8,247 results match your criteria Lactic Acidosis


The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs.

Biochim Biophys Acta 2018 Jun 18. Epub 2018 Jun 18.

RNA Modification and Mitochondrial Diseases Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Carrer d'Eduardo Primo Yúfera 3, Valencia 46012, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) node 721, Madrid 28029, Spain. Electronic address:

The pathomechanisms underlying oxidative phosphorylation (OXPHOS) diseases are not well-understood, but they involve maladaptive changes in mitochondria-nucleus communication. Many studies on the mitochondria-nucleus cross-talk triggered by mitochondrial dysfunction have focused on the role played by regulatory proteins, while the participation of miRNAs remains poorly explored. MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is mostly caused by mutation m. Read More

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Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma.

Biochem Biophys Res Commun 2018 Jun 18. Epub 2018 Jun 18.

Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, China.

The Warburg effect is a dominant phenotype of most tumor cells. Recent reports have shown that the Warburg effect can be reprogrammed by the tumor microenvironment. Lactic acidosis and glucose deprivation are the common adverse microenvironments in solid tumor. Read More

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The Hypothesis of Circulus Hypoxicus and Its Clinical Relevance in Patients with Methanol Poisoning - an Observational Study of 35 Patients.

Basic Clin Pharmacol Toxicol 2018 Jun 20. Epub 2018 Jun 20.

Department of Acute Medicine, Division of Medicine, Oslo University Hospital, Ulleval.

Methanol mass poisoning is a global problem with high fatality rates and often severe sequelae in survivors. Patients typically present late to the hospital with severe metabolic acidosis followed by a rapid deterioration in their clinical status. The hypothesis "Circulus hypoxicus" describes the metabolic acidosis following methanol poisoning as a self-enhancing hypoxic circle responsible for methanol toxicity. Read More

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June 2018
2 Reads

A Homozygous Splice Site Mutation in SLC25A42, Encoding the Mitochondrial Transporter of Coenzyme A, Causes Metabolic Crises and Epileptic Encephalopathy.

JIMD Rep 2018 Jun 20. Epub 2018 Jun 20.

Institute of Human Genetics, Technische Universität München, Munich, Germany.

SLC25A42 is an inner mitochondrial membrane protein which has been shown to transport coenzyme A through a lipid bilayer in vitro. A homozygous missense variant in this gene has been recently reported in 13 subjects of Arab descent presenting with mitochondriopathy with variable clinical manifestations. By exome sequencing, we identified two additional individuals carrying rare variants in this gene. Read More

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June 2018
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Comparison of magnetic resonance spectroscopy (MRS) with arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic Acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS).

J Clin Neurosci 2018 Jun 16. Epub 2018 Jun 16.

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

To compare the utility and limitation of magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS), a retrospective review of 17 MELAS and 26 AIS patients were performed. In all patients both MRS and ASL scans were performed within 1 week after admission. Demographic, clinical, laboratory and MR imaging data were reviewed and compared between the two groups. Read More

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Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis.

Clin Transl Gastroenterol 2018 Jun 19;9(6):162. Epub 2018 Jun 19.

Division of Gastroenterology/Hepatology, Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Background: D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome. Whether it occurs in patients with an intact gut and unexplained gas and bloating is unknown. We aimed to determine if BF, gas and bloating is associated with D-lactic acidosis and small intestinal bacterial overgrowth (SIBO). Read More

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Beware of beta! A case of salbutamol-induced lactic acidosis in severe asthma.

BMJ Case Rep 2018 Jun 17;2018. Epub 2018 Jun 17.

Our Lady's Hospital Navan, Navan, Ireland.

A 22-year-old woman presented with symptoms and signs consistent with acute severe asthma. After significant doses of beta-agonist, she developed a significant lactic acidosis. Significant issues arose in this patient's history with regards to purchase of medications, compliance and follow-up with respiratory service. Read More

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June 2018
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Ocular findings in MELAS syndrome – a case report.

