20,168 results match your criteria Laryngeal Carcinoma


Salvage surgery in head and neck cancer: External validation of predictors of disease-specific survival.

Oral Oncol 2020 Jun 29;109:104876. Epub 2020 Jun 29.

Department of Otolaryngology-Head and Neck Surgery, University Hospital de la Santa Creu i Sant Pau, Universitat Autonòma de Barcelona, Barcelona, Spain.

Objective: Salvage surgery in recurrent head and neck squamous cell carcinoma (HNSCC) is associated with poor outcomes. There is great interest to better identify suitable surgical patients. This study aimed to validate the proposal of Hamoir et al. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104876DOI Listing

Which Larynx-Preservation Strategy Would Be Best for a Patient With Resectable, Locally Advanced, Hypopharynx Squamous Cell Carcinoma?

Oncology (Williston Park) 2020 Jun;34(6):211-215

LP strategies should be considered only in patients with resectable stage III/IV larynx and hypopharynx SCC, ideally those who have a functional larynx. The choice of treatment must be discussed by a multidisciplinary team, and the patient must have an active role in making the decision. CRT and IC-RT are both approved larynx-preservation approaches. Read More

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Occult Metastasis in Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Ann Otol Rhinol Laryngol 2020 Jul 1:3489420937744. Epub 2020 Jul 1.

Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Objective: The incidence of occult metastasis (OM) in laryngeal squamous cell carcinoma (SCC) is still widely debated. In this systematic review, we aim to determine the rate of OM in laryngeal SCC, its impact on recurrence, and the role of elective neck dissection (END) in the management of the clinically negative neck.

Methods: A systematic review of the English-language literature in Web of Science, PubMed, MEDLINE, and Cochrane Library databases on occult metastasis in laryngeal SCC from 1977 to 2018 was conducted. Read More

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http://dx.doi.org/10.1177/0003489420937744DOI Listing

CCNY Accelerates Cylcin E Expression to Regulate the Proliferation of Laryngeal Carcinoma Cells via MEK/ERK Signaling Pathway.

Cancer Manag Res 2020 23;12:4889-4898. Epub 2020 Jun 23.

Beijing YouAn Hospital, Capital Medical University, Beijing, People's Republic of China.

Background: Laryngeal carcinoma is a common cancer among head and neck tumors, accounting for 0.5-1% new cancer cases or deaths of all tumors throughout the body. Despite improvements in diagnostic and therapy, the prognosis of laryngeal carcinoma patients still remains poor. Read More

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http://dx.doi.org/10.2147/CMAR.S241620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320751PMC

Diagnostic Role of Dysregulated Circular RNA hsa_circ_0036722 in Laryngeal Squamous Cell Carcinoma.

Onco Targets Ther 2020 17;13:5709-5719. Epub 2020 Jun 17.

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital of Fudan University, Shanghai, People's Republic of China.

Purpose: Dysregulated circular RNAs (circRNAs) have been shown to play important roles in various cancers, and could serve as diagnostic biomarkers. However, research focusing on the roles of the circRNAs in laryngeal squamous cell carcinoma (LSCC) is limited. This research aimed to explore the expressions of hsa_circ_0036722 in LSCCs and its diagnostic significance. Read More

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http://dx.doi.org/10.2147/OTT.S231076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306465PMC

HCV infection and the risk of head and neck cancer: A meta-analysis.

Oral Oncol 2020 Jun 26;109:104869. Epub 2020 Jun 26.

Department of Neurosciences, Section of Otolaryngology, University of Padova, Treviso, Italy. Electronic address:

Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a meta-analysis was performed to summarize present evidence on the association between HCV infection and HNSCC. After screening citations from literature search, eight observational studies investigating the association between HCV and cancer(s) of either oral cavity, oropharynx, hypopharynx or larynx were included. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104869DOI Listing

Predictors of chemotherapy and its effects in early stage squamous cell carcinoma of the larynx.

Laryngoscope Investig Otolaryngol 2020 Jun 24;5(3):445-452. Epub 2019 Dec 24.

Division of Radiation Oncology Allegheny Health Network Cancer Institute, Allegheny General Hospital Pittsburgh PA.

Background: Squamous cell carcinoma (SCC) of larynx is a common head and neck cancer. For cases that are node negative, the role of definitive concurrent chemoradiation is unclear and not supported by guidelines but used at provider discretion. To address this knowledge gap, we examined the oncological outcomes with additional chemotherapy and factors correlated with the chemotherapy administration. Read More

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http://dx.doi.org/10.1002/lio2.327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314463PMC

Acupuncture Therapy in Post-Radiation Head-and-Neck Cancer with Dysgeusia.

