5,113 results match your criteria Lacunar Stroke
J Stroke Cerebrovasc Dis 2018 Nov 27. Epub 2018 Nov 27.
Stroke Center/Neurology Service of the Lausanne University Hospital, Switzerland.
Background: There are limited data comparing posterior (PC) and anterior (AC) circulation acute ischemic strokes (AIS). We aimed to identify specific features of PC and AC strokes regarding clinical, etiological, radiological, and outcome factors.
Methods: Patients from the Acute STroke Registry and Analysis of Lausanne, a prospective cohort of consecutive AIS, from years 2003 to 2008 were included. Read More
Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):462-468
Department of Cardiovascular Surgery, Istanbul Medeniyet University Medical Faculty, Istanbul, Turkey.
Introduction: The aim of this study was to determine the outcomes of patients developing ischemic stroke after coronary artery bypass grafting (CABG).
Methods: From March 2012 to January 2017, 5380 consecutive patients undergoing elective coronary surgery were analyzed. Ninety-five patients who developed ischemic strokes after on-pump coronary surgery were included in the study, retrospectively. Read More
Folia Neuropathol 2018 ;56(2):81-87
Introduction: The prevalence of dementia is increasing in our aging population. Because of the complexity of disease pathology, dementia classifications remain controversial. The present post-mortem study investigates whether there are age differences between dementia brains with a single pure neurodegenerative or cerebrovascular disease and those with mixed pathological features. Read More
Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(9. Vyp. 2):14-21
Research Institute of Cerebrovascular Pathology and Stroke, Pirogov Russian National Research Medical University, Moscow, Russia; Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Aim: To study an influence of polymorphic variants of hemostasis system genes on the risk of ischemic stroke (IS) in patients of the Slavic population under the age of 50 years.
Material And Methods: Ninety-two patients (19 women and 73 men), aged 18-50 years, were examined. The diagnosis of stroke was confirmed by neuroimaging (CT or MRI) in all patients. Read More
BMC Vet Res 2018 Nov 27;14(1):370. Epub 2018 Nov 27.
Departament of Pathology, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof Dr. Orlando Marques de Paiva, 87, São Paulo, 05508-270, Brazil.
Background: β-amyloid (Aβ) can accumulate in the brain of aged dogs, and within vessels walls, the disease is called cerebral amyloid angiopathy (CAA). In humans, Alzheimer's disease and CAA are strongly correlated with cerebrovascular disease. However, in dogs, this association has not been extensively studied yet. Read More
Neurol Res 2018 Nov 26:1-5. Epub 2018 Nov 26.
a Department of Neurology , ShengJing Hospital of China Medical University , Shenyang , Liaoning , P.R. China.
Background: Previous studies have shown the potential interactions between cerebrovascular diseases and microalbuminuria. However, the relationship between urine microalbumin and acute lacunar infarction caused by cerebral small vessel disease (CSVD) remains unknown.
Methods: The clinical data of 148 patients with acute lacunar infarction admitted to the Department of Neurology, Shengjing Hospital of China Medical University between April 2016 and April 2017 were analyzed. Read More
Sleep Med 2018 Jun 26;53:81-87. Epub 2018 Jun 26.
Department of Neurology, Methodist Neurological Institute, Prof. Neurology Weill Cornell Medical School, Houston, TX, USA. Electronic address:
Background: Recent studies have suggested that cerebral ischemic infarction may contribute to the development of restless legs syndrome (RLS). This study analyzed the clinical and radiological profiles of RLS with onset after acute lacunar infarction.
Methods: In this retrospective study we enrolled 244 consecutive patients with acute lacunar infarction between January 2012 and June 2014. Read More
J Clin Neurosci 2018 Dec 24;58:25-29. Epub 2018 Oct 24.
