58,458 results match your criteria Langerhans Cell Histiocytosis


Cutaneous adult xanthogranuloma with a small portion of BRAF mutated Langerhans cell histiocytosis populations: A case report and the review of published work.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Histiocytoses, including Langerhans cell histiocytosis (LCH), juvenile or adult xanthogranuloma (AXG) and Rosai-Dorfman disease (RDD), are rare disorders characterized by the proliferation of cells derived from monocyte/macrophage lineages. A few cases of LCH coexisting with xanthogranuloma or RDD have been reported. The etiology of these diseases remains unclear. Read More

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December 2018

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

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December 2018

Preparation of Islets from Rat Pancreas and Assessment of Islet Function.

Authors:
Paul C Guest

Methods Mol Biol 2019 ;1916:223-232

Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.

The islets of Langerhans release vital hormones involved in the regulation of blood sugar and other aspects of metabolism. The islets are housed in diffuse clusters of cells within the exocrine pancreas and, therefore, purification of these cells for research or transplant purposes is a difficult undertaking. Here, a detailed protocol is presented for purification of islets from rat pancreas using limited collagenase digestion and step gradient centrifugation techniques. Read More

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January 2019

Characterization of the Goto-Kakizaki (GK) Rat Model of Type 2 Diabetes.

Authors:
Paul C Guest

Methods Mol Biol 2019 ;1916:203-211

Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.

The Goto-Kakizaki (GK) rat is a model of type 2 diabetes mellitus, produced originally by selective inbreeding for a hyperglycemic trait. These rats are characterized as having insulin resistance and an insulin secretory defect. Pancreatic islets from these mice show abnormal morphology in the distribution of glucagon-secreting α cells and insulin-secreting β cells, which may affect paracrine functions involved in the secretory response. Read More

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January 2019

Bioluminescent reporter assay for monitoring ER stress in human beta cells.

Sci Rep 2018 Dec 10;8(1):17738. Epub 2018 Dec 10.

Departments of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

During type 1 diabetes development, cells in the islets of Langerhans engage adaptive mechanisms in response to inflammatory signals to cope with stress, to restore cellular homeostasis, and to preserve cell function. Disruption of these mechanisms may induce the formation of a repertoire of stress-induced neoantigens, which are critical in the loss of tolerance to beta cells and the development of autoimmunity. While multiple lines of evidence argue for a critical role of the endoplasmic reticulum in these processes, the lack of tools to specifically monitor beta cell stress hampers the development of therapeutic interventions focusing on maintaining endoplasmic reticulum homeostasis. Read More

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December 2018

PDL2 CD11b dermal dendritic cells capture topical antigen through hair follicles to prime LAP Tregs.

Nat Commun 2018 12 7;9(1):5238. Epub 2018 Dec 7.

Pediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.

The skin immune system must discriminate between innocuous antigens and pathogens. Antigen applied topically using a Viaskin® patch elicits immune tolerance that can suppress colitis and food allergy. Here we show how topical antigen is acquired and presented by dendritic cells in the skin. Read More

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December 2018

[Current state of the problem of allotransplantation of Langerhans cells (achievements and prospects)].

Khirurgiia (Mosk) 2018 (11):80-88

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russian Federation, Moscow, Russia.

Literature data devoted to transplantation of Langerhans cells have been analyzed. The main stages, indications, dissection of islets, immunosuppressive therapy, complications and data of the latest clinical trials were discussed. Read More

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January 2018

The Molecular and Clinical Landscape of Pancreatic Neuroendocrine Tumors.

Pancreas 2019 Jan;48(1):9-21

Department of Oncology, Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

Pancreatic neuroendocrine tumors are rare tumors of the pancreas originating from the islets of the Langerhans. These tumors comprise 1% to 3% of all newly diagnosed pancreatic cancers every year and have a unique heterogeneity in clinical presentation. Whole-genome sequencing has led to an increased understanding of the molecular biology of these tumors. Read More

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January 2019

Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood.

Metabolism 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics I, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Prevalence of childhood obesity has worldwide more than doubled since 1980. Underlying factors are complex and are far from completely understood. Strategies to prevent childhood obesity have mainly focused on behavioral intervention; and obesity therapy was mainly based on lifestyle modification to date. Read More

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December 2018

Successful Treatment of Erdheim-Chester Disease With Coronary Artery Involvement.

