5,116 results match your criteria Lacunar Syndromes


[Analysis of nystagmus and medical history of 121 patients positive with positional test].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1491-1494

Department of Otolaryngology, Kuang Tien General Hospital, Taichung, Taiwan.

To observe the characteristics of positional nystagmus and clinical profile of patients with positive positional test, and to explore its possible pathogenesis. One hundred and twenty-one patients with positive positional test in the vestibular function examination were enrolled in the Peking University International Hospital from January to June in 2017. According to the 2017 BPPV guidelines, patients with test positive positional nystagmus were divided into two groups: definite BPPV and the controversial syndrome. Read More

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October 2018

Are serum autoantibodies associated with brain changes in systemic lupus erythematosus? MRI data from the Leiden NP-SLE cohort.

Lupus 2018 Dec 8:961203318816819. Epub 2018 Dec 8.

1 Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.

Objective: The effect of serum autoantibodies on the brain of systemic lupus erythematosus (SLE) patients remains unclear. We investigated whether serum autoantibodies, individually and assessed in groups, are associated with specific brain-MRI abnormalities or whether these structural changes are associated with other SLE-related or traditional cardiovascular disease risk factors.

Methods: All patients underwent brain 3Tesla-MRI. Read More

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December 2018

Differences in Ischemic Anterior and Posterior Circulation Strokes: A Clinico-Radiological and Outcome Analysis.

J Stroke Cerebrovasc Dis 2018 Nov 27. Epub 2018 Nov 27.

Stroke Center/Neurology Service of the Lausanne University Hospital, Switzerland.

Background: There are limited data comparing posterior (PC) and anterior (AC) circulation acute ischemic strokes (AIS). We aimed to identify specific features of PC and AC strokes regarding clinical, etiological, radiological, and outcome factors.

Methods: Patients from the Acute STroke Registry and Analysis of Lausanne, a prospective cohort of consecutive AIS, from years 2003 to 2008 were included. Read More

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November 2018
3 Reads

Consequence of Ischemic Stroke after Coronary Surgery with Cardiopulmonary Bypass According to Stroke Subtypes.

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):462-468

Department of Cardiovascular Surgery, Istanbul Medeniyet University Medical Faculty, Istanbul, Turkey.

Introduction: The aim of this study was to determine the outcomes of patients developing ischemic stroke after coronary artery bypass grafting (CABG).

Methods: From March 2012 to January 2017, 5380 consecutive patients undergoing elective coronary surgery were analyzed. Ninety-five patients who developed ischemic strokes after on-pump coronary surgery were included in the study, retrospectively. Read More

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March 2018
2 Reads
0.632 Impact Factor

Aging and cerebrovascular lesions in pure and in mixed neurodegenerative and vascular dementia brains: a neuropathological study.

Folia Neuropathol 2018 ;56(2):81-87

Introduction: The prevalence of dementia is increasing in our aging population. Because of the complexity of disease pathology, dementia classifications remain controversial. The present post-mortem study investigates whether there are age differences between dementia brains with a single pure neurodegenerative or cerebrovascular disease and those with mixed pathological features. Read More

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January 2018
1 Read

[The association of hemostasis system genes with the development of ischemic stroke in patients under the age of 50 years].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(9. Vyp. 2):14-21

Research Institute of Cerebrovascular Pathology and Stroke, Pirogov Russian National Research Medical University, Moscow, Russia; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.

Aim: To study an influence of polymorphic variants of hemostasis system genes on the risk of ischemic stroke (IS) in patients of the Slavic population under the age of 50 years.

Material And Methods: Ninety-two patients (19 women and 73 men), aged 18-50 years, were examined. The diagnosis of stroke was confirmed by neuroimaging (CT or MRI) in all patients. Read More

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January 2018

Multiple infarcts and hemorrhages in the central nervous system of a dog with cerebral amyloid angiopathy: a case report.

BMC Vet Res 2018 Nov 27;14(1):370. Epub 2018 Nov 27.

Departament of Pathology, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof Dr. Orlando Marques de Paiva, 87, São Paulo, 05508-270, Brazil.

