480,782 results match your criteria La Revue de medecine interne / fondee ... par la Societe nationale francaise de medecine interne[Journal]


Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Alcohol 2018 Aug 24;77:11-18. Epub 2018 Aug 24.

Department of Surgery, Alcohol Research Program, Burn & Shock Trauma Research Institute, Loyola University Chicago Health Sciences Division, Maywood, IL, United States. Electronic address:

On January 26, 2018, the 23rd annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado. The meeting consisted of plenary sessions with oral presentations and a poster presentation session. There were four plenary sessions that covered a wide range of topics relating to alcohol use: Alcohol and Liver Disease; Alcohol, Inflammation and Immune Response; Alcohol and Organ Injury; Heath Consequences and Alcohol Drinking. Read More

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http://dx.doi.org/10.1016/j.alcohol.2018.08.010DOI Listing

The organization of the basal ganglia functional connectivity network is non-linear in Parkinson's disease.

Neuroimage Clin 2019 Feb 3;22:101708. Epub 2019 Feb 3.

Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Spain. Electronic address:

The motor symptoms in Parkinson's disease (PD) have been linked to changes in the excitatory/inhibitory interactions of centers involved in the cortical-subcortical closed-loop circuits which connect basal ganglia (BG) and the brain cortex. This approach may explain some motor symptoms of PD but not others, which has driven the study of BG from new perspectives. Besides their cortical-subcortical linear circuits, BG have a number of subcortical circuits which directly or indirectly connect each BG with all the others. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101708DOI Listing
February 2019

Identification and differentiation of gluteus medius tendon pathology using ultrasound and magnetic resonance imaging.

Musculoskelet Sci Pract 2019 Feb 7;41:1-5. Epub 2019 Feb 7.

Discipline of Physiotherapy, Faculty of Health, University of Canberra, Canberra, 2617, Australia; Research Institute for Sport and Exercise, University of Canberra, 2617, Australia.

Background: It has been suggested that imaging findings play a role in directing treatment for Greater Trochanteric Pain Syndrome. Structural diagnoses associated with Greater Trochanter Pain Syndrome include gluteal tendinosis, and partial- or full-thickness gluteal tendon tears. However, few studies have compared imaging to confirmed tendon pathology observed during surgery. Read More

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http://dx.doi.org/10.1016/j.msksp.2019.01.011DOI Listing
February 2019

Preventing legionellosis outbreaks by a quick detection of airborne Legionella pneumophila.

Environ Res 2019 Jan 15;171:546-549. Epub 2019 Jan 15.

Escuela Técnica Superior de Ingenieros Industriales, Universidad Politécnica de Madrid (ETSII-UPM), C/José Gutiérrez Abascal, 2, E-28006 Madrid, Spain; Facultad de Farmacia, Universidad de Castilla-La Mancha (FF-UCLM), Avda. del Dr. José María Sánchez Ibáñez, s/n, E-02071 Albacete, Spain. Electronic address:

Legionellosis is a severe pneumonic infection caused by inhaling bacteria of the genus Legionella. Most cases reported in the USA and Europe are associated with the species Legionella pneumophila. This Gram-negative bacterium can survive within a wide spectrum of temperatures, and be transmitted via aerosols from multiple aquatic sources: fountains, thermal spas and other water systems. Read More

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http://dx.doi.org/10.1016/j.envres.2019.01.032DOI Listing
January 2019

Impact of winter droughts on air pollution over Southwest China.

Sci Total Environ 2019 Jan 28;664:724-736. Epub 2019 Jan 28.

Key Laboratory of Arid Climate Change and Reducing Disaster in Gansu Province, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China.

The meteorological causes of winter droughts over Southwest China (SWC) have been widely investigated in recent years; however, little information is available on the impact of these droughts on air pollution. This study (1) characterized and quantified the impact of winter droughts on air pollution over SWC and (2) investigated the atmospheric teleconnections associated with the winter droughts in this region using air pollution monitoring data, routinely observed meteorological data, and National Centers for Environmental Prediction/National Center for Atmospheric Research and ERA-Interim reanalysis data. The main results are as follows: (1) A surface high pressure system together with a weak descent in the middle troposphere was the main cause of the SWC drought in December 2017. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.335DOI Listing
January 2019

Temperature variability and hospitalization for ischaemic heart disease in Brazil: A nationwide case-crossover study during 2000-2015.