Can J Cardiol 2018 Dec 29;34(12):1688.e9-1688.e11. Epub 2018 Sep 29.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Erdheim-Chester disease (ECD) is a rare non-Langerhans histiocytosis and inflammatory myeloid neoplasm with poor prognosis. Symmetric long bone osteosclerosis occurs in nearly all patients, but other organs are often involved. Coronary artery involvement is rare, but was encountered in a patient who experienced angina. Read More

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December 2018

A multicenter study of patients with multisystem Langerhans cell histiocytosis who develop secondary hemophagocytic lymphohistiocytosis.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized by the presence of abnormal CD1a-positive (CD1a )/CD207 histiocytes. Hemophagocytic lymphohistiocytosis (HLH) represents a spectrum of hyperinflammatory syndromes typified by the dysregulated activation of the innate and adaptive immune systems. Patients with LCH, particularly those with multisystem (MS) involvement, can develop severe hyperinflammation mimicking that observed in HLH. Read More

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December 2018
1 Read

Tri-culture system for pro-hapten sensitizer identification and potency classification.

Technology (Singap World Sci) 2018 Jun 29;6(2):67-74. Epub 2018 Jun 29.

Department of Biomedical Engineering, Rutgers, the State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA.

Allergic contact dermatitis (ACD) is an inflammatory disease that impacts 15-20% of the general population and accurate screening methods for chemical risk assessment are needed. However, most approaches poorly predict pre- and pro-hapten sensitizers, which require abiotic or metabolic conversion prior to inducing sensitization. We developed a tri-culture system comprised of MUTZ-3-derived Langerhans cells, HaCaT keratinocytes, and primary dermal fibroblasts to mimic the cellular and metabolic environments of skin sensitization. Read More

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June 2018
2 Reads

A rare case of solitary unifocal Langerhans cell histiocytosis with orbital extension: Diagnostic dilemma.

Oman J Ophthalmol 2018 Sep-Dec;11(3):284-287

Department of Ophthalmology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.

Langerhans cell histiocytosis (LCH) is rarely encountered in ophthalmology practice. It is a spectrum of disorder characterized by accumulation of histiocytes in various tissues. Diagnosis is challenging as it may simulate periorbital hematoma, rhabdomyosarcoma, and neuroblastoma. Read More

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December 2018

Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity?

Trends Immunol 2018 Nov 29. Epub 2018 Nov 29.

Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany; Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany of the German Cancer Research Center (DKFZ), Heidelberg, Germany, and of the Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany, and of the Helmholtz Association/Helmholtz Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. Electronic address:

Memory was traditionally considered an exclusive hallmark of adaptive immunity. This dogma was challenged by recent reports that myeloid cells can retain 'memory' of earlier challenges, enabling them to respond strongly to a secondary stimulus. This process, designated 'trained immunity', is initiated by modulation of precursors of myeloid cells in the bone marrow. Read More

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November 2018

Langerhans cell histiocytosis of the skull in the burr-hole site covered with hydroxyapatite material: a case report.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurosurgery, Ebina General Hospital, Kanagawa, Japan.

Background: We present a case report of a male patient with Langerhans cell histiocytosis (LCH), which occurred in a burr-hole site for chronic subdural hematoma covered with hydroxyapatite material. LCH is a rare dendritic histiocytic disorder that affects the bones, especially the skull. Until now, the association with foreign-body reaction has rarely been reported by any author. Read More

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November 2018
2 Reads

Pancreatic Progenitors: There and Back Again.

Trends Endocrinol Metab 2018 Nov 28. Epub 2018 Nov 28.

Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

Adult pancreatic regeneration is one of the most contentious topics in modern biology. The long-held view that the islets of Langerhans can be replenished throughout adult life through the reactivation of ductal progenitor cells has been replaced over the past decade by the now prevailing notion that regeneration does not involve progenitors and occurs only through the duplication of pre-existing mature cells. Here we dissect the limitations of lineage tracing (LT) to draw categorical conclusions about pancreatic regeneration, especially in view of emerging evidence that traditional lineages are less homogeneous and cell fates more dynamic than previously thought. Read More

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November 2018

Stat3 activation in epidermal keratinocytes induces Langerhans cell activation to form an essential circuit for psoriasis via IL-23 production.

J Dermatol Sci 2018 Nov 23. Epub 2018 Nov 23.

Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan.

Background: Psoriasis is an inflammatory disease associated with aberrant crosstalk between the epidermis and immune system. However, the role of Langerhans cells (LCs) in psoriasis remains controversial.

