3,537 results match your criteria Lactose Intolerance


Assessment of lactase activity in humans by measurement of galactitol and galactonate in serum and urine after milk intake.

Am J Clin Nutr 2019 Feb;109(2):470-477

Agroscope, Federal Department of Economic Affairs, Education and Research, Bern, Switzerland.

Background: Lactase is an enzyme that hydrolyzes lactose into glucose and galactose in the small intestine, where they are absorbed. Hypolactasia is a common condition, primarily caused by genetic programming, that leads to lactose maldigestion and, in certain cases, lactose intolerance. Galactitol and galactonate are 2 products of hepatic galactose metabolism that are candidate markers for the intake of lactose-containing foods. Read More

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http://dx.doi.org/10.1093/ajcn/nqy296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367971PMC
February 2019
1 Read

[Ganglioneuroblastoma in a child with chronic abdominal pain - a case report].

Dev Period Med 2018 ;22(4):364-370

II Katedra i Klinika Pediatrii, Gastroenterologii i Żywienia, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Polska.

Chronic abdominal pain is a very common complaint in the population of children and adolescents. In most cases, the usual cause are functional gastrointestinal disorders. However, in a few percent of children, the reason for persistent chronic stomach pain are organic diseases occurring in the gastrointestinal tract, as well as parenteral diseases, including uro-genital tract abnormalities, inflammation of the lower respiratory tract and cancer processes. Read More

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January 2018
7 Reads

The First Report about the Laparoscopic Sleeve Gastrectomy-Induced Lactose Intolerance.

Obes Surg 2019 Jan 9. Epub 2019 Jan 9.

Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The impact of laparoscopic sleeve gastrectomy (LSG) on the lactose intolerance (LI) remains unclear. We checked 8 men and 34 women with mean body mass index (BMI) of 43.94 ± 5. Read More

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http://dx.doi.org/10.1007/s11695-018-03694-3DOI Listing
January 2019
3.747 Impact Factor

Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia.

JGH Open 2018 Dec 19;2(6):307-310. Epub 2018 Sep 19.

Department of Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia.

Background And Aims: There have been few reports on lactase deficiency (LD) and lactose intolerance (LI) in Malaysia, which has a peculiar mix of three distinct major Asian races-Malay, Chinese, and Indian. The aim of this study was to determine the prevalence of LD and LI in a young multiethnic Malaysian population.

Methods: Lactase activity was measured with a CO lactose breath test using an infrared spectrometer. Read More

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http://dx.doi.org/10.1002/jgh3.12089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308090PMC
December 2018

Dietary exclusion of fructose and lactose after positive breath tests improved rapid-transit constipation in children.

JGH Open 2018 Dec 14;2(6):262-269. Epub 2018 Aug 14.

Surgical Research Group Murdoch Children's Research Institute Parkville Victoria Australia.

Aims: Exclusion of ermentable ligosaccharides, isaccharides, onosaccharides, and olyols (FODMAPs) from the diet is effective in alleviating symptoms of irritable bowel syndrome (IBS) in adults. Rapid-transit constipation (RTC) is a recently discovered subset of chronic constipation and has been linked to food intolerance. The aim of this study was to audit the effect of specific FODMAP elimination diets in children with RTC. Read More

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http://dx.doi.org/10.1002/jgh3.12079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308069PMC
December 2018
1 Read

Use of a Novel Probiotic Formulation to Alleviate Lactose Intolerance Symptoms-a Pilot Study.

Probiotics Antimicrob Proteins 2019 Jan 7. Epub 2019 Jan 7.

Gastroenterology Laboratory and the Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, 39 Jabotinsky Street, 4941492, Petah Tikva, Israel.

Lactose intolerance is a common condition caused by lactase deficiency and may result in symptoms of lactose malabsorption (bloating, flatulence, abdominal discomfort, and change in bowel habits). As current data is limited, the aim of our study was to assess the efficacy of probiotics with a β-galactosidase activity on symptoms of lactose malabsorption and on the lactose hydrogen breath test (LHBT). The study group comprised eight symptomatic female patients with a positive LHBT. Read More

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http://dx.doi.org/10.1007/s12602-018-9507-7DOI Listing
January 2019
1 Read

Effect of metal ions present in milk on the structure and functional integrity of native and polyaniline chitosan nanocomposites bound β-galactosidase: A multi-spectroscopic approach.