Klin Oczna 2016;118(4):301-7

We present a case of a child with MELAS syndrome (mitochondrial encephalo-myopathy with lactic acidosis and stroke-like episodes), discussing clinical manifestation, ocular findings and diagnostic challenges. Predominant ocular symptom was a transient complete visual loss, while the predominant ocular sign was a visual field defect. The diagnosia was based on clinical manifestation, laboratory tests, brain scans and genetic testing which confirmed the pathognomonic mutation in the MTTL1 gene encoding the mitochondrial tRNA for leucine 3243> G. Read More

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January 2016

Neurological impairments in hypoxic neonates and lactate levels.

Neurol Res 2018 Jun 18:1-6. Epub 2018 Jun 18.

a Department of Neonatology , Clinic for Gynecology and Obstetrics Clinical Center of Serbia , Belgrade , Serbia.

Introduction: Metabolic acidosis with increasing lactate concentration develops due to the lack of oxygen in the tissues.

Objectives: The effect of lactic acidosis on neurological development in the first year of life.

Materials And Methods: Our study included 50 newborns with perinatal hypoxia requiring oxygen therapy and 50 healthy newborns. Read More

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A Case of Linezolid Induced Toxicity.

J Pharm Pract 2018 Jan 1:897190018782787. Epub 2018 Jan 1.

1 Department of Pharmacy, Rush University Medical Center, Chicago, IL, USA.

Adverse effects of linezolid are typically limited to diarrhea, nausea, and headache when shorter durations are used; however, as extended durations of linezolid therapy are increasingly more common, additional monitoring parameters should be considered in these patients. We describe a unique case of hypoglycemia, lactic acidosis, and pancreatitis related to an extended duration of linezolid therapy. A 52-year-old woman presented with altered mental status, abdominal pain, and hypotension following six weeks of linezolid and ertapenem therapy. Read More

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January 2018
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Intestinal microbial and metabolic alterations following successful fecal microbiota transplant for D-lactic acidosis.

J Pediatr Gastroenterol Nutr 2018 Jun 12. Epub 2018 Jun 12.

Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Fecal microbiota transplantation (FMT) involves the transfer of stool from a healthy individual into the intestinal tract of a diseased recipient. Although used primarily for recurrent Clostridium difficile infection, FMT is increasingly being attempted as an experimental therapy for other illnesses, including metabolic disorders. D-lactic acidosis (D-LA) is a metabolic disorder that may occur in individuals with short bowel syndrome when lactate-producing bacteria in the colon overproduce D-lactate. Read More

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June 2018
3 Reads

Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolaviron Correlates with Reduction in Neurobehavioural Deficits.

Ann Neurosci 2018 Apr 23;25(1):53-62. Epub 2017 Nov 23.

Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, The Federal University of Technology, Akure, Nigeria.

Background: Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury.

Purpose: This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury.

Methods: KV was administered at a dose of 100 or 200 mg/kg to male Wistar rats 1 h before a 30 min BCCAO/4 h reperfusion (I/R). Read More

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Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study.

JAMA Intern Med 2018 Jun 4. Epub 2018 Jun 4.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with metformin. This may reflect uncertainty regarding the risk of acidosis in patients with chronic kidney disease.

Objective: To quantify the association between metformin use and hospitalization with acidosis across the range of estimated glomerular filtration rate (eGFR), accounting for change in eGFR stage over time. Read More

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Anatomic & metabolic brain markers of the m.3243A>G mutation: A multi-parametric 7T MRI study.

Neuroimage Clin 2018 31;18:231-244. Epub 2018 Jan 31.

Department of Cognitive Neuroscience, Maastricht University, PO Box 616, 6200MD Maastricht, Netherlands.

One of the most common mitochondrial DNA (mtDNA) mutations, the A to G transition at base pair 3243, has been linked to changes in the brain, in addition to commonly observed hearing problems, diabetes and myopathy. However, a detailed quantitative description of m.3243A>G patients' brains has not been provided so far. Read More

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January 2018

Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naïve patient: A case report.

