92,941 results match your criteria Laryngeal Carcinoma


Laryngeal hereditary hemorrhagic telangiectasia.

Ear Nose Throat J 2018 Dec;97(12):388

Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language Sciences and Technology, University of Mons, Mons, Belgium.

View Article
December 2018

Assessment of the Safety of the New Hybrid Pencil Type Energy (NP) Device Used Close to the Recurrent Laryngeal Nerve in a Porcine Model: Comparison With a Conventional Electrosurgical Knife.

Surg Innov 2018 Dec 12:1553350618817646. Epub 2018 Dec 12.

1 Keio University, School of Medicine Tokyo, Japan.

Background: Recurrent laryngeal nerve (RLN) paralysis is mainly associated with esophagectomy, and it may result in not only other morbidities, such as aspiration pneumonia, but also in long-term issues. Therefore, an approach to prevent RLN paralysis is necessary. The present study was designed to determine the technical usability of the new hybrid pencil type energy (NP) device developed by Olympus Corporation (Tokyo, Japan) and compare it with a conventional electrosurgical knife (EK) for resection around the RLN lymph nodes. Read More

View Article
December 2018

Detection of Autoantibodies by Indirect Immunofluorescence Cytochemistry on Hep-2 Cells.

Methods Mol Biol 2019 ;1901:19-46

Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Indirect immunofluorescence assay (IFA) has been used for detection of autoantibodies against cellular antigens for more than 50 years. Originally using rodent tissue as substrate, the method was optimized by using the human immortal HEp-2 cell line derived from a larynx epidermal carcinoma. The HEp-2/IFA platform allows for optimal visualization of several cellular domains recognized by autoantibodies in the samples being tested. Read More

View Article
January 2019

Transoral Robotic Thyroidectomy for Papillary Thyroid Carcinoma: Perioperative Outcomes of 100 Consecutive Patients.

World J Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Background: Endoscopic transoral thyroidectomy is a recently introduced technique of remote access thyroidectomy. We previously reported the feasibility of the robotic approach (TORT). Nevertheless, experience to date is limited, with scant data on outcomes in patients with papillary thyroid carcinoma (PTC). Read More

View Article
December 2018
2 Reads

Nasal function and CPAP compliance.

Auris Nasus Larynx 2018 Dec 8. Epub 2018 Dec 8.

Department of Otorhinolaryngology, Toho University Graduate School of Medicine, Japan; Department of Otorhinolaryngology, Toho University Omori Medical Center, Japan. Electronic address:

Objective: Continuous positive airway pressure (CPAP) is the mainstay therapy for patients with obstructive sleep apnea (OSA) however compliance with CPAP is variable. Nasal ailments, such as nasal congestion are frequently mentioned as a cause for CPAP non-compliance, and potentially could be addressed prior to CPAP initiation, however, no specific criteria or recommendations for the evaluation and management of these patients exist. The aim of this retrospective study is to evaluate the effects of nasal anatomic features and disease on adherence to CPAP therapy for patients with OSA and determine the indications for pre-CPAP nasal treatment by using data obtained at clinical examination. Read More

View Article
December 2018

Reversal of hoarseness with recognition of Ortner syndrome in a patient with severe mitral regurgitation.

J Cardiol Cases 2013 Feb 8;7(2):e48-e50. Epub 2012 Dec 8.

Department of Second Section of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fuxing Street, Guishan Township, Taoyuan County 33305, Taiwan.

Loss of voice due to vocal cord paralysis, as in Ortner syndrome, is secondary to left recurrent laryngeal nerve palsy. Cardiovascular cause should be listed as a differential diagnosis of hoarseness and is incumbent upon the diagnostic physician to be familiar with the condition. A 56-year-old male presented to our emergency department with shortness of breath due to severe mitral regurgitation. Read More

View Article
February 2013

EA promotes swallowing via activating swallowing-related motor neurons in the Nucleus Ambiguus.

