296,672 results match your criteria Lab on a Chip [Journal]


Edonerpic Maleate: A Promising Pharmacological Agent for Stroke Recovery.

Neurosurgery 2019 Jan;84(1):E3-E4

Department of Neurological Surgery Mayo Clinic Phoenix, Arizona.

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January 2019

Coupling interaction between porous biochar and nano zero valent iron/nano α-hydroxyl iron oxide improves the remediation efficiency of cadmium in aqueous solution.

Chemosphere 2018 Dec 7;219:493-503. Epub 2018 Dec 7.

College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China. Electronic address:

Based on the interaction between mesoscopic biochar materials and nanomaterials, the synergistic mechanism of the two materials in the process of cadmium remediation was studied. KCO activated porous biochar (KBC) loaded with nano-zero-valent iron (nZVI)/nano-α-hydroxy-iron oxide (nHIO) was studied. Macroscopically, batch adsorption experiments were carried out to describe the adsorption properties of the composites. Read More

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December 2018

Deficits in rate of torque development are accompanied by activation failure in patients with knee osteoarthritis.

J Electromyogr Kinesiol 2018 Dec 4;44:94-100. Epub 2018 Dec 4.

Human Performance Lab, Schulthess Clinic, Zurich, Switzerland. Electronic address:

Aim of this study was to investigate if knee extensor maximal voluntary contraction (MVC) torque and rate of torque development (RTD) deficits are accompanied by neuromuscular activation failure in patients with knee osteoarthritis (KOA). Nineteen patients with unilateral KOA completed gradual MVCs, from which MVC torque, voluntary activation and maximal EMG activity were recorded, and explosive MVCs, from which RTD and rate of EMG rise were recorded. For gradual MVCs, MVC torque (-28%), voluntary activation (-6%) and maximal EMG activity (-30%) were lower on the involved than on the uninvolved side (p < 0. Read More

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December 2018

Do wearable sensors add meaningful information to the Timed Up and Go test? A study on obese women.

J Electromyogr Kinesiol 2018 Dec 5;44:78-85. Epub 2018 Dec 5.

Rehabilitation Unit and Research Lab in Biomechanics and Rehabilitation, S Giuseppe Hospital, Istituto Auxologico Italiano, Piancavallo, VB, Italy.

The purpose of this study was to validate Time Up and Go test (TUG) as measured by a single Inertial Measurement Unit (IMU) placed on the lower back to that measured by a stopwatch in obese and normal weight women; in addition, the comparison of the performance of TUG test between obese and healthy women using the instrumented TUG (iTUG). Forty-four severely obese women and 14 age-matched healthy women were assessed simultaneously by IMU and stopwatch. The comparison between manual and instrumented assessment of total time duration showed no significant differences both in the healthy (8. Read More

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December 2018

Characterization of locomotor response to psychostimulants in the parthenogenetic marbled crayfish (Procambarus fallax forma virginalis): A promising model for studying the neural and molecular mechanisms of drug addiction.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

J.P. Scott Center for Neuroscience, Mind & Behavior, and Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.

Although scientific research using mammalian models has made great strides in uncovering the enigmatic neural and molecular mechanisms orchestrating the state of drug addiction, a complete understanding has thus far eluded researchers. The complexity of the task has led to the use of invertebrate model systems to complement the research of drug-induced reward in mammalian systems. Invertebrates, such as crayfish, offer excellent model systems to help reveal the underlying mechanisms of drug addiction as they retain the ancestral neural reward circuit that is evolutionarily conserved across taxa, and they possess relatively few, large neurons, laid out in an accessible, modularly organized nervous system. Read More

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December 2018

TRPC channels mediated calcium entry is required for proliferation of human airway smooth muscle cells induced by nicotine-nAChR.

Biochimie 2018 Dec 11. Epub 2018 Dec 11.

