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    1 OF 161

    Incidence and Consequences of Near-Drowning-Related Pneumonia-A Descriptive Series from Martinique, French West Indies.
    Int J Environ Res Public Health 2017 Nov 17;14(11). Epub 2017 Nov 17.
    Intensive Care Unit, University Hospital of Martinique, Fort-de-France, 97261 Martinique, France.
    Drowning represents one major cause of accidental death. Near-drowning patients are exposed to aspiration that may result in pneumonia with life-threatening consequences. We designed this descriptive study to investigate the frequency, nature, and consequences of post-drowning pneumonia. Read More

    Single-centre experience with the Impella CP, 5.0 and RP in 109 consecutive patients with profound cardiogenic shock.
    Eur Heart J Acute Cardiovasc Care 2017 Nov 1:2048872617743194. Epub 2017 Nov 1.
    1 Department of Cardiology, Cardio-Thoracic surgery and Anesthesiology, Odense University Hospital, Denmark.
    Rationale: Short-term mechanical circulatory support is increasingly used in the management of cardiogenic shock, but data from controlled studies are sparse. Thus, real-life data on complication rates and predictors of adverse outcome are important.

    Objective: The objective of this study was to analyse the experience with Impella devices in the management of profound cardiogenic shock. Read More

    TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.
    Sci Rep 2017 Nov 14;7(1):15557. Epub 2017 Nov 14.
    Department of Anatomy I, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
    Induced pluripotent stem cells (iPSCs) are suitable for studying mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations. Here, we generated iPSCs from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with the m.13513G>A mutation. Read More

    Intensive care in severe malaria: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine.
    J Crit Care 2017 Nov 8. Epub 2017 Nov 8.
    Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India. Electronic address:
    Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P vivax is increasingly found to cause severe malaria in Asia. Read More

    [Metformin-associated lactic acidosis: an insufficiently recognised problem].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1823
    Rijnstate Arnhem, Arnhem.
    Metformin-associated lactic acidosis (MALA) is a rare but potentially fatal condition that can easily be avoided. As metformin is known to facilitate the production of lactate, predisposing factors can accelerate this process. In situations of infection or dehydration, metformin can accumulate due to kidney failure, hereby increasing the risk of MALA. Read More

    Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient.
    Case Rep Crit Care 2017 8;2017:5121032. Epub 2017 Oct 8.
    Section of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
    Thiamine plays a critical role in energy metabolism. Critically ill children and adults may develop thiamine deficiency with ultimately increased mortality due to potentially irreversible consequences of severe type B lactic acidosis. We report a case of an unvaccinated term neonate with malignant pertussis requiring extracorporeal membrane oxygenation and continuous renal replacement therapy, who developed profound lactic acidosis of unknown etiology. Read More

    Safety of Metformin Therapy in Patients with Type 2 Diabetes Living on an Oxygen-Deficient Plateau, Tibet, China.
    Exp Clin Endocrinol Diabetes 2017 Nov 8. Epub 2017 Nov 8.
    Department of Endocrinology and Metabolism, People's Hospital of Tibet Autonomous Region, Tibet, P. R. China.
    Background In the general population, the absolute risk of lactic acidosis in patients treated with metformin appears to be low. However, in the Tibetan plateau, an extreme oxygen-deficient environment, there are no data available concerning the safety of metformin. The aim of our study is to assess the safety of metformin in people of the plateau area. Read More

    Impact of continuation of metformin prior to elective coronary angiography on acute contrast nephropathy in patients with normal or mildly impaired renal functions.
    Anatol J Cardiol 2017 10 31. Epub 2017 Oct 31.
    Department of Cardiology, Institute of Cardiology, İstanbul University; İstanbul-Turkey.
    Objective: Discontinuation of metformin treatment in patients scheduled for elective coronary angiography (CAG) is controversial because of post-procedural risks including acute contrast-induced nephropathy (CIN) and lactic acidosis (LA). This study aims to discuss the safety of continuing metformin treatment in patients undergoing elective CAG with normal or mildly impaired renal functions.

