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Am J Dermatopathol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Abstract: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade adnexal malignancy with a predilection for the eyelids of elderly White women, which is associated with invasive mucinous carcinoma with endocrine features in one-third of cases. EMPSGC is characterized by the presence of neuroendocrine differentiation and mucin production. However, EMPSGC displays a variety of architectural patterns including solid, cribriform, papillary, and cystic growth. Read More

Acta Radiol 2021 May 31:2841851211021039. Epub 2021 May 31.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, PR China.

Background: Little is known about the value of dynamic contrast-enhanced (DCE) in combination with diffusion-weighted imaging (DWI) for the differentiation of lacrimal gland tumors.

Purpose: To evaluate the ability of DCE and DWI in differentiating lacrimal gland tumors.

Material And Methods: DCE and DWI were performed in 72 patients with lacrimal gland tumors. Read More

BMJ Case Rep 2021 May 24;14(5). Epub 2021 May 24.

Department of Neurosciences, Faculty of Medicine and Surgery, University of Padova, Padova, Italy.

Epiphora is the first symptom of acquired nasolacrimal duct obstruction (NLDO), which may be due to various causes, including paranasal sinuses and tumours of the nasal cavity. A 28-year-old male patient presented chronic dacryocystitis with left-sided epiphora. Endoscopically, a bulging of the lateral nasal wall at the left-sided agger nasi area was noted. Read More

BMJ Case Rep 2021 May 21;14(5). Epub 2021 May 21.

Department of ENT and Head and Neck Surgery, Apollo Specialty Cancer Hospital, Chennai, Tamil Nadu, India.

The objective of this article is to elucidate on our experience with the first case reported in the literature of a synchronous presentation of pleomorphic adenoma (PA) in infratemporal fossa as well as the contralateral submandibular gland. PA most commonly arises from the major salivary glands but has also been reported to arise from minor salivary glands in unusual sites such as the nasal septum, main stem bronchus, trachea, lacrimal gland, external auditory canal, etc. However, it seldom involves the infratemporal fossa and extremely few cases are reported in the literature and coexistent contralateral synchronous PA is nowhere reported in literature. Read More

Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3S):S119-S120

Am J Dermatopathol 2021 May 11. Epub 2021 May 11.

Virginia Tech Carilion School of Medicine, Roanoke, VA; Dermatology Section, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA; Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA; and Oculofacial Plastic and Reconstructive Surgery, Vistar Eye Center, Roanoke, VA.

Abstract: Oncocytomas are benign neoplasms that are most often found in the salivary glands and kidneys. Ocular oncocytoma typically present as an asymptomatic dark blue papule on the lacrimal caruncle. Histologically, the tumor is composed of oncocytes, cells notable for eosinophilic cytoplasmic granules representing large quantities of dysfunctional mitochondria. Read More

BMJ Case Rep 2021 May 7;14(5). Epub 2021 May 7.

Department of Ophthalmology, Addenbrooke's Hospital, Cambridge, UK.

A 35-year-old woman underwent left external dacryocystorhinostomy (DCR) following a recent bout of left acute dacryocystitis. She had a right DCR 14 years earlier. Her relatively young age of presentation prompted suspicion of secondary nasolacrimal duct obstruction and, although the left lacrimal sac appeared macroscopically normal peroperatively, a lacrimal sac biopsy was taken. Read More

Medicine (Baltimore) 2021 May;100(18):e25514

Department of Stomatology.

Rationale: Ectopic tooth is tooth erupting out of normal anatomical position. Ectopic tooth can occur in different positions, such as maxillary sinus and nasal cavity. In this article, we present a rare case of an ectopic tooth with a dentigerous cyst in the maxillary sinus compressing the nasolacrimal canal. Read More

Zhonghua Yan Ke Za Zhi 2021 May;57(5):372-374

Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai 054001, China.

A 3-month-old infant patient presented with a 1-week history of a quickly progressive mass in the left eye. A hard, irregularly shaped tumor was found in the superolateral orbit. B-scan showed an uneven hypoecho and an undefined lesion. Read More

Zhonghua Yan Ke Za Zhi 2021 May;57(5):366-371

Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin 300020, China.

To summarize the clinical and pathological characteristics of diffuse large B-cell lymphoma of ocular adnexal (OA-DLBCL). A retrospective case series study. Twenty-three cases of OA-DLBCL were collected in Tianjin Eye Hospital from January 2005 to December 2018. Read More

Radiother Oncol 2021 Apr 17;160:69-77. Epub 2021 Apr 17.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany; German Cancer Consortium (DKTK), partner site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address:

Background: The limited availability of proton beam therapy (PBT) requires individual treatment selection strategies, such as the model-based approach. In this study, we assessed the dosimetric benefit of PBT compared to photon therapy (XRT), analysed the corresponding changes in normal tissue complication probability (NTCP) on a variety of available models, and illustrated model-based patient selection in an in-silico study for patients with brain tumours.

