Search Our Scientific Publications & Authors

Mol Pharm 2022 Jun 27. Epub 2022 Jun 27.

Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Gastrointestinal anatomical/physiological changes after bariatric surgery influence variables affecting the fate of drugs after ingestion, and medication management of these patients requires a thorough and complex mechanistic analysis. The aim of this research was to study whether loratadine/desloratadine antiallergic treatment of bariatric patients is at risk of being ineffective due to impaired solubility/dissolution. The pH-dependent solubility of loratadine/desloratadine was studied in vitro, as well as ex vivo, in gastric content aspirated from patients before versus after bariatric surgery. Read More

Cureus 2022 May 23;14(5):e25246. Epub 2022 May 23.

General Surgery, West Suburban Medical Center, Chicago, USA.

Laparoscopic adjustable gastric banding (LAGB) over laparoscopic sleeve gastrectomy (LSG) is a rare bariatric surgery. The objective of this case report is to add to the limited literature regarding this procedure. LAGB plus LSG is an effective bariatric procedure for patients that desire additional weight loss who do not qualify for or want gastric bypass. Read More

Surg Obes Relat Dis 2022 May 21. Epub 2022 May 21.

Department of Surgery, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Biomedical and Clinical Sciences, University of Linköping, Norrköping, Sweden.

Background: Mechanical problems at the level of the jejunojejunostomy (JJ) have been identified as a cause of small bowel obstruction (SBO) after laparoscopic Roux-en-Y gastric bypass (RYGB).

Objectives: The objective of the study was to investigate associations between specific surgical techniques used to construct the JJ and the subsequent risk of SBO.

Setting: Nationwide Registry, Sweden. Read More

Ann Med Surg (Lond) 2022 Jun 16;78:103787. Epub 2022 May 16.

Department of General Surgery, University Hospital Brandenburg an der Havel, Hochstraße 29, 14770, Brandenburg an der Havel, Germany.

Background: In bariatric surgery the laparoscopic Roux-en-Y gastric bypass (LRYGB) has been proven to be a safe and effective approach. Currently the optimal size of the linear-stapled gastrojejunostomy (GJ) and its impact on weight loss are not known due to a lack of clinical trials on that topic. We aimed to provide evidence on the impact of the GJ size in terms of gastric bypass weight loss. Read More

JAMA Surg 2022 Jun 22. Epub 2022 Jun 22.

Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.

Importance: Long-term results from randomized clinical trials comparing laparoscopic sleeve gastrectomy (LSG) with laparoscopic Roux-en-Y-gastric bypass (LRYGB) are limited.

Objective: To compare long-term outcomes of weight loss and remission of obesity-related comorbidities and the prevalence of gastroesophageal reflux symptoms (GERD), endoscopic esophagitis, and Barrett esophagus (BE) after LSG and LRYGB at 10 years.

Design, Setting, And Participants: This 10-year observational follow-up evaluated patients in the Sleeve vs Bypass (SLEEVEPASS) multicenter equivalence randomized clinical trial comparing LSG and LRYGB in the treatment of severe obesity in which 240 patients aged 18 to 60 years with median body mass index of 44. Read More

Arq Bras Cir Dig 2022 17;35:e1657. Epub 2022 Jun 17.

Department of Surgery, Hospital "Dr. José J Aguirre", Faculty of Medicine, University of Chile, Santos Dumont 999, Santiago, Chile.

Aim: Laparoscopic Roux-en-Y gastric bypass (LGB) is the recommended procedure for morbidly obese patients with gastroesophageal reflux disease (GERD). However, there have been reported gastroesophageal reflux symptoms or esophagitis after LGB. Few functional esophageal studies have been reported to date. Read More

Arq Bras Cir Dig 2022 17;35:e1648. Epub 2022 Jun 17.

Cancer Institute, Hospital de Clínicas, Gastroenterology Department, Faculty of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.

Aim: Even in clinical stage IV gastric cancer (GC), surgical procedures may be required to palliate symptoms or in an attempt to improve survival. However, the limited survival of these patients raises doubts about who really had benefits from it. This study aimed to analyze the surgical outcomes in stage IV GC treated with surgical procedures without curative intent. Read More

Dig Endosc 2022 Jun 20. Epub 2022 Jun 20.

Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.

Background: Both clinical experience and supporting data have improved drastically in the context of EUS-gastrointestinal anastomosis (EUS-GIA). Where outcomes used to be questioned, focus has now moved towards performing comparative studies, optimizing technical approaches, improving patient selection and developing well-defined treatment algorithms.

Methods: The purpose of this review is to provide an overview of technical developments within EUS-GIA, discuss the current status of EUS-GIA and future directions. Read More

Obes Res Clin Pract 2022 May-Jun;16(3):249-253. Epub 2022 Jun 8.

Bariatric Unit, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK.

