3,014 results match your criteria Lacunar Syndromes


Microbleeds of Lacunar Infarction and Middle Cerebral Artery Flow Velocity of Branch Atheromatous Disease Are Essential Factors of Stroke Etiology.

Eur Neurol 2019 Apr 23;81(1-2):19-23. Epub 2019 Apr 23.

Department of Neurology, Jikei University School of Medicine, Tokyo, Japan.

Background: Although subcortical infarction patients sometimes show larger infarction size than the definition of small vessel occlusion (SVO), there are no specific predictors of larger size. The aim of this study was to identify the factors, including magnetic resonance imaging (MRI) and ultrasonographic parameters, to predict larger subcortical infarction.

Methods: Consecutive patients with acute supratentorial subcortical infarction were studied. Read More

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http://dx.doi.org/10.1159/000494672DOI Listing

Erratum to Abnormal orthostatic blood pressure control among subjects with lacunar infarction.

Authors:

Eur Stroke J 2017 Mar 1;2(1):87. Epub 2017 Mar 1.

[This corrects the article DOI: 10.1177/2396987316663287.]. Read More

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http://dx.doi.org/10.1177/2396987316680773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453180PMC

Cryptogenic mechanism in ischaemic stroke patients is a predictor of 5-year survival: A population-based study.

Eur Stroke J 2016 Dec 10;1(4):279-287. Epub 2016 Sep 10.

Service de Neurologie et Unité Neuro-Vasculaire, CHRU, Brest, France.

Introduction: The present study sought to identify factors affecting mortality beyond 28 days in ischaemic stroke patients with whatever ischaemic mechanism.

Patients And Methods: A prospective population-based registry was set up in Brest County, Brittany, France. Demographic data, clinical presentation, vascular risk factors and mortality were collected from January 2008 to December 2012. Read More

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http://dx.doi.org/10.1177/2396987316669216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301247PMC
December 2016

Abnormal orthostatic blood pressure control among subjects with lacunar infarction.

Eur Stroke J 2016 Sep 4;1(3):222-230. Epub 2016 Aug 4.

Department of Medical Gerontology, Trinity College, Dublin, Ireland.

Introduction: Hypertension is a recognised risk factor for lacunar stroke. However, their association has been evaluated using static blood pressure (BP) assessment in supine or sitting position alone. We hypothesised that impaired dynamic (orthostatic) BP control may associate with lacunar strokes. Read More

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http://dx.doi.org/10.1177/2396987316663287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301241PMC
September 2016

Topographic distribution of white matter changes and lacunar infarcts in neurodegenerative and vascular dementia syndromes: A post-mortem 7.0-tesla magnetic resonance imaging study.

Eur Stroke J 2016 Jun 18;1(2):122-129. Epub 2016 May 18.

Université Lille 2, INSERM U 1171, Lille, France.

Background: White matter changes and lacunar infarcts are regarded as linked to the same underlying small-vessel pathology. On magnetic resonance imaging, white matter changes are frequently observed, while the number of lacunar infarcts is probably underestimated. The present study post-mortem 7. Read More

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http://dx.doi.org/10.1177/2396987316650780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301232PMC

The impact of early-life intelligence quotient on post stroke cognitive impairment.

Eur Stroke J 2018 Jun 8;3(2):145-156. Epub 2018 Jan 8.

3Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh.

Background: Cognitive impairment can complicate minor stroke, but there is limited information on risk factors including peak cognitive ability earlier in life.

Methods: We recruited patients with clinically-evident lacunar or minor non-lacunar ischaemic stroke, recorded clinical features, vascular risk factors, magnetic resonance imaging-detected stroke sub-type and small vessel disease burden. At 1-3 and 12 months after stroke, we assessed educational attainment (years of education), current cognition (Addenbrooke's Cognitive Examination-Revised), pre-morbid intelligence (National Adult Reading Test) and dependency (modified Rankin Scale). Read More

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http://dx.doi.org/10.1177/2396987317750517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460404PMC

Aspirin reduced recurrent stroke risk in patients with lacunar stroke.

Acta Neurol Scand 2019 Apr 19. Epub 2019 Apr 19.

Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100037, China.

Objectives: Lacunar stroke had an unfavorable prognosis in the long term with a high risk of recurrent stroke, aspirin has been widely used to prevent ischemic stroke, but data on the effect of antiplatelet therapy on lacunar infarction are limited. We investigated the long-term effect of aspirin treatment on stroke recurrence risk in patients with lacunar stroke in a multicenter prospective cohort.