Am J Emerg Med 2018 May 30. Epub 2018 May 30.

Department of Emergency Medicine, Regions Hospital, St Paul, MN, United States; Minnesota Poison Control Center, Minneapolis, MN, United States.

Metformin is a common and generally well-tolerated medication in the treatment of diabetes but rarely has been implicated as the cause for metformin-associated lactate acidosis. This is usually caused by decreased elimination from renal dysfunction but is rarely described after an acute ingestion. We present a case of an acute intentional overdose of metformin in a metformin-naïve patient without renal dysfunction. Read More

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Feeding corn grain steeped in citric acid modulates rumen fermentation and inflammatory responses in dairy goats.

Animal 2018 Jun 4:1-8. Epub 2018 Jun 4.

1Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition,College of Animal Science and Technology,Yangzhou University,Yangzhou,Jiangsu 225009,P.R. China.

Cereal grains treated with organic acids were proved to increase ruminal resistant starch and can relieve the risk of ruminal acidosis. However, previous study mainly focussed on acid-treated barley, the effects of organic acid-treated corn is still unknown. The objectives of this study were to evaluate whether feeding ground corn steeped in citric acid (CA) would affect ruminal pH and fermentation patterns, milk production and innate immunity responses in dairy goats. Read More

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MicroRNAs are inappropriate for characterising hearing impairment in mitochondrial disorders.

Orphanet J Rare Dis 2018 May 31;13(1):87. Epub 2018 May 31.

Pasteur Institute of Tunis, University of Tunis El Manar and Genomics Platform, Tunis, Tunisia.

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Hemoadsorption in a Case of Severe Septic Shock and Necrotizing Fasciitis Caused by Nontraumatic Renal Rupture due to Pyelonephritis with Obstructive Uropathy.

Case Rep Crit Care 2018 29;2018:5248901. Epub 2018 Apr 29.

Department of General and Visceral Surgery, Medical Center, University of Freiburg Faculty of Medicine, Freiburg, Germany.

Background: Nontraumatic renal rupture due to pyelonephritis with obstructive uropathy is an uncommon but life-threatening situation.

Case Presentation: A 25-year-old female presented to the emergency department with acute worsening of abdominal pain that began four weeks earlier. She was found to have peritonitis, leukocytosis, severe lactic acidosis, and a pronounced anemia and imaging was consistent with nontraumatic renal rupture with retroperitoneal abscess, perforation of the colon, and severe necrotizing fasciitis of the right lower limb. Read More

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April 2018
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Severe Metformin Poisoning Successfully Treated with Simultaneous Venovenous Hemofiltration and Prolonged Intermittent Hemodialysis.

Case Rep Crit Care 2018 8;2018:3868051. Epub 2018 May 8.

Department of Anaesthesiology and Intensive Care Medicine, Aalborg University Hospital, Aalborg, Denmark.

Metformin poisoning is a life-threatening condition with a high mortality rate. We present a patient case of metformin poisoning following intake of 80 g metformin resulting in severe lactate acidosis with a nadir pH of 6.73 and circulatory collapse, successfully treated with addition of prolonged intermittent hemodialysis (HD) to continuous venovenous hemofiltration (CVVH). Read More

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Significant Lactic Acidosis from Albuterol.

Clin Pract Cases Emerg Med 2018 May 14;2(2):128-131. Epub 2018 Mar 14.

University of Texas Southwestern, Department of Emergency Medicine, Dallas, Texas.

Lactic acidosis is a clinical entity that demands rapid assessment and treatment to prevent significant morbidity and mortality. With increased lactate use across many clinical scenarios, lactate values themselves cannot be interpreted apart from their appropriate clinical picture. The significance of Type B lactic acidosis is likely understated in the emergency department (ED). Read More

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May 2018
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Fatal Case of Metformin-Associated Lactic Acidosis Associated With Temporary Ileostomy: A Case Report.

