160,856 results match your criteria Lancet[Journal]


An ethics framework and practical guidance for post-trial access to an RSV maternal vaccine.

Lancet Respir Med 2019 Apr 16. Epub 2019 Apr 16.

Departments of Global Health and Epidemiology, Rollins School of Public Health, and Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1016/S2213-2600(19)30080-3DOI Listing
April 2019
1 Read

Tuberculosis in diabetes: insidious and neglected.

Authors:
Ammara Mushtaq

Lancet Respir Med 2019 Apr 16. Epub 2019 Apr 16.

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http://dx.doi.org/10.1016/S2213-2600(19)30119-5DOI Listing

The effect of emicizumab regimen on haemophilia outcomes.

Authors:
Margaret V Ragni

Lancet Haematol 2019 Apr 16. Epub 2019 Apr 16.

University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Hemophilia Center of Western Pennsylvania, Pittsburgh PA 15213-4306, USA. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(19)30070-5DOI Listing

Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study.

Lancet Haematol 2019 Apr 16. Epub 2019 Apr 16.

Hospital Universitario La Paz, Autónoma University, Madrid, Spain.

Background: Emicizumab, a subcutaneously administered, humanised, bispecific, monoclonal antibody, is approved to treat people with haemophilia A of all ages with and without coagulation factor VIII (FVIII) inhibitors. HAVEN 4 assessed emicizumab prophylaxis administered as one dose every 4 weeks in adults and adolescents with haemophilia A, regardless of FVIII inhibitor status.

Methods: In this phase 3, multicentre, open-label, two-stage study, patients aged 12 years and older with severe congenital haemophilia A (<1% of normal FVIII activity in blood) or haemophilia A with FVIII inhibitors, undergoing treatment with either FVIII concentrates or bypassing agents were recruited from three sites in Japan and Spain for a run-in cohort, and from 17 sites in Australia, Belgium, Japan, Poland, Spain, and the USA for a subsequent expansion cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523026193005
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http://dx.doi.org/10.1016/S2352-3026(19)30054-7DOI Listing
April 2019
1 Read

Dilation after small biliary sphincterotomy.

Lancet Gastroenterol Hepatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology Hepatopancreatology and Digestive Oncology, Erasme University Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(19)30121-9DOI Listing

Optimal dilation time for combined small endoscopic sphincterotomy and balloon dilation for common bile duct stones: a multicentre, single-blinded, randomised controlled trial.

Lancet Gastroenterol Hepatol 2019 Apr 16. Epub 2019 Apr 16.

Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China; Hepatopancreatobiliary Surgery Institute of Gansu Province, Clinical Medical College Cancer Center of Lanzhou University, Lanzhou, China; Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province, Lanzhou, China. Electronic address:

Background: Endoscopic sphincterotomy is the established treatment for common bile duct stones. Balloon dilation offers an alternative. Prolonged dilation (300 s) with a 10 mm diameter balloon decreases the occurrence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Read More

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http://dx.doi.org/10.1016/S2468-1253(19)30075-5DOI Listing

MEK and PD-L1 inhibition in colorectal cancer: a burning blaze turning into a flash in the pan.

Lancet Oncol 2019 Apr 16. Epub 2019 Apr 16.

Gastrointestinal Unit, Department of Medical Oncology, Institut Jules Bordet, Brussels 1000, Belgium; Université Libre de Bruxelles, Brussels, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045193007
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http://dx.doi.org/10.1016/S1470-2045(19)30076-2DOI Listing
April 2019
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Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial.

Lancet Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy. Electronic address:

Background: Microsatellite-stable metastatic colorectal cancer is typically unresponsive to immunotherapy. This phase 3 study was designed to assess atezolizumab plus cobimetinib in metastatic colorectal cancer. Here, we report the comparison of atezolizumab plus cobimetinib or atezolizumab monotherapy versus regorafenib in the third-line setting. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30027-0DOI Listing

Building the momentum and blueprint for reform in youth mental health.

Authors:
Patrick McGorry

Lancet Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Parkville VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/S2215-0366(19)30050-1DOI Listing

Encephalitis-spreading the word.

Authors:
Jules Morgan

Lancet Neurol 2019 Apr 16. Epub 2019 Apr 16.

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http://dx.doi.org/10.1016/S1474-4422(19)30155-3DOI Listing

Therapeutic interventions in patients with prolonged disorders of consciousness.

Lancet Neurol 2019 Apr 16. Epub 2019 Apr 16.

Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium.

The management of patients with severe brain injuries and prolonged disorders of consciousness raises important issues particularly with respect to their therapeutic options. The scarcity of treatment options is challenged by new clinical and neuroimaging data indicating that some patients with prolonged disorders of consciousness might benefit from therapeutic interventions, even years after the injury. Most studies of interventions aimed at improving patients' level of consciousness and functional recovery were behavioural and brain imaging open-label trials and case reports, but several randomised controlled trials have been done, particularly focused on the effects of drugs or use of non-invasive brain stimulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14744422193003
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http://dx.doi.org/10.1016/S1474-4422(19)30031-6DOI Listing
April 2019
1 Read

Correction to Lancet Infect Dis 2019; 19: e110-19.

Authors:

Lancet Infect Dis 2019 Apr 16. Epub 2019 Apr 16.

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http://dx.doi.org/10.1016/S1473-3099(19)30208-7DOI Listing

Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial.

Lancet Diabetes Endocrinol 2019 May;7(5):e6-e17

Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Internal Medicine and Lipid Clinic, Department of Endocrinology and Nutrition, University of Barcelona, Barcelona, Spain.

Background: Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese.

Methods: PREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain. Read More

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http://dx.doi.org/10.1016/S2213-8587(19)30074-9DOI Listing

Correction to Lancet Diabetes Endocrinol 2016; 4: 633-35.

Authors:

Lancet Diabetes Endocrinol 2019 May;7(5):e5

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http://dx.doi.org/10.1016/S2213-8587(19)30121-4DOI Listing

Correction to Lancet Diabetes Endocrinol 2017; 5: 877-86.

Authors:

Lancet Diabetes Endocrinol 2019 May;7(5):e5

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http://dx.doi.org/10.1016/S2213-8587(19)30063-4DOI Listing

Change in albuminuria as a surrogate endpoint in chronic kidney disease - Authors' reply.

Lancet Diabetes Endocrinol 2019 May;7(5):336-337

Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(19)30080-4DOI Listing
May 2019
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Change in albuminuria as a surrogate endpoint in chronic kidney disease.

Lancet Diabetes Endocrinol 2019 May;7(5):335-336

Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, and Department of Immunology, Guangxi Area of Excellence, Guilin Medical University, Guilin 541004, China.

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http://dx.doi.org/10.1016/S2213-8587(19)30085-3DOI Listing

Change in albuminuria as a surrogate endpoint in chronic kidney disease.

Lancet Diabetes Endocrinol 2019 May;7(5):335

Department of Medicine and Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, ON LN8 3Z5, Canada; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/S2213-8587(19)30089-0DOI Listing

The end of HIV in the USA.

Authors:
Talha Burki

Lancet Infect Dis 2019 Apr 27;19(4):365-366. Epub 2019 Mar 27.

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http://dx.doi.org/10.1016/S1473-3099(19)30131-8DOI Listing

Progress and challenges of Lassa fever control in Nigeria.

Authors:
Paul Adepoju

Lancet Infect Dis 2019 Apr 27;19(4):364. Epub 2019 Mar 27.

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http://dx.doi.org/10.1016/S1473-3099(19)30130-6DOI Listing

Measles: a global resurgence.

Authors:
Sophie Cousins

Lancet Infect Dis 2019 Apr 27;19(4):362-363. Epub 2019 Mar 27.

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http://dx.doi.org/10.1016/S1473-3099(19)30129-XDOI Listing

Broadly neutralising antibodies in post-treatment control.

Lancet HIV 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23523018193007
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http://dx.doi.org/10.1016/S2352-3018(19)30075-XDOI Listing
April 2019
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Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial.

Lancet HIV 2019 Apr 15. Epub 2019 Apr 15.

US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA; SEARCH, the Thai Red Cross AIDS Research Center, Bangkok, Thailand; Department of Global Health, University of Amsterdam, Amsterdam, Netherlands.

Background: HIV-1-specific broadly neutralising antibodies such as VRC01 could promote HIV remission by halting viral replication and clearing infected cells. We investigated whether VRC01 could promote sustained viral control off antiretroviral therapy (ART) in adults who initiated ART during acute HIV infection.

Methods: We did a randomised, double-blind, placebo-controlled trial at the Thai Red Cross AIDS Research Centre in Bangkok, Thailand. Read More

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http://dx.doi.org/10.1016/S2352-3018(19)30053-0DOI Listing

Exploring the optimal use of alectinib.

