56 results match your criteria Kyrle Disease


Kyrle's disease associated with HIV infection, diabetes, and chronic kidney disease.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):414-417

Postgraduate Program in Public Health; School of Medicine, Health Sciences Center, University of Fortaleza, Fortaleza, Ceara, Brazil.

Kyrle's disease (KD) is a rare skin pathology characterized by transepidermal elimination of abnormal keratin. The aim of this article is to report a rare case of KD associated with diabetes mellitus, chronic kidney disease, and HIV. A 51-year-old male patient complained of diarrhea for 8 months. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_532_17DOI Listing
November 2018
6 Reads

Kyrle's disease effectively treated with oral isotretinoin.

J Dermatolog Treat 2018 Sep 10;29(6):630-632. Epub 2018 Jan 10.

a Section of Dermatology, Department of Medicine , University of Verona , Verona , Italy.

Background: Kyrle's disease (KD) is a primary perforating dermatosis that affects more commonly 30-50 year old females, and clinically characterized by pruritic hyperkeratotic and ulcerated nodules, papules and plaques, localized on extensor surface of upper and lower limbs, and on the trunk.

Objective: To determine the effectiveness of the treatment with oral isotretinoin in KD.

Methods: We present the case of a 63-year-old woman with hyperkeratotic, erythematous-brown nodules and plaques localized on arms and legs, intensely itching; some lesions were ulcerated and discharging. Read More

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http://dx.doi.org/10.1080/09546634.2017.1422080DOI Listing
September 2018
11 Reads

Kyrle's disease: a cutaneous manifestation of diabetes mellitus.

BMJ Case Rep 2017 Nov 1;2017. Epub 2017 Nov 1.

Endocrinology, Diabetes and Bariatric Medicine, Narayana Health City, Bengaluru, Karnataka, India.

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http://dx.doi.org/10.1136/bcr-2017-220023DOI Listing
November 2017
3 Reads

Acquired perforating dermatosis in a patient with chronic renal failure.

An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):10-13

Universidade Federal do Estado do Rio de Janeiro (UNIRIO) - Rio de Janeiro (RJ), Brazil.

Perforating dermatoses are a group of skin diseases characterized by transepidermal elimination of dermal material. The disease is divided into two groups: the primary group and the secondary group. The classical or primary perforating dermatoses are subdivided into four types according to the eliminated dermal materials: Kyrle disease, perforating reactive collagenosis, elastosis perforans serpiginosa, and perforating folliculitis. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20164619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324979PMC
July 2017
11 Reads

Kyrle's Disease: A Rare Skin Manifestation of Diabetes Mellitus.

J Assoc Physicians India 2016 07;64(7):81-82

Professor, P.G. Department of Medicine, S.N. Medical College, Agra, Uttar Pradesh.

Kyrle's disease is a rare skin disorder which is characterized by hyperkeratotic papules and nodules with a central keratotic plug mostly located in lower limbs. Exact etiology of Kyrle's disease is unknown, but its association has been reported sparsely with renal disorders, uremic patients on dialysis, diabetes mellitus, liver disease and paraneoplastic syndromes, tuberculosis and some fungal diseases. We report Kyrle's disease in a middle aged female suffering from diabetes mellitus with diabetic nephropathy on hemodialysis. Read More

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July 2016
4 Reads

Dermoscopy of Kyrle disease.

J Am Acad Dermatol 2016 Sep;75(3):e99-e101

Dermatology Unit, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.1016/j.jaad.2016.02.1169DOI Listing
September 2016
9 Reads

Successful treatment of Kyrle disease with narrowband ultraviolet B.

J Dermatol 2017 Jun 23;44(6):721-722. Epub 2016 Jul 23.

Department of Dermatology, Hirosaki University School of Medicine, Aomori, Japan.

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http://dx.doi.org/10.1111/1346-8138.13525DOI Listing
June 2017
13 Reads

Kyrle's Disease in a Patient with Delusions of Parasitosis.