Brain Res 2018 Dec 8. Epub 2018 Dec 8.

Guangzhou University of Chinese Medicine, No.232 Waihuan East Road, Panyu District Guangzhou, Guangdong province, 510006,China. Electronic address:

To observe the effect of electroacupuncture (EA) on swallowing and its underlying mechanism, 32 Sprague-Dawley (SD) rats were chose and the electrophysiology was used to detect the discharge of nucleus ambiguus (NA) after EA at CV23 (Lianquan), GV16 (Fengfu), and other acupoints. The swallowing-related motor neuron was identified by antidromic stimulation through recurrent laryngeal nerve. Meanwhile, the swallowing numbers were induced by Double-distilled water (DDW) and the neuron discharges were recorded before and after EA. Read More

View Article
December 2018
2 Reads

Post-diagnosis aspirin use and survival in veterans with head and neck cancer.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia.

Background: Our objective was to determine the effect of post-diagnosis aspirin use on survival in veterans with head and neck squamous cell carcinoma.

Methods: Retrospective cohort study of 584 veterans with head and neck squamous cell carcinoma treated at the Washington DC VA Medical Center between 1995 and 2015. Charts were queried for clinical-pathologic data, aspirin prescriptions, and outcome. Read More

View Article
December 2018
1 Read

Increased risk of postoperative complications after total thyroidectomy with Graves' disease.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Ewha Womans University Medical Center, Seoul, South Korea.

Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear.

Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group).

Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Read More

View Article
December 2018

Laryngeal mask airway versus endotracheal tube for percutaneous dilatational tracheostomy in critically ill adults.

Cochrane Database Syst Rev 2018 Nov 15;11:CD009901. Epub 2018 Nov 15.

Wiesbaden Business School, RheinMain University of Applied Science, Bleichstr. 44, Wiesbaden, Germany, 65183.

Background: Percutaneous dilatational tracheostomy (PDT) is one of the most common bedside surgical procedures performed in critically ill adults, on intensive care units (ICUs), who require long-term ventilation. PDT is associated with relevant life-threatening complications: Cuff rupture or accidental extubation may lead to hypoxia, aspiration or loss of airway. Puncture of the oesophagus, or creating a false passage during dilatation or replacement of the tracheostomy tube, can lead to pneumothorax or emphysema. Read More

View Article
November 2018
1 Read

Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A.

Objectives/hypothesis: The authors used the Surveillance, Epidemiology, and End Results (SEER) database to analyze epidemiological features of patients presenting with supraglottic squamous cell carcinoma (SCCa) and to evaluate treatment trends and outcomes.

Methods: The SEER database was queried for patients with supraglottic SCCa from 1973 to 2013. Information on demographics; tumor size; histologic grade; American Joint Committee on Cancer (AJCC) stage; SEER local, regional, distant stage; and treatment modality were analyzed. Read More

View Article
December 2018
1 Read

Sclerosis of the arytenoid cartilage and glottic carcinoma: A clinical-pathological study.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Otolaryngology Unit, Vittorio Veneto Hospital, Treviso, Italy.

Background: Given the relevance of any tumor invasion of the arytenoid cartilage or crico-arytenoid unit to the planning open partial horizontal laryngectomy (OPHL) for laryngeal squamous cell carcinoma (LSCC), it is important to have a reliable radiological test to assess impairments of these structures.

Methods: We retrospectively compared the endoscopic, radiological, and pathological findings in patients with glottic LSCC who underwent OPHL.

Results: The endoscopic finding of a reduced (impaired or absent) vocal cord motility proved more sensitive, with better positive and negative predictive values, but less specific than the radiological finding of complete arytenoid sclerosis in detecting histologically assessable infiltration of the arytenoid cartilage. Read More

View Article
December 2018
1 Read

AHNS series: Do you know your guidelines? Guideline recommendations for recurrent and persistent head and neck cancer after primary treatment.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Otolaryngology - Head & Neck Surgery, Division of Head & Neck Oncology, University of Toronto, Sunnybrook Health Sciences and the Odette Cancer Centre, Michael Garron Hospital, Toronto, Ontario, Canada.

