2,501 results match your criteria Labor and Delivery Normal Delivery of the Newborn


Severe maternal infectious morbidity during the second half of pregnancy is an independent risk factor for a small for gestational age neonate.

Eur J Obstet Gynecol Reprod Biol 2022 Jul 30;274:238-242. Epub 2022 May 30.

Department of Obstetrics & Gynecology, Soroka University Medical Center, School of Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.

Objective: The effect of severe maternal infectious morbidity on fetal growth during the second half of pregnancy is under debate. Preliminary evidence suggests that such association may be plausible. The objectives of this study were to determine: 1) The association between severe maternal infectious morbidity and adverse pregnancy outcome; and 2) The effect of maternal infection during pregnancy on fetal growth. Read More

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Gestational age, birth weight, and perinatal complications in mothers with diabetes and impaired glucose tolerance: Japan Environment and Children's Study cohort.

PLoS One 2022 6;17(6):e0269610. Epub 2022 Jun 6.

Department of Health Sciences, University of Yamanashi, Chuo City, Yamanashi, Japan.

We aimed to determine the risk of perinatal complications during delivery in mothers with non-normal glucose tolerance in a large Japanese birth cohort. We analysed data of 24,295 neonate-mother pairs in the Japan Environment and Children's Study cohort between 2011 and 2014. We included 67 mothers with type 1 diabetes, 102 with type 2 diabetes (determined by questionnaire), 2,045 with gestational diabetes (determined by diagnosis), and 2,949 with plasma glucose levels ≥140 mg/dL (shown by a screening test for gestational diabetes). Read More

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Implementation of Delayed Cord Clamping in public health facilities: a case study from India.

BMC Pregnancy Childbirth 2022 Jun 1;22(1):457. Epub 2022 Jun 1.

Nutrition International, Ottawa, Canada.

Background: Global and country specific recommendations on Delayed umbilical cord clamping (DCC) are available, though guidance on their implementation in program settings is lacking. In India, DCC (clamping not earlier than 1 min after birth) is a component in the package of services delivered as part of the India Newborn Action Plan (INAP) supported by Nutrition International (NI) in two states. The objective of this case study was to document the learnings from implementation of DCC in these two states and to understand the health system factors that affected its operationalization. Read More

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Uterine activity in labour and the risk of neonatal encephalopathy: a case control study.

Eur J Obstet Gynecol Reprod Biol 2022 Jul 16;274:73-79. Epub 2022 May 16.

Department of Neonatology, Rotunda Hospital, Dublin, Ireland.

Objective: To determine the relationship between intrapartum contraction frequency, rest interval duration, and cervical dilation speed and the risk of neonatal hypoxic-ischemic encephalopathy (HIE).

Study Design: This was a retrospective case-control study conducted in a maternity hospital in Dublin, Ireland. Babies born without major congenital anomalies between September 2006 and November 2017 at ≥ 35 + 0 weeks' gestational age were eligible. Read More

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Association of Placental Parameters with Low Birth Weight Among Neonates Born in the Public Hospitals of Hadiya Zone, Southern Ethiopia: An Institution-Based Cross-Sectional Study.

Int J Gen Med 2022 16;15:5005-5014. Epub 2022 May 16.

Department of Nursing, College of Medicine and Health Sciences, Samara University, Samara, Ethiopia.

Introduction: Placenta indices are the significant determinants of perinatal outcome and neonatal mortality. A clinician can predict neonatal status based on the findings from the placental indices. However, there are limited studies on the relationship between placental parameters and neonatal birth weight in Ethiopia. Read More

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Fetal heart rate patterns in labor and the risk of neonatal encephalopathy: A case control study.

Eur J Obstet Gynecol Reprod Biol 2022 Jun 23;273:69-74. Epub 2022 Apr 23.

Department of Neonatology, Rotunda Hospital, Dublin, Ireland.

Objective: To describe the accuracy of intrapartum fetal heart rate abnormalities as defined by National Institute of Health and Care Excellence guidelines to predict moderate-severe neonatal encephalopathy of apparent hypoxic-ischemic etiology.

Study Design: A case-control study of HIE risk factors was conducted. Eligible babies were born in a single maternity hospital in Dublin, Ireland between September 2006, and November 2017 at ≥35 + 0 weeks' gestational age. Read More

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A prospective study of myeloperoxidase levels in water immersion.