Methods: For 92 patients treated at two PBT centres, volumetric modulated arc therapy treatment plans were retrospectively created for comparison with the clinically applied PBT plans. Read More

J Neurol Surg B Skull Base 2021 Feb 18;82(1):100-106. Epub 2021 Feb 18.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States.

Lacrimal gland lesions account for approximately 9 to 10% of all biopsied orbital masses. Potential causes include nongranulomatous and granulomatous inflammation, autoimmune disease, lymphoproliferative disorders, benign epithelial proliferation, malignant neoplasia, and metastatic disease. Inflammatory lesions and lymphoproliferative disorders are the most common and may be unilateral or bilateral; they may also be localized to the orbit or associated with systemic disease. Read More

Eur Arch Otorhinolaryngol 2021 Mar 24. Epub 2021 Mar 24.

Department of Head and Neck Surgery, Instituto Nacional de Cancerología (Mexico), Av San Fernando # 22 Col. Sección XVI, Tlalpan, 14080, Mexico City, Mexico.

Purpose: Salivary gland tumors are rare and include benign and malignant entities with different behavior and prognosis. Salivary gland carcinoma accounts for 0.2% of all cancers and 5-9% of head and neck carcinomas. Read More

Orbit 2021 Mar 22:1-6. Epub 2021 Mar 22.

Department of Ophthalmology, Clinica Consultores Oftalmológicos, Buenos Aires, Argentina.

Epithelial tumors of the lacrimal gland are rare and usually develop in the orbital lobe. We report the exceedingly rare occurrence of a primary adenoid cystic carcinoma in the palpebral lobe of the lacrimal gland. A 26-year-old female was referred for evaluation of a gradually enlarging mass in the lateral upper eyelid, previously diagnosed as a chalazion. Read More

Med Sci Monit 2021 Mar 19;27:e929152. Epub 2021 Mar 19.

Department of Ophthalmology, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China (mainland).

BACKGROUND Lacrimal gland pleomorphic adenoma (LGPA) is the most common clinically benign epithelial tumor of the lacrimal gland and is predominantly comprised of epithelial cells and interstitial components. At present, the exact pathogenesis of LGPA remains unclear. Previous research has indicated that the occurrence of LGPA may be related to excessive cell proliferation. Read More

Ophthalmic Plast Reconstr Surg 2021 Mar 8. Epub 2021 Mar 8.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Aims: To report the characteristics and long-term outcomes of patients presenting with carcinoma ex-pleomorphic adenoma (CXPA) or malignant mixed tumor of the lacrimal gland.

Methods: A retrospective case-note review for patients with CXPA, seen at Moorfields Eye Hospital between 1985 and 2018, was performed for demographics, presentation, imaging, histopathology, management, and outcome.

Results: Twenty-six patients (11 male; 42%) presented at a mean age of 46 years (median 46. Read More

Acta Ophthalmol 2021 Mar 6. Epub 2021 Mar 6.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Adenoid Cystic Carcinoma (ACC) is an aggressive malignant lacrimal gland tumour associated with poor prognosis. Aberrant Notch signalling has been investigated in various tumours. However, very few studies on Notch signalling in lacrimal gland ACC are reported. Read More

Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):188-189

Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):188

Ann Plast Surg 2021 03;86(3):292-297

From the Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.

Introduction: Tumors involving the lacrimal drainage apparatus can be effectively treated with oncologic eye-sparing resection, immediate reconstruction, and adjuvant radiation. The extirpative technique is well described, whereas the reconstructive approach and outcomes are limited and largely anecdotal. The present study describes the largest series in the literature evaluating outcomes after reconstruction after globe-preserving oncologic resection. Read More

J Surg Oncol 2021 Apr 1;123(5):1246-1252. Epub 2021 Feb 1.

Department of Oral and Maxillofacial Surgery, University Hospital of Giessen and Marburg, Campus Marburg, UKGM GmbH, Faculty of Medicine, Philipps-University of Marburg, Marburg, Germany.

Purpose: The aims of the study were to estimate the frequency of epiphora and to identify factors associated with epiphora after orbital-sparing maxillectomy via modified Weber-Ferguson incision with lower blepharoplasty (OSOSM-MWFILB).

Methods: We performed a retrospective cohort study enrolling a sample derived from the patient population undergoing OSM-MWFILB over a 7-year period. The predictor variables were grouped into demographic, related health status, anatomic, tumor-specific, and therapeutic categories. Read More

Klin Monbl Augenheilkd 2021 Jan 27;238(1):48-54. Epub 2021 Jan 27.

