946 results match your criteria LASEK


Estrogen Receptor α Regulates Ethanol Excitation of Ventral Tegmental Area Neurons and Binge Drinking in Female Mice.

J Neurosci 2020 Jun 1. Epub 2020 Jun 1.

Center for Alcohol Research in Epigenetics and Department of Psychiatry, University of Illinois at Chicago

Elevations in estrogen (17β-estradiol, E2) are associated with increased alcohol drinking by women and experimentally in rodents. E2 alters the activity of the dopamine system, including the ventral tegmental area (VTA) and its projection targets, which plays an important role in binge drinking. A previous study demonstrated that during high E2 states, VTA neurons in female mice are more sensitive to ethanol excitation. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2364-19.2020DOI Listing

Nutrient Content of Different Wheat and Maize Varieties and Their Impact on Metabolizable Energy Content and Nitrogen Utilization by Broilers.

Animals (Basel) 2020 May 23;10(5). Epub 2020 May 23.

Department of Animal Nutrition and Biotechnology, and Fisheries, Agricultural University of Krakow, Al. Mickiewicza 24/28, 30-059 Krakow, Poland.

The study aimed to determine the effect of nutrients of wheat (nine cultivars) and maize (nine cultivars) grain on nitrogen balance and apparent metabolizable energy (AME) content for broiler chickens. In vivo digestibility and balance trials were carried out with 90 Ross 308 chickens (2 × 9 groups with 5 birds per group) aged from 42 to 49 days, separately for each cultivar. Considerable variation within each cereal species in fiber and non-fiber carbohydrate fractions and nutrient digestibility of grain were demonstrated. Read More

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http://dx.doi.org/10.3390/ani10050907DOI Listing

Laser-assisted subepithelial keratomileusis substituted for an aborted small-incision lenticule extraction due to large black area formation.

J Cataract Refract Surg 2020 Mar 20. Epub 2020 Mar 20.

Department of Ophthalmology, Peking University Third Hospital, Beijing, China.

A 25-year-old woman with moderate myopia presented for refractive surgery. Bilateral femtosecond laser small-incision lenticule extraction (SMILE) was scheduled and her right eye was completed smoothly. However, during the lenticule cutting of her left eye, a large inferior black area was noted. Read More

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http://dx.doi.org/10.1097/j.jcrs.0000000000000185DOI Listing

[Transitory apocrine hidrocystomatosis of the scrotum].

Ann Dermatol Venereol 2020 May 9;147(5):361-365. Epub 2020 Mar 9.

Service de dermatologie, grand hôpital de Charleroi, rue de Villers 1, 6280 Loverval, Belgique.

Background: Apocrine hidrocystomas are benign cystic tumors that develop from apocrine gland proliferation. In most cases, they are translucent solitary lesions of the face, generally found in the periorbital region, on the scalp or on the neck. More rarely, apocrine hidrocystomas may be multiple and appear on the ears, trunk, shoulders and genital area. Read More

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http://dx.doi.org/10.1016/j.annder.2019.09.610DOI Listing

Comparison of Higher-Order Aberrations after LASEK between Two Different Laser Platforms for Low-to-Moderate Myopia.

Curr Eye Res 2020 Feb 23:1-7. Epub 2020 Feb 23.

Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, P.R. China.

: To compare the differences in higher-order aberrations (HOAs) after laser subepithelial keratomileusis (LASEK) between two different laser platforms.: One hundred and seven eyes of 107 patients were included in this study. Fifty-six eyes underwent LASEK with the Triple-A profile (an ablation profile of the MEL 90 excimer laser) and 51 eyes underwent LASEK with the aspheric (Aberration Smart Ablation [ASA]) profile. Read More

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http://dx.doi.org/10.1080/02713683.2020.1726404DOI Listing
February 2020

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection.

Authors:

BJS Open 2019 Jun 28;3(3):403-414. Epub 2019 Feb 28.

Background: End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.

Methods: This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Read More

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http://dx.doi.org/10.1002/bjs5.50138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921967PMC

Predictors of Myopic Regression for Laser-assisted Subepithelial Keratomileusis and Laser-assisted in Situ Keratomileusis Flap Creation with Mechanical Microkeratome and Femtosecond Laser in Low and Moderate Myopia.

Ophthalmic Epidemiol 2020 Jun 26;27(3):177-185. Epub 2019 Dec 26.

School of Public Health, Capital Medical University, Beijing, China.