Rom J Intern Med 2016 Jan-Mar;54(1):66-9

Acquired perforating disorders are a group of uncommon skin conditions characterized by transepidermal extrusion of altered dermal material, most often associated with diabetes mellitus and chronic kidney failure. Delusional parasitosis is a primary psychiatric disorder in which affected patients have fixed, false beliefs that their skin is infested by parasites, in the absence of any evidence supporting their statements. A 69 year old malepatient addressed the Dermatology Department for a skin eruption consisting of multiple umbilicated keratotic papules with a generalized distribution. Read More

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http://dx.doi.org/10.1515/rjim-2016-0008DOI Listing
July 2016
25 Reads

A Case of Infantile Kyrle-Flegel Disease in a 6-Year-Old Yemeni Girl.

Case Rep Dermatol 2016 Jan-Apr;8(1):5-9. Epub 2016 Jan 20.

Dermatology Department, University Hospital, Sana'a University, Sana'a, Yemen.

Kyrle disease (KD) and Flegel disease (FD) are rare variants of primary perforating dermatoses, characterized by transepidermal elimination of abnormal endogenous materials. We describe a 6-year-old Yemeni girl with a 2-year history of generalized asymptomatic, small, reddish-brown keratotic papules with a lenticular central keratotic plug. Although these features are synonymous with FD, the histology of a punch biopsy was consistent with KD. Read More

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http://dx.doi.org/10.1159/000443824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772611PMC
March 2016
21 Reads

Kyrle Disease A Rare Dermatologic Condition Associated with the Diabetic Foot.

J Am Podiatr Med Assoc 2015 Sep;105(5):451-5

We report two cases of biopsy-confirmed Kyrle disease. Kyrle disease is one of the perforating dermatoses associated with diabetic patients undergoing renal dialysis. In this report, we describe the clinical and histopathologic features, the differential diagnoses, and successful treatment of this unusual disorder. Read More

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http://dx.doi.org/10.7547/14-009DOI Listing
September 2015
2 Reads

Corkscrew hairs.

Cleve Clin J Med 2015 Apr;82(4):216

Department of Dermatology, Division of Dermatopathology and Cutaneous Immunopathology, Mayo Clinic, Rochester, MN, USA. E-mail:

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http://dx.doi.org/10.3949/ccjm.82a.14135DOI Listing
April 2015
2 Reads

Squamous cell carcinoma developed on Kyrle's disease scar.

J BUON 2014 Jan-Mar;19(1):317-8

Dept. of Dermatology, "A. Sygros" Hospital, Athens, Greece.

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May 2014
18 Reads

Clinicopathological features of 25 patients with acquired perforating dermatosis.

Eur J Dermatol 2013 Nov-Dec;23(6):864-71

Dermatology Clinic.

Background: Acquired perforating dermatosis (APD) is a rare group of skin disorders characterized by transepidermal elimination of dermal tissue material. There are only a few studies of APD.

Objective: We aimed to review the clinicopathologic features of patients with APD and evaluate the outcomes of treatments. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ej
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http://dx.doi.org/10.1684/ejd.2013.2237DOI Listing
February 2015
15 Reads

Perforating disorders of the skin.

Indian J Pathol Microbiol 2013 Oct-Dec;56(4):355-8

Department of pathology, K. J. Somaiya Medical College and Research Centre, Mumbai, Maharashtra, India.

Background: Perforating disorders of the skin, is an often overlooked entity characterized by transepidermal elimination of material from the upper dermis and are classified histopathologically according to the type of epidermal disruption and the nature of the eliminated material. They include Kyrle's disease, perforating folliculitis, reactive perforating collagenosis, and elastosis perforans serpiginosa.

Aim: The aim of this study was to delineate the clinical and histopathological features of perforating disorders of the skin. Read More

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http://dx.doi.org/10.4103/0377-4929.125289DOI Listing
June 2014
7 Reads

Kyrle's disease.

BMJ Case Rep 2014 Jan 15;2014. Epub 2014 Jan 15.

Konya Training and Research Hospital, Konya, Turkey.