Background: β-amyloid (Aβ) can accumulate in the brain of aged dogs, and within vessels walls, the disease is called cerebral amyloid angiopathy (CAA). In humans, Alzheimer's disease and CAA are strongly correlated with cerebrovascular disease. However, in dogs, this association has not been extensively studied yet. Read More

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November 2018
1 Read

Early microalbuminuria as a clinical marker for acute cerebral small vessel infarction.

Neurol Res 2018 Nov 26:1-5. Epub 2018 Nov 26.

a Department of Neurology , ShengJing Hospital of China Medical University , Shenyang , Liaoning , P.R. China.

Background: Previous studies have shown the potential interactions between cerebrovascular diseases and microalbuminuria. However, the relationship between urine microalbumin and acute lacunar infarction caused by cerebral small vessel disease (CSVD) remains unknown.

Methods: The clinical data of 148 patients with acute lacunar infarction admitted to the Department of Neurology, Shengjing Hospital of China Medical University between April 2016 and April 2017 were analyzed. Read More

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November 2018
4 Reads

Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction.

Sleep Med 2018 Jun 26;53:81-87. Epub 2018 Jun 26.

Department of Neurology, Methodist Neurological Institute, Prof. Neurology Weill Cornell Medical School, Houston, TX, USA. Electronic address:

Background: Recent studies have suggested that cerebral ischemic infarction may contribute to the development of restless legs syndrome (RLS). This study analyzed the clinical and radiological profiles of RLS with onset after acute lacunar infarction.

Methods: In this retrospective study we enrolled 244 consecutive patients with acute lacunar infarction between January 2012 and June 2014. Read More

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June 2018
3 Reads

3T MRI study discloses high intrafamilial variability in CADASIL due to a novel NOTCH3 mutation.

J Clin Neurosci 2018 Dec 24;58:25-29. Epub 2018 Oct 24.

Department of Neuroradiology, Montreal Neurological Institute and Hospital, McGill University, 3801 rue University, Montreal H3A2B4, QC, Canada. Electronic address:

In order to evaluate the usefulness of presymptomatic MRI, we performed 3T brain MRI and Sanger gene sequencing in a proband with suspected but not confirmed CADASIL and her apparently asymptomatic father. The 35-year-old proband presented with migraine with visual aura. Brain MRI showed diffuse leukoencephalopathy, suggesting CADASIL. Read More

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December 2018
3 Reads

Recurrent thrombolysis of a stuttering lacunar infarction captured on serial MRIs.

eNeurologicalSci 2018 Dec 30;13:14-17. Epub 2018 Oct 30.

Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.

Lacunar strokes account for about a fourth of all ischemic strokes. Pontine infarcts often present with stuttering symptoms, referred to as pontine warning syndrome (PWS). Patients presenting with fluctuating symptoms can appear to have rapidly improving symptoms and thus often go untreated despite the risk of recurrent deficits. Read More

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December 2018
1 Read

Dynamic Evaluation of Orthodontically-Induced Tooth Movement, Root Resorption, and Alveolar Bone Remodeling in Rats by in Vivo Micro-Computed Tomography.

Med Sci Monit 2018 Nov 18;24:8306-8314. Epub 2018 Nov 18.

Department of Orthodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, China (mainland).

BACKGROUND The aim of this study was to dynamically evaluate tooth movement, root resorption, and remodeling of alveolar bone using different forces to cause tooth movement in rats. MATERIAL AND METHODS 12-week-old male Sprague-Dawley rats were selected. Nickel-titanium (Ni-Ti) coil springs (20 g, 50 g, and 100 g forces) were placed for mesial movement of the left first maxillary molar teeth. Read More

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November 2018
4 Reads

Association between carotid artery plaque inflammation and brain MRI.

J Neuroradiol 2018 Nov 12. Epub 2018 Nov 12.

Department of Pathology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari, Polo di Monserrato. ss. 554 Monserrato (Cagliari) 09045, Italy.

Purpose: To explore the association between presence of inflammatory cells in the carotid plaques surgically treated and brain MRI findings.