Sci Total Environ 2019 Feb 5;664:707-712. Epub 2019 Feb 5.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Australia. Electronic address:

Background: Previous studies have suggested a potential relationship between temperature variability (TV) and ischaemic heart disease (IHD) but the nature and strength differ between studies. We quantify the association between TV and risk of hospitalization for IHD across Brazilian regions and examine how the relationship varies across important population subgroups.

Methods: Data on hospitalization for IHD and meteorological parameters were collected from 1814 cities during 2000-2015. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.066DOI Listing
February 2019

The influence of anthropogenic organic matter and nutrient inputs on the food web structure in a coastal lagoon receiving agriculture and shrimp farming effluents.

Sci Total Environ 2019 Jan 28;664:635-646. Epub 2019 Jan 28.

Centro de Investigación en Alimentación y Desarrollo, A.C. Coordinación de Ciencia de los Alimentos, Unidad Hermosillo, Carretera Gustavo Enrique Astiazarán Rosas 46, Colonia La Victoria, Hermosillo 83304, Sonora, Mexico. Electronic address:

In this study, we elucidated the impacts of allochthonous organic matter (OM) and nutrients (N and P) inputs coming from agriculture and shrimp aquaculture activities on food web structure in a subtropical coastal lagoon located on the central-east of the Gulf of California. This coastal lagoon is highly influenced by OM and nutrients inputs by a large agriculture district and aquaculture development center in Mexico. We also selected a second coastal lagoon, without direct OM and nutrients inputs, considered as a 'pristine' ecosystem. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.343DOI Listing
January 2019

Climate-growth relationships in a Larix decidua Mill. network in the French Alps.

Sci Total Environ 2019 Feb 5;664:554-566. Epub 2019 Feb 5.

Retired from Aix Marseille Université, CNRS, Ministère de la Culture et de la Communication, CCJ UMR 7299, 13094 Aix en Provence, France.

A better understanding of the respective role of key climatic variables on tree growth is crucial for an accurate assessment of how ongoing global changes may affect both dynamics and distribution of forest tree species in the future. The aim of this study was (i) to explore growth patterns of European larch (Larix decidua Mill.) through a network of tree-ring chronologies developed for the French Alps and (ii) to identify the main climatic drivers explaining radial growth. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.404DOI Listing
February 2019

Experimental and Monte Carlo characterization of radionuclidic impurities originated from proton irradiation of [O]HO in a modern medical cyclotron.

Appl Radiat Isot 2019 Jan 31;146:84-89. Epub 2019 Jan 31.

INSTM, Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali, Unità di Pavia, Via Taramelli 12, I-27100, Pavia, Italy.

In this work we present a characterization of the radionuclidic impurities originated by proton irradiation of enriched water [O]HO in a medical cyclotron through Monte Carlo simulations and experimental measurements. A set of standard samples of enriched water loaded in the cyclotron target cell have been irradiated at 30 μA proton current for 1 h each and, after an appropriate cooling time, measured by HPGe gamma spectrometry. In this way it was possible to study the direct release of radionuclidic impurities from target components as well as the release as a function of target ageing. Read More

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http://dx.doi.org/10.1016/j.apradiso.2019.01.026DOI Listing
January 2019

Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey.

J Proteomics 2019 Feb 11. Epub 2019 Feb 11.

Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany. Electronic address:

We report on the variable venom composition of a population of the Caucasus viper (Vipera kaznakovi) in Northeastern Turkey. We applied a combination of venom gland transcriptomics, and de-complexing bottom-up and top-down venomics. In contrast to sole bottom-up venomics approaches and gel or chromatography based venom comparison, our combined approach enables a faster and more detailed comparison of venom proteomes from multiple individuals. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.02.004DOI Listing
February 2019

Low carbon heating and cooling by combining various technologies with Aquifer Thermal Energy Storage.

Sci Total Environ 2019 Jan 15;665:1-10. Epub 2019 Jan 15.

Arcadis Belgium nv/sa, Gent, Belgium.