Objectives: To elucidate whether LCs are functionally involved in the development of psoriasis using a mouse model. Read More

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November 2018

Single-cell profiling reveals dendritic cell signatures associated with autoimmune inflammation.

Arthritis Rheumatol 2018 Dec 4. Epub 2018 Dec 4.

DFG-Center for Regenerative Therapies Dresden, Faculty of Medicine Carl Gustav Carus, TU, Dresden, Germany.

Objective: To identify single cell transcriptional signatures of dendritic cells (DCs) associated with autoimmunity and determine if those signatures correlate with the clinical heterogeneity of autoimmune disease.

Methods: Blood-derived DCs were single-cell sorted from patients with rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes and were analyzed using single-cell gene expression assays immediately after isolation or after in vitro stimulation. Protein expression was also measured using fluorescence activated cell sorting. Read More

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December 2018
2 Reads

Adult Langerhans' cell histiocytosis with multisystem involvement: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13366

Department of Radiology, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Republic of Korea.

Rationale: Langerhans' cell histiocytosis (LCH), also called histiocytosis X, is an uncommon disorder manifesting in a variety of ways. Although LCH can involve various organs including bone, skin, and lymph nodes, multisystem involvement of LCH is rare in adults.

Patient Concerns: A 31-year-old woman first presented to our hospital with left leg pain. Read More

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November 2018
1 Read

Hypothermic Oxygenated Machine Perfusion of the Human Donor Pancreas.

Transplant Direct 2018 Oct 7;4(10):e388. Epub 2018 Sep 7.

Departments of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Transplantation of beta cells by pancreas or islet transplantation is the treatment of choice for a selected group of patients suffering from type 1 diabetes mellitus. Pancreata are frequently not accepted for transplantation, because of the relatively high vulnerability of these organs to ischemic injury. In this study, we evaluated the effects of hypothermic machine perfusion (HMP) on the quality of human pancreas grafts. Read More

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October 2018

IL-33 Prevents MLD-STZ Induction of Diabetes and Attenuate Insulitis in Prediabetic NOD Mice.

Front Immunol 2018 15;9:2646. Epub 2018 Nov 15.

Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia.

Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of pancreatic β-cells. Prevention of type 1 diabetes requires early intervention in the autoimmune process against beta-cells of the pancreatic islets of Langerhans, which is believed to result from disordered immunoregulation. CD4Foxp3 regulatory T cells (Tregs) participate as one of the most important cell types in limiting the autoimmune process. Read More

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November 2018
2 Reads

Cutaneous Involvement of Hematologic Malignancies.

Hematol Oncol Clin North Am 2019 Feb;33(1):163-172

Lymphoma Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

In reviewing cutaneous manifestations of various hematologic malignancies, the authors focus on secondary cutaneous lymphomas and cutaneous manifestations of histiocyte disorders. Secondary cutaneous lymphomas are defined as skin lesions that develop secondary to infiltration by systemic lymphomas with predominantly extracutaneous involvement. In their review of histiocytic disorders with skin involvement, the authors focus on Langerhans cell histiocytosis and Rosai-Dorfman disease. Read More

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February 2019
1 Read

Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells.

iScience 2018 Nov 14;10:23-39. Epub 2018 Nov 14.

School of Biological Sciences, College of Science, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Republic of Singapore. Electronic address:

Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive. Here we demonstrate that Ezh2 controls cutaneous tolerance by regulating Langerhans cell (LC) transmigration across the epidermal basement membrane directly via Talin1 methylation. Ezh2 deficiency impaired disassembly of adhesion structures in LCs, leading to their defective integrin-dependent emigration from the epidermis and failure in tolerance induction. Read More

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November 2018
1 Read

Decreased plasma calcitonin gene-related peptide (CGRP) as a novel biomarker for HIV-1 disease progression.

AIDS Res Hum Retroviruses 2018 Nov 29. Epub 2018 Nov 29.

Institut Cochin, 55648, Infection, Immunity and Inflammation , 22 rue Mechian , Paris, France , 75014 ;

HIV-1 mucosal transmission in genital epithelia occurs via infection of Langerhans cells (LCs) and subsequent trans-infection of CD4+ T-cells. We previously reported that the vasodilator neuropeptide calcitonin gene-related peptide (CGRP), secreted upon activation of sensory peripheral neurons that innervate all mucosal epithelia, significantly inhibits trans-infection. To investigate the association between CGRP and HIV-1 during infection, we evaluated circulating CGRP levels in HIV-1-infected patients. Read More

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November 2018

[A case of Langerhans cell histiocytosis of the liver in adults with abdominal pain as the initial manifestation].

