1,753 results match your criteria Kuru

Tranilast for advanced heart failure in patients with muscular dystrophy: a single-arm, open-label, multicenter study.

Orphanet J Rare Dis 2022 May 16;17(1):201. Epub 2022 May 16.

Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.

Background: The transient receptor potential cation channel subfamily V member 2 (TRPV2) is a stretch-sensitive calcium channel. TRPV2 overexpression in the sarcolemma of skeletal and cardiac myocytes causes calcium influx into the cytoplasm, which triggers myocyte degeneration. In animal models of cardiomyopathy and muscular dystrophy (MD), TRPV2 inhibition was effective against heart failure and motor function. Read More

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Validity and Reliability of the Turkish Version of the Sydney Swallow Questionnaire.

Am J Speech Lang Pathol 2022 May 12:1-10. Epub 2022 May 12.

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Prof Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

Purpose: This study aimed to assess the validity and reliability of the Turkish version of the Sydney Swallow Questionnaire (SSQ-T) and calculate a cutoff value to help clinicians to suspect/predict oropharyngeal dysphagia (OPD).

Method: The original questionnaire was translated into Turkish by two bilingual English Turkish translators. The study included 170 Turkish adult subjects. Read More

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Responsiveness and Validity of Weight-Bearing Test for Measuring Loading Capacity in Patients With Triangular Fibrocartilage Complex Injury.

J Sport Rehabil 2022 Apr 23:1-9. Epub 2022 Apr 23.

Faculty of Medicine, Department of Orthopaedics and Traumatology, Baskent University, Ankara,Turkey.

Context: Weight-bearing test (WBT) is a noninvasive quantitative test which has been used recently to determine loading capability of the individuals. The aim of this study was to strengthen the evidence for using the WBT test for measuring weight-bearing capacity of the upper-extremity with the specific objective of examining the internal and external responsiveness and concurrent validity of the test in patients with triangular fibrocartilage complex injury.

Design: Single-group repeated measures. Read More

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An autopsy case of MV2K-type sporadic Creutzfeldt-Jakob disease presenting with characteristic clinical, radiological, and neuropathological findings.

Neuropathology 2022 Apr 19. Epub 2022 Apr 19.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

In Japan, because MV2-type sporadic Creutzfeldt-Jakob disease (CJD) is rare, little is known about its clinical and neuropathological characteristics. An autopsy case of MV2K-type sporadic CJD is presented, and the characteristic clinical, radiological, and neuropathological findings are discussed. The patient was a Japanese woman who died at the age of 72 years. Read More

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Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies.

Brain Pathol 2022 Apr 4:e13069. Epub 2022 Apr 4.

Department of Neuropathology, Institute for Medical Research of Aging, Aichi Medical University, Aichi, Japan.

Subacute sclerotic panencephalitis (SSPE) is a refractory neurological disorder after exposure to measles virus. Recently, SSPE cases have been treated with antiviral therapies, but data on the efficacy are inconclusive. Abnormal tau accumulation has been reported in the brain tissue of SSPE cases, but there are few reports in which this is amply discussed. Read More

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The efficacy of Kinesio taping on lymphedema following head and neck cancer therapy: a randomized, double blind, sham-controlled trial.

Physiother Theory Pract 2022 Mar 28:1-15. Epub 2022 Mar 28.

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Prof Dr Cemil Tascioglu City Hospital, Istanbul, Turkey.

Objective: The aim was to investigate the effectiveness of Kinesio taping for lymphedema following head and neck cancer therapy and its effect on patient compliance and quality of life.

Methods: A total of 66 patients with lymphedema following head and neck cancer therapy were randomly allocated to the therapeutic Kinesio taping group (n = 33) and the sham Kinesio taping group (n = 33). All participants received manual lymphatic drainage, Kinesio taping, and home exercises for the first four weeks, and only home exercises for the second four weeks. Read More

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Impact of Human Papillomavirus on Wnt/Beta-Catenin Signaling in Morphological Inconspicuous Cervicovaginal Cells.

Acta Cytol 2022 Mar 18:1-11. Epub 2022 Mar 18.

