472,986 results match your criteria La Revue de medecine interne / fondee ... par la Societe nationale francaise de medecine interne[Journal]


Altered sleep architecture, rapid eye movement (REM) sleep, and neural oscillation in a mouse model of human chromosome 16p11.2 microdeletion.

Sleep 2018 Dec 12. Epub 2018 Dec 12.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA.

Sleep abnormalities are common among children with neurodevelopmental disorders. The human chr16p11.2 microdeletion is associated with a range of neurological and neurobehavioral abnormalities. Read More

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December 2018
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Reconsidering the Latent Structure of Negative Symptoms in Schizophrenia: A Review of Evidence Supporting the 5 Consensus Domains.

Schizophr Bull 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, Reno School of Medicine, University of Nevada, Reno, NV.

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December 2018

Evidence that a catalytic glutamate and an 'Arginine Toggle' act in concert to mediate ATP hydrolysis and mechanochemical coupling in a viral DNA packaging motor.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.

ASCE ATPases include ring-translocases such as cellular helicases and viral DNA packaging motors (terminases). These motors have conserved Walker A and B motifs that bind Mg2+-ATP and a catalytic carboxylate that activates water for hydrolysis. Here we demonstrate that Glu179 serves as the catalytic carboxylate in bacteriophage λ terminase and probe its mechanistic role. Read More

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December 2018

Prognostic value of left atrial strain in predicting cardiovascular morbidity and mortality in the general population.

Eur Heart J Cardiovasc Imaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Denmark.

Aims: Left atrial (LA) enlargement predicts cardiovascular risk. The prognostic value of left atrial peak reservoir strain (LA RS) by two-dimensional speckle tracking in the general population is currently unknown. This study sought to determine the prognostic value of LA RS in the general population. Read More

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December 2018

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More

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December 2018

Mucosal healing and bacterial composition in response to enteral nutrition versus steroid based induction therapy - a randomized prospective clinical trial in children with Crohn's disease.

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Hôpital Necker Enfants Malades Université Sorbonne Paris Cité, Paris, APHP.

Exclusive Enteral Nutrition (EEN) is as efficacious as corticosteroids (CS) to induce remission in Crohn's disease (CD), without their adverse effects. EEN seems to be more efficient than steroids to induce mucosal healing, but the underlying molecular mechanisms are only sparsely understood. We aimed in the present work to study the anti-inflammatory effects of EEN with Modulen IBD® versus CS in active pediatric CD and to assess its modulatory effects on the intestinal microbiota as compared to steroids. Read More

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December 2018

Coherent optical and acoustic phonons generated at lattice-matched GaP/Si(001) heterointerfaces.

J Phys Condens Matter 2018 Dec 12. Epub 2018 Dec 12.

Department of Physics, University of Florida, P.O. Box 118440, Gainesville, Florida, 32611, UNITED STATES.

Thin GaP films can be grown on an exact Si(001) substrate with nearly perfect lattice match. We perform all-optical pump-probe measurements to investigate the ultrafast electron-phonon coupling at the buried interface of GaP/Si. Above-bandgap excitation with a femtosecond laser pulse can induce coherent longitudinal optical (LO) phonons both in the GaP opverlayer and in the Si substrate. Read More

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December 2018

Effect of the anchoring strength on the phase behaviour of discotic liquid crystals under face-on confinement.

J Phys Condens Matter 2018 Dec 12. Epub 2018 Dec 12.

Universidad Nacional Autonoma de Mexico Instituto de Investigaciones en Materiales, Mexico D.F., Coyoacan, MEXICO.

In this study we have performed molecular dynamics simulations to study a Gay-Berne discotic fluid confined in a slab geometry for a fixed confinement length. Four different anchoring strengths with a homeotropic (face-on) configuration were studied. We found that changing the anchoring strength changes the normal component of the stress tensor, which in turn changes de density of the system's bulk. Read More

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December 2018

Inferring symmetric and asymmetric interactions between animals and groups from positional data.

PLoS One 2018 12;13(12):e0208202. Epub 2018 Dec 12.