Placenta 2022 06 22;123:1-4. Epub 2022 Apr 22.

Department of Obstetrics and Gynecology, Ankara Etlik Zubeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.

Introduction: We aimed to compare myeloperoxidase levels in cord blood samples of mothers undergoing water immersion or conventional labor.

Method: We enrolled 52 pregnant women to this case control study meeting the following criteria: uneventful gestational follow-ups, no history of known chronic or pregnancy-associated diseases, cesarean section or uterine operation, BMI <29.9 kg/m, single vertex presentation, normal fetal heart rate pattern, 37-41 weeks of gestation, estimated fetal weight of 2500-4000 g. Read More

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Implications of an Elevated Nucleated Red Blood Cell Count in Neonates with Moderate to Severe Hypoxic-Ischemic Encephalopathy.

J Pediatr 2022 Jul 14;246:12-18.e2. Epub 2022 Apr 14.

Obstetric and Neonatal Operations, Department of Neonatology, Intermountain Healthcare, Murray, UT; Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT.

Objectives: To investigate associations between nucleated red blood cell (NRBC) count in neonates with hypoxic-ischemic encephalopathy (HIE), acute perinatal sentinel events, and neurodevelopmental outcomes and to examine the mechanism(s) causing elevated counts.

Study Design: We included newborn infants with HIE treated with therapeutic hypothermia with ≥3 NRBC counts during their neonatal intensive care unit hospitalization and neurodevelopmental evaluations at a mean of 24 ± 6 months.

Results: Ninety-five of 152 infants who met our study criteria (63%) had a normal NRBC count after birth, defined as ≤95th percentile of the upper reference interval, and the other 57 (37%) had an elevated count. Read More

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Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol.

BMJ Open 2022 04 15;12(4):e055543. Epub 2022 Apr 15.

Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.

Introduction: Following the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring invariably leading to delivery. Indices derived from fetal cerebral Doppler examination may guide such decisions although there are few studies in this area. Read More

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The effect of celecoxib for treatment of preterm labor on fetuses during the second trimester of pregnancy: A pilot case series.

Taiwan J Obstet Gynecol 2022 Mar;61(2):277-281

Department of Gynecology and Obstetrics, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507 Japan.

Objective: Although cyclooxygenase inhibitors effectively suppress uterine contraction, constriction of the fetal ductus arteriosus (DA) and oligohydramnios are major concerns. Celecoxib, a selective cyclooxygenase 2 inhibitor, is a potential potent tocolytic agent, but there are no studies that have evaluated the beneficial or adverse effects of celecoxib use on fetuses for more than 48 hours in pregnant women. We therefore aimed to evaluate the effect of middle-long-term celecoxib administration on the fetus during the second trimester of pregnancy, particularly in terms of fetal DA and amniotic fluid volume. Read More

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AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency.

Thyroid 2022 May 20. Epub 2022 May 20.

The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Allan-Herndon-Dudley syndrome (AHDS) is a severe psychomotor disability disorder that also manifests characteristic abnormal thyroid hormone (TH) levels. AHDS is caused by inactivating mutations in monocarboxylate transporter 8 (MCT8), a specific TH plasma membrane transporter widely expressed in the central nervous system (CNS). mutations cause impaired transport of TH across brain barriers, leading to insufficient neural TH supply. Read More

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Does predelivery BMI really matter in pregnancy?

Ginekol Pol 2022 Mar 24. Epub 2022 Mar 24.

Department of Perinatology and Gynecology, Poznan University od Medical Sciences, Poland.

Objectives: The aim of the study was to compare the perinatal outcome between the normal weight, overweight and obese pregnant women who delivered in the third-level center of reference. Moreover, the objective was to analyze the usefulness of predelivery body mass index (BMI) in prediction of preterm delivery, prolonged second stage of labor, instrumental vaginal delivery, cesarean section, fetal macrosomia, dystocia and newborn acidosis.

Material And Methods: The retrospective study included 2104 patients, divided into three groups, with BMI between 18. Read More

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Transient Idiopathic Polyhydramnios: Maternal and Perinatal Outcomes: Maternal and Perinatal Outcomes.