Kyrle's disease (KD) is a dermatosis which was first described by Kyrle as "hyperkeratosis follicularis et parafollicularis in cutem penetrans" in 1916. Perforating dermatoses are a heterogeneous disorder group characterised by transepithelial elimination. KD has been seen in association with multiple disorders, including diabetes mellitus, renal and liver diseases, congestive heart failure, hyperlipidaemia, infective diseases and abnormal metabolism of vitamin A. Read More

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http://dx.doi.org/10.1136/bcr-2013-009905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903330PMC
January 2014
4 Reads

Kyrle disease and acquired perforating collagenosis secondary to chronic renal failure and diabetes mellitus.

Case Rep Dermatol 2011 Sep 29;3(3):209-11. Epub 2011 Sep 29.

Department of Dermatology, University Hospital Regensburg, Regensburg.

A 59-year-old man with chronic renal failure and diabetes mellitus presented with pruritic crusted lesions which histologically were perforating disorders, showing features of both Kyrle disease and acquired perforating collagenosis. The mechanisms of transepidermal elimination and the classification of perforating disorders are briefly discussed. Additionally, we question the concept of perforation, as epidermal damage and exposure of subepidermal substances may artificially present as perforation. Read More

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http://dx.doi.org/10.1159/000333005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214844PMC
September 2011
4 Reads

Verrucous tuberculid mimicking Kyrle disease.

Int J Dermatol 2007 Dec;46(12):1298-301

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Cutaneous tuberculosis shows wide clinical variation depending upon the virulence of the organism and host immunity. Tuberculids are difficult to diagnose since the organism often cannot be identified or isolated by microscopy, culture or polymerase chain reaction. The diagnosis rests primarily on the identification of a tuberculous focus elsewhere in the body and response to antitubercular therapy. Read More

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http://dx.doi.org/10.1111/j.1365-4632.2007.03374.xDOI Listing
December 2007
3 Reads

Acquired perforating disease associated with chronic renal failure.

Int J Dermatol 1992 Feb;31(2):117-8

Department of Dermatology, Guatemalan Social Security Hospital.

A 48-year-old man, in a chronic hemodialysis program, had numerous skin lesions develop that consisted of follicular papules and small hyperkeratotic nodules, located on the trunk, hips, and upper and lower extremities (where the lesions were more numerous). The nodules measured 3 to 5 mm and had a dark discoloration (Figs 1 and 2). Four months previously, the patient noticed the appearance of disseminated papular and pruritic lesions. Read More

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February 1992
5 Reads

Kyrle disease associated with sarcoidosis and renal failure.

Int J Dermatol 1991 Mar;30(3):211-2

Department of Dermatology, Tokyo University Hospital, Japan.

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March 1991
1 Read

[Kyrle disease--a case report].

Z Hautkr 1990 Sep;65(9):847-50

Abteilung für Dermatologie und Venerologie, Bundeswehrzentralkrankenhaus Koblenz.

Based on a case of our own observation, we present the characteristic features of a rare skin disease: hyperkeratosis follicularis et parafollicularis in cutem penetrans, i.e. Kyrle's disease. Read More

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September 1990
5 Reads

[Kyrle disease in juvenile diabetes mellitus and chronic renal failure].

Z Hautkr 1990 Jan;65(1):53-61

Klinikum Steglitz der Freien Universität Berlin.

We report on a 32-year-old female patient with chronic diabetes mellitus, type I, and chronic renal failure, who developed the typical clinical picture of hyperkeratosis follicularis et parafollicularis in cuteum penetrans (Kyrle's disease) within one year. Histological examination revealed a defective epidermal differentiation with hyper- and parakeratosis as well as premature keratinization as early as in the epidermal basal cell layer. Studies on lectin binding showed that the glycosylation process was impaired in both the epidermis and the basement membrane zone of the lesional skin. Read More

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January 1990
4 Reads

[The Kyrle disease entity and its therapeutic modification by acitretin (etretin)].

Z Hautkr 1989 Apr;64(4):286, 289-91

Zentrum der Dermatologie und Venerologie, Abt. I, J.W. Goethe-Universität, Frankfurt am Main.

We report on a 50-year-old woman having suffered from atypically located Kyrle's disease for 2 years. Especially the palmoplantar areas were affected by keratotic erythematous papules showing the typical histologic picture of Kyrle's disease. Treatment with acitretin (initial dose 30 mg/day) resulted in almost complete remission after 6 months. Read More

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April 1989
8 Reads

[Kyrle disease].