Med Acupunct 2020 Jun 16;32(3):157-162. Epub 2020 Jun 16.

Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Jakarta, Indonesia.

Radiation therapy for head-and-neck cancer can cause side-effects, including pain, nausea, vomiting, sensory disorders such as anosmia and dysgeusia, dysphagia, xerostomia, hot flashes, fatigue, sleep disorders, and even anxiety and depression disorders. Therapies using acupuncture are now being adopted at cancer therapy centers. Acupuncture has been clinically proven to reduce the side-effects of cancer therapies, thus, resulting in better quality of life. Read More

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http://dx.doi.org/10.1089/acu.2020.1410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310235PMC

POSITIVE EXPRESSION OF NEDD9 IN HEAD AND NECK CANCER IS RELATED TO BETTER SURVIVAL PERIOD.

Acta Clin Croat 2019 Dec;58(4):655-661

1Division of Head and Neck Surgery, Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Otorhinolaryngology and Head and Neck Surgery, Zagreb University Hospital Centre, Zagreb, Croatia; 3Department of Pathology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 4Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

The aim was to determine immunohistochemical expression of NEDD9 protein in head and neck squamous cell carcinoma (HNSCC) and the possible relation of its expression with primary tumor size (T), regional lymph node status (N), stage of disease (TNM) and survival period. A total of 131 patients with primary tumor localization in the area of oropharynx, hypopharynx and larynx, monitored for at least 5 years after initial surgical treatment were analyzed. The study included 128 male and three female patients, median age 62. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314307PMC
December 2019

Carcinoma of the posterior wall of the hypopharynx: surgical treatment with larynx preservation.

Braz J Otorhinolaryngol 2020 Jun 15. Epub 2020 Jun 15.

Koç University, School of Medicine, Department of Otolaryngology, Istanbul, Turkey. Electronic address:

Introduction: Posterior pharyngeal wall is the most rare subsite for hypopharyngeal carcinomas. Because of its rarity, there are few studies published in the literature specifically concerning posterior pharyngeal wall carcinoma.

Objectives: To report our functional results in patients with the carcinoma of the posterior wall of the hypopharynx after surgical treatment by resection via a lateral or infrahyoid pharyngotomy approach, with the preservation of the larynx and reconstruction with a radial forearm free flap. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.05.013DOI Listing

Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck.

Head Neck 2020 Jun 27. Epub 2020 Jun 27.

Department of Medicine, Division of General Internal Medicine, Mount Sinai Hospital, New York, New York, USA.

Background: Neutrophil-to-lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States.

Methods: We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. Read More

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http://dx.doi.org/10.1002/hed.26329DOI Listing

Prophylactic lymph node dissection in clinically N0 differentiated thyroid carcinoma: example of personalized treatment.

Per Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Pharmacology - Clinical Pharmacology Unit, National & Kapodistrian University of Athens, Faculty of Medicine, Building 16, 1st Floor, 75 Mikras Asias, 11527-Goudi, Athens, Greece.

Considering the 'differentiated thyroid carcinoma (DTC) epidemic', the indolent nature of DTC imposes a treatment paradigm shift toward elimination of recurrence. Lymph node metastases in cervical compartments, encountered in 20-90% of DTC, are the main culprit of recurrent disease, affecting 5-30% of patients. Personalized risk-stratified cervical prophylactic lymph node dissection (PLND) at initial thyroidectomy in DTC with no clinical, sonographic or intraoperative evidence of lymph node metastases (clinically N0) has been advocated, though not unanimously. Read More

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http://dx.doi.org/10.2217/pme-2019-0119DOI Listing

Expression of let-7i and miR-192 is associated with resistance to cisplatin-based chemoradiotherapy in patients with larynx and hypopharynx cancer.

Oral Oncol 2020 Jun 22;109:104851. Epub 2020 Jun 22.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam, the Netherlands. Electronic address:

Objectives: The majority of patients with locally advanced larynx or hypopharynx squamous cell carcinoma are treated with organ-preserving chemoradiotherapy (CRT). Clinical outcome following CRT varies greatly. We hypothesized that tumor microRNA (miRNA) expression is predictive for outcome following CRT. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104851DOI Listing

Efficacy of Nivolumab for Head and Neck Cancer Patients with Primary Sites and Histological Subtypes Excluded from the CheckMate-141 Trial.

Cancer Manag Res 2020 3;12:4161-4168. Epub 2020 Jun 3.

Department of Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.

