902 results match your criteria LASEK


Comparison of the posterior corneal elevation and biomechanics after SMILE and LASEK for myopia: a short- and long-term observation.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 14. Epub 2019 Jan 14.

Department of Ophthalmology, Eye and ENT Hospital, Fudan University, No. 83 Fenyang Road, Shanghai, 200031, China.

Purpose: This study compares the posterior corneal elevation and corneal biomechanics after small incision lenticule extraction (SMILE) and laser-assisted subepithelial keratomileusis (LASEK) for myopia correction in a short- and long-term observation.

Methods: This prospective study included 32 patients in the SMILE group and 32 patients in the LASEK group. Corneal posterior central elevation (PCE), posterior mean elevation (PME), corneal back power (Kb), and anterior chamber depth (ACD) were evaluated with Pentacam, and intraocular pressure (IOP), corneal hysteresis (CH), and corneal resistance factor (CRF) were evaluated with the ORA at pre-operation and 3 months and 3 years post-operation. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00417-018-04227-5
Publisher Site
http://dx.doi.org/10.1007/s00417-018-04227-5DOI Listing
January 2019
1 Read

Is ITP really a desirable indication for teaching laparoscopic splenectomy? Cohort study.

Acta Chir Belg 2019 Jan 9:1-8. Epub 2019 Jan 9.

a 2nd Department of General Surgery , Jagiellonian University Medical College , Kraków , Poland.

Background: We aimed to evaluate the outcomes of laparoscopic splenectomy (LS) in patients with immune thrombocytopenic purpura (ITP) compared with operated for other indications.

Methods: Retrospective cohort study of patients who underwent LS in 1998-2017. Group 1 consisted of 256 patients operated for ITP, and Group 2 of 231 operated for other indications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00015458.2018.1545743DOI Listing
January 2019
1 Read

Discharge of biocidal products from healthcare activities into a sewage system-a case study at a French university hospital.

Environ Sci Pollut Res Int 2018 Dec 19. Epub 2018 Dec 19.

Institute of Chemistry Materials and Natural Resources of Poitiers (IC2MP UMR 7285), University of Poitiers, 1 rue Marcel Doré, Bâtiment B1, TSA 41105, 86073, Poitiers Cedex 9, France.

This study focused on the presence of three biocidal products specific to healthcare facilities, i.e. chlorhexidine digluconate (CHD), bis(aminopropyl)laurylamine (BAPLA), and didecyldimethylammonium chloride (DDAC), in a hospital sewage system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-018-3882-1DOI Listing
December 2018
1 Read

The significant impact of age on the clinical outcomes of laparoscopic appendectomy: Results from the Polish Laparoscopic Appendectomy multicenter large cohort study.

Medicine (Baltimore) 2018 Dec;97(50):e13621

Faculty of Health Sciences, Powiślańska School in Kwidzyn, Kwidzyn.

Acute appendicitis (AA) is the most common surgical emergency and can occur at any age. Nearly all of the studies comparing outcomes of appendectomy between younger and older patients set cut-off point at 65 years. In this multicenter observational study, we aimed to compare laparoscopic appendectomy for AA in various groups of patients with particular interest in the elderly and very elderly in comparison to younger adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000013621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320074PMC
December 2018

Quest for the optimal technique of laparoscopic splenectomy - vessels first or hilar transection?

Wideochir Inne Tech Maloinwazyjne 2018 Dec 30;13(4):460-468. Epub 2018 May 30.

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Introduction: Throughout our 20 years of experience, we have used several different techniques for laparoscopic splenectomy (LS). However, two methods have been used most frequently: "vessels first" and "hilar transection".

Aim: To evaluate the outcomes of LS performed with these two different approaches. Read More

View Article

Download full-text PDF

Source
https://www.termedia.pl/doi/10.5114/wiitm.2018.76071
Publisher Site
http://dx.doi.org/10.5114/wiitm.2018.76071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280088PMC
December 2018
5 Reads

Corneal Surface Ablation Laser Refractive Surgery for the Correction of Myopia: A Network Meta-analysis.

J Refract Surg 2018 Nov;34(11):726-735

Purpose: To systematically compare the efficacy, predictability, safety, postoperative haze, pain scores, and epithelial healing time of four corneal surface ablation procedures.