Lancet Respir Med 2019 Apr 15. Epub 2019 Apr 15.

Cancer Medicine Department, Gustave Roussy Cancer Center, F-94805, Villejuif, France; University Paris-Sud, Faculty of Medicine, Le Kremlin-Bicêtre, France. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(19)30117-1DOI Listing

Early-onset emphysema in a large French-Canadian family: a genetic investigation.

Lancet Respir Med 2019 Apr 15. Epub 2019 Apr 15.

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec, Canada.

Background: Inherited mutations in SERPINA1 coding for the alpha-1 antitrypsin (A1AT) protein is the only well established cause of hereditary emphysema. We aimed to identify the genetic ecause of early-onset emphysema in a five-generation French-Canadian family free of A1AT deficiency.

Methods: Between Dec 1, 2014, and April 1, 2017, we investigated 63 individuals from a single pedigree, including 55 with DNA available. Read More

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http://dx.doi.org/10.1016/S2213-2600(19)30056-6DOI Listing

Advances in chronic obstructive pulmonary disease genetics: building the picture one piece at a time.

Lancet Respir Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35127 Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(19)30082-7DOI Listing

The gender gap in critical care task force participation.

Lancet Respir Med 2019 Apr 15. Epub 2019 Apr 15.

Critical Care Research Center, Regions Hospital, Saint Paul, Minnesota, MN 55101, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132600193012
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http://dx.doi.org/10.1016/S2213-2600(19)30120-1DOI Listing
April 2019
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Preparing for the next Ebola outbreak: in-country genomic capacity in Africa.

Lancet Infect Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Ede 200012, Nigeria; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede 200012, Nigeria. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(19)30173-2DOI Listing

Retrospective versus real-time Ebola virus sequencing.

Authors:
Miles W Carroll

Lancet Infect Dis 2019 Apr 15. Epub 2019 Apr 15.

Research and Development Institute, National Infection Service, Public Health England, Porton Down, Salisbury, Wilts SP40JG, UK. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(19)30207-5DOI Listing

2018 Ebola virus disease outbreak in Équateur Province, Democratic Republic of the Congo: a retrospective genomic characterisation.

Lancet Infect Dis 2019 Apr 15. Epub 2019 Apr 15.

Service de Microbiologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of the Congo; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.

Background: The 2018 Ebola virus disease (EVD) outbreak in Équateur Province, Democratic Republic of the Congo, began on May 8, and was declared over on July 24; it resulted in 54 documented cases and 33 deaths. We did a retrospective genomic characterisation of the outbreak and assessed potential therapeutic agents and vaccine (medical countermeasures).

Methods: We used target-enrichment sequencing to produce Ebola virus genomes from samples obtained in the 2018 Équateur Province outbreak. Read More

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http://dx.doi.org/10.1016/S1473-3099(19)30124-0DOI Listing

Medical countermeasures during the 2018 Ebola virus disease outbreak in the North Kivu and Ituri Provinces of the Democratic Republic of the Congo: a rapid genomic assessment.

Lancet Infect Dis 2019 Apr 15. Epub 2019 Apr 15.

Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo; Service de Microbiologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of the Congo.

Background: The real-time generation of information about pathogen genomes has become a vital goal for transmission analysis and characterisation in rapid outbreak responses. In response to the recently established genomic capacity in the Democratic Republic of the Congo, we explored the real-time generation of genomic information at the start of the 2018 Ebola virus disease (EVD) outbreak in North Kivu Province.

Methods: We used targeted-enrichment sequencing to produce two coding-complete Ebola virus genomes 5 days after declaration of the EVD outbreak in North Kivu. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14733099193011
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http://dx.doi.org/10.1016/S1473-3099(19)30118-5DOI Listing
April 2019
2 Reads

Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study.

Lancet Psychiatry 2019 Apr 8. Epub 2019 Apr 8.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Background: The polymorphic CYP2D6 enzyme metabolises the antipsychotic drugs risperidone and aripiprazole to their active metabolites, 9OH-risperidone and dehydroaripiprazole. The aim of this study was to quantify the effect of CYP2D6 genetic variability on risperidone and aripiprazole exposure and treatment in a large patient population.

Methods: We retrospectively obtained patient data from a routine therapeutic drug monitoring database at the Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway, between Jan 1, 2005, and Oct 15, 2018. Read More

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http://dx.doi.org/10.1016/S2215-0366(19)30088-4DOI Listing
April 2019
1 Read

CYP2D6 testing to guide risperidone and aripiprazole therapy.

