: This study aimed to determine whether intravenous contrast-enhanced dual-phase fluorine-18--fluorodeoxyglucose (F-FDG) PET/CT scans provide additional diagnostic information compared with the MRI/CT in patients with laryngeal carcinoma during the initial staging.

Patients And Methods: Forty-five consecutive patients (44 men, one woman; mean age±SD, 67.0±9. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000809DOI Listing
April 2018
6 Reads

Preradiotherapy Tumor Volume in Local Control of Squamous Cell Carcinoma of the Supraglottic Larynx.

Am J Clin Oncol 2018 Mar 8. Epub 2018 Mar 8.

Departments of Radiation Oncology.

Objectives: Examine the utility of pretreatment computed tomography in predicting local control (LC) in squamous cell carcinoma of the supraglottic larynx treated with primary radiotherapy (RT).

Methods: In total, 167 patients treated between 1983 and 2013 were reviewed. Patients had received pretreatment diagnostic computed tomographic imaging of the larynx and neck from which primary tumor volume (PrTV) was delineated. Read More

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http://dx.doi.org/10.1097/COC.0000000000000437DOI Listing
March 2018
6 Reads

Morphometric computer-assisted image analysis of epithelial cells in different grades of oral squamous cell carcinoma.

J Cancer Res Ther 2018 Jan-Mar;14(2):361-367

Department of Oral and Maxillofacial Pathology, Sri Siddhartha Dental College and Hospital, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, India.

Introduction: Oral squamous cell carcinoma (OSCC) accounts 94% of all malignant lesions in the oral cavity. In the assessment of OSCC, nowadays the WHO grading system has been followed widely but due to its subjectivity, investigators applied the sophisticated technique of computer-assisted image analysis in the grading of carcinoma in larynx, lungs, esophagus, and cervix to make it more objective.

Aims And Objectives: Access, analyze, and compare the cellular area (CA); cytoplasmic area (Cyt A); nuclear area (NA); nuclear perimeter (NP); nuclear form factor (NF); and nuclear-cytoplasmic ratio (N/C) of the cells in different grades of OSCC. Read More

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http://dx.doi.org/10.4103/0973-1482.189423DOI Listing
August 2018
11 Reads

Human papillomavirus infection is not associated with laryngeal squamous cell carcinoma in Taiwan.

J Microbiol Immunol Infect 2018 Feb 21. Epub 2018 Feb 21.

Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:

Background/purpose: To examine whether the prevalence rate of human papillomavirus (HPV) infection in Taiwanese patients with primary laryngeal squamous cell carcinoma (LSCC) is different from that in those with a vocal polyp (VP) or vocal fold leukoplakia (VFL).

Methods: This prospective cohort study recruited 41 consecutive patients with primary LSCC and 27 and 20 patients with VP and VFL, respectively. The HPV L1 gene in surgical specimens was detected using polymerase chain reaction. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.02.002DOI Listing
February 2018
4 Reads

Immune cell infiltration in head and neck squamous cell carcinoma and patient outcome: a retrospective study.

Acta Oncol 2018 Sep 1;57(9):1165-1172. Epub 2018 Mar 1.

a Center for Molecular Imaging, Radiotherapy and Oncology (MIRO) , Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain , Brussels , Belgium.

Background: Human papillomavirus (HPV) prevalence in oropharynx squamous cell carcinoma (OPSCC) is on the rise. HPV-linked OPSCCs represent a distinct clinical entity with a better treatment response and patient survival compared to tumors not linked to HPV. An emerging role in treatment response has been attributed to immune cell infiltration in human tumors. Read More

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http://dx.doi.org/10.1080/0284186X.2018.1445287DOI Listing
September 2018
4 Reads