J Ultrasound Med 2022 Mar 21. Epub 2022 Mar 21.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME, USA.

Objectives: To compare maternal and perinatal outcomes in pregnancies with transient and persistent idiopathic polyhydramnios to those with normal amniotic fluid volume.

Methods: This retrospective cohort study included subjects delivering a singleton pregnancy between January 1, 2015, and June 30, 2020, with sonography ≥26 weeks' gestation demonstrating transient or persistent idiopathic polyhydramnios (amniotic fluid index [AFI] ≥24.0 cm) or normal AFI (referent group). Read More

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Antenatal Doppler screening for fetuses at risk of adverse outcomes: a multicountry cohort study of the prevalence of abnormal resistance index in low-risk pregnant women.

BMJ Open 2022 03 16;12(3):e053622. Epub 2022 Mar 16.

UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.

Introduction: Few interventions exist to address the high burden of stillbirths in apparently healthy pregnant women in low- and middle-income countries (LMICs). To establish whether a trial on the impact of routine Doppler screening in a low-risk obstetric population is warranted, we determined the prevalence of abnormal fetal umbilical artery resistance indices among low-risk pregnant women using a low-cost Doppler device in five LMICs.

Methods: We conducted a multicentre, prospective cohort study in Ghana, India, Kenya, Rwanda and South Africa. Read More

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Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm.

Authors:
Ramkumar Menon

Immunol Rev 2022 07 14;308(1):149-167. Epub 2022 Mar 14.

Division of Basic Science and Translational Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch, Galveston, Texas, USA.

Human parturition at term and preterm is an inflammatory process synchronously executed by both fetomaternal tissues to transition them from a quiescent state t an active state of labor to ensure delivery. The initiators of the inflammatory signaling mechanism can be both maternal and fetal. The placental (fetal)-maternal immune and endocrine mediated homeostatic imbalances and inflammation are well reported. Read More

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The Application of Intrauterine Resuscitation Maneuvers in Delivery Room: actual and expected Use.

Midwifery 2022 Apr 8;107:103279. Epub 2022 Feb 8.

Department of Gynecology and Obstetrics, University of Piemonte Orientale, Ospedale Maggiore della Carità, Via Mazzini 28, 28100, Novara, Italy.

Background: In case of suspicious CTG in labor a conservative attitude is recommended, when possible, through intrauterine resuscitation maneuvers.

Aims: This study aims to evaluate the use of intrauterine resuscitation maneuvers (IRM) at two Italian hospitals; the secondary outcome is the assessment of the agreement in their application.

Materials And Methods: Retrospective analysis was performed on the data of 80 deliveries (40 vs 40) from two different Italian hospitals, located in Novara (group 1) and in Borgomanero (group 2). Read More

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Vitamin C and IL-6 in women with preterm premature rupture of membranes compared to normal pregnant women - a case-control study.

Authors:
Alaa Ibrahim Ali

J Pak Med Assoc 2021 Dec;71(Suppl 8)(12):S45-S48

Department of Obstetrics and Gynaecology, College of Medicine, Al Mustansiriyah University, Baghdad, Iraq.

Objective: The study assessed the relationship of plasma ascorbic acid (vitamin C) level and IL-6 with preterm premature rupture of membranes (PPROM) in pregnant women.

Methods: A case-control study was carried out in University Hospital, Baghdad from July 2019 to July 2020. Two groups of pregnant women with a gestational age between 28-36+6 weeks were included. Read More

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December 2021

Associations between prolonged second stage of labor and maternal and neonatal outcomes in freestanding birth centers: a retrospective analysis.

BMC Pregnancy Childbirth 2022 Feb 4;22(1):99. Epub 2022 Feb 4.

American Association of Birth Centers, 3123 Gottschall Road, Perkiomenville, PA, 18074, USA.

Background: Current guidelines for second stage management do not provide guidance for community birth providers about when best to transfer women to hospital care for prolonged second stage. Our goal was to increase the evidence base for these providers by: 1) describing the lengths of second stage labor in freestanding birth centers, and 2) determining whether proportions of postpartum women and newborns experiencing complications change as length of second stage labor increases.

