1,838 results match your criteria Kuru

The prognostic significance of the heterologous component in uterine carcinosarcomas.

Rev Assoc Med Bras (1992) 2023 18;69(9):e20230517. Epub 2023 Sep 18.

Istanbul University, Cerrahpasa Faculty of Medicine, Department of Gynecological Oncology - Istanbul, Turkey.

Objective: Uterine carcinosarcomas are aggressive, rare biphasic tumors with malignant epithelial and malignant sarcomatous components. The prognostic significance of the presence of extrauterine sarcoma (heterologous component) is controversial. Therefore, the aim of this study was to investigate the effect of heterologous components in uterine carcinosarcomas on disease-free survival, overall survival, and other prognostic factors. Read More

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September 2023

First Record, Distribution and Occurrence of A Protistan Entomopathogen, Perez (Coccidia: Adeleidae) in the Indian Meal Moth, (Hübner) (Lepidoptera: Pyralidae) Populations in Türkiye.

Turkiye Parazitol Derg 2023 Sep;47(3):151-155

Ordu University Faculty of Arts and Science, Department of Molecular Biology and Genetic, Ordu, Türkiye.

Objective: (Hübner) (Lepidoptera: Pyralidae) originating from South America is one of the important insect pests that damages storage products and is found on every continent. There is a new interest in using enthomopathogens for microbial control of as well as other stored product pests. Coccidia as a group of protistan entomopathogens are host specific and their pathogenic effects on the hosts are more pronounced. Read More

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September 2023

Comparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal model.

Saudi Med J 2023 Sep;44(9):864-869

From the Department of Thoracic Surgery (Kuru, Altinok); from the Department of Pathology (Esen), Medical Faculty of Meram, Necmettin Erbakan University, Konya, and from the Department of Thoracic Surgery (Metin), Kayseri City Hospital, Kayseri, Turkey.

Objectives: To investigate the positive effects of intraperitoneal administration of alpha-lipolic acid (ALA) and dexpanthenol (DXP) on wound healing after tracheal surgery in rats.

Methods: The study was carried out at Necmettin Erbakan University, Konya, Turkey, from January 2014-2019. A total of 30 healthy and adult Sprague-Dawley type female rats were included in the study. Read More

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September 2023

A Theoretical Framework on the Biology of Prion Diseases.

Acta Inform Med 2023 Jun;31(2):141-145

Faculty of Medicine, University of Medicine in Tirana, Albania.

Background: Prion diseases or TSE diseases are a group of neurodegenerative disorders that manifest in several forms in humans, such as Kuru disease, Creutzfeldt‒Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS) and fatal familial insomnia.

Objective: In this study, we propose a multimodular hypothesis of prion diseases. According to this hypothesis, a prion disease manifests because of the interaction of two genetic modules, such as the PRNP gene module and that of the gene or genes responsible for one or more chaperones, with one or some chemical module on whose structure the products of the genes or genetic modules interact. Read More

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[Polypharmacy and medication review in the context of prehabilitation].

Urologie 2023 Sep 8. Epub 2023 Sep 8.

Curos urologisches Zentrum, Köln, Abteilung für Urologie, Klinik Links vom Rhein, Köln, Deutschland.

Against the background of typical geriatric multimorbidity and with the particular vulnerability of geriatric patients, polypharmacy deserves special attention. In accordance with the guidelines, medication should not only be reviewed regularly, but also on an ad hoc basis and with each hospital stay-and also in the context of prehabilitation. Thus, not only substances that interfere with the currently planned intervention, anesthesia, or risk of bleeding should be considered, but any medication that increases common risks for geriatric patients. Read More

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September 2023

[Not Available].

Nicolas Senn

Rev Med Suisse 2023 Sep;19(840):1636

Département de médecine de famille, Unisanté, Lausanne.

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September 2023

Novel histotypes of sporadic Creutzfeldt-Jakob disease linked to 129MV genotype.

Acta Neuropathol Commun 2023 Aug 31;11(1):141. Epub 2023 Aug 31.

Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.

The MV1 and MV2 subtypes of sporadic Creutzfeldt-Jakob disease (sCJD) are linked to the heterozygous methionine (M)/valine (V) polymorphism at codon 129 of the prion protein (PrP) gene. MV2 is phenotypically heterogeneous, whereas MV1, due to its low prevalence, is one of the least well characterized subtypes. In this study, we investigated the biochemical properties of PrP and phenotypic expression of cases diagnosed as sCJD MV1 and MV2. Read More

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Two-Point Discrimination in Feet with Ankle Sprains.

J Am Podiatr Med Assoc 2023 Aug 18:1-52. Epub 2023 Aug 18.

*Yozgat Bozok University, Orthopaedics and Traumatology, Yozgat, Turkey.

Background: This study aimed to compare two-point discrimination in feet with ankle sprains and feet without ankle problems, and to determine whether there was a change in the two-point discrimination values in ankle sprains.

Methods: A total of 108 people were included in the study. These subjects were aged between 18 and 40 years and visited the Medical Faculty of Yozgat Bozok University for various reasons in July and September of 2022. Read More

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Evaluation Of YouTube Information Quality About Pes Planus.

J Am Podiatr Med Assoc 2023 Aug 18:1-20. Epub 2023 Aug 18.

†Çanakkale Onsekiz Mart University, Orthopaedics and Traumatology, Çanakkale, Turkey.

Background: The aim of this study is to measure the quality of information about 'flatfoot' and 'pes planus' presented online on the social media site YouTube and to determine the trends of viewers to medical information on YouTube.

Methods: 'flatfoot and pes planus' was typed into the YouTube search module. From the search results, videos with 50000 views or more, longer than 45 seconds, containing information about flatfoot and pes planus disease were selected. Read More

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Biomechanical effect of ankle ligament injury in AO 44B2.1 lateral malleolus fractures after lateral plate fixation: A finite element analysis.

J Am Podiatr Med Assoc 2023 Aug 18:1-31. Epub 2023 Aug 18.

*Yozgat Bozok University, Orthopaedics and Traumatology, Yozgat, Turkey.

Background: Distal fibula fractures at the ankle level are common and are usually accompanied by ligament injuries. This study aims to evaluate the effects of ankle ligament ruptures on ankle joints, fracture instability, and plate stress after distal fibula fracture fixed with plate created by finite element analysis (FEA) modeling and loading applied to ligament rupture models that may accompany this fracture.

Methods: A finite element model consisting of 3-D (3D) fibula, tibia, foot bones, and ankle ligaments was designed to investigate the effects of ligament injuries accompanying plate-detected Arbeitsgemeinschaft für Osteosynthesefragen (AO 44B2. Read More

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Computational mechanical analysis of AO 44 A1, B1 and C1 fracture with Finite Element: Evaluation of screw, plate and k-wire fixation.

J Am Podiatr Med Assoc 2023 Aug 18:1-25. Epub 2023 Aug 18.

*Yozgat Bozok University, Orthopaedics and Traumatology, Yozgat, Turkey.

Background: The aim of this study was to create AO 44 A1, B1 and C1 fractures using finite element analysis (FEA), to determine the stability of k-wire, intramedullary screw (IS) and plate-screw (PS) fixation methods in fracture Methods: Using FEA the post-reduction behaviour of AO 44 A1, B1 and C1 fractures with k-wire, IS and PS fixation methods was analysed and compared in terms of displacement and stress.

Results: The lowest amount of displacement was provided with the IS method in AO 44 A1 and B1. It was observed in the detection of 4 mm k-wire in AO 44 C1. Read More

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Childhood Non-verbal Communication Scale (CNCS): Turkish Adaptation and Psychometric Properties.

Noro Psikiyatr Ars 2023 3;60(3):257-264. Epub 2023 Aug 3.

Samsun Education and Research Hospital, Department of Family Medicine, Samsun, Turkey.

