19,177 results match your criteria Laryngeal Carcinoma


Specific growth rates calculated from CTs in patients with head and neck squamous cell carcinoma: a retrospective study performed in Austria.

BMJ Open 2019 Feb 19;9(2):e025359. Epub 2019 Feb 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.

Objective: To provide data on specific growth rates (SGRs) of primary tumours (PT-SGR) and largest pathological cervical lymph nodes (LN-SGR) for head and neck squamous cell carcinoma (HNSCC). To explore PT-SGR's and LN-SGR's correlation with selected biomarkers epidermal growth factor receptor (EGFR), Ki67 and CD44.

Design And Setting: Retrospective study performed at a tertiary oncological referral centre in Innsbruck, Austria. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025359DOI Listing
February 2019

Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre experience.

Radiat Oncol 2019 Feb 19;14(1):34. Epub 2019 Feb 19.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Purpose: Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has become a valuable, potentially curative therapeutic option. Thus, we aimed to determine prognostic factors for survival outcome in order to optimize patient selection for salvage radiotherapy after failure of first-line treatment with surgery alone in this special patient cohort. Read More

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http://dx.doi.org/10.1186/s13014-019-1238-8DOI Listing
February 2019

The Emerging Role of Robotic Surgery among Minimally Invasive Surgical Approaches in the Treatment of Hypopharyngeal Carcinoma: Systematic Review and Meta-Analysis.

J Clin Med 2019 Feb 18;8(2). Epub 2019 Feb 18.

Otorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy.

The aim of this systematic review with meta-analysis was to investigate the available literature on transoral approaches in the treatment of hypopharyngeal squamous cell carcinoma, with a special focus on transoral robotic surgery (TORS). A systematic review was conducted according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) check-list, and 15 studies were included. Five of the included studies evaluated TORS, while ten studies focused on transoral laser microsurgery (TLM) for the treatment of early or advanced stage hypopharyngeal cancer. Read More

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http://dx.doi.org/10.3390/jcm8020256DOI Listing
February 2019

Incidence of second and higher order smoking-related primary cancers following lung cancer: a population-based cohort study.

Thorax 2019 Feb 18. Epub 2019 Feb 18.

Department of Oncology, University of Cambridge, Cambridge, UK.

Background: Lung cancer 5-year survival has doubled over 15 years. Although the risk of second primary cancer is recognised, quantification over time is lacking. We describe the incidence of second and higher order smoking-related primary cancers in lung cancer survivors, identifying high-incidence groups and how incidence changes over time from first diagnosis. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212456DOI Listing
February 2019

Adenoid cystic carcinoma with high-grade transformation forming spindle cell component of the submandibular gland.

Auris Nasus Larynx 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Fukuoka University, School of Medicine, Japan.

Adenoid cystic carcinoma (AdCC) with high-grade transformation (AdCC-HGT) is rare, and AdCC-HGT with spindle cell component is particularly rare. The patient was a 65-year-old man with a 5 cm sized swelling of the right submandibular gland. Submandibular sialoadenectomy was performed. Read More

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http://dx.doi.org/10.1016/j.anl.2019.01.014DOI Listing
February 2019

[Study on the mechanism of miR-497-induced laryngeal squamous cell carcinoma growth inhibition by targeting CDK6].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):126-132

Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital, Tianjin Medical University, Tianjin 300221, China.

To study the effects of miR-497 and CDK6 on the growth of laryngeal squamous cell carcinoma (LSCC). The expressions of CDK6 mRNA in fresh LSCC specimens, the adjacent normal mucosa of LSCC, and cell lines of LSCC were detected with quantitative real time polymerase chain reaction, pcDNA3.1(+) CDK6 plasmids were respectively transfected into the LSCC cells, and MTT assay and clone formation assay were performed to evaluate the growth of LSCC cells. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.006DOI Listing
February 2019

Retrospective analysis of 659 laryngeal squamous cell carcinoma patients treated with open laryngeal function-preserving operations.

Acta Otolaryngol 2018 Nov;138(11):1043-1050

a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.

Background: Open laryngeal function-preserving surgery is a common therapeutic strategy for Chinese laryngeal squamous cell carcinoma (LSCC) patients.

Objectives: To explore the fundamental clinical characteristics and survival prognostic factors of LSCC patients treated with open laryngeal function-preserving operations.

