1,111,657 results match your criteria Labor and Delivery in the Emergency Department
Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):351-352. Epub 2018 Dec 12.
Thorac Cardiovasc Surg 2018 Nov 12;66(8):607. Epub 2018 Dec 12.
Department of Cardiac, Thoracic and Vascular Surgery, Universitaetsmedizin Mainz, Mainz, Germany.
J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.
J. Craig Venter Institute, Rockville, MD USA.
Capsular polysaccharides have been confirmed to be an important virulence trait in many different Gram-positive and Gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In this study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. Read More
Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.
Department of Molecular Biosciences and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA.
Intrinsically disordered regions (IDRs) are present in at least 30% of the eukaryotic proteome and are enriched in chromatin-associated proteins. Using a combination of genetics, biochemistry and single-molecule biophysics, we characterize how IDRs regulate the functions of the yeast MutLα (Mlh1-Pms1) mismatch repair (MMR) complex. Shortening or scrambling the IDRs in both subunits ablates MMR in vivo. Read More
20 Century Br Hist 2018 Dec 11. Epub 2018 Dec 11.
Cardiff University, UK.
This article explores working-class women's experiences of political activism in the Labour Party in the 1930s. The article focuses upon the relationships formed with leaders, the bonds with fellow women, and the emotional fulfilment politics could bring, rather than considering the policies and campaigns which drew women into the party. It suggests how working-class women performed a political self which was shaped by but distinctive from a domestic self. Read More
Eur J Public Health 2018 Dec 11. Epub 2018 Dec 11.
Labour Law and Social Policy Department, Tilburg Law School, Tilburg University, Tilburg, The Netherlands.
Our study examines the relationship between the cumulation of employment statuses such as temporary contracts, self-employed, work at home or participating in the business activity of the spouse, and the health of Dutch early career workers. We followed four cohorts of Dutch early career workers that entered the labour market in 2002, 2004, 2006 and 2008 for a period of six years. Based on our fixed effects models, we conclude that men but not women who during their first six years of labour market participation experienced more spells of atypical employment also reported worse self-rated health. Read More
Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.
Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Kettegård Allé 26, Hvidovre, Denmark.
Study Question: Is the number of aspirated oocytes in the first ART cycle associated with the cumulative live birthrates (CLBR) in subsequent cycles?
Summary Answer: The number of aspirated oocytes in the first cycle was associated with CLBR in subsequent cycles. Previous treatment response predicts outcome in future cycles.
What Is Known Already: Previous reports have shown a positive association between the number of retrieved oocytes and live birthrate per fresh treatment cycle. Read More
J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.
Hôpital Necker Enfants Malades Université Sorbonne Paris Cité, Paris, APHP.
Exclusive Enteral Nutrition (EEN) is as efficacious as corticosteroids (CS) to induce remission in Crohn's disease (CD), without their adverse effects. EEN seems to be more efficient than steroids to induce mucosal healing, but the underlying molecular mechanisms are only sparsely understood. We aimed in the present work to study the anti-inflammatory effects of EEN with Modulen IBD® versus CS in active pediatric CD and to assess its modulatory effects on the intestinal microbiota as compared to steroids. Read More
Phys Med Biol 2018 Dec 12. Epub 2018 Dec 12.
Center for Proton Therapy, Paul Scherrer Institute, WMSA/C12, Villigen - PSI, 5232, SWITZERLAND.
Patient specific quality assurance is crucial to guarantee safety in proton pencil beam scanning. In current clinical practice, this requires extensive, time consuming measurements. Additionally, these measurements do not consider the influence of density heterogeneities in the patient and are insensitive to delivery errors. Read More
Phys Med Biol 2018 Dec 12. Epub 2018 Dec 12.
University of Wisconsin-Madison Department of Medical Physics, Madison, Wisconsin, UNITED STATES.
Longitudinal assessment of quantitative imaging biomarkers (QIBs) requires a comprehensive quality control (QC) program to minimize bias and variance in measurement results. In addition, the availability of data analysis software from multiple vendors emphasizes the need for a means of quantitatively comparing the computed QIB measures produced by the applications. The purpose of this work is to describe a digital reference object (DRO) that has been developed for the evaluation of arterial spin-labeling (ASL) measurement results. Read More
Phys Med Biol 2018 Dec 12. Epub 2018 Dec 12.
Department of Radiation Oncology, University of Texas Southwestern Medical Centre, Dallas, TX 75235, Dallas, Texas, 75205, UNITED STATES.