Introduction: Nonverbal communication (NC) skills develop dramatically during the first year of life. Especially in children with Autism Spectrum Disorder (ASD), inadequacies in these skills in the early period negatively affect language development later. Therefore, early recognition of ASD symptoms is the first step in the diagnosis. Read More

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Case-based report of graded motor imagery experience in traumatic brachial plexus injury: The art of moving without moving.

J Hand Ther 2023 Aug 14. Epub 2023 Aug 14.

The Hand Clinic, Ankara, Turkey.

Background: We reported a 24-year-old woman who sustained multiple upper limb injuries after a traffic accident in March 2017. She sustained a C7-T1 brachial plexus injury and radial nerve injury on the left side diagnosed in November 2017. The patient underwent radial nerve reconstruction. Read More

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The prognostic value of P53 index in predicting the recurrence of early low-risk endometrial cancer.

J Obstet Gynaecol Res 2023 Jul 27. Epub 2023 Jul 27.

Department of Obstetrics and Gynecology, Muğla Sıtkı Koçman University, Muğla, Turkey.

Aim: We aimed to clarify the clinical value of P53 index in patients with early low-risk endometrial cancer (EC) and find an optimal cut-off value of P53 index for predicting the recurrence of these patients.

Methods: The clinicopathological data of 157 patients with early low-risk EC (stage 1A with grade 1 or 2 endometrioid EC) were analyzed. The optimal cut-off value of the P53 index was calculated by the receiver operating characteristic curve analysis and Youden index. Read More

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Characteristics and predictors of family accommodation in Turkish individuals with obsessive-compulsive disorder.

Turk J Med Sci 2023 Apr 19;53(2):594-602. Epub 2023 Apr 19.

Alanya Alaaddin Keykubat University Training and Research Hospital, Department of Psychiatry, Antalya, Turkey.

Background: Family accommodation (FA) is associated with disease severity and response to treatment rates in patients with obsessive-compulsive disorder (OCD) and is therefore particularly important in this patient group. This study investigated the structure of FA and associated factors in a Turkish society sample.

Methods: The study was carried out with 92 patients diagnosed with OCD for at least 1 year, who applied to Alanya ALKU Training and Research Hospital psychiatry outpatient clinic between February 2021 and March 2022. Read More

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Metal-Chelated Polymeric Nanomaterials for the Removal of Penicillin G Contamination.

Polymers (Basel) 2023 Jun 27;15(13). Epub 2023 Jun 27.

Department of Biochemistry, Faculty of Science, Ege University, 35100 Izmir, Turkey.

We developed selective and relatively low-cost metal-chelated nanoparticle systems for the removal of the penicillin G (Pen G) antibiotic, presented for the first time in the literature. In the nanosystem, poly(glycidyl methacrylate) nanoparticles were synthesized by a surfactant-free emulsion polymerization method and covalently bound with a tridentate-chelating ligand, iminodiacetic acid, based on the immobilized metal chelate affinity technique. It was modified with Cu, a chelating metal, to make Pen G specific. Read More

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Assessment of Reliability of Three Indices Measuring Gingival Overgrowth.

Acta Stomatol Croat 2023 Jun;57(2):98-112

Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul,

Objectives: Numerous indices have been used to grade the severity of gingival overgrowth which led to suspicion regarding the results concerning its prevalence and pathogenicity. The aim of this study was to assess the concordance of three different gingival overgrowth indices, which were used widely in previous studies, and check their reliability and reproducibility.

Material And Methods: A total of 30 full-mouth plaster casts and 90 intra-oral photographs collected from 30 patients diagnosed with gingival overgrowth were included in our study. Read More

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Short-term clinical and hormonal effects of a deslorelin implant on late-prepubertal bitches - Based on flare-up signs.

Theriogenology 2023 Oct 25;209:162-169. Epub 2023 Jun 25.

Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Türkiye. Electronic address:

Gonadotropin-releasing hormone (GnRH) agonists offer an alternative to surgical sterilization in prepubertal dogs, preserving ovarian and uterine functions. However, the clinical and hormonal effects of GnRH agonist application during the late-prepubertal stage remain insufficiently understood. This study aimed to investigate the clinical effect (flare-up) and hormonal changes, specifically serum progesterone (P4) and estradiol (E2) levels, in bitches treated with 4. Read More

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October 2023

An investigation of bovine papillomaviruses from ocular squamous cell carcinomas in cattle.

Iran J Vet Res 2023 ;24(1):51-57

Ph.D. Student in Pathology, Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey.

Background: Ocular squamous cell carcinomas (OSCCs) in cattle has been studied for many years, but no definite etiology has been established. Squamous cell carcinomas (SCCs) may occur in different body parts of cattle. Depending on the location, it can cause an economic loss of varying degrees. Read More

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January 2023

Fostering mask-wearing with virality metrics and social media literacy: evidence from the U.S. and Korea.

Front Psychol 2023 24;14:1151061. Epub 2023 May 24.

School of Media and Communication, Korea University, Seoul, Republic of Korea.

Although social media can pose threats to the public health by spreading misinformation and causing confusion, they can also provide wider access to health information and opportunities for health surveillance. The current study investigates the ways in which preventive health behaviors and norms can be promoted on social media by analyzing data from surveys and experiments conducted in the U.S. Read More

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Prevention and treatment of peri-implant diseases-The EFP S3 level clinical practice guideline.

J Clin Periodontol 2023 Jun 4;50 Suppl 26:4-76. Epub 2023 Jun 4.

ETEP (Etiology and Therapy of Periodontal and Peri-implant Diseases) Research Group, University Complutense of Madrid, Madrid, Spain.

Background: The recently published Clinical Practice Guidelines (CPGs) for the treatment of stages I-IV periodontitis provided evidence-based recommendations for treating periodontitis patients, defined according to the 2018 classification. Peri-implant diseases were also re-defined in the 2018 classification. It is well established that both peri-implant mucositis and peri-implantitis are highly prevalent. Read More

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Barriers in quest for cancer care access in two states of northeast India.

Int J Health Plann Manage 2023 Sep 4;38(5):1396-1408. Epub 2023 Jun 4.

Department of Head and Neck Surgery, Deputy Director, Centre for Cancer Epidemiology, Tata Memorial Cancer Hospital, Mumbai, Maharashtra, India.

Background: The cancer burden in northeast India is high, with low survival and low case detection. Despite the availability of cancer institutes in the region, existing literature remarks on the increasing travel outside the region for cancer care. However, research is sparse on identifying impediment factors to the access of state cancer institutes. Read More

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September 2023

The Relationship of Plasma Aterogenity Index and Mean Platelet Volume with the Risk of Development of 1-Year Total Major Adverse Cardiac Event in Patients with Non-ST Elevation Myocardial Infarction.

Int J Angiol 2023 Jun 1;32(2):81-87. Epub 2023 Mar 1.

Department of Cardiology, Faculty of Medicine, Ankara University, Ankara, Turkey.

In our study, we aimed to reveal the role of plasma atherogenicity index and mean platelet volume in predicting the risk of developing a 1-year major adverse cardiac event (MACE) in patients with non-ST elevation myocardial infarction (NSTEMI). This study, which was planned from the retrospective cross-sectional study model, was performed with 100 patients diagnosed with NSTEMI and scheduled for coronary angiography. The laboratory values of the patients were evaluated, the atherogenicity index of plasma was calculated, and the 1-year MACE status was evaluated. Read More

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Osteocalcin and cross-linked C-terminal telopeptide of type I collagen in gingival crevicular fluid during piezocision accelerated orthodontic tooth movement: A randomized split-mouth study.

Niger J Clin Pract 2023 Apr;26(4):470-477

Department of Periodontology, Dental Faculty, Marmara University, Istanbul, Turkey.

Background: Piezocision, a minimally invasive surgical procedure, has been used to accelerate tooth movement'' is appropriate as a background to the abstract section.