    Methods: Our study was designed as a single-centered, randomized, and observational study including 268 patients undergoing elective CAG with an estimated glomerular filtration rate of >60 mL/min/1. Read More

    Fluorometric determination of d-lactate in biological fluids.
    Anal Biochem 2017 Nov 3;539:152-157. Epub 2017 Nov 3.
    Dept. of Animal Science, Aarhus University, Blichers Allé 20, Postboks 50, DK-8830, Tjele, Denmark. Electronic address:
    Objective: D-lactic acid in the mammalian body is mainly of microbiological origin and is often located somewhere along the digestive tract. Surgical, extensive re-sectioning of the small bowel may be one of the risk factors for altered balance in the microbiological environment. Higher levels in the body may lead to D-lactate acidosis and neurotoxicity; consequently, the possibility of diagnosis of this condition is important. Read More

    Metformin intoxication: Vasopressin's key role in the management of severe lactic acidosis.
    Am J Emerg Med 2017 Oct 28. Epub 2017 Oct 28.
    Anesthesia, Intensive Care, Reanimation and Pain Medicine School of Medicine, University of Pisa, Pisa, Italy. Electronic address:
    Vasopressin is a potent vasopressor used for improving organ perfusion during cardiac arrest, septic and catecholamine-resistant shock; with reference to this, it is useful for the treatment of vasoplegic shock because, restoring organ perfusion pressure by contraction of vascular smooth muscle through a non-catecholamine receptor pathway, it can be employed when catecholamines are ineffective. A 49-yr-old woman was admitted to the Emergency Department after having intentionally taken 95.2g of metformin, 1. Read More

    Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease.
    Oncotarget 2017 Sep 1;8(43):73627-73639. Epub 2017 Sep 1.
    Department of Neurosurgery, Mackay Memorial Hospital, Taipei, Taiwan.
    Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is most commonly caused by the A3243G mutation of mitochondrial DNA. The capacity to utilize fatty acid or glucose as a fuel source and how such dynamic switches of metabolic fuel preferences and transcriptional modulation of adaptive mechanism in response to energy deficiency in MELAS syndrome have not been fully elucidated. The fibroblasts from patients with MELAS syndrome demonstrated a remarkable deficiency of electron transport chain complexes I and IV, an impaired cellular biogenesis under glucose deprivation, and a decreased ATP synthesis. Read More

    Quantitative relationships among plasma lactate, inorganic phosphorus, albumin, unmeasured anions and the anion gap in lactic acidosis.
    J Crit Care 2017 Oct 13;44:101-110. Epub 2017 Oct 13.
    Department of Anesthesiology, Kobe University Hospital, Kobe City, Hyogo 650-0017, Japan.
    Background: Quantitative relationships among plasma [Lactate], [Pi], [Albumin], unmeasured anions ([UA]) and the anion gap (AGK) in lactic acidosis (LA) are not well defined.

    Methods: A mathematical model featuring compensatory potassium and chloride shifts and respiratory changes in LA demonstrated: (1) AGK=[Lactate]+Zp×[Pi]+2.4×[Albumin]+constant1+e, where Zp is a function of pH, and e reflects unmeasured anions and cations plus pH-related variations. Read More

    A novel de novo dominant mutation in ISCU associated with mitochondrial myopathy.
    J Med Genet 2017 Oct 27. Epub 2017 Oct 27.
    Molecular Neurogenetics Unit, Foundation IRCCS Neurological Institute Besta, Milan, Italy.
    Background: Hereditary myopathy with lactic acidosis and myopathy with deficiency of succinate dehydrogenase and aconitase are variants of a recessive disorder characterised by childhood-onset early fatigue, dyspnoea and palpitations on trivial exercise. The disease is non-progressive, but life-threatening episodes of widespread weakness, metabolic acidosis and rhabdomyolysis may occur. So far, this disease has been molecularly defined only in Swedish patients, all homozygous for a deep intronic splicing affecting mutation in ISCU encoding a scaffold protein for the assembly of iron-sulfur (Fe-S) clusters. Read More