Methods: Between November 2000 and November 2001, 2000 consecutive stroke patients (age 35-74 years) were recruited from seven clinical centers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13105
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http://dx.doi.org/10.1111/ane.13105DOI Listing
April 2019
6 Reads

Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL.

J Headache Pain 2019 Apr 17;20(1):36. Epub 2019 Apr 17.

Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mainly manifests with cognitive impairment. Cognitive deficits in patients with CADASIL are correlated with structural brain changes such as lacunar lesion burden, normalized brain volume, and anterior thalamic radiation lesions, but changes in resting-state functional brain activity in patients with CADASIL have not been reported.

Methods: This study used resting-state functional magnetic resonance imaging (fMRI) to measure the amplitude of low-frequency fluctuation (ALFF) in 22 patients with CADASIL and 44 healthy matched controls. Read More

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http://dx.doi.org/10.1186/s10194-019-0982-3DOI Listing

Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies.

J Stroke 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity and mortality worldwide. In most cases, CSVD is only recognized in its advanced stages once its symptomatic sequelae develop. However, its significance in asymptomatic healthy populations remains poorly defined. Read More

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http://www.j-stroke.org/journal/view.php?doi=10.5853/jos.201
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http://dx.doi.org/10.5853/jos.2018.03608DOI Listing
April 2019
2 Reads

Can we stop the stuttering in stroke? Interventions in 40 patients with acute lacunes.

J Neurol Sci 2019 Apr 6;401:1-4. Epub 2019 Apr 6.

Department of Neurology, Division of Critical Care Neurology, Mayo Clinic, Rochester, MN, United States of America.

Background: Whether any treatment can stop fluctuations of stuttering lacunar syndromes (SLS) is unclear. Case reports have variably suggested effectiveness of intravenous thrombolysis, dual antiplatelet treatment, blood pressure augmentation and anticoagulation. We aim to describe our experience with different treatments used in in patients presenting with SLS and their effect on clinical fluctuations and functional outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193016
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http://dx.doi.org/10.1016/j.jns.2019.04.009DOI Listing
April 2019
5 Reads

Teaching NeuroImages: Lacunar stroke and polyarteritis nodosa: Consider ADA2 deficiency (DADA2).

Neurology 2019 Apr;92(15):e1801-e1802

From the Department of Neurology, Division of Child Neurology (T.d.S.G., J.A.d.P.), Department of Radiology-INRAD, Division of Neuroradiology (C.A.P.F.A., L.T.L.), and Fleury Group (C.A.P.F.A.), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil.

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http://dx.doi.org/10.1212/WNL.0000000000007270DOI Listing

Extracranial Artery Stenosis Is Associated With Total MRI Burden of Cerebral Small Vessel Disease in Ischemic Stroke Patients of Suspected Small or Large Artery Origins.

Front Neurol 2019 21;10:243. Epub 2019 Mar 21.

Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Extracranial artery stenosis (ECAS) is related to individual imaging markers of cerebral small vessel disease (cSVD). However, little has been reported on the association between ECAS and the total burden of cSVD as assessed by magnetic resonance imaging (MRI). The purpose of this study was to investigate the relationship between ECAS and cSVD burden in patients with ischemic stroke of suspected small or large artery origin. Read More

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http://dx.doi.org/10.3389/fneur.2019.00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437037PMC
March 2019
1 Read

Outcome after intravenous thrombolysis in patients with acute lacunar stroke: An observational study based on SITS international registry and a meta-analysis.

Int J Stroke 2019 Apr 1:1747493019840947. Epub 2019 Apr 1.

1 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Background: Intravenous thrombolysis (IVT) for lacunar stroke (LS) is debated, as the underlying pathophysiological mechanism may not be thrombogenic.

Aims: To investigate outcomes after IVT in LS in the SITS International Stroke Thrombolysis Register and perform a meta-analysis.

Methods: LS was identified by both baseline NIHSS-subscores and discharge ICD-10 codes, and contrasted by IVT to non-IVT treated. Read More

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http://journals.sagepub.com/doi/10.1177/1747493019840947
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http://dx.doi.org/10.1177/1747493019840947DOI Listing
April 2019
3 Reads

Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images.