Division of Perinatology, Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Introduction: The aim of this study was to identify early changes in the Wnt/beta-catenin signaling pathway in high-risk human papillomavirus (HPV) infected cervicovaginal cells and to correlate these changes with cell proliferation, apoptosis, and autophagic processes.

Methods: We evaluated 91 cervicovaginal smears of women with (n = 41) and without (n = 50) HPV-DNA. Smears were stained against beta-catenin, c-myc, secreted frizzled-related protein 4 (sFRP4), cleaved caspase-3, and the autophagy markers Beclin-1 and light chain 3B. Read More

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Religious affiliation and philosophical and moral beliefs about vaccines: A longitudinal study.

J Health Psychol 2022 Mar 15:13591053221082770. Epub 2022 Mar 15.

University of Pennsylvania, USA.

How do religious affiliation and beliefs shape vaccine attitudes and behaviors? This study examined the associations of attitudes and behaviors relevant to the flu, measles-mumps-rubella (MMR), and human-papillomavirus (HPV) vaccines with religious affiliations, as well as philosophical, spiritual, and moral beliefs. Respondents were 3005 adults from a probability-based, four-wave panel survey in the United States. Longitudinal structural equation modeling examined how religious affiliations and philosophical/moral beliefs shaped attitudes toward vaccines and actual vaccination. Read More

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A New and Alternative Route: Transvaginal Natural Orifice Transluminal Endoscopic Scarless Surgery (vaginal natural orifice transluminal endoscopic surgery) For Class 2 and Class 3 Obese Patients Suffering From Benign and Malignant Gynecologic Pathologies.

Surg Innov 2022 Mar 15:15533506221074628. Epub 2022 Mar 15.

Department of Thoracic Surgery, University of Health Science, Istanbul, Turkey.

This study was conducted to investigate the effectiveness of vaginal natural orifice transluminal endoscopic surgery (vNOTES) gynecologic scarless surgery in benign and malignant class 2 and class 3 obese patients. The class 2 and class 3 obese women undergoing vNOTES scarless surgery for benign and malign indications at a tertiary referral medical center between January 2019 and April 2021 were retrospectively analyzed and surgical outcomes were measured. In this study, 81 class 2 and class 3 obese patients underwent gynecological procedures using vNOTES scarless surgery. Read More

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Comparison of Pain, Muscle Strength, and Functional Status Following Unicompartmental Knee Arthroplasty, Total Knee Arthroplasty, and Conservative Management of Gonarthrosis.

Indian J Orthop 2022 Mar 26;56(3):464-472. Epub 2021 Oct 26.

Department of Physical Medicine and Rehabilitation, Prof. Dr. Cemil Tascioglu City Hospital, University of Health Sciences, Darulaceze Cad. No:25 Okmeydani- Sisli, Istanbul, Turkey.

Background: Treatment options and surgical decision for grade 3-4 gonarthrosis remains controversial. We aimed to compare the pain level, muscle strength, physical performance, lower extremity functions, and other physical activity levels between patients who underwent arthroplasty and those who received conservative management for grade 3-4 gonarthrosis.

Methods: This prospective analytical observational study was conducted in a tertiary referral hospital. Read More

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p(HEMA)-RR241 hydrogel membranes with micron network for IgG depletion in proteomic studies.

J Biomater Sci Polym Ed 2022 Feb 26:1-17. Epub 2022 Feb 26.

Biochemistry Department, Faculty of Science, Ege University, Izmir, Turkey.

Serum proteins can generally be considered a good source for the illness' indication and are precious resources to detect diseases such as inflammation, cancer, diabetes, malnutrition, cardiovascular diseases, Alzheimer's, other autoimmune diseases, and infections. However, one of the biggest difficulties for proteomic studies is that the majority of serum protein mass consists of only a few proteins. Albumin and Immunoglobulin (IgG) constitute 80% of total serum protein. Read More

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February 2022

Different scaling and root planing strategies in Turkish patients with aggressive periodontitis: A randomized controlled clinical trial.