: To determine the predictive factors of postoperative myopic regression in subjects who have undergone laser-assisted subepithelial keratomileusis (LASEK), laser-assisted in situ keratomileusis (LASIK) with flaps created using a mechanical microkeratome (MM) or LASIK with flaps created using a femtosecond (FS) laser for -0.50 D to -6.0 D myopia. Read More

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http://dx.doi.org/10.1080/09286586.2019.1704793DOI Listing

[Clinical study on topography-guided laser ablation combined with accelerated corneal collagen cross-linking for early keratoconus].

Zhonghua Yan Ke Za Zhi 2019 Dec;55(12):904-910

Department of ophthalmology, Peking University Third Hospital, Beijing 100191, China; 2 Department of ophthalmology, The Second Hospital of Zhengzhou. Zhengzhou 450006, Henan, China.

To study the safety and efficacy of topography-guided customized excimer laser subepithelial ablation combined with accelerated collagen cross-linking technique in treatment of early keratoconus. Ninteen patients(20 eyes) (13 males 14 eyes, and 6 females 6 eyes), aged 12 to 44 years (24.7±8. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.12.007DOI Listing
December 2019

Comparing Dry Eye Disease After Small Incision Lenticule Extraction and Laser Subepithelial Keratomileusis.

Cornea 2020 Apr;39(4):501-507

Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.

Purpose: To compare dry eye disease parameters between small incision lenticule extraction (SMILE) and laser subepithelial keratomileusis (LASEK).

Methods: This prospective, nonrandomized study included 39 eyes of 39 patients who underwent SMILE (n = 19) and LASEK (n = 20). Dry eye disease parameters included Ocular Surface Disease Index (OSDI), tear breakup time, Schirmer I test (SIT) value, corneal esthesiometry result, tear meniscus area, meibomian gland evaluation result, lipid layer thickness, and blink rate. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002240DOI Listing

Inactivation of Genes Encoding MutL and MutS Proteins Influences Adhesion and Biofilm Formation by .

Microorganisms 2019 Dec 4;7(12). Epub 2019 Dec 4.

Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.

is an etiological agent of gonorrhea, which remains a global health problem. This bacterium possesses MutL and MutS DNA repair proteins encoded by and genes, whose inactivation causes a mutator phenotype. We have demonstrated the differential gene expression in and mutants using DNA microarrays. Read More

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http://dx.doi.org/10.3390/microorganisms7120647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955733PMC
December 2019

Author Correction: Risk factors for serious morbidity, prolonged length of stay and hospital readmission after laparoscopic appendectomy - results from Pol-LA (Polish Laparoscopic Appendectomy) multicenter large cohort study.

Sci Rep 2019 Dec 6;9(1):18479. Epub 2019 Dec 6.

2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-54993-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897885PMC
December 2019

Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer.

J Med Chem 2019 12 10;62(24):11301-11323. Epub 2019 Dec 10.

Department of Psychiatry , University of Illinois at Chicago , 1601 W Taylor Street , Chicago , Illinois 60612 , United States.

The clinical steroidal selective estrogen receptor (ER) degrader (SERD), fulvestrant, is effective in metastatic breast cancer, but limited by poor pharmacokinetics, prompting the development of orally bioavailable, nonsteroidal SERDs, currently in clinical trials. These trials address local breast cancer as well as peripheral metastases, but patients with brain metastases are generally excluded because of the lack of blood-brain barrier penetration. A novel family of benzothiophene SERDs with a basic amino side arm (B-SERDs) was synthesized. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b01580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261373PMC
December 2019

Anaplastic Lymphoma Kinase Regulates Internalization of the Dopamine D2 Receptor.

Mol Pharmacol 2020 02 16;97(2):123-131. Epub 2019 Nov 16.

Center for Alcohol Research in Epigenetics and Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois

The dopamine D2 receptor (D2R) is a G protein-coupled receptor (GPCR) expressed in regions of the brain that control motor function, cognition, and motivation. As a result, D2R is involved in the pathophysiology of disorders such as schizophrenia and drug addiction. Understanding the signaling pathways activated by D2R is crucial to finding new therapeutic targets for these disorders. Read More

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http://dx.doi.org/10.1124/mol.119.117473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964149PMC
February 2020

Corneal Ectasia Risk And Percentage Tissue Altered In Myopic Patients Presenting For Refractive Surgery.

Clin Ophthalmol 2019 14;13:2003-2015. Epub 2019 Oct 14.

Department of Corneal and External Diseases, Singapore National Eye Centre, Singapore, Singapore.

Purpose: A percentage tissue altered (PTA) score of ≥40% has been advocated as an independent indicator of post-operative ectasia risk following laser in-situ keratomileusis (LASIK). This study was performed to test the hypothesis that refractive procedures, such as laser-assisted sub-epithelial keratectomy (LASEK) or small incision lenticule extraction (SMILE), may alter the range of PTA, within which refractive corneal surgery can be safely performed.