Klinik für Augenheilkunde, Universitätsklinikum Münster, Deutschland.

Introduction: The LacriJet (FCI S. A. S. Read More

Radiother Oncol 2021 04 19;157:15-23. Epub 2021 Jan 19.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; German Cancer Consortium (DKTK), partner site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany. Electronic address:

Background: The limited availability of proton beam therapy (PBT) requires individual treatment selection strategies that can be based on normal tissue complication probability (NTCP) models. We developed and externally validated NTCP models for common late side-effects following PBT in brain tumour patients to optimise patients' quality of life.

Methods: Cohorts from three PBT centres (216 patients) were investigated for several physician-rated endpoints at 12 and 24 months after PBT: alopecia, dry eye syndrome, fatigue, headache, hearing and memory impairment, and optic neuropathy. Read More

Cancer Med 2021 02 15;10(3):1120-1127. Epub 2021 Jan 15.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Aims: Adenoid cystic carcinoma (ACC) is a distinctive tumour. Limited studies involving a large population have reported multicentre systematic analyses of the clinical, pathological and immunohistochemical (IHC) features of ACC as well as the potential role of IHC markers in the prognosis of ACC.

Methods And Results: The clinical, histopathological and IHC data of 296 cases obtained from two tertiary hospitals were analysed. Read More

Orbit 2021 Jan 6:1-4. Epub 2021 Jan 6.

Orbital, Plastic and Lacrimal Clinic, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.

Lacrimal gland pleomorphic adenomas (LGPA) are benign mixed tumors. Diagnosis is based on clinical and radiological findings which usually prompts complete excision of the lesion to minimise recurrence and a cumulative risk of malignant transformation. Necrosis in pleomorphic adenoma has been rarely reported in salivary gland PA, either spontaneously or due to iatrogenic interventions. Read More

Head Neck Pathol 2021 Jan 4. Epub 2021 Jan 4.

Department of Neurosurgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

Adenoid cystic carcinoma (ACC) is a tumor of the exocrine glands that originates primarily from the minor and major salivary glands, nasopharynx, and lacrimal glands. ACC grows slowly but is locally aggressive and prone to recurrence. It is uncommon for ACCs to develop in the pituitary gland as a primary tumor. Read More

J Appl Clin Med Phys 2021 Jan 24;22(1):203-209. Epub 2020 Dec 24.

New York Proton Center, New York, NY, USA.

Purpose: A unique mantle cell lymphoma case with bilateral periorbital disease unresponsive to chemotherapy and with dosimetry not conducive to electron therapy was treated with pencil beam scanning (PBS) proton therapy. This patient presented treatment planning challenges due to the thin target, immediately adjacent organs at risk (OAR), and nonconformal orbital surface anatomy. Therefore, we developed a patient-specific bolus and hypothesized that it would provide superior setup robustness, dose uniformity and dose conformity. Read More

BMC Med Genomics 2020 12 12;13(1):188. Epub 2020 Dec 12.

Department of Dermatologic Surgery, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, Jiangsu, China.

Background: Linear nevus sebaceous syndrome (LNSS) is a rare genetic disease characterized by large linear sebaceous nevus typically on the face, scalp, or neck. LNSS could be accompanied by multisystem disorders including the central nervous system. Herein, we report gene mutational profile via whole exome sequencing of both lesional and non-lesional skin samples in a LNSS patient. Read More

BMC Ophthalmol 2020 Dec 10;20(1):486. Epub 2020 Dec 10.

Department of Ophthalmology, Chang Gung Memorial Hospital, No. 6, West section, Chia-Pu RoadPu-Zih City, Chia-Yi County, Taiwan.

Background: Chorioretinal fold (CFs) is a rare condition resulting from undulations in the choriocapillaris, Bruch's membrane, retinal pigment epithelium and occasionally neurosensory retina. It can be idiopathic or due to different etiologies. The use of spectral-domain optical coherence tomography (SD-OCT) has increased the diagnosis of CFs and helped in differentiation from other etiologies. Read More

Cesk Slov Oftalmol 2020 ;76(4):146-157

Aim: To report an overview of the most frequent tumors of the orbit, suggest diagnostic approach and possible solution according to experience with own cohort of patients.

Material And Methods: From patients files from the Department of Ophthalmology and Department of Stomatology, First Medical Faculty, Charles University, and General Faculty Hospital in Prague, Czech Republic, there were selected patients, who underwent the surgery due to the suspicion of malignant development in the orbit during the period 2005 - 2019. From the surgical records we found information about 497 cases. Read More