Search Our Scientific Publications & Authors

J Clin Lab Anal 2019 Apr 19:e22899. Epub 2019 Apr 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Lihuili Hospital of Ningbo University, Ningbo, China.

Background: Estrogen-related receptor gamma (ESRRG) has been identified as a tumor suppressor gene in several cancers. We aimed to evaluate ESRRG promoter methylation in laryngeal squamous cell carcinoma (LSCC) and its relative clinical value in LSCC.

Methods: Bisulfite pyrosequencing assays were performed on 91 pairs of tumor and paracancer tissues from LSCC patients in China. Read More

Clin Sci (Lond) 2019 Apr 16. Epub 2019 Apr 16.

The Second Affiliated Hospital, Harbin Medical University, Harbin, China.

Background: Circular RNAs (circRNAs) are a class of non-coding RNAs broadly expressed in cells of various species. However, the molecular mechanisms that link circRNAs with Laryngeal squamous cell carcinoma (LSCC) are not well understood. In the present study, we attempted to provide novel basis for targeted therapy for LSCC from the aspect of circRNA-miRNA-mRNA interaction. Read More

Oncol Lett 2019 May 4;17(5):4717-4725. Epub 2019 Mar 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, P.R. China.

Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent types of head and neck malignancies. Advanced LSCC has failed to demonstrate a satisfactory prognosis, despite the progresses in the diagnosis and treatment, and the optimal treatment modality continues to be debated. To evaluate the clinical utility and survival outcomes of adjuvant chemoradiotherapy (CRT) for patients with resected advanced LSCC, a retrospective analysis of 232 patients with LSCC who had undergone total laryngectomy and neck dissection between 2005 and 2010 was conducted. Read More

J Cell Physiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Oncology, RenMin Hospital of Wuhan University, Wuhan, China.

Cancer stem cells (CSCs) have been recognized as the significant cause of tumor recurrence. Long noncoding RNAs (lncRNAs) are involved in various cancers, including human laryngeal cancer. So far the correlation between lncRNA DiGeorge syndrome critical region gene 5 (DGCR5) and CSC-like properties in human laryngeal cancer remains barely known. Read More

Am J Otolaryngol 2019 Apr 3. Epub 2019 Apr 3.

Department of Vascular Surgery, University General Hospital "Attikon", Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: Laryngeal squamous cell carcinoma (LSCC), a common type of head and neck cancer, is associated with high rates of metastasis and recurrence. In this study, we investigated the potential combinatorial prognostic value of NOTCH1, Vimentin (VIM), and Metastasis-associated 1 (MTA1) protein in LSCC, using immunohistochemistry.

Materials And Methods: Tissue specimens from 69 patients with LSCC were immunohistochemically evaluated for the protein expression of NOTCH1, VIM, and MTA1. Read More

J Laryngol Otol 2019 Apr 12:1-9. Epub 2019 Apr 12.

Department of Medical Biochemistry,Acibadem Mehmet Aydinlar University,Ankara,Turkey.

Objective: To assess published reports of oncological surgical success rates in patients who underwent transoral laser supraglottic surgery and robotic surgery for supraglottic cancer.

Methods: A systematic review of the literature was conducted and a meta-analysis of published data was performed. PubMed, Sage, Medline and Cochrane data sources were investigated. Read More

Front Oncol 2019 26;9:191. Epub 2019 Mar 26.

Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany.

Induction chemotherapy (ICT) is an attractive option for advanced head and neck squamous cell carcinoma (HNSCC) patients which has been prospectively evaluated in the context of a multimodality treatment approach. The theoretical benefit is the ability to suppress distant metastases and shrink the tumor while chemotherapy is better tolerated when given sequentially than concurrently. However, clinical trials have failed to show consistent benefit of ICT over concurrent radio-chemotherapy and due to so far lacking level 1 evidence ICT outside larynx organ preservation remains rather investigational. Read More

Ear Nose Throat J 2019 Apr 9:145561319840826. Epub 2019 Apr 9.

1 Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA, USA.

Necrotizing sialometaplasia (NSM) is a benign, reactive metaplastic condition of the minor salivary gland tissue typically seen in the setting of injury, chemical or traumatic, and is nonneoplastic and self-limited. The diagnosis may be challenging as it may clinically mimic malignancy. We present the case of a 74-year-old male with a 1 pack per day smoking history for 60 years who presented with a reported 20-pound weight loss, dysphagia, and dysphonia progressing over the course of 6 months and found to have a 3. Read More

Auris Nasus Larynx 2019 Apr 5. Epub 2019 Apr 5.

Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan.

Malignancies have been reported to occasionally arise in scar tissue following injury. One hypothesis involves prolonged overactivation of tissue repair systems due to chronic inflammation and irritation, although the pathogenesis of cancers occurring in scars is not fully understood. We describe here two cases with a history of maxillary fracture at the site where squamous cell carcinoma (SCC) subsequently developed. Read More

Anticancer Agents Med Chem 2019 Apr 8. Epub 2019 Apr 8.

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, ( Constituent college of JSS Academy of Higher Education & Research, Deemed University) Udhagamandalam - 643001 (Tamilnadu). India.

9-anilinoacridines are acting as DNA-intercalating agents which plays an important role as antitumor drugs, due to their anti-proliferative properties. Some anticancer agents contain 9-anilinoacridines such as amsacrine (m-AMSA), and nitracrine (Ledakrine) have been already developed. In this study, novel 9-anilinoacridines substituted with thiazines 4a-r were designed, synthesized, characterized by physical and spectral data and their cytotoxic activities against DLA cell lines were evaluated. Read More

Ear Nose Throat J 2019 Apr 8:145561319839790. Epub 2019 Apr 8.

1 Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta, GA, USA.

Background: A lymph node yield (LNY) over 20 is considered a quality metric for lateral neck dissection to ensure an oncologic representative sample. Anecdotally, however, LNY in patients undergoing neck dissection after radiation therapy (RT) is lower due to atrophy and fibrosis.

Objective: To determine whether preoperative RT decreases LNY in patients with laryngeal cancers undergoing surgery. Read More

Cancers (Basel) 2019 Apr 7;11(4). Epub 2019 Apr 7.

Medical Oncology Service, University Hospital of Salamanca-IBSAL, 37007 Salamanca, Spain.

Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis). Read More

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of Biochemistry, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.

Zinc finger E‑box binding homeobox 2 (ZEB2) is a member of the Zfh1 family of two‑handed zinc finger/homeodomain proteins. To date, the role of ZEB2 in human laryngeal carcinoma has not been clearly defined. In the present study, the level of ZEB2 expression in laryngeal squamous cell carcinoma (LSCC) tissues and adjacent normal tissues was evaluated using reverse transcription‑quantitative polymerase chain reaction. Read More

Int Arch Otorhinolaryngol 2019 Apr 1;23(2):172-177. Epub 2019 Mar 1.

Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

 Acute carotid blowout syndrome (aCBS) is a severe complication of head and neck cancer (HNC). It can be defined as a rupture of the extracranial carotid arteries, or one of their branches, that causes life-threatening hemorrhage, and which nowadays can be treated with urgent endovascular intervention.  We retrospectively evaluate the endovascular management of aCBS and its outcome in years of survival. Read More

Braz J Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Erciyes University Medical Faculty, Department of Radiology, Kayseri, Turkey.

Introduction: Squamous cell carcinoma is the most common laryngeal neoplasm and accounts for approximately 95% of all malignant neoplams of the larynx. However, various benign and malignant tumors and inflammatory diseases may affect the larynx.

Objective: The purpose of this study is to analyze the clinical and imaging findings of non-squamous cell neoplasms and inflammatory diseases of the larynx. Read More

Auris Nasus Larynx 2019 Apr 3. Epub 2019 Apr 3.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Lymph node metastasis from signet ring cellcarcinoma (SRCC) primary unknown is extremely rare. We here report a case of primary-unknown SRCC that metastasized to the cervical lymph nodes, co-existing with mucoepidermoid carcinoma (MEC) of the parotid gland as a simultaneous double cancer. A 68-year-old female patient with right swollen cervical lymph nodes consulted our medical center. Read More

Diagn Cytopathol 2019 Apr 5. Epub 2019 Apr 5.

Department of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Adenoid cystic carcinoma (ACC) is most often primary in the major and minor salivary glands but can also arise from the submucosal seromucinous glands of the larynx and trachea. We report a case of ACC of the larynx that presented as a recurrent cough for 4 months and vomiting 3 to 4 times within 1 month. Fine-needle aspiration cytology was consistent with an ACC. Read More

Laryngoscope 2019 Apr 5. Epub 2019 Apr 5.

Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center & Feist-Weiller Cancer Center, Shreveport, Louisiana, U.S.A.

Indian J Cancer 2019 Jan-Mar;56(1):35-36

Department of Radiation Oncology, Max Superspeciality Hospital, Delhi, India.

Indian J Cancer 2019 Jan-Mar;56(1):29-34

Department of Radiation Oncology, Baskent University Adana Treatment and Research Center, Adana, Turkey.

Introduction: Second primary malignancy (SPM) is associated with decreased overall survival (OS) in laryngeal carcinomas (LC).

Methods: One hundred eighty three LC patients were analyzed retrospectively. The primary and secondary endpoints were the incidence of SPM and the OS difference between patients with and without SPM. Read More

Indian J Cancer 2019 Jan-Mar;56(1):4-8

Department of Medical Oncology, Ege University, Izmir, Turkey.

Background And Aim: The combination of cetuximab with platinum and 5-fluorouracil (5-FU) chemotherapy prolongs survival in patients with metastatic or recurrent squamous-cell carcinoma of the head and neck (SCCHN). Biweekly (once in 2 weeks) administration of cetuximab requires fewer hospital visits and decreases treatment costs; therefore, it is more convenient both for the patients and for the healthcare providers. Here, we assessed the efficacy, safety, and tolerability of an alternative biweekly regimen of cetuximab in combination with platinum and 5-FU chemotherapy as a first-line treatment for these patients. Read More

Indian J Surg Oncol 2019 Mar 26;10(1):210-212. Epub 2018 Nov 26.

Department: Surgical Oncology and Pathology, Bhagwan Mahaveer Cancer Hospital and Research Center, JLN Road, Jaipur, Rajasthan 302017 India.

Usual sites of the spread of the squamous cell carcinoma (SCC) larynx is regional-cervical lymphadenopathy. The lung is the most frequent site of distant metastasis, accounting for 66% of distant metastasis. Other metastatic sites include bone (22%), liver (10%), skin, mediastinum, and bone marrow. Read More

Tissue Cell 2019 Apr 22;57:84-89. Epub 2019 Feb 22.

Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt; Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia. Electronic address:

Laryngeal cancer was identified as the second most common respiratory system malignancy with squamous cell carcinoma being the most common malignant tumor of the larynx. Larynx being a secondary sex organ showing physiological changes during puberty, raises inquiry about the relationship between sex hormones receptors as estrogen receptors (ER), progesterone receptors (PR), androgen receptors (AR) and the development of laryngeal carcinoma. This study was carried out in cancer tissue samples from 50 patients with laryngeal squamous cell carcinoma. Read More

Adv Otorhinolaryngol 2019 12;83:35-46. Epub 2019 Feb 12.

Department of Radiology, University of Brescia, Brescia, Italy.

Pre-treatment clinical and radiological evaluations represent a key step in the proper management of hypopharyngeal carcinoma. First, office-based endoscopy allows the assessment of superficial tumor extension, signs of laryngeal infiltration, and the overall residual function of the laryngo-hypopharyngeal complex. Different tools, maneuvers, and techniques can improve this essential diagnostic step and should be considered a prerequisite to direct subsequent investigations and give an initial indication for the most appropriate treatment. Read More

Adv Otorhinolaryngol 2019 12;83:27-34. Epub 2019 Feb 12.

Department of Otolaryngology, Head and Neck Surgery, Nottingham University Hospital NHS Trust, Queens Medical Centre Campus, Nottingham, United Kingdom.

Patients with hypopharyngeal cancers frequently present at advanced stage and in poor general health status. Their natural history is characterised by diffuse local primary disease, mucosal and submucosal spread, early cervical nodal metastasis, and a relatively high rate of distant spread. By the time of initial diagnosis, some 60% of all hypopharyngeal cancer patients will be with stage IV disease, some 5% will present with distant metastases, and almost 40% will have a significant reduction in performance status. Read More

Adv Otorhinolaryngol 2019 12;83:126-134. Epub 2019 Feb 12.

University Department of Otolaryngology, Ninewells Hospital and Medical School, Dundee, United Kingdom,

Quality of life (QoL) is an important consideration in the management of individuals with head and neck cancer. The poor prognosis and significant impact of treatment modalities on function of the salivary glands, larynx and pharynx combine to make hypopharyngeal carcinoma a particularly challenging condition to treat. The impact of diagnosis and treatment on health related QoL is substantial. Read More

J BUON 2019 Jan-Feb;24(1):406-407

1st ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.