Setting: Refractive department, tertiary ophthalmic hospital. Read More

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http://dx.doi.org/10.2147/OPTH.S215144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798818PMC
October 2019

Receptor Tyrosine Kinases as Therapeutic Targets for Alcohol Use Disorder.

Neurotherapeutics 2020 01;17(1):4-16

Department of Psychiatry and Center for Alcohol Research in Epigenetics, University of Illinois at Chicago, 1601 West Taylor Street, MC 912, Chicago, Illinois, 60612, USA.

The receptor tyrosine kinases (RTKs) are a large family of proteins that transduce extracellular signals to the inside of the cell to ultimately affect important cellular functions such as cell proliferation, survival, apoptosis, differentiation, and migration. They are expressed in the nervous system and can regulate behavior through modulation of neuronal and glial function. As a result, RTKs are implicated in neurodegenerative and psychiatric disorders such as depression and addiction. Read More

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http://dx.doi.org/10.1007/s13311-019-00795-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007457PMC
January 2020

Risk factors for serious morbidity, prolonged length of stay and hospital readmission after laparoscopic appendectomy - results from Pol-LA (Polish Laparoscopic Appendectomy) multicenter large cohort study.

Sci Rep 2019 10 15;9(1):14793. Epub 2019 Oct 15.

2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Laparoscopic appendectomy (LA) for treatment of acute appendicitis has gained acceptance with its considerable benefits over open appendectomy. LA, however, can involve some adverse outcomes: morbidity, prolonged length of hospital stay (LOS) and hospital readmission. Identification of predictive factors may help to identify and tailor treatment for patients with higher risk of these adverse events. Read More

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http://dx.doi.org/10.1038/s41598-019-51172-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794313PMC
October 2019
1 Read

Myopic Laser-Assisted Subepithelial Keratectomy (LASEK) outcomes using three different excimer laser platforms: a retrospective observational study.

BMC Ophthalmol 2019 Oct 15;19(1):205. Epub 2019 Oct 15.

Clínica Novovisión Madrid, Paseo de la Castellana 54, 28046, Madrid, Spain.

Background: To compare the visual and refractive outcomes after myopic LASEK using three different excimer lasers and standardized surgical and mitomycin C (MMC) application protocols.

Methods: In this retrospective, observational cohort study, we examined 122 eyes treated with Allegretto, 135 eyes treated with Esiris and 137 eyes treated with Technolas excimer lasers. All eyes were treated under the same surgical protocol, and a standardized MMC dosage was used. Read More

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http://dx.doi.org/10.1186/s12886-019-1214-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792330PMC
October 2019
1 Read

Predictors affecting myopic regression in - 6.0D to - 10.0D myopia after laser-assisted subepithelial keratomileusis and laser in situ keratomileusis flap creation with femtosecond laser-assisted or mechanical microkeratome-assisted.

Int Ophthalmol 2020 Jan 30;40(1):213-225. Epub 2019 Sep 30.

School of Public Health, Capital Medical University, Beijing, China.

Purpose: To investigate the predictive factors of postoperative myopic regression among subjects who have undergone laser-assisted subepithelial keratomileusis (LASEK), laser-assisted in situ keratomileusis (LASIK) flap created with a mechanical microkeratome (MM), and LASIK flap created with a femtosecond laser (FS). All recruited patients had a manifest spherical equivalence (SE) from - 6.0D to - 10. Read More

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http://dx.doi.org/10.1007/s10792-019-01179-5DOI Listing
January 2020
6 Reads

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol.

J Proteome Res 2019 11 2;18(11):3999-4012. Epub 2019 Oct 2.

Department of Psychiatry , University of Illinois at Chicago , 1601 West Taylor Street , Chicago , Illinois 60612 , United States.

Cocaine addiction afflicts nearly 1 million adults in the United States, and to date, there are no known treatments approved for this psychiatric condition. Women are particularly vulnerable to developing a cocaine use disorder and suffer from more serious cardiac consequences than men when using cocaine. Estrogen is one biological factor contributing to the increased risk for females to develop problematic cocaine use. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917473PMC
November 2019
4 Reads
4.245 Impact Factor

Scurvy presenting as pseudo-scleroderma of the leg.

JAAD Case Rep 2019 Sep 3;5(9):831-833. Epub 2019 Sep 3.

Dermatology Department, Hôpital Saint Vincent de Paul, Université Catholique de Lille, Lille, France.

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http://dx.doi.org/10.1016/j.jdcr.2019.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731345PMC
September 2019
3 Reads

Perineuronal nets in the insula regulate aversion-resistant alcohol drinking.

