159,082 results match your criteria Lancet[Journal]


Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial.

Lancet 2018 Dec 10. Epub 2018 Dec 10.

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Background: Maintenance therapy following autologous stem cell transplantation (ASCT) can delay disease progression and prolong survival in patients with multiple myeloma. Ixazomib is ideally suited for maintenance therapy given its convenient once-weekly oral dosing and low toxicity profile. In this study, we aimed to determine the safety and efficacy of ixazomib as maintenance therapy following ASCT. Read More

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December 2018

What is an appropriate level of evidence for a digital health intervention?

Lancet 2018 Dec 7. Epub 2018 Dec 7.

National Institute for Health and Care Excellence, London, UK; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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December 2018

Oral proteasome inhibitor maintenance for multiple myeloma.

Lancet 2018 Dec 10. Epub 2018 Dec 10.

Department of Haematology, University College London, London, UK.

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December 2018

Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study.

Lancet Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: Survival from colorectal cancer has been shown to be lower in Denmark and England than in comparable high-income countries. We used data from national colorectal cancer registries to assess whether differences in the proportion of patients receiving resectional surgery could contribute to international differences in colorectal cancer survival.

Methods: In this population-based study, we collected data from all patients aged 18-99 years diagnosed with primary, invasive, colorectal adenocarcinoma from Jan 1, 2010, to Dec 31, 2012, in Denmark, England, Norway, and Sweden, from national colorectal cancer registries. Read More

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December 2018

The importance of surgery in colorectal cancer treatment.

Authors:
Eva Angenete

Lancet Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital/Östra, Scandinavian Surgical Outcomes Research Group, 413 45 Gothenburg, Sweden. Electronic address:

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December 2018

Correction to Lancet Infect Dis 2018; 18: 1097-107.

Authors:

Lancet Infect Dis 2018 Dec 10. Epub 2018 Dec 10.

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December 2018

10-day decitabine schedule in acute myeloid leukaemia: no extra bang for the buck.

Authors:
Amanda F Cashen

Lancet Haematol 2018 Dec 10. Epub 2018 Dec 10.

Section of Bone Marrow Trasnplant and Leukemia, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address:

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December 2018

Treatment with a 5-day versus a 10-day schedule of decitabine in older patients with newly diagnosed acute myeloid leukaemia: a randomised phase 2 trial.

Lancet Haematol 2018 Dec 10. Epub 2018 Dec 10.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Hypomethylating agents, such as decitabine, are the standard of care for older patients with newly diagnosed acute myeloid leukaemia. Single-arm studies have suggested that a 10-day schedule of decitabine cycles leads to better outcomes than the usual 5-day schedule. We compared the efficacy and safety of these two schedules. Read More

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December 2018

The right to health.

Authors:
The Lancet

Lancet 2018 Dec 7. Epub 2018 Dec 7.

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December 2018

Strategies not accompanied by a mental health professional to address anxiety and depression in children and young people: a scoping review of range and a systematic review of effectiveness.

Lancet Psychiatry 2018 Dec 3. Epub 2018 Dec 3.

MindMonkey Associates, London, UK.

This Review reports on a scoping review followed by a systematic review to consider interventions designed to address or manage depression or anxiety in children and young people up to the age of 25 years without the need to involve mental health professionals. The scoping review identified 132 approaches, 103 of which referred to children or young people (younger than 25 years). These approaches included social interaction, engagement with nature, relaxation, distraction, sensory stimulation, physical activity, altering perceptions, engaging in hobbies, self-expression, and exploration. Read More

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December 2018
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Factors affecting implementation of digital health interventions for people with psychosis or bipolar disorder, and their family and friends: a systematic review.

Lancet Psychiatry 2018 Dec 3. Epub 2018 Dec 3.

Faculty of Health and Medicine, Furness College, Lancaster University, Lancaster, UK.

Digital health interventions present an important opportunity to improve health care for people with psychosis or bipolar disorder, but despite their potential, integrating and implementing them into clinical settings has been difficult worldwide. This Review aims to identify factors affecting implementation of digital health interventions for people affected by psychosis or bipolar disorder. We searched seven databases and synthesised data from 26 studies using the Consolidated Framework for Implementation Research. Read More

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December 2018

Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial.

Lancet Oncol 2018 Nov 30. Epub 2018 Nov 30.

Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN, USA.

Background: Both single-agent ibrutinib and chlorambucil plus obinutuzumab have shown superior efficacy to chlorambucil monotherapy and are standard first-line treatments in chronic lymphocytic leukaemia. We compared the efficacy of the combination of ibrutinib plus obinutuzumab with chlorambucil plus obinutuzumab in first-line chronic lymphocytic leukaemia or small lymphocytic lymphoma.