Department of Mathematics and Statistics, University of Western Australia, Nedlands, Perth, WA, Australia.

Interactions between domestic and wild species has become a global problem of growing interest. Global Position Systems (GPS) allow collection of vast records of time series of animal spatial movement, but there is need for developing analytical methods to efficiently use this information to unravel species interactions. This study assesses different methods to infer interactions and their symmetry between individual animals, social groups or species. Read More

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December 2018

Can patients be trained to expect shared decision making in clinical consultations? Feasibility study of a public library program to raise patient awareness.

PLoS One 2018 12;13(12):e0208449. Epub 2018 Dec 12.

Tier 1 Canada Research Chair in Shared Decision Making and Knowledge Translation, Université Laval, Quebec City (QC, Canada).

Introduction: Shared decision making (SDM) is a process whereby decisions are made together by patients and/or families and clinicians. Nevertheless, few patients are aware of its proven benefits. This study investigated the feasibility, acceptability and impact of an intervention to raise public awareness of SDM in public libraries. Read More

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December 2018

Assessing the potential of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications.

PLoS One 2018 12;13(12):e0208908. Epub 2018 Dec 12.

Department of Electronic Engineering, Universitat Rovira i Virgili, Tarragona, Spain.

Mass spectrometry imaging (MSI) is a molecular imaging technique that maps the distribution of molecules in biological tissues with high spatial resolution. The most widely used MSI modality is matrix-assisted laser desorption/ionization (MALDI), mainly due to the large variety of analyte classes amenable for MALDI analysis. However, the organic matrices used in classical MALDI may impact the quality of the molecular images due to limited lateral resolution and strong background noise in the low mass range, hindering its use in metabolomics. Read More

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December 2018

Regional paleoclimates and local consequences: Integrating GIS analysis of diachronic settlement patterns and process-based agroecosystem modeling of potential agricultural productivity in Provence (France).

PLoS One 2018 12;13(12):e0207622. Epub 2018 Dec 12.

Schools of Sustainability and Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States of America.

Holocene climate variability in the Mediterranean Basin is often cited as a potential driver of societal change, but the mechanisms of this putative influence are generally little explored. In this paper we integrate two tools-agro-ecosystem modeling of potential agricultural yields and spatial analysis of archaeological settlement pattern data-in order to examine the human consequences of past climatic changes. Focusing on a case study in Provence (France), we adapt an agro-ecosystem model to the modeling of potential agricultural productivity during the Holocene. Read More

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December 2018
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[Primary gastric choriocarcinoma: case report].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):297-300

Hospital Guillermo Kaelin de la Fuente. Lima, Perú; Universidad San Ignacio de Loyola, Lima, Perú.

Primary gastric choriocarcinoma (PGC) is an extremely rare and highly invasive tumor with rapid hematogenous spread. We present the case of a 57-year-old female patient who started with hematemesis and progressive episodes of melena, weight loss and epigastralgia. It is derived from the National Institute of Neoplastic Diseases where gastroscopy and biopsy are performed. Read More

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December 2018
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[Anti-transglutaminase antibody in adults with celiac disease and their relation to the presence and duration of gluten-free diet].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):228-233

Departamento de Inmunología, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción. San Lorenzo, Paraguay.

IgA anti-transglutaminase 2 (tTG2) antibody is a relevant marker in celiac disease. The utility of IgA anti-tTG2 determination is well established for the diagnosis, however their use in the follow-up of patients with gluten free diet (GFD) it is not fully established.

Objective: To determine IgA anti-tTG2 antibody levels in adult Paraguayan celiac disease patients and its relation to the presence and duration of the GFD. Read More

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December 2018

[Liver transplant: a second chance].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):227

Revista de Gastroenterología del Perú. Lima, Perú; Hospital Central de la Fuerza Aérea del Perú. Lima, Perú.

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December 2018

Multicenter Validation of the Emotional State Instrument for Dialysis Patients.

