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    Time-course evaluation of intestinal structural disorders in a porcine model of intra-abdominal hypertension by mechanical intestinal obstruction.
    PLoS One 2018 22;13(1):e0191420. Epub 2018 Jan 22.
    Department of General Surgery, Virgen de la Arrixaca General University Hospital, Murcia, Spain.
    Background: A mechanical intestinal obstruction (MIO) can generate intraabdominal hypertension (IAH) that is life threatening. The intestines are very sensitive to IAH since the low splanchnic perfusion causes intestinal hypoxia, local acidosis and bacterial translocations. This may lead to acute intestinal distress syndrome (AIDS). Read More

    Case 250: Alpers-Huttenlocher Syndrome.
    Radiology 2018 Feb;286(2):720-725
    From the Department of Radiology, University of Chicago, Pritzker School of Medicine, 5841 S Maryland Ave, Chicago, IL 60637.
    History A 10-year-old girl with global developmental delay and attention deficit hyperactivity disorder was transferred from an outside hospital because of confusion and multiple episodes of left face and arm jerking. Physical examination revealed normal muscle bulk, strength, and tone in the bilateral upper and lower extremities but insuppressible left arm and jaw twitching Lumbar puncture revealed no white or red blood cells, a normal glucose level of 55 mg/dL (3.0 mmol/L) (normal range, 50-80 mg/dL [2. Read More

    Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
    Neurogenetics 2018 Jan 19. Epub 2018 Jan 19.
    Research Programs Unit, Molecular Neurology, Biomedicum-Helsinki, University of Helsinki, Helsinki, Finland.
    Mutations in mitochondrial ATP synthase 6 (MT-ATP6) are a frequent cause of NARP (neurogenic muscle weakness, ataxia, and retinitis pigmentosa) or Leigh syndromes, especially a point mutation at nucleotide position 8993. M.8969G>A is a rare MT-ATP6 mutation, previously reported only in three individuals, causing multisystem disorders with mitochondrial myopathy, lactic acidosis, and sideroblastic anemia or IgA nephropathy. Read More

    Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis.
    Sci Rep 2018 Jan 18;8(1):1163. Epub 2018 Jan 18.
    RNA Modification and Mitochondrial Diseases Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Valencia, 46012, Spain.
    Human proteins MTO1 and GTPBP3 are thought to jointly catalyze the modification of the wobble uridine in mitochondrial tRNAs. Defects in each protein cause infantile hypertrophic cardiomyopathy with lactic acidosis. However, the underlying mechanisms are mostly unknown. Read More

    Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills.
    Endocrinol Diabetes Metab Case Rep 2018 5;2018. Epub 2018 Jan 5.
    Divisions of Endocrinology, Department of Medicine, Westchester Medical Center , Valhalla, New York, USA.
    Metformin is recommended as the first-line agent for the treatment of type 2 diabetes. Although this drug has a generally good safety profile, rare but potentially serious adverse effects may occur. Metformin-associated lactic acidosis, although very uncommon, carries a significant risk of mortality. Read More

    Targeting of stress response pathways in the prevention and treatment of cancer.
    Biotechnol Adv 2018 Jan 12. Epub 2018 Jan 12.
    Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic.. Electronic address:
    The hallmarks of tumor tissue are not only genetic aberrations but also the presence of metabolic and oxidative stress as a result of hypoxia and lactic acidosis. The stress activates several prosurvival pathways including metabolic remodeling, autophagy, antioxidant response, mitohormesis, and glutaminolysis, whose upregulation in tumors is associated with a poor survival of patients, while their activation in healthy tissue with statins, metformin, physical activity, and natural compounds prevents carcinogenesis. This review emphasizes the dual role of stress response pathways in cancer and suggests the integrative understanding as a basis for the development of rational therapy targeting the stress response. Read More

    The genotypic and phenotypic spectrum of MTO1 deficiency.
    Mol Genet Metab 2018 Jan 15;123(1):28-42. Epub 2017 Nov 15.
    Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, Vancouver, BC, Canada; BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada; Departments of Pediatrics and Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:
    Background: Mitochondrial diseases, a group of multi-systemic disorders often characterized by tissue-specific phenotypes, are usually progressive and fatal disorders resulting from defects in oxidative phosphorylation. MTO1 (Mitochondrial tRNA Translation Optimization 1), an evolutionarily conserved protein expressed in high-energy demand tissues has been linked to human early-onset combined oxidative phosphorylation deficiency associated with hypertrophic cardiomyopathy, often referred to as combined oxidative phosphorylation deficiency-10 (COXPD10).