Methods: PubMed, Embase, Cochrane Library, and the U.S. Read More

View Article

Download full-text PDF

Source
https://www.healio.com/doiresolver?doi=10.3928/1081597X-2018
Publisher Site
http://dx.doi.org/10.3928/1081597X-20180905-01DOI Listing
November 2018
9 Reads

Genome Structure of the Opportunistic Pathogen () and Identification of Putative Virulence Factors.

Front Microbiol 2018 25;9:2553. Epub 2018 Oct 25.

Department of Bacterial Genetics, Faculty of Biology, University of Warsaw, Warsaw, Poland.

Bacteria of the genus are common components of the microbiomes of many naturally- and anthropogenically shaped environments. One species, , is unique within the genus because it is associated with opportunistic human infections. Therefore, strains of may serve as an interesting model to study the transition from a saprophytic to a pathogenic lifestyle in environmental bacteria. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fmicb.2018.02553
Publisher Site
http://dx.doi.org/10.3389/fmicb.2018.02553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209633PMC
October 2018
4 Reads

The Safety of Selective Use of Splenic Flexure Mobilization in Sigmoid and Rectal Resections-Systematic Review and Meta-Analysis.

J Clin Med 2018 Oct 27;7(11). Epub 2018 Oct 27.

Department of General Surgery, Jagiellonian University Medical College, Krakow 31-501, Poland.

Background: According to traditional textbooks on surgery, splenic flexure mobilization is suggested as a mandatory part of open rectal resection. However, its use in minimally invasive access seems to be limited. This stage of the procedure is considered difficult in the laparoscopic approach. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2077-0383/7/11/392
Publisher Site
http://dx.doi.org/10.3390/jcm7110392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262468PMC
October 2018
5 Reads

Ethanol acts on KCNK13 potassium channels in the ventral tegmental area to increase firing rate and modulate binge-like drinking.

Neuropharmacology 2019 01 14;144:29-36. Epub 2018 Oct 14.

Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, 60612, USA; Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, 60612, USA. Electronic address:

Alcohol excitation of the ventral tegmental area (VTA) is important in neurobiological processes related to the development of alcoholism. The ionotropic receptors on VTA neurons that mediate ethanol-induced excitation have not been identified. Quinidine blocks ethanol excitation of VTA neurons, and blockade of two-pore potassium channels is among the actions of quinidine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286249PMC
January 2019
1 Read

Pancreatoduodenectomy for pancreatic head tumors in the elderly - Systematic review and meta-analysis.

Surg Oncol 2018 Sep 17;27(3):346-364. Epub 2018 May 17.

2ndDepartment of General Surgery, Jagiellonian University Medical College, Kopernika 21, 31-501, Krakow, Poland; Centre for Research, Training and Innovation in Surgery (CERTAIN Surgery), Krakow, Poland.

The age at which patients are undergoing pancreatoduodenectomy is increasing worldwide. The data on the outcome of this surgical procedure in the elderly is constantly expanding. This meta-analysis aims to assess the safety of pancreatoduodenectomy in elderly population, primarily focusing on morbidity and mortality. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09607404183013
Publisher Site
http://dx.doi.org/10.1016/j.suronc.2018.05.021DOI Listing
September 2018
7 Reads

Histone Deacetylase Inhibitor Suberanilohydroxamic Acid Treatment Reverses Hyposensitivity to γ-Aminobutyric Acid in the Ventral Tegmental Area During Ethanol Withdrawal.

Alcohol Clin Exp Res 2018 Nov 7;42(11):2160-2171. Epub 2018 Sep 7.

Department of Physiology and Biophysics , University of Illinois at Chicago, Chicago, Illinois.

Background: The ventral tegmental area (VTA) is important for alcohol-related reward and reinforcement. Mouse VTA neurons are hyposensitive to γ-aminobutyric acid (GABA) during ethanol (EtOH) withdrawal, and GABA responsiveness is normalized by in vitro treatment with histone deacetylase inhibitors (HDACi). The present study examined the effect of a systemically administered HDACi, suberanilohydroxamic acid (SAHA) on GABA sensitivity, and related molecular changes in VTA neurons during withdrawal after chronic EtOH intake in rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acer.13870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214766PMC
November 2018
2 Reads

Insights into the long-term persistence of Legionella in facilities from whole-genome sequencing.

Infect Genet Evol 2018 Nov 31;65:200-209. Epub 2018 Jul 31.