Material And Methods: about a total of 659 LSCC patients undergoing open laryngeal function-preserving operations were retrospectively reviewed. Read More

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http://dx.doi.org/10.1080/00016489.2018.1500711DOI Listing
November 2018

Feasibility and safety of needle-assisted endoscopic thyroidectomy with lateral neck dissection for papillary thyroid carcinoma: a preliminary experience.

Head Neck 2019 Feb 18. Epub 2019 Feb 18.

Department of Thyroid and Vascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Background: Endoscopic thyroidectomy is popular among patients with cosmetic requirements. However, when lateral neck dissection (LND) is required, endoscopic surgery may be challenging. Therefore, we introduced needle-assisted endoscopic technique to achieve endoscopic LND procedure and evaluated its safety and feasibility in the present study. Read More

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http://dx.doi.org/10.1002/hed.25705DOI Listing
February 2019

Transoral flexible laryngoscope biopsy: Safety and accuracy.

World J Otorhinolaryngol Head Neck Surg 2019 Mar 17;5(1):30-33. Epub 2018 Nov 17.

Department of ENT Head & Neck Surgery, Shaheed Mohtarma Benazir Bhutto Medical College & Lyari General Hospital, Karachi, Pakistan.

Objective: To determine the accuracy of transoral flexible laryngoscope (TFL) biopsy and also to identify the safety as office based procedure in terms of complications.

Methods: This is a diagnostic study; the type of intervention is outpatient department based biopsy of laryngeal lesions. All patients seen in ENT outpatient department of Lyari General Hospital with suspicious lesions of Larynx were referred for Transoral Flexible Laryngoscopy Biopsy under local anesthesia. Read More

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http://dx.doi.org/10.1016/j.wjorl.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364665PMC

Radiotherapy in advanced glottic laryngeal carcinoma in a patient with Wegener's granulomatosis: how much radiation dose is needed?

Onco Targets Ther 2019 23;12:753-757. Epub 2019 Jan 23.

Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, Italy,

Wegener's granulomatosis (WG) is an autoimmune disorder characterized by necrotizing granulomas involving mainly the upper-lower respiratory and renal tracts, albeit a potentially life-threatening involvement of other body parts is not rare. Furthermore, there are several reports accounting for an increased risk of solid malignancies due to the autoimmune disease per se, or the immunosuppressive therapies. Among treatments, radiotherapy could be a therapeutic option as proven by its use in typical WG lesions such as solitary granulomas or subglottic stenosis, successfully treated with low radiation dose. Read More

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http://dx.doi.org/10.2147/OTT.S182011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352862PMC
January 2019

Quality of life after total laryngectomy: evaluating the effect of socioeconomic status.

J Laryngol Otol 2019 Feb 18:1-6. Epub 2019 Feb 18.

Division of Otorhinolaryngology, Department of Surgery,University of Cape Town,South Africa.

Objective: Total laryngectomy is considered the primary treatment modality for advanced laryngeal carcinoma. This study assessed the quality of life in patients after total laryngectomy, and ascertained whether quality of life is affected by socioeconomic status.

Method: Forty-seven patients (20 state- and 27 private-sector) who underwent total laryngectomy between 1998 and 2014 responded to the University of Washington Quality of Life Questionnaire, the Voice-Related Quality of Life Questionnaire and the Brief Illness Perception Questionnaire. Read More

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http://dx.doi.org/10.1017/S0022215119000215DOI Listing
February 2019

Surgery versus radiation for T1 glottic carcinoma: Second primary considerations.

Laryngoscope 2019 Feb 15. Epub 2019 Feb 15.

Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, U.S.A.

Although early glottic carcinoma is managed with radiation therapy (RT) or surgery, there is limited data on differences in second primary cancers of the larynx. We utilized the Surveillance, Epidemiology, and End Results (SEER) database to query T1 glottic carcinomas and assess the incidence of second primary laryngeal malignancies. Cumulative hazard for second primary laryngeal malignancies was compared with the log-rank method. Read More

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http://dx.doi.org/10.1002/lary.27854DOI Listing
February 2019

The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx.

Biomed Res Int 2019 15;2019:8142572. Epub 2019 Jan 15.

Department for Otolaryngology and Head and Neck Surgery, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.

