1,007 results match your criteria LASEK

Children with psoriasis and COVID-19: factors associated with an unfavourable COVID-19 course, and the impact of infection on disease progression (Chi-PsoCov registry).

J Eur Acad Dermatol Venereol 2022 Jun 24. Epub 2022 Jun 24.

Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden; Dermatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Background: The COVID-19 pandemic has raised questions regarding the management of chronic skin diseases, especially in patients on systemic treatments. Data concerning the use of biologics in adults with psoriasis are reassuring, but data specific to children are missing. Moreover, COVID-19 could impact the course of psoriasis in children. Read More

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The Development of a Comprehensive Mental Health Service for Medical Trainees.

Acad Med 2022 Jun 21. Epub 2022 Jun 21.

S. Hasan is an assistant professor, Department of Psychiatry, and director, Mental Health Services, Indiana University School of Medicine, Indianapolis, Indiana; ORCID: https://orcid.org/0000-0002-6546-5007.

Mental distress in medical learners and its consequent harmful effects on personal and professional functioning, a well-documented concern, draws attention to the need for solutions. The authors review the development of a comprehensive mental health service within a large and complex academic medical education system, created with special attention to offering equitable, accessible, and responsive care to all trainees. From the inception of the service in January 2017, the authors placed particular emphasis on eliminating obstacles to learners' willingness and ability to access care, including concerns related to cost, session limits, privacy, and flexibility with modality of service delivery. Read More

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Femtosecond laser assisted superficial lamellar keratectomy as a successful treatment of corneal opacity in a patient with Thiel Behnke corneal dystrophy.

Int J Surg Case Rep 2022 Jun 31;95:107257. Epub 2022 May 31.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia; Department of Pathology & Laboratory Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Introduction And Importance: Thiel Behnke corneal dystrophy (TBCD) and Reis Buckler corneal dystrophy (RBCD) are Bowman's layer dystrophies with overlapping clinical features causing diagnostic confusion. However, each entity has typical histopathological features. We describe in this case the successful use of Femtosecond laser (FSL) in the treatment of TBCD-related corneal opacity. Read More

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Controlling Stoichiometry in Ultrathin van der Waals Films: PtTe, PtTe, PtTe, and PtTe.

ACS Nano 2022 Jun 2. Epub 2022 Jun 2.

Department of Physics, University of South Florida, Tampa, Florida 33620, United States.

The platinum-tellurium phase diagram exhibits various (meta)stable van der Waals (vdW) materials that can be constructed by stacking PtTe and PtTe layers. Monophase PtTe, being the thermodynamically most stable compound, can readily be grown as thin films. Obtaining the other phases (PtTe, PtTe, PtTe), especially in their ultimate thin form, is significantly more challenging. Read More

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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study.


Lancet Glob Health 2022 Jul 24;10(7):e1003-e1011. Epub 2022 May 24.

Background: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.

Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. Read More

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Effect of a brain-penetrant selective estrogen receptor degrader (SERD) on binge drinking in female mice.

Alcohol Clin Exp Res 2022 May 17. Epub 2022 May 17.

Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.

Background: Greater circulating levels of the steroid hormone 17β-estradiol (E2) are associated with higher levels of binge drinking in women. In female mice, estrogen receptors in the ventral tegmental area, a dopaminergic region of the brain involved in the motivation to consume ethanol, regulate binge-like ethanol intake. We recently developed a brain-penetrant selective estrogen receptor degrader (SERD), YL3-122, that could be used to test the behavioral role of brain estrogen receptors. Read More

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Laser-based refractive surgery techniques to treat myopia in adults. An overview of systematic reviews and meta-analyses.

Acta Ophthalmol 2022 May 9. Epub 2022 May 9.

Hospital Lluís Alcanyís, Xàtiva, Spain.

Systematic reviews (SRs) and meta-analyses (MAs) are of great importance for basing clinical decisions. However, misleading interpretations may result when informed decisions rest on biased review papers with methodological issues. To evaluate which treatment is optimal, an overview was made of SRs and MAs to establish the quality and certainty of meta-evidence published on the efficacy of laser-based refractive surgery techniques for treating myopia in adults. Read More

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Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure.

Sci Adv 2022 05 4;8(18):eabn2748. Epub 2022 May 4.

Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA.