Int J Dent Hyg 2022 May 28;20(2):347-363. Epub 2022 Feb 28.

Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey.

Objectives: The aim of this study was to compare clinical, cytokine and microbiological responses after quadrant-based scaling and root planing (Q-SRP), full-mouth SRP (FM-SRP) and full-mouth disinfection (FMD) in patients with generalized aggressive periodontitis (GAgP), which is currently termed as generalized stage-III and grade-C periodontitis.

Methods: Forty-two patients with GAgP were randomly assigned into groups as Q-SRP, FM-SRP or FMD with chlorhexidine. Clinical parameters were recorded, and gingival crevicular fluid (GCF) and subgingival plaque samples were collected at baseline, 3 and 6 months after treatment. Read More

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Clinical and molecular evaluation of MEFV gene variants in the Turkish population: a study by the National Genetics Consortium.

Funct Integr Genomics 2022 Jan 31. Epub 2022 Jan 31.

Department of Medical Genetics, Faculty of Medicine, Mersin University, Mersin, 33343, Turkey.

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher incidence in the Turkish, Jewish, Arabic, and Armenian populations. As our understanding of FMF improves, it becomes clearer that we are facing with a more complex picture of FMF with respect to its pathogenesis, penetrance, variant type (gain-of-function vs. Read More

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January 2022

Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis.

N Engl J Med 2022 01;386(4):316-326

From the Division of Rheumatology, Mayo Clinic, Rochester, MN (S.R.Y.); the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (D.L.B.); the Division of Rheumatology, University of Nebraska Medical Center, Omaha (T.R.M.); the Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill (G.G.K.); Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas (R.F.); Pfizer, Madrid (J.L.R.); Pfizer, New York (R.G.); Pfizer, Groton, CT (S.M., C.W., K.S.K., C.A.C.); Pfizer, Shanghai, China (Y.S.); and Pfizer, Peapack, NJ (A.B.S.).

Background: Increases in lipid levels and cancers with tofacitinib prompted a trial of major adverse cardiovascular events (MACE) and cancers in patients with rheumatoid arthritis receiving tofacitinib as compared with a tumor necrosis factor (TNF) inhibitor.

Methods: We conducted a randomized, open-label, noninferiority, postauthorization, safety end-point trial involving patients with active rheumatoid arthritis despite methotrexate treatment who were 50 years of age or older and had at least one additional cardiovascular risk factor. Patients were randomly assigned in a 1:1:1 ratio to receive tofacitinib at a dose of 5 mg or 10 mg twice daily or a TNF inhibitor. Read More

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January 2022

Phylostat: a web-based tool to analyze paralogous clade divergence in phylogenetic trees.

Turk J Biol 2021 14;45(6):667-673. Epub 2021 Dec 14.

Molecular Biology, Genetic and Bioengineering, Faculty of Engineering and Natural Sciences, Sabancı University, İstanbul Turkey.

Phylogenetic trees are useful tools to infer evolutionary relationships between genetic entities. Phylogenetics enables not only evolution-based gene clustering but also the assignment of gene duplication and deletion events to the nodes when coupled with statistical approaches such as bootstrapping. However, extensive gene duplication and deletion events bring along a challenge in interpreting phylogenetic trees and require manual inference. Read More

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December 2021

Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis.

Neurobiol Aging 2022 05 11;113:131-136. Epub 2021 Dec 11.

Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

DNAJC7 has recently been identified as an amyotrophic lateral sclerosis (ALS) gene via large-scale exome analysis, and its involvement in ALS is still unclear in various populations. This study aimed to determine the frequencies and characteristics of the DNAJC7 variants in a Japanese ALS cohort. A total of 807 unrelated Japanese patients with sporadic ALS were screened via exome analysis. Read More

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DeepSide: A Deep Learning Approach for Drug Side Effect Prediction.

IEEE/ACM Trans Comput Biol Bioinform 2022 Jan 7;PP. Epub 2022 Jan 7.