The aim of study was to investigate the expression of the proliferation factor Ki-67 and its relationship with histological grade, cancer stage, and treatment outcome in squamous cell carcinoma of the larynx. Samples from 78 patients with laryngeal cancer were analysed retrospectively. Paraffin sections of tumors were immunohistochemically stained for Ki-67 expression. Read More

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http://dx.doi.org/10.1155/2019/8142572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350589PMC
January 2019

Feasibility of transnasal flexible carbon dioxide laser surgery for laryngopharyngeal lesions.

Auris Nasus Larynx 2019 Feb 11. Epub 2019 Feb 11.

Department of Otolaryngology - Head & Neck Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.

Objective: The fiber-guided carbon dioxide (CO) laser is a useful device for laryngopharyngeal surgery. The flexible CO wave-guide laser has been developed and commercially available for several years. However, the transnasal use of CO flexible wave-guided laser surgery through the instrument channel of a flexible endoscope (CO TNFLS) is not permitted in Japan. Read More

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http://dx.doi.org/10.1016/j.anl.2019.01.008DOI Listing
February 2019
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A case report of application of posterior pharyngeal flap in resection and reconstruction of posterior pharyngeal wall carcinomas located at the level of the cricoid cartilage.

Medicine (Baltimore) 2019 Feb;98(7):e14412

Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Rationale: posterior pharyngeal wall carcinomas located at the level of the cricoid cartilage is a rare occurrence. Surgical treatment is a dilemma owing to the retention of laryngeal function PATIENT CONCERNS:: A 56-year-old man underwent a "resection of left cervical tumor" at another hospital. Postoperative pathological report noted a left metastatic squamous cell carcinoma of the neck. Read More

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http://dx.doi.org/10.1097/MD.0000000000014412DOI Listing
February 2019
1 Read

Factors responsible for the development of carbon granuloma post transoral laser cordectomy.

Lasers Med Sci 2019 Feb 13. Epub 2019 Feb 13.

Bombay Hospital Voice and Swallowing Centre, 2nd floor, MRC, Bombay Hospital & Medical Research Centre, 12 New Marine Lines, Mumbai, Maharashtra, 400020, India.

Our study was performed with an aim to analyse the factors responsible for the formation of a carbon granuloma (CG) following transoral laser microlaryngeal cordectomy (TLMC) for early glottic carcinoma. Our study comprises of retrospective data analysis of 78 patients who underwent TLMC for early glottic carcinoma between 2012 and 2017 with the laser settings of an acublade with scanning system, size 1-2 mm, depth 1-3 (250-750 μm), power 10 watts in a repeat mode with time off 0.25 s. Read More

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http://dx.doi.org/10.1007/s10103-019-02726-3DOI Listing
February 2019

Robotic transoral thyroidectomy: Total thyroidectomy and ipsilateral central neck dissection with da Vinci Xi Surgical System.

Head Neck 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Background: Transoral approach for thyroidectomy draws attention recently among the thyroid surgeons, with the merits of cosmetic outcomes and minimal flap dissection. The aim of this study is to demonstrate the details and the steps of transoral robotic thyroidectomy.

Methods: We made three incisions in the gingival-buccal sulcus for three 8-mm intraoral ports: one inverted U-shaped 1-cm midline incision approximately 2 cm above the frenulum, and two 0. Read More

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http://dx.doi.org/10.1002/hed.25661DOI Listing
February 2019

Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation.

Laryngoscope 2019 Feb 12. Epub 2019 Feb 12.

Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.

Objectives: We aim to report oncologic outcomes after conventional radiotherapy (ConRT) using opposed lateral beams and intensity-modulated radiation therapy (IMRT) for tumor (T)1 nodal (N)0 T1 N0 glottic squamous cell carcinoma.

Study Design: Retrospective case-control study.

Methods: We retrospectively reviewed demographic, disease, and treatment characteristics for patients treated at our institution during 2000 to 2013. Read More

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http://dx.doi.org/10.1002/lary.27873DOI Listing
February 2019

The impact of reducing alcohol consumption in Australia: an estimate of the proportion of potentially avoidable cancers 2013-2037.

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.

The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. Read More

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http://dx.doi.org/10.1002/ijc.32204DOI Listing
February 2019
2 Reads

Radiation therapy treatment facility and overall survival in the adjuvant setting for locally advanced head and neck squamous cell carcinoma.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut.

Background: Treatment at high-volume surgical facilities (HVSFs) provides a survival benefit for patients with head and neck squamous cell carcinomas (HNSCCs); however, it is unknown what role postoperative radiation therapy (PORT) plays in achieving the improved outcomes.