Background: In the CheckMate-141 trial, nivolumab conferred a survival benefit in patients with recurrent or metastatic refractory squamous cell carcinoma (SCC) head and neck cancer (HNC). Here, we examined the efficacy of nivolumab in patients with histological subtypes or primary sites of HNC not included in the CheckMate-141 trial.

Methods: This was a retrospective analysis of data collected prospectively from 97 patients who were treated with nivolumab for recurrent or metastatic HNC at our institution. Read More

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http://dx.doi.org/10.2147/CMAR.S249393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280058PMC

Postoperative Concurrent Chemoradiotherapy versus Postoperative Radiotherapy Alone for Larynx Squamous Cell Carcinoma Patients with Lymphovascular Invasion: A Propensity Score Matching Study.

Cancer Manag Res 2020 29;12:4063-4071. Epub 2020 May 29.

Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Purpose: To date, no guidelines have been proposed for the ideal treatment of postoperative larynx squamous cell carcinoma (LSCC) patients with lymphovascular invasion due to a lack of similar studies. The present study was conducted to compare the survival and toxicity in LSCC patients with lymphovascular invasion receiving either postoperative radiotherapy (PORT) or postoperative chemoradiotherapy (POCRT). The results can be applied for more appropriate treatment of these patients. Read More

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http://dx.doi.org/10.2147/CMAR.S250621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269631PMC

Hypertension is associated with oral, laryngeal, and esophageal cancer: a nationwide population-based study.

Sci Rep 2020 Jun 24;10(1):10291. Epub 2020 Jun 24.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Several studies have reported an association between hypertension and upper aerodigestive tract cancer, but no large-scale, population-based studies have been conducted to confirm this.The aim of this study was to explore the association between hypertension and risk of upper aerodigestive tract cancer in Koreans. Participants who underwent a national health screening examination from January 1 to December 31, 2009 (n = 9,746,606) were enrolled. Read More

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http://dx.doi.org/10.1038/s41598-020-67329-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314820PMC

Letter to "Medial lingual lymph node metastasis in carcinoma of the tongue".

Auris Nasus Larynx 2020 Jun 21. Epub 2020 Jun 21.

Unit of Radiation Oncology, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1016/j.anl.2020.05.023DOI Listing

Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management.

Cancers (Basel) 2020 Jun 22;12(6). Epub 2020 Jun 22.

Division of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Laryngeal squamous cell carcinoma is the second most common head and neck cancer. Its pathogenesis is strongly associated with smoking. The management of this disease is challenging and mandates multidisciplinary care. Read More

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http://dx.doi.org/10.3390/cancers12061651DOI Listing

Multiple primary malignancies involving lung cancer: a single-center experience.

Tumori 2020 Jun 24:300891620933678. Epub 2020 Jun 24.

Thoracic Surgery, Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy.

Objective: Currently, unlike earlier years, patients affected by multiple primary malignancies (MPM) are significantly increased, thus representing a clinical-pathologic category worthy of attention. Their clinical features and prognosis still need to be studied thoroughly, and this is the aim of our study.

Methods: Patients with MPM involving lung cancer admitted in our center between January 2006 and December 2016 were considered. Read More

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http://dx.doi.org/10.1177/0300891620933678DOI Listing

Expression levels of SCCA and CYFRA 21-1 in serum of patients with laryngeal squamous cell carcinoma and their correlation with tumorigenesis and progression.

Authors:
M Ji L J Zhang

Clin Transl Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Kuiwen District, Weifang, 261031, P.R. China.

Purpose: To explore the concentration of squamous cell carcinoma antigen (SCCA), cytokeratin fragment antigen 21-1 (CYFRA21-1) in patients with laryngeal squamous cell carcinoma (LSCC) and its correlation with tumorigenesis and progression.

Methods: A total of 78 patients with LSCC admitted to our hospital from February 2010 to January 2016 were enrolled as the research group (RG), and another 41 healthy volunteers from the same period were selected as the control group (CG). The serum concentrations of SCCA and CYFRA21-1 in patients with LSCC were detected by ELISA, whose diagnostic value in LSCC were further analyzed by ROC curve. Read More

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http://dx.doi.org/10.1007/s12094-020-02417-4DOI Listing

RalB degradation by dihydroartemisinin induces autophagy and IFI16/caspase-1 inflammasome depression in the human laryngeal squamous cell carcinoma.

Chin Med 2020 19;15:64. Epub 2020 Jun 19.

Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, 050081 China.