Wadsworth Center, New York State Department of Health, 120 New Scotland Ave., Albany, NY 12208, USA.

We investigated the value of whole-genome sequencing (WGS) and single nucleotide polymorphism (SNP) analyses in determining the relationships among and evolutionary rates of Legionella species with long-term persistence in three healthcare facilities. We examined retrospective clinical and environmental isolates of Legionella micdadei and Legionella pneumophila serogroup 1 isolates with identical PFGE DNA fingerprints sampled over the course of up to 18 years. WGS analyses demonstrated that heterogeneous populations of Legionella were present within each facility despite displaying the same PFGE profiles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2018.07.040DOI Listing
November 2018

Retinal nerve fiber layer thickness after laser-assisted subepithelial keratomileusis and femtosecond LASIK: a prospective observational cohort study.

Clin Ophthalmol 2018 4;12:1213-1218. Epub 2018 Jul 4.

Clínica Novovisión, Madrid, Spain,

Purpose: Based on the assumption that high levels of intraocular pressure (IOP) during femtosecond laser-assisted in situ keratomileusis (FS-LASIK) may compromise the retinal nerve fiber layer (RNFL), newer femtosecond platforms that operate without causing significant IOP elevation have been developed in recent years. However, this assumption has not been adequately tested. The aim of the current study was to evaluate possible changes in RFNL thickness in nonglaucomatous myopic patients undergoing FS-LASIK using the 60 KHz IntraLase device that significantly elevates the IOP for an appreciable period of time vs an advanced surface ablation technique (laser-assisted subepithelial keratomileusis, LASEK) that does not induce any IOP elevation. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/retinal-nerve-fiber-layer-thicknes
Publisher Site
http://dx.doi.org/10.2147/OPTH.S168033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038866PMC
July 2018
8 Reads

Laparoscopic splenectomy for immune thrombocytopenia in patients with a very low platelet count.

Wideochir Inne Tech Maloinwazyjne 2018 Jun 16;13(2):157-163. Epub 2018 May 16.

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Introduction: Laparoscopic splenectomy (LS) is the gold standard in treating immune thrombocytopenia (ITP). However, there are still some problems in decision-making when considering LS in patients with a very low platelet count (PLT).

Aim: To evaluate safety outcomes of LS in patients with severe ITP and very low PLT in comparison to those with higher PLT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/wiitm.2018.75847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041578PMC
June 2018
2 Reads

Commentary on "Intraocular Pressure After LASEK".

Graefes Arch Clin Exp Ophthalmol 2018 Jun 20. Epub 2018 Jun 20.

Novovision, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-018-4048-zDOI Listing
June 2018
1 Read

Intraocular pressure after LASEK.

Graefes Arch Clin Exp Ophthalmol 2018 Jun 20. Epub 2018 Jun 20.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via Salvador Allende, 84081, Baronissi, Salerno, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-018-4047-0DOI Listing

Preoperative refraction, age and optical zone as predictors of optical and visual quality after advanced surface ablation in patients with high myopia: a cross-sectional study.

BMJ Open 2018 Jun 4;8(6):e023877. Epub 2018 Jun 4.

Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China.

Objective: To investigate the factors associated with optical and visual quality of advanced surface ablation in high myopia.

Design: A cross-sectional study of high myopic eyes treated with laser epithelial keratomileusis (LASEK)/epipolis laser in situ keratomileusis (Epi-LASIK). SETTING6: Eye and ENT Hospital of Fudan University in Shanghai. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988164PMC
June 2018
3 Reads

Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol.

Neuropharmacology 2018 07 9;137:86-95. Epub 2018 May 9.

Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain. Electronic address:

Pleiotrophin (PTN) and Midkine (MK) are neurotrophic factors that are upregulated in the prefrontal cortex after alcohol administration and have been shown to reduce ethanol drinking and reward. PTN and MK are the endogenous inhibitors of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ (a.k. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2018.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050104PMC
July 2018
5 Reads

Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries in the early period after trauma.

Cent Eur J Immunol 2018 30;43(1):42-49. Epub 2018 Mar 30.

2nd Department of Orthopaedics and Kinetic Organ Traumatology, Medical University of Gdańsk, Poland.