Nurs Res 2019 Jan/Feb;68(1):39-47

Rocío Rodríguez-Rey, PhD, is Associate Professor, Department of Psychology, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Spain. Helena García-Llana, PhD, is Psychology Associate Researcher, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid, Spain. María Paz Ruiz-Álvarez, MP, is Registered Nurse, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid, Spain. Alicia Gómez-Gómez, MP, is Registered Nurse, Department of Nephrology, Henares Hospital, Madrid, Spain. Gloria del Peso, PhD, is Nephrology Consultant, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid Spain. Rafael Selgas, PhD, is Department Head, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid, Spain.

Background: The Emotional State Instrument for Dialysis Patients (ES-D) is a brief semistructured questionnaire to assess emotional distress in patients undergoing dialysis. It was designed to be administered by a healthcare provider. A previous study showed preliminary indicators of its content and face validity. Read More

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December 2018
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Sacubitril/valsartan in daily clinical practice: data from a prospective registry.

J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Servicio de Cardiología. Hospital Universitario Gregorio Marañón. CIBERCV. Madrid, Spain.

Sacubitril/valsartan (SV) is a new therapy in heart failure with reduced ejection fraction. Our aim was to determine the efficacy and safety of this drug daily clinical practice.We performed a multicenter registry in 10 hospitals. Read More

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December 2018
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Design and rationale of the Edoxaban Treatment in routiNe clinical prActice for patients with Atrial Fibrillation in Europe (ETNA-AF-Europe) study.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Institute of Cardiovascular Sciences, University of Birmingham, SWBH and UHB NHS Trusts, Birmingham, UK.

Aim: Edoxaban, a nonvitamin K antagonist oral anticoagulant, is an oral factor Xa inhibitor approved for the prevention of stroke and systemic embolism in adult patients with atrial fibrillation and for the treatment and secondary prevention in adult patients with venous thromboembolism (VTE). This study details the design of the Edoxaban Treatment in routiNe clinical prActice for patients with Atrial Fibrillation in Europe (ETNA-AF-Europe) study - a postauthorization observational study, which is part of the postapproval plan for edoxaban agreed with the European Medicines Agency.

Methods: The ETNA-AF-Europe study (Clinicaltrials. Read More

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December 2018
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Standards of Care for Hypoparathyroidism in Adults.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

B Clarke, Medicine, Mayo Clinic School of Medicine, Rochester, MN, USA, Rochester, United States.

Purpose: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included. Read More

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December 2018

Co-infection organises epidemiological networks of viruses and hosts and reveals hubs of transmission.

Phytopathology 2018 Dec 12. Epub 2018 Dec 12.

Universidad Politecnica de Madrid, Centro de Biotecnología y Genómica de Plantas, Madrid, Madrid, Spain ;

Multiple virus infections affect the competence of host plants to transmit disease. The effects of co-infection on transmission are expected to produce ecologically complex pathogen and host-pathogen interactions. However, the prediction of disease risk will rely on untangling non-random from random patterns of infection to identify underlying processes that drive these interactions. Read More

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December 2018

Two Series of Microporous Lanthanide-Organic Frameworks with Different Secondary Building Units and Exposed Lewis Base Active Sites: Sensing, Dye Adsorption, and Magnetic Properties.

Inorg Chem 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry & Materials Science , Northwest University , Xi'an 710127 , Shaanxi , P. R. China.

Two series of new lanthanide complexes, {[Ln(L)(HO)]·DMA·4HO} (1-Ln, Ln = Tb, Gd, and Dy) and {[La(L)]·4HO} (2-La), were prepared successfully by Ln ions and a N-heterocyclic dicarboxylic (2-pyrimidin-5-yl)terephthalic acid (HL) ligand. The four complexes are three-dimensional (3D) microporous frameworks with different secondary building units (SBUs) and exposed Lewis base active sites. Topology analyses reveal that 1-Ln are the binodal (3,8)-connected tfz-d (4)(4·6·8) nets and 2-La is a binodal (2,12)-connected (4)(4·8·12) net. Read More

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December 2018

Enhancement of magnetic relaxation properties with 3d diamagnetic cations in [ZnLn] and [NiLn], Ln = Kramers lanthanides.