Methods: From the National Cancer Database, 6844 patients with locally advanced invasive HNSCCs of the oral cavity, oropharynx, larynx, and hypopharynx who underwent definitive surgery with PORT between 2004 and 2013 were identified. HVSFs were those in the top percentile for annual case volume during this period. Read More

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http://dx.doi.org/10.1002/cncr.32001DOI Listing
February 2019

Probe-based confocal laser endomicroscopy in detecting malignant lesions of vocal folds.

Acta Otorhinolaryngol Ital 2019 Jan 31. Epub 2019 Jan 31.

Department of Otorhinolaryngology, Head and Neck Surgery, Universität Regensburg, University Hospital, Regensburg, Germany.

Probe-based confocal laser endomicroscopy (CLE) is an innovative technique for real-time, non-invasive analysis of the surface epithelium. While being successfully used for diagnosis by experts, this method has not yet been established in clinical routine, partly due to the lack of standards and criteria for classifying various lesions. Our aim was to determine the diagnostic value and inter-rater reliability of CLE in detecting malignant lesions of the vocal cords. Read More

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http://dx.doi.org/10.14639/0392-100X-2121DOI Listing
January 2019

New knowledge about old drugs; a cardenolide type glycoside with cytotoxic effect and unusual secondary metabolites from Digitalis grandiflora Miller.

Fitoterapia 2019 Feb 6;134:73-80. Epub 2019 Feb 6.

Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100, Sihhiye, Ankara, Turkey.

Phytochemical investigation of the aerial parts of Digitalis grandiflora Miller (Plantaginaceae) led to the isolation of an undescribed cardenolide type glycoside digigrandifloroside (1) along with five known compounds, rengyoside A (2), rengyoside B (3), cleroindicin A (4), salidroside (5), and cornoside (6), from its aqueous fraction of methanolic extract. Structures of the isolated compounds were determined by means of spectroscopic techniques. 1-6 were isolated for the first time from D. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.001DOI Listing
February 2019

Oncological outcomes of surgical treatment for T3 supraglottic laryngeal squamous cell carcinoma patients.

Acta Otolaryngol 2018 Nov 8;138(11):1028-1034. Epub 2019 Feb 8.

a Department of Otorhinolaryngology , Fudan University, Eye Ear Nose and Throat Hospital , Shanghai , China.

Background: T3 supraglottic laryngeal carcinoma (LC) is a common advanced laryngeal cancer.

Objective: This study was conducted to assess the clinical results of pathological T3 (pT3) supraglottic LC patients who were amenable to laryngectomy treated with primary surgery and postoperative therapy.

Methods: Retrospective review of 202 pT3 cases of supraglottic laryngeal squamous cell carcinoma. Read More

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http://dx.doi.org/10.1080/00016489.2018.1490031DOI Listing
November 2018

DIAPH1 Is Upregulated and Inhibits Cell Apoptosis through ATR/p53/Caspase-3 Signaling Pathway in Laryngeal Squamous Cell Carcinoma.

Dis Markers 2019 14;2019:6716472. Epub 2019 Jan 14.

Department of Otorhinolaryngology-Head and Neck Surgery, The Third People's Hospital, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.

Cancer bioinformatics has been used to screen possible key cancer genes and pathways. Here, through bioinformatics analysis, we found that high expression of diaphanous related formin 1 (DIAPH1) was associated with poor overall survival in head and neck squamous cell carcinoma and laryngeal squamous cell carcinoma (LSCC). The effect of DIAPH1 in LSCC has not been previously investigated. Read More

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http://dx.doi.org/10.1155/2019/6716472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348834PMC
January 2019

Long-term oncological and functional outcomes of induction chemotherapy followed by (chemo)radiotherapy vs definitive chemoradiotherapy vs surgery-based therapy in locally advanced stage III/IV hypopharyngeal cancer: Multicenter review of 266 cases.

Oral Oncol 2019 Feb 27;89:84-94. Epub 2018 Dec 27.

Department of Otorhinolaryngology-Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University, College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: The aim of this study was to evaluate the treatment outcomes for stage III/IV locally advanced hypopharyngeal squamous cell carcinoma (SCC), comparing induction chemotherapy followed by (chemo)radiotherapy (ICT), definitive chemoradiotherapy (CRT) and surgery-based therapy (SRT).