A transition to a low carbon energy system is needed to respond to global challenge of climate change mitigation. Aquifer Thermal Energy Storage (ATES) is a technology with worldwide potential to provide sustainable space heating and cooling by (seasonal) storage and recovery of heat in the subsurface. However, adoption of ATES varies strongly across Europe, because of both technical as well as organizational barriers, e. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.135DOI Listing
January 2019

The role of early life food sensitization in adolescent lung function: Results from two birth cohort studies.

J Allergy Clin Immunol Pract 2019 Feb 11. Epub 2019 Feb 11.

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia;; Murdoch Children's Research Institute, Melbourne, Australia. Electronic address:

Background: It is unclear whether early life food sensitization (as opposed to aeroallergen sensitization) is associated with subsequent poor lung function.

Objectives: We investigated the associations between food sensitization in the first two years of life and lung function at 12 to 18 years and whether these observed associations are mediated through aeroallergen sensitization or asthma.

Methods: We used data from a high-risk cohort (MACS) and a population-based (LISAplus) cohort. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.050DOI Listing
February 2019

Prophylactic hypothermia for traumatic brain injury patients: It's not cool to be, cooled.

Anaesth Crit Care Pain Med 2019 Feb 11. Epub 2019 Feb 11.

Department of anaesthesia and intensive care medicine, CHRU La Cavale Blanche, Brest, France; UFR de médecine, Université de Bretagne occidentale, Brest, France; ANZIC research centre, Monash University, Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.accpm.2019.02.002DOI Listing
February 2019

Essential role of JunD in cell proliferation is mediated via MYC signaling in prostate cancer cells.

Cancer Lett 2019 Feb 11. Epub 2019 Feb 11.

Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA. Electronic address:

JunD, a member of the AP-1 family, is essential for cell proliferation in prostate cancer (PCa) cells. We recently demonstrated that JunD knock-down (KD) in PCa cells results in cell cycle arrest in G-phase concomitant with a decrease in cyclin D1, Ki67, and c-MYC, but an increase in p21 levels. Furthermore, the over-expression of JunD significantly increased proliferation suggesting JunD regulation of genes required for cell cycle progression. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.005DOI Listing
February 2019

Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons.

Neurobiol Dis 2019 Feb 11. Epub 2019 Feb 11.

Exp. Neurology, Goethe University Medical School, 60590 Frankfurt am Main, Germany. Electronic address:

Parkinson's disease (PD) is the second most frequent neurodegenerative disorder in the old population. Among its monogenic variants, a frequent cause is a mutation in the Parkin gene (Prkn). Deficient function of Parkin triggers ubiquitous mitochondrial dysfunction and inflammation in the brain, but it remains unclear how selective neural circuits become vulnerable and finally undergo atrophy. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.02.008DOI Listing
February 2019

Genomic structural diversity in Criollo Argentino horses: Analysis of copy number variations.

Gene 2019 Feb 11. Epub 2019 Feb 11.

IGEVET - Instituto de Genética Veterinaria "Ing. Fernando N Dulout" (UNLP CONICET LA PLATA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118 S/N, 1900 La Plata, Argentina. Electronic address:

Copy number variation (CNV) has been proved to be widespread in human, animal and plant genomes. Together with single nucleotide polymorphisms (SNPs), CVNs play a key role in genetic diversity. In this study, genome-wide detection of CNVs was performed based on SNP data from 24 Criollo Argentino horses genotyped with the GGP Equine70k array. Read More

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http://dx.doi.org/10.1016/j.gene.2018.12.067DOI Listing
February 2019

Mutational analysis of CFTR in the Ecuadorian population using next-generation sequencing.

Gene 2019 Feb 11. Epub 2019 Feb 11.

Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud, Universidad Tecnológica Equinoccial, Quito, Ecuador.

The frequency distributions of cystic fibrosis variants are heterogeneous in Ecuador because of the genetic admixture of its population. The aim of this study was to identify disease-causing variants among Ecuadorian cystic fibrosis (CF) patients by next-generation sequencing (NGS) of the entire cystic fibrosis transmembrane conductance regulator (CFTR) gene. The results showed an approximation of the frequencies of pathogenic variants in the population under study and an optimal mutation panel for routine first-line CF molecular diagnosis. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.015DOI Listing
February 2019

Cross-talk between the RcsCDB and RstAB systems to control STM1485 gene expression in Salmonella Typhimurium during acid-resistance response.