Comput Med Imaging Graph 2019 Mar 16;74:12-24. Epub 2019 Mar 16.

Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia, Spain.

Background: The differential quantification of brain atrophy, white matter hyperintensities (WMH) and stroke lesions is important in studies of stroke and dementia. However, the presence of stroke lesions is usually overlooked by automatic neuroimage processing methods and the-state-of-the-art deep learning schemes, which lack sufficient annotated data. We explore the use of radiomics in identifying whether a brain magnetic resonance imaging (MRI) scan belongs to an individual that had a stroke or not. Read More

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http://dx.doi.org/10.1016/j.compmedimag.2019.02.006DOI Listing
March 2019
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Small vessel occlusion is a high-risk etiology for early recurrent stroke after transient ischemic attack.

Int J Stroke 2019 Mar 27:1747493019840931. Epub 2019 Mar 27.

1 Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

Background: Recent prospective registration studies of transient ischemic attack in Western countries demonstrated that large artery atherosclerosis is the highest risk etiology for early stroke recurrence under urgent evaluation and treatment. On the other hand, some limited transient ischemic attack studies from East Asian countries showed transient ischemic attack patients due to small vessel occlusion were at a higher early stroke risk.

Aims: We aimed to assess the risk for early stroke in small vessel occlusion-transient ischemic attack patients in a Japanese large transient ischemic attack registry. Read More

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http://dx.doi.org/10.1177/1747493019840931DOI Listing
March 2019
1 Read

LDL Subclasses in Ischemic Stroke: A Risk Factor?

Noro Psikiyatr Ars 2019 Mar 5;56(1):13-17. Epub 2018 Jul 5.

Department of Cardiology, Balıklıgöl State Hospital, Şanlıurfa, Turkey.

Introduction: Seven low-density lipoprotein (LDL) subclasses are identified, and smaller LDL particles are associated with an increased risk for cardiovascular events. However, there is limited data about the relationship between the acute ischemic stroke (AIS) subtypes and LDL subclasses. The aim of our study is to investigate the relationship between AIS subtypes and LDL subclasses. Read More

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http://dx.doi.org/10.5152/npa.2017.19393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427071PMC
March 2019
1 Read

Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial.

JAMA Neurol 2019 Mar 25. Epub 2019 Mar 25.

Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Importance: The rationale for intravenous thrombolysis in patients with lacunar infarcts is debated, since it is hypothesized that the microvascular occlusion underlying lacunar infarcts might not be susceptible to pharmacological reperfusion treatment.

Objective: To study the efficacy and safety of intravenous thrombolysis among patients with lacunar infarcts.

Design, Setting, And Participants: This exploratory secondary post hoc analysis of the WAKE-UP trial included patients who were screened and enrolled between September 2012 and June 2017 (with final follow-up in September 2017). Read More

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http://dx.doi.org/10.1001/jamaneurol.2019.0351DOI Listing
March 2019
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Response to Ajay Kumar Mishra, et al. Lacunar strokes in Cryptococcal meningitis.

J Stroke Cerebrovasc Dis 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, Division of Infectious Diseases; University of Colorado, Denver, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.038DOI Listing
March 2019
2 Reads

Neurovascular Ageing and Age-Related Diseases.

Subcell Biochem 2019;91:477-499

Institute of Neuroscience, Newcastle University, Campus for Ageing & Vitality, Newcastle upon Tyne, UK.

Proper functioning of the brain is dependent on integrity of the cerebral vasculature. During ageing, a number of factors including aortic or arterial stiffness, autonomic dysregulation, neurovascular uncoupling and blood-brain barrier (BBB) damage will define the dynamics of brain blood flow and local perfusion. The nature and extent of ageing-related cerebrovascular changes, the degree of involvement of the heart and extracranial vessels and the consequent location of tissue pathology may vary considerably. Read More

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http://dx.doi.org/10.1007/978-981-13-3681-2_17DOI Listing
January 2019
2 Reads

Letter to Editor on "Lacunar Stroke in Cryptococcal Meningitis: Clinical and Radiographic Features".

J Stroke Cerebrovasc Dis 2019 Mar 15. Epub 2019 Mar 15.

Department of Internal Medicine and Endocrinology, Christian Medical College, Vellore, Tamil Nadu, India.