    Material And Methods: Thirty five cases of MTO1 deficiency were identified and reviewed through international collaboration. Read More

    Efficacy and safety of long term entecavir therapy in a European population.
    Minerva Gastroenterol Dietol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Medical Sciences, University of Turin, Turin, Italy -
    Background: Therapy in chronic hepatitis B (CHB) patients aims at improving their survival by preventing disease progression to cirrhosis and its complications. Entecavir (ETV) is currently a first line therapeutic agent recommended for the treatment of CHB. Our aim was to evaluate the long term outcome of a cohort of CHB patients treated with ETV. Read More

    Expanding the phenotype of SLC25A42-associated mitochondrial encephalomyopathy.
    Clin Genet 2018 Jan 12. Epub 2018 Jan 12.
    Department of Genetics, King Faisal Specialist Hospital and Research Center. Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
    SLC25A42 gene encodes an inner mitochondrial membrane protein that imports Co-enzyme A (CoA) into the mitochondrial matrix. A mutation in this gene was recently reported in a subject born to consanguineous parents who presented with mitochondrial myopathy with muscle weakness and lactic acidosis. In this report, we present 12 additional individuals with the same founder mutation who presented with variable manifestations ranging from asymptomatic lactic acidosis to a severe phenotype characterized by developmental regression and epilepsy. Read More

    Lactate metabolism: historical context, prior misinterpretations, and current understanding.
    Eur J Appl Physiol 2018 Jan 10. Epub 2018 Jan 10.
    School of Kinesiology, Auburn University, 301 Wire Road, Auburn, AL, 36849, USA.
    Lactate (La-) has long been at the center of controversy in research, clinical, and athletic settings. Since its discovery in 1780, La- has often been erroneously viewed as simply a hypoxic waste product with multiple deleterious effects. Not until the 1980s, with the introduction of the cell-to-cell lactate shuttle did a paradigm shift in our understanding of the role of La- in metabolism begin. Read More

    Comparative assessment of probiotics and monensin in the prophylaxis of acute ruminal lactic acidosis in sheep.
    BMC Vet Res 2018 Jan 9;14(1). Epub 2018 Jan 9.
    Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, CEP, São Paulo, SP, 05508-270, Brazil.
    Background: Acute ruminal lactic acidosis (ARLA) is a major nutritional and metabolic disorder usually characterized by excessive or non-adapted intake of diets rich in nonstructural carbohydrates. Feed additives that regulate the ruminal environment have been used to prevent ARLA, such as ionophores and, more recently, yeast culture. Thus, we aimed to compare the efficacy of a yeast-based culture (Saccharomyces cerevisiae) with that of monensin sodium in the prevention of ARLA in sheep. Read More

    Lactic Acidosis and Mitral Valve Surgery: Defining the Relationship.
    J Cardiothorac Vasc Anesth 2017 Oct 2. Epub 2017 Oct 2.
    University Hospitals Birmingham NHS Foundation Trust, Department of Critical Care Medicine, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, United Kingdom; Perioperative Critical Care and Trauma Trials Group, Institute of Inflammation and Ageing Centre of Translational Inflammation Research, University of Birmingham, Birmingham, United Kingdom. Electronic address:

    Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients.
    Clin Toxicol (Phila) 2018 Jan 5:1-4. Epub 2018 Jan 5.
    h Emergency Department , Hamad General Hospital, Hamad Medical Corporation , Doha , Qatar.
    Importance: Acetaminophen toxicity is common and is characterized by hepatic failure. In cases that are not improving with standard medical therapy with N-acetylcysteine, some patients may require hepatic transplant. While there are various criteria to predict patients who might benefit from transplant, the King's College criteria remain one of the most widely used. Read More

    Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats.
    Blood Adv 2017 Jul 14;1(17):1296-1305. Epub 2017 Jul 14.
    Department of Biochemistry and Molecular Genetics.
    Red blood cells (RBCs) are the most abundant host cell in the human body and play a critical role in oxygen transport and systemic metabolic homeostasis. Hypoxic metabolic reprogramming of RBCs in response to high-altitude hypoxia or anaerobic storage in the blood bank has been extensively described. However, little is known about the RBC metabolism following hemorrhagic shock (HS), the most common preventable cause of death in trauma, the global leading cause of total life-years lost. Read More

    Type B lactic acidosis, an uncommon paraneoplastic syndrome.
    Cancer Biol Ther 2018 Feb 2;19(2):101-104. Epub 2018 Jan 2.
    b Department of Hematology/Oncology , Fox Chase Cancer Center , Philadelphia , PA.
    A 67-year-old male presented with anasarca and persistent non-pruritic rash of lower extremities. Physical examination was positive for subcutaneous edema with a non-blanching rash of abdomen and lower extremities. Labs showed leukocytosis, lymphocytosis, anemia and thrombocytopenia. Read More

    Bone marrow features in Pearson syndrome with neonatal onset: A case report and review of the literature.
    Pediatr Blood Cancer 2017 Dec 29. Epub 2017 Dec 29.
    Pediatric Hematology and Oncology Unit, Department of Pediatrics, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
    Pearson syndrome (PS) is a rare mitochondrial disorder that usually presents with transfusion-dependent macrocytic anemia, exocrine pancreatic dysfunction, and lactic acidosis. Typical bone marrow (BM) features are vacuolization in hematopoietic progenitors, hypocellularity, and ringed sideroblasts. At the neonatal age, PS may have a variable clinical onset. Read More

    Establishment of an Extracellular Acidic pH Culture System.
    J Vis Exp 2017 Nov 19(129). Epub 2017 Nov 19.
    Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo;
    Conditions of the tumor microenvironment, such as hypoxia or nutrient starvation, play critical roles in cancer progression and malignancy. However, the role of acidic extracellular pH in tumor aggressiveness and its underlying mechanism has not been extensively studied compared to hypoxic or nutrient starvation conditions. In addition, a well-defined culture method to mimic the acidic extracellular tumor microenvironment has not been fully reported. Read More

    Anemia was an Uncommon Complication of Severe Malaria in a High-Transmission Rural Area of Western Uganda.
    Am J Trop Med Hyg 2017 Dec 26. Epub 2017 Dec 26.
    Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.
    The clinical epidemiology of severe malaria among patients presenting to peripheral health centers has not been well described. We conducted a prospective, observational cohort study to describe the epidemiology and clinical manifestations of severe malaria in a highland area of declining transmission intensity in Western Uganda. Individuals presenting with a history of fever were screened with a malaria rapid diagnostic test (RDT). Read More

    Outcome of epilepsy in patients with mitochondrial disorders: Phenotype genotype and magnetic resonance imaging correlations.
    Clin Neurol Neurosurg 2017 Dec 9;164:182-189. Epub 2017 Dec 9.
    Dept. of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India; Neuromuscular lab-Neurobiology Research Centre, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India. Electronic address:
    Objectives: Studies exploring the outcome of epilepsy in patients with mitochondrial disorders are limited. This study examined the outcome of epilepsy in patients with mitochondrial disorders and its relation with the clinical phenotype, genotype and magnetic resonance imaging findings.

    Patients And Methods: The cohort was derived from the database of 67 patients with definite genetic diagnosis of mitochondrial disorders evaluated over a period of 11years (2006-2016). Read More

    Is Metformin Poised for a Second Career as an Antimicrobial?
    Diabetes Metab Res Rev 2017 Dec 22. Epub 2017 Dec 22.
    Laboratory of Diabetes and Diabetes-related Research, Feinstein Institute for Medical Research, Manhasset, NY, United States.
    Background: Metformin, a widely used anti-hyperglycemic, has a good safety profile, reasonably manageable side-effects, is inexpensive and causes a desirable amount of weight loss. In four studies of patients with tuberculosis (one prospective and three retrospective), metformin administration resulted in better outcomes. In mice with several models of endotoxemia, metformin diminished levels of pro-inflammatory cytokines and improved survival. Read More