Biochimie 2019 Feb 11. Epub 2019 Feb 11.

Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, and Instituto de Química Biológica "Dr. Bernabé Bloj", Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI, San Miguel de Tucumán, Tucumán, Argentina. Electronic address:

Bacterial survive and respond to adverse changes in the environment by regulating gene transcription through two-component regulatory systems. In Salmonella Typhimurium the STM1485 gene expression is induced under low pH (4.5) during replication inside the epithelial host cell, but it is not involved in sensing or resisting to this condition. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.02.005DOI Listing
February 2019

High-resolution characterization of allelic and haplotypic HLA frequency distribution in a Spanish population using high-throughput next-generation sequencing.

Hum Immunol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

Next-generation sequencing (NGS) at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1 and -DRB3/4/5 loci was performed on 282 healthy unrelated individuals from different major regions of Spain. High-resolution HLA genotypes defined by full sequencing of class I loci and extended coverage of class II loci were obtained to determine allele frequencies and also to estimate extended haplotype frequencies. HLA alleles were typed at the highest resolution level (4-field level, 4FL); with exception of a minor deviation in HLA-DPA1, no statistically significant deviations from expected Hardy Weinberg Equilibrium (HWE) proportions were observed for all other HLA loci. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.005DOI Listing
February 2019

Surveillance of Aedes aegypti indoors and outdoors using Autocidal Gravid Ovitraps in South Texas during local transmission of Zika virus, 2016 to 2018.

Acta Trop 2019 Feb 11. Epub 2019 Feb 11.

Department of Entomology, Texas A&M University, College Station, Texas, United States. Electronic address:

The yellow fever mosquito, Aedes aegypti, has facilitated the re-emergence of dengue virus (DENV) and emergence of chikungunya virus (CHIKV) and Zika virus (ZIKV) in the Americas and the Caribbean. The recent transmission of these arboviruses in the continental United States has been limited, to date, to South Florida and South Texas despite Ae. aegypti occurring over a much larger geographical region within the country. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.006DOI Listing
February 2019

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors.

Cell Host Microbe 2019 Feb;25(2):324-335.e4

Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada; Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Winnipeg, MB, Canada. Electronic address:

Breastmilk contains a complex community of bacteria that may help seed the infant gut microbiota. The composition and determinants of milk microbiota are poorly understood. Among 393 mother-infant dyads from the CHILD cohort, we found that milk microbiota at 3-4 months postpartum was dominated by inversely correlated Proteobacteria and Firmicutes, and exhibited discrete compositional patterns. Read More

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http://dx.doi.org/10.1016/j.chom.2019.01.011DOI Listing
February 2019

[Quality of Life of Adolescents with Homozygous Sickle-Cell Disease Managed at the Brazzaville Teaching Hospital (Congo)].

Bull Soc Pathol Exot 2018 ;111(1):46-50

Service de pédiatrie nourrissons, CHU de Brazzaville, faculté des sciences de la santé, université Marien-Ngouabi, Brazzaville, BP 32, CG-Brazzaville, Congo.

Adolescence is a particular age group in terms of psychological and somatic changes. Thus, the experience of a chronic disease such as sickle-cell disease is different compared to the younger child who depends entirely on his parents. The purpose of this study is to assess the quality of life and to identify the determinants of good quality of life of such teenagers. Read More

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http://dx.doi.org/10.3166/bspe-2018-0006DOI Listing
January 2018

[Epidemiological Situation of the Human African Trypanosomiasis in the Bilolo Municipality of Central African Republic].

Bull Soc Pathol Exot 2018 ;111(1):12-16

Faculté des sciences de la santé, université de Bangui, BP 1450, Bangui, République centrafricaine.

The Human African Trypanosomiasis (HAT) is a disabling and fatal disease caused by a vector-borne parasite still impacting in residual hotbeds. The aim of our study was to update the epidemiological data of HAT in one of Central African Republic foci after the (2012-2014) period of conflict. The survey was carried out in 24 villages in the Bilolo's municipality where 4788 persons were examined by the CATT () technique. Read More

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http://dx.doi.org/10.3166/bspe-2018-0002DOI Listing
January 2018

[Update of knowledge on Neglected Diseases in Haiti: Mansonelliasis, Tungiasis, Leprosy, and Anthrax].