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https://linkinghub.elsevier.com/retrieve/pii/S10523057193006
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.024DOI Listing
March 2019
3 Reads

High Prevalence of Cerebral Small Vessel Disease on 7T Magnetic Resonance Imaging in Familial Hypercholesterolemia.

J Atheroscler Thromb 2019 Mar 15. Epub 2019 Mar 15.

Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University.

Aim: It remains unclear whether elevated low-density lipoprotein cholesterol (LDL-C) is a risk factor for cerebral vascular disease. Familial hypercholesterolemia (FH) is the most appropriate model for understanding the effects of excess LDL-C because affected individuals have inherently high levels of circulating LDL-C. To clarify the effects of hypercholesterolemia on cerebral small vessel disease (SVD), we investigated cerebrovascular damage in detail due to elevated LDL-C using high resolution brain magnetic resonance imaging (MRI) in patients with FH. Read More

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http://dx.doi.org/10.5551/jat.48553DOI Listing
March 2019
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Interarm Blood Pressure Difference has Various Associations with the Presence and Burden of Cerebral Small-Vessel Diseases in Noncardioembolic Stroke Patients.

J Clin Neurol 2019 Apr 11;15(2):159-167. Epub 2019 Mar 11.

Department of Neurology, College of Medicine, Ewha Womans University, Seoul, Korea.

Background And Purpose: An interarm blood pressure difference (IABD) is independently related to the occurrence of cardiovascular disease and mortality. Cerebral small-vessel diseases (SVDs) are important risk factors for stroke, cognitive dysfunction, and mortality. We aimed to determine whether IABD is related to cerebral SVDs. Read More

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http://dx.doi.org/10.3988/jcn.2019.15.2.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444144PMC
April 2019
3 Reads
1.807 Impact Factor

Leukoaraiosis is an independent predictor of intracranial hemorrhage in patients with atrial fibrillation.

J Thromb Thrombolysis 2019 May;47(4):527-532

Department of Life, Health & Environmental Sciences, University of L'Aquila, Piazzale S. Tommasi, Coppito- L'Aquila, Italy.

We evaluated the predictive value of several clinical, radiological and laboratory parameters on the risk of predict intracranial hemorrhage (ICH) in patients with atrial fibrillation (AF). We conducted a case-control study on a consecutive hospital based series of patients with AF and ICH. A random sample of subjects with AF without ischemic or hemorrhagic stroke was selected from the same hospital in the same period to perform as the control group, with a ratio of two controls per case. Read More

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http://dx.doi.org/10.1007/s11239-019-01839-4DOI Listing
May 2019
1 Read

Response by Förster et al to Letter Regarding Article, "Gadolinium Leakage in Ocular Structures Is Common in Lacunar Infarction".

Stroke 2019 Apr;50(4):e115

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Germany.

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http://dx.doi.org/10.1161/STROKEAHA.119.024701DOI Listing
April 2019
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Letter by Gao et al Regarding Article, "Gadolinium Leakage in Ocular Structures Is Common in Lacunar Infarction".

Stroke 2019 Apr;50(4):e114

Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1161/STROKEAHA.118.024538DOI Listing
April 2019
2 Reads
5.723 Impact Factor

Stroke in the Middle-East and North Africa: A 2-year prospective observational study of stroke characteristics in the region-Results from the Safe Implementation of Treatments in Stroke (SITS)-Middle-East and North African (MENA).

Int J Stroke 2019 Mar 12:1747493019830331. Epub 2019 Mar 12.

2 Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.

Background And Methods: Stroke incidence and mortality are reported to have increased in the Middle-East and North African (MENA) countries during the last decade. This was a prospective observational study to examine the baseline characteristics of stroke patients in the MENA region and to compare the MENA vs. the non-MENA stroke cohort in the Safe Implementation of Treatments in Stroke (SITS) International Registry. Read More

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http://dx.doi.org/10.1177/1747493019830331DOI Listing
March 2019
4 Reads
3.833 Impact Factor

IL-1α and IL-6 predict vascular events or death in patients with cerebral small vessel disease-Data from the SHEF-CSVD study.

Adv Med Sci 2019 Mar 4;64(2):258-266. Epub 2019 Mar 4.

Clinic of Neurology, Military Institute of Medicine, Warsaw, Poland.

Purpose: The natural clinical course of cerebral small vessel disease (CSVD) was not thoroughly described. The aim of this single center cohort study was to establish biochemical predictors of vascular events and death in CSVD patients during a 24-month follow-up.