Respiratory Medicine, Hunan Provincial People's Hospital, No. 61 Jiefang Xi Road, Changsha, 410219, Hunan, PR China; Institute of Respiratory Medicine, Changsha Medical College, No. 1501 Leifeng Road, Changsha, 410219, Hunan, PR China. Electronic address:

The present study was designed to explore the role of transient receptor potential canonical 3 (TRPC3) in nicotine-induced chronic obstructive pulmonary disease (COPD) and its underlying mechanism. In this study, the expression and localization of α5 nicotinic acetylcholine receptor (α5-nAchR) in lung tissues were determined by western blotting and immunohistochemistry. The quantitative real-time PCR (qRT-PCR) analysis was performed to examine the mRNA expression levels of α5-nAchR and TRPC3 in human airway smooth muscle cells (HASMCs). Read More

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December 2018

Induced Lesion and Inhibited Ihh-PTHrP Signalling Pathway Activity in the Articular Cartilage of Rats Caused by T-2 toxin.

Toxicon 2018 Dec 11. Epub 2018 Dec 11.

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, & Harbin Medical University; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, Harbin, 150081, Heilongjiang, China. Electronic address:

This study aims to investigate the role of Ihh-PTHrP signalling pathway in the articular cartilage injury of rats caused by T-2 toxin. Sixty male Wistar rats were randomly divided into four groups: group A, normal diet; group B, normal diet plus the dissolvent (0.9% sodium chloride sterile aqueous solution containing ethanol); group C, normal diet plus low T-2 toxin (0. Read More

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December 2018

Random subspace-based ensemble modeling for near-infrared spectral diagnosis of colorectal cancer.

Anal Biochem 2018 Dec 11. Epub 2018 Dec 11.

Key Lab of Process Analysis and Control of Sichuan Universities, Yibin University, Yibin, Sichuan, 644000, China. Electronic address:

The feasibility of using near-infrared (NIR) spectroscopy coupled with classifier ensemble for improving the diagnosis of colorectal cancer was explored. A total of 157 NIR spectra from the patients were recorded and partitioned into the training set and the test set. Four algorithms, i. Read More

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December 2018

Using a coupled dynamic factor - random forest analysis (DFRFA) to reveal drivers of spatiotemporal heterogeneity in the semi-arid regions of southern Africa.

PLoS One 2018 14;13(12):e0208400. Epub 2018 Dec 14.

Department of Environmental Engineering Sciences, University of Florida, Gainesville, Florida, United States of America.

Understanding the drivers of large-scale vegetation change is critical to managing landscapes and key to predicting how projected climate and land use changes will affect regional vegetation patterns. This study aimed to improve our understanding of the role, magnitude, and spatial distribution of the key environmental and socioeconomic factors driving vegetation change in a southern African savanna. This research was conducted across the Kwando, Okavango and Zambezi catchments of southern Africa (Angola, Namibia, Botswana and Zambia) and explored vegetation cover change across the region from 2001-2010. Read More

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December 2018

Real-time Visualization of Breast Carcinoma in Pathology Specimens From Patients Receiving Fluorescent Tumor-Marking Agent Tozuleristide.

Arch Pathol Lab Med 2018 Dec 14. Epub 2018 Dec 14.

From the Departments of Pathology (Dr Dintzis) and Surgery (Ms Hales and Drs Calhoun, Javid, and Byrd), University of Washington Medical Center, Seattle; Breast Surgery Clinic (Dr Harrington), Department of Pathology (Dr Tan), and Clinical Trials (Mses Fortney and Porenta), Overlake Hospital Medical Center, Bellevue, Washington; Development (Dr Miller), Clinical Operations (Mses Ishak and Gombotz), Research (Ms Hansen and Dr Parrish-Novak), and Device Development (Dr Kittle and Mr Perry), Blaze Bioscience, Inc., Seattle, Washington; and the Department of Surgery, University of Washington, Seattle (Dr Anderson).