Bull Soc Pathol Exot 2018 ;111(1):17-23

Direction d'épidémiologie, de laboratoire et de recherches, 52 angle Delmas 33 et rue Charbonnières, Port-au-Prince, Haïti.

Haiti, like most limited-resources countries in the world, faces numerous neglected infectious diseases. They represent a real public health issue with lethal consequences especially in children. We are reviewing here the available literature on four neglected infectious diseases, mansonelliasis, tungiasis, leprosy and anthrax. Read More

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http://dx.doi.org/10.3166/bspe-2018-0005DOI Listing
January 2018

A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes.

Mol Nutr Food Res 2019 Feb 14:e1800967. Epub 2019 Feb 14.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Introduction: Few data exist examining the effects of whole grain (WG) versus refined grain (RG) diets on glucose-stimulated insulin secretion (GSIS) and β-cell function.

Methods: In a double-blind crossover randomized controlled trial, 13 sedentary prediabetic adults (37.2±1. Read More

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http://dx.doi.org/10.1002/mnfr.201800967DOI Listing
February 2019

Rosellinia necatrix infection induces differential gene expression between tolerant and susceptible avocado rootstocks.

PLoS One 2019 14;14(2):e0212359. Epub 2019 Feb 14.

Department of Genomics and Biotechnology, Fruticultura Subtropical y Mediterránea (IFAPA) Unidad Asociada de I+D+i al CSIC, Málaga, Spain.

Rosellinia necatrix is the causal agent of avocado white root rot (WRR). Control of this soil-borne disease is difficult, and the use of tolerant rootstocks may present an effective method to lessen its impact. To date, no studies on the molecular mechanisms regulating the avocado plant response towards this pathogen have been undertaken. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212359PLOS
February 2019

Public finances and tobacco taxation with product variety: Theory and application to Senegal and Nigeria.

PLoS One 2019 14;14(2):e0212015. Epub 2019 Feb 14.

Maastricht University, School of Business and Economics, Maastricht, The Netherlands.

This study endeavors to answer two questions: which category of excise taxes is more appropriate for Senegal and Nigeria and which consequences an increase of the tobacco taxes would have on the price, the demand and the tax revenues in each one of the two countries? To answer these questions, we adopt a double approach: first, a theoretical model of taxation with variety; and second, a simulation model to answer the second question. The results of the theoretical model indicate that, in the context of excise taxation, the number of products variety-or that of cigarette brands-directly affects both the degree of market concentration and the marginal effects of specific and ad valorem excise taxes on the price of tobacco. In addition, the comparison of the marginal effects of ad valorem and specific excise taxes depends on the marginal costs of production of different varieties weighted by the tax rates and the number of varieties. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212015PLOS
February 2019

HIV diagnoses in migrant populations in Australia-A changing epidemiology.

PLoS One 2019 14;14(2):e0212268. Epub 2019 Feb 14.

Kirby Institute for Infection and Immunity, UNSW Sydney, Sydney, Australia.

Introduction: We conducted a detailed analysis of trends in new HIV diagnoses in Australia by country of birth, to understand any changes in epidemiology, relationship to migration patterns and implications for public health programs.

Methods: Poisson regression analyses were performed, comparing the age-standardised HIV diagnosis rates per 100,000 estimated resident population between 2006-2010 and 2011-2015 by region of birth, with stratification by exposure (male-to-male sex, heterosexual sex-males and females). Correlation between the number of permanent and long-term arrivals was also explored using linear regression models. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212268PLOS
February 2019

QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease.

J Integr Bioinform 2019 Feb 14. Epub 2019 Feb 14.

Instituto de Ciencias e Ingeniería de la Computación (UNS-CONICET), Departamento de Ciencias e Ingeniería de la Computación, Universidad Nacional del Sur (UNS), Bahía Blanca, Argentina.