Methods: iLLUMINATE is a multicentre, randomised, open-label, phase 3 trial done at 74 academic and community hospitals in Australia, Canada, Israel, New Zealand, Russia, Turkey, the EU, and the USA in patients with previously untreated chronic lymphocytic leukaemia or small lymphocytic lymphoma, either aged 65 years or older or younger than 65 years with coexisting conditions. Read More

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November 2018

Drug development for glioma: are we repeating the same mistakes?

Authors:
Roger Stupp

Lancet Oncol 2018 Dec 3. Epub 2018 Dec 3.

Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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December 2018

Regorafenib compared with lomustine in patients with relapsed glioblastoma (REGOMA): a multicentre, open-label, randomised, controlled, phase 2 trial.

Lancet Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. Electronic address:

Background: Glioblastoma is a highly vascularised tumour and there are few treatment options after disease recurrence. Regorafenib is an oral multikinase inhibitor of angiogenic, stromal, and oncogenic receptor tyrosine kinases. We aimed to assess the efficacy and safety of regorafenib in the treatment of recurrent glioblastoma. Read More

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December 2018

Ibrutinib: searching for a partner drug.

Lancet Oncol 2018 Nov 30. Epub 2018 Nov 30.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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November 2018

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.

Lancet 2018 Dec 3. Epub 2018 Dec 3.

Universitätsmedizin Göttingen, Göttingen, Germany.

Background: Based on the encouraging activity and manageable safety profile observed in a phase 1 study, the ECHELON-2 trial was initiated to compare the efficacy and safety of brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (A+CHP) versus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) for the treatment of CD30-positive peripheral T-cell lymphomas.

Methods: ECHELON-2 is a double-blind, double-dummy, randomised, placebo-controlled, active-comparator phase 3 study. Eligible adults from 132 sites in 17 countries with previously untreated CD30-positive peripheral T-cell lymphomas (targeting 75% with systemic anaplastic large cell lymphoma) were randomly assigned 1:1 to receive either A+CHP or CHOP for six or eight 21-day cycles. Read More

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December 2018

Chinese Academy of Engineering calls for actions on the birth of gene-edited infants.

Lancet 2018 Dec 3. Epub 2018 Dec 3.

Chinese Academy of Engineering, Beijing 100088, China. Electronic address:

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December 2018

Confronting the most challenging risk factor: non-adherence.

Lancet 2018 Dec 3. Epub 2018 Dec 3.

Cardiocentro Ernesto Che Guevara, Villa Clara, Cuba.

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December 2018

Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA): a pragmatic, open-label, randomised controlled trial.

Lancet 2018 Dec 3. Epub 2018 Dec 3.

Unit of Epidemiology and Global Health, Umeå University, Umeå, Sweden.

Background: Primary prevention of cardiovascular disease often fails because of poor adherence among practitioners and individuals to prevention guidelines. We aimed to investigate whether ultrasound-based pictorial information about subclinical carotid atherosclerosis, targeting both primary care physicians and individuals, improves prevention.

Methods: Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA) is a pragmatic, open-label, randomised controlled trial that was integrated within the Västerbotten Intervention Programme, an ongoing population-based cardiovascular disease prevention programme in northern Sweden. Read More

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December 2018
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Gene-edited babies: Chinese Academy of Medical Sciences' response and action.

Lancet 2018 Dec 3. Epub 2018 Dec 3.

Chinese Academy of Medical Sciences, Beijing 100730, China.

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December 2018

Be AWaRe: new metrics for paediatric antibiotic stewardship.

Lancet Infect Dis 2018 Dec 3. Epub 2018 Dec 3.

Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa.

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December 2018

Consumption of oral antibiotic formulations for young children according to the WHO Access, Watch, Reserve (AWaRe) antibiotic groups: an analysis of sales data from 70 middle-income and high-income countries.

Lancet Infect Dis 2018 Dec 3. Epub 2018 Dec 3.

Paediatric Infectious Diseases Research Group, Institute of Infection and Immunity, St George's University of London, London, UK; Paediatric Pharmacology and Paediatric Infectious Diseases, University of Basel Children's Hospital, Basel, Switzerland. Electronic address:

Background: The 2017 WHO Model List of Essential Medicines for Children (EMLc) groups antibiotics as Access, Watch, or Reserve, based on recommendations of their use as first-choice and second-choice empirical treatment for the most common infections. This grouping provides an opportunity to review country-level antibiotic consumption and a potential for stewardship. Therefore, we aimed to review 2015 levels of oral antibiotic consumption by young children globally. Read More

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December 2018

Consideration of local geographical variations in PM concentrations in China - Authors' reply.

Lancet Public Health 2018 Dec;3(12):e565

National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.