Authors:
L X Liu S M Wang

Zhonghua Gan Zang Bing Za Zhi 2018 Sep;26(9):702-704

Department of Infectious Diseases, Lishui People's Hospital, Lishui 323000, China.

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September 2018
1 Read

Redefining the signaling pathways from pluripotency to pancreas development: In vitro β-cell differentiation.

J Cell Physiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Anatomy and Embryology, Faculty of Medicine, Joundishapur University of Medical Sciences, Ahvaz, Iran.

Pancreatic β-cells are destroyed by the immune system, in type 1 diabetes (T1D) and are impaired by glucose insensitivity in type 2 diabetes (T2D). Islet-cells transplantation is a promising therapeutic approach based on in vitro differentiation of pluripotent stem cells (PSCs) to insulin-producing cells (IPCs). According to evolutionary stages in β-cell development, there are several distinct checkpoints; each one has a unique characteristic, including definitive endoderm (DE), primitive gut (PG), posterior foregut (PF), pancreatic epithelium (PE), endocrine precursor (EP), and immature β-cells up to functional β-cells. Read More

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November 2018
1 Read

General features of patients with Pulmonary Langerhans Cell Histiocytosis followed in our instution.

Tuberk Toraks 2018 Sep;66(3):205-211

Clinic of Chest Diseases, Istanbul Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey.

Introduction: Pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare disease affecting young smokers. It is more common between the ages of 20-40 and equals the male/female ratio. Lung biopsy is the most useful methods for diagnosis. Read More

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September 2018
2 Reads

Author Correction: Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans.

Sci Rep 2018 Nov 27;8(1):17472. Epub 2018 Nov 27.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, via Trentacoste 2, 20134, Milan, Italy.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. Read More

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November 2018
3 Reads

Content-aware image restoration: pushing the limits of fluorescence microscopy.

Nat Methods 2018 Dec 26;15(12):1090-1097. Epub 2018 Nov 26.

Center for Systems Biology Dresden, Dresden, Germany.

Fluorescence microscopy is a key driver of discoveries in the life sciences, with observable phenomena being limited by the optics of the microscope, the chemistry of the fluorophores, and the maximum photon exposure tolerated by the sample. These limits necessitate trade-offs between imaging speed, spatial resolution, light exposure, and imaging depth. In this work we show how content-aware image restoration based on deep learning extends the range of biological phenomena observable by microscopy. Read More

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December 2018

Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain.

J Pineal Res 2018 Nov 26:e12540. Epub 2018 Nov 26.

Inserm, U1016, Institut Cochin, Paris, France.

Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non-24h sleep-wake disorders and major depressive disorders. In mammals, two melatonin receptors (MTRs) exist, MT and MT , belonging to the G protein-coupled receptor (GPCR) super-family. Read More

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November 2018
1 Read

Longitudinal assessment of peripheral blood BRAFV600E levels in patients with Langerhans cell histiocytosis.

Pediatr Res 2018 Nov 24. Epub 2018 Nov 24.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.

Background: Langerhans cell histiocytosis (LCH) is a histiocytic disorder driven by a constitutive activation of the MAPK signaling pathway in myeloid cells. In 50-60% of cases, it is caused by the BRAFV600E mutation. There is evidence that levels of BRAFV600E in the peripheral blood of patients with LCH correlate with disease burden and could be used as marker for disease extent and response to therapy. Read More

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November 2018

Erdheim Chester disease in a patient with Burkitt lymphoma: a case report and review of literature.

Diagn Pathol 2018 Nov 24;13(1):94. Epub 2018 Nov 24.

Department of Pathology, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, N#308, Columbus, OH, 43210, USA.

Background: Erdheim Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by widespread tissue infiltration by CD68-positive, CD1a-negative foamy histiocytes. ECD can be difficult to identify, and diagnosis relies on the presence of histiocytes with certain histologic and immunophenotypic features in an appropriate clinical and radiologic setting. Clinical signs and symptoms are variable depending on which organ systems are involved. Read More

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November 2018
2 Reads

A complex auxiliary: IL-17/Th17 signaling during type 1 diabetes progression.

Mol Immunol 2018 Nov 22;105:16-31. Epub 2018 Nov 22.