Introduction: Severe trauma causes damage to the protective barriers of the organism, and thus activates immunological reaction. Among substances secreted during this process pro-inflammatory cytokines are of high importance.

The Aim Of The Study: Severe trauma causing multiple injuries is more likely to lead to particularly intensive inflammatory reaction, which can sometimes lead to serious complications, even life-threatening. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/ceji.2018.74872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927172PMC
March 2018
1 Read

Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.

Psychoneuroendocrinology 2018 Jun 27;92:13-20. Epub 2018 Mar 27.

Center for Alcohol Research in Epigenetics and Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612 USA. Electronic address:

The LIM domain only protein LMO3 is a transcriptional regulator that has been shown to regulate several behavioral responses to alcohol. Specifically, Lmo3 null (Lmo3) mice consume more ethanol in a binge-drinking test and show enhanced ethanol-induced sedation. Due to the high comorbidity of alcohol use and anxiety, we investigated anxiety-like behavior in Lmo3 mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psyneuen.2018.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924609PMC

Transcriptional Regulators as Targets for Alcohol Pharmacotherapies.

Handb Exp Pharmacol 2018 ;248:505-533

Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.

Alcohol use disorder (AUD) is a chronic relapsing brain disease that currently afflicts over 15 million adults in the United States. Despite its prevalence, there are only three FDA-approved medications for AUD treatment, all of which show limited efficacy. Because of their ability to alter expression of a large number of genes, often with great cell-type and brain-region specificity, transcription factors and epigenetic modifiers serve as promising new targets for the development of AUD treatments aimed at the neural circuitry that underlies chronic alcohol abuse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/164_2018_101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242703PMC
January 2018
1 Read

Keratectasia after laser-assisted subepithelial keratectomy for myopia: A case report.

Medicine (Baltimore) 2018 Mar;97(12):e0094

Rationale: Recently, some ophthalmologists performed PRK or LASEK surgeries in FFKC suspicious patients, which is supposed to prevent FFKC evolvement via fibrotic scar formation. Our report indicates that keratectasia can occur after LASEK in FFKC suspicious patients, highlighting the importance of stricter regulation of patient recruitment before the procedure and postoperative follow-up.

Patient Concerns: This is a report of a 25-year-old man with poor corrected distance visual acuity (CDVA) 6 years after LASEK. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000010094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895349PMC
March 2018
2 Reads

Callitriche cophocarpa biomass as a potential low-cost biosorbent for trivalent chromium.

J Environ Manage 2018 May 10;214:295-304. Epub 2018 Mar 10.

Wroclaw University of Economics, Department of Industrial Chemistry, Komandorska 118/120 St., 53-345, Wrocław, Poland. Electronic address:

The present study focused on the use of the dry mass of the macrophyte Callitriche cophocarpa as an effective biosorbent for chromium removal from concentrated solutions, typical for industrial effluents. In order to evaluate the usability of C. cophocarpa as the Cr(III) sorbent, its detailed physicochemical characterization has been performed as well as the preliminary adsorption studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2018.03.010DOI Listing

20 years' experience with laparoscopic splenectomy. Single center outcomes of a cohort study of 500 cases.

Int J Surg 2018 Apr 23;52:285-292. Epub 2018 Feb 23.

2nd Department of General Surgery, Jagiellonian University Medical College, Kopernika 21 St., 31-501, Kraków, Poland; Centre for Research, Training and Innovation in Surgery (CERTAIN Surgery), Krakow, Poland. Electronic address:

Background: Laparoscopic splenectomy (LS) has become the gold standard in elective spleen surgery. Although it is considered relatively safe, treatment results vary depending on a hospital's profile and the experience of the surgeon and center. We would like to present experience of a high-volume referral center with minimally invasive operations of the spleen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijsu.2018.02.042DOI Listing
April 2018
1 Read

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study.

Authors:

Lancet Infect Dis 2018 May 13;18(5):516-525. Epub 2018 Feb 13.

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.

Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(18)30101-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910057PMC
May 2018
25 Reads
3 Citations
22.433 Impact Factor

Synergistic antitumor effects of histone deacetylase inhibitor scriptaid and bortezomib against ovarian cancer cells.

Oncol Rep 2018 Apr 6;39(4):1999-2005. Epub 2018 Feb 6.

Department of Immunology, Centre of Biostructure Research, Medical University of Warsaw, 02-097 Warsaw, Poland.