Authors:
Hu Chen Amy W Lasek

Addict Biol 2019 Aug 21:e12821. Epub 2019 Aug 21.

Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.

One of the most pernicious characteristics of alcohol use disorder is the compulsion to drink despite negative consequences. The insular cortex controls decision making under conditions of risk or conflict. Cortical activity is tightly controlled by inhibitory interneurons that are often enclosed by specialized extracellular matrix structures known as perineuronal nets (PNNs), which regulate neuronal excitability and plasticity. Read More

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http://dx.doi.org/10.1111/adb.12821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032993PMC
August 2019
3 Reads

Monolayer Modification of VTe and Its Charge Density Wave.

J Phys Chem Lett 2019 Sep 15;10(17):4987-4993. Epub 2019 Aug 15.

Department of Physics, University of South Florida, Tampa, Florida 33620, United States.

Interlayer interactions in layered transition metal dichalcogenides are known to be important for describing their electronic properties. Here, we demonstrate that the absence of interlayer coupling in monolayer VTe also causes their structural modification from a distorted 1T' structure in bulk and multilayer samples to a hexagonal 1T structure in the monolayer. X-ray photoemission spectroscopy indicates that this structural transition is associated with electron transfer from the vanadium d bands to the tellurium atoms for the monolayer. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b01949DOI Listing
September 2019
3 Reads

Corneal biomechanical properties after SMILE versus FLEX, LASIK, LASEK, or PRK: a systematic review and meta-analysis.

BMC Ophthalmol 2019 Aug 1;19(1):167. Epub 2019 Aug 1.

Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Background: The aim of this study was to compare the postoperative corneal biomechanical properties between small incision lenticule extraction (SMILE) and other corneal refractive surgeries.

Methods: A systematic review and meta-analysis were conducted. Articles from January 2005, to April 2019, were identified searching PubMed, EMBASE, Web of Science, and International Clinical Trials Registry Platform. Read More

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http://dx.doi.org/10.1186/s12886-019-1165-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676534PMC
August 2019
9 Reads

Factors Affecting Myopic Regression after Laser in Situ Keratomileusis and Laser-Assisted Subepithelial Keratectomy for High Myopia.

Semin Ophthalmol 2019 1;34(5):359-364. Epub 2019 Jul 1.

a Refractive Surgery Department, Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences , Jinan , China.

To evaluate the factors affecting the amount of myopic regression after laser refractive surgery for high myopia, we retrospectively reviewed medical records of 1591 eyes with high myopia treated by laser in situ keratomileusis or laser-assisted subepithelial keratectomy at Shandong Eye Hospital between January 2008 and December 2012. Thirty-five eyes suffering a postoperative myopic shift of manifest spherical equivalent (MSE) of 0.25 diopter (D) or greater were included in this study. Read More

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http://dx.doi.org/10.1080/08820538.2019.1632353DOI Listing
August 2019
3 Reads

Ocular Surface Diseases Induced by Dupilumab in Severe Atopic Dermatitis.

Ophthalmol Ther 2019 Sep 22;8(3):485-490. Epub 2019 Jun 22.

Ophthalmology Department, Saint-Vincent de Paul Hospital, Boulevard de Belfort, Lille Cedex, France.

We report 10 cases of conjunctivitis in atopic dermatitis (AD) patients treated with dupilumab from November 2017 to November 2018 in our institution, who were referred to the ophthalmology department for diagnosis and management of conjunctivitis. We also describe ocular surface findings in these patients before the first injection of dupilumab. During the first 6 months post initiation of dupilumab, incidence of conjunctivitis was 27% (5/18) in patients treated from November 2017 to April 2018 who had not had ocular examination previously. Read More

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http://dx.doi.org/10.1007/s40123-019-0191-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692787PMC
September 2019
30 Reads

Evaluation of Children with Psoriasis from the BiPe Cohort: Are Patients Using Biotherapies in Real Life Eligible for Phase III Clinical Studies?

Paediatr Drugs 2019 Jun;21(3):169-175

Service de Dermatologie, Hôpital Victor Dupouy, 69 rue du Lieutenant-Colonel Prud'hon, 95100, Argenteuil, France.

Background: Phase III clinical trials of biotherapies for childhood psoriasis are designed for a selected population, which can differ from real-life patients.

Objective: Our objective was to assess the proportion of children with psoriasis that received biotherapy in the biological treatments for pediatric psoriasis (BiPe) cohort that would be excluded from phase III clinical trials of these treatments.