Material And Methods: Forty consecutive patients were prospectively analyzed. Brain MRI was performed with a 1. Read More

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November 2018
1 Read

Arterial stiffness and total cerebral small vessel disease score in community-dwelling older adults: Results from the Atahualpa Project.

Vasc Med 2018 Nov 14:1358863X18806583. Epub 2018 Nov 14.

1 School of Medicine, Universidad Espíritu Santo-Ecuador, Guayaquil, Ecuador.

Information on the association between arterial stiffness and cerebral small vessel disease (cSVD) is limited and confined to white and Asian populations. More regional information is needed to confirm this association in different ethnic groups. Using the Atahualpa Project cohort, we aimed to assess whether the aortic pulse wave velocity (PWV) is associated with the total cSVD score, as well as with each of the neuroimaging signatures of cSVD, in a population of Amerindians living in rural Ecuador. Read More

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November 2018
5 Reads

Transcutaneous electrical acupoint stimulation for prevention of postoperative delirium in geriatric patients with silent lacunar infarction: a preliminary study.

Clin Interv Aging 2018 24;13:2127-2134. Epub 2018 Oct 24.

Department of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang City, Hebei, People's Republic of China,

Purpose: This study aims to investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative delirium (POD) in elderly patients with silent lacunar infarct and preliminarily to determine the relationship among TEAS, blood-brain barrier (BBB), neuroinflammation, and POD.

Patients And Methods: Sixty-four-old patients with silent lacunar infarct were randomly divided into two groups: group TEAS and control group (group C). Patients in the group TEAS received TEAS (disperse-dense waves; frequency, 2/100 Hz) on acupoints Hegu and Neiguan of both sides starting from 30 minutes before induction of anesthesia until the end of surgery, and the intensity was the maximum current that could be tolerated. Read More

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October 2018
1 Read
1.824 Impact Factor

Periodontitis is associated with systemic inflammation and vascular endothelial dysfunction in patients with lacunar infarct.

J Periodontol 2018 Nov 12. Epub 2018 Nov 12.

Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

Background: Periodontitis has been associated with lacunar infarct (LI), a type of cerebral small vessel disease. The objective of this study was to ascertain whether periodontitis is associated with increased circulating levels of systemic inflammation and endothelial dysfunction biomarkers in patients with LI.

Methods: One hundred twenty patients with LI and 120 healthy controls underwent a full-mouth periodontal examination. Read More

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November 2018
2 Reads

Subjective Cognitive Decline Is Associated with Greater White Matter Hyperintensity Volume.

J Alzheimers Dis 2018 ;66(3):1283-1294

Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI, USA.

Background: Research in older adults with subjective cognitive decline (SCD) has mainly focused on Alzheimer's disease (AD)-related MRI markers, such as hippocampal volume. However, small vessel disease (SVD) is currently established as serious comorbidity in dementia and its preliminary stages. It is therefore important to examine SVD markers in addition to AD markers in older adults presenting with SCD. Read More

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January 2018
5 Reads

Patients with Acute Lacunar Infarction Have Benefit from Intravenous Thrombolysis.

J Stroke Cerebrovasc Dis 2018 Nov 5. Epub 2018 Nov 5.

University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; Clinic of Neurology, Clinical Centre of Vojvodina, Novi Sad, Serbia. Electronic address:

Introduction: Usefulness of intravenous thrombolysis in patients with acute lacunar cerebral infarction is questionable. The aim of this study was to evaluate the efficacy and safety of intravenous thrombolysis in patients with lacunar infarction in comparison with patients with nonlacunar infarction as well as with patients with lacunar infarction who were not treated with intravenous thrombolysis.

Materials And Methods: In the first part of the study, among patients with acute ischemic stroke treated with intravenous thrombolysis, characteristics and outcomes of 46 patients with lacunar and 221 patients with nonlacunar infarction were compared. Read More

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November 2018
5 Reads

The Impact of Covert Lacunar Infarcts and White Matter Hyperintensities on Cognitive and Motor Outcomes After Stroke.

J Stroke Cerebrovasc Dis 2018 Nov 5. Epub 2018 Nov 5.