Patients And Methods: A total of 130 functionally independent patients with marked MRI features of CSVD and recent lacunar stroke (n = 52,LS), vascular Parkinsonism (n = 28,VaP) or dementia (n = 50,VaD) were prospectively recruited. Read More

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http://dx.doi.org/10.1016/j.advms.2019.02.003DOI Listing
March 2019
3 Reads

Dual Antiplatelet Therapy Improves Functional Outcome in Patients With Progressive Lacunar Strokes.

Stroke 2019 Apr;50(4):1007-1009

From the Department of Neurology, Heidelberg University Hospital, Germany.

Background and Purpose- In 20% to 30% of patients with lacunar strokes, early neurological deterioration (END) occurs within the first days after stroke onset. However, effective treatment strategies are still missing for these patients. The purpose of this study was to analyze efficacy of dual antiplatelet therapy (DAPT) in patients presenting with END. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023789DOI Listing
April 2019
1 Read

Branch atheromatous disease has a stronger association with late-onset epileptic seizures than lacunar infarction in Japanese patients.

J Int Med Res 2019 Mar 6:300060519831572. Epub 2019 Mar 6.

1 Department of Neurology, Kurashiki Central Hospital, Okayama, Japan.

Objective: To evaluate the relationship between late-onset epileptic seizures and non-cortical infarction (namely, lacunar infarction and branch atheromatous disease [BAD]) in Japanese patients.

Methods: We reviewed the medical records and brain magnetic resonance imaging findings of all patients with ischemic stroke admitted to the Departments of Neurology, Neurosurgery, and Stroke Unit at Kurashiki Central Hospital from 1 January 2011 to 31 December 2012. Patients with lacunar infarction and BAD were enrolled; those with cortical and brain stem ischemic lesions were excluded. Read More

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http://dx.doi.org/10.1177/0300060519831572DOI Listing
March 2019
2 Reads

Is lipoprotein(a) a risk factor for ischemic stroke and venous thromboembolism?

Clin Res Cardiol Suppl 2019 Apr;14(Suppl 1):28-32

Institute of Clinical Chemistry, University and University Hospital of Zurich, Raemistraße 100, 8091, Zurich, Switzerland.

The structural similarity with plasminogen as well as thrombogenic and atherogenic in vitro functions raise the question if lipoprotein(a) (Lp(a)) is a risk factor for venous thromboembolism (VTE) and ischemic stroke. Numerous case-control and prospective studies using different cut-off values to define high Lp(a) generated conflicting evidence for both VTE and ischemic stroke. Several meta-analyses demonstrated independent associations of elevated Lp(a) with a history of VTE or ischemic stroke. Read More

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http://dx.doi.org/10.1007/s11789-019-00101-8DOI Listing
April 2019
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The global burden of cerebral small vessel disease related to neurological deficit severity and clinical outcomes of acute ischemic stroke after IV rt-PA treatment.

Neurol Sci 2019 Mar 4. Epub 2019 Mar 4.

Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu, 215006, People's Republic of China.

Background And Purpose: Various types of cerebral small vessel diseases (CSVD) are commonly coexisting and the clinical outcome possibly is determined by their combined effect. The present study was designed to explore the possible relationship between the global burden of CSVD and clinical outcomes after recombinant tissue plasminogen activator (rt-PA) treatment of ischemic stroke.

Methods: We enrolled patients with acute ischemic stroke (AIS) after IV rt-PA treatment between August 2016 and July 2018. Read More

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http://dx.doi.org/10.1007/s10072-019-03790-xDOI Listing
March 2019
4 Reads

Intraventricular Meningioma Presenting As Lateral Posterior Choroidal Artery Stroke.

World Neurosurg 2019 Feb 26. Epub 2019 Feb 26.

Department Of Neurosurgery, All India Institute of Medical Sciences, New Delhi.

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http://dx.doi.org/10.1016/j.wneu.2019.02.055DOI Listing
February 2019
1 Read

Ischemic Stroke Incidence in Patients With Microvascular Ocular Motor Palsy Versus Patients With Lacunar Ischemic Stroke.

Neurologist 2019 Mar;24(2):50-52

Neurology Department, Coimbra University Hospital Centre.