Dalton Trans 2018 Dec 12. Epub 2018 Dec 12.

Departament de Química Inorgànica i Orgànica, Secció Inorgànica and Institute of Nanoscience (IN2UB) and Nanotechnology, Universitat de Barcelona, Marti i Franques 1-11, Barcelona-08028, Spain.

Employing the chiral bi-compartmental Schiff-base ligand H2L obtained from the condensation of (RR) or (SS)-1,2-diphenyl-ethylenediamine and o-vanillin, we report the structural characterization of the discrete dinuclear pairs of enantiomers [NiIIEuIII] 1RR, 1SS and [ZnIIEuIII] 2RR, 2SS and the magnetic properties for the series of complexes [NiIILnIII], Ln = Ce, 3RR; Nd, 4RR; Dy, 5RR; Er, 6RR, Yb, 7SS and [ZnIILnIII], Ln = Ce, 8RR; Nd, 9RR; Dy, 10SS; Er, 11SS and Yb, 12RR in which MII is diamagnetic and LnIII is a Kramers lanthanide. Single crystal X-ray diffraction shows that relevant changes in the [ZnIILnIII] structures are produced after a period in open air (2RRb, 2RRc), evidencing that the lability of the ligands bonded to ZnII can modify the structures that will be correlated to the experimental measurements. The dynamic magnetic measurements showed that the [NiIILnIII] and [ZnIILnIII] derivatives exhibit different behaviors in the relaxation of magnetization especially for oblate and prolate LnIII cations. Read More

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December 2018

Physical, Anthropometric, and Athletic Movement Qualities Discriminate Development Level in a Rugby League Talent Pathway.

J Strength Cond Res 2018 Nov;32(11):3169-3176

Discipline of Sport and Exercise Science, James Cook University, Queensland, Australia.

Pearce, LA, Sinclair, WH, Leicht, AS, and Woods, CT. Physical, anthropometric, and athletic movement qualities discriminate development level in a rugby league talent pathway. J Strength Cond Res 32(11): 3169-3176, 2018-This study compared the physical, anthropometric, and athletic movement qualities of talent-identified rugby league (RL) players within a development pathway. Read More

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November 2018

Removal of Escherichia coli from well water using continuous laminar flow in a channel system containing PPy/Cu modified electrodes.

J Water Health 2018 Dec;16(6):921-929

Instituto de Ingeniería Electroquímica y Corrosión (INIEC), Departamento de Ingeniería Química, Universidad Nacional del Sur - CONICET, Av. Alem 1253, (8000) Bahía Blanca, Argentina E-mail:

Polypyrrole (PPy) films modified with copper species were used for disinfection of well water contaminated with Escherichia coli (E. coli). For that purpose a laboratory-scale continuous flow system with a parallel plate flow chamber configuration was implemented operating under laminar flow. Read More

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December 2018

Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process.

Physiol Rev 2019 Jan;99(1):853-892

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , La Jolla, California ; and Washington University School of Medicine, St. Louis, Missouri.

The central functions fulfilled by mitochondria as both energy generators essential for tissue homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight control over the quality and quantity of these ubiquitous endosymbiotic organelles. Mitophagy, the targeted engulfment and destruction of mitochondria by the cellular autophagy apparatus, has conventionally been considered as the mechanism primarily responsible for mitochondrial quality control. However, our understanding of how, why, and under what specific conditions mitophagy is activated has grown tremendously over the past decade. Read More

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January 2019

Lanthanide-Based Coordination Polymers With 1,4-Carboxyphenylboronic Ligand: Multiemissive Compounds for Multisensitive Luminescent Thermometric Probes.

Inorg Chem 2018 Dec 12. Epub 2018 Dec 12.

Univ Rennes, INSA Rennes, CNRS, UMR 6226 "Institut des Sciences Chimiques de Rennes" , F-35000 Rennes , France.