Food Chem 2019 May 11;279:312-320. Epub 2018 Dec 11.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, U.P., India. Electronic address:

β-Galactosidase is vital to dairy industries because it catalyzes the hydrolysis of lactose into glucose and galactose making it useful for lactose intolerant patients to consume milk and its products. The present study demonstrates the effect of metal ions commonly found in milk, namely Zn, K, Ca and Mn on the activity of native and polyaniline chitosan nanocomposites bound Aspergillus oryzae β-galactosidase. In polyaniline chitosan silver nanocomposite adsorbed β-galactosidase, a multi-fold enhancement in catalytic activity was observed in the presence of cocktail of Zn, K, Ca and Mn ions. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.12.022DOI Listing
May 2019
1 Read

Inhibition of Maillard reactions by replacing galactose with galacto-oligosaccharides in casein model systems.

J Agric Food Chem 2018 Dec 24. Epub 2018 Dec 24.

Lactose reduced dairy products are more prone to Maillard reactions due to the presence of reactive monosaccharides. Conventional β-galactosidases, which are used for lactose hydrolysis in lactose reduced dairy products, will lead to conversion of lactose into glucose and galactose, where especially galactose is very reactive during Maillard reactions. Some β-galactosidases have transgalactosylating activity, and will thus convert lactose into galacto-oligosaccharides (GOS) and hereby limit the release of galactose. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b05565DOI Listing
December 2018
1 Read
2.912 Impact Factor

Lactose intolerance but not lactose maldigestion is more frequent in patients with irritable bowel syndrome than in healthy controls: A meta-analysis.

Neurogastroenterol Motil 2018 Dec 17:e13527. Epub 2018 Dec 17.

Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.

Background And Purpose: Irritable bowel syndrome (IBS) affects 10%-20% of the adult population and is characterized by abdominal symptoms without relevant organic disease. There are numerous clinical trials available investigating the relationship between IBS, lactose maldigestion (LM), and lactose intolerance (LI), but there have been no meta-analyses on this topic yet. We aimed to assess the prevalence of LM, objective and subjective (self-reported) LI in IBS patients compared to healthy controls (HC) without IBS. Read More

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http://dx.doi.org/10.1111/nmo.13527DOI Listing
December 2018

Lactose Intolerance, Dairy Avoidance, and Treatment Options.

Nutrients 2018 Dec 15;10(12). Epub 2018 Dec 15.

Department of Medicine, Division of Gastroenterology, Jewish General Hospital, McGill University School of Medicine, 3755 Cote St Catherine Rd, Room E110, Montreal, QC H3T 1E2, Canada.

Lactose intolerance refers to symptoms related to the consumption of lactose-containing dairy foods, which are the most common source for this disaccharide. While four causes are described, the most common is the genetically-determined adult onset lactose maldigestion due to loss of intestinal lactase governed by control of the gene by a 14,000 kb promoter region on chromosome 2. Gastrointestinal symptoms from lactose have expanded to include systemic effects and have also been confounded by other food intolerances or functional gastrointestinal disorders. Read More

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http://www.mdpi.com/2072-6643/10/12/1994
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http://dx.doi.org/10.3390/nu10121994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316316PMC
December 2018
18 Reads

Gender, Age, Race and Lactose Intolerance: Is There Evidence to Support a Differential Symptom Response? A Scoping Review.

Nutrients 2018 Dec 11;10(12). Epub 2018 Dec 11.

Nutrition Science, Purdue University, West Lafayette, IN 47906, USA.

Research evaluating the relationship between lactose intolerance (LI) symptoms and age, gender and race is reviewed. An exhaustive search was conducted on the Google Scholar and PubMed databases. The evidence suggests that women, the elderly or specific racial groups are not more susceptible to LI, but rather dose, body size and genetic differences in lactase non-persistence (LNP) are the primary drivers of intolerance symptoms. Read More

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http://dx.doi.org/10.3390/nu10121956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316196PMC
December 2018

Lactose in processed foods: evaluating the availability of information regarding its amount.

Cien Saude Colet 2018 Dec;23(12):4119-4128

Curso de Nutrição e Metabolismo, Departamento de Ciências da Saúde, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo. Ribeirão Preto SP Brasil.

Patients with lactose intolerance, a high prevalence disease, should control the intake of food with lactose to avoid gastrointestinal symptoms. Since tolerance depends on the amount of lactose ingested, it is essential to discuss the availability of the amount of lactose information in processed foods, which is currently not mandatory. The study measured the availability of information on the amount of lactose on the labels of processed food that contained milk or lactose in the ingredient list. Read More

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http://dx.doi.org/10.1590/1413-812320182312.21992016DOI Listing
December 2018
10 Reads

Clinical Efficacy Of Lactase Enzyme Supplement In Infant Colic: A Randomised Controlled Trial.

J Pak Med Assoc 2018 Dec;68(12):1744-1747

Kharadar General Hospital, Karachi.

Objective: To determine the efficacy of lactase enzyme supplement in infant colic.