Locoregional recurrent/persistent head and neck cancer following primary treatment is a significant challenge as it is usually difficult to treat and has worse outcomes compared to the primary setting. Surgical resection of a local or regional recurrence offers the best chance of cure when feasible. Local recurrence outcomes vary by subsite with laryngeal recurrences having the best prognoses and hypopharynx having the worst. Read More

View Article
December 2018

Venous thromboembolism in head and neck surgery: Risk, outcome, and burden at the national level.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Venous thromboembolism (VTE) can complicate major surgeries. This study examines the risk and outcomes of VTE in patients who underwent head and neck surgeries.

Methods: Retrospective cross-sectional analysis utilizing the Nationwide Readmissions Database (2010-2014). Read More

View Article
December 2018
1 Read

Laryngeal temperature simulations during carbon dioxide laser irradiation delivered by a scanning micromanipulator.

Lasers Med Sci 2018 Dec 7. Epub 2018 Dec 7.

Department. of Otolaryngology, Vanderbilt University Medical Center, 1215 21st Ave S., Nashville, TN, 37232, USA.

We use scatter-limited phototherapy techniques to calculate the time-dependent temperature profiles of incisions made with a commercial carbon dioxide laser being used to make a 1-mm incision under computer control using the Digital Acublade™ and with incisions made with the same laser under manual control. The goal is to understand the differences in the amount of lateral thermal damage that is likely from the computer-controlled incisions versus the manually controlled incisions. The temperature profiles are calculated from the absorption and scatter of light in a homogeneous material. Read More

View Article
December 2018

Central compartment revision surgery for persistent or recurrent thyroid carcinoma: analysis of survival and complication rate.

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Largo del Pozzo, 71, 41125, Modena, Italy.

Purpose: Locoregional recurrence of thyroid carcinoma is relatively common and reported rate are between 5 and 20%. Cervical nodes are usually involved, especially at the central compartment. The management of recurrent thyroid carcinoma at central compartment still remains challenging because of higher incidence of complication rate. Read More

View Article
December 2018

MicroRNA‑98/PTEN/AKT pathway inhibits cell proliferation and malignant progression of hypopharyngeal carcinoma by MTDH.

Oncol Rep 2018 Dec 6. Epub 2018 Dec 6.

Department of Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Laryngeal carcinoma is one of the most common tumors concerning otorhinolaryngology head and neck surgery, however, the pathogenesis of laryngeal carcinoma remains unclear. MicroRNAs (miRNAs) have been reported to play vital roles in the pathogenesis of laryngeal carcinoma Herein, the present study was designed to explore the function and mechanism of miRNA‑98 in hypopharyngeal carcinoma. In brief, qRT‑PCR, MTT assay, western blot analysis, Transwell assay and luciferase reporter assay were performed. Read More

View Article
December 2018

MicroRNA‑143‑3p suppresses cell growth and invasion in laryngeal squamous cell carcinoma via targeting the k‑Ras/Raf/MEK/ERK signaling pathway.

Authors:
Feng Zhang Hua Cao

Int J Oncol 2018 Dec 6. Epub 2018 Dec 6.

Ear Nose and Throat Hospital, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

MicroRNAs (miRNAs or miRs) have been identified as an important regulator in carcinogenesis and other pathological processes. However, the molecular mechanism underlying the function of miRNAs in the progression and development of laryngeal squamous cell carcinoma (LSCC) remains to be fully elucidated. In the present study, the miRNA expression pattern in LSCC tissues was profiled using miRNA microarray analysis. Read More

View Article
December 2018

Comparison Between Lidocaine Inhalation and Intravenous Dexamethasone in Reducing Postoperative Sore Throat Frequency After Laryngeal Mask Insertion.