Background: It has been suggested that patients with a Body Mass Index (BMI) of > 60 kg/m should be offered expedited Bariatric Surgery (BS) during the Coronavirus Disease-2019 (COVID-19) pandemic. The main objective of this study was to assess the safety of this approach.

Methods: We conducted a global study of patients who underwent BS between 1/05/2020 and 31/10/2020. Read More

Asian J Surg 2022 Jun 16. Epub 2022 Jun 16.

Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital of Jilin University, Changchun City, Jilin Province, 130033, China. Electronic address:

Background: In recent years, the robot surgical system begins to be applied in single-anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S). However, only a few studies with very small sample size are present on robotic SADI-S.

Objective: This retrospective study aimed to estimate the outcomes of totally robotic SADI-S. Read More

Sci Rep 2022 Jun 18;12(1):10304. Epub 2022 Jun 18.

Department of Surgery, Minimally Invasive Surgery Research Center, Division of Minimally Invasive and Bariatric Surgery, Rasool-E Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

The most accepted procedures as conversion for poor weight changes after sleeve gastrectomy (SG), are malabsorptive surgeries. This study was designed to evaluate the 5-year outcomes of One Anastomosis Gastric Bypass (OAGB) following SG due to weight loss failure and weight regain. From September 2014 to January 2017, totally 23 patients with a history of SG conversion to OAGB in terms of weight loss failure or weight regain who had completed their 5-year follow-ups were studied. Read More

Int J Surg Case Rep 2022 Jun 8;96:107271. Epub 2022 Jun 8.

Clinique Saint Pierre, Ottignies, Belgium.

Front Endocrinol (Lausanne) 2022 30;13:896753. Epub 2022 May 30.

Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Type 2 diabetes (T2D) mellitus is a chronic inflammatory disease characterized with high secretion of tumor necrosis factor (TNF)-α, but the regulatory pathway of TNF-α production in T2D has not been fully elucidated. ASK1-interacting protein 1 (AIP1) is a signaling scaffold protein that modulates several pathways associated with inflammation. In this study, we aimed to investigate the role of AIP1 in T2D development. Read More

Front Surg 2022 31;9:916652. Epub 2022 May 31.

Division of Endocrine and Metabolic Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Laparoscopy is the surgical standard of care for bariatric procedures; however, during the last two decades, the robotic approach has gained increasing interest. It is currently considered a safe and effective alternative to laparoscopy. This literature review investigates the role of the robotic approach for primary and revisional bariatric procedures, with the particular aim of comparing this technique with the standard-of-care laparoscopic approach. Read More

Am Fam Physician 2022 Jun;105(6):593-601

Lehigh Valley Health Network, Allentown, PA, USA.

In 2019, approximately 256,000 metabolic surgery procedures were performed in the United States, a 32% increase since 2014. The most common procedures are the laparoscopic sleeve gastrectomy and the Roux-en-Y gastric bypass. Choice of procedure depends on concurrent medical conditions, patient preference, and expertise of the surgeon. Read More

Rev Esp Enferm Dig 2022 Jun 15. Epub 2022 Jun 15.

Cirugía General y del Aparato Digestivo, Hospital Universitario Torrecárdenas, España.

Streptococcus constellatus is a Gram-positive commensal bacterium of the oropharyngeal, gastrointestinal and urogenital flora. It can cause abscesses in different parts of the body, especially in immunocompromised patients. We present the clinical case of a 33-year-old female patient with a previous history of one anastomosis gastric bypass, among others. Read More

Obes Surg 2022 Jun 15. Epub 2022 Jun 15.

Min-Sheng General Hospital, Taoyuan City, Taiwan.

Purpose: One anastomosis/mini gastric bypass (OAGB/MGB) is up to date the third most performed obesity and metabolic procedure worldwide, which recently has been endorsed by ASMBS. The main criticisms are the risk of bile reflux, esophageal cancer, and malnutrition. Although IFSO has recognized this procedure, guidance is needed regarding selection criteria. Read More

J Am Coll Surg 2022 Jul 25;235(1):138-144. Epub 2022 Apr 25.

From the University of Arizona Medical Center - University Campus, Banner University Medical Center, Tucson, AZ.

Background: The main criticism of robotic surgery is longer operative time (OT). The aim of this study was to examine the variables that determine OT, the association between OT and 30-day outcomes, and the effect of the robotic approach in bariatric surgery.

Study Design: MBSAQIP data for 2016 to 2019 were queried. Read More

J Am Coll Surg 2022 Jun 8;234(6):1211-1220. Epub 2022 Apr 8.

Department of Surgery, Mayo Clinic. Rochester, MN (Badaoui, Portela, Kellogg, Ghanem).

Background: The MBSAQIP has been used to evaluate risk and create risk models. Previous studies have determined what complications matter most.

