976 results match your criteria LASEK

Postoperative corneal biomechanics and influencing factors during femtosecond-assisted laser in situ keratomileusis (FS-LASIK) and laser-assisted subepithelial keratomileusis (LASEK) for high myopia.

Lasers Med Sci 2021 Apr 23. Epub 2021 Apr 23.

Eye Hospital of Shandong First Medical University, 372 Jingsi Road, Jinan, 250021, China.

The purpose of this study is to compare the postoperative corneal biomechanics and assess the influence factors after femtosecond-assisted laser in situ keratomileusis (FS-LASIK) and laser-assisted subepithelial keratomileusis (LASEK) for high myopia. In this retrospective study, patients who completed 1-year follow-up were included. The corneal biomechanical parameters, including deformation amplitude ratio 2. Read More

View Article and Full-Text PDF

Synthesis of phosphonate derivatives of 2'-deoxy-2'-fluorotetradialdose d-nucleosides and tetradialdose d-nucleosides.

Tetrahedron 2021 Apr 16:132159. Epub 2021 Apr 16.

IOCB Prague, Flemingovo Nam. 2, 160 00, Prague, Czech Republic.

Analogs of nucleosides and nucleotides represent a promising pool of potential therapeutics. This work describes a new synthetic route leading to 2'-deoxy-2'-fluorotetradialdose D-nucleoside phosphonates. Moreover, a new universal synthetic route leading to tetradialdose d-nucleosides bearing purine nucleobases is also described. Read More

View Article and Full-Text PDF

Effect of Laser-assisted Subepithelial Keratectomy with Mitomycin C on Corneal Optical Density Measured with Confocal Microscopy.

Optom Vis Sci 2021 Apr;98(4):350-354

Clínica Novovisión, Madrid, Spain.

Significance: The development of confocal microscopy allows one to obtain high-resolution corneal images like its optical density. Some studies have evaluated the optical density with Scheimpflug cameras in the early post-operative period after photorefractive keratectomy, but no studies have evaluated the long-term evolution of optical density after surface ablation when mitomycin C is used.

Purpose: This work aimed to study the changes in corneal optical density measured with confocal microscopy in eyes treated with laser-assisted subepithelial keratectomy (LASEK) and intraoperative mitomycin C (MMC) to correct myopia. Read More

View Article and Full-Text PDF

[Corneal nerve repair and optical density in patients with high myopia after three kinds of corneal refractive surgery].

Zhonghua Yan Ke Za Zhi 2021 Apr;57(4):268-276

Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.

To investigate the repair of subepithelial nerve fibers in different areas of the cornea and the difference of corneal transparency 12 months after small incision lenticule extraction (SMILE), femtosecond laser in situ keratomileusis (FS-LASIK) and excimer laser in situ keratomileusis (LASEK) in high myopia. A cohort study. From June 2018 to October 2019, 30 patients with high myopia (60 eyes) were selected for corneal refractive surgery in the Department of Ophthalmology, Affiliated Hospital of Qingdao University, including 16 females (32 eyes) and 14 males (28 eyes). Read More

View Article and Full-Text PDF

Interactions of Linear Analogues of Battacin with Negatively Charged Lipid Membranes.

Membranes (Basel) 2021 Mar 10;11(3). Epub 2021 Mar 10.

Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland.

The increasing resistance of bacteria to available antibiotics has stimulated the search for new antimicrobial compounds with less specific mechanisms of action. These include the ability to disrupt the structure of the cell membrane, which in turn leads to its damage. In this context, amphiphilic lipopeptides belong to the class of the compounds which may fulfill this requirement. Read More

View Article and Full-Text PDF

Predicting the safety zone for steroid-induced ocular hypertension induced by intravitreal dexamethasone implantation.

Br J Ophthalmol 2021 Mar 18. Epub 2021 Mar 18.

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.