Anesth Pain Med 2018 Oct 25;8(5):e82131. Epub 2018 Aug 25.

Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia.

Background: The frequency of postoperative sore throat (POST) after laryngeal mask airway insertion (LMA) was relatively high. Lidocaine might reduce the pain and inflammatory response. Additionally, inhalation form might result in a better distribution, which results in a better airway analgesia and minimal systemic effect. Read More

View Article
October 2018

A Large Substernal Goiter that Extended to Both Sides of the Thorax.

Case Rep Surg 2018 5;2018:6107982. Epub 2018 Nov 5.

Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.

Most substernal goiters can be managed through the transcervical approach, but a sternotomy is required in some cases. This report is about a large substernal goiter, which was resected via a transcervical and full sternotomy approach. The patient was a 57-year-old female, who visited our hospital for surgical treatment for a large substernal goiter. Read More

View Article
November 2018

Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia.

PLoS One 2018 11;13(12):e0208938. Epub 2018 Dec 11.

Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

In nerve regeneration studies, various animal models are used to assess nerve regeneration. However, because of the difficulties in functional nerve assessment, a visceral nerve injury model is yet to be established. The superior laryngeal nerve (SLN) plays an essential role in swallowing. Read More

View Article
December 2018

A comparative evaluation of ProSeal laryngeal mask airway, I-gel and Supreme laryngeal mask airway in adult patients undergoing elective surgery: A randomised trial.

Indian J Anaesth 2018 Nov;62(11):858-864

Department of Anesthesia, Maulana Azad Medical College, New Delhi, India.

Background And Aims: Second-generation supraglottic airway devices are widely used in current anaesthesia practice. This randomised study was undertaken to evaluate and compare laryngeal mask airway: ProSeal laryngeal mask airway (PLMA), Supreme laryngeal mask airway (SLMA) and I-gel.

Methods: Eighty-four adult patients undergoing elective surgery were randomly allocated to three groups: group (PLMA), group I (I-gel) and group S (SLMA) of 28 patients each. Read More

View Article
November 2018

Development of a Novel Intraoperative Neuromonitoring System Using a Surface Pressure Sensor to Detect Muscle Movement: A Rabbit Model Study.

Clin Exp Otorhinolaryngol 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology, Head and Neck Surgery and Medical Research Institute, Pusan National University College of Medicine, Busan, Korea.

Objectives: False-negative or false-positive responses in intraoperative neuromonitoring (IONM) using electromyography (EMG) in thyroid surgery pose a challenge. Therefore, we developed a novel IONM system that uses a surface pressure sensor instead of EMG to detect muscle twitching. This study aimed to investigate the feasibility and safety of a new IONM system using a piezo-electric surface pressure sensor in an experimental animal model. Read More

View Article
December 2018

Symmetrical Apophyses on the Posterior Margins of the Thyroid Cartilage: A Previously Undescribed Anatomical Variation With Potential Forensic Implications.

Am J Forensic Med Pathol 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Anatomía y Embriología Humana Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

Differential diagnosis between normal/variant anatomy and pathological/traumatic findings represents one of the main matters of investigation of the so-called forensic clinical anatomy. In the literature, many anatomical variations of the laryngeal thyroid cartilage have been reported, with potential implications in forensic pathology. They include triticeal cartilages, foramen thyroideum, asymmetry, segmentation or agenesis of the superior thyroid horns, bone connections with the hyoid bone, absence of cricothyroid facets, hypertrophy of the inferior thyroid tubercle, and asymmetries in the thyroid notch, isthmus, or length of the inferior horn. Read More

View Article
December 2018
1 Read

Inhalational injury and the larynx: A review.

Burns 2018 Dec 7. Epub 2018 Dec 7.