The aim of this work is to develop a novel recursive ensemble OARs segmentation (REOS) framework for accurate organs-at-risk (OARs) automatic segmentation. The REOS recursively segment individual OARs by ensembling images features extracted from an organ localization module and a contour detection module. Both modules are based on a 3D U-Net architecture. Read More
Stem Cell Reports 2018 Dec;11(6):1324-1326
San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan 20132, Italy. Electronic address:
Being able to summarize properly your work is not an easy task. But learning the skill of writing a good abstract is very important, as it can open many doors, including the possibility to be selected as a speaker at conferences. As meeting abstract reviewers, here we are writing to give you insights into the abstract review process and insiders' tips to help increase your chances of landing on that podium. Read More
Cell Rep 2018 Dec;25(11):2955-2962.e3
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:
Double homeobox (DUX) transcription factors are unique to eutherian mammals. DUX4 regulates expression of repetitive elements during early embryogenesis, but misexpression of DUX4 causes facioscapulohumeral muscular dystrophy (FSHD) and translocations overexpressing the DUX4 double homeodomain cause B cell leukemia. Here, we report the crystal structure of the tandem homeodomains of DUX4 bound to DNA. Read More
Ear Nose Throat J 2018 Dec;97(12):399-402
Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd., Stanford, CA 94035, USA.
Endoscopic technology is widely used in rhinology and anterior skull base surgery, but it has been less quickly incorporated into otologic practice. The design of the instrumentation forces surgeons to work one-handed and limits depth perception. Nevertheless, endoscopy also offers wide fields of view and access to spaces that are typically difficult to visualize. Read More
PLoS One 2018 12;13(12):e0208700. Epub 2018 Dec 12.
Avangrid Renewables, LLC, Portland, Oregon, United States of America.
Researchers typically conduct fatality monitoring to determine a wind energy facility's direct impacts on wildlife. In the United States, wind energy impacts on eagles have received increased attention in recent years because eagle incidental take permits became available. Permit holders are required to conduct fatality monitoring to evaluate compliance with permitted eagle take. Read More
PLoS One 2018 12;13(12):e0208796. Epub 2018 Dec 12.
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.
Background: The number of patients with diabetes is increasing particularly in Asia-Pacific region. Many of them are treated with antidiabetics. As the basis of the studies on the benefit and harm of antidiabetic drugs in the region, the information on patterns of market penetration of new classes of antidiabetic medications is important in providing context for subsequent research and analyzing and interpreting results. Read More
PLoS One 2018 12;13(12):e0207625. Epub 2018 Dec 12.
Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Münster, Germany.
Triclabendazole is a poorly-water soluble (0.24 μg/mL) compound classified into the Class II/IV of the Biopharmaceutical Classification System. It is the drug of choice to treat fascioliasis, a neglected parasitic disease worldwide disseminated. Read More
PLoS One 2018 12;13(12):e0208110. Epub 2018 Dec 12.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, United States of America.
The propensity for differentiation varies substantially across human pluripotent stem cell (hPSC) lines, greatly restricting the use of hPSCs for cell replacement therapy or disease modeling. Here, we investigate the underlying mechanisms and demonstrate that activation of the retinoblastoma (Rb) pathway in a transient manner is important for differentiation. In prior work, we demonstrated that pre-treating hPSCs with dimethylsulfoxide (DMSO) before directed differentiation enhanced differentiation potential across all three germ layers. Read More
PLoS One 2018 12;13(12):e0207846. Epub 2018 Dec 12.
Innlandet Hospital Trust, Department of Physical Medicine and Rehabilitation, Ottestad, Norway.
Objectives: To describe level of education and work participation among adults with congenital unilateral upper limb deficiency (CUULD) in Norway and to explore associations between work participation and demographic and clinical factors.
Methods: Cross-sectional study. In 2012, a postal questionnaire was sent to 186 persons with congenital limb deficiency (CLD), age ≥ 20 years, registered at the TRS National Resource Center for Rare Disorders. Read More
PLoS One 2018 12;13(12):e0208535. Epub 2018 Dec 12.
Department of Zoology, Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise, Tartu, Estonia.
Finding standard cost-effective methods for monitoring biodiversity is challenging due to trade-offs between survey costs (including expertise), specificity, and range of applicability. These trade-offs cause a lack of comparability among datasets collected by ecologists and conservationists, which is most regrettable in taxonomically demanding work on megadiverse inconspicuous taxon groups. We have developed a site-scale survey method for diverse sessile land organisms, which can be analyzed over multiple scales and linked with ecological insights and management. Read More
PLoS One 2018 12;13(12):e0207985. Epub 2018 Dec 12.