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning Province, PR China. Electronic address:

Type 1 diabetes (T1D) is an autoimmune disease centered around the loss of the beta cells of the islets of Langerhans, and consequent inability of the islets to produce the insulin necessary to maintain glycemic control. While most therapeutic approaches have been centered on insulin replacement, newer approaches to target the underlying immune response have become an area of focus. However, the immune landscape in T1D is extremely complex, and the roles played by individual cytokines during disease progression are incompletely understood, making the development of immunotherapies very difficult. Read More

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November 2018
2 Reads

Langerhans cell histiocytosis: a rare case of large-bowel inflammatory lesions.

Endoscopy 2018 Nov 23. Epub 2018 Nov 23.

Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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November 2018
1 Read

Anti TNF-α therapy in patients with relapsed and refractory Langerhans cell histiocytosis: a phase II study.

Pediatr Hematol Oncol 2018 Nov 23:1-7. Epub 2018 Nov 23.

a Texas Children's Cancer and Hematology Centers, Baylor College of Medicine , Houston , TX , USA.

Tumor necrosis factor alpha (TNF-α) is produced in Langerhans cell histiocytosis (LCH) lesions and is elevated in plasma of patients with active LCH. It has been postulated that TNF-α may play a role in the pathophysiology of LCH. Etanercept, an anti-TNF-α antibody, has been used in TNF-modulated diseases such as rheumatoid arthritis (RA). Read More

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November 2018
3 Reads

Aggregation of the diabetes-related peptide ProIAPP measured by dynamic light scattering.

J Trace Elem Med Biol 2019 Jan 10;51:1-8. Epub 2018 Sep 10.

The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK. Electronic address:

Islet amyloid polypeptide (IAPP) or amylin is implicated in the aetiology of diabetes. It is found as amyloid along with its precursor ProIAPP in the islets of Langerhans in the pancreas. Metals have been implicated in amyloidogenesis of both IAPP and ProIAPP. Read More

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January 2019
3 Reads

Leea macrophylla root extract upregulates the mRNA expression for antioxidative enzymes and repairs the necrosis of pancreatic β-cell and kidney tissues in fructose-fed Type 2 diabetic rats.

Biomed Pharmacother 2018 Nov 19;110:74-84. Epub 2018 Nov 19.

Designated Reference Institute for Chemical Measurements (DRiCM), Bangladesh Council of Scientific & Industrial Research (BCSIR), Dr. Qudrat-i-Khuda Road, Dhanmondi, Dhaka, 1205, Bangladesh.

This research investigated the functional food effect of Leea macrophylla (Roxb.) ex Hornem root extract on pancreatic necrosis in Streptozotocin-induced type-2 diabetes. Prior to animal intervention, Leea macrophylla root extract (LMR) was subjected to GC-MS analysis. Read More

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November 2018
4 Reads
2.023 Impact Factor

Machine learning based classification of cells into chronological stages using single-cell transcriptomics.

Sci Rep 2018 Nov 21;8(1):17156. Epub 2018 Nov 21.

MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK.

Age-associated deterioration of cellular physiology leads to pathological conditions. The ability to detect premature aging could provide a window for preventive therapies against age-related diseases. However, the techniques for determining cellular age are limited, as they rely on a limited set of histological markers and lack predictive power. Read More

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November 2018
2 Reads

DEL-1 promotes macrophage efferocytosis and clearance of inflammation.

Nat Immunol 2018 Nov 19. Epub 2018 Nov 19.

Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Resolution of inflammation is essential for tissue homeostasis and represents a promising approach to inflammatory disorders. Here we found that developmental endothelial locus-1 (DEL-1), a secreted protein that inhibits leukocyte-endothelial adhesion and inflammation initiation, also functions as a non-redundant downstream effector in inflammation clearance. In human and mouse periodontitis, waning of inflammation was correlated with DEL-1 upregulation, whereas resolution of experimental periodontitis failed in DEL-1 deficiency. Read More

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November 2018
5 Reads

Enlargement of Langerhans cell histiocytosis of the hypothalamus with progression into the basal ganglia and white matter.

Surg Neurol Int 2018 3;9:197. Epub 2018 Oct 3.

Department of Neurosurgery, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.

Background: Langerhans cell histiocytosis (LCH) is a rare disease that may affect the central nervous system; it is caused by dendritic cell proliferation, and typically occurs in children. LCH frequently appears in the pituitary stalk and rarely results in multiple enhanced lesions in the brain parenchyma.

Case Description: We present a case of a 40-year-old woman who deveolped panhypopituitarism and central diabetes insipidus in the postpartum period requiring hormone replacement therapy. Read More

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October 2018
3 Reads

Epidermal barrier function is impaired in Langerhans cell-depleted mice.