Department of Neuroradiology, Montreal Neurological Institute and Hospital, McGill University, 3801 rue University, Montreal H3A2B4, QC, Canada. Electronic address:
In order to evaluate the usefulness of presymptomatic MRI, we performed 3T brain MRI and Sanger gene sequencing in a proband with suspected but not confirmed CADASIL and her apparently asymptomatic father. The 35-year-old proband presented with migraine with visual aura. Brain MRI showed diffuse leukoencephalopathy, suggesting CADASIL. Read More
eNeurologicalSci 2018 Dec 30;13:14-17. Epub 2018 Oct 30.
Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Lacunar strokes account for about a fourth of all ischemic strokes. Pontine infarcts often present with stuttering symptoms, referred to as pontine warning syndrome (PWS). Patients presenting with fluctuating symptoms can appear to have rapidly improving symptoms and thus often go untreated despite the risk of recurrent deficits. Read More
Med Sci Monit 2018 Nov 18;24:8306-8314. Epub 2018 Nov 18.
Department of Orthodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, China (mainland).
BACKGROUND The aim of this study was to dynamically evaluate tooth movement, root resorption, and remodeling of alveolar bone using different forces to cause tooth movement in rats. MATERIAL AND METHODS 12-week-old male Sprague-Dawley rats were selected. Nickel-titanium (Ni-Ti) coil springs (20 g, 50 g, and 100 g forces) were placed for mesial movement of the left first maxillary molar teeth. Read More
J Neuroradiol 2018 Nov 12. Epub 2018 Nov 12.
Department of Pathology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari, Polo di Monserrato. ss. 554 Monserrato (Cagliari) 09045, Italy.
Purpose: To explore the association between presence of inflammatory cells in the carotid plaques surgically treated and brain MRI findings.
Material And Methods: Forty consecutive patients were prospectively analyzed. Brain MRI was performed with a 1. Read More
Vasc Med 2018 Nov 14:1358863X18806583. Epub 2018 Nov 14.
1 School of Medicine, Universidad Espíritu Santo-Ecuador, Guayaquil, Ecuador.
Information on the association between arterial stiffness and cerebral small vessel disease (cSVD) is limited and confined to white and Asian populations. More regional information is needed to confirm this association in different ethnic groups. Using the Atahualpa Project cohort, we aimed to assess whether the aortic pulse wave velocity (PWV) is associated with the total cSVD score, as well as with each of the neuroimaging signatures of cSVD, in a population of Amerindians living in rural Ecuador. Read More
Clin Interv Aging 2018 24;13:2127-2134. Epub 2018 Oct 24.
Department of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang City, Hebei, People's Republic of China,
Purpose: This study aims to investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative delirium (POD) in elderly patients with silent lacunar infarct and preliminarily to determine the relationship among TEAS, blood-brain barrier (BBB), neuroinflammation, and POD.
Patients And Methods: Sixty-four-old patients with silent lacunar infarct were randomly divided into two groups: group TEAS and control group (group C). Patients in the group TEAS received TEAS (disperse-dense waves; frequency, 2/100 Hz) on acupoints Hegu and Neiguan of both sides starting from 30 minutes before induction of anesthesia until the end of surgery, and the intensity was the maximum current that could be tolerated. Read More
J Periodontol 2018 Nov 12. Epub 2018 Nov 12.
Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Background: Periodontitis has been associated with lacunar infarct (LI), a type of cerebral small vessel disease. The objective of this study was to ascertain whether periodontitis is associated with increased circulating levels of systemic inflammation and endothelial dysfunction biomarkers in patients with LI.
Methods: One hundred twenty patients with LI and 120 healthy controls underwent a full-mouth periodontal examination. Read More
J Alzheimers Dis 2018 ;66(3):1283-1294
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI, USA.
Background: Research in older adults with subjective cognitive decline (SCD) has mainly focused on Alzheimer's disease (AD)-related MRI markers, such as hippocampal volume. However, small vessel disease (SVD) is currently established as serious comorbidity in dementia and its preliminary stages. It is therefore important to examine SVD markers in addition to AD markers in older adults presenting with SCD. Read More
J Stroke Cerebrovasc Dis 2018 Nov 5. Epub 2018 Nov 5.