J BUON 2019 Jan-Feb;24(1):315-322

Department of Otolaryngology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R.China.

Purpose: This study aimed to investigate the expression pattern of microRNA (miRNA)-195 in laryngeal carcinoma and analyze the relationships of miRNA-195 expression with clinicopathological features and prognosis.

Methods: The expression levels of miRNA-195 in pathological cancer tissue and tumor-adjacent normal tissue of 182 patients with laryngeal carcinoma were measured by reverse transcription-polymerase chain reaction (RT-PCR), and the relationships of relative expression levels of miRNA-195 with clinicopathological features and prognosis of patients with laryngeal carcinoma were analyzed. The invasive ability of cells was measured by Transwell chamber test. Read More

J BUON 2019 Jan-Feb;24(1):1-4

1st ENT Dept, Hippocration Hospital, University of Athens, Athens, Greece.

Caspases (cysteine-aspartic proteases) represent a family of enzymes that modify several functions crucial for cell homeostasis such as inflammation and apoptosis. According to their implication in the apoptotic pathways, caspases are characterized as initiators and executioners, respectively. In the first group have been inserted caspase-2,-8,-9, and -10, whereas caspase-3,-6, and-7 belong to the second category. Read More

Eur J Surg Oncol 2019 Mar 27. Epub 2019 Mar 27.

Department of Head & Neck Surgery, St Luc University Hospital and King Albert II Cancer Institute, Brussels, Belgium; Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium.

Introduction: The aim of this study was to assess the validity of a treatment strategy for T1N0 glottic squamous cell carcinoma.

Methods: One hundred and seventeen patients were prospectively treated according to institutional guidelines. using 1) laser microsurgery (L) for exophytic tumor, limited to one vocal cord, without extension to the anterior commissure or the vocal process of the arytenoid cartilage, 2) radiotherapy (RT) for large or infiltrative tumor reaching the anterior commissure or the vocal process of the arytenoid cartilage, poor endoscopic exposure and cT1b or 3) partial laryngectomy (PL) for tumor infiltrating the anterior commissure. Read More

J Laparoendosc Adv Surg Tech A 2019 Apr 1. Epub 2019 Apr 1.

1 Division of Thyroid Surgery, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, China-Japan Union Hospital of Jilin University, Changchun City, Jilin Province, P. R. China.

Background: The aim of this report was dual: (a) to describe the step-by-step standardized intraoperative percutaneous injection of carbon nanoparticles (CNPs) procedure for CNP-stained central compartment lymph nodes (CLNs) and passive display of parathyroid gland by CNP-stained thyroid in endoscopic thyroidectomy via bilateral areola approach (ETBAA) and (b) evaluation and outcomes of percutaneous injection of CNPs in total thyroidectomy plus CLN dissection through ETBAA.

Materials And Methods: Video describes the technique of intraoperative percutaneous injection of CNPs for central compartment LNs identification, dissection, and parathyroid glands preservation in ETBAA for papillary thyroid cancer.

Results: Supplementary video shows that after intrathyroid injection of CNPs, black carbon can be seen rapidly along the lymphatic vessels to the surrounding LNs. Read More

Cancer Cell Int 2019 20;19:64. Epub 2019 Mar 20.

1Department of Otolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515 China.

Background: Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of LPR is pepsin, which has been shown to induce mucosal inflammation by damaging the mucous membrane. Read More

Mod Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Leukoplakia is a potential precursor of oral as well as laryngeal squamous cell carcinoma. Risk assessment of malignant transformation based on the grade of dysplasia of leukoplakia often does not lead to reliable results. However, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, and leukoplakia express single or multiple members of the melanoma-associated antigens A (MAGE-A) family, while MAGE-A are absent in healthy mucosal tissue. Read More

Auris Nasus Larynx 2019 Mar 28. Epub 2019 Mar 28.

Department of Head and Neck Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.

Lingual lymph node metastases are rarely seen in carcinoma of the tongue, and these nodes are not removed during neck dissection. Lingual lymph nodes are classified into medial and lateral groups, and metastasis to the former is extremely rare. A 55-year-old male with squamous cell carcinoma of the tongue, (stage T4aN0M0), underwent hemiglossectomy with neck dissection and free flap reconstruction. Read More

J Laryngol Otol 2019 Mar 29:1-6. Epub 2019 Mar 29.