J Wound Ostomy Continence Nurs 2018 May 24. Epub 2018 May 24.

Flavio Tirelli, MD, General Surgery Unit, Department of Surgery, "A. Gemelli" Foundation Policlinic Universitary, Catholic University of Rome, Rome, Italy. Alberto Biondi, MD, General Surgery Unit, Department of Surgery, "A. Gemelli" Foundation Policlinic Universitary, Catholic University of Rome, Rome, Italy. Roberto Persiani, MD, General Surgery Unit, Department of Surgery, "A. Gemelli" Foundation Policlinic Universitary, Catholic University of Rome, Rome, Italy.

Background: Metformin is considered a first choice for oral treatment of patients with type 2 diabetes in the absence of contraindications. Colorectal cancer is the second most frequent cancer among the general population; low anterior resections and temporary diverting ileostomies are commonly performed in this population. As the incidence of type 2 diabetes increases, the use of metformin in patients with both type 2 diabetes and an ileostomy will most likely increase as well. Read More

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May 2018
2 Reads

Lactic Acidosis and Asthma Exacerbation.

Arch Bronconeumol 2018 May 22. Epub 2018 May 22.

Sección de Neumología, Hospital General Universitario de Elche, Elche, Alicante, España; Departamento de Medicina Clínica, Universidad Miguel Hernández de Elche, Elche, Alicante, España. Electronic address:

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Metabolic acidosis in short bowel syndrome: think D-lactic acid acidosis.

BMJ Case Rep 2018 May 16;2018. Epub 2018 May 16.

Department of Gastroenterology, Royal Berkshire Hospital, Reading, UK.

Short bowel syndrome (SBS) is a condition when a person's gastrointestinal function is insufficient to supply the body with essential nutrients and hydration. Patients with SBS suffer from diarrhoea and symptoms of malabsorption such as weight loss, electrolyte disturbances and vitamin deficiencies. Long-term management of this condition can be complicated by the underlying disease, the abnormal bowel function and issues related to treatment like administration of parenteral nutrition and the use of a central venous catheter. Read More

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May 2018
6 Reads

ISCA1 Mutation In A Patient With Infantile-Onset Leukodystrophy Causes Defects In Mitochondrial [4Fe-4S] Proteins.

Hum Mol Genet 2018 May 14. Epub 2018 May 14.

Unit of Muscular and Neurodegenerative Disorders, Laboratory of Molecular Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Multiple Mitochondrial Dysfunction Syndromes (MMDS) comprise a group of severe autosomal recessive diseases characterized by impaired respiration and lipoic acid metabolism, resulting in infantile-onset mitochondrial encephalopathy, non-ketotic hyperglycinemia, myopathy, lactic acidosis and early death. Four different MMDS have been analyzed in detail according to the genes involved in the disease, MMDS1 (NFU1), MMDS2 (BOLA3), MMDS3 (IBA57), and MMDS4 (ISCA2). MMDS5 has recently been described in a clinical case report of patients carrying a mutation in ISCA1, but with no further functional analysis. Read More

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Multiorgan Failure and Refractory Lactic Acidosis due to Septicemia in a Patient with No Animal Exposure.

Case Rep Infect Dis 2018 22;2018:2574184. Epub 2018 Mar 22.

Division of Pulmonary and Critical Care Medicine, Bronx Lebanon Hospital Center Affiliated with Icahn School of Medicine at Mount Sinai, 1650 Grand Concourse, Bronx, NY 10457, USA.

Introduction: is a gram-negative coccobacillus pathogenic to animals. It can cause infection in humans by a bite, scratch, or lick from a cat or dog. can cause a variety of infections in humans, including cellulitis, osteomyelitis, endocarditis, peritonitis, and septic shock. Read More

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March 2018
3 Reads

[Dietetic treatment with fructose in a 5-year-old girl with recurrent D-lactic acidosis].