Subjects And Methods: Two hundred sixty-six patients with stage III/IV locally advanced hypopharyngeal squamous cell carcinoma (SCC) who underwent ICT (n = 74), CRT (n = 53) or SRT (n = 139) from 1997 through 2014 at the Seoul National University Hospital (n = 127) and the Hallym University Medical Center (n = 139) were enrolled in the study. All surgical procedures in the SRT group were performed by a single surgeon to eliminate surgeon bias. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.015DOI Listing
February 2019
3.607 Impact Factor

Free posterior tibial artery perforator flap for 2-stage tracheal reconstruction in patients after resection of well-differentiated thyroid carcinoma invading the trachea.

Head Neck 2019 Feb 6. Epub 2019 Feb 6.

Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: The present study was conducted to explore the efficacy of using a free posterior tibial artery perforator flap (FPTAPF) for trachea reconstruction after resection of well-differentiated thyroid carcinoma (WDTC) invading the trachea.

Methods: We retrospectively collected and analyzed clinical and surgical data from 14 patients who underwent tracheal reconstruction using a FPTAPF after resection of WDTC invading the trachea between August 2014 and July 2017.

Results: Satisfactory tracheal structure and functional recovery were obtained in 11 of the 14 patients. Read More

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http://dx.doi.org/10.1002/hed.25675DOI Listing
February 2019
2 Reads
2.641 Impact Factor

The role of organ- and function-preserving radiotherapy in the treatment of adenoid cystic carcinoma of the larynx.

Head Neck 2019 Feb 5. Epub 2019 Feb 5.

Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.

Background: To evaluate clinical outcome and functional larynx preservation after radiotherapy (RT) for adenoid cystic carcinoma (ACC) of the larynx.

Methods: Eleven patients with primary ACC of the larynx, who received RT definitely (n = 5/11) or postoperatively (n = 6/11), were analyzed regarding survival and treatment-related toxicity with the focus on functional larynx preservation.

Results: Median follow-up was 45 months. Read More

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http://dx.doi.org/10.1002/hed.25678DOI Listing
February 2019
1 Read

A Multicenter Phase II Trial of Docetaxel, Cisplatin, and Cetuximab (TPEx) Followed by Cetuximab and Concurrent Radiotherapy for Patients With Local Advanced Squamous Cell Carcinoma of the Head and Neck (CSPOR HN01: ECRIPS Study).

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Induction chemotherapy (IC) is a treatment option for locally advanced squamous cell carcinoma of the head and neck (LA SCCHN). However, treatment with docetaxel, cisplatin, and 5-FU (TPF) followed by cisplatin and radiotherapy is controversial because of toxicity concerns. The aim of this phase II study was to assess the feasibility of docetaxel, cisplatin, and cetuximab (TPEx) followed by cetuximab and concurrent radiotherapy for LA SCCHN. Read More

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http://dx.doi.org/10.3389/fonc.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349830PMC
January 2019
1 Read

Expression of protein disulfide isomerase A3 and its clinicopathological association in gastric cancer.

Oncol Rep 2019 Feb 5. Epub 2019 Feb 5.

Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo 113-8602, Japan.

Protein disulfide isomerase A3 (PDIA3) is a chaperone protein that supports the folding and processing of synthesized proteins. Its expression is associated with the prognosis of laryngeal cancer, hepatocellular carcinoma, diffuse glioma and uterine cervical cancer. In the present study, the expression levels of PDIA3 and its clinicopathological association were examined in 52 cases of gastric cancer (GC). Read More

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http://dx.doi.org/10.3892/or.2019.6999DOI Listing
February 2019
1 Read

Pretreatment albumin globulin ratio has a superior prognostic value in laryngeal squamous cell carcinoma patients: a comparison study.

J Cancer 2019 1;10(3):594-601. Epub 2019 Jan 1.

Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Many inflammation-based markers have been reported their prognostic significance. Current study was designed to explore the prognostic value of albumin/globulin ratio (AGR), along with other inflammation-based markers, including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and lymphocyte/monocyte ratio (LMR) in laryngeal squamous cell carcinoma (LSCC) patients. This study was a retrospective analysis of the data related to 232 newly diagnosed LSCC patients. Read More

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http://dx.doi.org/10.7150/jca.28817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360422PMC
January 2019

Basaloid Squamous Cell Carcinoma of the Larynx: A National Cancer Database Analysis.