Context.—: Resection of breast carcinoma with adequate margins reduces the risk of local recurrence and reoperation. Tozuleristide (BLZ-100) is an investigational peptide-fluorophore agent that may aid in intraoperative tumor detection and margin assessment. Read More

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December 2018

Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography.

Arch Pathol Lab Med 2018 Dec 14. Epub 2018 Dec 14.

From the Wellman Center for Photomedicine (Drs Gardecki, Singh, and Tearney) and the Department of Pathology, Massachusetts General Hospital, Cambridge (Drs Wu and Tearney); the Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston (Dr Tearney); and the Department of Pathology, Harvard Medical School, Boston (Drs Wu and Tearney).

Context.—: The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Read More

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December 2018

[The study of patterns of development of resistance of Staphylococcus aureus to triclosan].

Klin Lab Diagn 2018 ;63(1):60-64

The Federal budget institution of science "The state scientifc center of applied microbiology and biotechnology" of the Rospotrebnadzor, 142279, Obolensk, Moscow oblast, Russia.

The article presents the results of studying molecular genetic mechanisms of development of resistance to antiseptic Triclosan in strain Staphylococcus aureus АТСС25923. The modifcations of strain S. aureus АТСС25923 (Tr1, Tr2, Tr1С и Tr2С) are obtained resistant to 64 mg/l of Triclosan and stably preserving the given characteristic under cultivation in absence of selective pressure. Read More

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January 2018

[The development of laboratory diagnostic of leprosy using polymerase chain reaction].

Klin Lab Diagn 2018 ;63(1):55-59

DNA-Technology LLC, 115478, Moscow, Russia.

The purpose of study is to develop techniques of laboratory diagnostic of leprosy on the basis of polymerase chain reaction. The techniques were worked through such as extraction of DNA from various clinical material (bioptates and scarifcate of skin, scrapes from mucous surface of nose and trophic ulcers, blood serum). The systems of oligonucleotides were constructed to 16S pRNA and probe for identifcation of Mycobacterium leprae in real-time format for amplifer DT-96 ("The DNA-Technology", Russia). Read More

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January 2018
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[The clinical laboratory characteristic of primary acute cytomegalovirus infection in non-immunocompromised adult patients].

Klin Lab Diagn 2018 ;63(1):51-54

The state budget institution of health care "The clinical center of prevention and struggle with AIDS" of the Minzdrav of the Krasnodar kraii, 350015, Krasnodar, Russia.

The purpose of study is the clinical laboratory characteristic of acquired acute cytomegalovirus infection in nonimmunocompromised adult patients. The sampling included 75 patients with acquired acute cytomegalovirus infection admitted to the specialized clinical infection hospital of the Minzdrav of the Krasnodar kraii. The verifcation of diagnosis was implemented using serological tests and polymerase chain reaction. Read More

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January 2018

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Klin Lab Diagn 2018 ;63(1):44-50

The Federal state budget educational institution of higher education "The St. Petersburg state pediatric medical university" of Minzdrav of Russia, 194100, St. Petersburg, Russia.

The purpose of study is to establish features of autoimmune reaction of children with Crohn's disease. The sampling included 62 patients aged from 2 to 17 years with diagnosis of Crohn's disease. The evaluation was carried out concerning concentration in blood serum of immunoglobulins IgA, IgM, IgG, IgЕ, antibodies to Saccharomyces cerevisiae (ASCA) classes IgA, IgG и IgЕ, antibodies to Candida albicans classes IgA, IgM, IgG и IgЕ, anti-neutrophilic cytoplasmic antibodies (ANCA) to myeloperoxidase (MPO), to proteinase 3 (PR3), anti-nuclear antibodies (ANA), antibodies to DNAds, DNAss (to double-helical and single-stranded DNA), antibodies to antigens of small and large intestines, pancreas, circulating immune complexes. Read More

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January 2018

[The serological diagnostic of toxoplasmosis in children and pregnant women using immune chemical technique by test-systems of various manufacturers].

