3,732 results match your criteria Lactose Intolerance

Purified lactases versus whole-cell lactases-the winner takes it all.

Appl Microbiol Biotechnol 2021 Jun 11. Epub 2021 Jun 11.

National Food Institute, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark.

Lactose-free dairy products are in great demand worldwide due to the high prevalence of lactose intolerance. To make lactose-free dairy products, commercially available β-galactosidase enzymes, also termed lactases, are used to break down lactose to its constituent monosaccharides, glucose and galactose. In this mini-review, the characteristics of lactase enzymes, their origin, and ways of use are discussed in light of their potential for hydrolyzing lactose. Read More

View Article and Full-Text PDF

Determination of Carbohydrates in Lactose-Free Dairy Products to Support Food Labelling.

Foods 2021 May 28;10(6). Epub 2021 May 28.

Department of Health, Animal Science and Food Safety, University of Milan, Via Celoria 10, 20133 Milan, Italy.

Milk and its derivatives are the basis of human nutrition since childhood. Given their importance within a balanced diet, the determination of carbohydrates in milk and its derivatives is fundamental for two reasons: one of alimentary origin related to intolerances and the other one of technological origin, especially for PDO (Protected Designation of Origin) products. The dietetic approach, including lactose-free products, has a crucial role in the management of lactose intolerance, but labelling and compositional rules indicating the absence or reduced presence of lactose in food are currently not harmonised at Union level. Read More

View Article and Full-Text PDF

Blinded Oral Challenges with Lactose and Placebo Accurately Diagnose Lactose Intolerance: A Real-Life Study.

Nutrients 2021 May 13;13(5). Epub 2021 May 13.

Department of Clinical Medicine and Surgery, Gastroenterology, University Federico II of Naples, 80131 Naples, Italy.

Lactose intolerance (LI) is characterized by diarrhea, abdominal pain, or bloating occurring after lactose consumption in patients with lactose malabsorption. The National Institute of Health (NIH) proposed a double-blind placebo testing to identify LI individuals correctly. However, until now, no study used this approach in a real-life setting. Read More

View Article and Full-Text PDF

Lactose Intolerance in Pediatric Patients and Common Misunderstandings About Cow's Milk Allergy.

Pediatr Ann 2021 Apr 1;50(4):e178-e185. Epub 2021 Apr 1.

Lactose intolerance is a common gastrointestinal condition caused by the inability to digest and absorb dietary lactose. Primary lactose intolerance is the most common type of lactose intolerance. It is one of the most common forms of food intolerance and occurs when lactase activity is reduced in the brush border of the small bowel mucosa. Read More

View Article and Full-Text PDF

Prevalence of lactose intolerance and nutrients intake in an older population regarded as lactase non-persistent.

Clin Nutr ESPEN 2021 Jun 10;43:317-321. Epub 2021 Apr 10.

Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 176700, AA, Wageningen, the Netherlands.

Background And Aims: Energy and nutrient intakes of community-dwelling older adults in Indonesia are inadequate whereby milk consumption is among the lowest in the world. Lactose intolerance is probably one of the reasons for such low milk consumption, but information on the burden of this problem and its consequences for dietary intake is lacking. We obtained data on the prevalence of lactose intolerance and dietary intakes in Indonesian older outpatients, thereby comparing dairy users and non-dairy users. Read More

View Article and Full-Text PDF

Typical gut indigenous bacteria in ICR mice fed a soy protein-based normal or low-protein diet.

Curr Res Food Sci 2021 24;4:295-300. Epub 2021 Apr 24.

Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Among Konan, Minato-ku, Tokyo, 108-8477, Japan.

For patients with inflammatory bowel disease, cow's milk allergy, and lactose intolerance, soymilk is a potential alternative to cow's milk. In this study, we aimed to identify the effects of a soy protein-based low-protein diet on the body and organ weights and the gut microbiome of six-week-old mice fed a diet containing 20% (SP) or 5% (LP) soy protein for 14 days via 16S rRNA (V4) amplicon sequencing. Body weight gain (growth) and liver, spleen, and fat tissue weight were significantly suppressed by the LP diet. Read More

View Article and Full-Text PDF

'If relevant, yes; if not, no': General practitioner (GP) users and GP perceptions about asking ethnicity questions in Irish general practice: A qualitative analysis using Normalization Process Theory.

PLoS One 2021 12;16(5):e0251192. Epub 2021 May 12.

School of Medicine & Health Research Institute, University of Limerick, Limerick, Ireland.

Context: The use of ethnic identifiers in health systems is recommended in several European countries as a means to identify and address heath inequities. There are barriers to implementation that have not been researched.

Objective: This study examines whether and how ethnicity data can be collected in Irish general practices in a meaningful and acceptable way. Read More

View Article and Full-Text PDF

Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management.