Methods: Data concerning initiation of the first biotherapy from all patients included in the BiPe cohort were analyzed. Read More

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http://dx.doi.org/10.1007/s40272-019-00335-9DOI Listing
June 2019
28 Reads

Short-term outcomes of combined pars plana vitrectomy for epiretinal membrane and phacoemulsification surgery with multifocal intraocular lens implantation.

Clin Ophthalmol 2019 23;13:723-730. Epub 2019 Apr 23.

Department of Ophthalmology, University of Cincinnati, Cincinnati, OH, USA,

Purpose: The purpose of this study was to evaluate the functional and anatomical outcomes of combined phacovitrectomy with multifocal intraocular lens (mfIOL) implantation.

Methods: Retrospective, interventional, non-comparative case series of six eyes that received a combined phacoemulsification surgery with apodized, diffractive mfIOL implantation for cataract and pars plana vitrectomy (PPV) with membrane peeling for epiretinal membrane (ERM). Outcome measures included distance and near visual acuities (DVA and NVA), central macular thickness (CMT), intraocular pressure (IOP), and disruption of external limiting membrane (ELM) or inner-segment outer-segment (IS/OS) junction. Read More

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http://dx.doi.org/10.2147/OPTH.S195928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485319PMC
April 2019
8 Reads

Clinical Evaluation of LASEK for High Myopia Correction between the Triple-A Profile and the Zyoptix Tissue Saving Profile.

J Ophthalmol 2019 1;2019:6936042. Epub 2019 Apr 1.

Department of Ophthalmology, Shanghai Tenth People's Hospital, No. 301 Middle Yanchang Road, Shanghai 200072, China.

Purpose: To compare the effects of correcting high myopia using the MEL®90 Triple-A profile LASEK at a 500 Hz pulse rate (Triple-A group) versus the Zyoptix tissue-saving ablations of Technolas 217z laser platform at 100 Hz (TS group).

Methods: This retrospective study included 50 eyes in the Triple-A group and 42 eyes in the TS group with manifest refraction spherical equivalent (MRSE) of -6 diopters (D) to -10 D. We compared uncorrected distance visual acuity, MRSE, corrected distance visual acuity, and postoperative complications at 1 month, 3 months, and 6 months. Read More

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http://dx.doi.org/10.1155/2019/6936042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466896PMC
April 2019
8 Reads

Prognostic Factors for Immune Thrombocytopenic Purpura Remission after Laparoscopic Splenectomy: A Cohort Study.

Medicina (Kaunas) 2019 Apr 18;55(4). Epub 2019 Apr 18.

2nd Department of General Surgery, Jagiellonian University Medical College, Kopernika 21,31-501 Kraków, Poland.

Background And Objectives: Laparoscopic splenectomy (LS) has become the gold standard for patients with immune thrombocytopenic purpura (ITP). The total remission rate after splenectomy is 70%-90%, of which 66% is long-term. Despite this high response rate, some patients do not benefit from surgery. Read More

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http://dx.doi.org/10.3390/medicina55040112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524013PMC
April 2019
6 Reads

COMBINED PHACOEMULSIFICATION SURGERY WITH MULTIFOCAL INTRAOCULAR LENS IMPLANTATION AND PARS PLANA VITRECTOMY FOR SYMPTOMATIC VITREOUS OPACITIES.

Retin Cases Brief Rep 2019 Apr 8. Epub 2019 Apr 8.

Cincinnati Eye Institute, Cincinnati, OH.

Purpose: To report surgical outcomes of combined vitrectomy for vitreous floaters and phacoemulsification surgery with multifocal intraocular lens implantation.

Methods: Retrospective, interventional, noncomparative case series of five eyes from five patients who underwent same-day combined phacoemulsification surgeries with apodized, diffractive multifocal intraocular lens implantation for cataract and pars plana vitrectomy for symptomatic vitreous opacities, that is, floaters. Primary outcomes were distance and near visual acuities, and resolution of symptoms. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000873DOI Listing
April 2019
3 Reads

Effect of age on visual and refractive results after laser-assisted subepithelial keratomileusis (LASEK) with adjuvant use of mitomycin C.

J Optom 2019 Apr - Jun;12(2):92-98. Epub 2019 Mar 18.

Clínica Novovisión Madrid, Madrid, Spain; Hospital Universitario "Príncipe de Asturias", University of Alcalá, Alcalá de Henares, Madrid, Spain.

Purpose: To evaluate the influence of age on visual and refractive results after laser-assisted subepithelial keratomileusis (LASEK) with the adjuvant use of mitomycin C (MMC) for the correction of myopia.

