A rare case of CD1a-negative Langerhans cell histiocytosis of the central nervous system in a child.
Clin Case Rep 2017 Oct 1;5(10):1664-1667. Epub 2017 Sep 1.
Cook Children's Medical CenterFort WorthTexas.
Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistry with the cell markers S100, CD1a, CD68, and Langerin [Blood, 126, 2015, 26 and N Engl J Med, 331, 1994, 154]. Read More