Authors:
Chad A Bousman

Lancet Psychiatry 2019 Apr 8. Epub 2019 Apr 8.

Departments of Medical Genetics, Psychiatry, Physiology, and Pharmacology, and the Mathison Centre for Mental Health Research and Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N4N1, Canada; Alberta Children's Hospital Research Institute, Calgary, AB, Canada. Electronic address:

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http://dx.doi.org/10.1016/S2215-0366(19)30138-5DOI Listing

Lidocaine and phenylephrine versus saline placebo nasal spray for the pain and distress of nasogastric tube insertion in young children and infants: a randomised, double-blind, controlled trial.

Lancet Child Adolesc Health 2019 Apr 15. Epub 2019 Apr 15.

Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia; Paediatric Emergency Department, Monash Medical Centre, Melbourne, VIC, Australia.

Background: Nasogastric tube insertion is a common but distressing procedure in young children. We aimed to compare the efficacy of topical local anaesthetic and vasoconstrictor nasal spray with placebo for distress related to nasogastric tube insertion.

Methods: We did a prospective, randomised, controlled, double-blind, superiority trial in a single tertiary paediatric emergency department in Australia. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30058-6DOI Listing

The challenge of distinguishing pain from distress in young children.

Authors:
Rebeccah Slater

Lancet Child Adolesc Health 2019 Apr 15. Epub 2019 Apr 15.

Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23524642193011
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http://dx.doi.org/10.1016/S2352-4642(19)30118-XDOI Listing
April 2019
1 Read

Plaidoyer contre l'exclusion des francophones dans la recherche en santé mondiale.

Lancet Glob Health 2019 Apr 15. Epub 2019 Apr 15.

et Couverture Universelle Santé et parcours de vie. Organisation Mondiale de la Santé, Genève, Suisse.

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http://dx.doi.org/10.1016/S2214-109X(19)30175-5DOI Listing

Effect of ten-valent pneumococcal conjugate vaccine on invasive pneumococcal disease and nasopharyngeal carriage in Kenya: a longitudinal surveillance study.

Lancet 2019 Apr 15. Epub 2019 Apr 15.

Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine-Coast, Kilifi, Kenya; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; INDEPTH Network, Accra, Ghana.

Background: Ten-valent pneumococcal conjugate vaccine (PCV10), delivered at 6, 10, and 14 weeks of age was introduced in Kenya in January, 2011, accompanied by a catch-up campaign in Kilifi County for children aged younger than 5 years. Coverage with at least two PCV10 doses in children aged 2-11 months was 80% in 2011 and 84% in 2016; coverage with at least one dose in children aged 12-59 months was 66% in 2011 and 87% in 2016. We aimed to assess PCV10 effect against nasopharyngeal carriage and invasive pneumococcal disease (IPD) in children and adults in Kilifi County. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)33005-8DOI Listing

Population versus individual protection by pneumococcal conjugate vaccination.

Lancet 2019 Apr 15. Epub 2019 Apr 15.

Bill & Melinda Gates Foundation, Seattle, WA 98119, USA.

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http://dx.doi.org/10.1016/S0140-6736(19)30039-XDOI Listing

Effect of standard dose paracetamol versus placebo as antipyretic therapy on liver injury in adult dengue infection: a multicentre randomised controlled trial.

Lancet Glob Health 2019 May;7(5):e664-e670

Division of Infectious Diseases, Phramongkutklao Hospital, Bangkok, Thailand.

Background: Dengue is a common cause of acute liver failure in tropical countries. Paracetamol is the recommended antipyretic for dengue. Related observational studies in dengue have suggested that excessive paracetamol intake is related to hepatic injury. Read More

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http://dx.doi.org/10.1016/S2214-109X(19)30032-4DOI Listing

Sustaining pneumococcal vaccination after transitioning from Gavi support: a modelling and cost-effectiveness study in Kenya.

Lancet Glob Health 2019 May;7(5):e644-e654

Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: In 2009, Gavi, the World Bank, and donors launched the pneumococcal Advance Market Commitment, which helped countries access more affordable pneumococcal vaccines. As many low-income countries begin to reach the threshold at which countries transition from Gavi support to self-financing (3-year average gross national income per capita of US$1580), they will need to consider whether to continue pneumococcal conjugate vaccine (PCV) use at full cost or to discontinue PCV in their childhood immunisation programmes. Using Kenya as a case study, we assessed the incremental cost-effectiveness of continuing PCV use. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X183056
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http://dx.doi.org/10.1016/S2214-109X(18)30562-XDOI Listing
May 2019
1 Read

Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV (PURE): an international, community-based cohort study.