Department of Physical Therapy, University of British Columbia, Vancouver, Canada. Electronic address:

Background And Aims: In addition to overt stroke lesions, co-occurring covert lesions, including white matter hyperintensities (WMH) and covert lacunar infarcts (CLI), contribute to poststroke outcome. The purpose of this study was to examine the relationship between covert lesions, and motor and cognitive outcomes in individuals with chronic stroke.

Methods: Volumetric quantification of clinically overt strokes, covert lesions (periventricular and deep: pWMH, dWMH, pCLI, dCLI), ventricular and sulcal CSF (vCSF, sCSF), and normal appearing white (NAWM) and gray matter (NAGM) was performed using structural magnetic resonance imaging. Read More

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November 2018
7 Reads

The disuse effect on canal network structure and oxygen supply in the cortical bones of rats.

Biomech Model Mechanobiol 2018 Nov 1. Epub 2018 Nov 1.

Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan.

In this study, based on the measurements of intracortical vascular canal structure, we investigated the disuse effect on local O supply in the cortical bones of growing rats. Hindlimb disuse was produced by unilateral sciatic neurectomy (SN) at 4 weeks age. The canal network structures within tibial cortical bone were evaluated in 8- and 12-week-old rats undergoing SN or no treatment (control) by synchrotron radiation micro-CT. Read More

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November 2018
2 Reads

Silent Cerebral Infarctions with Reduced, Mid-Range and Preserved Ejection Fraction in Patients with Heart Failure.

Arq Bras Cardiol 2018 Sep;111(3):419-422

Ambulatório de Cardiomiopatias e Insuficiência Cardíaca - Universidade Federal da Bahia, Salvador, BA - Brazil.

Heart failure predisposes to an increased risk of silent cerebral infarction, and data related to left ventricular ejection fraction are still limited. Our objective was to describe the clinical and echocardiographic characteristics and factors associated with silent cerebral infarction in patients with heart failure, according to the left ventricular ejection fraction groups. A prospective cohort was performed at a referral hospital in Cardiology between December 2015 and July 2017. Read More

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September 2018
1 Read
1.120 Impact Factor

Vascular Pathology Causing Late Onset Generalized Chorea: A Clinico-Pathological Case Report.

Mov Disord Clin Pract 2017 Nov-Dec;4(6):819-823. Epub 2017 Sep 8.

Department of Neurology Centro Hospitalar do Porto Porto Portugal.

Background: Chorea may occur as a manifestation of an acute stroke. Patients with vascular-related chorea typically present with an acute or subacute onset of hemichorea, contralateral to the lesion.

Methods And Findings: In this clinico-pathological case, we report a 90-year-old female who presented, at age 81, with a transient episode of generalized chorea. Read More

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September 2017
8 Reads

Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct.

J Clin Periodontol 2018 Oct 26. Epub 2018 Oct 26.

Periodontology Unit, Faculty of Medicine and Odontology, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.

Aim: To investigate the association between periodontitis (PD) and lacunar infarct (LI) as well as to analyse whether PD could be a predictor of poor functional prognosis in patients with LI.

Material And Methods: Full-mouth periodontal examination was done in 120 cases (patients with LI) and 157 healthy controls. Demographic, clinical, medical and neurological information were collected from all of them. Read More

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October 2018
2 Reads

Automated approach for detection of ischemic stroke using Delaunay Triangulation in brain MRI images.

Comput Biol Med 2018 Dec 16;103:116-129. Epub 2018 Oct 16.

School of Electronics Engineering, KIIT Deemed to be University, Odisha, India. Electronic address:

It is difficult to develop an accurate algorithm to detect the stroke lesions using magnetic resonance imaging (MRI) images due to variation in different lesion sizes, variation in morphological structure, and similarity in intensity of lesion with normal brain in three types of stroke, namely partial anterior circulation syndrome (PACS), lacunar syndrome (LACS) and total anterior circulation stroke (TACS). In this paper, we have integrated the advantages of Delaunay triangulation (DT) and fractional order Darwinian particle swarm optimization (FODPSO), called DT-FODPSO technique for automatic segmentation of the structure of the stroke lesion. The approach was validated on 192 MRI images obtained from different stroke subjects. Read More

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December 2018
5 Reads

C-Reactive Protein, Plasma Amyloid-β Levels, and Their Interaction With Magnetic Resonance Imaging Markers.