University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; Clinic of Neurology, Clinical Centre of Vojvodina, Novi Sad, Serbia. Electronic address:
Introduction: Usefulness of intravenous thrombolysis in patients with acute lacunar cerebral infarction is questionable. The aim of this study was to evaluate the efficacy and safety of intravenous thrombolysis in patients with lacunar infarction in comparison with patients with nonlacunar infarction as well as with patients with lacunar infarction who were not treated with intravenous thrombolysis.
Materials And Methods: In the first part of the study, among patients with acute ischemic stroke treated with intravenous thrombolysis, characteristics and outcomes of 46 patients with lacunar and 221 patients with nonlacunar infarction were compared. Read More
J Stroke Cerebrovasc Dis 2018 Nov 5. Epub 2018 Nov 5.
Department of Physical Therapy, University of British Columbia, Vancouver, Canada. Electronic address:
Background And Aims: In addition to overt stroke lesions, co-occurring covert lesions, including white matter hyperintensities (WMH) and covert lacunar infarcts (CLI), contribute to poststroke outcome. The purpose of this study was to examine the relationship between covert lesions, and motor and cognitive outcomes in individuals with chronic stroke.
Methods: Volumetric quantification of clinically overt strokes, covert lesions (periventricular and deep: pWMH, dWMH, pCLI, dCLI), ventricular and sulcal CSF (vCSF, sCSF), and normal appearing white (NAWM) and gray matter (NAGM) was performed using structural magnetic resonance imaging. Read More
Biomech Model Mechanobiol 2018 Nov 1. Epub 2018 Nov 1.
Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan.
In this study, based on the measurements of intracortical vascular canal structure, we investigated the disuse effect on local O supply in the cortical bones of growing rats. Hindlimb disuse was produced by unilateral sciatic neurectomy (SN) at 4 weeks age. The canal network structures within tibial cortical bone were evaluated in 8- and 12-week-old rats undergoing SN or no treatment (control) by synchrotron radiation micro-CT. Read More
Arq Bras Cardiol 2018 Sep;111(3):419-422
Ambulatório de Cardiomiopatias e Insuficiência Cardíaca - Universidade Federal da Bahia, Salvador, BA - Brazil.
Heart failure predisposes to an increased risk of silent cerebral infarction, and data related to left ventricular ejection fraction are still limited. Our objective was to describe the clinical and echocardiographic characteristics and factors associated with silent cerebral infarction in patients with heart failure, according to the left ventricular ejection fraction groups. A prospective cohort was performed at a referral hospital in Cardiology between December 2015 and July 2017. Read More
Mov Disord Clin Pract 2017 Nov-Dec;4(6):819-823. Epub 2017 Sep 8.
Department of Neurology Centro Hospitalar do Porto Porto Portugal.
Background: Chorea may occur as a manifestation of an acute stroke. Patients with vascular-related chorea typically present with an acute or subacute onset of hemichorea, contralateral to the lesion.
Methods And Findings: In this clinico-pathological case, we report a 90-year-old female who presented, at age 81, with a transient episode of generalized chorea. Read More
J Clin Periodontol 2018 Oct 26. Epub 2018 Oct 26.
Periodontology Unit, Faculty of Medicine and Odontology, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.
Aim: To investigate the association between periodontitis (PD) and lacunar infarct (LI) as well as to analyse whether PD could be a predictor of poor functional prognosis in patients with LI.
Material And Methods: Full-mouth periodontal examination was done in 120 cases (patients with LI) and 157 healthy controls. Demographic, clinical, medical and neurological information were collected from all of them. Read More
Comput Biol Med 2018 Dec 16;103:116-129. Epub 2018 Oct 16.