Department of Paediatrics Otolaryngology Head & Neck Surgery, Princess Margaret Hospital for Children, Roberts Road, Subiaco, Western Australia 6008, Australia; Murdoch ENT, Wexford Medical Centre, St John of God Hospital (Murdoch), Suite 17-18, Level 1, 3 Barry Marshall Parade, Murdoch, Western Australia 6150, Australia; School of Surgery, University of Western Australia, Stirling Highway, Crawley, Perth, Western Australia 6009, Australia; St John of God Hospital (Murdoch), Wexford Medical Center, Suite 17-18, Level 1, 3 Barry Marshall Parade, Murdoch 6150, Western Australia, Australia.

Objective: To review and discuss the existing research on the pathophysiology, impact and management of inhalational injury on the larynx and lower respiratory tract.

Data Sources: A literature search was conducted on the PubMed, MedLine, Embase, Web of Science and Google Scholar databases based on the keywords "airway burn", "inhalational injury" and "larynx".

Review Methods: Inclusion criteria included English language studies containing original and review data on airway injury. Read More

View Article
December 2018

Comparison of Maximum Oxygen Uptake and Rating Perceived Exertion in Woman's Kabaddi Athletes (Without Breathy Voice to Severe Breathy Voice).

J Voice 2018 Dec 7. Epub 2018 Dec 7.

Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.. Electronic address:

Objective: There is limited research on voice problems of athletes, especially Kabaddi athletes who use their voice during Kabaddi exercises and may damage their vocal folds and impair their voice quality. The present study aimed to compare maximum oxygen uptake (VOmax) and rating perceived exertion (RPE) in Woman's Kabaddi athletes without breathy voice (BV) to severe BV.

Materials And Methods: Seventy woman's Kabaddi athletes (mean age of 20. Read More

View Article
December 2018

Transcutaneous Electrical Nerve Stimulation Combined With Voice Therapy in Women With Muscle Tension Dysphonia.

J Voice 2018 Dec 7. Epub 2018 Dec 7.

Department of Speech and Language Pathology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

Objectives: The purpose of the present study was to investigate the effect of Voice Therapy (VT) with and without Transcutaneous Electrical Nerve Stimulation (TENS) in women with Muscle Tension Dysphonia (MTD).

Methods: A total of 20 women with MTD participated in the study. Participants underwent evaluation of auditory-perceptual assessment, acoustic voice analysis, Vocal Tract Discomfort (VTD), and musculoskeletal pain before and after the treatment. Read More

View Article
December 2018

A Homozygous Nonsense Mutation in the DSG3 Gene Causes Acantholytic Blisters in the Oral and Laryngeal Mucosa.

J Invest Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

View Article
December 2018

Quantitative analysis of carotid arterial calcification using airway CT in obstructive sleep apnea.

Auris Nasus Larynx 2018 Dec 6. Epub 2018 Dec 6.

Department of Otorhinolaryngology-Head and Neck Surgery, Dong-A University College of Medicine, Busan, Republic of Korea.

Objective: To evaluate the relationship between obstructive sleep apnea (OSA) severity and carotid arterial calcification by quantitative analysis using airway computed tomography (CT).

Methods: This study included a total of 180 consecutive OSA patients aged 45-80years underwent polysomnography and airway CT between March 2014 and October 2016. The subjects were divided into three groups based on the results of the respiratory disturbance index (RDI): mild (RDI 5-14, n=29), moderate (RDI 15-29, n=50), and severe (RDI≥30, n=101). Read More

View Article
December 2018
2 Reads

Outcomes of carotid-subclavian bypass performed in the setting of thoracic endovascular aortic repair.

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC. Electronic address:

Background: Subclavian artery revascularization is frequently performed in the setting of thoracic endovascular aortic repair (TEVAR). However, there is little information on the short- and long-term outcomes of patients undergoing carotid to subclavian artery bypass in this clinical setting. As such, this study sought to define the early and late outcomes associated with this procedure. Read More

View Article
October 2018

Endoscopic sinus surgery with and without computer assisted navigation: A retrospective study.