Stroke 2018 Nov;49(11):2692-2698

Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, the Netherlands.

Background and Purpose- Inflammation is involved in the pathogenesis of large artery atherosclerosis, ischemic stroke, and Alzheimer dementia. However, the role of inflammation in cerebral small vessel disease and neurodegeneration remains poorly understood. We hypothesize that CRP (C-reactive protein) is associated with brain structural changes and may interact with amyloid to produce vascular and degenerative damage. Read More

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November 2018
2 Reads

Prediabetes Is Associated With Structural Brain Abnormalities: The Maastricht Study.

Diabetes Care 2018 Dec 16;41(12):2535-2543. Epub 2018 Oct 16.

Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands.

Objective: Structural brain abnormalities are key risk factors for brain diseases, such as dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain abnormalities already occur in prediabetes. Therefore, we investigated whether both prediabetes and type 2 diabetes are associated with lacunar infarcts (LIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and brain atrophy. Read More

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December 2018
2 Reads

Is hyperhomocysteinemia associated with the structural changes of the substantia nigra in Parkinson's disease? A two-year follow-up study.

Parkinsonism Relat Disord 2018 Oct 5. Epub 2018 Oct 5.

Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, People's Republic of China.

Objective: It was recently found that structural changes in the substantia nigra (SN) and motor symptoms become more prominent in Parkinson's disease (PD) patients with striatal silent lacunar infarction (SSLI) than in those without SSLI. Hyperhomocysteinemia (HHCY) was an independent risk factor for SSLI in PD patients. In this follow-up study, we investigated the relationship between HHCY and structural changes of the SN in PD patients. Read More

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October 2018
2 Reads

The role of clinical and neuroimaging features in the diagnosis of CADASIL.

J Neurol 2018 Dec 11;265(12):2934-2943. Epub 2018 Oct 11.

Neurology Unit, Department of Neuroscience and Sensory Organs, Maggiore Policlinico Hospital Foundation IRCCS Ca' Granda, Milan, Italy.

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common familial cerebral small vessel disease, caused by NOTCH3 gene mutations. The aim of our study was to identify clinical and neuroradiological features which would be useful in identifying which patients presenting with lacunar stroke and TIA are likely to have CADASIL.

Methods: Patients with lacunar stroke or TIA were included in the present study. Read More

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December 2018
3 Reads
3.380 Impact Factor

Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies.

J Stroke 2018 Sep 30;20(3):302-320. Epub 2018 Sep 30.

Stroke Monitoring Division, AtheroPoint, Roseville, CA, USA.

Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain hemorrhages and is a leading cause of cognitive decline and functional loss in elderly patients. Based on underlying pathophysiology, cSVD can be subdivided into amyloidal and non-amyloidal subtypes. Genetic factors of cSVD play a pivotal role in terms of unraveling molecular mechanism. Read More

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September 2018
1 Read

Identification of candidates for PFO closure in the echocardiography laboratory.

Echocardiography 2018 11 10;35(11):1860-1867. Epub 2018 Oct 10.

Division of Cardiovascular Diseases, Department of Medicine, University of Mississippi School of Medicine, Jackson, Mississippi.

A patent foramen ovale (PFO) is implicated in several pathologic processes, including that of cryptogenic stroke (cCVA). Recent trials identify "high-risk" PFOs in patients with cCVA as likely to benefit from percutaneous closure. The younger the patient (<60 years old) the more likely a PFO may be attributable to the cCVA. Read More

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November 2018
6 Reads

Different Mechanisms of Two Subtypes of Perforating Artery Infarct in the Middle Cerebral Artery Territory: A High-Resolution Magnetic Resonance Imaging Study.

Front Neurol 2018 20;9:657. Epub 2018 Sep 20.

Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Perforating Artery Infarcts (PAIs) can be divided into two subtypes based on their etiologies: branch Atheromatous Disease (BAD) and Lacunar Infarct (LI). Recent studies have shown that while both subtypes can be caused by large artery lesions, the different mechanisms that underlie their development are not clear. This study was designed to use High-Resolution Magnetic Resonance Imaging (HRMRI) to explore the differences that contribute to the occurrence of these two subtypes in large artery lesions in the anterior circulation. Read More

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September 2018
1 Read

Recurrent cerebral microbleeds with acute stroke symptoms: A case report.

Medicine (Baltimore) 2018 Sep;97(39):e12480

Department of Neurology, Chonbuk National University School of Medicine and Hospital, Jeonju, South Korea.

Rationale: Cerebral microbleeds are lesions that appear as round low signal intensity areas with a diameter of 2-5 mm on gradient echo T2-weighted sequence magnetic resonance imaging. Cerebral microblees are hemorrhages found in the brain parenchyma and they are caused by the extravasation of the blood. Although more patients with ischemic stroke are found to have cerebral microbleeds, only a few studies have evaluated other neurologic abnormalities outside of cognitive dysfunction due to cerebral microbleeds. Read More

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September 2018
2 Reads

Gradual common carotid artery occlusion as a novel model for cerebrovascular Hypoperfusion.

Metab Brain Dis 2018 Dec 28;33(6):2039-2044. Epub 2018 Sep 28.

One Medical Center Drive, West Virginia University, Morgantown, WV, 26506, USA.

Chronic cerebrovascular hypoperfusion results in vascular dementia and increases predisposition to lacunar infarcts. However, there are no suitable animal models. In this study, we developed a novel model for chronic irreversible cerebral hypoperfusion in mice. Read More

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December 2018
6 Reads

A study of intracortical porosity's area fractions and aspect ratios using computer vision and pulse-coupled neural networks.

Med Biol Eng Comput 2018 Sep 28. Epub 2018 Sep 28.

Department of Mechanical Engineering, American University of Beirut, Riad El-Solh, Beirut, 1107 2020, Lebanon.

Employing computer vision (CV) and optimized pulse-coupled neural networks (PCNN), this work automatically quantifies the geometrical attributes of intracortical bone porosity (namely lacunae and canaliculi (L-C), Haversian canals, and resorption cavities). Fifty pathological slides of cortical bone (× 20 magnification) were prepared from middiaphysis of bovine forelegs collected fresh from butcher. Biopsies were subdivided into sectors encircling arcs (θ of 10°) and radial distances (R) originating from the bone's geometric center toward posterior regions and spanning 3. Read More

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September 2018
4 Reads

Lacunar.

Authors:
Avraham Z Cooper

J Gen Intern Med 2018 Dec;33(12):2256

Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.

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December 2018

Examining the influence of PTH(1-34) on tissue strength and composition.

Bone 2018 Dec 24;117:130-137. Epub 2018 Sep 24.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

The lacunar-canaliculi system is a network of channels that is created and maintained by osteocytes as they are embedded throughout cortical bone. As osteocytes modify their lacuna space, the local tissue composition and tissue strength are subject to change. Although continual exposure to parathyroid hormone (PTH) can induce adaptation at the lacunar wall, the impact of intermittent PTH treatment on perilacunar adaptation remains unclear. Read More

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December 2018
6 Reads

Vertical Gaze Palsy Caused by Selective Unilateral Rostral Midbrain Infarction.

Neuroophthalmology 2018 Oct 9;42(5):309-311. Epub 2018 Jan 9.

Division of Neurology, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

Vertical gaze palsy is rarely a neurological symptom, although it has been observed in some cases. Here, we report the case of a patient presenting with complete upward and downward gaze palsy. In this case, a small lesion in the left rostral midbrain was observed on diffusion-weighted magnetic resonance (MR) images, and the lesion was considered to cause the ocular symptom. Read More

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October 2018

Architecture of nanoscale ferroelectric domains in GaMoS.

J Phys Condens Matter 2018 Nov 26;30(44):445402. Epub 2018 Sep 26.

Institute of Applied Physics, Technische Universität Dresden, D-01062 Dresden, Germany.