Klin Lab Diagn 2018 ;63(1):41-44

The state budget institution of health care "The oblast children clinical hospital №1", 620149, Yekaterinburg, Russia.

The toxoplasmosis is a disease representing a potential risk for fetus. This is the reason to detect antibodies to agent of the given infection in case of any suspicion to intrauterine infection. The analysis was applied to 65 samples of blood serum of newborns, children of the frst year of life and pregnant women. Read More

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January 2018

[The synchronous detection of serological markers of main herpes viral human infections].

Klin Lab Diagn 2018 ;63(1):35-40

The closed corporation "ECOlab", Elektrogorsk, Moscow oblast, Russia.

The new original national set of reagents "Line-Blot human herpesvirus-profle" was developed to detect antibodies (IgG - set 1 and IgM - set 2) to main agents of herpesvirus infections (HSV-1, HSV-2, VZV, EBV, CMV) in the format of linear immunoblotting. The preliminary clinical trials were implemented using 319 samples of blood serum: HIV-infected patients (n=128), pregnant women (n=86) and persons undergoing treatment or diagnostic examination (n=105). In the case of every infection agent analyzes were implemented using enzyme-linked immunosorbent assay and linear immunoblotting with new set and its analogues of German manufacturer. Read More

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January 2018

[The prognostication of development of peri-apical abscess under chronic periodontitis by blood parameters and cell immunity in children].

Klin Lab Diagn 2018 ;63(1):31-34

The Federal state budget educational institution of higher education "The South-Western state university", 305040, Kursk, Russia.

The chronic periodontitis in children is frequently complicated by development of periapical abscess under inadequate conservative therapy. However, prognostic models of estimation of probability of its development are lacking. The purpose of study is to develop regression models of prognostication of periapical abscess under chronic periodontitis in children according indices of peripheral blood and systemic cellular immunity. Read More

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January 2018

[The decade hemogram of workers of phthalate industry].

Klin Lab Diagn 2018 ;63(1):28-31

The Federal budget institution of science "The Ufa research institute of occupational medicine and human ecology" of Minzdrav of Russia, 450106, Ufa, Russia.

The article presents decade dynamics of hemogram of workers started their labor activity in factories of terephthalic acid, purifed terephthalic acid and polyethylene terephthalate. The study established a hemodynamics depended on career pattern, characterizing hematologic shifts i.e. Read More

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January 2018

[The role of fraction analysis of ferritin in diagnostic of secondary hemophagocyte syndrome].

Klin Lab Diagn 2018 ;63(1):21-27

The Federal state budget educational institution of higher education "The Pavlov First Saint Petersburg State Medical University" of Minzdrav of Russia, 197022, St. Petersburg, Russia.

The secondary hemophagocytic syndrome is a life-threatening condition characterized by non-specifc manifestations: systemic inflammatory reaction, cytopenia, liver affection, high content of ferritin in blood serum. One of manifestations of secondary hemophagocytic syndrome is decreasing of level of glycated ferritin in blood serum expressed in percentage of total level. The detection of glycated ferritin can be applied for a differentiated diagnosis with cli9nically similar conditions, including septic process. Read More

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January 2018

[The comparison of two chemiluminescent models for assessing anti-oxidative activity of blood serum of patients with liver pathology].

Klin Lab Diagn 2018 ;63(1):16-21

The Federal state budget scientifc institution "the Russian cardiologic R&D production complex" of Minzdrav of Russia, 121552, Moscow, Russia.

The comparative assessment was carried out concerning anti-oxidation activity of blood serum of patients with liver pathology using two chemiluminescent techniques with different models of free radical oxidation: «Hb-Н2О2-luminol» и «ABAP-luminol». The reliable but low correlation of results was established (r=0,798) related mainly to difference in mechanisms of initiation of free radicals and effect of blood serum on initiation process. This effect is stronger manifested in model «Hb-Н2О2-luminol». Read More

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January 2018

[The becoming of reactions of lipolysis in phylogenesis. The palmitic and oleic triglycerides as substrates. Insulin, condition of normolipemia and formation of hyper lipoproteinemia type IIb, IV and V].