Objective: Presumed microvascular ischemia is the most frequent cause of ocular motor palsy (OMP). Ischemic stroke incidence after an episode of microvascular OMP (mOMP) is not established, contrasting with other common vascular conditions, such as lacunar ischemic stroke (LS). We sought to compare the incidence of subsequent ischemic stroke between mOMP and LS populations. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000213DOI Listing
March 2019
1 Read

Home-based aerobic exercise in patients with lacunar stroke: Design of the HITPALS randomized controlled trial.

Contemp Clin Trials Commun 2019 Jun 2;14:100332. Epub 2019 Feb 2.

Department of Neurology, Neurovascular Research Unit, Herlev GentofteHospital, Copenhagen, Denmark.

Background: The effects of physical exercise in patients with lacunar stroke, seem promising in secondary prevention and only few studies have investigated the effect of high-intensity interval training in patients with lacunar stroke. This study will be investigating whether high-intensity interval training improves cardiovascular fitness as well as cognitive- and endothelial function and potentially attenuating the risk of recurrent stroke.

Methods: A randomized controlled trial evaluating 12 weeks of home-based, high-intensity interval training compared with usual care. Read More

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http://dx.doi.org/10.1016/j.conctc.2019.100332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378897PMC
June 2019
4 Reads

Correlations of C-Reactive Protein (CRP), Interleukin-6 (IL-6), and Insulin Resistance with Cerebral Infarction in Hypertensive Patients.

Med Sci Monit 2019 Feb 26;25:1506-1511. Epub 2019 Feb 26.

Department of Neurology, Linyi Central Hospital, Linyi, Shandong, China (mainland).

BACKGROUND The aim of this study was to investigate the correlations of C-reactive protein (CRP), interleukin-6 (IL-6), and insulin resistance (IR) with cerebral infarction in hypertensive patients. MATERIAL AND METHODS A total of 80 patients with cerebral infarction admitted to our hospital from March 2016 to November 2017 were selected and divided into 2 groups according to the diameter of cerebral infarction, namely, lacunar cerebral infarction group (n=40) and cerebral infarction group (n=40). The levels of high-sensitivity CRP (hs-CRP) and IL-6, homeostasis model assessment of IR (HOMA-IR) index and blood pressure level were compared between the 2 groups. Read More

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http://dx.doi.org/10.12659/MSM.912898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400023PMC
February 2019

Amino Acid Biosignature in Plasma among Ischemic Stroke Subtypes.

Biomed Res Int 2019 20;2019:8480468. Epub 2019 Jan 20.

Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte-MG, Brazil.

Ischemic stroke is a neurovascular disorder caused by reduced or blockage of blood flow to the brain, which may permanently affect motor and cognitive abilities. The diagnostic of stroke is performed using imaging technologies, clinical evaluation, and neuropsychological protocols, but no blood test is available yet. In this work, we analyzed amino acid concentrations in blood plasma from poststroke patients in order to identify differences that could characterize the stroke etiology. Read More

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https://www.hindawi.com/journals/bmri/2019/8480468/
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http://dx.doi.org/10.1155/2019/8480468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360633PMC
January 2019
5 Reads

Time-domain near-infrared spectroscopy in acute ischemic stroke patients.

Neurophotonics 2019 Jan 7;6(1):015003. Epub 2019 Feb 7.

San Raffaele Scientific Institute, Neurology Department, Via Olgettina, Milan, Italy.

Large vessel occlusion (LVO) stroke might cause different degrees of hemodynamic impairment that affects microcirculation and contributes to metabolic derangement. Time-domain near-infrared spectroscopy (TD-NIRS) estimates the oxygenation of microcirculation of cerebral outer layers. We measure hemoglobin species and tissue oxygen saturation ( ) of anterior circulation stroke patients, classified as LVO or lacunar, and assess the differences compared with controls and according to LVO recanalization status. Read More

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http://dx.doi.org/10.1117/1.NPh.6.1.015003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365799PMC
January 2019

Focal Hypoperfusion in Acute Ischemic Stroke Perfusion CT: Clinical and Radiologic Predictors and Accuracy for Infarct Prediction.

AJNR Am J Neuroradiol 2019 Mar 21;40(3):483-489. Epub 2019 Feb 21.

From the Neurology Service (O.B., D.L., P.M.), Department of Clinical Neurosciences.

Background And Purpose: Perfusion CT may improve the diagnostic performance of noncontrast CT in acute ischemic stroke. We assessed predictors of focal hypoperfusion in acute ischemic stroke and perfusion CT performance in predicting infarction on follow-up imaging.