Methods: This study is a retrospective analysis of de-identified client-level data collected in the American Association of Birth Centers Perinatal Data Registry, including women giving birth in freestanding birth centers January 1, 2007 to December 31, 2016. Read More

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February 2022

Programmed intermittent epidural bolus in parturients: A meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2022 Feb;101(5):e28742

Obstetrical Department of The First People's Hospital of Changde City, Changde, Hunan, China.

Background: To evaluate the efficacy and safety of programmed intermittent epidural bolus (PIEB) in parturients.

Methods: The PubMed, Embase, and the Cochrane Library (from inception to July 2021) were searched for identification of randomized placebo-controlled trials in which PIEB was applied in parturients. The outcomes were the effect of analgesia, satisfaction score, mode of delivery, duration of labor, neonatal condition, and adverse events. Read More

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February 2022

Cervicovaginal and rectal colonization by group B Streptococci in Mexican women with full-term pregnancies.

Gac Med Mex 2021 ;157(5):516-521

Infectious Diseases Research Unit, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Mexico City.

Background: A pregnant woman rectally or vaginally colonized by group B Streptococcus can infect her newborn.

Patients And Methods: Prospective, cross-sectional, analytical 24-month study in pregnant women. Women in labor with ≥ 36 weeks of gestation were included. Read More

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February 2022

Sickle cell disease and COVID-19 in pregnant women.

J Gynecol Obstet Hum Reprod 2022 Mar 29;51(3):102328. Epub 2022 Jan 29.

Department of Gynecology Obstetrics and Reproductive Medicine, Tenon Hospital, AP-HP, Sorbonne University, 4 rue de la Chine, Paris 75020, France.

Introduction: The effect of coronavirus disease (COVID-19) on pregnancy outcome in women with sickle cell disease (SCD) is unknown.

Objectives: To analyze the severity of the SARS-CoV-2 infection in pregnant women with SCD and its impact on pregnancy.

Methods: This retrospective cohort study included SCD pregnant women tested positive for COVID-19 between March 2020 - February 2021. Read More

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A systematic review and meta-analysis of women's satisfaction with skilled delivery care and the associated factors in Ethiopia.

SAGE Open Med 2022 21;10:20503121211068249. Epub 2022 Jan 21.

Department of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Evidence of variation in maternity health service practices has increased the government's interest in quantifying and advancing the quality of institutional delivery care in the developing world, including Ethiopia. Therefore, we conducted a systematic review and meta-analysis to update and provide more representative data on women's satisfaction with skilled delivery care and the associated factors in Ethiopia. This systematic review and meta-analysis followed the Preferred Reporting Items 2015 guideline. Read More

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January 2022

Concerns about the contemporary labor curves and guidelines: Is it time to revisit the old ones?

Eur J Obstet Gynecol Reprod Biol 2022 Mar 21;270:169-175. Epub 2021 Dec 21.

Serviço de Ginecologia e Obstetrícia, Centro Hospitalar e Universitário S. João, Portugal; Departamento de Ginecologia Obstetrícia e Pediatria, Faculdade de Medicina, Universidade do Porto, Portugal.

Background: One of the main reasons for the rising caesarean section rate is labor progression abnormalities. New guidelines were released promoting the changing paradigm from Friedman to Zhang's labor curves. However, the lack of evidence of its safety and the unclear effect on caesarean section rates have been challenging its adoption. Read More

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Does COVID-19 Policy Affect Initiation and Duration of Exclusive Breastfeeding? A Single-center Retrospective Study.

Risk Manag Healthc Policy 2022 14;15:27-36. Epub 2022 Jan 14.

Department of Clinical Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Purpose: It assessed the effect of a COVID-19 policy that involved maternal-neonatal separation on early initiation and duration of exclusive breastfeeding (EBF) at two weeks, three, and six months postpartum during the peak of the COVID-19 pandemic in 2020.

Patients And Methods: This retrospective study included consecutive mother-newborn dyads with deliveries between mid-March and the end of December 2020 who agreed to participate and were eligible according to the following criteria: full-term pregnancy, singleton birth, and healthy newborn. Participants were called at least twice during the study period to inquire about exclusive breastfeeding status at two weeks, three, and six months postpartum. Read More

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January 2022

Is there an optimal inter-delivery interval in women who underwent trial of labor after cesarean delivery (TOLAC)?