Apex Bait Technologies, Inc., Santa Clara, California, United States of America.
The German cockroach, Blatella germanica, is a common pest in urban environments and is among the most resilient insects in the world. The remarkable ability of the German cockroach to develop resistance when exposed to toxic insecticides is a prime example of adaptive evolution and makes control of this insect an ongoing struggle. Like many other organisms, the German cockroach is host to a diverse community of symbiotic microbes that play important roles in its physiology. Read More
PLoS One 2018 12;13(12):e0207633. Epub 2018 Dec 12.
University of California Davis, Department of Anthropology, Davis, CA, United States of America.
Active search for prey is energetically costly, so understanding how foragers optimize search has been central to foraging theory. Some theoretical work has suggested that foragers of randomly distributed prey should search using Lévy flights, while work on area-restricted and intermittent search strategies has demonstrated that foragers can use the information provided by prey encounters to more effectively adapt search direction and velocity. Previous empirical comparisons of these search modes have tended to rely on distribution-level analyses, due to the difficulty of collecting event-level data on encounters linked to the GPS tracks of foragers. Read More
PLoS One 2018 12;13(12):e0207881. Epub 2018 Dec 12.
LAI, Aix Marseille Univ, CNRS, INSERM, Marseille, France.
Macroscopic properties of physical and biological processes like friction, wetting, and adhesion or cell migration are controlled by interfacial properties at the nanoscopic scale. In an attempt to bridge simultaneously investigations at different scales, we demonstrate here how optical microscopy in Wet-Surface Ellipsometric Enhanced Contrast (Wet-SEEC) mode offers imaging and measurement of thin films at solid/liquid interfaces in the range 1-500 nm with lateral optical resolution. A live, label-free and noninvasive methodology integrated with microfluidic devices allowed here characterization of polymers and proteins patterns together with corresponding phenotypes of living cells. Read More
PLoS One 2018 12;13(12):e0207394. Epub 2018 Dec 12.
University of Science and Technology of China, Hefei, Anhui, China.
Background: The tension in doctor-patient relationships is becoming progressively greater due to the high expectations of patients and the physicians' work pressure. Recent studies have addressed factors which affect the tension of doctor-patient relationships, and our study continues this trend by looking at the influence of resiliency and physician trust in the patient (PTP), that is, how much the doctor trusts the patient.
Methods: Based on a survey of 329 physicians, a descriptive analysis of measured data was done using SPSS 19. Read More
PLoS Biol 2018 Dec 12;16(12):e2005956. Epub 2018 Dec 12.
Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi State, Mississippi, United States of America.
Plant protein kinases form redundant signaling pathways to perceive microbial pathogens and activate immunity. Bacterial pathogens repress cellular immune responses by secreting effectors, some of which bind and inhibit multiple host kinases. To understand how broadly bacterial effectors may bind protein kinases and the function of these kinase interactors, we first tested kinase-effector (K-E) interactions using the Pseudomonas syringae pv. Read More
Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.
Department of Orthopedic Surgery, Singapore General Hospital, Singapore.
Study Design: Retrospective study using prospectively collected registry data.
Objectives: The authors examine the influence of preoperative mental health on outcomes after anterior cervical discectomy and fusion (ACDF) and determine the impact of ACDF on postoperative mental health.
Summary Of Background Data: While studies have reported a negative correlation between preoperative mental health and outcomes following lumbar spine surgery, the influence on outcomes following cervical spine surgery remains relatively understudied. Read More
Nurs Res 2019 Jan/Feb;68(1):3-12
Ashley Schoenfisch, PhD, MSPH, is Assistant Professor, Duke University School of Nursing, and Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina. Kristen L. Kucera, PhD, MSPH, ATC, LAT, is Assistant Professor, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, and Director, National Center for Catastrophic Sport Injury Research, University of North Carolina at Chapel Hill. Hester J. Lipscomb, PhD, is Professor Emeritus, Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina. Jennifer McIlvaine, PT, MSPT, CSPHA, is Physical Therapist, Safe Patient Handling Specialist, Duke Occupational and Environmental Safety Office, Durham, North Carolina. Lori Becherer, BS, is Staff Specialist, Duke Occupational and Environmental Safety Office, Durham, North Carolina, and Injury Prevention Research Center, University of North Carolina at Chapel Hill. Tamara James, MA, CPE, CSPHP, is Director, Ergonomics, Duke Occupational and Environmental Safety Office, and Assistant Professor, Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina. Susan Avent, MSN, MBA, MHA, RN, NEA-BC, is Associate Chief Nursing Officer, Quality, Duke University Health System, Durham, North Carolina.