Background/aims: This study aimed to predict the possibility of steroid-induced ocular hypertension (OHT) after intravitreal dexamethasone (DEX) implantation and to identify a proper safety zone for such injections.

Methods: A cross-sectional observational study was conducted and included 908 patient eyes that underwent DEX implant injection due to various retinal diseases. Intraocular pressure (IOP) was measured before injection, at 1 week, and at 1, 2, 3, 6 and 12 months thereafter. Read More

View Article and Full-Text PDF

The Effectiveness of Corneal Epithelial Debridement Performed with an Alcohol-Impregnated Sponge.

Klin Monbl Augenheilkd 2021 Mar 17. Epub 2021 Mar 17.

Niv Eye Center, Adana, Turkey.

Objective: To evaluate the clinical outcomes of patients who underwent corneal surgery with debridement of epithelium by localised application of an alcohol-impregnated sponge instead of the usual alcohol reservoir method.

Design: This study retrospectively included 52 eyes of 27 patients who underwent LASEK (laser-assisted subepithelial keratectomy) and CXL (cross-linking) surgery after application of this alcohol-assisted debridement method between January 2019 and April 2019.

Participants: Twenty-four patients who underwent LASEK and three patients who underwent CXL surgery were included in this study, which comprised a total of 52 eye operations. Read More

View Article and Full-Text PDF

Binge-like ethanol drinking activates anaplastic lymphoma kinase signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortex.

Genes Brain Behav 2021 Feb 28:e12729. Epub 2021 Feb 28.

Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.

Alcohol use disorder (AUD) has a complex pathogenesis, making it a difficult disorder to treat. Identifying relevant signaling pathways in the brain may be useful for finding new pharmacological targets to treat AUD. The receptor tyrosine kinase anaplastic lymphoma kinase (ALK) activates the transcription factor STAT3 in response to ethanol in cell lines. Read More

View Article and Full-Text PDF
February 2021

Acute acral eruptions in children during the COVID-19 pandemic: Characteristics of 103 children and their family clusters.

Ann Dermatol Venereol 2021 Jan 9. Epub 2021 Jan 9.

Universities of Tours and Nantes, inserm 1246-SPHERE, 37000 Tours, France; Tours University Hospital, Department of Dermatology, 37044 Tours Cedex 9, France; Tours University Hospital, Clinical Investigation Center-INSERM 1415, 37000 Tours, France. Electronic address:

Background: A marked increase in frequency of acute acral eruptions (AAE) was observed in children during the COVID-19 pandemic in the spring period.

Objectives: In this observational multicenter study, based on children with AAE, we aimed to assess the proportion of household members possibly infected by SARS-CoV-2.

Methods: We collected data from all children observed with AAE, prospectively from April 7, 2020 to June 22, 2020, and retrospectively since February 28, 2020. Read More

View Article and Full-Text PDF
January 2021

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries.


Lancet 2021 Jan 21;397(10272):387-397. Epub 2021 Jan 21.

Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality.

Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. Read More

View Article and Full-Text PDF
January 2021

Epigenetic mechanisms underlying stress-induced depression.

Int Rev Neurobiol 2021 26;156:87-126. Epub 2020 Sep 26.

Department of Psychiatry, Center for Alcohol Research in Epigenetics, University of Illinois at Chicago, Chicago, IL, United States. Electronic address:

Stressful life events are a major contributor to the development of major depressive disorder. Environmental perturbations like stress change gene expression in the brain, leading to altered behavior. Gene expression is ultimately regulated by chromatin structure and the epigenetic modifications of DNA and the histone proteins that make up chromatin. Read More

View Article and Full-Text PDF
September 2020

Motor signs in Alzheimer's disease and vascular dementia: Detection through natural language processing, co-morbid features and relationship to adverse outcomes.