Reprod Health 2022 Jan 20;19(1):14. Epub 2022 Jan 20.

Foshan Fetal Medicine Institute, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Renminxi Road 11, Foshan, 528000, Guangdong, China.

Background: Inter-delivery interval (IDI) has been proven to be a factor associated with adverse maternal and neonatal outcomes. However, the optimal IDI in trial of labor after cesarean delivery (TOLAC) remains unclear. We aimed to investigate the association between IDI and major maternal and neonatal outcomes in women who underwent TOLAC. Read More

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January 2022

Manual fetal stimulation during intrapartum fetal surveillance: a randomized controlled trial.

Am J Obstet Gynecol MFM 2022 03 17;4(2):100574. Epub 2022 Jan 17.

and Department of Paediatrics, Pondicherry Institute of Medical Sciences, Puducherry, India (Dr Krishnan).

Background: Manual fetal stimulation, either by mechanical manipulation or by stimulation of the fetal scalp, is known to evoke a fetal heart response in a normal fetus.

Objective: This study aimed to assess the clinical effectiveness of manual fetal stimulation in the assessment of fetal well-being during labor vs no stimulation among women with a singleton pregnancy and to investigate the maternal and neonatal outcomes in the 2 groups.

Study Design: This was a randomized controlled trial conducted in the department of obstetrics and gynecology at a tertiary care teaching hospital between 2014 and 2016. Read More

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Impact of uterine malformations on pregnancy and neonatal outcomes of IVF/ICSI-frozen embryo transfer.

Hum Reprod 2022 Mar;37(3):428-446

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Study Question: What is the impact of uterine malformations on reproductive and neonatal outcomes of IVF/ICSI-frozen embryo transfer?

Summary Answer: Unification defective uteri are associated with poorer neonatal outcomes including higher preterm delivery rate and lower birthweight, and septate uteri are associated with worse fertility outcomes including higher miscarriage and lower live birth rates (LBRs).

What Is Known Already: Several studies have investigated the negative effects of uterine malformations on pregnancy outcomes. However, an all-round and definitive conclusion has not been reached yet owing to the relatively low incidence of the disease and the heterogeneity of study populations, especially among women undergoing ART. Read More

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Factors Associated With Normal Physiologic Birth for Women Who Labor In Water: A Secondary Analysis of A Prospective Observational Study.

J Midwifery Womens Health 2022 01 14;67(1):13-20. Epub 2022 Jan 14.

Faculty of Health Sciences, Hull University, Hull, United Kingdom.

Introduction: Research to understand factors associated with normal physiologic birth (unassisted vaginal birth, spontaneous labor onset without epidural analgesia, spinal, or general anesthetic, without episiotomy) is required. Laboring and/or giving birth in water has been shown to be associated with a high proportion of physiologic birth but with little understanding of factors that may influence this outcome. This study explored factors associated with normal physiologic birth for women who labored in water. Read More

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January 2022

Toxoplasmosis impact on prematurity and low birth weight.

PLoS One 2022 13;17(1):e0262593. Epub 2022 Jan 13.

OBGYN dpt. Amedeana, Prague, Czech Republic.

Background: Toxoplasma gondii, one of the most common parasites, causes toxoplasmosis, one of the most frequent zoonotic diseases worldwide. T. gondii infects about one-third of the world's population. Read More

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February 2022

Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze).

Hum Reprod 2022 Mar;37(3):476-487

Health Economics Research Unit, University of Aberdeen, Aberdeen, UK.

Study Question: Does a policy of elective freezing of embryos, followed by frozen embryo transfer result in a higher healthy baby rate, after first embryo transfer, when compared with the current policy of transferring fresh embryos?

Summary Answer: This study, although limited by sample size, provides no evidence to support the adoption of a routine policy of elective freeze in preference to fresh embryo transfer in order to improve IVF effectiveness in obtaining a healthy baby.

What Is Known Already: The policy of freezing all embryos followed by frozen embryo transfer is associated with a higher live birth rate for high responders but a similar/lower live birth after first embryo transfer and cumulative live birth rate for normal responders. Frozen embryo transfer is associated with a lower risk of ovarian hyperstimulation syndrome (OHSS), preterm delivery and low birthweight babies but a higher risk of large babies and pre-eclampsia. Read More

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