Background: Devices to lift, transfer, and reposition patients are recommended for healthcare workers' and patients' safety, but their intended use has yet to be fully realized.
Objective: The aim of this study was to describe hospital nursing staff use of lift/transfer devices and the presence of factors at the time of lifts/transfers with potential to influence whether devices are used.
Methods: Participants were 108 US nursing staff in a university-based medical center and two community hospitals. Read More
J Cardiovasc Pharmacol 2018 Dec 4. Epub 2018 Dec 4.
Department of Neurosurgery, Shanxi Provincial People's Hospital, Taiyuan City, Shanxi Province, China.
Our aim was to explore the efficacy of minimally invasive intervention in patients with acute cerebral infarction (ACI). Seventy patients with ACI were randomized into either an experimental group or a control group. In addition to the regular treatment, patients in the control group also received intravenous thrombolysis with urokinase, while patients in the other group underwent percutaneous transluminal cerebral angioplasty and stenting. Read More
J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.
University of Alberta, Edmonton, Canada.
Little is known about the dosing and tolerability of sacubitril/valsartan (LCZ696; Entresto™, Quebec, Canada) in a non-clinical trial population. This study was conducted to evaluate the use and tolerability of sacubitril/valsartan in patients followed at a multidisciplinary heart failure clinic. We performed a retrospective chart review of 126 patients with heart failure, initiated on sacubitril/valsartan, and seen at a specialty heart failure clinic between August 1, 2015 and August 1, 2017. Read More
J Hypertens 2018 Dec 11. Epub 2018 Dec 11.
Centre for Prevention of Stroke and Dementia, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Objectives: Vasodilating antihypertensives prevent stroke and potentially cerebral small vessel disease but their effects on cerebrovascular haemodynamics beyond blood pressure lowering are unclear.
Methods: We searched PubMed, Medline, Embase, Cinahl, Psychinfo, Health Business Elite and Health Management Information Consortium for randomized studies of vasodilating medications, compared to no treatment or nonvasodilators, that reported effects on cerebral blood flow (CBF), mean blood flow velocity (MFV) or cerebrovascular reactivity. Absolute and standardized mean differences (SMD) were combined by inverse-variance weighted fixed or random-effects meta-analysis stratified by study design, population characteristics and vasodilator class. Read More
J Hypertens 2018 Dec 11. Epub 2018 Dec 11.
Boehringer Ingelheim International GmbH, Ingelheim.
Objective: Concomitant treatment with angiotensin-converting enzyme (ACE) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors is increasingly common. Pharmacological studies have suggested a potential adverse drug interaction between ACE inhibitors and DPP-4 inhibitors resulting in unfavorable hemodynamic changes; very few studies have examined such an interaction between angiotensin II receptor blockers (ARBs) and DPP-4 inhibitors. We investigated blood pressure (BP) and heart rate (HR) during treatment with the DPP-4 inhibitor linagliptin in individuals receiving either ACE inhibitors or ARBs in the MARLINA-T2D trial. Read More
J Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.
Global Health Institute, Department of Epidemiology and Social Medicine, Faculty of Medicine and Health Sciences, University of Antwerp, Belgium (Mutambudzi); Department of Preventive Medicine & Community Health, University of Texas Medical Branch, Galveston, Texas (Mutambudzi); Stress Research Institute, Stockholm University, Stockholm, Sweden (Theorell); Institute of Occupational, Social, and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Germany (Li).
Objective: To examine the prospective associations between baseline job strain and ten-year cumulative incidence of long term sickness absence (LTSA) in the German workforce.
Methods: This study used longitudinal data from the 2001-2010 waves of The German Socio-Economic Panel (SOEP) (n = 9794). Kaplan-Meier survival curves and Cox proportional hazard regression models were used to examine the prospective association between job strain and incidence of LTSA. Read More
J Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.
Tufts University, Department of Occupational Therapy, Medford, MA (Marfeo); University of Pittsburgh, School of Health and Rehabilitation Sciences, Department of Physical Therapy (McDonough); Boston University School of Public Health, Department of Health Law Policy and Management, Boston, MA (Ni, Peterik, Kazis); National Institutes of Health Rehabilitation Medicine Department, Bethesda, MD (Porcino, Rasch, Chan); VHA Office of Reporting, Analytics, Performance, Improvement and Deployment (RAPID) (Meterko).