Otolaryngol Head Neck Surg 2019 Feb 5:194599818816299. Epub 2019 Feb 5.

1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Saint Louis University, Saint Louis, Missouri, USA.

Objective: Basaloid squamous cell histology is a rare variant that accounts for about 2% of all head and neck squamous cell laryngeal carcinomas. The purpose of this study was to examine overall survival rates of patients according to treatment, stage, and laryngeal subsite.

Study Design: Retrospective analysis. Read More

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http://dx.doi.org/10.1177/0194599818816299DOI Listing
February 2019

[Epigenetic regulations in laryngeal squamous cell carcinoma].

Authors:
W X Meng B S Wang

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;32(22):1958-1762

Laryngeal cancer, which is mainly consisted of laryngeal squamous cell carcinoma(LSCC), is one of the common neoplasms in head and neck. In spite the advantages in diagnose and treatment, the mortality of LSCC is still high in the past 20 years. Epigenetic regulations play a important role in LSCC. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.22.019DOI Listing
November 2018

MMP2/3 promote the growth and migration of laryngeal squamous cell carcinoma via PI3K/Akt-NF-κB-mediated epithelial-mesenchymal transformation.

J Cell Physiol 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiation Oncology, Eye and ENT Hospital, Fudan University, Shanghai, China.

Laryngeal squamous cell carcinoma (LSCC) is an aggressive malignancy with metastatic potential and high mortality worldwide. Matrix metalloproteinases (MMPs) are a group of extracellular proteolytic enzymes. Although MMPs have been proved to be essential in the process of tumor migration and metastasis in most types of carcinomas, the expression and function of MMP2/3 in LSCC remain unknown. Read More

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http://dx.doi.org/10.1002/jcp.28242DOI Listing
February 2019

Presentation of second primary cancers in young laryngeal carcinoma patients.

Acta Otolaryngol 2019 Feb 3:1-5. Epub 2019 Feb 3.

a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

Background: Laryngeal squamous cell carcinoma (LSCC) is rare in the young.

Objectives: We characterized the clinical behavior of LSCC and assessed the presentation of second primary tumors (SPCs) in this patient population.

Materials And Methods: Data from the Finnish Cancer Registry (FCR) were used to identify an epidemiological series of LSCC patients diagnosed at the age of 40 years or under, during 1953-2012 in Finland. Read More

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http://dx.doi.org/10.1080/00016489.2018.1527037DOI Listing
February 2019

A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities.

J Inorg Biochem 2019 Jan 28;193:130-132. Epub 2019 Jan 28.

Institute of POM-based Materials, Hubei Provincial Key Laboratory of Green Materials for Light Industry, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Sino-German Biomedical Center, Hubei University of Technology, Wuhan 430068, China. Electronic address:

A new strategy to construct polyoxovanadate hybrids incorporating amino acid esters in mild conditions was presented in this paper. These new hybrids were not only structurally determined by Single Crystal X-Ray diffraction, but also exhibited higher antitumor activities against laryngeal carcinoma, rhabdomyoma, and breast adenocarcinoma tumor cells compared with the traditional commercial medicine 5-fluorouracil. These results would provide a promising lead scaffold for further design and synthesis of potential anticancer agents. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.013DOI Listing
January 2019
3.444 Impact Factor

Tumor budding in laryngeal carcinoma.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):7-10

Department of Head and Neck Surgery, Health Sciences University, Tepecik Training and Research Hospital, Izmir, Turkey.

Background: Tumor budding was defined as a single cancer cell or a cluster of fewer than five cancer cells in the stroma of the invasive tumor margin. It has been suggested as a prognostic factor in various cancers, such as esophageal, lung, colorectal, and endometrial. There are only a few studies about the prognostic signifi cance of tumor budding in laryngeal carcinomas. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_428_17DOI Listing
February 2019

Aurora kinase A induces chemotherapy resistance through revival of dormant cells in laryngeal squamous cell carcinoma.

Head Neck 2019 Feb 1. Epub 2019 Feb 1.

Department of Otolaryngology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Chemotherapy resistance was an important tumor metastasis mechanism.

Methods: Cell Counting Kit-8 assay and plate colony formation assay were applied to examine the proliferation of laryngeal squamous cell carcinoma (LSCC). Immunofluorescent staining and Western blotting were carried out to show the expression of related proteins. Read More

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http://dx.doi.org/10.1002/hed.25689DOI Listing
February 2019
2.641 Impact Factor

Ten-year outcome of curative "exclusive" chemotherapy in N0M0 squamous cell carcinoma of the larynx and pharynx with complete clinical response.