Exp Gerontol 2021 Apr 12;146:111223. Epub 2021 Jan 12.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; South London and Maudsley NHS Foundation Trust, London, UK. Electronic address:

Background: Motor signs in patients with dementia are associated with a higher risk of cognitive decline, institutionalisation, death and increased health care costs, but prevalences differ between studies. The aims of this study were to employ a natural language processing pipeline to detect motor signs in a patient cohort in routine care; to explore which other difficulties occur co-morbid to motor signs; and whether these, as a group and individually, predict adverse outcomes.

Methods: A cohort of 11,106 patients with dementia in Alzheimer's disease, vascular dementia or a combination was assembled from a large dementia care health records database in Southeast London. Read More

View Article and Full-Text PDF

Wavefront excimer laser refractive surgery for adults with refractive errors.

Cochrane Database Syst Rev 2020 12 18;12:CD012687. Epub 2020 Dec 18.

Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA.

Background: Refractive errors (conditions in which the eye fails to focus objects accurately on the retina due to defects in the refractive system), are the most common cause of visual impairment. Myopia, hyperopia, and astigmatism are low-order aberrations, usually corrected with spectacles, contact lenses, or conventional refractive surgery. Higher-order aberrations (HOAs) can be quantified with wavefront aberration instruments and corrected using wavefront-guided or wavefront-optimized laser surgery. Read More

View Article and Full-Text PDF
December 2020

Effects of taking pregabalin (Lyrica) on the severity of dry eye, corneal sensitivity and pain after laser epithelial keratomileusis surgery.

Br J Ophthalmol 2020 Dec 10. Epub 2020 Dec 10.

Department of Ophthalmology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea (the Republic of)

Background: Corneal nerve damage after laser epithelial keratomileusis (LASEK) is thought to be the cause of dry eye and pain. Therefore, we investigated whether taking pregabalin (Lyrica), which reduces peripheral neuropathic pain, alleviates corneal nerve sensitivity after surgery and reduces dry eye and pain.

Methods: Patients were treated with pregabalin (150 mg two times a day for 15 days) from the day before surgery onward and compared with those who did not receive the medications. Read More

View Article and Full-Text PDF
December 2020

Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs).

Sci Rep 2020 12 9;10(1):21542. Epub 2020 Dec 9.

Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.

The introduction of femtosecond laser-assisted cataract surgery is an alternative approach to conventional cataract surgery. Our study aimed to determine the effectiveness of femtosecond laser-assisted capsulotomy in the presence of different ophthalmic viscoelastic devices (OVDs) in the anterior chamber. Fresh porcine eyes (n = 96) underwent LDV Z8-assisted anterior capsulotomy, either in the presence of an OVD (Viscoat, Provisc, Healon, Healon GV or HPMC) or without, using 90% and 150% energies respectively. Read More

View Article and Full-Text PDF
December 2020

Residual, differential neurobehavioral deficits linger after multiple recovery nights following chronic sleep restriction or acute total sleep deprivation.

Sleep 2021 04;44(4)

Biological Rhythms Research Laboratory, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL.

Study Objectives: The amount of recovery sleep needed to fully restore well-established neurobehavioral deficits from sleep loss remains unknown, as does whether the recovery pattern differs across measures after total sleep deprivation (TSD) and chronic sleep restriction (SR).

Methods: In total, 83 adults received two baseline nights (10-12-hour time in bed [TIB]) followed by five 4-hour TIB SR nights or 36-hour TSD and four recovery nights (R1-R4; 12-hour TIB). Neurobehavioral tests were completed every 2 hours during wakefulness and a Maintenance of Wakefulness Test measured physiological sleepiness. Read More

View Article and Full-Text PDF

Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study.


BMJ Glob Health 2020 12;5(12)

Introduction: Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings. Read More

View Article and Full-Text PDF
December 2020

Comparison of the Levels of Transforming Growth Factor-β1 in Tear Fluid in Patients with High Myopia after Transepithelial Photorefractive Keratectomy and Laser Subepithelial Keratomileusis (LASEK).