Local-probe imaging of the ferroelectric domain structure and auxiliary bulk pyroelectric measurements were conducted at low temperatures with the aim to clarify the essential aspects of the orbitally driven phase transition in GaMoS, a lacunar spinel crystal that can be viewed as a spin-hole analogue of its GaVS counterpart. We employed multiple scanning probe techniques combined with symmetry and mechanical compatibility analysis to uncover the hierarchical domain structures, developing on the 10-100 nm scale. The identified domain architecture involves a plethora of ferroelectric domain boundaries and junctions, including primary and secondary domain walls in both electrically neutral and charged configurations, and topological line defects transforming neutral secondary walls into two oppositely charged ones. Read More

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November 2018
1 Read

Investigation of ischemic and demyelinating lesions by cerebral vasoreactivity based on transcranial Doppler sonography: a comparative study.

Neuropsychiatr Dis Treat 2018 11;14:2323-2328. Epub 2018 Sep 11.

Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Variations of cerebral blood flow in response to hypoxia and hyperoxia in different disease conditions can provide new insights into disease etiopathogenesis. This study aimed to determine the characteristics of cerebral vasoreactivity for ischemia and demyelination.

Materials And Methods: This case-control study included: 28 patients with lacunar infarctions verified by history, physical examination, and MRI; 28 age- and sex-matched healthy controls; 28 patients with relapsing-remitting multiple sclerosis (MS), based on McDonald criteria; and 28 age- and sex-matched healthy controls for the MS group. Read More

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September 2018
2 Reads

Antihypertensive Therapy in the Acute Phase of Lacunar Infarcts.

Med Sci Monit 2018 Sep 22;24:6688-6694. Epub 2018 Sep 22.

Department of Neurology, The First People's Hospital of Lianyungang City, Lianyungang, Jiangsu, China (mainland).

BACKGROUND The optimal medical regimen for managing hypertension during acute phase of lacunar infarcts has not yet been clarified in real world setting. The aim of this study was to evaluate blood pressure lowering regimens on neurological progression and clinical outcomes during the acute phase of lacunar infarcts. MATERIAL AND METHODS For this study, 411 patients with first-episode lacunar infarcts and hypertension within 24 hours of symptom onset were included. Read More

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September 2018
4 Reads

Microbleeds in fronto-subcortical circuits are predictive of dementia conversion in patients with vascular cognitive impairment but no dementia.

Neural Regen Res 2018 Nov;13(11):1913-1918

Faculty of Health Sciences, University of Macau, Macao SAR, China.

Cerebral small vessel disease (CSVD) is a common etiology of vascular cognitive impairment with no dementia (V-CIND). Studies have revealed that cerebral microbleeds (CMBs), a feature of CSVD, contribute to cognitive impairment. However, the association between CMBs and dementia conversion in individuals with V-CIND is still unclear. Read More

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November 2018
6 Reads
0.230 Impact Factor

Association of the genetic polymorphisms in immunoinflammatory microRNAs with risk of ischemic stroke and subtypes in an Iranian population.

J Cell Physiol 2018 Sep 19. Epub 2018 Sep 19.

Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Stroke is one of the most common type of cerebrovascular disease threatening human health and life with high mortality, disability, and morbidity. Ischemic stroke (IS) is determined to be a complex disease containing a group of heterogeneous disorders with various environmental and genetic risk factors. This study evaluated the polymorphisms of microRNAs involved in inflammatory routes leading to stroke in an Iranian population. Read More

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September 2018
1 Read

High risk of early neurological worsening of lacunar infarction.

Acta Neurol Scand 2018 Sep 19. Epub 2018 Sep 19.

Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Background And Purpose: We aimed to evaluate factors associated with neurological worsening among patients with lacunar or non-lacunar infarction admitted within 3 hours and between 3 and 24 hours after stroke onset.

Methods: All patients admitted to Haukeland university hospital between 2006 and 2016 with acute cerebral infarction on MRI and admission within 24 hours were included. Repeated National Institute of Health Stroke Scale (NIHSS) scoring was performed in all patients whenever possible. Read More

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September 2018
1 Read

Different Strokes: A management dilemma.

Sultan Qaboos Univ Med J 2018 May 9;18(2):e202-e207. Epub 2018 Sep 9.