Materials And Methods: Patients from the Acute STroke Registry and Analysis of Lausanne data base with acute ischemic stroke and perfusion CT were included. Read More

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http://dx.doi.org/10.3174/ajnr.A5984DOI Listing

Use of transcutaneous electrical acupoint stimulation for prevention of postoperative delirium in geriatric patients with silent lacunar infarction.

Clin Interv Aging 2019 1;14:249-252. Epub 2019 Feb 1.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China,

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http://dx.doi.org/10.2147/CIA.S197922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363397PMC
March 2019
1 Read

Cerebrovascular disease burden in late-onset non-lesional focal epilepsy.

Seizure 2019 Mar 8;66:31-35. Epub 2019 Feb 8.

Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain. Electronic address:

Purpose: Late-onset non-lesional focal epilepsy, defined as new-onset seizures in patients older than 60 years, is diagnosed increasingly more often in relation to aging of the population. It has been attributed mainly to occult cerebral small vessel disease (SVD), although high levels of evidence to support this notion are lacking. This study aimed to evaluate the burden of leukoaraiosis, a marker of cerebral SVD, and hippocampal atrophy in patients with late-onset epilepsy (LOE). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.004DOI Listing
March 2019
1 Read

The Clinical Phenotype of Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.

J Alzheimers Dis 2019 ;68(1):311-322

Department of Neurology, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Type 2 diabetes mellitus (T2DM) increases the risk of vascular cognitive impairment (VCI). It is unknown which type of vascular lesions and co-morbid etiologies, in particular Alzheimer's disease pathology, are associated with T2DM in patients with VCI, and how this relates to cognition and prognosis.

Objective: To compare brain MRI and cerebrospinal fluid (CSF) markers, cognition, and prognosis in patients with possible VCI with and without T2DM. Read More

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http://dx.doi.org/10.3233/JAD-180914DOI Listing
January 2019
1 Read

Twenty-and-a-half syndrome: a case report.

J Med Case Rep 2019 Feb 15;13(1):35. Epub 2019 Feb 15.

Department of Neurology, Sri Aurobindo Medical College & P.G. Institute, 4th Floor, Sanwer Road, Indore, MP, 453555, India.

Background: In the list of named numerical neuro-ophthalmological syndromes, such as one-and-a-half syndrome and others, we report for the first time twenty-and-a-half syndrome, which is characterized by one-and-a-half syndrome with bilateral seventh and right fifth nerve palsy (1.5 + 7 + 7 + 5 = 20.5) in a patient with ischemic stroke. Read More

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http://dx.doi.org/10.1186/s13256-019-1980-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376777PMC
February 2019
1 Read

Increased blood pressure variability following acute stroke is associated with poor long-term outcomes: a systematic review.

Blood Press Monit 2019 Apr;24(2):67-73

Department of Cardiovascular Sciences.

Background: Blood pressure variability (BPV) in acute ischemic stroke (AIS) may be of prognostic significance. However, methodological heterogeneity of studies may contribute to inconsistent findings, and study findings are therefore not readily comparable. We investigated study methodologies which have assessed the long-term outcomes (≥7 days) of BPV post-AIS. Read More

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http://dx.doi.org/10.1097/MBP.0000000000000366DOI Listing
April 2019
2 Reads

Cortical Cerebral Microinfarcts on 3T Magnetic Resonance Imaging in Patients With Carotid Artery Stenosis.

Stroke 2019 Mar;50(3):639-644

From the Department of Neurology (J.T., K.M., S.O., K.T., T.S., M.S., H.M.), Osaka University Graduate School of Medicine, Japan.

Background and Purpose- Carotid artery stenosis is common in the elderly and contributes to cognitive impairment and dementia. Cortical cerebral microinfarcts (CMIs) play an important role in vascular cognitive impairment and dementia. We aimed to investigate the association between CMIs on 3T magnetic resonance imaging and clinical and radiological features, including plaque morphology, and cognitive function in patients with carotid stenosis. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023781DOI Listing
March 2019
8 Reads

Early microvascular cerebral blood flow response to head-of-bed elevation is related to outcome in acute ischemic stroke.

J Neurol 2019 Apr 9;266(4):990-997. Epub 2019 Feb 9.