School of Electronics Engineering, KIIT Deemed to be University, Odisha, India. Electronic address:
It is difficult to develop an accurate algorithm to detect the stroke lesions using magnetic resonance imaging (MRI) images due to variation in different lesion sizes, variation in morphological structure, and similarity in intensity of lesion with normal brain in three types of stroke, namely partial anterior circulation syndrome (PACS), lacunar syndrome (LACS) and total anterior circulation stroke (TACS). In this paper, we have integrated the advantages of Delaunay triangulation (DT) and fractional order Darwinian particle swarm optimization (FODPSO), called DT-FODPSO technique for automatic segmentation of the structure of the stroke lesion. The approach was validated on 192 MRI images obtained from different stroke subjects. Read More
Stroke 2018 Nov;49(11):2692-2698
Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, the Netherlands.
Background and Purpose- Inflammation is involved in the pathogenesis of large artery atherosclerosis, ischemic stroke, and Alzheimer dementia. However, the role of inflammation in cerebral small vessel disease and neurodegeneration remains poorly understood. We hypothesize that CRP (C-reactive protein) is associated with brain structural changes and may interact with amyloid to produce vascular and degenerative damage. Read More
Diabetes Care 2018 Dec 16;41(12):2535-2543. Epub 2018 Oct 16.
Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands.
Objective: Structural brain abnormalities are key risk factors for brain diseases, such as dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain abnormalities already occur in prediabetes. Therefore, we investigated whether both prediabetes and type 2 diabetes are associated with lacunar infarcts (LIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and brain atrophy. Read More
Parkinsonism Relat Disord 2018 Oct 5. Epub 2018 Oct 5.
Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, People's Republic of China.
Objective: It was recently found that structural changes in the substantia nigra (SN) and motor symptoms become more prominent in Parkinson's disease (PD) patients with striatal silent lacunar infarction (SSLI) than in those without SSLI. Hyperhomocysteinemia (HHCY) was an independent risk factor for SSLI in PD patients. In this follow-up study, we investigated the relationship between HHCY and structural changes of the SN in PD patients. Read More
J Neurol 2018 Dec 11;265(12):2934-2943. Epub 2018 Oct 11.
Neurology Unit, Department of Neuroscience and Sensory Organs, Maggiore Policlinico Hospital Foundation IRCCS Ca' Granda, Milan, Italy.
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common familial cerebral small vessel disease, caused by NOTCH3 gene mutations. The aim of our study was to identify clinical and neuroradiological features which would be useful in identifying which patients presenting with lacunar stroke and TIA are likely to have CADASIL.
Methods: Patients with lacunar stroke or TIA were included in the present study. Read More
J Stroke 2018 Sep 30;20(3):302-320. Epub 2018 Sep 30.
Stroke Monitoring Division, AtheroPoint, Roseville, CA, USA.
Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain hemorrhages and is a leading cause of cognitive decline and functional loss in elderly patients. Based on underlying pathophysiology, cSVD can be subdivided into amyloidal and non-amyloidal subtypes. Genetic factors of cSVD play a pivotal role in terms of unraveling molecular mechanism. Read More
Echocardiography 2018 Nov 10;35(11):1860-1867. Epub 2018 Oct 10.
Division of Cardiovascular Diseases, Department of Medicine, University of Mississippi School of Medicine, Jackson, Mississippi.
A patent foramen ovale (PFO) is implicated in several pathologic processes, including that of cryptogenic stroke (cCVA). Recent trials identify "high-risk" PFOs in patients with cCVA as likely to benefit from percutaneous closure. The younger the patient (<60 years old) the more likely a PFO may be attributable to the cCVA. Read More
Front Neurol 2018 20;9:657. Epub 2018 Sep 20.
Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Perforating Artery Infarcts (PAIs) can be divided into two subtypes based on their etiologies: branch Atheromatous Disease (BAD) and Lacunar Infarct (LI). Recent studies have shown that while both subtypes can be caused by large artery lesions, the different mechanisms that underlie their development are not clear. This study was designed to use High-Resolution Magnetic Resonance Imaging (HRMRI) to explore the differences that contribute to the occurrence of these two subtypes in large artery lesions in the anterior circulation. Read More
Medicine (Baltimore) 2018 Sep;97(39):e12480
Department of Neurology, Chonbuk National University School of Medicine and Hospital, Jeonju, South Korea.