Bull Exp Biol Med 2020 Nov 24;170(1):79-83. Epub 2020 Nov 24.

Huashan Eye Hospital of Kunming, Kunming, Yunnan Province, PR China.

We compared the level of transforming growth factor-β1 (TGF-β1) in the tear fluid of 20 patients with high myopia who underwent transepithelial photorefractive keratectomy (T-PRK) in one eye and laser subepithelial keratomileusis (LASEK) in the contralateral eye. Tear fluid samples were collected with scaled microcapillary tubes before (day 0) and on days 1, 3, and 5 after surgery. The release of TGF-β1 was determined by multiplying the concentration of TGF-β1 by capillary tear fluid flow. Read More

View Article and Full-Text PDF
November 2020

Physicochemical and Biological Characterization of Novel Membrane-Active Cationic Lipopeptides with Antimicrobial Properties.

Langmuir 2020 11 21;36(43):12900-12910. Epub 2020 Oct 21.

Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury101, 02-089 Warsaw, Poland.

We have designed and synthesized new short lipopeptides composed of tetrapeptide conjugated to fatty acids with different chain lengths. The amino acid sequence of the peptide moiety included d-phenylalanine, two residues of l-2,4-diaminobutyric acid and l-leucine. To explore the possible mechanism of lipopeptide action, we have provided a physicochemical characterization of their interactions with artificial lipid membranes. Read More

View Article and Full-Text PDF
November 2020

Industrial tests of co-combustion of alternative fuel with hard coal in a stoker boiler.

J Air Waste Manag Assoc 2021 Mar 4;71(3):339-347. Epub 2021 Jan 4.

Institute for Chemical Processing of Coal, Zabrze, Poland.

This paper presents the results of industrial research on co-combustion of solid recovered fuel (SRF) with hard coal in a stoker boiler type WR-25. The share of SRF in the fuel mixture was 10%. During the co-combustion of SRF, no technological disturbances of the boiler were noted. Read More

View Article and Full-Text PDF

Targeting Type II Toxin-Antitoxin Systems as Antibacterial Strategies.

Toxins (Basel) 2020 09 4;12(9). Epub 2020 Sep 4.

Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.

The identification of novel targets for antimicrobial agents is crucial for combating infectious diseases caused by evolving bacterial pathogens. Components of bacterial toxin-antitoxin (TA) systems have been recognized as promising therapeutic targets. These widespread genetic modules are usually composed of two genes that encode a toxic protein targeting an essential cellular process and an antitoxin that counteracts the activity of the toxin. Read More

View Article and Full-Text PDF
September 2020

The Prevalence of Infectious Keratitis after Keratorefractive Surgery: A Systematic Review and Meta-Analysis Study.

J Ophthalmol 2020 28;2020:6329321. Epub 2020 Jul 28.

Halal Research Center of IRI, FDA, Tehran, Iran.

Background: The keratorefractive surgeries (KRS) are one of the most common ocular surgeries. One of the dangerous complications of these surgeries is infectious keratitis (IK), which is the second cause of blindness after cataract surgery. The purpose of this study was to estimate the prevalence of IK after KRS in different parts of the world. Read More

View Article and Full-Text PDF

Quantum advantage in postselected metrology.

Nat Commun 2020 Jul 29;11(1):3775. Epub 2020 Jul 29.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

In every parameter-estimation experiment, the final measurement or the postprocessing incurs a cost. Postselection can improve the rate of Fisher information (the average information learned about an unknown parameter from a trial) to cost. We show that this improvement stems from the negativity of a particular quasiprobability distribution, a quantum extension of a probability distribution. Read More

View Article and Full-Text PDF

In vivo creation of plasmid pCRT01 and its use for the construction of carotenoid-producing Paracoccus spp. strains that grow efficiently on industrial wastes.

Microb Cell Fact 2020 Jul 13;19(1):141. Epub 2020 Jul 13.

Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096, Warsaw, Poland.

Background: Carotenoids are natural tetraterpene pigments widely utilized in the food, pharmaceutical and cosmetic industries. Currently, chemical synthesis of these compounds outperforms their production in Escherichia coli or yeast due to the limited efficiency of the latter. The use of natural microbial carotenoid producers, such as bacteria of the genus Paracoccus (Alphaproteobacteria), may help to optimize this process. Read More

View Article and Full-Text PDF

Molecular Beam Epitaxy of Transition Metal (Ti-, V-, and Cr-) Tellurides: From Monolayer Ditellurides to Multilayer Self-Intercalation Compounds.

ACS Nano 2020 Jul 29;14(7):8473-8484. Epub 2020 Jun 29.

Department of Physics, University of South Florida, Tampa, Florida 33620, United States.

Material growth by van der Waals epitaxy has the potential to isolate monolayer (ML) materials and synthesize ultrathin films not easily prepared by exfoliation or other growth methods. Here, the synthesis of the early transition metal (Ti, V, and Cr) tellurides by molecular beam epitaxy (MBE) in the mono- to few-layer regime is investigated. The layered ditellurides of these materials are known for their intriguing quantum- and layer dependent- properties. Read More

View Article and Full-Text PDF

Visual outcomes after three different surgical procedures for correction of refractive error in patients with thin corneas.

Int J Ophthalmol 2020 18;13(6):970-977. Epub 2020 Jun 18.

Seoul Daabom Eye Center, Cheoungju, Chungbuk 28644, Republic of Korea.

Aim: To investigate and compare the visual and refractive outcomes of small incision lenticule extraction (SMILE), laser assisted sub-epithelial keratomileusis (LASEK), and LASEK combined with corneal collagen cross-linking (LASEK-CXL) surgery in patients with less than 500 µm of central corneal thickness (CCT).

Methods: The retrospective medical records review was conducted on the patients with CCT less than 500 µm treated with SMILE, LASEK, and LASEK-CXL. There was a total of 172 eyes, 76 eyes were in the SMILE group, 53 eyes in the LASEK group, and 43 eyes in the LASEK-CXL group. Read More

View Article and Full-Text PDF

Comparative Study of Immunomodulatory Agents to Induce Human T Regulatory (Treg) Cells: Preferential Treg-Stimulatory Effect of Prednisolone and Rapamycin.

Arch Immunol Ther Exp (Warsz) 2020 Jun 12;68(4):20. Epub 2020 Jun 12.

Department of Immunology, Centre of Biostructure Research, Medical University of Warsaw, Warsaw, Poland.

T regulatory (Treg) cells play a critical role in the maintenance of self-tolerance, as well as in inhibition of inflammation and exaggerated immune response against exogenous antigens. They develop in the thymus (tTreg cells) but also may be generated at the peripheral tissues, including tumor microenvironment (pTreg cells), or induced in vitro in the presence of transforming growth factor (TGF)-β (iTreg cells). Since tTreg cells constitute a minor fraction of peripheral blood lymphocytes in physiological conditions, an alternative way to obtain high number of functional Treg cells for therapeutic purposes is their generation in vitro from conventional T cells. Read More

View Article and Full-Text PDF

Estrogen Receptor α Regulates Ethanol Excitation of Ventral Tegmental Area Neurons and Binge Drinking in Female Mice.

J Neurosci 2020 07 1;40(27):5196-5207. Epub 2020 Jun 1.

Center for Alcohol Research in Epigenetics and Department of Psychiatry

Elevations in estrogen (17β-estradiol, E2) are associated with increased alcohol drinking by women and experimentally in rodents. E2 alters the activity of the dopamine system, including the VTA and its projection targets, which plays an important role in binge drinking. A previous study demonstrated that, during high E2 states, VTA neurons in female mice are more sensitive to ethanol excitation. Read More

View Article and Full-Text PDF