Methods: Retrospective, nonrandomized, cohort study. A total of 1374 eyes treated with LASEK+MMC were included in the study (we compared 1163 eyes of patients aged 18 to 40 years versus 211 eyes of patients over 40 years). Read More

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http://dx.doi.org/10.1016/j.optom.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449780PMC
April 2019
17 Reads

Comparative study of wave-front aberration and corneal Asphericity after SMILE and LASEK for myopia: a short and long term study.

BMC Ophthalmol 2019 Mar 20;19(1):80. Epub 2019 Mar 20.

Department of Ophthalmology, Eye and ENT Hospital, Fudan University, No. 83 Fenyang Road, Shanghai, 200031, China.

Background: The study compares the wave-front aberration and corneal asphericity from multiple perspectives after Small Incision Lenticule Extraction and Laser-assisted Subepithelial Keratomileusis for mild to moderate myopia in a short and long time period.

Methods: This prospective and comparative study included 32 eyes in the SMILE group, with a mean spherical equivalent (SE) of - 4.1 ± 0. Read More

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http://dx.doi.org/10.1186/s12886-019-1084-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425702PMC
March 2019
8 Reads

Complicated appendicitis: Risk factors and outcomes of laparoscopic appendectomy - Polish laparoscopic appendectomy results from a multicenter, large-cohort study.

Ulus Travma Acil Cerrahi Derg 2019 Mar;25(2):129-136

Polish Laparoscopic Appendectomy Collaborative Study Group.

Background: Preoperative classification of complicated and uncomplicated appendicitis (AA) is challenging. However, the differences in surgical outcomes necessitate the establishment of risk factors in developing, complicated AA. This study was an analysis of the clinical outcomes of laparoscopic appendectomies (LA), as well as preoperative risk factors for the development of complicated AA. Read More

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http://dx.doi.org/10.5505/tjtes.2018.80103DOI Listing
March 2019
9 Reads

Biological treatments for paediatric psoriasis : a retrospective observational study on biological drug survival in daily practice in childhood psoriasis.

J Eur Acad Dermatol Venereol 2019 Oct 15;33(10):1984-1992. Epub 2019 Apr 15.

Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France.

Background: Three biotherapies - etanercept, adalimumab and ustekinumab - are licensed in childhood psoriasis. The few data available on their efficacy and tolerance are mainly derived from industry trials. However, biological drug survival impacts long-term performance in real-life settings. Read More

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http://dx.doi.org/10.1111/jdv.15579DOI Listing
October 2019
4 Reads

A Critical Overview of the Biological Effects of Mitomycin C Application on the Cornea Following Refractive Surgery.

Adv Ther 2019 04 11;36(4):786-797. Epub 2019 Mar 11.

Clínica Novovisión, Madrid, Spain.

During the last 2 decades, modifying the shape of the cornea by means of laser photoablation has emerged as a successful and popular treatment option for refractive errors. Corneal surface ablation techniques such as photorefractive keratectomy (PRK) and laser-assisted subepithelial keratomileusis (LASEK) offer good refractive results while having a minimal impact on corneal biomechanical stability. Past limitations of these techniques included the long-term regression of refractive outcome and a vigorous healing response that reduced corneal clarity in some patients (giving rise to what is clinically described as "haze"). Read More

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http://dx.doi.org/10.1007/s12325-019-00905-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824355PMC
April 2019
4 Reads

The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol withdrawal.

Alcohol 2019 08 6;78:79-87. Epub 2019 Mar 6.

Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States. Electronic address:

Withdrawal from chronic alcohol drinking can cause depression, leading to an inability to function in daily life and an increased risk for relapse to harmful drinking. Understanding the causes of alcohol withdrawal-related depression may lead to new therapeutic targets for treatment. Epigenetic factors have recently emerged as important contributors to both depression and alcohol use disorder (AUD). Read More

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http://dx.doi.org/10.1016/j.alcohol.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612300PMC
August 2019
20 Reads

Effectiveness and safety of dupilumab for the treatment of atopic dermatitis in a real-life French multicenter adult cohort.

J Am Acad Dermatol 2019 Jul 27;81(1):143-151. Epub 2019 Feb 27.

CHU de Lille, Service de dermatologie, F-59000 Lille, France; Univ Lille, INSERM U995, Lille Inflammation Research International Center, F-59000, Lille, France. Electronic address:

Background: Dupilumab is the first biologic available to treat atopic dermatitis (AD). Its effectiveness and safety were demonstrated in clinical trials.

Objective: We sought to assess the effectiveness and safety of dupilumab in adults with AD in a real-life French multicenter retrospective cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193034
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http://dx.doi.org/10.1016/j.jaad.2019.02.053DOI Listing
July 2019
44 Reads
4.449 Impact Factor

Scn4b regulates the hypnotic effects of ethanol and other sedative drugs.