Head Neck 2019 Feb 1. Epub 2019 Feb 1.

Department of Otorhinolaryngology - Head and Neck Surgery, Université Paris Descartes Sorbonne Paris Cité, Hôpital Européen Georges Pompidou, Paris, France.

Background: The aim of our study was to document 10-year outcome after curative "exclusive" chemotherapy in N0M0 squamous cell carcinoma of the larynx and pharynx.

Methods: Retrospective nonrandomized analysis of an inception cohort of 191 patients. Platinum salt and 5-fluorouracil were used in all patients. Read More

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http://dx.doi.org/10.1002/hed.25674DOI Listing
February 2019

Collision carcinoma of squamous cell carcinoma and small cell neuroendocrine carcinoma of the larynx: A case report and review of the literature.

World J Clin Cases 2019 Jan;7(2):242-252

Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Background: Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma (SCC) and neuroendocrine carcinoma (NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and treatment.

Case Summary: A 61-year-old man presented with a 1-year history of hoarseness. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i2.242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354099PMC
January 2019

Oxidative Response and Micronucleus Centromere Assay in HEp-2 Cells Exposed to Fungicide Iprodione.

Chem Res Toxicol 2019 Feb 14. Epub 2019 Feb 14.

GIBE (Grupo de Investigación en Biología Evolutiva), FCEyN-UBA, Facultad de Ciencias Exactas y Naturales, Instituto de Ecología, Genética y Evolución de Buenos Aires - Consejo de Investigaciones Científicas y Técnicas) , Universidad de Buenos Aires (IEGEBA-CONICET) , Ciudad Universitaria, Pabellón II, 4° Piso Laboratories. 43-46 , C1428EGA Buenos Aires , Argentina.

The fungicide agents are a key component in the fruits and vegetables production. The Iprodione residues are one of the pesticide more frequently found in food products. The available data about the cytotoxicity of iprodione and its metabolites are scarce and do not allow characterization of its genotoxic potential and define the risk assessment. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.8b00405DOI Listing
February 2019
1 Read

Randomized controlled single-blinded clinical trial of functional voice outcome after vascular targeting KTP laser microsurgery of early laryngeal cancer.

Head Neck 2019 Jan 31. Epub 2019 Jan 31.

Department of Otorhinolaryngology-Section of Phoniatrics, Ludwig-Maximilians-University Medical Center, Munich, Germany.

Background: Local control rate (LCR) of early glottic cancer is high after radiation therapy or transoral laser microsurgery (TLM). The aim of this study was to investigate functional voice outcome after TLM using a microvessel-ablative potassium-titanyl-phosphate (KTP) laser in comparison with a gold standard cutting CO laser.

Methods: The primary end point of this prospective, randomized, single-blinded, clinical phase II study with control group was voice outcome during a follow-up of 6 months assayed by Voice Handicap Index (VHI-30)-questionnaires in patients with unilateral high-grade dysplasia, carcinoma in situ or early glottic cancer undergoing TLM-KTP (n = 8) or TLM-CO (n = 12). Read More

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http://dx.doi.org/10.1002/hed.25474DOI Listing
January 2019

Evaluation of microRNA expression profiling in highly metastatic laryngocarcinoma cells.

Acta Otolaryngol 2018 Dec 31;138(12):1105-1111. Epub 2019 Jan 31.

f Otolaryngology Head and Neck Surgery , Chinese PLA General Hospital , Beijing , China.

Background: Until now, little is known about the role of miRNAs in the invasion and metastasis of Laryngeal squamous cell carcinoma (LSCC).

Objectives: This study aimed to explore the relationship between microRNA and the invasion and metastasis of LSCC.

Material And Methods: The highly metastatic laryngocarcinoma cells were obtained from the established animal model with spontaneous lymph node metastasis of LSCC in our previous study. Read More

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http://dx.doi.org/10.1080/00016489.2018.1508887DOI Listing
December 2018
0.990 Impact Factor

Oncologic and functional outcomes of salvage supracricoid partial laryngectomy.

Acta Otolaryngol 2018 Dec 31;138(12):1117-1122. Epub 2019 Jan 31.

c Department of Otorhinolaryngology , Yonsei University College of Medicine , Seodaemun-gu , Seoul , Korea.