Methods: The double-blind randomised clinical trial was conducted from November 2014 to June 2017 at Kharadar General Hospital, Karachi, and comprised infants aged 0-6 months with infant colic, excessive crying lasting at least 3 hours a day on at least 3 days a week for at least 3 weeks. The subjects were randomised into intervention group A which received lactase enzyme Colibid, and placebo group B. Read More

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December 2018

Diet and the Role of Food in Common Gastrointestinal Diseases.

Med Clin North Am 2019 Jan;103(1):101-110

Department of Internal Medicine, University of Texas Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390-9151, USA.

Food plays an essential role in normal cellular processes; however, certain foods may also trigger or worsen certain disease states. This article focuses particularly on the role of food in common gastrointestinal and liver diseases, and discusses the current evidence that either supports or debunks common dietary recommendations. Nutrition topics discussed include the use of artificial sweetener for weight loss, avoidance of all dairy products in the setting of lactose intolerance, dietary recommendations for diverticular disease, and dietary management in cirrhotic patients with hepatic encephalopathy. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.08.008DOI Listing
January 2019
1 Read

Analysis of lactase in lactose intolerance supplements.

Biochem Mol Biol Educ 2018 Nov;46(6):652-662

Department of Chemistry, College of Science, Technology, Engineering and Mathematics, Youngstown State University, Youngstown, Ohio.

Lactase is the enzyme responsible for the digestion of the disaccharide lactose, and deficiency in this enzyme causes the prevalent medical condition lactose intolerance. Management of lactose intolerance can be achieved through the administration of lactase supplements. Lactase is an appropriate platform for advanced enzymatic study because its medical application is a motivator for student learning. Read More

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http://dx.doi.org/10.1002/bmb.21185DOI Listing
November 2018
18 Reads

Protective effects of kefir against zearalenone toxicity mediated by oxidative stress in cultured HCT-116 cells.

Toxicon 2019 Jan 16;157:25-34. Epub 2018 Nov 16.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

Kefir is a fermented milk with numerous health favors counting restorative properties of bacterial flora, reduction of the symptoms of lactose intolerance, immune system stimulation, cholesterol reduction, as well as anti-mutagenic and anti-tumor properties. Zearalenone (ZEN) is a mycotoxin produced by some Fusarium species. ZEN often occurs as a contaminant in cereal grains and animal feeds. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183101
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http://dx.doi.org/10.1016/j.toxicon.2018.11.296DOI Listing
January 2019
12 Reads

Phase IV noninferiority controlled randomized trial to evaluate the impact on diagnostic thinking and patient management and the test-retest reproducibility of the Gaxilose test for hypolactasia diagnosis.

Medicine (Baltimore) 2018 Nov;97(46):e13136

Venter Pharma S.L. Alcobendas, Madrid.

Background: The diagnostic accuracy of the Gaxilose test (GT) for hypolactasia diagnosis has already been proved. The objectives of this clinical trial were to demonstrate the noninferiority of the GT compared to the hydrogen breath test (HBT) on the impact on diagnostic thinking and patient management, to evaluate the GT reproducibility with urine accumulated from 0 to 4 hours and from 0 to 5 hours and to assess test safety.

Methods: We conducted a randomized, parallel, noninferiority clinical trial. Read More

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http://dx.doi.org/10.1097/MD.0000000000013136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257416PMC
November 2018
1 Read

Recognizing the Leaky Gut as a Trans-diagnostic Target for Neuroimmune Disorders Using Clinical Chemistry and Molecular Immunology Assays.

Curr Top Med Chem 2018 ;18(19):1641-1655

Department of Psychiatry and Medical Psychology, Medical Faculty, Medical University of Plovdiv, Plovdiv, Bulgaria.

Background: Increased intestinal permeability with heightened translocation of Gramnegative bacteria, also known as "leaky gut", is associated with the pathophysiology of neuroimmune disorders, such as Major Depressive Disorder (MDD), Chronic Fatigue Syndrome (CSF) and (deficit) schizophrenia, as well as with general medical disorders, including irritable bowel syndrome. This review aims to summarize clinical biochemistry and molecular immunology tests that may aid in the recognition of leaky gut in clinical practice.

Methods: We searched online libraries, including PubMed/MEDLINE, Google Scholar and Scopus, with the key words "diagnosis" or "biomarkers" and "leaky gut", "bacterial translocation", and "intestinal permeability" and focused on papers describing tests that may aid in the clinical recognition of leaky gut. Read More

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http://dx.doi.org/10.2174/1568026618666181115100610DOI Listing
January 2018
15 Reads

Digestive side-effects with teriflunomide: Thoughts on lactose.

Rev Neurol (Paris) 2018 Dec 5;174(10):722-725. Epub 2018 Nov 5.