Parkinson's disease is one of the most common neurodegenerative illnesses in older persons and the leucine-rich repeat kinase 2 (LRRK2) is an auspicious target for its pharmacological treatment. In this work, quantitative structure-activity relationship (QSAR) models for identification of putative inhibitors of LRRK2 protein are developed by using an in-house chemical library and several machine learning techniques. The methodology applied in this paper has two steps: first, alternative subsets of molecular descriptors useful for characterizing LRRK2 inhibitors are chosen by a multi-objective feature selection method; secondly, QSAR models are learned by using these subsets and three different strategies for supervised learning. Read More

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http://dx.doi.org/10.1515/jib-2018-0063DOI Listing
February 2019

The effect of DOAC-Stop on lupus anticoagulant testing in plasma samples of venous thromboembolism patients receiving direct oral anticoagulants.

Clin Chem Lab Med 2019 Feb 14. Epub 2019 Feb 14.

Institute of Cardiology, Jagiellonian University Medical College and John Paul II Hospital, Krakow, Poland.

Background Direct oral anticoagulants (DOACs) cause false positive lupus anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing in vitro effects of DOACs, on LA testing in anticoagulated patients. Methods We assessed 75 venous thromboembolism patients aged 44. Read More

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http://dx.doi.org/10.1515/cclm-2018-1197DOI Listing
February 2019

Submaximal heart rate seems inadequate to prescribe and monitor intensified training.

Eur J Sport Sci 2019 Feb 14:1-10. Epub 2019 Feb 14.

a Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences , Vrije Universiteit Amsterdam , Amsterdam , Netherlands.

The aim of this study is to investigate whether the change in (sub)maximal heart rate after intensified training is associated with the change in performance. Thirty subjects were recruited who performed cardiopulmonary exercise tests to exhaustion 2 weeks before (pre), 1 week after (post) and 5 weeks after (follow-up) an 8-day non-competitive amateur cycling event (TFL). The exercise volume during the TFL was 7. Read More

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http://dx.doi.org/10.1080/17461391.2019.1571112DOI Listing
February 2019

Multitarget-directed ligands for neurodegenerative diseases: real opportunity or blurry mirage?

Future Med Chem 2019 Feb 14. Epub 2019 Feb 14.

Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.

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http://dx.doi.org/10.4155/fmc-2018-0249DOI Listing
February 2019

Zeolitic Intermetallics: LnNiSi (Ln = La-Nd).

J Am Chem Soc 2019 Feb 14. Epub 2019 Feb 14.

Materials Research Center for Element Strategy , Tokyo Institute of Technology , 4259 Nagatsuta , Midori-ku , Yokohama 226-8503 , Japan.

LnNiSi (Ln = La-Nd) comprising a three-dimensional NiSi framework has electrons in the crystallographic cavity space. In the temperature region 473-773 K, it accepts the insertion/de-insertion of hydrogen topotactically without a change in unitcell volume. The insertion of hydrogens into the cavity space is accompanied by a redox reaction with the orbitals of atoms constituting the cavity wall. Read More

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http://pubs.acs.org/doi/10.1021/jacs.8b12784
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http://dx.doi.org/10.1021/jacs.8b12784DOI Listing
February 2019
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Praticien, la visite médicale par un représentant est-elle une aide ou une entrave ?

Rev Med Suisse 2019 Feb;15(638):403-405

Fédération suisse des psychologues (FSP), Pavia, Portugal.

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February 2019

[ARFID - Avoidant and restrictive food intake disorder : clinical characteristics].

Rev Med Suisse 2019 Feb;15(638):394-397

Service de psychiatrie de l'enfant et de l'adolescent, Département de l'enfant et de l'adolescent, HUG, 1211 Genève 14.

Avoidant and restrictive food intake disorder (ARFID) is a « new » diagnosis introduced in the Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5) in 2013. ARFID is a heterogeneous disorder that seems to be common in clinical settings and is associated with high levels of physical and psychological comorbidity and impact on physical health and psychosocial functioning. We present an overview of the available literature on ARFID and describe the current understanding of its correlates. Read More

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February 2019

Analysis of the interfacial characteristics of BiVO/metal oxide heterostructures and its implication on their junction properties.

Phys Chem Chem Phys 2019 Feb 14. Epub 2019 Feb 14.

Surface Science Division, Department of Materials Science, Technical University Darmstadt, D-64287 Darmstadt, Germany.