Reactions in water of lanthanide chlorides with the sodium salt of 1,4-carboxyphenylboronic acid lead to two series of isostructural compounds with respective general chemical formulas [Ln(cpb)(HO)] for Ln = La or Ce and [Ln(cpbOH)(HO)·(cpb)] for Ln = Pr-Lu (except Pm) plus Y. Heterolanthanide coordination polymers that are isostructural to the second series have been synthesized, and their photophysical properties have been studied. This study evidences that it is possible to design multiemissive lanthanide-based coordination polymers that could find their application as multigauge luminescent thermometric probes. Read More

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December 2018

Study of the Coordination Modes of Hybrid NNCp Cyclopentadienyl/Scorpionate Ligands in Ir Compounds.

Inorg Chem 2018 Dec 12. Epub 2018 Dec 12.

Departamento de Química Inorgánica, Orgánica y Bioquímica, and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Facultad de Ciencias y Tecnologías Químicas , Universidad de Castilla-La Mancha , 13071 Ciudad Real , Spain.

A new coordination mode for the hybrid scorpionate/cyclopentadienyl ligand bpzcp, [bpzcp = 2,2-bis(3,5-dimethylpyrazol-1-yl)-1,1-diphenylethylcyclopentadienyl] is observed in iridium complexes. The reaction of the lithium precursor, [Li(bpzcp)(THF)], with a range of [IrCl(diene)] compounds leads to an unprecedented binding mode of the hybrid scorpionate/cyclopentadienyl ligand as η-Cp-coordinated and the formation of Ir(I) derivatives [Ir(η-Cp-bpzcp)(η-cod)] (1), [Ir(η-Cp-bpzcp){η-CH═C(Me)C(Me)═CH}] (2), [Ir(η-Cp-bpzcp)(η-coe)] (3), and [Ir(η-Cp-bpzcp)(η-CH═CH)] (4). The Ir(I) complex 4 reacts with CO or bromine to afford the compound [Ir(η-Cp-bpzcp)(CO)] (5) and the 18e Ir(III) complex [Ir(κ-N-η-Cp-bpzcpBr)Br] (6), respectively. Read More

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December 2018

Structural and Luminescence Properties of Anthracene- and Biphenyl-Based Lanthanide Bisphosphonate Ester Coordination Polymers.

Inorg Chem 2018 Dec 12. Epub 2018 Dec 12.

Institute of Chemistry and Center for Interdisciplinary Nanostructure Science and Technology , University of Kassel , Heinrich-Plett-Strasse 40 , 34132 Kassel , Germany.

Coordinative networks containing lanthanide ions attached via phosphonate ester functionalities provide remarkable luminescence properties. On the basis of ditopic phosphonic ester ligands with biphenylene and 9,10-anthracenylene bridges, a series of compounds with formal composition {[M(NO)]L} or {[M(NO)](L1)} (L = CHOP; L1 = CHOP) with M = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and Y have been synthesized, structurally characterized, and the luminescence behavior was explored in the visible and NIR spectral regions, where applicable. In contrast to closely related networks based on biphenyl bisphosphonate esters from previous work, no evidence for ligand-to-metal energy transfer could be observed, despite strong near-infrared emission in some cases. Read More

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December 2018

Cross-cultural adaptation and validation of Pamela Reed's Self-Transcendence Scale for the Spanish context.

Rev Lat Am Enfermagem 2018 Dec 10;26:e3058. Epub 2018 Dec 10.

Universitat Jaume I, Facultad de Ciencias de la Salud, Castellón, Comunidad Valenciana, Spain.

Objectives: the current study aimed to adapt the Self-Transcendence Scale (STS) to the Spanish context and analyse its psychometric properties.

Method: the STS was administered to a general Spanish population of adults (i.e. Read More

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December 2018

Molecular typing reveals the co-existence of two transmission cycles of American cutaneous leishmaniasis in the Andean Region of Venezuela with Lutzomyia migonei as the vector.

Mem Inst Oswaldo Cruz 2018 Dec 6;113(12):e180323. Epub 2018 Dec 6.

Universidad de Carabobo, Facultad de Ciencias de la Salud, Centro Nacional de Referencia de Flebotomos y otros Vectores, Instituto de Investigaciones Biomédicas Dr Francisco J Triana-Alonso, Maracay, Venezuela.