    Lactate levels and risk of lactic acidosis with metformin in diabetic kidney disease patients.
    Saudi J Kidney Dis Transpl 2017 Nov-Dec;28(6):1356-1361
    Department of Nephrology, Medical College, Thiruvananthapuram, Kerala, India.
    Metformin as an oral antidiabetic drug (OAD) is not recommended in renal failure due to the presumed risk of lactic acidosis though it has advantages in cardiovascular protection with a low risk of hypoglycemia. Few studies have measured lactic acid blood levels in patients with diabetic kidney disease on metformin and demonstrated lactic acidosis. The aim of our study is to see if patients with diabetic kidney disease are at risk of elevated lactate blood levels and lactic acidosis. Read More

    Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically-relevant Concentrations in cultured Human HL-60 promyelocytes and THP-1 monocytes.
    Antimicrob Agents Chemother 2017 Dec 20. Epub 2017 Dec 20.
    Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium
    Linezolid, the first clinically-available oxazolidinone antibiotic, causes potentially severe toxicities (myelosuppression, lactic acidosis, neuropathies) ascribed to impairment of mitochondrial protein synthesis and consecutive mitochondrial dysfunction. Tedizolid, a newly approved oxazolidinone, shows an enhanced activity compared to linezolid but is also a more potent inhibitor of mitochondrial protein synthesis. We have compared linezolid and tedizolid for (i) inhibition of the expression of subunit I of cytochrome c-oxidase (CYTox I; Western blot analysis); (ii) cytochrome c-oxidase activity (biochemical assay), (iii) mitochondrial oxidative metabolism (Seahorse technology), and alteration of mitochondrial ultrastructure (electron microscopy) using HL-60 promyelocytes and THP-1 monocytes exposed to microbiologically (multiples of modal MIC against Staphylococcus aureus) and therapeutically (Cmin - Cmax) pertinent concentrations. Read More

    Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with hypothyroidism and psychiatric disorders.
    eNeurologicalSci 2017 Mar 4;6:16-20. Epub 2016 Nov 4.
    Department of Neurology, Tongji University Affiliated Tenth People's Hospital, 200072 Shanghai, PR China.
    Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a clinical syndrome associated with mitochondrial disorders (MIDs). This report illustrates a case of MELAS syndrome with hypothyroidism and psychiatric disorders, which is different from the common clinical manifestations of MELAS syndrome, such as exercise intolerance, migraine-like headaches, hearing loss and seizures etc. There are considerable interests in the possibility that mitochondrial dysfunction may play a role in the pathogenesis of endocrine dysfunctions and psychiatric disorders in MELAS syndrome. Read More

    Intravascular large B-cell lymphoma with multi-organ failure presenting as a pancreatic mass: a case with atypical presentation and definite diagnosis postmortem.
    Autops Case Rep 2017 Oct-Dec;7(4):30-36. Epub 2017 Dec 8.
    New York University Langone Medical Center, Department of Pathology, Division of Hematopathology. New York, NY, USA.
    Intravascular large B-cell lymphoma (IVLBCL) is a very rare extra nodal lymphoma that tends to proliferate within small blood vessels, particularly capillaries and postcapillary venules while sparing the organ parenchyma. The cause of its affinity for the vascular bed remains unknown. Because of its rarity and unremarkable clinical presentation, a timely diagnosis of IVLBCL is very challenging. Read More

    Phenformin has anti-tumorigenic effects in human ovarian cancer cells and in an orthotopic mouse model of serous ovarian cancer.
    Oncotarget 2017 Nov 24;8(59):100113-100127. Epub 2017 Oct 24.
    Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Obesity and diabetes have been associated with increased risk and worse outcomes in ovarian cancer (OC). The biguanide metformin is used in the treatment of type 2 diabetes and is also believed to have anti-tumorigenic benefits. Metformin is highly hydrophilic and requires organic cation transporters (OCTs) for entry into human cells. Read More

    Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report.
    BMC Neurol 2017 Dec 13;17(1):217. Epub 2017 Dec 13.
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
    Background: Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome, is the most common phenotype of mitochondrial disease. It often develops in childhood or adolescence, usually before the age of 40, in a maternally-inherited manner. Mutations in mitochondrial DNA (mtDNA) are frequently responsible for MELAS. Read More