Lancet Glob Health 2019 May;7(5):e613-e623

Population Health Research Institute, Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.

Background: The associations between the extent of forced expiratory volume in 1 s (FEV) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations might vary across populations is unknown.

Methods: In this international, community-based cohort study, we prospectively enrolled adults aged 35-70 years who had no intention of moving residences for 4 years from rural and urban communities across 17 countries. A portable spirometer was used to assess FEV. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X193007
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http://dx.doi.org/10.1016/S2214-109X(19)30070-1DOI Listing
May 2019
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Reducing the cardiovascular disease burden for people of all ages in the Americas region: analysis of mortality data, 2000-15.

Lancet Glob Health 2019 May;7(5):e604-e612

Pan American Health Organization, Washington, DC, USA.

Background: In accordance with the age parameters specified in Sustainable Development Goal target 3.4, current policy and monitoring of non-communicable disease (NCD) mortality trends focus on people aged 30-69 years. This approach excludes the majority of NCD deaths, which occur at older ages. Read More

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http://dx.doi.org/10.1016/S2214-109X(19)30069-5DOI Listing

Population attributable fractions for risk factors for dementia in low-income and middle-income countries: an analysis using cross-sectional survey data.

Lancet Glob Health 2019 May;7(5):e596-e603

Division of Psychiatry, University College London, London, UK.

Background: Nine potentially modifiable risk factors (less childhood education, midlife hearing loss, hypertension, and obesity, and later-life smoking, depression, physical inactivity, social isolation, and diabetes) account for 35% of worldwide dementia, but most data to calculate these risk factors come from high-income countries only. We aimed to calculate population attributable fractions (PAFs) for dementia in selected low-income and middle-income countries (LMICs) to identify potential dementia prevention targets in these countries.

Methods: The study was an analysis of cross-sectional data obtained from the 10/66 Dementia Research surveys of representative populations in India, China, and six Latin America countries (Cuba, Dominican Republic, Mexico, Peru, Puerto Rico, and Venezuela), which used identical risk factor ascertainment methods in each country. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X193007
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http://dx.doi.org/10.1016/S2214-109X(19)30074-9DOI Listing
May 2019
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The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: a 12-month case-control study as a follow-on to the Global Enteric Multicenter Study (GEMS).

Lancet Glob Health 2019 May;7(5):e568-e584

University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Diarrheal diseases remain a leading cause of illness and death among children younger than 5 years in low-income and middle-income countries. The Global Enteric Multicenter Study (GEMS) has described the incidence, aetiology, and sequelae of medically attended moderate-to-severe diarrhoea (MSD) among children aged 0-59 months residing in censused populations in sub-Saharan Africa and south Asia, where most child deaths occur. To further characterise this disease burden and guide interventions, we extended this study to include children with episodes of less-severe diarrhoea (LSD) seeking care at health centres serving six GEMS sites. Read More

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http://dx.doi.org/10.1016/S2214-109X(19)30076-2DOI Listing

Effect of the Bolsa Familia Programme on tuberculosis treatment outcomes - Authors' reply.

Lancet Glob Health 2019 May;7(5):e566

Laboratory of Epidemiology, Federal University of Espirito Santo, Vitoria, Brazil. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(19)30153-6DOI Listing
May 2019
1 Read

Effect of the Bolsa Familia Programme on tuberculosis treatment outcomes.

Lancet Glob Health 2019 May;7(5):e565

Postgraduate Programme in Health Sciences, University of Southern Santa Catarina, Tubarão 88704-900, Brazil. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X193015
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http://dx.doi.org/10.1016/S2214-109X(19)30152-4DOI Listing
May 2019
1 Read

Gender-neutral HPV vaccination in Africa - Authors' reply.

Lancet Glob Health 2019 May;7(5):e564

Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston 77030, TX, USA; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston 77030, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(19)30065-8DOI Listing

Gender-neutral HPV vaccination in Africa.

Lancet Glob Health 2019 May;7(5):e563

Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(19)30073-7DOI Listing

Inequities in cervical cancer care in indigenous Peruvian women.

Lancet Glob Health 2019 May;7(5):e556-e557

Public Health, University of Illinois at Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1016/S2214-109X(19)30044-0DOI Listing