1,690 results match your criteria Kuru

Comparison of five thyroid ultrasound stratification systems for differentiation of benign and malignant nodules and to avoid biopsy using histology as reference standard.

Endocr Pract 2021 Apr 27. Epub 2021 Apr 27.

Department of Radiology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.

Objective: We aimed at to compare the thyroid ultrasound risk stratification systems (RSSs) of the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS), European (EU) TI-RADS, Korean (K) TI-RADS, and American Thyroid association (ATA) guidelines and American Association of Clinical Endocrinologists (AACE), American College of Endocrinology (ACE) and Associazione Medici Endocrinologi (AME) guidelines to differentiate benign from malignant thyroid nodules and to avoid unnecessary FNA.

Methods: The records of 1143 nodules ≥1 cm which underwent fine needle aspiration biopsy (FNA) and thyroidectomy between 2012 and 2020 at our institution were reviewed. Ultrasound categories and FNA recommendation indications of five international RSSs were compared with histopathological finding as benign or malignant. Read More

View Article and Full-Text PDF

Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo.

Nat Commun 2021 04 22;12(1):2369. Epub 2021 Apr 22.

Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.

Photoactivatable molecules enable ablation of malignant cells under the control of light, yet current agents can be ineffective at early stages of disease when target cells are similar to healthy surrounding tissues. In this work, we describe a chemical platform based on amino-substituted benzoselenadiazoles to build photoactivatable probes that mimic native metabolites as indicators of disease onset and progression. Through a series of synthetic derivatives, we have identified the key chemical groups in the benzoselenadiazole scaffold responsible for its photodynamic activity, and subsequently designed photosensitive metabolic warheads to target cells associated with various diseases, including bacterial infections and cancer. Read More

View Article and Full-Text PDF

Triggers and oncologic outcome of salvage radical prostatectomy, salvage radiotherapy and active surveillance after focal therapy of prostate cancer.

World J Urol 2021 Apr 21. Epub 2021 Apr 21.

Clinic of Urology, Urooncology, Robotic-Assisted and Focal Therapy, Medical Faculty and University Clinics of Magdeburg, Magdeburg, Germany.

Purpose: Due to the tissue preserving approach of focal therapy (FT), local cancer relapse can occur. Uncertainty exists regarding triggers and outcome of salvage strategies.

Methods: Patients with biopsy-proven prostate cancer (PCa) after FT for localized PCa from 2011 to 2020 at eight tertiary referral hospitals in Germany that underwent salvage radical prostatectomy (S-RP), salvage radiotherapy (S-RT) or active surveillance (AS) were reported. Read More

View Article and Full-Text PDF

Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options.

Updates Surg 2021 Apr 11. Epub 2021 Apr 11.

Department of Endocrinology and Metabolism, School of Medicine, Koc University, Istanbul, Turkey.

Purpose: The COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic. Read More

View Article and Full-Text PDF

The effects of scientific messages and narratives about vaccination.

PLoS One 2021 24;16(3):e0248328. Epub 2021 Mar 24.

Department of Psychology, University of Illinois, Champaign, Illinois, United States of America.

A fundamental challenge complicates news decisions about covering vaccine side effects: although serious vaccine side effects are rare, less severe ones do occur occasionally. The study was designed to test whether a side effect message could induce vaccine hesitancy and whether that could be countered by pro-vaccine messages about vaccine safety. A large (N = 2,345), nationally representative experiment was conducted by randomly exposing participants to one of six videos about the measles, mumps, and rubella (MMR) vaccine edited from news programs produced during the 2019 measles outbreak in the United States. Read More

View Article and Full-Text PDF

[Changing medical care for amyotrophic lateral sclerosis patients and cause of death - review of muscular dystrophy wards (1999-2013)].

Rinsho Shinkeigaku 2021 Mar 23;61(3):161-165. Epub 2021 Feb 23.

Department of Neurology, National Hospital Organization Higashisaitama National Hospital.