Department of Neurology, Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Background And Aims: Previously, microvascular cerebral blood flow (CBF) response to a mild head-of-bed (HOB) elevation has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS). We have hypothesized that early CBF response is related to the functional outcome.

Methods: Patients with a non-lacunar AIS in the anterior circulation were monitored by DCS to measure relative CBF (ΔrCBF) on the frontal lobes bilaterally during a 0°-30° HOB elevation at early (≤ 12) or late (> 12) hours from symptom onset. Read More

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http://dx.doi.org/10.1007/s00415-019-09226-yDOI Listing
April 2019
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Radiological features and outcomes of essential thrombocythemia-related stroke.

J Neurol Sci 2019 Mar 22;398:135-137. Epub 2019 Jan 22.

Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Background: Essential thrombocythemia (ET) is known to be associated with an increased vascular event, but the stroke patterns and prognosis have not been studied.

Methods: Between January 2013 and December 2017, acute ischemic stroke patients with ET who were admitted to two tertiary hospital stroke centers in Seoul, Korea were included. We retrospectively reviewed their clinical, laboratory and imaging data. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.035DOI Listing
March 2019
2 Reads

Cerebral White Matter Hyperintensities, Kidney Function Decline, and Recurrent Stroke After Intensive Blood Pressure Lowering: Results From the Secondary Prevention of Small Subcortical Strokes ( SPS 3) Trial.

J Am Heart Assoc 2019 Feb;8(3):e010091

1 Kidney Health Research Collaborative University of California, San Francisco San Francisco CA.

Background We aimed to determine whether cerebral white matter hyperintensities ( WMHs ) can distinguish stroke survivors susceptible to rapid kidney function decline from intensive blood pressure ( BP ) lowering. Methods and Results The SPS3 (Secondary Prevention of Small Subcortical Strokes) trial randomized participants with recent lacunar stroke to systolic BP targets of 130 to 149 and <130 mm Hg. We included 2454 participants with WMH measured by clinical magnetic resonance imaging at baseline and serum creatinine measured during follow-up. Read More

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http://dx.doi.org/10.1161/JAHA.118.010091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405594PMC
February 2019
3 Reads

The use of motor learning and neural plasticity in rehabilitation for ataxic hemiparesis: A case report.

Physiother Theory Pract 2019 Jan 27:1-10. Epub 2019 Jan 27.

b Physical Therapy, Mayo Clinic , College of Medicine and Science , Rochester , MN , USA.

Background And Purpose: Although the principles of neural plasticity for stroke rehabilitation are well established, specific intervention plans for patients with ataxia following a lacunar infarct are not well described. The purpose of this case report is to describe the intervention program for a patient with ataxic hemiparesis based on principles of motor learning and neural plasticity.

Case Description: An 83-year-old, socially active male presented to the emergency department with right-sided upper extremity weakness and ataxia. Read More

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http://dx.doi.org/10.1080/09593985.2019.1566941DOI Listing
January 2019

Blood Pressure Gradients in the Brain: Their Importance to Understanding Pathogenesis of Cerebral Small Vessel Disease.

Authors:
J David Spence

Brain Sci 2019 Jan 23;9(2). Epub 2019 Jan 23.

Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, 1400 Western Road, London, ON N6G 2V4, Canada.

The term "lacunar infarction" referred to small infarctions in the basal ganglia, internal capsule, thalamus, and brainstem, due to hypertensive small vessel disease. However, it has become common to refer to all small infarctions as "vascular centrencephalon", where short straight arteries with few branches transmit high blood pressure straight through to end-arterioles. The cortex is supplied by long arteries with many branches, so there is a very large blood pressure gradient in the brain. Read More

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http://dx.doi.org/10.3390/brainsci9020021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406272PMC
January 2019
1 Read

Evolution of acute lacunar lesions in terms of size and shape: a PICASSO sub-study.

J Neurol 2019 Mar 23;266(3):766-772. Epub 2019 Jan 23.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

The imaging definition of lacunar infarcts is variable, particularly regarding their size and the presence of cavitation. We investigated the changes of diameter and evolution pattern of acute lacunar infarcts, and the factors associated with the evolution pattern. Patients with acute single subcortical hemispheric or brainstem ischemic lesions of penetrating arterial territories were included. Read More

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http://link.springer.com/10.1007/s00415-019-09201-7
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http://dx.doi.org/10.1007/s00415-019-09201-7DOI Listing
March 2019
6 Reads