Adolescent binge drinking is a major risk factor for psychiatric disorders later in life including alcohol use disorder. Adolescent alcohol exposure induces epigenetic reprogramming at the enhancer region of the activity-regulated cytoskeleton-associated protein (Arc) immediate-early gene, known as synaptic activity response element (SARE), and decreases expression in the amygdala of both rodents and humans. The causal role of amygdalar epigenomic regulation at SARE in adult anxiety and drinking after adolescent alcohol exposure is unknown. Read More

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Effectiveness and Safety of Adalimumab, Etanercept and Ustekinumab for Severe Psoriasis in Children Under 12 Years of Age: A French-Italian Daily Practice Cohort (BiPe Jr).

Paediatr Drugs 2022 May 10;24(3):281-292. Epub 2022 Apr 10.

Dermatology Department, Hôpital Victor Dupouy, Argenteuil, France.

Introduction: Biological therapies are valuable treatments for severe psoriasis. Children aged under 12 years are underrepresented in therapeutic trials for these drugs. The objective of the 'BiPe Jr' cohort study was to evaluate the drug survival, effectiveness, tolerance and switching patterns of biological therapies in children under 12 years of age with psoriasis. Read More

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Long-Term Visual and Refractive Stability and Ocular Biometric Changes after Laser-Assisted Subepithelial Keratomileusis for Correction of Myopia: An 8-Year Follow-Up.

J Curr Ophthalmol 2021 Oct-Dec;33(4):417-421. Epub 2022 Jan 6.

Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To assess the long-term visual and refractive stability and ocular biometric changes in low to moderate myopic subjects treated by laser-assisted subepithelial keratomileusis (LASEK).

Methods: It is a prospective, interventional study. Included were 70 eyes of 35 patients who underwent LASEK for correction of ≤6 diopters (D) myopia. Read More

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January 2022

5'-Phosphonate modified oligoadenylates as potent activators of human RNase L.

Bioorg Med Chem 2022 02 19;56:116632. Epub 2022 Jan 19.

IOCB Prague, Flemingovo nam. 2, 160 00 Prague, Czech Republic. Electronic address:

The oligoadenylate synthetase-ribonuclease L pathway is a major player in the interferon-induced antiviral defense mechanism of cells. Upon sensing viral dsRNA, 5'-phosphorylated 2',5'-oligoadenylates are synthesized, and subsequently activate latent RNase L. To determine the influence of 5'-phosphate end on the activation of human RNase L, four sets of 5'-phosphonate modified oligoadenylates were prepared on solid-phase. Read More

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February 2022

Switching biologics in children with psoriasis: Results from the BiPe cohort.

Pediatr Dermatol 2022 Jan 9;39(1):35-41. Epub 2021 Dec 9.

Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France.

Background: There is currently little information on switching biologics in pediatric psoriasis.

Objective: To evaluate the real-world clinical practice and safety of switching biologics in the "Biological Treatments for Pediatric Psoriasis" (BiPe) cohort.

Methods: Data for all 134 patients included in the BiPe cohort were analyzed. Read More

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January 2022

Characteristics of diluted-stored and post-thawed semen of Hutsul stallions.

Acta Vet Hung 2021 Nov 25. Epub 2021 Nov 25.

1 Department of Animal Reproduction, Anatomy and Genomics, University of Agriculture in Krakow, Mickiewicza 24/28, 30-059, Krakow, Poland.

The use of frozen semen lowers the risk of disease transmission, eliminates geographical limitations and supports the implementation of genetic resource protection programs. However, due to the very rare use of frozen semen from Hutsul stallions, their genetic material is not secured in sperm banks, and very little information is available about their semen, including its suitability for cryopreservation, and sperm survival rates after thawing. The aim of this study was to analyse basic parameters such as sperm motility, vitality and morphology in diluted-stored and post-thawed Hutsul semen, using a CASA system. Read More

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November 2021

Therapeutic metastatic prostate cancer vaccines: lessons learnt from urologic oncology.

Cent European J Urol 2021 11;74(3):300-307. Epub 2021 Jun 11.

Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Warsaw, Poland.

Introduction: Therapeutic cancer vaccines have been recognized as a promising treatment option in clinical oncology for nearly three decades. However, despite many efforts, only one cancer vaccine - sipuleucel-T, activating the anti-PAP (prostatic acid phosphatase) immune response, has obtained Food and Drug Administration (FDA) approval.