Nutrients 2021 Apr 29;13(5). Epub 2021 Apr 29.

Agroscope, Federal Department of Economic Affairs, Education and Research EAER, 3003 Bern, Switzerland.

Recent discoveries in the "omics" field and the growing focus on preventive health have opened new avenues for personalized nutrition (PN), which is becoming an important theme in the strategic plans of organizations that are active in healthcare, food, and nutrition research. PN holds great potential for individual health optimization, disease management, public health interventions, and product innovation. However, there are still multiple challenges to overcome before PN can be truly embraced by the public and healthcare stakeholders. Read More

View Article and Full-Text PDF

Immobilization of β-galactosidase from Bacillus licheniformis for application in the dairy industry.

Appl Microbiol Biotechnol 2021 May 3;105(9):3601-3610. Epub 2021 May 3.

Multidisciplinary Research, Science and Technology Network (RMPCT), Faculty of Chemical Engineering, Federal University of Uberlândia, Av. Getúlio Vargas, 230, Centro, Patos de Minas, MG, 38700-126, Brazil.

The food industry has developed a wide range of products with reduced lactose to allow people with intolerance to consume dairy products. Although β-galactosidase has extensive applications in the food, pharma, and biotechnology industries, the enzymes are high-cost catalysts, and their use makes the process costly. Immobilization is a viable strategy for enzyme retention inside a reactor, allowing its reuse and application in continuous processes. Read More

View Article and Full-Text PDF

Ileal Lactase Expression Associates with Lactase Persistence Genotypes.

Nutrients 2021 Apr 17;13(4). Epub 2021 Apr 17.

Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland.

(1) Background: Lactose digestion depends on persistence genotypes (including rs4988235), the frequency of which exhibits broad geographical variability. However, little is known about the relationship between lactase () genotypes and intestinal expression of . We aimed to investigate ileal expression of depending on main genetic polymorphisms (rs4988235, rs3754689, rs3739022), age, sex, smoking status, body mass index (BMI), and the expression of other genes; (2) Methods: phenotype, array-based genotype, and ileal mucosal biopsy expression data were obtained from the CEDAR study; (3) Results: analyses included 196 healthy Europeans (53. Read More

View Article and Full-Text PDF

Milk and Dairy Products: Good or Bad for Human Bone? Practical Dietary Recommendations for the Prevention and Management of Osteoporosis.

Nutrients 2021 Apr 17;13(4). Epub 2021 Apr 17.

Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Osteoporosis affects women twice as often as men. Additionally, it is estimated that 0.3 million and 1. Read More

View Article and Full-Text PDF

The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia.

Microorganisms 2021 Apr 14;9(4). Epub 2021 Apr 14.

Fidia Farmaceutici S.p.A., R&D Unità locale Fidia Research sud, Contrada Pizzuta, 96017 Noto, Italy.

Bifidobacteria colonize the human gastrointestinal tract early on in life, their interaction with the host starting soon after birth. The health benefits are strain specific and could be due to the produced polysaccharides. The consumption of probiotics may prevent obesity, irritable bowel syndrome, eczema or atopic dermatitis, and asthma. Read More

View Article and Full-Text PDF

Lactose Intolerance Assessed by Analysis of Genetic Polymorphism, Breath Test and Symptoms in Patients with Inflammatory Bowel Disease.

Nutrients 2021 Apr 14;13(4). Epub 2021 Apr 14.

Gastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80131 Naples, Italy.

Many patients with inflammatory bowel disease (IBD) restrict dairy products to control their symptoms. The aim of the study was to investigate the prevalence of lactose intolerance assessed with hydrogen breath test (H-BT) in IBD patients in clinical remission compared to a sex, age and BMI matched control population. We further detected the prevalence of three single nucleotide polymorphisms of the lactase (LCT) gene: the lactase non persistence LCT-13910 CC (wildtype) and the intermediate phenotype LCT-22018 CT and LCT-13910 AG; finally, we assess the correlation between genotype and H-BT. Read More

View Article and Full-Text PDF

What Are the Pearls and Pitfalls of the Dietary Management for Chronic Diarrhoea?

Nutrients 2021 Apr 21;13(5). Epub 2021 Apr 21.

Department of Medicine, University of Otago, Christchurch 8140, New Zealand.

Chronic diarrhoea affects up to 14% of adults, it impacts on quality of life and its cause can be variable. Patients with chronic diarrhoea are presented with a plethora of dietary recommendations, often sought from the internet or provided by those who are untrained or inexperienced. In this review, we summarise the possible causes of chronic diarrhoea that can be managed by diet, the symptom improvement and quality of life benefits but also the potential risks of such dietary treatments. Read More

View Article and Full-Text PDF


Arq Gastroenterol 2021 Jan-Mar;58(1):26-31

Universidade Federal de São Paulo, Disciplina de Gastroenterologia, São Paulo, SP, Brasil.