Klin Lab Diagn 2018 ;63(1):4-15

The Federal state budget scientifc institution "The research institute of general pathology and pathophysiology" of the Russian academy of sciences, 125315, Moscow, Russia.

According to phylogenetic theory of general pathology, when living in ocean all were carnivorous (piscivorous) fatty acids transferring to cells in form of non-polar triglycerides nitially began apoB-48 chylomicrons, continued lipoproteins of very low and low density and fnalized its apoB-100 endocytosis. The fatty acids are transferred by chylomicrons + lipoproteins of very low density + lipoproteins of low density and non-polar triglycerides are hydrolyzed by hepatic glycerolhydrogenase and co-enzyme apoC-III; according WHO classifcation, hyperlipoproteinemia corresponds to type V. On land, in herbivorous who are not yet synthesized insulin, apoB-48 and chylomicrons left process of non-polar triglycerides transferring. Read More

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January 2018

Identification of a Novel Gene Mutation in a Chinese Pedigree with X-linked Thrombocytopenia.

Clin Lab 2018 Oct;64(11)

Background: X-linked thrombocytopenia (XLT) is a milder form of Wiskott-Aldrich syndrome (WAS), characterized predominantly by thrombocytopenia with small-sized platelets. Mutations in the WAS gene are responsible for the disease. We herein detected a new mutation in the WAS gene responsible for XLT in a 3-generation Chinese pedigree. Read More

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October 2018

Thiol-Disulfide Homeostasis in Cerebral Venous Sinus Thrombosis.

Clin Lab 2018 Oct;64(11)

Background: The objective of this study is to examine thiol-disulfide homeostasis in patients with cerebral venous sinus thrombosis.

Methods: Fifty-three patients diagnosed with cerebral venous sinus thrombosis and 80 healthy volunteers were included in the study. The native thiol and total thiol concentrations were measured with the newly developed automated method. Read More

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October 2018

Effect of lncRNA BNC2-AS1 on the Proliferation, Migration and Invasion of Gastric Cancer Cells.

Clin Lab 2018 Oct;64(11)

Background: Gastric cancer is one of the most common cancers and is the second leading cause of cancer mortality worldwide. The present study aimed to investigate the potential biological effect of long non-coding RNA (lncRNA) BNC2-AS1 on the proliferation, migration, and invasion of cervical cancer cells. Methods: BNC2-AS1 small interfering RNA (siRNA) was transfected into SGC7901 and BGC823 gastric cancer cell lines, with negative siRNA serving as a control. Read More

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October 2018

Detection and Evaluation of Escherichia coli O157:H7 and Shiga-toxin Genes stx1, stx2 in Cattle Meat Samples.

Clin Lab 2018 Oct;64(11)

Background: Screening of transmission routes and routine control of the food for foodborne-pathogens are vital in terms of public health. In this study, we aimed to investigate and evaluate the presence of E. coli O157:H7 strains and toxins in the cattle meat samples collected from different markets and butchers. Read More

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October 2018

Association Between the Polymorphism in miR-605 and Cancer Susceptibility: a PRISMA-Compliant Meta-Analysis.

Clin Lab 2018 Oct;64(11)

Background: MicroRNAs (miRNAs) play important roles in cancer development. miR-605 was reported in several studies and showed potential as a prognostic biomarker. However, the association between miR-605 and the risk of cancer remained controversial in previous studies. Read More

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October 2018

A Case of Unicentric Castleman Disease and Langerhans Cell Histiocytosis: Two Entities in One Lymph Node.