Background: Interferon-inducible 16 (IFI16)/caspase-1 inflammasome activates and secretes IL-1β. However, it is still unclear whether the IFI16 inflammasome is involved in human laryngeal squamous cell carcinoma. Autophagy directly removed inflammasome components and limited early IL-1β production. Read More

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http://dx.doi.org/10.1186/s13020-020-00340-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304197PMC

Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms () in Laryngeal Squamous Cell Carcinoma.

Cancer Genomics Proteomics 2020 Jul-Aug;17(4):431-439

Department of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Background/aim: The study aimed to evaluate associations of relative leukocyte telomere length (LTL) and polymorphisms of telomere length-associated genes TERT (rs2736098), TERT-CLPTM1L (rs401681), TRF1 (rs1545827, rs10107605) and TNKS2 (rs10509637, rs10509639) in patients with laryngeal squamous cell carcinoma (LSCC).

Materials And Methods: The study consisted of 300 patients with LSCC and 369 healthy control subjects. Genotyping and relative LTL measuring were carried out using qPCR. Read More

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http://dx.doi.org/10.21873/cgp.20202DOI Listing

Unsymmetrically-Substituted 5,12-dihydrodibenzo[,][1,4]diazocine-6,11-dione Scaffold-A Useful Tool for Bioactive Molecules Design.

Molecules 2020 Jun 20;25(12). Epub 2020 Jun 20.

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warszawa, Poland.

Unsymmetrically -substituted and -disubstituted 5,12-dihydrodibenzo [,][1,4]diazocine-6,11-diones were synthesized in the new protocol. The desired modifications of the dibenzodiazocine scaffold were introduced at the stages of proper selection of building blocks as well as post-cyclization modifications with alkylation or acylation agents, expanding the structural diversity and possible applications of synthesized molecules. The extension of developed method resulted in the synthesis of novel: tricyclic 5,10-dihydrobenzo[]thieno[3,4-][1,4]diazocine-4,11-dione scaffold and fused pentacyclic framework possessing two benzodiazocine rings within its structure. Read More

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http://dx.doi.org/10.3390/molecules25122855DOI Listing

STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-β1.

Eur Rev Med Pharmacol Sci 2020 Jun;24(11):6166-6174

Department of Maxillofacial Surgery, Weifang People's Hospital, Weifang, China.

Objective: The aim of this study was to uncover the expression characteristic and biological function of STYK1 in the progression of laryngeal squamous cell carcinoma (LSCC), and to explore the underlying mechanism.

Patients And Methods: Expression level of STYK1 in 44 paired LSCC and adjacent normal tissues was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between STYK1 level and clinical parameters of LSCC patients was analyzed. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21512DOI Listing

Comparison of long-term treatment outcomes of T2N0M0 laryngeal squamous cell carcinoma using different treatment methods.

Oncol Lett 2020 Jul 14;20(1):921-930. Epub 2020 May 14.

Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeollanam 519-763, Republic of Korea.

Early [stage I and II (T2N0M0)] laryngeal cancer types are currently recommended to be treated with a single modality, consisting of definitive radiation therapy or larynx-preserving surgery. Although the treatment outcomes of stage I are good, the frequency of successful outcomes decreases with T2N0M0. Therefore, the present study investigated the treatment outcomes of different treatment methods in T2N0M0 laryngeal cancer. Read More

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http://dx.doi.org/10.3892/ol.2020.11628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285832PMC

Long non-coding RNA AC023794.4-201 exerts a tumor-suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker.

Oncol Lett 2020 Jul 7;20(1):774-784. Epub 2020 May 7.

Department of Otorhinolaryngology and Head and Neck Surgery, Li Huili Hospital Affiliated to Ningbo University, Ningbo, Zhejiang 315040, P.R. China.

After the expression level of lncRNA AC023794.4-201 was upregulated in 2 laryngeal squamous cell carcinoma (LSCC) cell lines (AMC-HN-8 and TU-212) and LSCC xenografts, the biological function of lncRNA AC023794.4-201 in LSCC was further investigated using and experiments, such as cell function experiments and nude mice transplantation. Read More

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http://dx.doi.org/10.3892/ol.2020.11595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286120PMC

Impact of the first month of Covid-19 lockdown on oncologic surgical activity in the Ile de France region university hospital otorhinolaryngology departments.

Eur Ann Otorhinolaryngol Head Neck Dis 2020 Jun 13. Epub 2020 Jun 13.

Service d'ORL et de Chirurgie Cervico-Faciale, Université Paris Nord, AP-HP, Hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France.