We analyzed the records of inpatients with amyotrophic lateral sclerosis (ALS) treated at 27 specialized institutions for muscular dystrophy in Japan from 1999 to 2013 registered in a database on October 1 of each year. The total number of ALS inpatients in 1999 was 29, then that showed rapid increases in 2006 and 2007, and reached 164 in 2013. Age regardless of year was predominantly greater than 50 years. Read More

View Article and Full-Text PDF

[Psychosocial effects of the pandemic on staff and residents of nursing homes as well as their relatives-A systematic review].

Z Gerontol Geriatr 2021 Mar 23;54(2):141-145. Epub 2021 Feb 23.

Netzwerk Alternsforschung (NAR), Universität Heidelberg, Bergheimer Str. 20, 69115, Heidelberg, Deutschland.

Background: Following the COVID-19 pandemic residents of nursing homes, their visitors and families as well as employees are faced with new challenges. Protective measures have a strong impact on the well-being of all these groups of persons.

Material And Methods: A systematic search was carried out for studies investigating the psychosocial consequences of the COVID-19 pandemic for residents, their visitors and families as well as nursing home staff. Read More

View Article and Full-Text PDF

[Fifity years after the identification of the cause of SMON].

Satoshi Kuru

Rinsho Shinkeigaku 2021 Feb 26;61(2):109-114. Epub 2021 Jan 26.

Department of Neurology, National Hospital Organization Suzuka Hospital.

SMON (subacute myelo-optico-neuropathy) is toxic neurological disease which had a profound impact on the population in Japan in 1960's. The clinical characteristics of SMON includes an ascending sensory disturbance, spasticity, and visual impairment typically following abdominal symptoms. Infection was first suspected as an underlying cause of this epidemic. Read More

View Article and Full-Text PDF
February 2021

The level of two trace elements in carious, non-carious, primary, and permanent teeth.

Eur Oral Res 2020 May;54(2):77-80

Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University,Istanbul,Turkey.

Purpose: The boron and fluoride mainly accumulate in the bones and teeth of the human body. The purpose of this study is to determine boron or fluoride levels in the whole tooth, to evaluate the correlation between their levels and to compare these levels in primary/permanent, carious, and non-carious groups.

Materials And Methods: The boron and fluoride levels of thirty-six teeth, separated such as primary carious (n=9) and non-carious (n=9), permanent carious (n=9) and non-carious (n=9), were determined by ICP-MS and ion-selective electrode, respectively. Read More

View Article and Full-Text PDF

Is the extent of lymphadenectomy a prognostic factor in International Federation of Gynecology and Obstetrics stage II endometrioid endometrial cancer?

J Obstet Gynaecol Res 2021 Mar 10;47(3):1134-1144. Epub 2021 Jan 10.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Baskent University, Ankara, Turkey.

Aim: This study aimed to evaluate the prognostic significance of adequate lymph node dissection (LND) (≥10 pelvic lymph nodes (LNs) and ≥ 5 paraaortic LNs removed) in patients with International Federation of Gynecology and Obstetrics (FIGO) stage II endometrioid endometrial cancer (EEC).

Methods: A multicenter department database review was performed to identify patients who had been operated and diagnosed with stage II EEC at seven centers in Turkey retrospectively. Demographic, clinicopathological, and survival data were collected and analyzed. Read More

View Article and Full-Text PDF

Immune alterations in subacute sclerosing panencephalitis reflect an incompetent response to eliminate the measles virus.

PLoS One 2021 7;16(1):e0245077. Epub 2021 Jan 7.

Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

In subacute sclerosing panencephalitis (SSPE) the persistence of measles virus (MeV) may be related to the altered immune response. In this study, cytokine responses of lymphocytes and monocytes were evaluated in SSPE compared to controls with non-inflammatory (NICON) and inflammatory (ICON) diseases. Patients with SSPE (n = 120), 78 patients with ICON and 63 patients with NICON were included in this study. Read More

View Article and Full-Text PDF

The Whiteness of Bioethics.

Warwick Anderson

J Bioeth Inq 2021 Mar 4;18(1):93-97. Epub 2021 Jan 4.

Department of History and Charles Perkins Centre, University of Sydney, SOPHI, Quadrangle A14, Sydney, NSW, 2006, Australia.