Nutr Hosp 2018 Mar 1;0(0):495-498. Epub 2018 Mar 1.

Servicio de Pediatría. Hospital Infantil Universitario Niño Jesús. Madrid..

D-lactic acidosis is an infrequent complication, mainly reported in patients with short bowel syndrome. It is characterized by recurrent episodes of encephalopathy with elevated serum D-lactic acid, usually associating metabolic acidosis. The presence of D-lactate-producing bacteria is necessary for the development of this complication. Read More

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Postanaesthetic shivering - from pathophysiology to prevention.

Rom J Anaesth Intensive Care 2018 Apr;25(1):73-81

Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, Clinic of Anaesthesia, University Hospital of Lucus Augusti, Lugo, Spain.

Postoperative shivering is a common complication of anaesthesia. Shivering is believed to increase oxygen consumption, increase the risk of hypoxemia, induce lactic acidosis, and catecholamine release. Therefore, it might increase the postoperative complications especially in high-risk patients. Read More

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Application of a Pharmacokinetic Model of Metformin Clearance in a Population with Acute Myeloid Leukemia.

J Res Pharm Pract 2018 Jan-Mar;7(1):41-45

Department of Pharmacy Practice, NYS Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, NY, USA.

Objective: We aimed to estimate the metformin-associated lactic acidosis (MALA) risk by assessing retrospectively the renal clearance variability and applying a pharmacokinetic (PK) model of metformin clearance in a population diagnosed with acute myeloid leukemia (AML) and diabetes mellitus (DM).

Methods: All adults with preexisting DM and newly diagnosed AML at Roswell Park Cancer Institute were reviewed (January 2003-December 2010, = 78). Creatinine clearance (CrCl) and total body weight distributions were used in a two-compartment PK model adapted for multiple dosing and modified to account for actual intra- and inter-individual variability. Read More

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CMT2 due to homozygous MFN2 variants is a multiorgan mitochondrial disorder.

Eur J Paediatr Neurol 2018 Apr 30. Epub 2018 Apr 30.

Disciplina de Neurociência, Escola Paulista de Medicina/Universidade Federal de São Paulo/. (EPM/UNIFESP), São Paulo, Brazil.

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April 2018
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Evaluating Mortality Risk Adjustment Among Children Receiving Extracorporeal Support for Respiratory Failure.

ASAIO J 2018 May 8. Epub 2018 May 8.

Division of Pediatric Critical Care, Emory University/Children's Healthcare of Atlanta, Georgia.

This study evaluates whether three commonly used pediatric intensive care unit (PICU) severity of illness scores, pediatric risk of mortality score (PRISM) III, pediatric index of mortality (PIM) 2, and pediatric logistic organ dysfunction (PELOD), are the appropriate tools to discriminate mortality risk in children receiving extracorporeal membrane oxygenation (ECMO) support for respiratory failure. This study also evaluates the ability of the Pediatric Risk Estimate Score for Children Using Extracorporeal Respiratory Support (Ped-RESCUERS) to discriminate mortality risk in the same population, and whether Ped-RESCUERS' discrimination of mortality is improved by additional clinical and laboratory measures of renal, hepatic, neurologic, and hematologic dysfunction. A multi-institutional retrospective cohort study was conducted on children aged 29 days to 17 years with respiratory failure requiring respiratory ECMO support. Read More

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May 2018
2 Reads

Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study.

PLoS One 2018 8;13(5):e0196122. Epub 2018 May 8.

Department of Emergency Medicine, Odense University Hospital, Odense, Denmark.

Background: Metformin constitutes first-line treatment of type 2 diabetes mellitus. It is presumed to have lactic acidosis as a dangerous, but rare, side effect.

Objectives: To estimate the incidence rate of lactic acidosis in patients with type 2 diabetes mellitus as well as to estimate the relative risk of lactic acidosis associated with metformin treatment. Read More

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[Regional citrate anticoagulation in renal replacement therapy in the intensive care station : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI].