Background: Worldwide, colorectal cancer (CRC) and gastric cancer (GC) are the third and the fifth most prevalent, respectively. Diarrhea is a common symptom in patients on chemotherapy or radiotherapy treatment and can reduce treatment tolerance. Surgical resections and chemotherapy change the intestinal microbiota that can lead to lactose intolerance, small intestinal bacterial overgrowth (SIBO). Read More

View Article and Full-Text PDF

Lactose intolerance: An update on its pathogenesis, diagnosis, and treatment.

Nutr Res 2021 May 21;89:23-34. Epub 2021 Mar 21.

ReGenera R&D International for Aging Intervention & San Babila Clinic, Milano, Italy. Electronic address:

Lactose intolerance has a high prevalence worldwide, ranging between 57% and 65%. It is caused by a reduction or loss of the activity of the intestinal enzyme lactase-phlorizin hydrolase, responsible for the digestion of lactose. This alteration determines an increased osmotic load in the small intestine and the fermentation of lactose by the bacterial flora, which leads to a high production of short-chain fatty acids and gas. Read More

View Article and Full-Text PDF

Colonic mucosal eosinophilia in children without inflammatory bowel disease.

Hum Pathol 2021 Apr 19;113:34-38. Epub 2021 Apr 19.

Children's Mercy, Division of Gastroenterology, Kansas City, MO, 64108, USA.

Children undergoing colonoscopy and mucosal biopsies may show increased colonic mucosal eosinophils, which may or may not be associated with inflammatory bowel disease. There is not much clinical data on American children who have isolated increased colonic mucosal eosinophils. We sought to study the clinical correlates of children without inflammatory bowel disease who show increased mucosal eosinophils to understand their clinical presentation, etiological associations, and outcome. Read More

View Article and Full-Text PDF

An algorithm for differentiating food antigen-related gastrointestinal symptoms.

Gastroenterol Hepatol Bed Bench 2021 ;14(1):8-16

Grigore T Popa" University of Medicine and Pharmacy, Iasi, Romania.

Aim: The aim of this clinical audit was to assess patient-reported outcomes on the effect of dietary intervention, to enhance our understanding of possible treatment options in irritable bowel syndrome (IBS).

Background: A large number of food-related gastro-intestinal disorders have been attributed to IBS for decades.

Methods: Patient-reported outcomes from the records of 149 IBS patients treated at secondary and tertiary Gastroenterology outpatients in two UK hospitals between January 2014 and July 2016 were audited. Read More

View Article and Full-Text PDF
January 2021

Non-responsive celiac disease in children on a gluten free diet.

World J Gastroenterol 2021 Apr;27(13):1311-1320

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, United States.

Background: Non-responsive celiac disease (NRCD) is defined as the persistence of symptoms in individuals with celiac disease (CeD) despite being on a gluten-free diet (GFD). There is scant literature about NRCD in the pediatric population.

Aim: To determine the incidence, clinical characteristics and underlying causes of NRCD in children. Read More

View Article and Full-Text PDF

Lactose Intolerance and Its Dietary Management: An Update.

J Am Coll Nutr 2021 Apr 8:1-11. Epub 2021 Apr 8.

Department of Food Technology and Nutrition, Lovely Professional University, Phagwara, India.

Milk is the most common food consumed worldwide and is also a major ingredient in the preparation of various dairy products. However, despite the high production and consumption of milk and milk-based products, there is a large percent of the world's population that suffer from allergies to milk solids and lactose intolerance. Lactose intolerance specifically means the inability of the body to breakdown the sugar to its simplest form for assimilation and it is due to the inefficiency or lack of the enzyme in the human body. Read More

View Article and Full-Text PDF

Does faecal calprotectin increase may be linked to lactose intolerance in patients with irritable bowel syndrome?

Minerva Gastroenterol (Torino) 2021 Apr 8. Epub 2021 Apr 8.

Gastroenterology Unit, North Hospital, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.

Background: Irritable bowel syndrome (IBS) is a multifactorial condition without any specific investigation. Faecal calprotectin (FC) may be elevated in IBS without any explanation. In addition, some patients with IBS have symptoms related to lactose intolerance. Read More

View Article and Full-Text PDF

Hydrogen Breath Tests: Are They Really Useful in the Nutritional Management of Digestive Disease?

Nutrients 2021 Mar 17;13(3). Epub 2021 Mar 17.

Gastroenterology Unit, Brotzu Hospital, 09121 Cagliari, Italy.