    Metformin for endometrial hyperplasia.
    Cochrane Database Syst Rev 2017 Oct 27;10:CD012214. Epub 2017 Oct 27.
    Faculty of Health Sciences and Medicine, University of Nottingham, Queen's Medical Centre, Derby Road, Nottingham, UK, NG7 2UH.
    Background: Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead to endometrial cancer if left untreated. Read More

    Systemic Inflammatory Response and Multiple Organ Dysfunctions Following Crush Injury: a New Experimental Model in Rabbits.
    Inflammation 2017 Oct 25. Epub 2017 Oct 25.
    Wuhan Medical Emergency Center, 10 Xinhua Road, Wuhan, Hubei, 430000, China.
    In this study, we aim to develop a new, reproducible crush injury (CI) model in rabbits. Anesthetized rabbits were compressed on both hind limbs using a special instrument for 6 h followed by 3 h of reperfusion. Blood samples and injured muscles were collected for biochemical analysis and morphological evaluation. Read More

    Ethylene Glycol Teratogenicity: A Role for Embryonic Acidosis?
    Toxicol Sci 2017 Oct 23. Epub 2017 Oct 23.
    Department of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia.
    Ethylene glycol (EG) is a developmental toxicant in pregnant rats and mice. A suggested mechanism for this toxicity is that the EG metabolite, glycolic acid (GA), causes acidosis which may affect the embryonic heart rate. This inhibition would cause periods of embryonic bradycardia and arrhythmia resulting in increased embryonic death and malformation in surviving embryos. Read More

    An Investigation into Rumen Fungal and Protozoal Diversity in Three Rumen Fractions, during High-Fiber or Grain-Induced Sub-Acute Ruminal Acidosis Conditions, with or without Active Dry Yeast Supplementation.
    Front Microbiol 2017 10;8:1943. Epub 2017 Oct 10.
    Animal Biosciences, University of Guelph, Guelph, ON, Canada.
    Sub-acute ruminal acidosis (SARA) is a gastrointestinal functional disorder in livestock characterized by low rumen pH, which reduces rumen function, microbial diversity, host performance, and host immune function. Dietary management is used to prevent SARA, often with yeast supplementation as a pH buffer. Almost nothing is known about the effect of SARA or yeast supplementation on ruminal protozoal and fungal diversity, despite their roles in fiber degradation. Read More

    Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery.
    Obes Surg 2017 Oct 23. Epub 2017 Oct 23.
    Departments of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
    Background: Pharmacokinetic data suggest that the risk of metformin-associated lactic acidosis (MALA) may be increased after Roux-en-Y gastric bypass (RYGB) surgery. The aim of this study was to examine the impact of metformin on plasma lactate levels before and after RYGB surgery.

    Methods: Retrospective study of plasma lactate levels before and 3 months after RYGB surgery in patients with type 2 diabetes mellitus (T2DM) not using metformin (MET-0, N = 58), on a stable dose (MET-S, N = 138), or on a decreasing dose (MET-D, N = 85) of metformin. Read More

    Focal segmental glomerulosclerosis associated with mitochondrial disease.
    Clin Nephrol Case Stud 2017 3;5:20-25. Epub 2017 Mar 3.
    Department of Genetics and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Primary mitochondrial diseases (MD) are complex, heterogeneous inherited diseases caused by mutations in either the mitochondrial or nuclear DNA. Glomerular diseases in MD have been reported with tRNA mutation m.3243A>G causing a syndrome of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). Read More

    Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills.
    Sci Rep 2017 Oct 16;7(1):12796. Epub 2017 Oct 16.
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, 95616, USA.
    Protein S-palmitoylation is a reversible post-translational modification mediated by palmitoyl acyltransferase enzymes, a group of Zn(2+)-finger DHHC-domain-containing proteins (ZDHHC). Here, for the first time, we show that Zdhhc13 plays a key role in anxiety-related behaviors and motor function, as well as brain bioenergetics, in a mouse model (luc) carrying a spontaneous Zdhhc13 recessive mutation. At 3 m of age, mutant mice displayed increased sensorimotor gating, anxiety, hypoactivity, and decreased motor coordination, compared to littermate controls. Read More

    Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes-MELAS Syndrome.
    Ochsner J 2017 ;17(3):296-301
    Department of Radiology, Louisiana State University Health Sciences Center, New Orleans, LA.
    Background: Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome is a rare inherited disorder that results in waxing and waning nervous system and muscle dysfunction. MELAS syndrome may overlap with other neurologic disorders but shows distinctive imaging features.

    Case Report: We present the case of a 28-year-old female with atypical stroke-like symptoms, a strong family history of stroke-like symptoms, and a relapsing-remitting course for several years. Read More

    Incidence of diabetes mellitus and neoplasia in Japanese short-statured children treated with growth hormone in the Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS).
    Clin Pediatr Endocrinol 2017 28;26(4):229-241. Epub 2017 Sep 28.
    JCHO Osaka Hospital, Osaka, Japan.
    The primary goal of the Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) was to assess the safety and effectiveness of Humatrope(®), a GH preparation, in the treatment of pediatric patients with short stature. We report our findings in the GH-treated Japanese pediatric population focusing on the incidence of type 2 diabetes (T2D) and occurrence of neoplasms. A total of 2,345 Japanese patients were assessed for safety. Read More

    Pathology of mitochondria in MELAS syndrome: an ultrastructural study.
    Pol J Pathol 2017;68(2):173-181
    Ultrastructural changes in skeletal muscle biopsy in a 24-year-old female patient with clinically suspected mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS) syndrome are presented. We observed proliferation and/or pleomorphism of mitochondria in skeletal muscle and smooth muscle cells of arterioles, as well as in pericytes of capillaries. Paracrystalline inclusions were found only in damaged mitochondria of skeletal muscle. Read More

    Dietary Therapy for Von Gierke's Disease: A Case Report.
    Cureus 2017 Aug 8;9(8):e1548. Epub 2017 Aug 8.
    Department of Oncology, Jinnah Post Graduate Medical Centre, Karachi, Pakistan.
    Von Gierke's disease, also known as glycogen storage disease (GSD) type 1A, is an autosomal recessive disease in which there is an inability to cleave glycogen to glucose because of a glucose 6 phosphate deficiency resulting in hypoglycemia and lactic acidosis. The patient may present with hepatomegaly and signs and symptoms of hypoglycemia. We diagnosed a case of Von Gierke's disease in a seven-month-old female infant who was admitted for abdominal distension, vomiting, and lethargy for a duration of four months with characteristic rounded doll's face, fatty cheeks, protuberant abdomen, and massive hepatomegaly. Read More

    Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families.
    J Pediatr Endocrinol Metab 2017 Oct;30(11):1203-1210
    .
    Background: Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare inherited metabolic disorder characterized by recurrent episodes of hypoglycemia, ketosis and lactic acidosis. FBPase is encoded by FBP1 gene and catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate in the last step of gluconeogenesis. We report here FBP1 mutations in nine consanguineous Pakistani families affected with FBPase deficiency. Read More

    Relationship of at Admission Lactate, Unmeasured Anions, and Chloride to the Outcome of Critically Ill Patients.
    Crit Care Med 2017 Dec;45(12):e1233-e1239
    1Servicio de Terapia Intensiva, Sanatorio de la Trinidad Ramos Mejía, Ramos Mejía, Argentina.2Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina.
    Objectives: To investigate the association between the concentration of the causative anions responsible for the main types of metabolic acidosis and the outcome.

    Design: Prospective observational study.