Aim: The aim of this randomized split-mouth study was to evaluate gingival crevicular fluid (GCF) osteocalcin (OC) and type I collagen cross-linked C-terminal telopeptide (ICTP) levels during canine distalization with and without piezocision acceleration.

Material And Methods: Fifteen systemically healthy subjects (M:F 7:8, 16. Read More

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A novel subtype of sporadic Creutzfeldt-Jakob disease with PRNP codon 129MM genotype and PrP plaques.

Acta Neuropathol 2023 Jul 8;146(1):121-143. Epub 2023 May 8.

Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

The presence of amyloid kuru plaques is a pathological hallmark of sporadic Creutzfeldt-Jakob disease (sCJD) of the MV2K subtype. Recently, PrP plaques (p) have been described in the white matter of a small group of CJD (p-CJD) cases with the 129MM genotype and carrying resPrP type 1 (T1). Despite the different histopathological phenotype, the gel mobility and molecular features of p-CJD resPrP T1 mimic those of sCJDMM1, the most common human prion disease. Read More

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The manifold role of octapeptide repeats in prion protein assembly.

Pept Sci (Hoboken) 2023 Mar 30;115(2). Epub 2023 Jan 30.

Department of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.

Prion protein misfolding is associated with fatal neurodegenerative disorders such as kuru, Creutzfeldt-Jakob disease, and several animal encephalopathies. While the C-terminal 106-126 peptide has been well studied for its role in prion replication and toxicity, the octapeptide repeat (OPR) sequence found within the N-terminal domain has been relatively under explored. Recent findings that the OPR has both local and long-range effects on prion protein folding and assembly, as well as its ability to bind and regulate transition metal homeostasis, highlights the important role this understudied region may have in prion pathologies. Read More

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Comparison of Particulate, Block and Putty Forms of β-tricalcium Phosphate-Based Synthetic Bone Grafts on Rat Calvarium Model.

J Maxillofac Oral Surg 2023 Jun 27;22(2):296-303. Epub 2022 May 27.

Department of Biomedical Engineering, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Izmir, Turkey.

Purpose: Bone augmentation is a necessity for atrophied alveolar ridge prior to dental implant placement. Various bone graft types and forms with different characteristics are available in the market for alveolar augmentation. Beta tricalcium phosphate (β-TCP) is a synthetic biomaterial known as the oldest type of calcium phosphate. Read More

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Antioxidant Supplementation on Male Fertility-A Systematic Review.

Antioxidants (Basel) 2023 Mar 30;12(4). Epub 2023 Mar 30.

Department of Urology, Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, 14476 Potsdam, Germany.

Unlabelled: Our aim was to review the current literature regarding the effect of antioxidant supplementation (AS) on male fertility parameters, as AS is commonly used to treat male infertility due to the availability and affordability of antioxidants in many parts of the world.

Materials And Methods: PubMed, Medline, and Cochrane electronic bibliographies were searched using the modified Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines to evaluate studies on the benefit of antioxidant therapy on infertile men. Results were analyzed regarding the following aspects: (a) ingredient and dose; (b) potential mechanism of action and rationale for use; and (c) effect on various reported outcomes. Read More

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Occlusion of dentinal tubules on periodontally involved teeth by dentifrice containing stannous fluoride and sodium fluoride.

J Oral Sci 2023 Jul 27;65(3):149-152. Epub 2023 Apr 27.

Department of Periodontology, Faculty of Dentistry, Marmara University.

Purpose: This study examined the occlusion effect of a dentifrice containing stannous fluoride (SnF) and sodium fluoride (NaF) on periodontally involved teeth in comparison with healthy teeth using scanning electron microscopy (SEM) in comparison with a dentifrice containing NaF alone.

Methods: Sixty dentine samples obtained from single-rooted premolars, 15 of them extracted for orthodontic reasons (Group H) and 15 because of periodontal destruction (Group P), were included in the study. Each group of specimens was further divided into subgroups: HC and PC (control), H1 and P1 (treated with SnF and NaF), and H2 and P2 (treated with NaF). Read More

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