Objective: To evaluate the impact of the first month of lockdown related to the Covid-19 epidemic on the oncologic surgical activity in the Ile de France region university hospital otorhinolaryngology departments.

Material And Methods: A multicenter prospective observational assessment was conducted in 6 university hospital otorhinolaryngology departments (Paris Centre, Nord, Est and Sorbonne) during the 1-month periods before (Month A) and after (Month B) lockdown on March 17, 2020. The main goal was to evaluate lockdown impact on oncologic surgical activity in the departments. Read More

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http://dx.doi.org/10.1016/j.anorl.2020.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293504PMC

Label-Free Semiquantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics Analysis of Laryngeal/Hypopharyngeal Squamous Cell Carcinoma on Formalin-Fixed, Paraffin-Embedded Tissue Samples - a Pilot Study.

Pathol Oncol Res 2020 Jun 21. Epub 2020 Jun 21.

Medical School, Institute of Biochemistry and Medical Chemistry, University of Pecs, Szigeti Str 12, Pecs, H-7624, Hungary.

Squamous cell carcinoma (SCC) of the head and neck region is the sixth most frequent malignancy with high mortality rate. Due to its poor prognosis it is considered a growing public health problem worldwide inspite of existing treatment modalities. Thus, early diagnosis of new diseases and recurrences is emerging on one hand, but on the other hand troublesome in the lack of reliable tumor markers in this field. Read More

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http://dx.doi.org/10.1007/s12253-020-00849-5DOI Listing

Three-Field versus Two-Field Lymphadenectomy for Esophageal Squamous Cell Carcinoma: A Meta-Analysis.

J Surg Res 2020 Jun 18;255:195-204. Epub 2020 Jun 18.

Department of Orthopedics, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Background: Most surgeons now accept lymphadenectomy as an essential feature of the operative treatment of esophageal squamous cell carcinoma. Three-field and two-field lymphadenectomy are two of the most popular excision scopes among surgeons. Over recent years, researchers have performed a range of comparative studies regarding these techniques, although the conclusions remain inconsistent. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.057DOI Listing
June 2020
1.936 Impact Factor

The Functional Role of Long Non-coding RNA UCA1 in Human Multiple Cancers: a Review Study.

Curr Mol Med 2020 Jun 19. Epub 2020 Jun 19.

Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan. Iran.

In various cancers, high-grade tumor and poor survival rate in patients with upregulated lncRNAs UCA1 have been confirmed. Urothelial carcinoma associated 1 (UCA1) is an oncogenic non-coding RNA with a length of more than 200 nucleotides. The UCA1 regulate critical biological processes that are involved in cancer progression, including cancer cell growth, invasion, migration, metastasis, and angiogenesis. Read More

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http://dx.doi.org/10.2174/1566524020666200619124543DOI Listing

Long noncoding RNA DLEU2 predicts a poor prognosis and enhances malignant properties in laryngeal squamous cell carcinoma through the miR-30c-5p/PIK3CD/Akt axis.

Cell Death Dis 2020 Jun 18;11(6):472. Epub 2020 Jun 18.

Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwuweiqi Road, 250021, Jinan, Shandong Province, China.

Long noncoding RNAs (lncRNAs) have been identified as potential prognostic tools and therapeutic biomarkers for a variety of human cancers. However, the functional roles and underlying mechanisms of key lncRNAs affecting laryngeal squamous cell carcinomas (LSCCs) are largely unknown. Here, we adopted a novel subpathway strategy based on the lncRNA-mRNA profiles from the Cancer Genome Atlas (TCGA) database and identified the lncRNA deleted in lymphocytic leukemia 2 (DLEU2) as an oncogene in the pathogenesis of LSCCs. Read More

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http://dx.doi.org/10.1038/s41419-020-2581-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303144PMC

Transoral robotic surgery in head and neck district: a retrospective study on 67 patients treated in a single center.

Infect Agent Cancer 2020 15;15:40. Epub 2020 Jun 15.

Maxillofacial & ENT surgery Unit, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", via M. Semmola, Naples, Italy.

Background: The anatomical complexity of the oropharynx and the difficulty in reaching its distal portion have always conditioned the surgical accessibility.Robotic surgery represents an excellent alternative in the treatment of cervico-facial oncological diseases.

Methods: This series comprises all patients managed for head and neck cancer by Trans Oral Robotic Surgery TORS. Read More

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http://dx.doi.org/10.1186/s13027-020-00306-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296635PMC

Impact of Tussigenic Stimuli on Perceived Upper Airway Sensation and Motor Cough Response Following Total Laryngectomy.