    Setting: Teaching ICU. Read More

    Patients with glycogen storage diseases undergoing anesthesia: a case series.
    BMC Anesthesiol 2017 Oct 6;17(1):134. Epub 2017 Oct 6.
    Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
    Background: Glycogen storage diseases are rare genetic disorders of glycogen synthesis, degradation, or metabolism regulation. When these patients are subjected to anesthesia, perioperative complications can develop, including hypoglycemia, rhabdomyolysis, myoglobinuria, acute renal failure, and postoperative fatigue. The objective of this study was to describe the perioperative course of a cohort of patients with glycogen storage diseases. Read More

    Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome.
    Hum Mol Genet 2017 Nov;26(21):4257-4266
    Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK.
    Defects in nuclear-encoded proteins of the mitochondrial translation machinery cause early-onset and tissue-specific deficiency of one or more OXPHOS complexes. Here, we report a 7-year-old Italian boy with childhood-onset rapidly progressive encephalomyopathy and stroke-like episodes. Multiple OXPHOS defects and decreased mtDNA copy number (40%) were detected in muscle homogenate. Read More

    Acute mitochondrial myopathy with respiratory insufficiency and motor axonal polyneuropathy.
    Int J Neurosci 2017 Oct 16:1-6. Epub 2017 Oct 16.
    d Department of Neurology , Tongren Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
    Background: Mitochondrial myopathies (MMs) are mainly presented with chronic muscle weakness and accompanied with other syndromes. MM with acute respiratory insufficiency is rare.

    Aims: To reveal the clinical, pathological and molecular characteristics of a life-threatening MM. Read More

    Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A > G mitochondrial DNA mutation.
    Sci Rep 2017 Sep 26;7(1):12320. Epub 2017 Sep 26.
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, United Kingdom.
    The m.3243A > G mitochondrial DNA mutation was originally described in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes. The phenotypic spectrum of the m. Read More

    Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies.
    Am J Hum Genet 2017 Oct 21;101(4):525-538. Epub 2017 Sep 21.
    Institute of Human Genetics, Technische Universität München, 81675 Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany. Electronic address:
    Complement component 1 Q subcomponent-binding protein (C1QBP; also known as p32) is a multi-compartmental protein whose precise function remains unknown. It is an evolutionary conserved multifunctional protein localized primarily in the mitochondrial matrix and has roles in inflammation and infection processes, mitochondrial ribosome biogenesis, and regulation of apoptosis and nuclear transcription. It has an N-terminal mitochondrial targeting peptide that is proteolytically processed after import into the mitochondrial matrix, where it forms a homotrimeric complex organized in a doughnut-shaped structure. Read More

    Peri-operative continuation of metformin does not improve glycaemic control in patients with type 2 diabetes: A randomized controlled trial.
    Diabetes Obes Metab 2017 Sep 20. Epub 2017 Sep 20.
    Department of Anaesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
    Historically, metformin was withheld before surgery for fear of metformin-associated lactic acidosis. Currently, however, this risk is deemed to be low and guidelines have moved towards the continuation of metformin. We hypothesized that continuing metformin peri-operatively would lower postoperative serum glucose level without an effect on plasma lactate levels. Read More

    Common, yet elusive: a case of severe anion gap acidosis.
    Oxf Med Case Reports 2017 Sep 4;2017(9):omx054. Epub 2017 Sep 4.
    Department of Internal Medicine, Albert Einstein Medical Center, 5501 Old York Road, Suite 363, Philadelphia, PA, USA.
    Acid-base disturbances are common occurrence in hospitalized patients with life threatening complications. 5-oxoproline has been increasingly recognized as cause of high anion gap metabolic acidosis (AGMA) in association with chronic acetaminophen use. However, laboratory workup for it are not widely available. Read More

    Non-Mammalian Vertebrates: Distinct Models to Assess the Role of Ion Gradients in Energy Expenditure.
    Front Endocrinol (Lausanne) 2017 1;8:224. Epub 2017 Sep 1.
    School of Animal and Comparative Biomedical Science, University of Arizona, Tucson, AZ, United States.
    Animals store metabolic energy as electrochemical gradients. At least 50% of mammalian energy is expended to maintain electrochemical gradients across the inner mitochondrial membrane (H(+)), the sarcoplasmic reticulum (Ca(++)), and the plasma membrane (Na(+)/K(+)). The potential energy of these gradients can be used to perform work (e. Read More

