Search Our Scientific Publications & Authors

Orbit 2022 May 29. Epub 2022 May 29.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Our goal is to contribute to the medical literature with our case of CEPA and hope to better help fellow clinicians diagnose and treat these rare tumors. Read More

Hum Pathol 2022 May 24;126:87-99. Epub 2022 May 24.

Department of Pathology, A.C.Camargo Cancer Center, Sao Paulo, 01509-010, Brazil. Electronic address:

NUT carcinoma (NC) is a rare malignancy with aggressive clinical behavior, defined by rearrangements involving the NUTM1 gene locus. This entity is often under-recognized and its diagnosis may be challenging. In this study, we describe a subset of patients that, despite the molecularly proven diagnosis of NC, show improved outcomes. Read More

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Department of Pathology, Prolife Diagnostics, Bhubaneswar, Odisha, India.

Swellings in medial canthal area in eye most often involve the lacrimal sac, the commonest aetiology being chronic dacryocystitis. Very rarely, there is a deviation in the routine diagnosis when the pathology comes out to be a lacrimal sac tumour. We report the case of a young man who presented with a medial canthal mass not extending above the medial canthal ligament. Read More

BMJ Case Rep 2022 May 13;15(5). Epub 2022 May 13.

Radiodiagnosis, Datta Meghe Institute of Medical Sciences - Wardha Campus, Wardha, Maharashtra, India.

Adenoid cystic carcinoma is an uncommon tumour of the salivary glands, although affliction of mucin-producing glands present in the oral cavity, oropharynx and paranasal sinuses is not uncommon. Other possible sites are lacrimal, oesophagus, trachea-bronchial tree, lungs, uterus, cervix, prostate. These tumours have a tendency to be aggressive and most show invasion into the adjacent region. Read More

Ophthalmic Plast Reconstr Surg 2022 May 13. Epub 2022 May 13.

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

Aims: To estimate the proportion of de novo lacrimal gland pleomorphic adenomas (PAs) and carcinomas expleomorphic adenomas (CEPAs), together with age at presentation and first symptom. Conjectural models of tumor growth are considered.

Methods: Retrospective review of patients with orbital lobe PA or CEPA. Read More

J Avian Med Surg 2022 May;36(1):78-84

Small Animal Clinic, Freie Universität Berlin, 14163 Berlin, Germany,

A free ranging, fledged common buzzard () was found with severe feather damage and left periorbital swelling. Clinical examination revealed a 3.0 × 2. Read More

Br J Radiol 2022 Jul 19;95(1135):20211333. Epub 2022 May 19.

Department of Diagnostic Radiology, McGill University Health Centre, Montreal, Quebec, Canada.

The lacrimal gland is a bilobed serous gland located in the superolateral aspect of the orbit. Lacrimal system pathologies can be broadly divided into pathologies of the lacrimal gland and those of the nasolacrimal drainage apparatus. These include distinct congenital, infectious, inflammatory, and benign, indeterminate, and malignant neoplastic lesions. Read More

Am J Otolaryngol 2022 May-Jun;43(3):103457. Epub 2022 Apr 6.

Division of Otolaryngology-Head and Neck Surgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; Center for Head and Neck Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

Most human papillomavirus (HPV)-positive carcinomas of unknown primary (CUP) in the cervical lymph nodes are ultimately found to arise from the oropharynx, which has by far the highest prevalence of HPV-positivity among head and neck tumors. However, HPV is also detected in a subset of tumors from other sites. In this case report, we describe the first reported instance of a lacrimal sac carcinoma presenting as an HPV-positive CUP. Read More

Exp Eye Res 2022 Jun 7;219:109067. Epub 2022 Apr 7.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, China. Electronic address:

The lacrimal gland adenoid cystic carcinoma (LACC) is a major orbital malignancy. The recurrence rate and mortality rate are higher in high proliferation LACC(HP-LACC) compared with low proliferation LACC(LP-LACC). In this study, miRNA microarray was used to explore the differentially expressed miRNAs profiling between HP-LACC and LP-LACC and its potential signaling pathway. Read More

Exp Eye Res 2022 Jun 26;219:109052. Epub 2022 Mar 26.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, PR China. Electronic address:

Lacrimal gland adenoid cystic carcinoma (ACC) is associated with high recurrence and mortality rates. Many recent studies have focused on the clinical features of the disease, and a better understanding of its underlying molecular mechanisms may help guide future treatment strategies. For proteomics quantitation, we analyzed normal tissues, benign tumor tissues and ACC tissues by LC-MS/MS with Tandem mass tags (TMTs) labeling. Read More

Orbit 2022 Mar 17:1-5. Epub 2022 Mar 17.