BACKGROUND The transmission routes for American cutaneous leishmaniasis (ACL) are in flux, so studies examining its transmission in humans, mammalian hosts, and sand fly vectors are urgently needed. OBJECTIVES The aim of this work was understand the epidemiological cycles of Leishmania spp., which causes ACL in the Andean Region of Venezuela, by identifying the Leishmania and the sand fly species involved in human and dog infections. Read More

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December 2018

Brazilian National School Food Program as a promoter of local, healthy and sustainable food systems: evaluating the financial implementation.

Cien Saude Colet 2018 Dec;23(12):4189-4197

Programa de Pós-Graduação em Nutrição, Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina. Florianópolis SC Brasil.

This study aimed to analyze the financial investment used for the procurement of food for the Brazilian National School Food Program (PNAE) in a city in the South of Brazil. The bidding process, the public calls and accountability reports of the PNAE were analyzed in the following variables: I) municipal financial complementation values; II) percentage of resources used to purchase foods from Family Farmer (FF), and Recommended, Restricted, Prohibited and others foods. The comparison of proportions was employed as a test to identify differences between investments. Read More

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December 2018

Ganodermanontriol inhibits expression of special AT rich sequence binding protein 1 gene in human hepatocellular carcinoma.

J Cancer Res Ther 2018 Dec;14(Supplement):S964-S968

Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan, Guangdong 523808, China, Dongguan.

Context: The metastasis of liver cancer is a major cause of clinical treatment failure, restrain, and control the cancer metastasis is the major strategy of the treatment and prevention of the disease. Special AT-rich sequence-binding protein 1 (SATB1) gene was overexpressed in many malignant tumors and considered as a potential target of anticancer drug. This study investigated the mechanism how ganodermanontriol effect the expression of SATB1 and thus inhibits the growth and metastasis in hepatocellular carcinoma (HCC). Read More

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December 2018

Essential oils and functional herbs for healthy aging.

Neural Regen Res 2019 Mar;14(3):441-445

School of Pharmacy and Applied Science, La Trobe Institute for Molecular Sciences, La Trobe University, Bendigo, Australia.

As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in the brain and cholinergic deficits leads to cognitive dysfunction and decline. Read More

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March 2019
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Multitarget therapeutic strategies for Alzheimer's disease.

Neural Regen Res 2019 Mar;14(3):437-440

Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; Department of Chemistry, University of Iowa, Iowa City, IA, USA.

Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to design multitarget-directed ligands to address the complementary pathways involved in these diseases. The major enzyme targets for development of therapeutics for Alzheimer's disease are cholinesterase and β-secretase enzymes. Read More

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Do immature and mature sibling oocytes recovered from stimulated cycles have the same reproductive potential?

Reprod Biomed Online 2018 Dec 6;37(6):667-676. Epub 2018 Oct 6.

IVF Laboratory, IVIRMA-Valencia, Valencia 46015, Spain; IVI Foundation, INCLIVA, Valencia 46026, Spain. Electronic address:

Research Question: How can laboratory and clinical outcomes of spontaneously, early maturing germinal-vesicle oocytes and sibling in-vivo-matured (metaphase II [MII]) oocytes be quantified and compared?

Design: A prospective, non-randomized intra-cohort study of oocytes from women aged 38 years or younger, with six or fewer MII oocytes and four or more germinal vesicles retrieved. No indication was identified for genetic tests or oocyte or embryo cryopreservation. The study was carried out at IVIRMA-Valencia. Read More

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December 2018

Transoesophageal echocardiography current practice in France: A multicentre study.

Arch Cardiovasc Dis 2018 Dec 4;111(12):730-738. Epub 2018 Jul 4.

Department of cardiology, SOS Endocardites, Henri-Mondor Hospital, 94010 Creteil, France.

Background: Few data are available on the application of transoesophageal echocardiography (TOE) recommendations in daily practice.

Aims: To evaluate TOE practice based on echocardiography societies' guidelines, and to determine complication rates and factors associated with patient feelings.