Centre de ressources et compétences SEP, neurologie, université Nice-Côte-d'Azur, CHU Pasteur 2, 30, voie Romaine, 06002 Nice, France.

Introduction: Teriflunomide, a novel, orally bioavailable, active metabolite of leflunomide, has anti-inflammatory activity. It is prescribed as a first-line treatment for relapsing-remitting multiple sclerosis (RRMS) at a dose of one 14mg tablet per day. Common adverse reactions observed in placebo-controlled trials with a frequency≥10% and a rate twofold or more than reported with placebo, include digestive disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00353787173068
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http://dx.doi.org/10.1016/j.neurol.2017.11.010DOI Listing
December 2018
20 Reads

Viability of on Fresh-Cut Chitosan and Alginate-Coated Apple and Melon Pieces.

Front Microbiol 2018 23;9:2538. Epub 2018 Oct 23.

Department of the Science of Agriculture, Food and Environment, University of Foggia, Foggia, Italy.

There is an increasing trend toward foods with probiotics; the awareness of healthy diet and wellbeing is the leading cause of this increase. As a result, food producers and stakeholders require new probiotic products. The increased incidence of lactose intolerance and the new lifestyles (vegan and vegetarian styles) have led to a renewed interest in non-dairy probiotic carriers. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205977PMC
October 2018
1 Read

Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on Current Management and Future Perspectives.

Nutrients 2018 Nov 1;10(11). Epub 2018 Nov 1.

Allergy Therapeutics Italia, via IV Novembre 76, 20190 Milano, Italy.

Milk is a fundamental component of the diet of every mammal; nevertheless, not every individual can tolerate this kind of food, especially in adulthood. However, lactose intolerance has only been recognized in the last 50 years, and currently, lactose intolerance is defined as a clinical syndrome characterized by pain, abdominal distention, flatulence, and diarrhoea that occur after lactose consumption. Lactose is currently a common disaccharide in human nutrition, both in breastfed infants and in adults, but its digestion requires a specialized enzyme called lactase. Read More

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http://www.mdpi.com/2072-6643/10/11/1599
Publisher Site
http://dx.doi.org/10.3390/nu10111599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265758PMC
November 2018
16 Reads

[Yogurt and dietary recommendations for lactose intolerance].

Nutr Hosp 2018 Sep 7;35(Spec No6):45-48. Epub 2018 Sep 7.

.

Malabsorption to lactose is caused by the inability to digest sugar due to the decrease in the activity of intestinal lactase. Malabsorption may be due to a primary or secondary disorder. Adult type primary hypolactasia is an autosomal recessive disorder, characterized by the progressive loss of lactase after weaning. Read More

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http://dx.doi.org/10.20960/nh.2287DOI Listing
September 2018
2 Reads

odifying ntestinal Integrity and icro iome in Severe Malnutrition with gume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial.

Wellcome Open Res 2018 2;3:95. Epub 2018 Aug 2.

Department of Paediatrics, Imperial College, London, W2 1PG, UK.

Changes in intestinal mucosal integrity and gut microbial balance occur in severe acute malnutrition (SAM), resulting in treatment failure and adverse clinical outcomes (gram-negative sepsis, diarrhoea and high case-fatality). Transient lactose intolerance, due to loss of intestinal brush border lactase, also complicates SAM, thus milk based feeds may not be optimal for nutritional rehabilitation. Since the gut epithelial barrier can be supported by short chain fatty acids, derived from microbiota fermentation by particular fermentable carbohydrates, we postulated that an energy-dense nutritional feed comprising of legume-based fermentable carbohydrates, incorporated with lactose-free versions of standard World Health Organization (WHO) F75/F100 nutritional feeds will enhance epithelial barrier function in malnourished children, reduce and promote resolution of diarrhoea and improve overall outcome. Read More

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https://wellcomeopenresearch.org/articles/3-95/v1
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http://dx.doi.org/10.12688/wellcomeopenres.14706.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171552PMC
August 2018
14 Reads

Prebiotics for Lactose Intolerance: Variability in Galacto-Oligosaccharide Utilization by Intestinal .

Nutrients 2018 Oct 16;10(10). Epub 2018 Oct 16.

Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, and UNC Microbiome Core, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

Lactose intolerance, characterized by a decrease in host lactase expression, affects approximately 75% of the world population. Galacto-oligosaccharides (GOS) are prebiotics that have been shown to alleviate symptoms of lactose intolerance and to modulate the intestinal microbiota, promoting the growth of beneficial microorganisms. We hypothesized that mechanisms of GOS utilization by intestinal bacteria are variable, impacting efficacy and response, with differences occurring at the strain level. Read More

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http://www.mdpi.com/2072-6643/10/10/1517
Publisher Site
http://dx.doi.org/10.3390/nu10101517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213946PMC
October 2018
14 Reads

Effects of Whole Milk Supplementation on Gut Microbiota and Cardiometabolic Biomarkers in Subjects with and without Lactose Malabsorption.