Despite debulking surgery and good initial response to chemotherapy, the majority of patients with advanced ovarian cancer relapse and succumb to their disease. Thus, there is a pressing need to improve treatment outcome. In the present study, the antitumor activity of histone deacetylase (HDAC) inhibitor scriptaid in combination with bortezomib or conventional chemotherapeutics was tested in vitro against representative ovarian cancer cell lines: SKOV‑3, MDAH 2774, and OVP‑10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2018.6248DOI Listing
April 2018
1 Read

Utility of Goldmann applanation tonometry for monitoring intraocular pressure in glaucoma patients with a history of laser refractory surgery.

PLoS One 2018 5;13(2):e0192344. Epub 2018 Feb 5.

Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.

The utility of Goldmann applanation tonometry (GAT) for monitoring intraocular pressure (IOP) in open-angle glaucoma (OAG) patients with a history of laser refractive surgery was investigated by comparing IOP fluctuations measured using GAT and dynamic contour tonometry (DCT) on the same day. In this retrospective study, patients were divided into one of two subgroups according to IOP fluctuation values using GAT: 43 eyes in the low IOP fluctuation group (LIFG [GAT fluctuation ≤1.7 mmHg]); and 55 eyes in the high IOP fluctuation group (HIFG [GAT fluctuation >1. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192344PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798809PMC
April 2018
2 Reads

Investigation of the Changes in Refractive Surgery Trends in Korea.

Korean J Ophthalmol 2018 02 25;32(1):8-15. Epub 2018 Jan 25.

Yeonsu Kim's Eye Clinic, Incheon, Korea.

Purpose: To evaluate changes in clinical practice in the field of refractive surgery in Korea over the past 10 years.

Methods: A survey consisting of 59 multiple-choice questions regarding the preferred types of refractive surgery, excimer laser machine, and presbyopia surgery was mailed to 742 members of the Korean Society of Cataract and Refractive Surgery in January 2016, and 50 members responded to the survey. These data were compared with the 2005 or 2007 survey results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3341/kjo.2017.0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801094PMC
February 2018
3 Reads

Estradiol enhances ethanol reward in female mice through activation of ERα and ERβ.

Horm Behav 2018 02 9;98:159-164. Epub 2018 Feb 9.

Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC 912, Chicago, IL 60612, United States. Electronic address:

Alcohol use disorder (AUD) manifests differently in men and women, but little is known about sex differences in the brain's response to ethanol. It is known that the steroid hormone 17β-estradiol (E2) regulates voluntary ethanol consumption in female rodents. However, the role of E2 as a regulator of ethanol reward has not been investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yhbeh.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829002PMC
February 2018
9 Reads

Estrogen Receptor β in the Nucleus Accumbens Regulates the Rewarding Properties of Cocaine in Female Mice.

Int J Neuropsychopharmacol 2018 Apr;21(4):382-392

Department of Psychiatry, University of Illinois at Chicago, Chicago, IL.

Background: Females are more vulnerable to developing cocaine addiction compared with males, a phenomenon that may be regulated by the steroid hormone 17β-estradiol. 17β-Estradiol enhances cocaine reward as measured by the conditioned place preference test. It is currently not known which estrogen receptor is involved or the neuroanatomical locations in which estrogen receptors act to enhance cocaine responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ijnp/pyx118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887286PMC
April 2018
3 Reads

Releasing Addiction Memories Trapped in Perineuronal Nets.

Trends Genet 2018 03 27;34(3):197-208. Epub 2017 Dec 27.

Center for Alcohol Research in Epigenetics and Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA.

Drug addiction can be conceptualized at a basic level as maladaptive learning and memory. Addictive substances elicit changes in brain circuitry involved in reward, cognition, and emotional state, leading to the formation and persistence of strong drug-associated memories that lead to craving and relapse. Recently, perineuronal nets (PNNs), extracellular matrix (ECM) structures surrounding neurons, have emerged as regulators of learning, memory, and addiction behaviors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tig.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834377PMC
March 2018
6 Reads

Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders.

Eur J Med Chem 2018 Jan 28;144:318-329. Epub 2017 Nov 28.

Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain. Electronic address:

A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These compounds exert their action by interacting with the intracellular domain PD1 of the Protein Tyrosine-Phosphatase Receptor Z1 (PTPRZ1), and inhibiting its tyrosine phosphatase activity. The most potent compounds 10a and 12b (IC = 0,1 μM) significantly increase the phosphorylation of key tyrosine residues of PTPRZ1 substrates involved in neuronal survival and differentiation, and display protective effects against amphetamine-induced toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2017.11.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817915PMC
January 2018
43 Reads

Studying Sex Differences in Animal Models of Addiction: An Emphasis on Alcohol-Related Behaviors.

ACS Chem Neurosci 2018 Aug 26;9(8):1907-1916. Epub 2017 Dec 26.

Animal models are essential for understanding the biological factors that contribute to drug and alcohol addiction and discovering new pharmacotherapies to treat these disorders. Alcohol (ethanol) is the most commonly abused drug in the world, and as the prevalence of alcohol use disorder (AUD) increases, so does the need for effective pharmacotherapies. In particular, treatments with high efficacy in the growing number of female AUD sufferers are needed. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acschemneuro.7b00449
Publisher Site
http://dx.doi.org/10.1021/acschemneuro.7b00449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019619PMC
August 2018
4 Reads

Long-term Follow-up of LASEK With Mitomycin C Performed to Correct Myopia in Thin Corneas.

J Refract Surg 2017 Dec;33(12):813-819

Purpose: To evaluate the long-term outcomes of laser-assisted subepithelial keratomileusis (LASEK) with intraoperative use of mitomycin C (MMC) performed on thin corneas for the correction of myopia.

Methods: This retrospective cohort study included 100 eyes with a preoperative central corneal thickness (CCT) thinner than 500 μm that underwent LASEK + MMC with at least 6 years of follow-up. Stability of visual acuity and refraction and the efficacy, safety, and predictability at the examinations 3 months and the last annual postoperative visit were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3928/1081597X-20171004-06DOI Listing
December 2017
12 Reads

Demarcation Line in the Human Cornea After Surface Ablation Observed by Optical Coherence Tomography and Confocal Microscopy.

Eye Contact Lens 2018 Nov;44 Suppl 2:S19-S23

Department of Ophthalmology (M.L., Y.Z., P.Y., M.P., L.S., and X.Z.), Key Lab of Myopia, Ministry of Health, EYE and ENT Hospital of Fudan University, Shanghai, China; and Department of Optometry (Q.X.), Neweye Hospital, Shanghai, China.

Purpose: To investigate the long-term changes in anterior corneal structure after surface ablation.

Methods: In this retrospective study, patients who received surface ablation including laser-assisted subepithelial keratomileusis (LASEK) and epipolis laser in situ keratomileusis at the Department of Ophthalmology of Fudan University Eye and Ear, Nose and Throat (EENT) Hospital (Shanghai, People's Republic of China) were telephoned. Patients were asked to follow-up at the refractive center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICL.0000000000000459DOI Listing
November 2018
6 Reads

Ovarian Hormones Contribute to High Levels of Binge-Like Drinking by Female Mice.

Alcohol Clin Exp Res 2018 Feb 8;42(2):286-294. Epub 2018 Jan 8.

Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.

Background: Recently, the incidence of binge drinking by women has increased. Binge drinking is detrimental to women's health, yet the biological mechanisms that promote excessive drinking by women are not well understood. One method of assessing binge-like ethanol (EtOH) consumption in mice is the drinking in the dark (DID) test, in which mice drink sufficient EtOH to achieve intoxication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acer.13571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785425PMC
February 2018
2 Reads

Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol.

PLoS One 2017 6;12(11):e0187698. Epub 2017 Nov 6.

Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, United States of America.

Gender differences in psychiatric disorders such as addiction may be modulated by the steroid hormone estrogen. For instance, 17β-estradiol (E2), the predominant form of circulating estrogen in pre-menopausal females, increases ethanol consumption, suggesting that E2 may affect the rewarding properties of ethanol and thus the development of alcohol use disorder in females. The ventral tegmental area (VTA) is critically involved in the rewarding and reinforcing effects of ethanol. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187698PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673180PMC
November 2017
12 Reads

Influence of LASEK on Schiøtz, Goldmann and dynamic contour Tonometry.

Graefes Arch Clin Exp Ophthalmol 2018 Jan 14;256(1):173-179. Epub 2017 Oct 14.

Novovision Madrid, Madrid, Spain.