Background: Carbohydrate malabsorption is a frequent digestive problem associated with abdominal pain, bloating and diarrhea. Hydrogen breath testing (BT) represents the most reliable and validated diagnostic technique. The aim of this manuscript was to clarify the usefulness of BTs in the nutritional management of these disorders. Read More

View Article and Full-Text PDF

50 Years Ago in TheJournalofPediatrics: The Wind of Change in Lactose Malabsorption Diagnostics: From Invasive Tolerance Tests to Hydrogen Breath Tests.

Michelle Saad

J Pediatr 2021 04;231:161

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

View Article and Full-Text PDF

Current trends in non-dairy based synbiotics.

Crit Rev Biotechnol 2021 Mar 21:1-18. Epub 2021 Mar 21.

Department of Chemical Engineering, VNIT, Nagpur, India.

Probiotics provide many beneficial effects to the human body. Traditionally, food products used to deliver bacterial cells are fermented dairy products, among which yogurt is the most common. However, many people suffer from lactose intolerance and indigestion, who need nutrients from non-dairy products without using animal proteins. Read More

View Article and Full-Text PDF

The effect of yogurt fortified with and . probiotic in patients with lactose intolerance.

Food Sci Nutr 2021 Mar 20;9(3):1704-1711. Epub 2021 Jan 20.

Student Research Committee Shiraz University of Medical Sciences Shiraz Iran.

This study assessed the effect of probiotic yogurt fortified with and . in patients with lactose intolerance. Fifty-five patients suffering from lactose intolerance were randomly divided into control group of 28 lactose intolerance patients who received nonprobiotic yogurt (100 ml) and experimental group consisted of 27 lactose intolerance patients who received probiotic yogurt fortified (100 ml) with and . Read More

View Article and Full-Text PDF

L-T4 Therapy in Enteric Malabsorptive Disorders.

Front Endocrinol (Lausanne) 2021 23;12:626371. Epub 2021 Feb 23.

Department of Surgical, Medical and Molecular Pathology and Critical Care, University of Pisa, Pisa, Italy.

Levothyroxine (L-T4) absorption can be impaired by various causes: a) L-T4 ingestion during breakfast, or with food; b) conditions of reduced gastric acidity; c) intestinal procedures and diseases such as bariatric surgery, lactose intolerance (LI), celiac disease (CD), inflammatory bowel disease; d) drugs that alter L-T4 absorption, increasing the gastric pH, or preventing the dissolution of tablets. The development of new oral formulations, i.e. Read More

View Article and Full-Text PDF
February 2021

Stabilization of β-Galactosidase on Modified Gold Nanoparticles: A Preliminary Biochemical Study to Obtain Lactose-Free Dairy Products for Lactose-Intolerant Individuals.

Molecules 2021 Feb 25;26(5). Epub 2021 Feb 25.

Department of Biochemistry, School of Medicine, Batterjee Medical College for Sciences and Technology, Jeddah 21442, Saudi Arabia.

The unique chemical, optical, and electrical characteristics of nanoparticles make their utilization highly successful in every field of biological sciences as compared to their bulk counterpart. These properties arise as a result of their miniature size, which provides them an excellent surface area-to-volume ratio, inner structure, and shape, and hence increases their surface characteristics. Therefore, this study was undertaken to engineer gold nanoparticles (AuNPs) for improving their catalytic activity and stability in biotechnological processes. Read More

View Article and Full-Text PDF
February 2021

The self-management work of food hypersensitivity.

PLoS One 2021 5;16(3):e0248181. Epub 2021 Mar 5.

Department of Community Medicine, Norwegian Centre of Rural Medicine, UiT The Arctic University of Norway, Tromsø, Norway.

Background: Food hypersensitivity (FH) has received considerable attention in the scientific community in recent years. However, little attention has been given to the efforts people make to manage their FH. We aimed to explore these efforts by using Normalization Process Theory, which is a conceptual framework formerly used to describe the self-management 'work' of long-term conditions. Read More

View Article and Full-Text PDF

Comparing Response of Sheep and Cow Milk on Acute Digestive Comfort and Lactose Malabsorption: A Randomized Controlled Trial in Female Dairy Avoiders.

Front Nutr 2021 15;8:603816. Epub 2021 Feb 15.

The Liggins Institute, The University of Auckland, Auckland, New Zealand.

Sheep milk (SM) is a possible alternate dairy source for those who experience digestive symptoms with cow milk (CM). While both the milks contain lactose, one of the causes for self-reported intolerance to CM, the composition of SM and CM also differs across proteins and fats, which have been shown to impact digestive processes. To compare the acute digestive comfort and lactose malabsorption of SM to CM in female dairy avoiders. Read More

View Article and Full-Text PDF
February 2021