Front Physiol 2020 29;11:477. Epub 2020 May 29.

Laboratory of Upper Airway Dysfunction, Department of Speech, Language and Hearing Sciences, University of Florida, Gainesville, FL, United States.

Background: Total laryngectomy (TL) is standard intervention for carcinoma of the head and neck or, in cases of non-functional larynx, as a result of disease or radiation exposure. Laryngeal extirpation serves as a unique human model of both recurrent and superior laryngeal nerve section and offers insight into motor and sensory aspects of cough: both volitional and in response to tussigenic stimuli. While motor changes in cough function are expected among those status post-TL due to postoperative reconstruction of the upper airway, motor cough parameters have not been well described and sensory aspects of cough are unknown in this population, which provides insight into a vagal denervation model in humans. Read More

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http://dx.doi.org/10.3389/fphys.2020.00477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272598PMC

LncRNA SNHG16 Promotes the Progression of Laryngeal Squamous Cell Carcinoma by Mediating miR-877-5p/FOXP4 Axis.

Onco Targets Ther 2020 22;13:4569-4579. Epub 2020 May 22.

Department of Clinical Laboratory, Qingdao Municipal Hospital, Qingdao 266071, People's Republic of China.

Objective: Laryngeal cancer is a common malignant tumor in the ENT, of which laryngeal squamous cell carcinoma (LSCC) accounts for more than 90% of laryngeal cancer. The purpose of this study is to investigate the regulatory mechanism of lncRNA SNHG16 in LSCC.

Materials And Methods: Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to measure mRNA expression. Read More

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http://dx.doi.org/10.2147/OTT.S250752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251222PMC

Platysma skin flap: Laryngeal repair material to produce phonatory flap vibrational wave.

Head Neck 2020 Jun 15. Epub 2020 Jun 15.

Department of Otolaryngology-Head and Neck, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

The platysma skin flap was used for laryngeal reconstruction after vertical partial laryngectomy to improve the postoperative voice quality of patients with T2 and T3 glottic laryngeal carcinoma. Sixty-nine patients with unilateral T2 and T3 glottic laryngeal carcinoma were included. Forty-six patients received vertical partial laryngectomy, and a platysma skin flap was used for laryngeal reconstruction. Read More

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http://dx.doi.org/10.1002/hed.26294DOI Listing

Transoral laser microsurgery for early glottic cancer at a tertiary hospital in Mexico City.

Cir Cir 2020 ;88(3):325-330

Servicio de Otorrinolaringología, Hospital Central Sur de Alta Especialidad de Petróleos Mexicanos (PEMEX), Ciudad de México, México.

Objective: The objective of the study was to analyze the results of endoscopic laser microsurgery for early glottic carcinoma treatment (Stages I and II) at a Tertiary Center in Mexico City.

Materials And Methods: Descriptive, retrospective review of 40 patients with early glottic carcinoma who were treated with endoscopic laser microsurgery with curative intent at our institution from November 2003 to December 2013.

Results: The study yielded 4 pTis, 19 pT1a, 8 pT1b, and 9 pT2 patients. Read More

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http://dx.doi.org/10.24875/CIRU.19001362DOI Listing
January 2020

The knockdown of SNHG3 inhibits the progression of laryngeal squamous cell carcinoma by miR-340-5p/YAP1 axis and Wnt/β-catenin pathway.

Neoplasma 2020 Jun 16. Epub 2020 Jun 16.

Department of Otolaryngology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.

Laryngeal squamous cell carcinoma (LSCC) is a common malignancy of the head and neck. Long noncoding RNAs (lncRNAs) play essential roles in the development and treatment of LSCC. However, the role and regulatory mechanism of lncRNA small nucleolar RNA host gene 3 (SNHG3) in LSCC progression remain largely unknown. Read More

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http://dx.doi.org/10.4149/neo_2020_191022N1073DOI Listing

Proangiogenic signature in advanced laryngeal carcinoma after microRNA expression profiling.

Mol Biol Rep 2020 Jun 12. Epub 2020 Jun 12.

Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University-Sofia, Sofia, Bulgaria.

The aim of this study is to evaluate which dysregulated angiomiRs compose the specific proangiogenic microRNA signature of advanced laryngeal cancer and review the literature. Thirty-six samples from twelve patients with advanced laryngeal carcinoma were collected. Total RNA was extracted and microRNA global profiling was performed using Agilent Technologies Microarray Kit. Read More

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http://dx.doi.org/10.1007/s11033-020-05250-8DOI Listing

Effectiveness of planned surveillance for detecting second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma.