Department of Medicine, Sultan Qaboos University Hospital, Muscat, Oman.

Stroke is a common medical emergency resulting from numerous pathophysiological mechanisms and with varied clinical manifestations; as such, the diagnosis of stroke requires diligent clinical assessment. When different stroke syndromes occur in the same patient, it may cause a dilemma in terms of diagnosis and management. This continuing medical education article describes an interesting patient with recurrent neurological events, highlighting the complex pathophysiological processes associated with cerebrovascular syndromes. Read More

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May 2018
2 Reads

Cerebral and Extracerebral Vasoreactivity in Patients With Different Clinical Manifestations of Cerebral Small-Vessel Disease: Data From the Significance of Hemodynamic and Hemostatic Factors in the Course of Different Manifestations of Cerebral Small-Vessel Disease Study.

J Ultrasound Med 2018 Sep 12. Epub 2018 Sep 12.

Clinic of Neurology.

Objectives: Endothelial dysfunction has been implicated in the pathogenesis of cerebral small-vessel disease (SVD). Little is known about the relationship between SVD and measures of endothelium-dependent vasodilatation and cerebral vasomotor reactivity. The aim of this study was to evaluate cerebral and extracerebral endothelial dysfunction in patients with different manifestations of SVD and to assess the relationship between endothelial dysfunction and radiologic markers of SVD. Read More

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September 2018
2 Reads

Screening for morbidly adherent placenta in early pregnancy.

Ultrasound Obstet Gynecol 2018 Sep 10. Epub 2018 Sep 10.

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.

Objective: To estimate the diagnostic accuracy of a two-stage strategy for early prediction of morbidly adherent placenta (MAP). In the first stage, at 11-13 weeks' gestation, women with low-lying placenta and history of uterine surgery are classified as being at high risk for MAP and, in the second stage, at 12-16 weeks, these high-risk pregnancies are assessed at a specialist MAP clinic.

Methods: This was a prospective study in women having an ultrasound scan at 11-13 weeks' gestation as a part of routine pregnancy care. Read More

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September 2018
13 Reads

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging.

Neurobiol Dis 2018 Sep 6. Epub 2018 Sep 6.

Department of Pathology, Medical School, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurosurgery, Medical School, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Accumulating evidence suggest that cerebral microvascular disease increases with advancing age and is associated with lacunar stroke, leukoaraiosis, vascular dementia and Alzheimer disease. Increased blood brain barrier (BBB) permeability/leakage takes "center stage" in ongoing age-related vascular/brain parenchymal injury. Although significant effort has been made in defining the gene mutations and risk factors involved in microvascular alterations in vascular dementia and Alzheimer disease, the intra- and intercellular pathogenic mechanisms responsible for vascular hyperpermeability are still largely unknown. Read More

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September 2018
6 Reads

sP- and sE-selectin in stroke patients with metabolic disorders.

Neurol Neurochir Pol 2018 Sep - Oct;52(5):599-605. Epub 2018 Aug 17.

Department of Pathophysiology and Clinical Immunology, Medical University of Lodz, Plac Hallera 1, 91-647 Lodz, Poland.

Background: Activation of platelets and endothelial cells plays an important role in the pathogenesis of atherosclerosis and thrombotic disorders. The aim of our study was to assess the relationship between the metabolic disorders and markers of platelet activity and vascular injury in patient with acute ischemic stroke.

Material And Methods: The study group consisted of 84 patients with acute non-lacunar ischemic stroke divided into four subgroups with: (1) normolipidemia and normoglycemia, (2) normolipidemia and hyperglycemia, (3) hyperlipidemia and normoglycemia, (4) hyperlipidemia and hyperglycemia. Read More

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August 2018
1 Read

Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Dec 2;27(12):3425-3435. Epub 2018 Sep 2.

Neurology Department, Hospital Universitario de Albacete (Albacete), Albacete, Spain.

Introduction And Goal: Lacunar stroke is defined as an <1.5 cm diameter infarct located in the territory of a perforating artery, that is not accessible for direct study using conventional imaging techniques. Diagnosis requires exclusion of other causes. Read More

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December 2018
1 Read