Genes Brain Behav 2019 07 2;18(6):e12562. Epub 2019 May 2.

Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas.

The voltage-gated sodium channel subunit β4 (SCN4B) regulates neuronal activity by modulating channel gating and has been implicated in ethanol consumption in rodent models and human alcoholics. However, the functional role for Scn4b in ethanol-mediated behaviors is unknown. We determined if genetic global knockout (KO) or targeted knockdown of Scn4b in the central nucleus of the amygdala (CeA) altered ethanol drinking or related behaviors. Read More

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http://dx.doi.org/10.1111/gbb.12562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612599PMC
July 2019
17 Reads

Correction to: Transcriptional Regulators as Targets for Alcohol Pharmacotherapies.

Handb Exp Pharmacol 2018 ;248:623-624

Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.

Figure 1 was published incorrectly in this chapter. The original chapter was corrected. Read More

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http://dx.doi.org/10.1007/164_2018_194DOI Listing
January 2018
5 Reads

Coordinated Emergence of Hippocampal Replay and Theta Sequences during Post-natal Development.

Curr Biol 2019 03 14;29(5):834-840.e4. Epub 2019 Feb 14.

Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address:

Hippocampal place cells encode an animal's current position in space during exploration [1]. During sleep, hippocampal network activity recapitulates patterns observed during recent experience: place cells with overlapping spatial fields show a greater tendency to co-fire ("reactivation") [2], and temporally ordered and compressed sequences of place cell firing observed during wakefulness are reinstated ("replay") [3-5]. Reactivation and replay may underlie memory consolidation [6-10]. Read More

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http://dx.doi.org/10.1016/j.cub.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408330PMC
March 2019
6 Reads

[Clinical outcomes after laser epithelial keratomileusis (LASEK) and transepithelial photorefractive keratectomy (TPRK) in myopia].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):122-126

Peking Union Medical College Hospital, Beijing 100730, China.

To compare the clinical outcomes between laser epithelial keratomileusis (LASEK) and transepithelial photorefractive keratectomy (TPRK) for treatment of myopia. Case-control study. We reviewed a total of 90 right eyes that underwent either LASEK or TPRK, with 45 eyes in each group (aged between 18 and 40 years; 9 males and 16 females in the LASEK group, and 30 males and 15 females in the TPRK group) from 2015 to 2016 in Peking Union Medical College Hospital and Tangshan Eye Hospital. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.010DOI Listing
February 2019
4 Reads

Risk factors for intraabdominal abscess formation after laparoscopic appendectomy - results from the Pol-LA (Polish Laparoscopic Appendectomy) multicenter large cohort study.

Wideochir Inne Tech Maloinwazyjne 2019 Jan 24;14(1):70-78. Epub 2018 Jul 24.

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Introduction: According to meta-analyses laparoscopic appendectomy is associated with many benefits. However, in comparison to open surgery an increased rate of intraabdominal abscesses (IAA) has been reported. Identification of predictive factors for this complication may help to identify patients with higher risk of IAA. Read More

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http://dx.doi.org/10.5114/wiitm.2018.77272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372867PMC
January 2019
8 Reads

Comparison of stump closure techniques during laparoscopic appendectomies for complicated appendicitis - results from Pol-LA (Polish laparoscopic appendectomy) multicenter large cohort study.

Acta Chir Belg 2020 Apr 12;120(2):116-123. Epub 2019 Feb 12.

2nd Department of General Surgery, Jagiellonian University Medical College, Kraków, Poland.

In general, the three main options for stump closure in laparoscopic appendectomy are clips, endoscopic staplers and endoloops. However, there is no gold standard, especially regarding complicated acute appendicitis which is generally associated with worse outcomes. We aimed to assess the outcomes of different stump closure techniques during laparoscopic appendectomies for complicated appendicitis Our multicenter observational study of 18 surgical units assessed the outcomes of 1269 laparoscopic appendectomies for complicated appendicitis that used the three main stump closure techniques: clips, staplers and endoloops. Read More

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http://dx.doi.org/10.1080/00015458.2019.1573527DOI Listing
April 2020
11 Reads

Comparison of the posterior corneal elevation and biomechanics after SMILE and LASEK for myopia: a short- and long-term observation.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 14;257(3):601-606. Epub 2019 Jan 14.

Department of Ophthalmology, Eye and ENT Hospital, Fudan University, No. 83 Fenyang Road, Shanghai, 200031, China.