Auris Nasus Larynx 2018 Dec 5. Epub 2018 Dec 5.

Department of Adult and Development Age Human Pathology "Gaetano Barresi", Unit of Otorhinolaryngology, University of Messina, Italy.

Objective: In the last years endoscopic sinus surgery (ESS) is improved with the introduction of computer assisted navigation (CAN). In this retrospective study we evaluated the usefulness of CAN in endoscopic sinus surgery and studied its advantages over conventional endoscopic sinus surgery.

Methods: We retrospectively reviewed the records of 96 patients with chronic rhinosinusitis (CRS). Read More

View Article
December 2018
1 Read

Risk factors and distribution features of level IB lymph nodes metastasis in nasopharyngeal carcinoma.

Auris Nasus Larynx 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, 330029, PR China. Electronic address:

Objective: The objective of this study is to investigate the risk factors and distribution features for level IB metastasis in nasopharyngeal carcinoma (NPC) and provide clinical evidence for defining the indications and clinical target volume (CTV) of prophylactic level IB irradiation.

Methods: We retrospectively analyzed 798 patients with newly-diagnosed, non-metastatic and histologically confirmed NPC underwent intensity-modulated radiation therapy (IMRT). Two sides of neck in each patient have been analyzed separately. Read More

View Article
December 2018

Vocal Health, Voice Self-concept and Quality of Life in German School Teachers.

J Voice 2018 Dec 4. Epub 2018 Dec 4.

Freiburg Institute of Musicians' Medicine, Faculty of Medicine, Medical Center University of Freiburg, University of Music Freiburg, University of Freiburg, Germany.

Objectives: For school teachers, the voice is a mandatory occupational tool during teaching. Several studies, however, proved that teachers are at high risk of developing voice disorders. The aim of this study was to investigate the voice health, voice self-concept, and quality of life in German teachers. Read More

View Article
December 2018

Nasal nitric oxide in the inferior turbinate surface decreases with intranasal steroids in allergic rhinitis: A prospective study.

Auris Nasus Larynx 2018 Dec 4. Epub 2018 Dec 4.

Department of Otorhinolaryngology, Head and Neck Surgery, Division of Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

Objective: It remains controversial whether nasal nitric oxide (NO) serves as a reliable parameter to evaluate treatment efficacy in patients with allergic rhinitis (AR). The measurement of local nasal NO levels has been shown to be a sensitive marker for the diagnosis of symptomatic AR patients. Here we assessed the applicability of nasal NO to evaluations of the efficacy of intranasal steroids (INS) in a prospective design. Read More

View Article
December 2018

Translational Study on Recurrent Laryngeal Nerve Temperature Susceptibility.

J Surg Res 2019 Feb 27;234:7-12. Epub 2018 Sep 27.

Division for Endocrine Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi," University Hospital G. Martino, University of Messina, Messina, Italy.

Background: Recurrent laryngeal nerve (RLN) injury is the most common and serious complication after thyroid surgery. However, little is known about the temperature threshold leading to RLN injury. In this study, we investigated threshold temperatures that cause RLN injury during thyroid surgery using continuous intraoperative neuromonitoring in swine models. Read More

View Article
February 2019

Spondin-2 is a novel diagnostic biomarker for laryngeal squamous cell carcinoma.

Pathol Res Pract 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, Affiliated Hospital of Nantong University, No. 20 Xi Si Road, Nantong, 226001, China. Electronic address:

Spondin-2, belongs to the SOX (SRY-related HMG box) gene family, plays a vital role in the development of malignancy, however, the role of Spondin-2 in laryngeal squamous cell carcinoma (LSCC) remains unknown. The aim of this study is to investigate the prognostic significance of and probable mechanism of Spondin-2 in LSCC. qRT-PCR, western blotting assays and IHC analysis demonstrated that Spondin-2 was significantly increased in LSCC tissues compared with adjacent non-tumorous tissues. Read More

View Article
November 2018

Patients with locally advanced hypopharyngeal carcinoma. Results over a 30-year period.