Objective: To further improve measurement of work-related physical and mental health by updating the Work Disability Assessment Battery (WD-FAB).
Methods: Cross-sectional study with 1024 disability claimants and 1000 working age (21-66 years) adults in the United States. Developed new items to replenish the WD-FAB and analyzed using factor analysis and item response theory (IRT). Read More
J Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.
Faculty of Health Medicine and Life Sciences, Maastricht University, Netherlands (Leitaru), Department of Health Promotion, School of Nutrition and Translational Research in Metabolism, Maastricht University, Netherlands (Kremers), Institute of Environmental Medicine, Karolinska Institutet, Sweden (Hagberg, Björklund, Kwak).
Objective: To examine the associations between work-stress and physical activity (PA) with sleep quality while controlling for covariates, including social support.
Methods: A cross-sectional study among employees of a municipality (n = 2765). Data from respondents (n = 1973) with good/poor sleep quality were included. Read More
Eur J Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.
From the Department of Anaesthesiology and Perioperative Medicine, Waitemata District Health Board (MUS, DAR, MTK), Health and Rehabilitation Research Institute, Auckland University of Technology (DAR, PJM), and Faculty of Medical and Health Sciences, University of Auckland (MTK).
Background: Early postoperative mobilisation is important for enhanced recovery, but can be hindered by orthostatic intolerance, characterised by dizziness, nausea, vomiting, feeling of heat, blurred vision and ultimately syncope. Although the incidence of orthostatic intolerance following total hip arthroplasty has been identified, few studies have yet investigated potential risk factors for developing orthostatic intolerance after hip arthroplasty.
Objectives: The aim of this study was to assess the incidence of orthostatic intolerance on the first postoperative day after total hip arthroplasty, potential predisposing risk factors for developing orthostatic intolerance and its effect on length of stay. Read More
Surg Laparosc Endosc Percutan Tech 2018 Dec 11. Epub 2018 Dec 11.
Department of Anorectal Surgery, First Affiliated Hospital of Nanjing University of Traditional Chinese Medicine (TCM), Qinhuai District, Nanjing, Jiangsu Province.
This meta-analysis aimed to compare the clinical outcomes of stapled hemorrhoidectomy (SH) and transanal hemorrhoidal dearterialization (THD) for treating hemorrhoidal disease. Randomized control trials (RCTs) comparing SH with THD were searched in databases, including MEDLINE, PubMed, Web of Science, EMBASE, and the Cochrane Library database. Nine RCTs, with 1077 patients, were included in this meta-analysis. Read More
J Am Assoc Nurse Pract 2018 Dec;30(12):696-709
Rush University College of Nursing, Chicago, Illinois.
Background And Purpose: Critical research topics were identified after nurse practitioner (NP) organization stakeholders participated in the Fellows of the American Association of Nurse Practitioner, 2015 Nurse Practitioner Research Agenda Roundtable. Strategies and recommendations were identified to support further work examining NP outcomes-based research priorities in four areas: 1) policy and regulation; 2) workforce; 3) education; and 4) practice. For the purpose of this article, we focus on NP education. Read More
Pain 2018 Dec 11. Epub 2018 Dec 11.
Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada, T6G 2E1.
Multiple Sclerosis (MS) is an inflammatory, neurodegenerative autoimmune disease associated with sensory and motor dysfunction. Although estimates vary, ∼50% of patients with MS experience pain during their disease. The mechanisms underlying the development of pain are not fully understood and no effective treatment for MS related pain is available. Read More
Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.
Department of Anesthesiology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
We surveyed Society of Cardiovascular Anesthesiologists members regarding anticoagulation practices for cardiopulmonary bypass and attitudes on heparin resistance. Of 550 respondents (18.5% response rate), 74. Read More
Clin J Pain 2018 Dec 11. Epub 2018 Dec 11.
The University of Queensland, School of Nursing, Midwifery and Social Work, St Lucia, QLD, Australia, 4072.
Objectives: The review article was designed to assess the effectiveness of regional anesthesia, specifically peripheral nerve blocks, in the treatment of burn pain; with noting of clinical indications and contraindications for peripheral nerve block application, along with discussion of evidence-based analgesic strategies for providing improved, comprehensive burn pain management.