Purpose: This study compares the posterior corneal elevation and corneal biomechanics after small incision lenticule extraction (SMILE) and laser-assisted subepithelial keratomileusis (LASEK) for myopia correction in a short- and long-term observation.

Methods: This prospective study included 32 patients in the SMILE group and 32 patients in the LASEK group. Corneal posterior central elevation (PCE), posterior mean elevation (PME), corneal back power (Kb), and anterior chamber depth (ACD) were evaluated with Pentacam, and intraocular pressure (IOP), corneal hysteresis (CH), and corneal resistance factor (CRF) were evaluated with the ORA at pre-operation and 3 months and 3 years post-operation. Read More

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http://link.springer.com/10.1007/s00417-018-04227-5
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http://dx.doi.org/10.1007/s00417-018-04227-5DOI Listing
March 2019
27 Reads

Is ITP really a desirable indication for teaching laparoscopic splenectomy? Cohort study.

Acta Chir Belg 2019 Dec 9;119(6):376-383. Epub 2019 Jan 9.

2nd Department of General Surgery, Jagiellonian University Medical College , Kraków , Poland.

: We aimed to evaluate the outcomes of laparoscopic splenectomy (LS) in patients with immune thrombocytopenic purpura (ITP) compared with operated for other indications. : Retrospective cohort study of patients who underwent LS in 1998-2017. Group 1 consisted of 256 patients operated for ITP, and Group 2 of 231 operated for other indications. Read More

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http://dx.doi.org/10.1080/00015458.2018.1545743DOI Listing
December 2019
10 Reads

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy.

Authors:

Br J Surg 2019 Jan;106(2):e103-e112

Background: The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy.

Methods: In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Read More

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http://doi.wiley.com/10.1002/bjs.11051
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http://dx.doi.org/10.1002/bjs.11051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492154PMC
January 2019
30 Reads
5.542 Impact Factor

Discharge of biocidal products from healthcare activities into a sewage system-a case study at a French university hospital.

Environ Sci Pollut Res Int 2019 Feb 19;26(5):4938-4951. Epub 2018 Dec 19.

Institute of Chemistry Materials and Natural Resources of Poitiers (IC2MP UMR 7285), University of Poitiers, 1 rue Marcel Doré, Bâtiment B1, TSA 41105, 86073, Poitiers Cedex 9, France.

This study focused on the presence of three biocidal products specific to healthcare facilities, i.e. chlorhexidine digluconate (CHD), bis(aminopropyl)laurylamine (BAPLA), and didecyldimethylammonium chloride (DDAC), in a hospital sewage system. Read More

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http://dx.doi.org/10.1007/s11356-018-3882-1DOI Listing
February 2019
6 Reads

The significant impact of age on the clinical outcomes of laparoscopic appendectomy: Results from the Polish Laparoscopic Appendectomy multicenter large cohort study.

Medicine (Baltimore) 2018 Dec;97(50):e13621

Faculty of Health Sciences, Powiślańska School in Kwidzyn, Kwidzyn.

Acute appendicitis (AA) is the most common surgical emergency and can occur at any age. Nearly all of the studies comparing outcomes of appendectomy between younger and older patients set cut-off point at 65 years. In this multicenter observational study, we aimed to compare laparoscopic appendectomy for AA in various groups of patients with particular interest in the elderly and very elderly in comparison to younger adults. Read More

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http://dx.doi.org/10.1097/MD.0000000000013621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320074PMC
December 2018
20 Reads

Quest for the optimal technique of laparoscopic splenectomy - vessels first or hilar transection?

Wideochir Inne Tech Maloinwazyjne 2018 Dec 30;13(4):460-468. Epub 2018 May 30.

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Introduction: Throughout our 20 years of experience, we have used several different techniques for laparoscopic splenectomy (LS). However, two methods have been used most frequently: "vessels first" and "hilar transection".

Aim: To evaluate the outcomes of LS performed with these two different approaches. Read More

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https://www.termedia.pl/doi/10.5114/wiitm.2018.76071
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http://dx.doi.org/10.5114/wiitm.2018.76071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280088PMC
December 2018
35 Reads

Corneal Surface Ablation Laser Refractive Surgery for the Correction of Myopia: A Network Meta-analysis.

J Refract Surg 2018 Nov;34(11):726-735

Purpose: To systematically compare the efficacy, predictability, safety, postoperative haze, pain scores, and epithelial healing time of four corneal surface ablation procedures.

Methods: PubMed, Embase, Cochrane Library, and the U.S. Read More

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https://www.healio.com/doiresolver?doi=10.3928/1081597X-2018
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http://dx.doi.org/10.3928/1081597X-20180905-01DOI Listing
November 2018
39 Reads