The formation of heterostructures has proven to be a viable way to achieve high photoelectrochemical water splitting efficiencies with BiVO4 based photoanodes. Especially, cobalt and nickel based oxides are suitable low cost contact materials. However, the exact role of these contact materials is not yet completely understood because of the difficulty to individually quantify the effects of surface passivation, charge carrier separation and catalysis on the efficiency of a heterostructure. Read More

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http://dx.doi.org/10.1039/c8cp07483fDOI Listing
February 2019

An evaluation of sexually transmitted infection and odds of preterm or early term birth using propensity score matching.

Sex Transm Dis 2019 Feb 11. Epub 2019 Feb 11.

California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, USA.

Background: Few studies have examined the relationship between sexually transmitted infections (STIs) and preterm birth (<37 weeks gestation) by subtype (<32 weeks, 32 - 36 weeks, spontaneous, provider-initiated). Here, we evaluate the odds of preterm (by subtype) and early term (37 and 38 weeks gestation) birth in women with an STI compared to a propensity score matched reference population.

Methods: The sample was selected from California births in 2007-2012. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000985DOI Listing
February 2019

Clinical spectrum of central nervous system myelin oligodendrocyte glycoprotein autoimmunity in adults.

Curr Opin Neurol 2019 Feb 11. Epub 2019 Feb 11.

Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Hôpital Neurologique Pierre Wertheimer Hospices Civils de Lyon.

Purpose Of Review: The clinical interest for auto-antibodies against myelin oligodendrocyte glycoprotein (MOG) has recently reemerged, with the use of more specific detection methods. Large national cohorts have allowed characterizing a more precise clinical spectrum delineated by the presence of human MOG-antibodies.

Recent Findings: In adults with MOG-antibodies, optic neuritis is the most frequent clinical presentation, with features different from multiple sclerosis (MS), including bilateral involvement and predilection for the anterior part of the optic nerve. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000681DOI Listing
February 2019

A patient with a novel CNTNAP2 homozygous variant: further delineation of the CASPR2 deficiency syndrome and review of the literature.

Clin Dysmorphol 2019 Feb 12. Epub 2019 Feb 12.

Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Sciences Centre.

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http://dx.doi.org/10.1097/MCD.0000000000000259DOI Listing
February 2019

HIV-exposed uninfected compared with unexposed infants show the presence of leucocytes, lower lactoferrin levels and antimicrobial-resistant micro-organisms in the stool.

Paediatr Int Child Health 2019 Feb 14:1-10. Epub 2019 Feb 14.

a Laboratoire National de Santé Publique , Unités de Recherche et de Diagnostics Spécialisés , Libreville , Gabon.

Background: HIV-exposed uninfected (HEU)-infants have been shown to be particularly vulnerable to infections. In this population, disturbance of the gut micro-environment might increase their susceptibility to enteric diseases and even favour the translocation of bacteria in the bloodstream.

Methods: The gastro-intestinal micro-environment was explored in 22 HEU infants and 16 HIV-unexposed (HU) infants aged 6-24 weeks. Read More

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http://dx.doi.org/10.1080/20469047.2019.1577063DOI Listing
February 2019

Age-Related Patterns of DNA Detection and Specific IgG Subclasses in Healthy HHV-6- and HHV-7-Infected Individuals.

Viral Immunol 2019 Feb 14. Epub 2019 Feb 14.

1 Medical Bacteriology and Virology, School of Medical Sciences, National University of Córdoba, Córdoba, Argentina.

Human herpesvirus 6A (HHV-6A), Human herpesvirus 6B (HHV-6B), and Human herpesvirus 7 (HHV-7) can persist by establishing a lifelong infection which could have implications on the immunocompetent host. The aim of this work is to contribute with some knowledge about the HHV-6 A/B and HHV-7 infection in healthy individuals. We have carried out a longitudinal study in seropositive healthy individuals for the detection of viral DNA in saliva and plasma samples, and for determining a specific IgG isotype immune response, which enabled the performance of these viruses to be observed over time. Read More

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http://dx.doi.org/10.1089/vim.2018.0113DOI Listing
February 2019

PTSD and Attitudes Toward Guns Following Interpersonal Trauma.

J Interpers Violence 2019 Feb 14:886260519829766. Epub 2019 Feb 14.