Methods: Between April and June 2017, we prospectively included all consecutive patients referred to 14 French hospitals for a transoesophageal echocardiogram (TOE). Read More

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December 2018

Oxygen regulation of aquaporin-4 in human placenta.

Reprod Biomed Online 2018 Nov 6;37(5):601-612. Epub 2018 Oct 6.

Laboratorio de Biología de la Reproducción, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO)- CONICET- Facultad de Medicina, Universidad de Buenos Aires. Paraguay 2155 (1121) Buenos Aires, Argentina; Cátedra de Biología Celular y Molecular, Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires. Junín 956 (1113) Buenos Aires, Argentina. Electronic address:

Research Question: We recently reported that blocking of placental aquaporins (AQP) abrogates the apoptotic response of the trophoblast. As trophoblast apoptosis is exacerbated in pre-eclampsia, we hypothesized that changes in AQP in these placentae may trigger programmed cell death. We analysed AQP4 expression in pre-eclamptic placentae and its regulation by oxygen tension. Read More

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November 2018

[68Ga]-Dota Peptide Pet/Ct In Neuroendocrine Tumors: Main Clinical Applications.

Curr Radiopharm 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, S. Andrea Hospital, La Spezia. Italy.

Objective: Neuroendocrine neoplasms (NENs) are generally defined as rare and heterogeneous tumors. The gastrointestinal system is the most frequent site of NENs localization, however they can be found in other anatomical regions, such as pancreas, lungs, ovaries, thyroid, pituitary, and adrenal glands. Neuroendocrine neoplasms have significant clinical manifestations depending on the production of active peptide. Read More

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December 2018

Detection of SSA and SSB Antibodies Associated with Primary Sjögren's Syndrome Using Enzyme-Linked Immunosorbent Assay.

Methods Mol Biol 2019 ;1901:229-237

Department of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark.

Antibodies to Ro52/Ro60 (SSA) and La (SSB) are strongly associated to the autoimmune disease primary Sjögren's syndrome and are important in the serologic diagnosis of the disease. Several methods for detection of these antibodies exist such as indirect immunofluorescence, commercial western blot kits, in-house assays, and numerous commercial enzyme-linked immunosorbent assays (ELISAs). Dependent on the type of assay, sensitivity and specificity may vary notably. Read More

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January 2019

Profiling of N-Methyladenosine in Zika Virus RNA and Host Cellular mRNA.

Methods Mol Biol 2019 ;1870:209-218

Department of Pediatrics and Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.

N-Methylation of adenosine (mA) in viral RNA was first identified in Rous sarcoma virus, influenza virus, and SV40 virus several decades ago. More recently, human immunodeficiency virus-1, hepatitis C virus, and Zika virus (ZIKV) RNAs have also been reported to be modified by mA, highlighting the significance of this posttranscriptional RNA modification. Nevertheless, the functions of mA and their roles in the context of viral infections are not completely understood. Read More

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January 2019

Anti-obesity effects of kaempferol by inhibiting adipogenesis and increasing lipolysis in 3T3-L1 cells.

J Physiol Biochem 2018 Dec 12. Epub 2018 Dec 12.

Facultad de Salud Pública y Nutrición, Centro de Investigación en Nutrición y Salud Pública, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico.

Kaempferol is a natural flavonoid widely found in fruits, vegetables, and tea. Kaempferol possesses beneficial biological properties such as anti-inflammatory and antioxidant activities. Positive energy balance during obesity correlates with a pro-inflammatory chronic state. Read More

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December 2018
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Biomarkers of Bad Biology: Curse or a Blessing?

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Division of Surgical Oncology, Department of Surgery, University of California, San Diego, La Jolla, USA.

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December 2018

Pancreaticoduodenectomy with Mesocaval Shunt for Locally Advanced Pancreatic Adenocarcinoma.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1484, Houston, TX, USA.

Introduction: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels.

Methods: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit. Read More

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December 2018

A Binding Potency Assay for Pritumumab and Ecto-Domain Vimentin.

Methods Mol Biol 2019 ;1904:401-415

Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, CA, USA.