Med Klin Intensivmed Notfmed 2018 06 8;113(5):377-383. Epub 2018 May 8.

Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland.

Background: Regional citrate anticoagulation (RCA) in continuous renal replacement therapy can effectively anticoagulate dialysis circuits without having adverse effects on systemic heparin application. In particular, in continuous renal replacement therapy RCA is well established and represents a safe procedure with longer filter lifetimes and fewer bleeding complications.

Objectives: To provide guidance on the indications, advantages and disadvantages, and use of RCA, current recommendations from the renal section of the DGIIN (Deutschen Gesellschaft für Internistische Intensivmedizin und Notfallmedizin), ÖGIAIN (Österreichischen Gesellschaft für Internistische und Allgemeine Intensivmedizin und Notfallmedizin) and DIVI (Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin) are stated. Read More

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Severe lactic acidosis in an extremely low birth weight infant due to thiamine deficiency.

J Pediatr Endocrinol Metab 2018 Jun;31(6):693-695

Department of Pediatrics, Division of Neonatology, Marmara University Faculty of Medicine, Istanbul, Turkey.

Background: In this case report, we present a preterm newborn with persistent lactic acidosis who received total parenteral nutrition (TPN) that lacked thiamine.

Case Presentation: A 28-week-old, 750 g female infant was born with an Apgar score of 8 at the 5th minute. Umbilical cord blood gas levels, including lactate level, were normal, and she was admitted to our neonatal intensive care unit (NICU). Read More

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June 2018
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Mutations in SURF1 are important genetic causes of Leigh syndrome in Slovak patients.

Endocr Regul 2018 Apr;52(2):110-118

Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.

Objectives: Leigh syndrome is a progressive early onset neurodegenerative disease typically presenting with psychomotor regression, signs of brainstem and/or basal ganglia disease, lactic acidosis, and characteristic magnetic resonance imaging findings. At molecular level, deficiency of respiratory complexes and/or pyruvate dehydrogenase complex is usually observed. Nuclear gene SURF1 encodes an assembly factor for cytochrome c-oxidase complex of the respiratory chain and autosomal recessive mutations in SURF1 are one of the most frequent causes of cytochrome c-oxidase-related Leigh syndrome cases. Read More

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April 2018
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Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis.

Mil Med Res 2018 Apr 26;5(1):13. Epub 2018 Apr 26.

Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing, 100850, China.

Type A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill patients. However, current therapeutic agents are still in shortage and can even be harmful. This paper reviewed data regarding lactic acidosis treatment and recommended that pyruvate might be a potential alkalizer to correct type A lactic acidosis in future clinical practice. Read More

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April 2018
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Lactobacilli Are Prominent Members of the Microbiota Involved in the Ruminal Digestion of Barley and Corn.

Front Microbiol 2018 10;9:718. Epub 2018 Apr 10.

Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada.

The chemical composition of barley grain can vary among barley varieties (Fibar, Xena, McGwire, and Hilose) and result in different digestion efficiencies in the rumen. It is not known if compositional differences in barley can affect the microbiota involved in the ruminal digestion of barley. The objective of this study was to characterize the rumen degradability and microbiota of four barley grain varieties and to compare these to corn. Read More

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Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog.

J Vet Emerg Crit Care (San Antonio) 2018 May 24;28(3):274-278. Epub 2018 Apr 24.

William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, Davis, CA, 95616.

Objective: To report a case of severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog.

Case Summary: A female neutered Rat Terrier was presented for an acute onset of seizure-like episodes, weakness, and vomiting approximately 14 hours after ingestion of 198 mg/kg of metformin. The dog was found to be laterally recumbent, paddling, and unresponsive shortly before presentation. Read More

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May 2018
2 Reads

[Metabolic lactic acidosis as a sign of voluntary poisoning in adolescents].

An Pediatr (Barc) 2018 Apr 20. Epub 2018 Apr 20.