A discussion of whiteness as an "ethos" or "relational category" in bioethics, drawing on examples from medical and historical research. Read More

View Article and Full-Text PDF

Extracellular Amyloid Deposits in Alzheimer's and Creutzfeldt-Jakob Disease: Similar Behavior of Different Proteins?

Int J Mol Sci 2020 Dec 22;22(1). Epub 2020 Dec 22.

Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer Hospital, 100 00 Prague, Czech Republic.

Neurodegenerative diseases are characterized by the deposition of specific protein aggregates, both intracellularly and/or extracellularly, depending on the type of disease. The extracellular occurrence of tridimensional structures formed by amyloidogenic proteins defines Alzheimer's disease, in which plaques are composed of amyloid β-protein, while in prionoses, the same term "amyloid" refers to the amyloid prion protein. In this review, we focused on providing a detailed didactic description and differentiation of diffuse, neuritic, and burnt-out plaques found in Alzheimer's disease and kuru-like, florid, multicentric, and neuritic plaques in human transmissible spongiform encephalopathies, followed by a systematic classification of the morphological similarities and differences between the extracellular amyloid deposits in these disorders. Read More

View Article and Full-Text PDF
December 2020

Oestrus Synchronisation with Progesterone-containing Sponge and Equine Chorionic Gonadotropin in Pirlak Ewes During the Non-breeding Season: Can Toryum Improve Fertility Parameters?

J Vet Res 2020 Dec 6;64(4):573-579. Epub 2020 Nov 6.

Department of Animal Breeding and Husbandry, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey.

Introduction: The aim of the study was to determine the effect of the vitamins, omega-3 polyunsaturated fatty acid and minerals in the supplement Toryum administered before and during oestrus synchronisation on some fertility parameters of ewes during the non-breeding season.

Material And Methods: The experimental animals were clinically healthy Pirlak ewes, 55-75 days postpartum, aged 2-4 years and weighing 40-50 kg. A sponge was inserted into the vagina for 10 d (G1, n = 30; G2, n = 30) or 14 d (G3, n = 30; G4, n = 30) for oestrus synchronisation, and on the day of removal, 400 IU equine chorionic gonadotropin was injected. Read More

View Article and Full-Text PDF
December 2020

The wide-ranging clinical and genetic features in Japanese families with valosin-containing protein proteinopathy.

Neurobiol Aging 2021 Apr 14;100:120.e1-120.e6. Epub 2020 Nov 14.

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. Electronic address:

Mutations in the valosin-containing protein (VCP) gene are known to cause various neurodegenerative disorders. Here, we report 8 Japanese patients [6 men, 2 women; median age at onset: 49.5 (range, 35-58) years] from 5 unrelated families with VCP missense mutations. Read More

View Article and Full-Text PDF

Antler cannibalism in reindeer.

Sci Rep 2020 12 17;10(1):22168. Epub 2020 Dec 17.

Norwegian Institute for Nature Research (NINA), Torgarden, P. O. Box 5685, 7485, Trondheim, Norway.

Prion diseases constitute a class of invariably fatal and degenerative encephalopathies. Chronic Wasting Disease (CWD) is a contagious prion disease among cervids, which is spreading and causing marked population declines in USA and Canada. The first outbreak of CWD in Europe was discovered in a reindeer population in Norway in 2016. Read More

View Article and Full-Text PDF
December 2020

Retrospective Analysis of Pure Ovarian Immature Teratoma in Patients Aged 15-39 Years: A Turkish Multicenter Study.

J Adolesc Young Adult Oncol 2020 Dec 9. Epub 2020 Dec 9.

Division of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey.

To evaluate the clinicopathological characteristics and surgical outcomes in patients with pure ovarian immature teratomas (POITs). In this multicenter study, a retrospective review was made of the databases of six Gynecology Oncology Departments in Turkey to identify patients with POITs who had undergone surgery between 1993 and 2019. Evaluation was made of 48 patients with a median age at diagnosis of 22. Read More

View Article and Full-Text PDF
December 2020

Efficacy of a commercial test kit to determine early pregnancy in cows using whole blood and blood serum.