Clin Lab 2018 Oct;64(11)

Background: Castleman disease (CD) is a lymphoproliferative disorder and Langerhans cell histiocytosis (LCH) is a clonal disease of the monocyte-macrophage system. The authors describe a rare case of CD coexistent with LCH at diagnosis in one lymph node. Methods: Hematologic investigation and intrapulmonary mass biopsy were performed. Read More

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October 2018
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Estimated Total Albumin in Fresh Urine Samples Based on Correlation Between the Roche Immunoturbidimetric and an In-House HPLC Method.

Clin Lab 2018 Oct;64(11)

Background: Many studies have reported higher values of urinary albumin measured by high performance liquid chromatography (HPLC) in comparison with immunochemical methods. The aims of our study were the implementation of the HPLC method for albuminuria, testing the hypothesis about coeluting proteins, comparison of albuminuria assessed by HPLC and immunoturbidimetric (IT) methods in diabetic and non-diabetic patient samples. Methods: We compared albuminuria assessed by HPLC with albuminuria assessed by the IT method in fresh urine samples of 636 diabetics and 456 non-diabetics. Read More

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October 2018

Clinical Laboratory Reference Intervals in Ethiopia: Current Status and Future Considerations: Review.

Clin Lab 2018 Oct;64(11)

Background: Clinical laboratory reference intervals are derived from a sample of selected healthy population and they are used for disease diagnosis, management, and monitoring. International guidelines recommended that laboratories and manufacturers are supposed to establish their own RIs for a certain group of population. Therefore, the aim of this narrative review is to summarize the current status and to show future directions regarding reference intervals of clinical laboratory parameters among Ethiopian population. Read More

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October 2018

Mean Platelet Volume in Patients with Acute Ischemic Stroke with Nonvalvular Atrial Fibrillation.

Clin Lab 2018 Oct;64(11)

Background: Platelets play an important role in the pathogenesis of vascular disease, and the size of the platelets can determine their reactivity. Large platelets secrete more prothrombotic factors and aggregate more quickly. In this study, we aimed to investigate mean platelet volume (MPV) levels, which are considered to be an indication of the increase in platelet function in previous studies, in cases of acute ischemic stroke (AIS) with nonvalvular atrial fibrillation (NVAF). Read More

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October 2018

Long Non-Coding RNA TUG1 as a Potential Novel Biomarker for Predicting the Clinical Outcome of Cancer Patients: a Meta-Analysis.

Clin Lab 2018 Oct;64(11)

Background: Emerging evidence suggests that long non-coding RNAs (lncRNAs) can be used as potential biomarkers for a wide range of cancers. Herein, the prognostic value of lncRNA taurine upregulated gene (TUG1) was analyzed using meta-analysis in different kinds of cancers. Methods: Databases including Cochrane Library, PubMed, and Chinese National Knowledge Infrastructure were searched for epidemiological studies up to March 2018. Read More

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October 2018

Changes in Prealbumin and Body Mass Index Associated with T Lymphocyte Subsets and Nutritional Status in Chronic Hepatitis B and HBV-Cirrhosis Patients.

Clin Lab 2018 Oct;64(11)

Background: Patient immune response is one of the main factors influencing hepatitis virus (HBV) eradication or chronicity. Our study aimed to investigate the relationship between the nutritional status and immune function, and to provide the appropriate clinical diagnosis data for treatment of patients with chronic hepatitis B virus (CHB) and cirrhosis. Methods: T lymphocyte subsets were tested using flow cytometry in 100 patients (48 with CHB, 52 with cirrhosis) and 26 healthy individuals. Read More

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October 2018

Assessment of Serum Vitamin D and Irisin Levels in Obese Patients.

Clin Lab 2018 Oct;64(11)

Background: 25-hydroxyvitamin D and irisin have been found to be involved in the pathogenesis of obesity. The aim of the study is to assess the serum levels of 25-hydroxyvitamin D and irisin in obese patients and to determine the association of 25-hydroxyvitamin D and irisin levels with anthropometric parameters. Methods: The study was carried out on 300 obese patients in addition to 156 healthy age and gender matched subjects as a control group. Read More

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October 2018

Does Adenovirus and Coxsackie B Virus Infection Play a Role in Tracheobronchopathia Osteochondroplastica (TO).