Material And Methods: This review describes the most advanced research on the use of therapeutic cancer vaccines in the treatment of prostate cancer. Read More

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Neuroglia - development and role in physiological and pathophysiological processes.

Folia Morphol (Warsz) 2021 26;80(4):766-775. Epub 2021 Oct 26.

Department of Normal Anatomy, Pomeranian Medical University, Szczecin, Poland.

The dynamic development of studies on neuroglia in recent years indicates its previously underestimated role in maintaining proper brain function, both in physiological and pathological conditions. The use of modern research methods such as single-cell techniques as well as in vivo and in vitro models enriched the state of our knowledge. The most important issues regarding the maturation and development of neuroglia include cooperation between glial cell groups and with neurons in neurogenesis, neuroregeneration, (re)myelination and how the early developmental roles of glia contribute to nervous system dysfunction in neurodevelopmental and neurodegenerative disorders. Read More

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December 2021

Intra-Operative Discomfort in Photorefractive Keratectomy.

Clin Ophthalmol 2021 13;15:4121-4130. Epub 2021 Oct 13.

Department of Ophthalmology, Saint Alphonsus Health System, Boise, ID, USA.

Purpose: Photorefractive keratectomy (PRK) remains a viable, safe, and efficacious option for patients wishing to correct refractive errors. One of its most significant drawbacks is pain. While post-operative pain has been well studied with different management options, intra-operative pain has been less well defined. Read More

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October 2021

Plasmidome of spp.-The -Family Business.

Int J Mol Sci 2021 Sep 25;22(19). Epub 2021 Sep 25.

Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.

Bacteria of the genus (phylum ) include both human and animal pathogens, as well as saprophytic strains. A common component of spp. genomes are plasmids, i. Read More

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September 2021

Comparison of Corneal Biomechanics in Post-SMILE, Post-LASEK, and Keratoconic Eyes.

Front Med (Lausanne) 2021 14;8:695697. Epub 2021 Sep 14.

Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.

Our study found that SP-A1 (stiffness parameter at time of first applanation) was statistically different between post-laser-assisted subepithelial keratomileusis (LASEK) and post-small incision lenticule extraction (SMILE) eyes. The stiffness of keratoconus was lower than that of post-refractive surgery corneas. To compare corneal biomechanics among post-SMILE, post-LASEK, and keratoconic eyes. Read More

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September 2021

Feelings of guilt in parents of children with atopic dermatitis.

J Eur Acad Dermatol Venereol 2022 Feb 8;36(2):e155-e157. Epub 2021 Oct 8.

Service de Dermatologie, Centre Hospitalier Universitaire de Brest, Brest, France.

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February 2022

Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel.

Sci Transl Med 2021 Sep 8;13(610):eabd4811. Epub 2021 Sep 8.

Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA.

Paclitaxel (Taxol) is a cornerstone of cancer treatment. However, its mechanism of cytotoxicity is incompletely understood and not all patients benefit from treatment. We show that patients with breast cancer did not accumulate sufficient intratumoral paclitaxel to induce mitotic arrest in tumor cells. Read More

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September 2021

Effects of warm compress on tear film, blink pattern and Meibomian gland function in dry eyes after corneal refractive surgery.

BMC Ophthalmol 2021 Sep 10;21(1):330. Epub 2021 Sep 10.

Department of Ophthalmology and Optometry, Eye and ENT Hospital of Fudan University, Shanghai, China.

Background: To assess the effects of warm compress (WC) on tear film lipid layer, blink pattern and Meibomian gland function in patients with dry eye following femtosecond laser small incision lenticule extraction (SMILE) and laser-assisted subepithelial keratomileusis (LASEK).

Methods: We enrolled 37 eyes of 37 participants, each with dry eye for more than 2 years following SMILE (25 eyes) or LASEK (12 eyes). WC was performed using a spontaneously heating eye mask. Read More

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September 2021

Peripheral Hypertrophic Subepithelial Corneal Degeneration on a Laser-Assisted In Situ Keratomileusis Flap.

Eye Contact Lens 2022 Jan;48(1):51-53

Princess Alexandra Hospital (Y.L.), Brisbane, Australia; Ashford Advanced Eye Care (B.R.L.), Adelaide, Australia; The Queen Elizabeth Hospital (B.R.L.), Adelaide, Australia; South Australian Institute of Ophthalmology (B.R.L.), Adelaide, Australia; and University of Adelaide (B.R.L.), Adelaide, Australia.