2 Southeast Louisiana Veterans Health Care System, New Orleans, USA.

Gun violence is a serious public health concern that is currently grossly understudied. Gun attitudes are a potential risk factor for gun violence; however, factors related to gun attitudes have not been identified. Mental illness such as posttraumatic stress disorder (PTSD) is commonly discussed as a key factor in gun violence, despite research lacking in this area, and it is unknown whether symptoms of PTSD and probable PTSD are associated with more positive attitudes toward guns. Read More

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http://dx.doi.org/10.1177/0886260519829766DOI Listing
February 2019

Patient-reported outcomes 1 to 5 years after ACL reconstruction: effect of combined injury, and associations with MRI-defined osteoarthritis features.

Arthritis Care Res (Hoboken) 2019 Feb 14. Epub 2019 Feb 14.

La Trobe Sport & Exercise Medicine Research Centre, School of Allied Health, La Trobe University, Bundoora, Australia.

Objective: Persistent symptoms and poor quality of life (QoL) are common following anterior cruciate ligament reconstruction (ACLR). We aimed to determine the influence of a combined ACL injury (i.e. Read More

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http://dx.doi.org/10.1002/acr.23854DOI Listing
February 2019

C1-Linked Spirobifluorene Dimers: Pure Hydrocarbon Hosts for High-Performance Blue Phosphorescent OLEDs.

Angew Chem Int Ed Engl 2019 Feb 14. Epub 2019 Feb 14.

Univ Rennes, CNRS, ISCR- UMR 6226, 35000, Rennes, France.

Reported here are C1-linked spiro-bifluorene dimers. A comprehensive study is carried out to analyze the electronic properties of these highly twisted structures. This work shows that the C1-position enables the design of pure hydrocarbon materials, with a high triplet energy, for hosting blue phosphors in efficient phosphorescent OLEDs (PhOLEDs). Read More

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http://dx.doi.org/10.1002/anie.201813604DOI Listing
February 2019

Acanthosis nigricans, hypochondroplasia, and FGFR3 mutations: Findings with five new patients, and a review of the literature.

Pediatr Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, CHU Nantes, Nantes, France.

Early development of extensive acanthosis nigricans (AN) is a key feature in some patients who have hypochondroplasia (HCH) in association with FGFR3 mutations. We here report regarding five new patients with HCH who exhibited AN, and we compare their characteristics to the eight patients previously described in the literature. In these patients, the AN lesions began in childhood, and they were extensive. Read More

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http://dx.doi.org/10.1111/pde.13748DOI Listing
February 2019

Physiological Changes from Violence-Induced Stress and Trauma Enhance HIV Susceptibility Among Women.

Curr HIV/AIDS Rep 2019 Feb 14. Epub 2019 Feb 14.

Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0507, La Jolla, CA, 92093-0507, USA.

Purpose Of Review: This theoretical review identifies physiological mechanisms by which violence against women (VAW) may increase women's susceptibility to HIV through trauma, stress, and immune dysfunction.

Recent Findings: Research documents systemic and local immune responses are related to stress and trauma from abuse across the life course (i.e. Read More

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http://dx.doi.org/10.1007/s11904-019-00435-8DOI Listing
February 2019

Recommendations for follow-up of colorectal cancer survivors.

Clin Transl Oncol 2019 Feb 14. Epub 2019 Feb 14.

Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Colorectal cancer (CRC) is one of the tumours with the highest incidence and mortality in the Spanish population. Nevertheless, the advances in prevention and treatment have contributed to an increased number of patients who survive for prolonged periods of time. In addition, despite recurrences, improved survival following metastasis resection is likewise on the rise. Read More

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http://dx.doi.org/10.1007/s12094-019-02059-1DOI Listing
February 2019

Gene expression atlas of embryo development in Arabidopsis.

Plant Reprod 2019 Feb 14. Epub 2019 Feb 14.

Aquatic and Crop Resource Development, National Research Council Canada, 110 Gymnasium Place, Saskatoon, SK, S7N 0W9, Canada.

Embryogenesis represents a critical phase in the life cycle of flowering plants. Here, we characterize transcriptome landscapes associated with key stages of embryogenesis by combining an optimized method for the isolation of developing Arabidopsis embryos with high-throughput RNA-seq. The resulting RNA-seq datasets identify distinct overlapping patterns of gene expression, as well as temporal shifts in gene activity across embryogenesis. Read More

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http://dx.doi.org/10.1007/s00497-019-00364-xDOI Listing
February 2019