Drug failures due to unforeseen adverse effects at clinical trials pose health risks for the participants and lead to substantial financial losses. Side effect prediction algorithms have the potential to guide the drug design process. LINCS L1000 dataset provides a vast resource of cell line gene expression data perturbed by different drugs and creates a knowledge base for context specific features. Read More

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January 2022

Explaining Health Misinformation Belief through News, Social, and Alternative Health Media Use: The Moderating Roles of Need for Cognition and Faith in Intuition.

Health Commun 2022 Jan 3:1-14. Epub 2022 Jan 3.

Department of Media and Visual Arts, Koc University.

Explaining the spread and impact of health misinformation has garnered considerable attention with the uptake of social media and group messaging applications. This study contributes to that line of work by investigating how reliance on multiple digital media may help support or suppress misinformation belief, and how individual differences in misinformation susceptibility condition this process. Alternative health outlets ( media), advocating home/homeopathic remedies over conventional medicine can be important sources of misinformation, yet are largely ignored previously. Read More

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January 2022

Effects of L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats with a High Fat-Diet.

Turk J Ophthalmol 2021 Dec;51(6):344-350

Marmara University Faculty of Dentistry, Department of Basic Medical Sciences-Biochemistry, İstanbul, Turkey.

Objectives: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. Read More

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December 2021

Differential Accumulation of Misfolded Prion Strains in Natural Hosts of Prion Diseases.

Viruses 2021 12 7;13(12). Epub 2021 Dec 7.

Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, 1800 Christensen, Ames, IA 50011, USA.

Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are a group of neurodegenerative protein misfolding diseases that invariably cause death. TSEs occur when the endogenous cellular prion protein (PrP) misfolds to form the pathological prion protein (PrP), which templates further conversion of PrP to PrP, accumulates, and initiates a cascade of pathologic processes in cells and tissues. Different strains of prion disease within a species are thought to arise from the differential misfolding of the prion protein and have different clinical phenotypes. Read More

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December 2021

Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo-optico-neuropathy (SMON).

Mol Genet Genomic Med 2022 01 24;10(1):e1845. Epub 2021 Dec 24.

Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu University, Gifu, Japan.

Background: Subacute myelo-optico-neuropathy (SMON) is a severe neurological disorder associated with clioquinol administration, which frequently occurred in Japan during the 1950s and 1960s. The unique genetic background of the Japanese population is considered to be strongly involved in the development of this neurological disease. Recently, genetic variants of ABCC4 (OMIM: 605250) and ABCC11 (OMIM: 607040), which are particularly common in the Japanese population, were suggested as possible genetic susceptibility factors for the development of SMON. Read More

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January 2022

Characteristics of myotonic dystrophy patients in the national registry of Japan.

J Neurol Sci 2022 Jan 11;432:120080. Epub 2021 Dec 11.

Clinical Neurophysiology, Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

Myotonic dystrophies (DM) are inherited autosomal dominant disorders affecting multiple organs. Currently available therapeutics for DM are limited; therefore, a patient registry is essential for therapeutic development and success of clinical trials targeting the diseases. We have developed a nationwide DM registry in Japan under the Registry of Muscular Dystrophy (Remudy). Read More

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January 2022

A Review of Infectious Diseases Associated with Religious and Nonreligious Rituals.

Interdiscip Perspect Infect Dis 2021 6;2021:1823957. Epub 2021 Dec 6.

Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Rituals are an integral part of human life but a wide range of rituals (both religious and non-religious), from self-flagellation to blood brotherhood to ritual sprinkling of holy water, have been associated with transmission of infections. These infections include angiostrongyliasis, anthrax, brucellosis, cholera, COVID-19, cutaneous larva migrans, Ebola, hepatitis viruses, herpes simplex virus, HIV, human T-cell leukemia virus (HTLV), kuru, , meningoencephalitis, orf, rift valley fever, and sporotrichosis. Education and community engagement are important cornerstones in mitigating infectious risks associated with rituals. Read More

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December 2021

A Comparative Evaluation of Root Surface Biomodification with Erbium-Doped Yttrium Aluminum Garnet Laser, Ethylenediaminetetraacetic Acid Gel, and Titanium Nitride Curette: Scanning Electron Microscope and Profilometry Analyses.