Division of Otolaryngology - Head and Neck Surgery,Queen Elizabeth II Health Sciences Centre and Dalhousie University,Halifax,Canada.

Objectives: Transoral laser microsurgery is an increasingly common treatment modality for glottic carcinoma. This study aimed to determine the effect of age, gender, stage and time on voice-related quality of life using the Voice Handicap Index-10.

Methods: Primary early glottic carcinoma patients treated with transoral laser microsurgery were included in the study. Read More

Virol J 2019 03 29;16(1):40. Epub 2019 Mar 29.

WHO WPRO Regional Polio Reference Laboratory and NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Background: Enterovirus C96 (EV-C96) is a newly named type of enterovirus belonging to species C, and the prototype strain (BAN00-10488) was firstly isolated in 2000 from a stool specimen of a patient with acute flaccid paralysis in Bangladesh. In this study, we report the genomic and phenotypic characteristics of two EV-C96 strains isolated from individuals from the Tibet Autonomous Region of China.

Methods: Human rhabdomyosarcoma (RD), human laryngeal epidermoid carcinoma (HEp-2), and human cervical cancer (Hela) cells were infected with the Tibet EV-C96 strains, and enterovirus RNA in the cell culture was detected with a real time RT-PCR-based enterovirus screening method. Read More

Environ Health 2019 03 29;18(1):27. Epub 2019 Mar 29.

Université de Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, Pointe-à-Pitre, France.

Background: Leather dust is an established carcinogen of the sinonasal cavities; however, evidence is lacking regarding its association with other head and neck cancers (HNC). To date, few studies have been conducted on the association between occupational leather dust exposure and the risk of oral, pharyngeal, and laryngeal cancers. The objective of this study was to investigate the association between the risk of HNC and occupational exposure to leather dust. Read More

Ear Nose Throat J 2019 Mar 28:145561319838248. Epub 2019 Mar 28.

1 Department of Otolaryngology and Head Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

Background:: Horner syndrome caused by metastatic squamous cell carcinoma of the head and neck is not common, and when diagnosed, may have serious clinical implications. We aim at highlighting the clinical significance of this finding.

Methods:: We retrospectively reviewed charts of 6 patients with Horner syndrome secondary to metastatic head and neck squamous cell carcinoma (HNSCC) in the neck. Read More

Int J Mol Sci 2019 Mar 26;20(6). Epub 2019 Mar 26.

University of Zurich, Institute of Oral Biology, Plattenstrasse 11, CH-8032 Zurich, Switzerland.

Head and neck squamous cell carcinoma (HNSCC) defines a group of solid tumors originating from the mucosa of the upper aerodigestive tract, pharynx, larynx, mouth, and nasal cavity. It has a metastatic evolution and poor prognosis and is the sixth most common cancer in the world, with 600,000 new cases reported every year. HNSCC heterogeneity and complexity is reflected in a multistep progression, involving crosstalk between several molecular pathways. Read More

Eur Rev Med Pharmacol Sci 2019 Mar;23(5):2062-2068

Department of Otolaryngology, Daqing Oil Field General Hospital, Daqing, China.

Objective: Dysregulation of long non-coding RNAs (lncRNAs) is associated with human carcinogenesis. The aim of the study is to explore the biological functions of MEG3 expression in laryngeal squamous cell carcinoma (LSCC).

Patients And Methods: QRT-PCR analysis was performed to assess the expression of MEG3 in 35 pairs of LSCC tissues and adjacent non-cancerous tissues. Read More

Cancer Biol Ther 2019 Mar 25:1-11. Epub 2019 Mar 25.

a Department of Otolaryngology Head and Neck Surgery , the First Affiliated Hospital of Zhengzhou University , Zhengzhou City , Henan Province , P. R. China.

Laryngeal squamous cell carcinoma (LSCC) accounts for 95% of laryngeal cancer incidence. Tobacco use has been shown to have a linear association with the development of the disease. While early diagnosis and treatment of LSCC are critical in improving the 5-year survival rate and quality of life, diagnosis of early-stage LSCC remains challenging because of the unapparent symptoms. Read More

Indian J Otolaryngol Head Neck Surg 2019 Mar 22;71(1):22-28. Epub 2017 Jul 22.

Department of Otorhinolaryngology, Government Medical College, Kozhikode, Kerala 673008 India.