Background: Supracricoid partial laryngectomy (SCL) can have a positive impact on patients' quality of life by circumventing dysphagia and voice problems resulting from creation of a permanent stoma after conventional total laryngectomy (TL) surgery.

Aims/objectives: The aim of this study was to investigate the oncologic and functional outcomes of salvage SCL for recurrent laryngeal carcinoma.

Material And Methods: Forty-five patients that underwent salvage surgery for recurrent laryngeal carcinoma between January 2004 and May 2015 after initial treatment failure were included in this retrospective study. Read More

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http://dx.doi.org/10.1080/00016489.2018.1506154DOI Listing
December 2018

Association Between Cancer Incidence and Mortality in Web-Based Data in China: Infodemiology Study.

J Med Internet Res 2019 Jan 29;21(1):e10677. Epub 2019 Jan 29.

School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Cancer poses a serious threat to the health of Chinese people, resulting in a major challenge for public health work. Today, people can obtain relevant information from not only medical workers in hospitals, but also the internet in any place in real-time. Search behaviors can reflect a population's awareness of cancer from a completely new perspective, which could be driven by the underlying cancer epidemiology. Read More

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http://dx.doi.org/10.2196/10677DOI Listing
January 2019
2 Reads
3.428 Impact Factor

Role of narrow band imaging in the diagnosis of laryngeal lesions: Pilot study from India.

Indian J Cancer 2018 Jul-Sep;55(3):242-247

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Narrow band imaging (NBI) is a new imaging technique developed to improve the diagnostic accuracy of head and neck cancers by depiction of tumor-specific neo-angiogenesis. The purpose of this study was to assess the value of NBI in the diagnosis of laryngeal lesions.

Aim: To assess the sensitivity and specificity of combined white light endoscopy (WLE) and NBI compared with WLE alone in the diagnosis of laryngeal lesions. Read More

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http://dx.doi.org/10.4103/ijc.IJC_590_17DOI Listing
January 2019
1 Read

The prognostic value of tumor depth for cervical lymph node metastasis in hypopharyngeal and supraglottic carcinomas.

Head Neck 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: To analyze the prognostic value of the clinicopathological parameters of primary lesions for predicting cervical lymph node metastasis in patients with hypopharyngeal and/or supraglottic carcinoma.

Methods: We enrolled 127 patients with squamous cell carcinomas originating in the hypopharyngeal and/or supraglottic regions.

Results: Multivariate analysis identified the tumor depth as an independent predictive factor for lymph node metastasis (odds ratio, 4. Read More

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http://dx.doi.org/10.1002/hed.25667DOI Listing
January 2019
1 Read

Ultrasonography guided fine needle aspiration cytology in patients with laryngo-hypopharyngeal lesions.

Braz J Otorhinolaryngol 2018 Dec 28. Epub 2018 Dec 28.

All India Institute Of Medical sciences, Department of Otorhinolaryngology, New Delhi, India.

Introduction: Laryngeal lesions are usually evaluated by microlaryngoscopy/direct laryngoscopy under anaesthesia for disease mapping and tissue diagnosis. However patients with anticipated airway compromise due to laryngeal mass may require either a protective tracheotomy or emergency tracheotomy to secure the airway. To minimise risk of unplanned tracheotomy and expedite the diagnosis we performed ultrasound-guided transcutaneous fine needle aspiration cytology. Read More

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http://dx.doi.org/10.1016/j.bjorl.2018.11.005DOI Listing
December 2018
1 Read

Aberrant methylation and downregulation of ZNF667-AS1 and ZNF667 promote the malignant progression of laryngeal squamous cell carcinoma.

J Biomed Sci 2019 Jan 26;26(1):13. Epub 2019 Jan 26.

Department of Otorhinolaryngology, The Second Hospital of Hebei Medical University, 215 Heping West Road, Shijiazhuang, 050000, Hebei, China.

Background: Dysregulated long noncoding RNAs (lncRNAs) are involved in the development of tumor. Aberrant methylation is one of the most frequent epigenetic alterations that regulate the expression of genes. The aim of this study was to determine the expression and methylation status of ZNF667-AS1 and ZNF667, elucidate their biological function in the development of LSCC, and identify a cis-regulation of ZNF667-AS1 to ZNF667. Read More

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http://dx.doi.org/10.1186/s12929-019-0506-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347788PMC
January 2019