Rationale: Cerebral microbleeds are lesions that appear as round low signal intensity areas with a diameter of 2-5 mm on gradient echo T2-weighted sequence magnetic resonance imaging. Cerebral microblees are hemorrhages found in the brain parenchyma and they are caused by the extravasation of the blood. Although more patients with ischemic stroke are found to have cerebral microbleeds, only a few studies have evaluated other neurologic abnormalities outside of cognitive dysfunction due to cerebral microbleeds. Read More
Metab Brain Dis 2018 Dec 28;33(6):2039-2044. Epub 2018 Sep 28.
One Medical Center Drive, West Virginia University, Morgantown, WV, 26506, USA.
Chronic cerebrovascular hypoperfusion results in vascular dementia and increases predisposition to lacunar infarcts. However, there are no suitable animal models. In this study, we developed a novel model for chronic irreversible cerebral hypoperfusion in mice. Read More
Med Biol Eng Comput 2018 Sep 28. Epub 2018 Sep 28.
Department of Mechanical Engineering, American University of Beirut, Riad El-Solh, Beirut, 1107 2020, Lebanon.
Employing computer vision (CV) and optimized pulse-coupled neural networks (PCNN), this work automatically quantifies the geometrical attributes of intracortical bone porosity (namely lacunae and canaliculi (L-C), Haversian canals, and resorption cavities). Fifty pathological slides of cortical bone (× 20 magnification) were prepared from middiaphysis of bovine forelegs collected fresh from butcher. Biopsies were subdivided into sectors encircling arcs (θ of 10°) and radial distances (R) originating from the bone's geometric center toward posterior regions and spanning 3. Read More
J Gen Intern Med 2018 Dec;33(12):2256
Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
Bone 2018 Dec 24;117:130-137. Epub 2018 Sep 24.
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:
The lacunar-canaliculi system is a network of channels that is created and maintained by osteocytes as they are embedded throughout cortical bone. As osteocytes modify their lacuna space, the local tissue composition and tissue strength are subject to change. Although continual exposure to parathyroid hormone (PTH) can induce adaptation at the lacunar wall, the impact of intermittent PTH treatment on perilacunar adaptation remains unclear. Read More
Neuroophthalmology 2018 Oct 9;42(5):309-311. Epub 2018 Jan 9.
Division of Neurology, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
Vertical gaze palsy is rarely a neurological symptom, although it has been observed in some cases. Here, we report the case of a patient presenting with complete upward and downward gaze palsy. In this case, a small lesion in the left rostral midbrain was observed on diffusion-weighted magnetic resonance (MR) images, and the lesion was considered to cause the ocular symptom. Read More
J Phys Condens Matter 2018 Nov 26;30(44):445402. Epub 2018 Sep 26.
Institute of Applied Physics, Technische Universität Dresden, D-01062 Dresden, Germany.
Local-probe imaging of the ferroelectric domain structure and auxiliary bulk pyroelectric measurements were conducted at low temperatures with the aim to clarify the essential aspects of the orbitally driven phase transition in GaMoS, a lacunar spinel crystal that can be viewed as a spin-hole analogue of its GaVS counterpart. We employed multiple scanning probe techniques combined with symmetry and mechanical compatibility analysis to uncover the hierarchical domain structures, developing on the 10-100 nm scale. The identified domain architecture involves a plethora of ferroelectric domain boundaries and junctions, including primary and secondary domain walls in both electrically neutral and charged configurations, and topological line defects transforming neutral secondary walls into two oppositely charged ones. Read More
Neuropsychiatr Dis Treat 2018 11;14:2323-2328. Epub 2018 Sep 11.
Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Purpose: Variations of cerebral blood flow in response to hypoxia and hyperoxia in different disease conditions can provide new insights into disease etiopathogenesis. This study aimed to determine the characteristics of cerebral vasoreactivity for ischemia and demyelination.
Materials And Methods: This case-control study included: 28 patients with lacunar infarctions verified by history, physical examination, and MRI; 28 age- and sex-matched healthy controls; 28 patients with relapsing-remitting multiple sclerosis (MS), based on McDonald criteria; and 28 age- and sex-matched healthy controls for the MS group. Read More
Med Sci Monit 2018 Sep 22;24:6688-6694. Epub 2018 Sep 22.
Department of Neurology, The First People's Hospital of Lianyungang City, Lianyungang, Jiangsu, China (mainland).
BACKGROUND The optimal medical regimen for managing hypertension during acute phase of lacunar infarcts has not yet been clarified in real world setting. The aim of this study was to evaluate blood pressure lowering regimens on neurological progression and clinical outcomes during the acute phase of lacunar infarcts. MATERIAL AND METHODS For this study, 411 patients with first-episode lacunar infarcts and hypertension within 24 hours of symptom onset were included. Read More
Neural Regen Res 2018 Nov;13(11):1913-1918
Faculty of Health Sciences, University of Macau, Macao SAR, China.
Cerebral small vessel disease (CSVD) is a common etiology of vascular cognitive impairment with no dementia (V-CIND). Studies have revealed that cerebral microbleeds (CMBs), a feature of CSVD, contribute to cognitive impairment. However, the association between CMBs and dementia conversion in individuals with V-CIND is still unclear. Read More
J Cell Physiol 2018 Sep 19. Epub 2018 Sep 19.
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Stroke is one of the most common type of cerebrovascular disease threatening human health and life with high mortality, disability, and morbidity. Ischemic stroke (IS) is determined to be a complex disease containing a group of heterogeneous disorders with various environmental and genetic risk factors. This study evaluated the polymorphisms of microRNAs involved in inflammatory routes leading to stroke in an Iranian population. Read More
Acta Neurol Scand 2018 Sep 19. Epub 2018 Sep 19.
Department of Neurology, Haukeland University Hospital, Bergen, Norway.
Background And Purpose: We aimed to evaluate factors associated with neurological worsening among patients with lacunar or non-lacunar infarction admitted within 3 hours and between 3 and 24 hours after stroke onset.
Methods: All patients admitted to Haukeland university hospital between 2006 and 2016 with acute cerebral infarction on MRI and admission within 24 hours were included. Repeated National Institute of Health Stroke Scale (NIHSS) scoring was performed in all patients whenever possible. Read More
Sultan Qaboos Univ Med J 2018 May 9;18(2):e202-e207. Epub 2018 Sep 9.
Department of Medicine, Sultan Qaboos University Hospital, Muscat, Oman.
Stroke is a common medical emergency resulting from numerous pathophysiological mechanisms and with varied clinical manifestations; as such, the diagnosis of stroke requires diligent clinical assessment. When different stroke syndromes occur in the same patient, it may cause a dilemma in terms of diagnosis and management. This continuing medical education article describes an interesting patient with recurrent neurological events, highlighting the complex pathophysiological processes associated with cerebrovascular syndromes. Read More
J Ultrasound Med 2018 Sep 12. Epub 2018 Sep 12.
Clinic of Neurology.
Objectives: Endothelial dysfunction has been implicated in the pathogenesis of cerebral small-vessel disease (SVD). Little is known about the relationship between SVD and measures of endothelium-dependent vasodilatation and cerebral vasomotor reactivity. The aim of this study was to evaluate cerebral and extracerebral endothelial dysfunction in patients with different manifestations of SVD and to assess the relationship between endothelial dysfunction and radiologic markers of SVD. Read More
Ultrasound Obstet Gynecol 2018 Sep 10. Epub 2018 Sep 10.