Nutrients 2018 Oct 2;10(10). Epub 2018 Oct 2.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

The aim of this study was to compare the impact of whole milk supplementation on gut microbiota and cardiometabolic biomarkers between lactose malabsorbers (LM) and absorbers (LA). We performed a pair-wise intervention study of 31 LM and 31 LA, 1:1 matched by age, sex, body mass index, and daily dairy intake. Subjects were required to add 250 mL/day whole milk for four weeks in their routine diet. Read More

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http://www.mdpi.com/2072-6643/10/10/1403
Publisher Site
http://dx.doi.org/10.3390/nu10101403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213503PMC
October 2018
5 Reads
3.150 Impact Factor

Cow's Milk Consumption and Health: A Health Professional's Guide.

J Am Coll Nutr 2018 Sep 24:1-12. Epub 2018 Sep 24.

a NFI-Nutrition Foundation of Italy , Milano , Italy.

The most recent scientific evidence supports the consumption of cow's milk and dairy products as part of a balanced diet. However, these days, the public and practicing physicans are exposed to a stream of inconsistent (and often misleading) information regarding the relationship between cow's milk intake and health in the lay press and in the media. The purpose of this article, in this context, is to facilitate doctor-patient communication on this topic, providing physicians with a series of structured answers to frequently asked patient questions. Read More

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http://dx.doi.org/10.1080/07315724.2018.1491016DOI Listing
September 2018
8 Reads

Review of the Clinical Experiences of Feeding Infants Formula Containing the Human Milk Oligosaccharide 2'-Fucosyllactose.

Nutrients 2018 Sep 21;10(10). Epub 2018 Sep 21.

Abbott Nutrition, Abbott Laboratories, Columbus, OH 43219, USA.

Human milk oligosaccharides (HMOs) are the third most abundant solid component in human milk after lactose and lipids. Preclinical research has demonstrated that HMOs and specifically 2'-fucosyllactose (2'-FL) are more than a prebiotic and have multiple functions, including immune, gut, and cognition benefits. Previously, human milk has been the only source for significant levels of HMOs. Read More

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http://dx.doi.org/10.3390/nu10101346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213476PMC
September 2018
8 Reads

Caries in children with lactose intolerance and cow's milk protein allergy.

Braz Oral Res 2018 17;32:e91. Epub 2018 Sep 17.

Department of Pediatric and Social Dentistry, School of Dentistry, Universidade Estadual Paulista - Unesp, Araçatuba, SP, Brazil.

Dental caries in 5-to-8-year-old children with cow's milk protein allergy (CMPA) and lactose intolerance (LI), their treatment needs, and the consumption of milk-based products and milk derivatives by these patients were investigated. A cross-sectional study was undertaken with 200 children in southern Brazil in 2017. The clinical examination was based on the World Health Organization criteria and a questionnaire was sent to parents or legal guardians to collect information on the children's food intake, pre-existing systemic diseases, medication use, and CMPA and LI. Read More

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http://dx.doi.org/10.1590/1807-3107bor-2018.vol32.0091DOI Listing
October 2018
5 Reads

Fatty acid specific δ13C values reveal earliest Mediterranean cheese production 7,200 years ago.

PLoS One 2018 5;13(9):e0202807. Epub 2018 Sep 5.

Department of Geosciences, The Pennsylvania State University, University Park, PA, United States of America.

The earliest evidence for cheese production in the Mediterranean is revealed by stable carbon isotope analyses of individual fatty acids in pottery residues from the Dalmatian coast of Croatia. Lipid residue data indicate the presence of milk in the earliest pottery, Impressed Ware, by 5700 cal. BCE (7700 BP). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202807PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124750PMC
February 2019
9 Reads

Spray congealed lipid microparticles for the local delivery of β-galactosidase to the small intestine.

Eur J Pharm Biopharm 2018 Nov 31;132:1-10. Epub 2018 Aug 31.

Department of Pharmacy and BioTechnology, PharmTech Lab, University of Bologna, Via S. Donato 19/2, 40127 Bologna, Italy.

Oral local delivery of therapeutic biologics is generally limited due to the multiple obstacles of the gastrointestinal (GI) tract, mainly represented by acidic stomach pH and digestive enzymes. In the present study, spray congealing was used to prepare solid lipid microparticles (SLMs) loaded with β-galactosidase (lactase), an enzyme used for the treatment of lactose intolerance, to achieve a local drug delivery to the small intestine. Lactase was characterized in terms of activity at different pH, kinetic parameters and proteolytic degradation by digestive enzymes. Read More

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http://dx.doi.org/10.1016/j.ejpb.2018.08.014DOI Listing
November 2018

Application of a commercial digestive supplement formulated with enzymes and probiotics in lactase non-persistence management.