Acta Otorrinolaringol Esp 2018 Dec 5. Epub 2018 Dec 5.

Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.

Introduction And Objectives: The treatment of locally advanced carcinomas of the hypopharynx may include surgery or several combinations of radiotherapy and chemotherapy as organ preservation strategies. The objective of the present study is to analyze the results of locally advanced hypopharyngeal carcinoma patients treated in a single centre over a 30-year period.

Methods: Retrospective chart review of 278 patients with T3-T4 hypopharyngeal carcinomas treated between 1985 and 2015 at a tertiary institution. Read More

View Article
December 2018

Treatment of early-stage laryngeal cancer: A comparison of treatment options.

Oral Oncol 2018 Dec 16;87:8-16. Epub 2018 Oct 16.

Stanford University School of Medicine, Department of Otolaryngology Head and Neck Surgery, USA.

Over the course of the last several decades, the treatment options for early laryngeal cancers (T1 and T2) have evolved; however, simultaneously the mortality rate has increased. As larynx preservation approaches have become the standard of care, the selection of the proper treatment modality has become paramount. Radiation therapy or transoral laser microsurgery are the most common options for treatment of these early lesions. Read More

View Article
December 2018

Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.

Oral Oncol 2018 Dec 3;87:131-137. Epub 2018 Nov 3.

Radiation Oncology Department, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Sorbonne University, Paris, France.

Target volume selection and delineation for both the primary tumor and the lymph nodes are critical steps in the treatment of head and neck tumors with Intensity Modulated Radiation therapy (IMRT). These steps should be based on a probabilistic approach, which is that selection and delineation will be considered as optimal when reaching the best compromise between a too tight volume that could be associated to an unacceptable rate of local recurrence, and a too large volume, which could be associated to an unacceptable rate of treatment morbidity. Failure to do so have been reported to be associated to a higher risk of loco-regional recurrences and/or morbidity after treatment. Read More

View Article
December 2018

Salvage Surgery for Recurrence after Radiotherapy for Squamous Cell Carcinoma of the Head and Neck.

Otolaryngol Head Neck Surg 2018 Dec 11:194599818818443. Epub 2018 Dec 11.

1 Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Objective: Most studies that report on salvage surgery after primary radiotherapy for head and neck squamous cell carcinoma (HNSCC) are small and heterogeneous. Subsequently, some relevant questions remain unanswered. We specifically focused on (1) difference in prognosis per tumor subsite, corrected for disease stage, and (2) differences in prognosis after salvage surgery for local, regional, and locoregional recurrences. Read More

View Article
December 2018

Outcomes of Treating Early Glottic Neoplasms With a Potassium Titanyl Phosphate Laser.

Ann Otol Rhinol Laryngol 2018 Dec 11:3489418806914. Epub 2018 Dec 11.

2 Auckland City Hospital, Auckland, New Zealand.

Objectives:: The aim of this study was to assess the outcome of treating glottic dysplasia and early squamous cell carcinoma (SCC) with potassium titanyl phosphate (KTP) photoangiolytic laser ablation.

Methods:: Patient demographics, comorbidities, and tumor characteristics were recorded. Perceptual, patient-reported, and objective voice outcomes were assessed. Read More

View Article
December 2018
1 Read

Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision-tree analysis.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Otolaryngology Department, Hospital Clínic, Barcelona, Spain.

Background: Indications of transoral laser microsurgery (TLM) are conditioned by the risk of local relapse.

Objective: To evaluate prognostic factors of local relapse and local control with TLM (LC-TLM).

Methods: Local relapse and LC-TLM were evaluated in 1119 patients. Read More

View Article
December 2018

Early experience of transoral thyroidectomy: Comparison of robotic and endoscopic procedures.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The aim of this study was to evaluate the feasibility, safety, and early surgical outcomes of transoral thyroidectomy and to compare robotic and endoscopic procedures.