    Enzymatic testing sensitivity, variability and practical diagnostic algorithm for pyruvate dehydrogenase complex (PDC) deficiency.
    Mol Genet Metab 2017 Sep 8. Epub 2017 Sep 8.
    Center for Inherited Disorders of Energy Metabolism (CIDEM), University Hospitals Cleveland Medical Center (UHCMC), Cleveland, OH, USA; Department of Genetics and Genome Sciences, CWRU, Cleveland, OH, USA; Center for Human Genetics, UHCMC, Cleveland, OH, USA. Electronic address:
    Pyruvate dehydrogenase complex (PDC) deficiency is a major cause of primary lactic acidemia in children. Prompt and correct diagnosis of PDC deficiency and differentiating between specific vs generalized, or secondary deficiencies has important implications for clinical management and therapeutic interventions. Both genetic and enzymatic testing approaches are being used in the diagnosis of PDC deficiency. Read More

    Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.
    J Clin Pharmacol 2017 Sep 15. Epub 2017 Sep 15.
    Center for Pharmacometrics & Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, USA.
    Dichloroacetate (DCA) is an investigational drug used to treat congenital lactic acidosis and other mitochondrial disorders. Response to DCA therapy in young children may be suboptimal following body weight-based dosing. This is because of autoinhibition of its metabolism, age-dependent changes in pharmacokinetics, and polymorphisms in glutathione transferase zeta 1 (GSTZ1), its primary metabolizing enzyme. Read More

    Risk factor analysis for nonocclusive mesenteric ischemia following cardiac surgery: A case-control study.
    Medicine (Baltimore) 2017 Sep;96(37):e8029
    Departments of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    Although rare, postcardiac surgery nonocclusive mesenteric ischemia (NOMI) is a life-threatening condition. Identifying the risk factors for NOMI during immediate postoperative period may help early detection and intervention, which leads to improved clinical outcomes. The objective of this study was to identify the clinical features and risk factors of NOMI for prognosis identification after cardiac surgery, focusing on immediate postoperative parameters. Read More

    Biallelic variants in WARS2 encoding mitochondrial tryptophanyl-tRNA synthase in six individuals with mitochondrial encephalopathy.
    Hum Mutat 2017 Dec 6;38(12):1786-1795. Epub 2017 Oct 6.
    Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
    Mitochondrial protein synthesis involves an intricate interplay between mitochondrial DNA encoded RNAs and nuclear DNA encoded proteins, such as ribosomal proteins and aminoacyl-tRNA synthases. Eukaryotic cells contain 17 mitochondria-specific aminoacyl-tRNA synthases. WARS2 encodes mitochondrial tryptophanyl-tRNA synthase (mtTrpRS), a homodimeric class Ic enzyme (mitochondrial tryptophan-tRNA ligase; EC 6. Read More

    Hemodialysis for Lactic Acidosis.
    Indian J Crit Care Med 2017 Aug;21(8):537-538
    Department of Critical Care Medicine, Apollo First Med Hospital, Chennai, Tamil Nadu, India.
    Lactic acidosis (Type A) is common in critically ill patients and usually treated by correcting the underlying etiology. We present the case of a young female who presented with life-threatening lactic acidosis secondary to hematological malignancy. Timely initiation of hemodialysis was lifesaving. Read More

    The pathophysiological basis of the protective effects of metformin in heart failure.
    Postepy Hig Med Dosw (Online) 2017 Aug;71(1):773-787
    Katedra i Zakład Patofizjologii, Uniwersytet Medyczny w Lublinie.
    Metformin, currently recommended as the drug of first choice in type 2 diabetes mellitus (T2DM), is one of the few antihiperglycemic drugs to reduce cardiovascular risk. Nonetheless, due to the risk of lactic acidosis during metformin therapy, its usage in patients with diabetes and heart failure (HF) is still a matter of debate. The aim of this review is to present data supporting the possibility of using metformin in the treatment of diabetic patients with concomitant heart failure. Read More