Food Funct 2018 Sep;9(9):4642-4650

Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), C/Nicolás Cabrera, 9, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Strategies to avoid lactose malabsorption, which affects 70% of the world's population, are focused on the restriction of milk and dairy products or the use of non-human β-galactosidases or probiotics endowed with β-galactosidase activity added at mealtime. Our evaluation of a commercial blend of probiotics and enzymes (protease, lactase, lipase and amylase) and its potential application in lactase non-persistence management is described in this work. Recommended amounts (460-1000 mg) of the commercial probiotics-enzyme blend were shown to be adequate for performing in vitro lactose hydrolysis in standard solutions (0. Read More

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http://xlink.rsc.org/?DOI=C8FO01091A
Publisher Site
http://dx.doi.org/10.1039/c8fo01091aDOI Listing
September 2018
13 Reads

Allergy and Asthma: Food Allergies.

Authors:
Raj Mehta

FP Essent 2018 Sep;472:16-19

Florida Hospital Family Medicine Residency, 133 Benmore Drive, Winter Park, FL 32792.

Food allergies are immune-mediated allergic adverse reactions that occur after exposure to specific foods. The most commonly recognized food allergies are immunoglobulin E (IgE)-mediated reactions (eg, urticaria, angioedema, anaphylaxis) that result from exposure to milk, egg, peanut, tree nuts, shellfish, fish, wheat, or soy. However, other foods can cause food allergies. Read More

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September 2018
11 Reads

Association between increased plasma levels of homocysteine and depression observed in individuals with primary lactose malabsorption.

PLoS One 2018 23;13(8):e0202567. Epub 2018 Aug 23.

Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria.

Background: Current literature proposes associations between homocysteine (HCY), folic acid (FA), vitamin B12 metabolism and depression. However, the exact underlying biological mechanisms remain unclear. This study aimed at evaluating a possible link between primary adult-type lactose malabsorption (PALM), HCY, FA and vitamin B12 metabolism and depressive disorder. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202567PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107192PMC
February 2019
6 Reads

Weight bias in nutritional practice: a study with nutrition students.

Cad Saude Publica 2018 08 20;34(8):e00088017. Epub 2018 Aug 20.

Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brasil.

Obesity is associated with psychosocial problems like stigma, discrimination, and bias. Studies have found that nutritionists and nutrition students display negative attitudes and biases toward obese individuals. This study examined the existence of nutrition students' bias toward obese individuals. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0102-311X00088017DOI Listing
August 2018
11 Reads

Production of microhomologous-mediated site-specific integrated LacS gene cow using TALENs.

Theriogenology 2018 Oct 20;119:282-288. Epub 2018 Jul 20.

The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, Inner Mongolia Autonomous Region, 010018, PR China. Electronic address:

Gene editing tools (Zinc-Finger Nucleases, ZFN; Transcription Activator-Like Effector Nucleases, TALEN; and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas)9, CRISPR-Cas9) provide us with a powerful means of performing genetic engineering procedures. A combinational approach that utilizes both somatic cell nuclear transfer (SCNT) and somatic cell gene editing facilitates the generation of genetically engineered animals. However, the associated research has utilized markers and/or selected genes, which constitute a potential threat to biosafety. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093691X183050
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http://dx.doi.org/10.1016/j.theriogenology.2018.07.011DOI Listing
October 2018
19 Reads

Shen-ling-bai-zhu-san, a spleen-tonifying Chinese herbal formula, alleviates lactose-induced chronic diarrhea in rats.

J Ethnopharmacol 2019 Mar 31;231:355-362. Epub 2018 Jul 31.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. Electronic address:

Ethnopharmacological Relevance: Shen-ling-bai-zhu-san (SLBZS) was firstly documented in ancient Chinese medical works "Tai Ping Hui Min He Ji Ju Fang" in Song-dynasty. It has been widely used for treating gastrointestinal disorders such as diarrhea with poor appetite for about 900 years. The present study is to observe the effects of SLBZS on high lactose diet-induced chronic diarrhea. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183082
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http://dx.doi.org/10.1016/j.jep.2018.07.031DOI Listing
March 2019
62 Reads

[A global vision of adverse reactions to foods: food allergy and food intolerance].

Nutr Hosp 2018 Jun 12;35(Spec No4):102-108. Epub 2018 Jun 12.

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Over the last years, there has been an increase in adverse food reactions, probably associated with life style changes in the past decades. An adverse food reaction is any clinically abnormal response that can be attributed to ingestion, contact or inhalation of a food, its derivatives or an additive contained in it. They can be classified as food allergy or intolerance. Read More

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http://dx.doi.org/10.20960/nh.2134DOI Listing
June 2018
4 Reads

Physical health in children with neurodevelopmental disorders.