Purpose: Our purpose was to assess the effect of LASEK surgery on ocular rigidity and to compare its effect on intraocular pressure (IOP) readings with Goldmann applanation tonometry (GAT), Schiøtz indentation tonometry (ST) and dynamic contour tonometry (DCT).

Methods: Prospective, observational, single-masked cohort study. One eye per patient from 31 consecutive subjects who underwent LASEK refractive surgery to correct myopia, as well as from 108 non-operated myopic patients, were included. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00417-017-3825-4
Publisher Site
http://dx.doi.org/10.1007/s00417-017-3825-4DOI Listing
January 2018
7 Reads

[A case of reactive arthritis (oculo-urethro-synovial syndrome) treated with infliximab].

Ann Dermatol Venereol 2017 Dec 19;144(12):804-805. Epub 2017 Sep 19.

Service de dermatologie, hôpital Saint-Vincent, université catholique, BP 387, boulevard de Belfort, 59000 Lille, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.annder.2017.08.004DOI Listing
December 2017
1 Read

The best of the best: a review of select glaucoma case reports published in 2015.

Digit J Ophthalmol 2016 31;22(4):75-78. Epub 2016 Dec 31.

Massachusetts Eye and Ear Infirmary, Harvard Medical School.

This review article summarizes four key case reports published in the field of glaucoma in the year 2015. The first article describes a novel technique for draining choroidal fluid in patients with uveal effusion syndrome. The second article describes 2 cases of recurrent vitreous block despite adequate surgical intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5693/djo.01.2016.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596907PMC
December 2017
8 Reads

Genome content, metabolic pathways and biotechnological potential of the psychrophilic Arctic bacterium Psychrobacter sp. DAB_AL43B, a source and a host of novel Psychrobacter-specific vectors.

J Biotechnol 2017 Dec 15;263:64-74. Epub 2017 Sep 15.

Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.

Psychrobacter sp. DAB_AL43B, isolated from ornithogenic soil collected on the Arctic island of Spitsbergen, is a newly sequenced psychrophilic strain susceptible to conjugation and electrotransformation. Its genome consists of a circular chromosome (3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiotec.2017.09.011DOI Listing
December 2017
101 Reads

A Multicenter Retrospective Survey of Refractive Surgery in 78,248 Eyes.

J Refract Surg 2017 Sep;33(9):598-602

Purpose: To retrospectively evaluate the current practice, trends, and outcomes of refractive surgery in Japan.

Methods: This multicenter survey comprised 78,248 eyes of 39,727 consecutive patients who underwent refractive surgery at 45 major institutions in Japan. The corresponding ophthalmologists responded to a selfadministered questionnaire. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3928/1081597X-20170621-01DOI Listing
September 2017
7 Reads

Anaplastic Lymphoma Kinase Is a Regulator of Alcohol Consumption and Excitatory Synaptic Plasticity in the Nucleus Accumbens Shell.

Front Pharmacol 2017 15;8:533. Epub 2017 Aug 15.

Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, AustinTX, United States.

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nucleus accumbens shell (NAcSh) medium spiny neurons (MSNs), and putative targets for treating AUD may be validated for further development by assessing how their manipulation modulates accumbal glutamatergic synaptic transmission and plasticity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2017.00533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559467PMC
August 2017
11 Reads

Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking.

Alcohol Clin Exp Res 2017 Nov 3;41(11):1896-1906. Epub 2017 Oct 3.

Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana.

Background: A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being associated with high alcohol drinking by alcohol-preferring (P) rats. The objectives of the current study were to characterize the effects of reduced levels of mGlu2 receptors on glutamate transmission and alcohol drinking.

Methods: Quantitative no-net-flux microdialysis was used to test the hypothesis that basal extracellular glutamate levels in the prelimbic (PL) cortex and nucleus accumbens shell (NACsh) will be higher in P than Wistar rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acer.13488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659915PMC
November 2017
2 Reads

Visual Outcomes After SMILE, LASEK, and LASEK Combined With Corneal Cross-Linking for High Myopic Correction.

Cornea 2017 11;36(11):e33

*Clínica Novovisión, Madrid, Spain †Clínica Rementería, Madrid, Spain ‡Hospital Universitario "Príncipe de Asturias," University of Alcalá, Alcalá de Henares, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICO.0000000000001355DOI Listing
November 2017
7 Reads