Abstract: We describe the first reported case of a patient developing peripheral hypertrophic subepithelial corneal degeneration (PHSCD) in the setting of previous femtosecond laser in situ keratomileusis (LASIK). Superficial keratectomy was performed successfully with the complete restoration of the visual acuity, no LASIK flap complications, and no recurrence of PHSCD at 1-year follow-up. Our case indicates that superficial keratectomy can be a safe and effective treatment for PHSCD in the setting of LASIK and raises awareness of the possibility of PHSCD developing in eyes that have undergone prior LASIK. Read More

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January 2022

Characteristics of children and adolescents with atopic dermatitis who attended therapeutic patient education.

J Eur Acad Dermatol Venereol 2021 Nov 29;35(11):2263-2269. Epub 2021 Jul 29.

Department of Dermatology, Hôpital Necker, AP-HP, Paris, France.

Background: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease. Therapeutic patient education (TPE) has been demonstrated to be effective in AD in reducing disease severity and improving coping and quality of life.

Objectives: To describe the sociodemographic and clinical characteristics of children and adolescents with AD who had attended TPE sessions, as well as the characteristics of their parents, and compare them with those who did not attend TPE. Read More

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November 2021

Severe Corneal Morphological Alterations after Excimer Laser Surface Ablation for a High Astigmatism.

Case Rep Ophthalmol 2021 May-Aug;12(2):492-496. Epub 2021 Jun 11.

Ophthalmology Unit, Department of Biomedical Sciences, University Hospital of Messina, Messina, Italy.

We report long-term alterations of anterior corneal stroma after excimer laser surface ablation for a high astigmatism. The patient claimed progressive visual loss in his right eye (RE) during the last 3 years after bilateral laser-assisted subepithelial keratectomy (LASEK) surgery. His examination comprised visual acuity (UDVA and CDVA), slit-lamp examination, corneal topography and tomography, AS-OCT, and confocal microscopy. Read More

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Letter to the Editor: Laser Enhancements After Surface Ablation.

Ophthalmol Ther 2021 Sep 9;10(3):699-700. Epub 2021 Jul 9.

Príncipe de Asturias University Hospital, Alcala de Henares, Madrid, Spain.

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September 2021

Risk Factors for the Structural Progression of Myopic Glaucomatous Eyes with a History of Laser Refractive Surgery.

J Clin Med 2021 May 29;10(11). Epub 2021 May 29.

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul 03722, Korea.

As laser refractive surgeries (LRS) have been widely performed to correct myopia, ophthalmologists easily encounter patients with glaucoma who have a history of LRS. It is well known that intraocular pressure (IOP) in eyes with glaucoma is not accurate when measured using Goldmann applanation tonometry. However, risk factors for glaucoma progression, particularly those associated with measured IOP, have rarely been studied. Read More

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Ensiling of maple leaves and its use in winter nutrition of mantled guereza (Colobus guereza).

Zoo Biol 2021 Sep 25;40(5):436-443. Epub 2021 May 25.

Department of Animal Nutrition and Biotechnology, and Fisheries, University of Agriculture in Krakow, Al. A. Mickiewicza 24/28, Krakow, Poland.

Young leaves are favored by mantled guereza (Colobus guereza) and the gastrointestinal tract of this species is well adapted to such a high fiber diet. Fresh maple leaves are often used in the diets for guereza in captivity but their use in winter feeding time is limited. The aim of the study was to evaluate the effect of additives on chemical composition and fermentation parameters of maple leaf silage, as well as inclusion of maple leaf silage in the diet for mantled guereza on feed and nutrient intake. Read More

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September 2021

Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure.

Transl Psychiatry 2021 05 20;11(1):298. Epub 2021 May 20.

Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, 60612, USA.

Alcohol use disorder (AUD) is highly comorbid with depression. Withdrawal from chronic alcohol drinking results in depression and understanding brain molecular mechanisms that drive withdrawal-related depression is important for finding new drug targets to treat these comorbid conditions. Here, we performed RNA sequencing of the rat hippocampus during withdrawal from chronic alcohol drinking to discover key signaling pathways involved in alcohol withdrawal-related depressive-like behavior. Read More

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