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December 2018

Consideration of local geographical variations in PM concentrations in China.

Authors:
Haris Majeed

Lancet Public Health 2018 Dec;3(12):e564

Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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December 2018

Language disintegration: communication ability in elderly immigrants with dementia.

Lancet Public Health 2018 Dec;3(12):e563

VID Specialized University, Oslo, Norway.

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December 2018

The future of the sweetened beverages tax in Portugal.

Lancet Public Health 2018 Dec;3(12):e562

Faculty of Medicine, Porto University, Porto, Portugal.

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December 2018

Acute respiratory failure in immunocompromised adults.

Lancet Respir Med 2018 Dec 7. Epub 2018 Dec 7.

Assistance Publique Hôpitaux de Paris, Service de Médecine Intensive et Réanimation, Hôpital Saint-Louis, Paris, France; ECSTRA Team, Biostatistics and Clinical Epidemiology, Center of Epidemiology and Biostatistics Sorbonne Paris Cité, Institut national de la santé et de la recherche médicale, Paris Diderot Sorbonne University, Paris, France.

Acute respiratory failure occurs in up to half of patients with haematological malignancies and 15% of those with solid tumours or solid organ transplantation. Mortality remains high. Factors associated with mortality include a need for invasive mechanical ventilation, organ dysfunction, older age, frailty or poor performance status, delayed intensive care unit admission, and acute respiratory failure due to an invasive fungal infection or unknown cause. Read More

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December 2018

Maternal immunisation to improve the health of HIV-exposed infants.

Lancet Infect Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.

HIV-exposed but uninfected (HEU) infants are at an increased risk of many infectious diseases that can contribute to the high mortality seen among HEU children. Maternal immunisation could be a promising strategy to reduce infections in HEU infants. However, very little research has explored the effect of HIV on the immunogenicity and effectiveness of vaccines given during pregnancy. Read More

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December 2018

Treating young children co-infected with tuberculosis and HIV.

Lancet HIV 2018 Dec 6. Epub 2018 Dec 6.

MRC Clinical Trials Unit at University College London, Institute of Clinical Trials & Methodology, London WC1V 6LJ, UK; Department of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; University College London Great Ormond Street Institute of Child Health, London, UK.

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December 2018

Lopinavir-ritonavir super-boosting in young HIV-infected children on rifampicin-based tuberculosis therapy compared with lopinavir-ritonavir without rifampicin: a pharmacokinetic modelling and clinical study.

Lancet HIV 2018 Dec 6. Epub 2018 Dec 6.

Drugs for Neglected Diseases Initiative, Geneva, Switzerland.

Background: Rifampicin reduces lopinavir concentrations in HIV and tuberculosis co-treated patients. We hypothesised that adding ritonavir to co-formulated lopinavir-ritonavir (4:1) to achieve a one-to-one ratio would overcome this drug-drug interaction in young children.

Methods: We did a prospective, open-label, one-group, one-sequence study at five sites in three South African provinces. Read More

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December 2018
1 Read

Reviewing the Mental Health Act: delivering evidence-informed policy.

Lancet Psychiatry 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychiatry, Faculty of Brain Sciences, University College London, London, UK.

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December 2018

The impact of air pollution on deaths, disease burden, and life expectancy across the states of India: the Global Burden of Disease Study 2017.

Authors:

Lancet Planet Health 2018 Dec 5. Epub 2018 Dec 5.

Background: Air pollution is a major planetary health risk, with India estimated to have some of the worst levels globally. To inform action at subnational levels in India, we estimated the exposure to air pollution and its impact on deaths, disease burden, and life expectancy in every state of India in 2017.

Methods: We estimated exposure to air pollution, including ambient particulate matter pollution, defined as the annual average gridded concentration of PM, and household air pollution, defined as percentage of households using solid cooking fuels and the corresponding exposure to PM, across the states of India using accessible data from multiple sources as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017. Read More

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December 2018

Mind the brain: the psychiatry of childhood seizures.

Authors:
Max Wiznitzer

Lancet Child Adolesc Health 2018 Dec 6. Epub 2018 Dec 6.

Division of Pediatric Neurology, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

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December 2018

Childhood seizures and risk of psychiatric disorders in adolescence and early adulthood: a Danish nationwide cohort study.

Lancet Child Adolesc Health 2018 Dec 6. Epub 2018 Dec 6.

National Center for Register-Based Research, Aarhus University, Aarhus, Denmark; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.

Background: Paediatric seizures have been linked to psychiatric disorders in childhood, but there is a paucity of large-scale population-based studies of psychiatric comorbidity in later life. We aimed to examine the relation between childhood seizures and the risk of psychiatric disorders in adolescence and early adulthood.