Servicio de Urgencias, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España; Influencia del entorno en el bienestar del niño y del adolescente, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España. Electronic address:

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April 2018
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Extending the phenotypic spectrum of Sengers syndrome: Congenital lactic acidosis with synthetic liver dysfunction.

Transl Sci Rare Dis 2018 Apr 13;3(1):45-48. Epub 2018 Apr 13.

Children's National Health System, Rare Disease Institute, Genetics and Metabolism, Washington, DC, USA.

Sengers syndrome is a rare autosomal recessive mitochondrial disease characterized by lactic acidosis, hypertrophic cardiomyopathy and bilateral cataracts. We present here a case of neonatal demise, within the first day of life, who initially presented with severe lactic acidosis, with evidence of both chorioamnionitis and cardiogenic shock. Initial metabolic labs demonstrated a severe lactic acidosis prompting genetic testing which revealed a homozygous pathogenic variant for Sengers syndrome in c. Read More

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A neurodegenerative mitochondrial disease phenotype due to biallelic loss-of-function variants in PNPLA8 encoding calcium-independent phospholipase A2γ.

Am J Med Genet A 2018 May;176(5):1232-1237

Department of Medical Genetics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Animal studies have demonstrated the critical roles of the patatin-like protein family plays in cellular growth, lipid homeostasis, and second messenger signaling the nervous system. Of the nine known calcium-independent phospholipase A2γ, only PNPLA2, PNLPA6, PNPLA9 and most recently a single patient with PNPLA8 are associated with mitochondrial-related neurodegeneration. Using whole exome sequencing, we report two unrelated individuals with variable but similar clinical features of microcephaly, severe global developmental delay, spasticity, lactic acidosis, and progressive cerebellar atrophy with biallelic loss-of-function variants in PNPLA8. Read More

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LIPT1 deficiency presenting as early infantile epileptic encephalopathy, Leigh disease, and secondary pyruvate dehydrogenase complex deficiency.

Am J Med Genet A 2018 May;176(5):1184-1189

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

Lipoic acid is an essential cofactor for the mitochondrial 2-ketoacid dehydrogenase complexes and the glycine cleavage system. Lipoyltransferase 1 catalyzes the covalent attachment of lipoate to these enzyme systems. Pathogenic variants in LIPT1 gene have recently been described in four patients from three families, commonly presenting with severe lactic acidosis resulting in neonatal death and/or poor neurocognitive outcomes. Read More

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May 2018
2 Reads

Inflammatory mechanism of Rumenitis in dairy cows with subacute ruminal acidosis.

BMC Vet Res 2018 Apr 19;14(1):135. Epub 2018 Apr 19.

Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China.

Background: Subacute ruminal acidosis (SARA) is a metabolic disease in high-producing dairy cattle, and is accompanied by rumenitis. However, the mechanism of rumenitis remains unclear. Therefore, the aim of this study was to investigate the molecular mechanism of rumenitis in dairy cows with SARA. Read More

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April 2018
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Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial.

J Neurol Neurosurg Psychiatry 2018 Apr 17. Epub 2018 Apr 17.

Department of Neurology, Kawasaki Medical School, Kurashiki, Japan.

Objective: The aim of this study was to evaluate the efficacy and safety of high-dose taurine supplementation for prevention of stroke-like episodes of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes), a rare genetic disorder caused by point mutations in the mitochondrial DNA that lead to a taurine modification defect at the first anticodon nucleotide of mitochondrial tRNA, resulting in failure to decode codons accurately.

Methods: After the nationwide survey of MELAS, we conducted a multicentre, open-label, phase III trial in which 10 patients with recurrent stroke-like episodes received high-dose taurine (9 g or 12 g per day) for 52 weeks. The primary endpoint was the complete prevention of stroke-like episodes during the evaluation period. Read More

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April 2018
2 Reads

Acute Lymphoblastic Leukemia Presenting with Liver Infiltration and Severe Lactic Acidosis.