    Complete mtDNA sequencing reveals mutations m.9185T>C and m.13513G>A in three patients with Leigh syndrome.
    Mitochondrial DNA A DNA Mapp Seq Anal 2017 Dec 12:1-6. Epub 2017 Dec 12.
    a Latvian Biomedical Research and Study Centre , Riga , Latvia.
    The most common mitochondrial disorder in children is Leigh syndrome, which is a progressive and genetically heterogeneous neurodegenerative disorder caused by mutations in nuclear genes or mitochondrial DNA (mtDNA). In the present study, a novel and robust method of complete mtDNA sequencing, which allows amplification of the whole mitochondrial genome, was tested. Complete mtDNA sequencing was performed in a cohort of patients with suspected mitochondrial mutations. Read More

    Hypoglycemia and severe lactic acidosis in a dog following metformin exposure.
    Clin Case Rep 2017 Dec 13;5(12):2097-2104. Epub 2017 Nov 13.
    Massachusetts Veterinary Referral HospitalWoburnMassachusetts01801USA.
    Hypoglycemia and lactic acidosis are rare complications with metformin use in humans. As metformin is not commonly used in veterinary medicine, severe adverse effects secondary to exposure are not known. Awareness of potentially life-threatening complications with metformin exposure is an important addition to the veterinary literature. Read More

    Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors.
    Eur J Clin Pharmacol 2017 Dec 8. Epub 2017 Dec 8.
    Department of General Internal Medicine, National Hospital Organization, Tokyo Medical Center, Tokyo, 152-8902, Japan.
    Purpose: Lactic acidosis is a rare complication of linezolid (LZD) therapy, and its incidence and risk factors remain unknown. This study aimed to compare the incidence of LZD-associated lactic acidosis (LALA) and vancomycin (VAN)-associated lactic acidosis (VALA) and investigate the risk factors for LALA.

    Methods: We performed a retrospective cohort study using propensity score-matched analyses comparing the incidence of lactic acidosis between LZD and VAN therapy. Read More

    D-lactic acidosis in humans: systematic literature review.
    Pediatr Nephrol 2017 Dec 7. Epub 2017 Dec 7.
    Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
    Background: D-lactic acidosis is an uncommon and challenging form of metabolic acidosis that may develop in short bowel syndrome. It has been documented exclusively in case reports and small case series.

    Methods: We performed a review of the literature in the National Library of Medicine and Excerpta Medica databases. Read More

    Clinical, Molecular, and Computational Analysis in two cases with mitochondrial encephalomyopathy associated with SUCLG1 mutation in a consanguineous family.
    Biochem Biophys Res Commun 2018 Jan 5;495(2):1730-1737. Epub 2017 Dec 5.
    Laboratory of Molecular and Functional Genetics, Faculty of Science of Sfax, University of Sfax, Tunisia. Electronic address:
    Deficiency of the mitochondrial enzyme succinyl COA ligase (SUCL) is associated with encephalomyopathic mtDNA depletion syndrome and methylmalonic aciduria. This disorder is caused by mutations in both SUCL subunits genes: SUCLG1 (α subnit) and SUCLA2 (β subnit). We report here, two Tunisian patients belonging to a consanguineous family with mitochondrial encephalomyopathy, hearing loss, lactic acidosis, hypotonia, psychomotor retardation and methylmalonic aciduria. Read More

    Does metformin exposure before ICU stay have any impact on patients' outcome? A retrospective cohort study of diabetic patients.
    Ann Intensive Care 2017 Dec 2;7(1):116. Epub 2017 Dec 2.
    Service de Réanimation Polyvalente, Hôpital de Bethune, 62408, Bethune, France.
    Background: Impact of metformin exposure before ICU stay remains controversial. Metformin is thought to induce lactic acidosis and haemodynamic instability but may reduce ICU mortality. We evaluated its influence on outcome in diabetic patients admitted in the ICU and then compared two different populations based on the presence of septic shock. Read More

    Kombucha: is a cup of tea good for you?
    BMJ Case Rep 2017 Dec 2;2017. Epub 2017 Dec 2.
    Department of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
    A 54-year-old asthmatic woman presented to hospital with a 10-day history of breathlessness. On examination, she was tachypnoeic with mild wheeze. She had preserved peak flows and was saturating at 100% on room air. Read More