Jpn J Clin Oncol 2020 Jun 13. Epub 2020 Jun 13.

Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: Second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma adversely affect patients' outcomes and the quality of life; however, an adequate surveillance schedule remains unclear.

Methods: We analyzed 330 patients with early esophageal squamous cell carcinoma who underwent endoscopic resection and were registered in the multicenter cohort study to evaluate adequate surveillance for detection of second primary head and neck cancers. Gastrointestinal endoscopists examined the head and neck regions after 3-6 months of endoscopic resection for esophageal squamous cell carcinoma and subsequently every 6 months. Read More

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http://dx.doi.org/10.1093/jjco/hyaa087DOI Listing

Recurrent laryngeal nerve management in transoral endoscopic thyroidectomy.

Oral Oncol 2020 Jun 8;108:104755. Epub 2020 Jun 8.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address:

Introduction: The mechanism of recurrent laryngeal nerve (RLN) injury was investigated during a TransOral Endoscopic Thyroidectomy Vestibular Approach (TOETVA).

Methods: The function of 185 nerves at risk (NAR) was recorded with intermitted intraoperative neural monitoring (I-IONM). The RLN electromyography (EMG) was delineated during: (a) a pre-dissection vagal nerve stimulation; (b) a RLN stimulation at initial visualization; (c) at nerve dissection; and (d) at the final verification of the entire RLN route. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104755DOI Listing

IL-23R in laryngeal cancer: a cancer immunoediting process that facilitates tumor cell proliferation and results in cisplatin resistance.

Carcinogenesis 2020 Jun 12. Epub 2020 Jun 12.

Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Oncogenic pathogens can disturb tissue homeostasis and initiate immune responses for oncogenicity clearance and homeostasis restoration, while failed clearance and chronic inflammation may result in tumorigenesis. The primary tumor development will undergo a cancer immunoediting process, including three phases, termed elimination, equilibrium, and escape. Importantly, immune-edited tumor cells can not only reduce immunogenic molecular expression but also manipulate cytokines within the tumor environment (TME) for immune evasion and tumor proliferation. Read More

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http://dx.doi.org/10.1093/carcin/bgaa058DOI Listing

Expression of E-cadherin and β-catenin in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas.

Acta Otorrinolaringol Esp 2020 Jun 7. Epub 2020 Jun 7.

Servicio de Otorrinolaringología, Hospital Universitario Central de Asturias, ISPA, Oviedo, España; Instituto Universitario de Oncología de Principado de Asturias. Universidad de Oviedo, Oviedo, España.

Introduction And Objectives: Dysfunction of the E-cadherin/catenin complex is directly related to carcinogenesis and metastases development. The aim of this paper is to investigate the prognostic significance of E-cadherin and β-catenin expression in surgically treated laryngeal and hypopharyngeal squamous cell carcinomas.

Material And Methods: Tumour tissue samples were obtained from 133 consecutive patients with squamous cell carcinomas of the head and neck: 68 of the larynx and 65 hypopharyngeal carcinomas, who underwent surgical treatment in our hospital between 2000 and 2005. Read More

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http://dx.doi.org/10.1016/j.otorri.2019.12.002DOI Listing

c-Jun/c-Fos complex in laryngeal squamous cell carcinoma.

J BUON 2020 Mar-Apr;25(2):618-620

Department of Pathology-Cytology, 401 GAH, Athens, Greece.

During laryngeal carcinogenesis, a variety of genomic imbalances are involved in hyperplastic and dysplastic laryngeal epithelia as early or progressive genetic events, respectively. Oncogenes' overactivation is a crucial genetic event in malignant and pre-malignant neoplastic epithelia. Especially, deregulation of crucial pathways including transcription factors - such as c-Fos and c-Jun - leads to an aberrant expression of other crucial genes responsible for cell homeostasis. Read More

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mdm2 oncogene in laryngeal squamous cell carcinoma.

J BUON 2020 Mar-Apr;25(2):594-596

Department of Otorhinolaryngology, Head and Neck Surgery, Medical School, University of Patras.

Laryngeal squamous cell carcinoma (LSCC) demonstrates increasing rates worldwide due to viral-related (High Risk Human Papilloma Virus-HR HPV) persistent infection, cigarette and alcohol consumptions. Gross chromosomal alterations and specific gene aberrations-such as amplifications, deletions, point mutations-combined or not with epigenetic changes are responsible for the progressive transformation of normal squamous epithelia to their malignant phenotype. Among oncogenes that are implicated in the development and progression of LSCC, mouse double minute 2 homolog / murine double minute 2 (mdm2) seems to be an interesting marker for the biological behavior of the malignancy. Read More

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Low expression of miR-20b-5p indicates favorable prognosis in laryngeal squamous cell carcinoma, especially in patients with non-infiltrated regional lymph nodes.