Department of Orbit and Oculoplasty, Aravind Eye Hospital and PG Institute of Ophthalmology, Madurai, India.

Epidermal nevus syndrome is a rare congenital disorder affecting only a few hundred people in the world. It has ophthalmic, dermatological, and neurological manifestations, with varied presentation. Here, we report a case of two-year-old child who presented with epibulbar mass in left eye, pigmented nevi over left side of the body and alopecia over left side of parieto-temporal scalp. Read More

GMS Ophthalmol Cases 2022 25;12:Doc06. Epub 2022 Feb 25.

University of the Philippines - Philippine General Hospital, Department of Ophthalmology and Visual Sciences, Manila, Philippines.

Lymphoproliferative disorders are a group of lesions characterized by abnormal proliferation of lymphocytes. In the orbit, they can occur in the ocular adnexae. These neoplasms have defined clinical and pathologic characteristics and account for more than 20% of all orbital tumors. Read More

Am J Ophthalmol 2022 Jul 12;239:170-179. Epub 2022 Mar 12.

From the Department of Pathology, Eye and ENT Hospital, Fudan University (H.S., R.C., C.Z., W.S., J.S., Y.B.). Electronic address:

Purpose: In this study, we evaluated the clinicopathologic and molecular characteristics of lacrimal apparatus mucoepidermoid carcinoma (MEC) to define its typical diagnostic features.

Design: Retrospective observational case series.

Methods: Institutional pathology records between 2011 and 2021 were searched for all cases of lacrimal apparatus MEC. Read More

Cancer Manag Res 2022 6;14:1023-1032. Epub 2022 Mar 6.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, 100730, People's Republic of China.

Purpose: Adenoid cystic carcinoma (ACC) of the lacrimal gland (LGACC) is an aggressive malignant lacrimal gland tumor with a generally poor prognosis. Survival rates for LGACC are 56% at 5 years and 49% at 10 years. Recent studies have indicated that anti-vascular endothelial growth factor (VEGF) therapy can inhibit angiogenesis in ACC cells. Read More

Cancers (Basel) 2022 Feb 25;14(5). Epub 2022 Feb 25.

Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, 69317 Lyon, France.

The eye is an exemplarily challenging organ to treat when considering ocular tumors. It is at the crossroads of several major aims in oncology: tumor control, organ preservation, and functional outcomes including vision and quality of life. The proximity between the tumor and organs that are susceptible to radiation damage explain these challenges. Read More

Neurol India 2022 Jan-Feb;70(1):296-299

Department of Neurosurgery, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Only three cases of pleomorphic adenomas (PAs) of ectopic lacrimal gland mass in deep orbital location have been reported in the literature. This report describes a case of PA of the ectopic lacrimal gland situated deep in the orbit leading to proptosis, which was managed successfully by supraorbital orbitotomy via eyebrow incision. A 60-year-old female presented with complaints of gradually progressive, painless proptosis of the right eye. Read More

Radiographics 2022 May-Jun;42(3):880-897. Epub 2022 Mar 4.

From the Departments of Radiology (A.K.J., J.B.G., L.J.E., G.B.L., J.C.B., W.B., V.M.S.), Ophthalmology (L.A.D.), Neurology (G.F.K.), Neurosurgery (W.B.), and Radiation Oncology (N.N.L.), Mayo Clinic, 200 1st St SW, Rochester, MN 55905.

Pediatric orbital masses are not common but encompass a wide spectrum of benign and malignant entities that range from developmental anomalies to primary and secondary orbital malignancies and metastatic disease. Certain orbital tumors are unique to pediatric patients, such as retinoblastoma and neuroblastoma. Clinical symptoms and signs are often insufficient to differentiate between orbital lesions, and imaging is essential for narrowing the diagnostic considerations and determining the most appropriate management strategy. Read More

Klin Onkol 2022 ;35(1):20-31

Background: IgG4 is the least represented subclass of human imunnoglobulines G (IgG) in serum and differs from other antibodies by its unique bio-logical properties. Although its function in the immune response is not entirely clear, it is mainly involved in the regulation of the immune response. It is formed as a result of chronic or strong antigenic stimulation; in such a case, it becomes a predominantly formed IgG subclass. Read More

Rare Tumors 2022 23;14:20363613221079763. Epub 2022 Feb 23.