J Autism Dev Disord 2019 Jan;49(1):83-95

Center for Ethics, Law and Mental health (CELAM), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

With increasing numbers of children being diagnosed with neurodevelopmental disorders (NDDs) attention has been drawn to these children's physical health. We aimed to identify the prevalence of defined physical problems (epilepsy, migraine, asthma, cancer, diabetes, psoriasis, lactose intolerance, celiac disease, diarrhea, constipation, daytime enuresis, encopresis) in a nationwide population of 9- and 12-year-old twins subdivided into those with and without indications of NDDs. Parents of 28,058 twins participated in a well-validated telephone interview regarding their children's mental health and answered questions about their physical problems. Read More

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http://link.springer.com/10.1007/s10803-018-3697-4
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http://dx.doi.org/10.1007/s10803-018-3697-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331488PMC
January 2019
24 Reads

Cow milk protein allergy and other common food allergies and intolerances.

Paediatr Int Child Health 2018 Jul 17:1-9. Epub 2018 Jul 17.

a Department of Pediatrics, Faculty of Medicine , Mahidol University , Bangkok , Thailand.

The prevalence of food allergy and food intolerance is increasing and it is an important public health problem affecting children. Food allergy results from an immunological reaction to certain food(s) and affects numerous organs in the body. Food intolerances are non-immunological reactions including metabolic, toxic, pharmacological and undefined mechanisms. Read More

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http://dx.doi.org/10.1080/20469047.2018.1490099DOI Listing
July 2018
15 Reads

Post pancreatitis/cholecystectomy gluten intolerance.

Gastroenterol Hepatol Bed Bench 2018 ;11(3):273-275

Department of Gastroenterology, Hepatology and Nutrition, Milton Keynes University Hospital, United Kingdom.

This case report describes the journey of a patient who suffered from life-limiting gastrointestinal symptoms after an acute bout of pancreatitis following ERCP for cholelithiasis bile following a ductal stone, and subsequent cholecystectomy. She was diagnosed and treated for IBS with medication without significant improvement. On implementation of a simple gluten and lactose exclusion diet she recovered to her premorbid state, and trials of gluten challenge triggered flares of symptoms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040032PMC
January 2018
14 Reads

Does primary lactase deficiency reduce bone mineral density in postmenopausal women? A systematic review and meta-analysis.

Osteoporos Int 2018 Nov 16;29(11):2399-2407. Epub 2018 Jul 16.

Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 653, 84105, Beer-Sheva, Israel.

Postmenopausal osteoporosis is a significant cause of morbidity and mortality. The role of primary lactase deficiency (PLD) in its development is not clear. This meta-analysis showed that PLD is a risk factor for osteoporosis in postmenopausal women. Read More

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http://link.springer.com/10.1007/s00198-018-4635-1
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http://dx.doi.org/10.1007/s00198-018-4635-1DOI Listing
November 2018
14 Reads

Lactose malabsorption and intolerance: a review.

Food Funct 2018 Aug;9(8):4056-4068

Dpto. Nutrición y Bromatología II, Bromatología, Facultad de Farmacia. Universidad Complutense de Madrid, Spain.

Food lactose and lactose intolerance are today hot topics in the field of food and nutrition. About 70% of the adult world population is lactose-intolerant, due to low levels of intestinal lactase, also called lactase-phlorizin hydrolase (LPH), a β-d-galactosidase found in the apical surface of the intestinal microvilli. This may be due to the loss of intestinal lactase in adulthood, a condition transmitted by an autosomal recessive gene, which differs in humans according to race. Read More

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http://dx.doi.org/10.1039/c8fo00555aDOI Listing
August 2018
5 Reads

An Electronic Questionnaire Survey Evaluating the Perceived Prevalence and Practices of Lactose Intolerance in 1 to 5 Year Old Children in South East Asia.

Pediatr Gastroenterol Hepatol Nutr 2018 Jul 28;21(3):170-175. Epub 2018 Jun 28.

Department of Pediatrics, National University of Singapore, Singapore.

Purpose: Lactose intolerance (LI) is perceived to be frequent in Asia and has been reported to have considerable impact on dietary intake, nutritional status and the quality of life. We aimed to gather information from healthcare professionals on the perceived incidence, diagnosis and management of LI in 1 to 5 year old children in Southeast Asia.

Methods: An anonymous electronic survey was sent randomly among healthcare professionals registered in the database of the pediatric societies in Thailand, Indonesia, and Singapore between June and October 2016. Read More

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http://dx.doi.org/10.5223/pghn.2018.21.3.170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037798PMC
July 2018
4 Reads

Surface Display of Heterologous β-Galactosidase in Food-Grade Recombinant Lactococcus lactis.