    Focal Segmental Glomerulosclerosis Associated with Chronic Progressive External Ophthalmoplegia and Mitochondrial DNA A3243G Mutation.
    Nephron 2017 Nov 30. Epub 2017 Nov 30.
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Focal segmental glomerulosclerosis (FSGS) is caused by various etiologies, with mitochondrial dysfunction being one of the causes. FSGS is known to be associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), which is a subclass of mitochondrial disease. However, it has rarely been reported in other mitochondrial disease subclasses. Read More

    [Metformin-associated lactic acidosis. Report of one case].
    Rev Med Chil 2017 Aug;145(8):1072-1075
    Centro de Pacientes Críticos, Clínica Las Condes, Santiago, Chile.
    Metformin-associated lactic acidosis is a severe and infrequent adverse event. Early diagnosis is essential to start an early treatment, which often has favorable results. We report a 56 years old non-insulin-requiring type 2 diabetic female who developed a severe metabolic acidosis associated with metformin in relation to an acute renal failure secondary to infectious diarrhea. Read More

    Wet Beriberi Associated with Hikikomori Syndrome.
    J Gen Intern Med 2017 Nov 29. Epub 2017 Nov 29.
    Department of Critical Care Medicine, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu-city, Japan.
    Wet beriberi, characterized by high cardiac output with predominantly right-sided heart failure and lactic acidosis, is a disease caused by thiamine deficiency, and is rarely seen in modern society. However, patients with social withdrawal syndrome, also known as hikikomori syndrome, may be a new population at risk of thiamine deficiency. Hikikomori syndrome, first recognized in Japan, is becoming a worldwide issue. Read More

    Cardiopulmonary rehabilitation program impact on prognostic markers in selected patients with resting and exercise-induced ventilatory inefficiency: a clinical trial.
    J Phys Ther Sci 2017 Oct 21;29(10):1803-1810. Epub 2017 Oct 21.
    Physical Therapy Department for Cardiovascular/Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University, Egypt.
    [Purpose] Ventilatory limitation is a common problem in patients with chronic heart failure and pulmonary hypertension. Excess ventilation may arise from augmented ventilatory drive, over activity of chemoreceptors and muscle ergoreceptors, or premature onset of lactic acidosis. Exertional dyspnea can cause limitations in the activities of daily living and as a result, reduced quality of life for these patients. Read More

    Rhabdomyolysis, lactic acidosis, and multiple organ failure during telbivudine treatment for hepatitis B: a case report and review of the literature.
    J Med Case Rep 2017 Nov 27;11(1):331. Epub 2017 Nov 27.
    Department of Infectious Diseases and Shenzhen Key Lab for Endogenous Infection, Shenzhen Nanshan Hospital, Shenzhen University, No 89, Taoyuan Road, Nanshan District, Shenzhen, 518052, China.
    Background: Telbivudine can cause severe side effects, including myositis, neuritis, rhabdomyolysis, and lactic acidosis. However, reported cases of telbivudine leading to multiple organ failure are rare. Here, we report a case of telbivudine-induced severe polymyositis, lactic acidosis, and multiple organ failure. Read More

    Stercoral colitis complicated with ischemic colitis: a double-edge sword.
    BMC Gastroenterol 2017 Nov 28;17(1):129. Epub 2017 Nov 28.
    Department of Internal Medicine, Wayne State University-School of Medicine, 1101 W University Dr. 2-South, Rochester, MI, 48307, USA.
    Background: Stercoral colitis is a rare inflammatory process involving the colonic wall secondary to fecal impaction with high morbidity and mortality; especially if complicated with ischemic colitis, stercoral ulcer formation and subsequent perforation. There are several case reports published on abdominal perforation resulting from stercoral colitis. However, stercoral colitis complicated by ischemic colitis is rare. Read More

    Retrospective evaluation of the prognostic utility of plasma lactate concentration, base deficit, pH, and anion gap in canine and feline emergency patients.
    J Vet Emerg Crit Care (San Antonio) 2018 Jan 22;28(1):54-61. Epub 2017 Nov 22.
    Departments of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616.
    Objective: To determine the association of plasma lactate concentration, pH, base deficit (BD), and anion gap (AG) in dogs and cats on presentation to an emergency room with outcome, and to compare the prognostic significance of hyperlactatemia with a concurrent metabolic acidosis with that of hyperlactatemia and a normal metabolic acid-base balance.

    Design: Retrospective study.

    Setting: University teaching hospital. Read More

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