Am J Otolaryngol 2020 May 27;41(5):102563. Epub 2020 May 27.

Third Department of Surgery, University General Hospital "Attikon", Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: Tumor recurrence and distant metastasis are very common in laryngeal squamous cell carcinoma (LSCC). In this study, we examined the potential prognostic value of microRNA-20b-5p (miR-20b-5p), a component of the tumor-related miR-106a/363 cluster.

Materials And Methods: Total RNA was purified from 105 tissue specimens resected from patients having undergone surgical treatment for primary LSCC. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102563DOI Listing

The role of CD133 expression of cancer stem cells on radiotherapy response in early stage glottic cancers.

Eur Arch Otorhinolaryngol 2020 Jun 9. Epub 2020 Jun 9.

Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Purpose: To investigate the relationship between CD133 positivity and radiotherapy (RT) response in early stage glottic laryngeal cancers.

Methods: Thirty seven patients with early-stage glottic laryngeal carcinoma who were treated with primary RT were evaluated. Patients with regular follow-up of at least 3 years were included in the study. Read More

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http://dx.doi.org/10.1007/s00405-020-06106-4DOI Listing

expression might be a novel prognostic biomarker in patients with laryngeal squamous cell carcinoma.

J Int Med Res 2020 Apr;48(4):300060520919252

Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Objectives: This study aimed to explore the expression profile of the Forkhead box protein L2 gene () and to determine its prognostic value and associated epigenetic and genetic alterations in patients with laryngeal squamous cell carcinoma (LSCC).

Materials And Methods: Data for a subset of patients with LSCC (N = 116) were extracted from the head and neck squamous cell carcinoma dataset of The Cancer Genome Atlas and analyzed in relation to expression and survival.

Results: Aberrant expression was an independent prognostic factor for progression-free survival (PFS) (hazard ratio (HR): 2. Read More

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http://dx.doi.org/10.1177/0300060520919252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218937PMC

Curcumin potentiates laryngeal squamous carcinoma radiosensitivity via NF-ΚB inhibition by suppressing IKKγ expression.

J Recept Signal Transduct Res 2020 Jun 9:1-9. Epub 2020 Jun 9.

Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, PR China.

Curcumin has shown efficacy in promoting radiosensitivity combined with radiotherapy. However, the role and mechanism of curcumin on radiosensitivity in laryngeal squamous cell cancer (LSCC) is largely unknown. The aim of our study is to explore the role of IKKγ-NF-κB signaling in curcumin enhancing LSCC cell radiosensitivity . Read More

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http://dx.doi.org/10.1080/10799893.2020.1767649DOI Listing

Prognostic role of programmed death ligand 1 (PD-L1) and the immune microenvironment in laryngeal carcinoma.

Oral Oncol 2020 Jun 5;108:104836. Epub 2020 Jun 5.

Department of Neuroscience DNS, Otolaryngology Section, Padova University, Padova, Italy. Electronic address:

Objectives: The immune system is crucial in the evolution of head and neck cancer. Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic cells and immune cells in the tumor microenvironment. The main aim of this study was to apply univariate/multivariate analysis to investigate the prognostic significance of PD-L1, tumor-infiltrating lymphocytes (TILs), and tertiary lymphoid structures (TLS) in laryngeal carcinoma (LSCC). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104836DOI Listing

Laser Microsurgery Versus Radiotherapy Versus Open Partial Laryngectomy for T2 Laryngeal Carcinoma: A Systematic Review of Oncological Outcomes.

Ear Nose Throat J 2020 Jun 8:145561320928198. Epub 2020 Jun 8.

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Introduction: The aim of the current systematic review is to update the pooled survival outcome of patients with T2 glottic carcinoma treated with either laser surgery (CO transoral laser microsurgery [CO TOLMS]), radiotherapy (RT), or open partial laryngectomy (OPL).

Methods: A systematic search was performed using the MEDLINE database, Scopus, and Google scholar. The inclusion criteria were studies of patients with T2N0 glottic tumor, treated with either primary CO TOLMS, definitive curative RT, or primary OPL, and with reported oncological outcome at 5 years calculated with a Kaplan-Meier or Cox regression method. Read More

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http://dx.doi.org/10.1177/0145561320928198DOI Listing
June 2020
0.881 Impact Factor