The successful management of laryngeal and hypopharyngeal cancers requires accurate diagnosis, staging, assessment of patient wishes, and the selection of the most appropriate treatment for the individual patient. Imaging plays an important complementary role to clinical examination and endoscopy in the evaluation of laryngeal and hypopharyngeal cancers. The combined information allows the disease to be staged accurately. Read More

Asian J Surg 2019 Mar 19. Epub 2019 Mar 19.

Department of Surgery, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Robotic thyroidectomy is increasingly used for patients with papillary thyroid carcinoma (PTC). We compared the differences between robotic and endoscopic transaxillary thyroidectomy with regard to surgical procedures.

Methods: This retrospective study enrolled 40 patients with PTC who underwent robotic hemithyroidectomy (robot group) using the Da Vinci S system and 37 patients (endoscopic group) who underwent endoscopic hemithyroidectomy. Read More

Cureus 2019 Jan 8;11(1):e3856. Epub 2019 Jan 8.

Radiation Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, USA.

Purpose: The aim of our study was to report on patterns of failure using detailed information from follow-up positron emission tomography-computed tomography (PET/CT) scans for patients with laryngeal squamous cell carcinoma (SCCA) treated with definitive radiation therapy using intensity-modulated radiation therapy (IMRT).

Methods: One hundred and sixty-eight patients with laryngeal SCCA treated with definitive IMRT using a simultaneous integrated boost were included. The point of recurrence origin on follow-up PET/CT was determined using two separate data-driven methods. Read More

Molecules 2019 Mar 19;24(6). Epub 2019 Mar 19.

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.

Aspernolide A, a butyrolactone secondary metabolite, was purified from the endophytic fungus derived from roots of Decne. In this study, the antitumor activity and mechanisms of aspernolide A on human laryngeal cancer Hep-2 and TU212 cells were studied by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, morphological observation and Western blotting. The results showed that aspernolide A significantly inhibited the proliferation of Hep-2 and TU212 cells in dose- and time-dependent manners. Read More

Am J Otolaryngol 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, 21151 Pomerantz Family Pavilion, 200 Hawkins Drive, 52240, Iowa City, IA, USA.

Merkel cell carcinoma (MCC) is a neuroendocrine cutaneous malignancy that may present as metastatic disease without a known primary site but, most commonly originates in the sun-exposed skin of the head, neck, and extremities. We present a 66-year-old male treated with chemo-radiation for T3N2cM0 laryngeal squamous cell carcinoma (SCCa) six years before he was diagnosed with MCC isolated to the radiated laryngopharynx. Mucosal MCC is rare and radiation-induced MCC has been hypothesized to occur in previously radiated tissue but, never before to the laryngopharynx. Read More

Radiat Oncol 2019 Mar 18;14(1):49. Epub 2019 Mar 18.

Department of Radiation Oncology, Northwestern University, Chicago, IL, USA.

Background: Literature has shown a significant relationship between radiation dose to the larynx and swallowing disorders. We prospectively studied the dose-volume relationship for larynx substructures and aspiration.

Methods: Forty nine patients with stage III/IV head-and-neck (H&N) squamous cell carcinoma were prospectively enrolled in this IRB-approved, federally funded study. Read More

Nanoscale 2019 Mar;11(13):6285-6296

Department of Pharmacy, Shanxi Medical University, Taiyuan 030001, China.

Multimodality therapy under imaging-guidance is significant to improve the accuracy of cancer treatment. In this study, a photoacoustic imaging (PAI)-guided anticancer strategy based on poly-l-lysine functionalized melanin nanoparticles (MNP-PLL) was developed to treat laryngeal squamous cell carcinoma (LSCC). As a promising alternative to traditional therapies for LSCC, MNP-PLL/miRNA nanoparticles were combined with photothermal ablation against primary tumors and miR-145-5p mediated gene therapy for depleting the metastatic potential of tumor cells. Read More

Acta Otolaryngol 2019 Mar 18:1-5. Epub 2019 Mar 18.

a Department of Otorhinolaryngology , The First Affiliated Hospital, Nanjing Medical University , Nanjing , China.

Background: Emerging evidence indicate that inflammation plays a crucial role in carcinogenesis and tumor progression. Inflammatory response biomarkers are recognized as promising prognostic factors in laryngeal squamous cell carcinoma (LSCC).

Objective: To evaluate the prognostic significance of preoperative derived neutrophil-to-lymphocyte ratio (dNLR) in patients with total laryngectomy. Read More