Trop Anim Health Prod 2020 Nov 23;53(1):28. Epub 2020 Nov 23.

Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey.

The objective of this study was to determine the efficacy of the Fassisi®BoviPreg visual test kit (Fassisi®BoviPreg) in determining early pregnancies in cows by measuring the pregnancy-associated glycoprotein (PAG) in whole blood and blood serum. The study was conducted on 50 cows, the artificial insemination (AI) dates of which were designated as day 0. Pregnancy diagnosis was performed with transrectal ultrasonography (USG), and serum samples were simultaneously collected and used with Fassisi®BoviPreg to determine pregnancies on 30 days after AI. Read More

View Article and Full-Text PDF
November 2020

Cytoreductive surgery including distal pancreatectomy with splenectomy in advanced stage ovarian cancer: Two centers analysis.

Taiwan J Obstet Gynecol 2020 Nov;59(6):862-864

Hacettepe University, Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, Ankara, Turkey.

Objective: Complex procedures such as distal pancreatectomy and splenectomy (DPS) may be required for R0 resection in patients with ovarian cancer (OC). These procedures can increase survival and cause serious morbidity. We aimed to present our experience in this field. Read More

View Article and Full-Text PDF
November 2020

A systematic review of the effect of laughter yoga on physical function and psychosocial outcomes in older adults.

Complement Ther Clin Pract 2020 Nov 28;41:101252. Epub 2020 Oct 28.

Internal Medicine Nursing Department, Faculty of Nursing, Hacettepe University, Ankara, Turkey. Electronic address:

Background: Laughter yoga is one of the increasingly used methods among complementary health approaches in the world. The aim of this study was to determine the effectiveness of laughter yoga on physical function and psychosocial outcomes in older adults.

Methods: In this systematic review, electronic searches were performed in CINAHL, Web of Science, COCHRANE, Scopus, ProQuest databases from May 2010 to May 2020. Read More

View Article and Full-Text PDF
November 2020

Practical applications of brief screening questionnaires for autism spectrum disorder in a psychiatry outpatient setting.

Int J Methods Psychiatr Res 2020 Nov 20:e1857. Epub 2020 Nov 20.

Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Japan.

Objectives: This study was designed to examine the diagnostic performance of the social and communication disorders checklist (SCDC) and strength and difficulties questionnaire (SDQ) to detect autism spectrum conditions (ASC), along with the social responsiveness scale-second edition (SRS-2) as reference, in a psychiatry outpatient setting.

Methods: We translated the SCDC into Japanese since its Japanese version was unavailable. We examined its test-retest reliability as well as the internal consistency reliability and diagnostic performance of the three questionnaires among 41 Japanese psychiatric outpatients, using the best-estimate diagnosis of ASC based on the diagnostic interview for social and communication disorders, as a gold standard. Read More

View Article and Full-Text PDF
November 2020

Effects of different pulp-capping materials on cell death signaling pathways of lipoteichoic acid-stimulated human dental pulp stem cells.

Odontology 2021 Apr 18;109(2):547-559. Epub 2020 Nov 18.

Department of Medical Biochemistry, Faculty of Medicine, University of Istanbul Aydın, Istanbul, Turkey.

Purpose: This study aimed to evaluate the response of dental pulp stem cells (DPSCs) cultured with and without lipoteichoic acid (LTA) to different pulp-capping materials.

Methods: The cells were cultured and seeded in 6-well plates and exposed to 1% LTA solution. Dycal, ProRoot MTA and Biodentine materials were applied on cells and all groups were evaluated by cell proliferation, viability, cell cycle and cell death signaling pathways for 24 and 72 h. Read More

View Article and Full-Text PDF

A case of unusual presentation of acute esophageal necrosis with pneumonia.

Int J Health Sci (Qassim) 2020 Nov-Dec;14(6):66-68

Department of Internal Medicine, St. Joseph's University Medical Center, New Jersey, United States.