Clin Lab 2018 Oct;64(11)

Background: Tracheobronchopathia osteochondroplastica (TO) is a rare benign disease. We report a case of TO. Methods: Chest CT scan and bronchoscope with biopsy was performed for diagnosis and blood tests explored for the latent etiology. Read More

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October 2018

Serum Cryptococcal Antigen Confirmed Pulmonary Cryptococcosis in an Immune-competent Adult Firstly Misdiagnosed of Tuberculosis from a Lung Biopsy: a Case Report and Literature Review.

Clin Lab 2018 Oct;64(11)

Background: Cryptococcal pneumonia is an uncommon lesion in immune-competent adults. Histological evidence of Cryptococcus neoformans is a gold criterion for diagnosis. Here we report a case firstly misdiagnosed as tuberculosis from a lung biopsy. Read More

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October 2018

LBH mRNA Expression and Polymorphisms in Patients with Rheumatoid Arthritis.

Clin Lab 2018 Oct;64(11)

Background: This study was performed to determine the mRNA expression levels of limb-bud and heart (LBH) in peripheral blood mononuclear cells (PBMCs) from patients with rheumatoid arthritis (RA), and to assess the associations of LBH rs7579944 and rs906868 polymorphisms with RA in a Chinese population. Methods: Real-time transcription-polymerase chain reaction analysis was used to determine the LBH mRNA expression in PBMCs from 53 patients with RA and 58 healthy controls, and LBH rs7579944 and rs906868 polymorphisms were genotyped in 328 RA patients and 449 healthy controls. Results: The LBH mRNA expression levels were significantly decreased in RA patients compared with healthy controls (p = 0. Read More

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October 2018

Live Confocal Visualization of FXIII Activity.

Clin Lab 2018 Oct;64(11)

In addition to its important functions in angiogenesis, wound healing, bone biology, immunology, pregnancy, and adipogenesis, transglutaminase factor XIII is an outstanding determinant of clot characteristics. Factor XIII mediates clot stability by covalent cross-linking of fibrin-fibrils and inhibition of fibrinolysis. For decades it was assumed that factor XIII mediates the formation of a 3-dimensional net structure of the clot. Read More

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October 2018

The Generation of Hematopoietic Progenitor Cells from Endothelial Cells by Silymarin.

Clin Lab 2018 Oct;64(11)

Background: The generation of hematopoietic cells from endothelial cells may determine a novel approach for the production of blood cells. Regenerative functions of Silymarin, a mixture of polyphenolic flavonoids derived from milk thistle, have previously been reported. The purpose of this study was to investigate the direct effect of Silymarin on conversion of endothelial cells to hematopoietic cells. Read More

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October 2018

Evaluation of the Elecsys Syphilis Assay as a Laboratory Screening Test for Syphilis.

Clin Lab 2018 Oct;64(11)

Background: The sexually transmitted infection (STI) syphilis remains a public health problem globally. The serological detection of specific antibodies to Treponema pallidum is particularly important in the diagnosis of syphilis. The purpose of this study was to evaluate the newly developed Elecsys Syphilis assay and compare it with the local market well-established ARCHITECT Syphilis TP assay. Read More

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October 2018

Biomaterial-induced multinucleated giant cells express proinflammatory signaling molecules: A histological study in humans.

J Biomed Mater Res A 2018 Dec 13. Epub 2018 Dec 13.

Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab, University Hospital Frankfurt Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

The biomaterials physicochemical characteristics influence their cellular reaction, degradation and regenerative capacities. Macrophages and multinucleated giant cells (MNGCs) are observed in the augmentation area of biomaterials. This study, for the first time, evaluated the polarization pattern of macrophages and MNGCs in response to two different bone substitute materials (synthetic bone substitute material (SBSM) = NanoBone® vs. Read More

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December 2018
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