Am J Case Rep 2018 Apr 17;19:453-457. Epub 2018 Apr 17.

Department of Medicine, Division of Hematology/Oncology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

BACKGROUND Type-B lactic acidosis is a rare complication of solid tumors and hematological malignancies. It occurs secondary to Warburg effect, when glucose metabolism in cancer cells switches from the oxidative pathway to the glycolytic pathway. Malignant lactic acidosis is a life-threatening condition if not promptly diagnosed and treated urgently. Read More

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April 2018
1 Read

Pyruvate in reduced osmolarity oral rehydration salt corrected lactic acidosis in sever scald rats.

J Surg Res 2018 Jun 22;226:173-180. Epub 2018 Feb 22.

Shanghai Sandai Pharmaceutical R&D Co, Ltd, Pudong, Shanghai, China. Electronic address:

Background: A novel pyruvate-based oral rehydration salt (Pyr-ORS) was demonstrated of superiority over bicarbonate- or citrate-based one to preserve organ function and correct lactic acidosis in rehydration of lethal shock in animals. This study further compared these effects between low-osmolar Pyr-ORS and equimolar citrate-based counterpart.

Methods: Eighty rats, using a fatal burn shock model, were randomized into four groups (two subgroups per group: n = 10): the sham group (group SR), Pyr-ORS group (group PR), WHO-ORS III group (group CR), and no rehydration group. Read More

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June 2018
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Muscle Weakness, Cardiomyopathy, and L-2-Hydroxyglutaric Aciduria Associated with a Novel Recessive SLC25A4 Mutation.

JIMD Rep 2018 Apr 14. Epub 2018 Apr 14.

NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.

Background: Mutations in SLC25A4 (syn. ANT1, Adenine nucleotide translocase, type 1) are known to cause either autosomal dominant progressive external ophthalmoplegia (adPEO) or recessive mitochondrial myopathy, hypertrophic cardiomyopathy, and lactic acidosis.

Methods And Results: Whole exome sequencing in a young man with myopathy, subsarcolemmal mitochondrial aggregations, cardiomyopathy, lactic acidosis, and L-2-hydroxyglutaric aciduria (L-2-HGA) revealed a new homozygous mutation in SLC25A4 [c. Read More

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April 2018
2 Reads

On the Efficacy of Cardio-Pulmonary Resuscitation and Epinephrine Following Cyanide- and HS Intoxication-Induced Cardiac Asystole.

Cardiovasc Toxicol 2018 Apr 11. Epub 2018 Apr 11.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, College of Medicine, Pennsylvania State University, 500 University Drive, H041, Hershey, PA, 17033, USA.

This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (HS)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to either intravenous KCN (n = 27) or HS solutions (n = 12), at a rate that led to a PEA within less than 10 min. In the group intoxicated by CN, 20 rats were mechanically ventilated and received either epinephrine (0. Read More

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April 2018
3 Reads

Metformin-Induced Lactic Acidosis: A Case Study.

Cureus 2018 Feb 4;10(2):e2152. Epub 2018 Feb 4.

Assistant Clinical Professor of Internal Medicine, West Virginia University School of Medicine.

Metformin is the first line management for patients with Type 2 diabetes mellitus. Metformin-induced lactic acidosis (MALA) is a severe side effect of metformin in high doses. However, there have not been many reported cases of MALA. Read More

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February 2018

Population Pharmacokinetics of Intravenous Linezolid in Premature Infants.

Pediatr Infect Dis J 2018 Apr 9. Epub 2018 Apr 9.

Department of Pediatrics, CHU Sainte-Justine, Montreal, Canada.

Background: The emergence of coagulase-negative staphylococci (CoNS) with reduced vancomycin-susceptibility in some neonatal intensive care units (NICU) has resulted in an increase of linezolid use. Linezolid pharmacokinetics (PK) and safety in premature infants still need to be better established.

Methods: This was a retrospective PK study. Read More

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