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Objective: To estimate the diagnostic accuracy of a two-stage strategy for early prediction of morbidly adherent placenta (MAP). In the first stage, at 11-13 weeks' gestation, women with low-lying placenta and history of uterine surgery are classified as being at high risk for MAP and, in the second stage, at 12-16 weeks, these high-risk pregnancies are assessed at a specialist MAP clinic.
Methods: This was a prospective study in women having an ultrasound scan at 11-13 weeks' gestation as a part of routine pregnancy care. Read More
Neurobiol Dis 2018 Sep 6. Epub 2018 Sep 6.
Department of Pathology, Medical School, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurosurgery, Medical School, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:
Accumulating evidence suggest that cerebral microvascular disease increases with advancing age and is associated with lacunar stroke, leukoaraiosis, vascular dementia and Alzheimer disease. Increased blood brain barrier (BBB) permeability/leakage takes "center stage" in ongoing age-related vascular/brain parenchymal injury. Although significant effort has been made in defining the gene mutations and risk factors involved in microvascular alterations in vascular dementia and Alzheimer disease, the intra- and intercellular pathogenic mechanisms responsible for vascular hyperpermeability are still largely unknown. Read More
Neurol Neurochir Pol 2018 Sep - Oct;52(5):599-605. Epub 2018 Aug 17.
Department of Pathophysiology and Clinical Immunology, Medical University of Lodz, Plac Hallera 1, 91-647 Lodz, Poland.
Background: Activation of platelets and endothelial cells plays an important role in the pathogenesis of atherosclerosis and thrombotic disorders. The aim of our study was to assess the relationship between the metabolic disorders and markers of platelet activity and vascular injury in patient with acute ischemic stroke.
Material And Methods: The study group consisted of 84 patients with acute non-lacunar ischemic stroke divided into four subgroups with: (1) normolipidemia and normoglycemia, (2) normolipidemia and hyperglycemia, (3) hyperlipidemia and normoglycemia, (4) hyperlipidemia and hyperglycemia. Read More
J Stroke Cerebrovasc Dis 2018 Dec 2;27(12):3425-3435. Epub 2018 Sep 2.
Neurology Department, Hospital Universitario de Albacete (Albacete), Albacete, Spain.
Introduction And Goal: Lacunar stroke is defined as an <1.5 cm diameter infarct located in the territory of a perforating artery, that is not accessible for direct study using conventional imaging techniques. Diagnosis requires exclusion of other causes. Read More
Transl Stroke Res 2018 Sep 4. Epub 2018 Sep 4.
Department of Neurology, Sir Run Run Shaw Hospital, Affiliated with School of Medicine, Zhejiang University, #3 Qingchun East Road, Hangzhou, 310016, Zhejiang, China.
There is no effective biological method to classify ischemic stroke subtypes. In this study, we first performed a systematical gene array study on serum microRNAs with different ischemic stroke subtypes including 13 normal control subjects (NCs) and 87 ischemic stroke (IS) patients including 23 cardioembolism (CARD), 26 large artery atherosclerosis (LAA), 27 lacunar infarct (LAC), and 11 stroke of undetermined etiology (SUE). Validation was performed by using an independent cohort of 20 NCs and 85 IS patients including 28 CARD, 23 LAA, 18 LAC, and 16 SUE. Read More
Medicine (Baltimore) 2018 Aug;97(35):e12088
Department of Cardiology, The First Affiliated Hospital of Guangdong Pharmaceutical University.
Plasma brain natriuretic peptide (BNP), a diagnostic marker of cardiovascular diseases, has been previously linked to cerebrovascular diseases. Our goal was to determine whether plasma BNP level is helpful for identifying high-risk individuals who are likely to present with the 3 main subtypes of cerebral small vessel diseases (CSVDs), namely, white matter lesions, lacunar infarcts, and cerebral microbleeds, on magnetic resonance imaging (MRI) in patients with hypertension.Three hundred forty-six consecutive hypertensive patients presenting at our cardiology or neurology clinic were investigated. Read More