Acute esophageal necrosis (AEN) is a rare and often fatal pathology of unclear etiology affecting the distal two-thirds of the esophagus. Typically, elderly patients with multiple comorbidities present with signs of upper gastrointestinal (GI) hemorrhage. On endoscopy, the mucosa is black due to ischemic necrosis, resulting in the commonly used term "black esophagus. Read More

View Article and Full-Text PDF
November 2020

The effects of systemic ozone application and hyperbaric oxygen therapy on knee osteoarthritis: an experimental study in rats.

Int Orthop 2021 02 13;45(2):489-496. Epub 2020 Nov 13.

Faculty of Medicine, Orthopedics and Traumatology, Çanakkale Onsekiz Mart University, Canakkale, Turkey.

Objective: To evaluate the effects of systemic medical ozone (O) application and hyperbaric oxygen (HBO) therapy on surgically induced knee osteoarthritis (OA) in a rat model.

Materials And Methods: We performed anterior cruciate ligament transection (ACLT) in order to create experimental OA in the right knees of 27 male rats. The left knee joints of all rats were sham-operated without ACLT as the negative control group. Read More

View Article and Full-Text PDF
February 2021

Reticular Pruritic Rash: A Quiz.

Acta Derm Venereol 2020 Nov 12;100(18):adv00321. Epub 2020 Nov 12.

Department of Dermatology, University Hospital of Oulu, and Medical Research Center, PEDEGO Research Group, University of Oulu, 90220 Oulu, Finland.

View Article and Full-Text PDF
November 2020

A tribute to the late Professor Donald Simpson, Australian neurosurgeon and namesake of the Simpson grading system for meningioma extent of resection.

J Neurosurg 2020 Oct 23:1-7. Epub 2020 Oct 23.

Donald Simpson (1927-2018) was a neurosurgeon from Adelaide, Australia, who is often cited for the 1957 publication he wrote as a trainee on the relationship between extent of resection and outcomes for meningiomas. That paper summarized a series of over 300 patients operated on in England by well-known neurosurgeons Sir Hugh Cairns and Joseph Buford Pennybacker. Simpson was also known later in his career, when he was at the University of Adelaide in South Australia, for his contributions to the areas of hydrocephalus, spina bifida, craniofacial anomalies, head injury, brain abscesses, and neurosurgical history, and he published extensively on these topics. Read More

View Article and Full-Text PDF
October 2020

Modified C1 lateral mass screw insertion using a threaded K-wire. A technical note.

J Clin Neurosci 2020 Sep 5;79:95-99. Epub 2020 Aug 5.

Department of Orthopaedics, John Hunter Hospital, Lookout Road, New Lambton Heights, NSW 2305, Australia.

Instrumented fixation of the C1-C2 motion segment is a standard surgical technique to stabilise that spinal segment. Instability at C1-C2 can arise from a number of conditions. Fixation of the C1 lateral mass usually involves dissection and exposure of the C2 nerve root and the posterior wall of the C2 lateral mass which can result in significant bleeding from the venous plexus. Read More

View Article and Full-Text PDF
September 2020

Evaluation of Emotional Adverse Effects of Antidepressants: A Follow-up Study.

J Clin Psychopharmacol 2020 Nov/Dec;40(6):594-598

Department of Psychiatry, Manisa Celal Bayar University Hospital, Manisa, Turkey.

Purpose/background: Emotional adverse effects due to antidepressant use may cause difficulties for the clinician in the treatment of depression. In this prospective study, the emotional adverse effects of antidepressants were evaluated in various aspects.

Methods/procedures: Ninety eight patients diagnosed with major depressive disorder were included in the study. Read More

View Article and Full-Text PDF
October 2020

Does ovarian preservation have an effect on recurrence of early stage low-grade endometrial stromal sarcoma?

J Obstet Gynaecol 2020 Oct 16:1-6. Epub 2020 Oct 16.

Department of Gynecologic Oncology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.

Surgical treatment of low-grade endometrial stromal sarcoma consists of hysterectomy. The role of oophorectomy is yet to be established. We aimed to examine the effect of preserving the ovaries on the pattern of recurrences in patients with stage I disease. Read More

View Article and Full-Text PDF
October 2020