Methods: A total of 37 patients underwent robotic (23 cases) or endoscopic (14 cases) transoral thyroidectomy. We compared the outcomes of the two procedures. Read More

View Article
December 2018
5 Reads

Unexpected discrepancies in hospital administrative databases can impact the accuracy of monitoring thyroid surgery outcomes in France.

PLoS One 2018 6;13(12):e0208416. Epub 2018 Dec 6.

Department of General and Endocrine Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.

Objective: To determine the validity of hospital administrative databases compared to prospective collection of medical data assessing thyroid surgery complications.

Background: Administrative data are increasingly used to track surgical outcomes.

Methods: All patients undergoing thyroid surgery at three French university hospitals between April 2008 and April 2009 were prospectively included. Read More

View Article
December 2018
1 Read

How radical is total parathyroidectomy in patients with renal hyperparathyroidism?

Langenbecks Arch Surg 2018 Dec 5. Epub 2018 Dec 5.

Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Waehringer Gürtel 18-20, A-1090, Vienna, Austria.

Purpose: Total parathyroidectomy (tPTX) in patients with renal hyperparathyroidism (RHPT) aims at the complete removal of all hyperfunctioning parathyroid tissue. Whenever parathyroidectomy is termed "total," undetectable postoperative parathyroid hormone (PTH) levels within the first postoperative week are expected. The aim of this study was to evaluate if tPTX is technically possible using a radical surgical procedure. Read More

View Article
December 2018

Assessing the Efficacy of Ventilation of Anesthetized Neonatal Calves Using a Laryngeal Mask Airway or Mask Resuscitator.

Front Vet Sci 2018 21;5:292. Epub 2018 Nov 21.

Department of Production Animal Health, University of Calgary Faculty of Veterinary Medicine, Calgary, AB, Canada.

Calves that have undergone a dystocia are often hypoxic and acidemic, which can result in reduced vigor and subsequent mortality. Methods of field resuscitation of apneic newborn calves are often ineffective and therefore underutilized. This proof-of-concept study aimed to determine the efficacy of the laryngeal mask airway (LMA) as well as the current industry standard method of ventilation, the McCulloch Calf Aspirator/ Resuscitator (MMR) for positive pressure ventilation of neonatal calves. Read More

View Article
November 2018

Identification of Integrin β1 as a Novel PAG1-Interacting Protein Involved in the Inherent Radioresistance of Human Laryngeal Carcinoma.

J Cancer 2018 18;9(22):4128-4138. Epub 2018 Oct 18.

Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.

Inherent radioresistance plays a crucial role in the failure of radiotherapy. Using the inherent radioresistant (Hep-2max) and radiosensitive (Hep-2min) cell lines established from the parental cell line Hep-2, we previously reported that phosphoprotein associated with glycosphingolipid-enriched microdomains 1(PAG1) overexpression in laryngeal carcinoma cells was correlated with inherent radioresistant phenotypes. However, the underlying mechanisms of this effect remain unknown. Read More

View Article
October 2018

Impact of the anterior commissure involvement on the survival of early glottic cancer treated with cricohyoidoepiglottopexy: a retrospective study.

Cancer Manag Res 2018 8;10:5553-5558. Epub 2018 Nov 8.

Otolaryngology, Department of Health Sciences, University of Catanzaro, Catanzaro, Italy,

Background: Laryngeal early glottic tumors can benefit from different treatment modalities, including transoral laser microsurgery, open partial horizontal laryngectomy (OPHL), and radiotherapy. However, the treatment of early glottic tumors with the involvement of the anterior commissure remains controversial. The studies about the role of anterior commissure involvement in oncologic outcomes in patients with early glottic cancer treated with supracricoid laryngectomy (SCL) are very few. Read More

View Article
November 2018