Methods: We did a register-based cohort study of all individuals born in Denmark in 1978-2002. Read More

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December 2018

Criminalising sexuality or preventing child marriage: legal interventions and girls' empowerment.

Lancet Child Adolesc Health 2018 Dec 5. Epub 2018 Dec 5.

Columbia University Mailman School of Public Health, Columbia University, New York, NY 10032, USA.

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December 2018

Children and adolescents on the move: what does the Global Compact for Migration mean for their health?

Lancet Child Adolesc Health 2018 Dec 5. Epub 2018 Dec 5.

Institute for Global Health, University College London, London WC1N 1EH.

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December 2018

Protection versus rights: age of marriage versus age of sexual consent.

Lancet Child Adolesc Health 2018 Dec 5. Epub 2018 Dec 5.

Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia; Centre for Adolescent Health, Murdoch Children's Research Institute and Royal Children's Hospital, Melbourne, VIC, Australia.

As many governments worldwide have raised the legal age of marriage to 18 years, some are also considering raising the age of sexual consent. Without close-in-age exemptions, arguments to align the legal age of sexual consent with that of marriage would restrict the ability of adolescents to legally have sex. In contrast to international agreements that affirm 18 years as the minimum age for consent to marriage, international human-rights standards do not recommend specific age limits for sexual consent but urge recognition of adolescents as rights holders, including rights in relation to sexuality. Read More

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December 2018

Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial.

Lancet Psychiatry 2018 Dec 6. Epub 2018 Dec 6.

Schizophrenia and Neuropharmacology Research Group, VA Connecticut Healthcare System, West Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Background: Cannabis is one of the most widely used drugs worldwide. Cannabis use disorder is characterised by recurrent use of cannabis that causes significant clinical and functional impairment. There are no approved pharmacological treatments for cannabis use disorder. Read More

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December 2018
3 Reads

FAAH inhibition for treatment of problematic cannabis use.

Authors:
Tony P George

Lancet Psychiatry 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry, University of Toronto and Centre for Addiction and Mental Health (CAMH), Toronto, ON M6J 1H4, Canada. Electronic address:

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December 2018
1 Read

Modernising the Mental Health Act: getting the balance right.

Lancet 2018 Dec 7. Epub 2018 Dec 7.

Belfast Health and Social Care Trust, Belfast, UK.

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December 2018

2018 American Society of Hematology Annual Meeting.

Authors:
Katherine Gourd

Lancet Oncol 2018 Dec 6. Epub 2018 Dec 6.

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December 2018

Considering chronic uncertainty among Syrian refugees resettling in Europe.

Lancet Public Health 2018 Dec 5. Epub 2018 Dec 5.

Department of Epidemiology and Population Health, American University of Beirut, Beirut, Lebanon; Center for Immigrant, Refugee and Global Health, City University of New York School of Public Health, New York, NY, USA.

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December 2018

Urgency for South Africa to prioritise cardiovascular disease management.

Authors:
Aletta E Schutte

Lancet Glob Health 2018 Dec 6. Epub 2018 Dec 6.

Hypertension in Africa Research Team, South African Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom 2520, South Africa. Electronic address:

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December 2018

Implications of scaling up cardiovascular disease treatment in South Africa: a microsimulation and cost-effectiveness analysis.

Lancet Glob Health 2018 Dec 6. Epub 2018 Dec 6.

MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Institute for Applied Health Research, Birmingham University, Birmingham, UK.

Background: Cardiovascular diseases and their risk factors-particularly hypertension, dyslipidaemia, and diabetes-have become an increasing concern for middle-income countries. Using newly available, nationally representative data, we assessed how cardiovascular risk factors are distributed across subpopulations within South Africa and identified which cardiovascular treatments should be prioritised.

Methods: We created a demographically representative simulated population for South Africa and used data from 17 743 respondents aged 15 years or older of the 2012 South African National Health and Nutrition Examination Survey (SANHANES) to assign information on cardiovascular risk factors to each member of the simulated population. Read More

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December 2018

Fluoxetine and recovery after stroke.

Lancet 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands. Electronic address:

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December 2018

Global patterns of mortality in international migrants: a systematic review and meta-analysis.

Lancet 2018 Dec 5. Epub 2018 Dec 5.

Institute for Global Health, University College London, London, UK.

Background: 258 million people reside outside their country of birth; however, to date no global systematic reviews or meta-analyses of mortality data for these international migrants have been done. We aimed to review and synthesise available mortality data on international migrants.

Methods: In this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Library, and Google Scholar databases for observational studies, systematic reviews, and randomised controlled trials published between Jan 1, 2001, and March 31, 2017, without language restrictions. Read More

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December 2018