Neurosurgery Unit, Department of Surgery, University of Nigeria Teaching Hospital Ituku/Ozalla Enugu, Enugu, Nigeria.

Background: Orbito-ocular tumors are rare, but they cause significant morbidity and mortality. There are reported variations in their pattern of presentation and frequency of occurrence.

Objective: To evaluate the occurrence, clinico-pathologic spectrum, and patterns of orbito-ocular neoplasms as well as the treatment and outcome profiles. Read More

BMJ Case Rep 2022 Feb 19;15(2). Epub 2022 Feb 19.

Department of Pathology, Faculty of Medicine, Kuwait University, Jabriyah, Kuwait

Giant cell-rich solitary fibrous tumour (GCR-SFT) is a rare variant of SFT with a predilection for the orbital region. Despite its hypervascularity, extensive angiomatoid cystic changes are unusual in GCR-SFT and may pose a diagnostic challenge. A 47-year-old man presented with a right eye proptosis and a protruding tumour of several years' duration with recently accelerated tumour growth. Read More

Thyroid 2022 05 22;32(5):483-485. Epub 2022 Mar 22.

Division of Endocrinology, Georgetown University, Washington, District of Columbia, USA.

Auris Nasus Larynx 2022 Jan 31. Epub 2022 Jan 31.

Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama 641-0012, Japan.

Salivary duct repositioning is often performed after excision of malignant tumors or removal of sialoliths to maintain salivary function and minimize the risk of swelling or pain due to the obstruction of the gland. However, there is risk of intraoperative tissue damage due to traumatic manipulation, leading to stenosis; in addition, the small diameter of the duct also renders this procedure difficult. Recently, we improved our method of salivary duct repositioning as follows. Read More

Ophthalmic Plast Reconstr Surg 2022 May-Jun 01;38(3):e93. Epub 2022 Jan 27.

Govindram Seksaria Institute of Dacryology, Ophthalmic Plastic Surgery Services, LV Prasad Eye Institute, Hyderabad, Telangana, India.

J Fr Ophtalmol 2022 06 25;45(6):e274-e276. Epub 2022 Jan 25.

Service d'anatomopathologie, centre hospitalier universitaire Mohammed VI, BP2360 Principal, Avenue Ibn Sina, Marrakech, Maroc.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211067894

Department of Hematology/Oncology, Kurashiki Central Hospital, Japan.

IgG4-related disease is a recently established clinical entity. The disease might serve as the background for later development of systemic lymphoma. This study aims to confirm the diagnosis of IgG4-related disease by re-staining lacrimal gland lesions diagnosed previously with low-grade lymphoma in a patient who developed systemic diffuse large B-cell lymphoma (DLBCL) 18 years later. Read More

Ophthalmic Plast Reconstr Surg 2022 May-Jun 01;38(3):e75-e77. Epub 2022 Jan 13.

Department of Ophthalmology, Duke University, Durham, North Carolina, U.S.A.

Primary ductal adenocarcinoma of the lacrimal gland is a rare, aggressive malignancy that clinically and histologically resembles salivary duct carcinoma. Similar to other malignant epithelial lacrimal gland tumors, ductal adenocarcinoma typically presents with unilateral proptosis, pain, upper eyelid swelling, palpable mass, diplopia, ptosis, and blurred or decreased vision. Rarely, primary malignant epithelial lacrimal gland tumors may first present with multiple cranial neuropathies due to occult spread to the cavernous sinus, as in this case. Read More

Arch Iran Med 2021 Dec 1;24(12):910-915. Epub 2021 Dec 1.

Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: The purpose of this study was to describe the radiologic and histopathologic features of lacrimal gland in patients presenting with lacrimal gland enlargement.

Methods: We retrospectively retrieved the data of patients with lacrimal gland enlargement in Farabi Eye Hospital between 2012 and 2017. These data included demographics, the patients' facial photographs, orbital CT-scans, and histopathological findings of lacrimal gland biopsies. Read More

Lasers Med Sci 2022 Jun 6;37(4):2287-2291. Epub 2022 Jan 6.

Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Sheng Li Road, Tainan, Taiwan, 704.

Literature on lacrimal punctal tumors is limited due to their rarity. Our aim in this study was to evaluate the clinicopathological characteristics of these tumors and assess functional and aesthetic outcomes after CO laser ablation with silicone stent intubation. A retrospective consecutive study was conducted from December 2013 to November 2020. Read More