Pritumumab, a natural human IgG1kappa mAb, was isolated from the regional lymph node of a patient with cervical cancer. This antibody has been reported to bind the cytoskeletal protein vimentin, and to cell surface expressed vimentin referred to as ecto-domain vimentin (EDV). Here, we report details of the development of a potency of binding assay for pritumumab as a prerequisite before pursuing clinical trials. Read More

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January 2019

Previous Adverse Outcome of Term Pregnancy and Risk of Preterm Birth in Subsequent Pregnancy.

Matern Child Health J 2018 Dec 11. Epub 2018 Dec 11.

The California Preterm Birth Initiative, University of California, San Francisco, San Francisco, CA, USA.

Objective Evaluate risk of preterm birth (PTB, < 37 completed weeks' gestation) among a population of women in their second pregnancy with previous full term birth but other adverse pregnancy outcome. Methods The sample included singleton live born infants between 2007 and 2012 in a birth cohort file maintained by the California Office of Statewide Health Planning and Development. The sample was restricted to women with two pregnancies resulting in live born infants and first birth between 39 and 42 weeks' gestation. Read More

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December 2018

The Effect of MPP+ on the Viability of Primary Cortical Astrocytes Isolated from Female and Male Wistar Rats of Different Ages.

Cell Mol Neurobiol 2018 Dec 11. Epub 2018 Dec 11.

Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, 09340, Ciudad de México, Mexico.

Although age is known to be the main risk for developing chronic and neurodegenerative diseases, those illnesses have a different prevalence depending on the sex. It has been questioned whether genetic and hormonal differences are preserved in primary cultures from individuals of different genders. Therefore, here we studied the susceptibility of astrocytes, obtained from female and male Wistar rats of different ages (newborn, 9 and 24 months-old), to the well-known toxin MPP+ after 2 weeks in vitro, at different concentrations and exposure times. Read More

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December 2018

Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort.

Clin Rheumatol 2018 Dec 12. Epub 2018 Dec 12.

Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen - EsSalud, Lima, Peru.

Objective: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients.

Methods: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine levels and who had at least one subsequent visit were included. Read More

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December 2018

My best case: homeopathic management of adverse effects of tamoxifen.

Wien Med Wochenschr 2018 Dec 11. Epub 2018 Dec 11.

General Practice Department, Faculty of Medicine, Strasbourg University, Strasbourg, France.

Background: Nearly half of patients discontinue tamoxifen hormone therapy early because of side effects, thus increasing the risk of breast cancer recurrence. Could a homeopathic treatment improve compliance?

Methods: A patient suffering from side effects of tamoxifen was seen in consultation every 2 months for 10 months by a senior homeopathic doctor and a registrar.

Results: Case analysis and repertorisation led to the identification of Pulsatilla as the simillimum drug and tamoxifen 7c as the etiological treatment. Read More

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December 2018
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Interleukin-22 promotes tumor angiogenesis.

Angiogenesis 2018 Dec 11. Epub 2018 Dec 11.

Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA.

T17 cells play important yet complex roles in cancer development and progression. We previously reported that T17 cells and IL-17 mediate resistance to anti-VEGF therapy by inducing recruitment of immunosuppressive and proangiogenic myeloid cells to the tumor microenvironment. Here, we demonstrate that IL-22, a key effector cytokine expressed by T17 cells, directly acts on endothelial cells to promote tumor angiogenesis. Read More

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December 2018

Does fire disturbance affect ant community structure? Insights from spatial co-occurrence networks.

Oecologia 2018 Dec 11. Epub 2018 Dec 11.

Instituto Multidisciplinario de Biología Vegetal (IMBIV), CONICET-Universidad Nacional de Córdoba, Vélez Sarsfield 1611, 5000, Córdoba, Argentina.

The coexistence of several species involves a complex mix of positive and negative interactions that can be represented as networks. As much as other ecological features, patterns of multispecies co-occurrence are susceptible to anthropogenic disturbance. In ant communities, wildfires may enhance competitive interactions by benefiting active, aggressive species, and by increasing encounter probabilities through decreased space availability. Read More

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December 2018