    MELAS syndrome associated with a new mitochondrial tRNA-Val gene mutation (m.1616A>G).
    BMJ Case Rep 2017 Sep 11;2017. Epub 2017 Sep 11.
    Department of Neurology, Gifu Municipal Hospital, Gifu City, Japan.
    We describe the case of a 40-year-old-man with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome, with cardiomyopathy and severe heart failure. He had a mitochondrial transfer RNA (tRNA) mutation (m.1616A>G) of the (tRNA-Val) gene, and it was not found in MELAS syndrome ever before. Read More

    Role of cathepsin K in the development of chronic subdural hematoma.
    J Clin Neurosci 2017 Nov 6;45:343-347. Epub 2017 Sep 6.
    Department of Neurological Surgery, Juntendo University School of Medicine, Japan.
    Despite extensive investigations, the process of development of chronic subdural hematoma (CSDH) is not known. The present study aims to investigate CSDH by measuring biomarkers in it, gas analysis, and immunohistochemical examination. A total of 42 patients with symptomatic CSDH who underwent burr-hole drainage were enrolled. Read More

    Out-of-hospital cardiac arrest: always coronary angiography?
    Expert Rev Cardiovasc Ther 2017 Nov 18;15(11):847-851. Epub 2017 Sep 18.
    c Division of Cardiology , A.S.L. VCO , Omegna , Italy.
    Introduction: Out-of-hospital cardiac arrest (OHCA) remains one of the principle challenges in the setting of critical care medicine and emergency cardiology. Areas covered: Long-term survival rates even after successful resuscitation are variable but increasing in the recent years; due to the improvement of base and advanced cardiac life support techniques an increasing number of resuscitated patients are admitted to the hospital. Recent data suggested that patients surviving to hospital discharge after OHCA presented long-term outcome similar to patients with ST-elevation myocardial infarction. Read More

    Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation.
    Sci Rep 2017 Sep 6;7(1):10710. Epub 2017 Sep 6.
    Vascular and Genomic Center, Changhua Christian Hospital, Changhua, Taiwan.
    The cell penetrating peptide, Pep-1, has been shown to facilitate cellular uptake of foreign mitochondria but further research is required to evaluate the use of Pep-1-mediated mitochondrial delivery (PMD) in treating mitochondrial defects. Presently, we sought to determine whether mitochondrial transplantation rescue mitochondrial function in a cybrid cell model of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) disease. Following PMD, recipient cells had internalized donor mitochondria after 1 h, and expressed higher levels of normal mitochondrial DNA, particularly at the end of the treatment and 11 days later. Read More

    Parameters for Ordering Blood Cultures in Major Burn Injury Patients: Improving Clinical Assessment.
    J Burn Care Res 2017 Aug 31. Epub 2017 Aug 31.
    From the *Department of Plastic Surgery, University of Kansas Medical Center, Kansas City, KS; †Department of Surgery, University of Illinois College of Medicine at Urbana-Champaign, Urbana, IL; ‡University of Kansas School of Medicine, Kansas City, KS; §Department of Preventative Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS.
    Hypermetabolic and catabolic states in large TBSA burns lead to higher basal body temperature and tachycardia. These metabolic changes complicate the diagnosis of bacteremia and sepsis. Current indications for obtaining blood cultures (BCs) in this population are poorly described and nonstandardized. Read More

    [Clinical effect of terminal branches portal vein embolization combined with transcatheter arterial chemoembolization on liver neoplasms].
    Zhonghua Wai Ke Za Zhi 2017 Sep;55(9):655-660
    Department of Surgery, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
    Objective: To analyze the efficacy of branches portal vein embolization (TBPVE) combined with transcatheter arterial chemoembolization (TACE) on liver neoplasms. Methods: From August 2016 to May 2017, there were 13 patients including 11 males and 2 females with primary hepatocellular carcinoma who underwent TBPVE+ TACE , among whom there were 11 cases with a history of HBV infection.Average age of the 13 patients was (60. Read More

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