Photobiomodul Photomed Laser Surg 2021 Dec;39(12):766-773

Faculty of Dentistry, Department of Periodontology, Yeditepe University, Istanbul, Turkey.

This study aims to evaluate the effects of different biomodification treatment methods on extracted tooth/root surfaces in terms of biologically acceptable changes favoring better periodontal healing. The use of various agents for root surface biomodification (RSB), during periodontal procedures is of critical importance to increase the success of the treatments through healing. Ethylenediaminetetraacetic acid (EDTA) is the most frequently used chemical RSB agent in periodontal clinical practice. Read More

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December 2021

Biased perceptions against female scientists affect intentions to get vaccinated for COVID-19.

Public Underst Sci 2022 02 1;31(2):239-251. Epub 2021 Dec 1.

Koç University, Turkey.

Based on role congruity theory, we investigated how gender bias may influence public attitudes toward the vaccine in Turkey. Using a between-subjects design, we tested whether an emphasis on the female versus the male scientist as the vaccine's inventor in a news story influenced attitudes about the BioNTech vaccine and vaccination intentions. Partly confirming role congruity theory, three-way interaction results from 665 participants demonstrated that among male participants with a stronger belief in traditional gender roles (compared to males with lower belief), the presence of the female inventor, either by herself or together with the male inventor, decreased the perceived efficacy and safety of the vaccine and reduced intentions to be vaccinated by the BioNTech vaccine. Read More

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February 2022

Persistent infection of Mycobacterium tuberculosis in a patient with Behçet's disease after rotator cuff repair surgery: A case report.

Jt Dis Relat Surg 2021 19;32(3):786-791. Epub 2021 Nov 19.

Başkent Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, 06490 Bahçelievler, Ankara, Türkiye.

Tuberculosis (TB) infection is a common health problem in low socioeconomic populations in developing countries. Osteoarticular TB is a disease that rarely occurs outside the vertebral column and is often diagnosed late or misdiagnosed, particularly in non-weight bearing joints. A 51-year-old female patient with Behçet's disease presented with shoulder TB following rotator cuff repair surgery, leading to joint resection as a result of recurrent infections with no reproduction in culture samples due to delayed diagnosis. Read More

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November 2021

Johnwellsia, a new intertidal genus of Parastenheliidae (Copepoda, Harpacticoida) from the Taiwan Strait, China, including a review of the family and key to genera.

Zootaxa 2021 Oct 12;5051(1):236-318. Epub 2021 Oct 12.

College of Marine Life Science, Ocean University of China, 5 Yushan Road, Qingdao 266003, China. .

A new genus of Parastenheliidae, Johnwellsia gen. nov., is proposed for its type and only species, J. Read More

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October 2021

Kinesiophobia and its association with treatment choice in individuals with idiopathic scoliosis.

J Back Musculoskelet Rehabil 2021 Oct 29. Epub 2021 Oct 29.

School of Physical Therapy and Rehabilitation, Faculty of Health Sciences, Hasan Kalyoncu University, Gaziantep, Turkey.

Background: Previous studies have reported increased kinesiophobia in adults with degenerative scoliosis or adolescents who have undergone spinal surgery. However, little is known about the phenomenon of kinesiophobia among adolescents with idiopathic scoliosis (IS).

Objectives: The aim of this study was to investigate levels of kinesiophobia and its association with treatment choice in IS. Read More

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October 2021

Treatment of residual pockets using an oscillating chitosan device versus regular curettes alone-A randomized, feasibility parallel-arm clinical trial.

J Periodontol 2022 May 21;93(5):780-789. Epub 2021 Dec 21.

Department of Periodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.

Background: A brush made of chitosan has shown to be an effective and harmless device for non-surgical treatment of mild to moderate peri-implantitis. To date, no study has evaluated the use of a chitosan brush in the non-surgical treatment of residual pockets in periodontal treatment.

Methods: Seventy-eight patients with periodontitis were included in this multicenter, randomized, examiner-blind clinical trial of 6 months duration. Read More

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