J Invest Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Department of Dermatology, Severance Hospital, Cutaneous biology Institute, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

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November 2018
1 Read

Low levels of alpha-synuclein in peripheral tissues are related to clinical relapse in relapsing-remitting multiple sclerosis: a pilot cross-sectional study.

J Neurol Sci 2018 Nov 3;396:87-93. Epub 2018 Nov 3.

Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico. Electronic address:

The protein alpha-synuclein (α-Syn) has been linked to neuroinflammatory conditions. We investigated whether the presence of α-Syn in peripheral tissues is a surrogate of brain inflammatory status in a small group of relapsing-remitting multiple sclerosis (RRMS) patients in a pilot cross-sectional study. Skin biopsies and peripheral blood were sampled from 34 healthy controls and 23 MS patients for measurement of α-Syn levels. Read More

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November 2018
3 Reads

Multidisciplinary rehabilitation of eosinophilic granuloma with bone graft surgery and a modified implant-supported hybrid prosthesis: A case report with a 6-year follow-up.

Spec Care Dentist 2018 Nov 15. Epub 2018 Nov 15.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.

Eosinophilic granuloma is the most common form of Langerhans cell histiocytosis and corresponds with bone lesions characterized by pain, rapid growth, and high tendency of recurrence after inadequate curettage. It is a rare disease that is difficult to diagnose clinically and radiographically because it mimics other odontogenic cysts and tumors. In this report, the reconstruction of an osseous defect with an iliac graft and a modified implant-supported hybrid prosthesis after surgical excision of an eosinophilic granuloma in the mandible of a 27-year-old male patient was described. Read More

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November 2018
5 Reads

BRAF V600E expression in juvenile xanthogranuloma occurring after Langerhans cell histiocytosis.

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Histiocytosis are a heterogenous group of diseases resulting from the abnormal proliferation of cells derived from macrophages-monocytes or dendritic cells at various sites, including bones, soft tissues and skin. Histiocytosis comprises the Langerhans group (L group), including Langerhans cell histiocytosis (LCH), the cutaneous and mucocutaneous histiocytosis (C group), comprising juvenile xanthogranuloma (JXG) and the group of Rosai-Dorfman disease and related-histioctytosis (R group). JXG is the most common form of non-Langerhans cell histiocytosis (nLCH), and generally is self-limiting and non-aggressive. Read More

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November 2018
7 Reads

Possible Prevention of Diabetes with a Gluten-Free Diet.

Nutrients 2018 Nov 13;10(11). Epub 2018 Nov 13.

The Bartholin Institute, Ole Maaløes Vej 5, Rigshospitalet, 2200 Copenhagen, Denmark.

Gluten seems a potentially important determinant in type 1 diabetes (T1D) and type 2 diabetes (T2D). Intake of gluten, a major component of wheat, rye, and barley, affects the microbiota and increases the intestinal permeability. Moreover, studies have demonstrated that gluten peptides, after crossing the intestinal barrier, lead to a more inflammatory milieu. Read More

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November 2018
3 Reads

Spontaneous resolution of unifocal Langerhans cell histiocytosis of the skull: potential role of ultrasound in detection and imaging follow-up.

J Ultrason 2018 ;18(74):265-270

Department of Neurosurgery, Antwerp University Hospital and Antwerp University, Edegem, Belgium.

Langerhans cell histiocytosis is a tumor-like condition characterized by idiopathic proliferation of Langerhans cells. The disease may involve the skeleton as well as other organs systems. Bone involvement may be solitary or multifocal. Read More

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January 2018
5 Reads

Langerhans cell histiocytosis.

Indian J Med Res 2018 Sep;148(3):351-352

Department of Endocrinology, Command Hospital, Lucknow 226 002, India.

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September 2018

Method for isolation of pancreatic blood vessels, their culture and coculture with islets of langerhans.

Biotechnol Prog 2018 Nov 13. Epub 2018 Nov 13.

Laboratoire de bio-ingénierie et de biophysique de l'Université de Sherbrooke, Dept. of Chemical and Biotechnological Engineering, Université de Sherbrooke, Québec, J1K 2R1, Canada.

The only cure available for Type 1 diabetes involves the transplantation of islets of Langerhans isolated from donor organs. However, success rates are relatively low. Disconnection from vasculature upon isolation and insufficient rate of revascularization upon transplantation are thought to be a major cause, as islet survival and function depend on extensive vascularization. Read More

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November 2018
4 Reads