Methods: A search of relevant literature was performed using CINAHL, PubMed, EMBASE, Web of Science and SCOPUS with a publication date between January 2005 and December 2017.
Results: The search yielded ten results that met criteria. Read More
Curr Opin Rheumatol 2018 Dec 11. Epub 2018 Dec 11.
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Purpose Of Review: The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity.
Recent Findings: Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis. Read More
Curr Opin Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.
Department of Anesthesiology.
Purpose Of Review: The current review focuses on precise anesthesia for video-assisted thoracoscopic surgery (VATS) with the goal of enhanced recovery.
Recent Findings: VATS has become an established and widely used minimally invasive approach with broad implementation on a variety of thoracic operations. In the current environment of enhanced recovery protocols and cost containment, minimally invasive VATS operations suggest adoption of individualized tailored, precise anesthesia. Read More
Curr Opin Organ Transplant 2018 Dec 11. Epub 2018 Dec 11.
Transplant Nephrology, Keck Hospital of USC, California, USA.
Purpose Of Review: Delayed graft function (DGF) has several long-term graft implications in the field of kidney transplantation and remains a challenge. The incidence of DGF is on the rise because of an increasing use of marginal kidneys in an era of organ shortage. Risk factors for DGF are numerous and stem from multiple sources in the transplant chain starting from the donor to its final allocation in the recipient. Read More
Mol Biol Cell 2018 Dec 12:mbcE18060358. Epub 2018 Dec 12.
Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD.
A dogma of innate immunity is that neutrophils use G-Protein-coupled receptors (GPCRs) for chemoattractant to chase bacteria through chemotaxis and then use phagocytic receptors coupled with tyrosine kinases to destroy opsonized bacteria via phagocytosis. Our current work showed that G-protein-coupled formyl peptide receptors (FPRs) directly mediate neutrophil phagocytosis. Mouse neutrophils lacking formyl peptide receptors (Fpr1/2) are defective in the phagocytosis of E. Read More
Mol Biol Cell 2018 Dec 12:mbcE18060345. Epub 2018 Dec 12.
Department of Molecular Biology and Biochemistry, Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, V5A 1S6, Canada.
Actomyosin contractility can influence the canonical Wnt signaling pathway in processes like mesoderm differentiation and tissue stiffness during tumorigenesis. We identified that increased non-muscle myosin II activation and cellular contraction inhibited Wnt target gene transcription in developing Drosophila imaginal discs. Genetic interactions studies were used to show that this effect was due to myosin-induced accumulation of cortical F-actin resulting in clustering and accumulation of E-cadherin to the adherens junctions. Read More
Mol Biol Cell 2018 Dec 12:mbcE18060402. Epub 2018 Dec 12.
Department of Biological Sciences, Dartmouth College, Hanover NH 03755, USA.
During the asymmetric division of the C. elegans zygote, germ (P) granules are disassembled in the anterior cytoplasm and stabilized/assembled in the posterior cytoplasm, leading to their inheritance by the germline daughter cell. P granule segregation depends on MEG-3 and MEG-4, which are enriched in P granules and in the posterior cytoplasm surrounding P granules. Read More
Brain Inj 2018 Dec 12:1-16. Epub 2018 Dec 12.
a Department of Physical Therapy , University of Toronto , Toronto , Canada.
Objective: Gait dysfunction is common following acquired brain injury (ABI). Clinical practice guidelines can improve patient outcomes; however, information regarding ABI-specific management of gait dysfunction is limited. This study aimed to describe practice patterns of Canadian physiotherapists regarding gait rehabilitation in adults post-ABI. Read More
J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.
Werner Reichardt Centre for Integrative Neuroscience, Germany.
Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well-studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular drifts, can be generated systematically. Read More
Evol Comput 2018 Dec 12:1-30. Epub 2018 Dec 12.
Institute of Computer Science, Czech Academy of Sciences, Pod Vodárenskou věží 2, 182 07 Prague, Czech Republic
This article deals with Gaussian process surrogate models for the Covariance Matrix Adaptation Evolutionary Strategy (CMA-ES)-several already existing and two by the authors recently proposed models are presented. The work discusses different variants of surrogate model exploitation and focuses on the benefits of employing the Gaussian process uncertainty prediction, especially during the selection of points for the evaluation with a surrogate model. The experimental part of the paper thoroughly compares and evaluates the five presented Gaussian process surrogate and six other state-of-the-art optimizers on the COCO benchmarks. Read More