Authors:
M Narwutsch

Dermatol Monatsschr 1989 ;175(8):504-10

In the group of perforating skin diseases with transepithelial elimination the hyperkeratosis follicularis et parafollicularis in cutem penetrans is very rare. By means of casuistics the clinical and histological features are discussed. Re-PUVA as a feasible therapy variant was performed. Read More

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November 1989
10 Reads

[Kyrle disease and transepithelial elimination].

G Ital Dermatol Venereol 1987 Sep;122(9):439-42

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September 1987
3 Reads

Kyrle disease. Treatment with topically applied tretinoin.

Arch Dermatol 1974 Nov;110(5):762-5

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November 1974
5 Reads

[KYRLE'S DISEASE].

Bull Soc Fr Dermatol Syphiligr 1964 Nov-Dec;71:760-1

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December 1996
2 Reads

[DISSEMINATED HYPERKERATOSIS. KYRLE'S DISEASE?].

Bull Soc Fr Dermatol Syphiligr 1964 Jan-Feb;71:82-3

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December 1996
4 Reads

[KYRLE'S "HYPERKERATOSIS FOLLICULARIS ET PARAFOLLICULARIS IN CUTEM PENETRANS"].

Authors:
U MARAGNANI

Minerva Dermatol 1963 Oct;38:318-23

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October 1963
4 Reads

HYPERKERATOSIS PENETRANS (KYRLE'S DISEASE).

Arch Dermatol 1963 Aug;88:210-4

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August 1963
4 Reads

[KYRLE'S DISEASE: SOME ETIOPATHOGENETIC DATA ON A CLINICAL CASE].

Rass Dermatol Sifilogr 1963 May-Jun;16:113-24

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December 1996
3 Reads

Hyperkeratosis penetrans (Kyrle's disease). Report of a case in a Negro with autopsy findings.

Arch Dermatol 1961 Feb;83:277-83

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February 1961
5 Reads

[Kyrle's palmoplantar disease. Role of arsenic in its etiology].

Arch Belg Dermatol Syphiligr 1961 Jan;17:41-6

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January 1961
4 Reads

[A case of Kyrle's disease ("hyperkeratosis follicularis" and "parafollicularis in cutem penertrans")].

Authors:
M AUPAIX R LELOUP

Bull Soc Fr Dermatol Syphiligr 1959 Nov-Dec;5:808-11

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November 1998
2 Reads

[Tuberculosis verrucosa cutis, histologically partially related to follicular changes of Kyrle's disease].

Authors:
H ILLIG

Dermatologica 1959 Apr-May;118(4-5):302-4

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July 2000
8 Reads

[Kyrle's disease].

G Ital Dermatol 1959 Jan-Feb;100:65-91

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November 1998
3 Reads

[Case of Kyrle's disease].

Authors:
M ZANCHI

Rass Dermatol Sifilogr 1957 Jan-Feb;10(1):13-21

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July 2000
4 Reads

[Hyperkeratosis follicularis et parafollicularis in cutem penetrans; case report].

Authors:
W MEYHOFER W KNOTH

Z Haut Geschlechtskr 1956 Mar;20(6):181-4

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March 1956
2 Reads

[Kyrle's disease].

Acta Derm Venereol 1956 ;36(3):167-76

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May 2002
4 Reads

[Kyrle's disease].

Authors:
J R PRAKKEN

Ned Tijdschr Geneeskd 1955 Mar;99(12):903-4

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March 1955
4 Reads

[Hyperkeratosis follicularis et parafollicularis in cutem penetrans (Kyrle's disease)].

Authors:
A GRANA

Soc Ital Dermatol Sifilogr Sezioni Interprov Soc Ital Dermatol Sifilogr 1955 Mar-Apr;96(2):125-41

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May 2003
5 Reads

[Kyrle's disease].

Ann Dermatol Syphiligr (Paris) 1955 Jan-Feb;82(1):8-33

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May 2003
7 Reads