Study Design: This study was a registry-based analysis of patients who underwent laparoscopic Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) between January 1, 2015, and December 31, 2019, at centers participating in MBSAQIP. Read More

Obes Surg 2022 Jun 13. Epub 2022 Jun 13.

Department of General Surgery, Ospedale Civico Di Lugano, Via Tesserete 46, 6900, Lugano, Switzerland.

Gastrointest Endosc Clin N Am 2022 Jul 11;32(3):563-582. Epub 2022 May 11.

Department of Gastroenterology & Hepatology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Endoscopic retrograde cholangiopancreatography (ERCP) is the standard treatment of biliary disease with high success rates of greater than 90% in patients with standard anatomy. However, alterations in upper gastrointestinal anatomy can significantly complicate endoscopic biliary intervention. The past decade has seen significant advances in the endoscopic management of patients with altered anatomy. Read More

Obes Surg 2022 Jun 10. Epub 2022 Jun 10.

Gastroenterology Surgery Department, Inonu University Turgut Ozal Medical Center, Bulgurlu Mahallesi, Elazığ Yolu 15. Km, 44280, Merkez/Battalgazi/Malatya, Turkey.

Purpose: Retraction of the left lobe of the liver (LLL) is an important step in bariatric surgical procedures. A good liver retraction will both facilitate the operation and reduce complications. The aim of the study is to identify patients with large LLL with preoperative anthropometric and laboratory data, and to reveal complications due to large LLL. Read More

BMJ Open 2022 Jun 10;12(6):e061499. Epub 2022 Jun 10.

Surgery, Franciscus Gasthuis en Vlietland, Rotterdam, The Netherlands.

Introduction: Laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) are the most frequently performed procedures in bariatric surgery. In patients with morbid obesity and gastro-oesophageal reflux disease (GORD), LRYGB is the most accepted procedure. For patients with a contraindication for LRYGB or a strong preference for LSG, the Nissen-Sleeve procedure may be a viable new option. Read More

Turk J Surg 2021 Dec 31;37(4):324-335. Epub 2021 Dec 31.

Department of General Surgery, Gastrointestinal Surgery Center, Mansoura University Faculty of Medicine, Mansoura, Egypt.

Objectives: To evaluate our outcomes of laparoscopic one-anastomosis gastric bypass (LOAGB) as a primary weight loss procedure. We evaluated the impact of biliary reflux by combination of upper endoscopy (UGIE), ambulatory pH metry, and ambulatory biliary reflux monitoring.

Material And Methods: We reviewed the data of patients who underwent LOAGB during the period between July 2015 till August 2018. Read More

Obes Surg 2022 Jun 8. Epub 2022 Jun 8.

Department of General & Laparoscopic Bariatric Surgery, PRUH, King's College, London, UK.

Obes Surg 2022 Jun 8. Epub 2022 Jun 8.

Department of Surgery, King Fahd University Hospital, Imam Abdulrahman Bin Faisal University, Khobar, 34445, Saudi Arabia.

Surg Laparosc Endosc Percutan Tech 2022 May 24. Epub 2022 May 24.

School of Mathematics, Physics and Computing, Centre for Applied Climate Sciences and Centre for Health Research, University of Southern Queensland, Toowoomba.

Background: There is a paucity of data that compares the relative complication profiles of laparoscopic vertical sleeve gastrectomy (LVSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) at 5 years.

Objectives: The aim was to compare late complications of LVSG and LRYGB.

Methods: We updated our previous systematic review and meta-analysis of randomized controlled trials of primary LVSG and LRYGB procedures in adults, to review late (5 years) complication outcomes (PROSPERO 112054). Read More

J Can Assoc Gastroenterol 2022 Jun 16;5(3):116-120. Epub 2021 Sep 16.

Department of Internal Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada.

Introduction: Roux-en-Y gastric bypass (RYGB) surgery imposes anatomic barriers to endoscopic retrograde cholangiopancreatography (ERCP). Potential options for biliary access in these patients include laparoscopic-assisted ERCP or balloon enteroscopy. However, these approaches require specialized equipment and/or operating room personnel and are associated with high rates of failure and adverse events compared to conventional ERCP. Read More

Obes Surg 2022 Jun 7. Epub 2022 Jun 7.

Department of General & Laparoscopic Surgery, PRUH, King's College, London, UK.

Surg Obes Relat Dis 2022 Jul 20;18(7):983-996. Epub 2022 Apr 20.

Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.

With the prevalence of obesity alarmingly increasing, it is of primary interest to identify those factors predicting the success of anti-obesity therapeutic strategies currently adopted in clinical practice, and in particular, those of bariatric procedures showing the greatest success in terms of weight loss and maintenance in both the short and long term. Given sex-related differences in psychosocial status, hormonal homeostasis, and body fat distribution, it is likely that the response to different weight management strategies differs by sex. The objective was to elucidate the effect of sex on different bariatric procedures' efficacy and safety outcomes. Read More