Curr Microbiol 2018 Jun 19. Epub 2018 Jun 19.

Department of Microbiology, Third Military Medical University (Army Medical University), Chongqing, China.

β-Galactosidase is an essential enzyme for the metabolism of lactose in human beings and has an important role in the treatment of lactose intolerance (LI). β-Galactosidase expressed by intestinal microflora, such as lactic acid bacteria (LAB), also alleviates LI. A promising approach to LI management is to exploit a food-grade LAB delivery system that can inhabit the human intestine and overproduce β-galactosidase. Read More

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http://dx.doi.org/10.1007/s00284-018-1531-zDOI Listing
June 2018
14 Reads
1.423 Impact Factor

Comparison of Lactase Variant MCM6 -13910 C>T Testing and Self-report of Dairy Sensitivity in Patients With Irritable Bowel Syndrome.

J Clin Gastroenterol 2018 Jun 16. Epub 2018 Jun 16.

Enteric NeuroScience Program, Division of Gastroenterology and Hepatology.

Goals: To evaluate agreement of MCM6-13910 with self-report of dairy sensitivity (DS) and lactose hydrogen methane breath test (LHMBT) results in subjects with irritable bowel syndrome (IBS).

Background: IBS is a functional gastrointestinal disorder with symptoms including abdominal pain, variable bowel habits, and bloating. Adult patients with lactose malabsorption may present with similar symptoms. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295355PMC
June 2018
3 Reads

The Use of Complementary and Alternative Medicine Is Less Frequent in Patients with Inflammatory Bowel Disease Than in Patients with Other Chronic Gastrointestinal Disorders.

Gastroenterol Res Pract 2018 3;2018:9137805. Epub 2018 Apr 3.

First Department of Medicine, University of Szeged, Korányi fasor 8-10, Szeged 6720, Hungary.

Background And Aims: Complementary and alternative medicine (CAM) is commonly used among patients with inflammatory bowel diseases (IBD), but evidence about its real-life use is limited. We aimed to assess and compare CAM use in outpatients with IBD and other gastrointestinal diseases.

Materials And Methods: The use of herbs and botanicals, lifestyle modifications and mind/body therapies, patient satisfaction, and continuous use of conventional medicine were assessed with an anonymous questionnaire at a tertiary IBD unit in Hungary. Read More

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http://dx.doi.org/10.1155/2018/9137805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903339PMC
April 2018
7 Reads

Managing acute pain in patients who report lactose intolerance: the safety of an old excipient re-examined.

Ther Adv Drug Saf 2018 May 24;9(5):227-235. Epub 2018 Jan 24.

University of South Australia Division of Health Sciences, City East Campus, Corner Frome Rd and North Tce, Adelaide, South Australia, 5001, Australia.

Lactose intolerance is exceedingly common, reportedly affecting up to 70% of the world's population, leading to both abdominal and systemic symptoms. Current treatment focuses predominantly on restricting dietary consumption of lactose. Given lactose is one of the most commonly used excipients in the pharmaceutical industry, consideration must be given to the lactose content and therefore safety of pharmaceutical preparations prescribed for patients with lactose intolerance. Read More

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http://dx.doi.org/10.1177/2042098617751498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956952PMC
May 2018
15 Reads

Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia.

Nutrients 2018 May 1;10(5). Epub 2018 May 1.

Department of Medical Sciences, Section of Pediatrics, University of Ferrara, Via A. Moro 8, 44124 Ferrara, Italy.

Adult-type hypolactasia (ATH) is a clinical syndrome of primary lactase deficiency. A lactose-free diet is advisable to avoid the symptoms linked to the condition, but this potentially creates problems for optimal bone mineralization due to reduced calcium intake. To evaluate the effect of the lactose-free diet on the bone mineral status (BMS), we compared the phalangeal BMS of adolescents with ATH to that of peers on a normal diet. Read More

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http://www.mdpi.com/2072-6643/10/5/558
Publisher Site
http://dx.doi.org/10.3390/nu10050558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986438PMC
May 2018
4 Reads

Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials.

PLoS One 2018 30;13(4):e0194966. Epub 2018 Apr 30.

Department of Anthropology, Jagiellonian University, Cracow, Poland.

The relation of LCT-13910 genotypes and bone mineral density (BMD) has been the subject of modern-day human population studies, giving inconsistent results. In the present study we analyze for the first time a relation of LCT-13910 genotypes and BMD in historical skeletal individuals. Ancient population might be a model for testing this association due to elimination of non-natural factors affecting bone density. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194966PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927400PMC
July 2018
3.230 Impact Factor