1,564 results match your criteria Kuru


Human prion diseases.

Curr Opin Infect Dis 2019 Jun;32(3):272-276

Department of Neurology, University Hospitals Cleveland Medical Center.

Purpose Of Review: Prion diseases are rapidly progressive neurodegenerative conditions that can be difficult to diagnose and are transmissible under specific circumstances. The authors will provide background regarding prion disease and focus on diagnostic tools.

Recent Findings: Prion disease is caused by misfolded prion protein. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000552DOI Listing

Prognostic factors and oncological outcomes of ovarian yolk sac tumors: a retrospective multicentric analysis of 99 cases.

Arch Gynecol Obstet 2019 Apr 13. Epub 2019 Apr 13.

Division of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Etlik, 06010, Ankara, Turkey.

Purpose: To investigate the clinico-pathological prognostic factors and treatment outcomes in patients with ovarian yolk sac tumors (YST).

Methods: A multicenter, retrospective department database review was performed to identify patients with ovarian YST who underwent surgery between 2000 and 2017 at seven Gynecologic Oncology Centers in Turkey.

Results: The study group consisted of 99 consecutive patients with a mean age of 23. Read More

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http://link.springer.com/10.1007/s00404-019-05160-6
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http://dx.doi.org/10.1007/s00404-019-05160-6DOI Listing
April 2019
2 Reads

Anatomical and histological analysis of the salpinx and ovary in Anatolian Wild Goat (Capra aegagrus aegagrus).

Folia Morphol (Warsz) 2019 Mar 19. Epub 2019 Mar 19.

Department of Histology and Embriyology, Faculty of Veterinary Medicine, Kafkas University, Turkey.

Background: This study determined the anatomical structure of the salpinx and ovary of the Anatolian wild goat (C. aegagrus aegagrus).

Materials And Methods: The salpinges and ovaries from four wild goats of similar ages were used. Read More

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http://dx.doi.org/10.5603/FM.a2019.0032DOI Listing

Kuru, the First Human Prion Disease.

Viruses 2019 Mar 7;11(3). Epub 2019 Mar 7.

Department of Anthropology, Graduate Center, City University of New York, New York, NY 10016, USA.

Kuru, the first human prion disease was transmitted to chimpanzees by D. Carleton Gajdusek (1923⁻2008). In this review, we summarize the history of this seminal discovery, its anthropological background, epidemiology, clinical picture, neuropathology, and molecular genetics. Read More

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http://dx.doi.org/10.3390/v11030232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466359PMC
March 2019
8 Reads

Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration.

BMJ Case Rep 2019 Mar 7;12(3). Epub 2019 Mar 7.

Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.

Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disease that can mimic other neurological disorders. We present a case of sCJD in a 64-year-old man that presented with corticobasal syndrome and survived for 3 years. He presented initially with dementia, hemiparkinsonism and alien limb phenomenon and was diagnosed with corticobasal degeneration, ultimately progressing to immobility and akinetic mutism. Read More

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http://dx.doi.org/10.1136/bcr-2018-228305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424260PMC

[Fusion biopsies for primary diagnosis of prostate cancer : Implementation, benefits, and clinical aspects].

Urologe A 2019 Mar 5. Epub 2019 Mar 5.

Klinik für Urologie, Universitätsklinikum Köln, Köln, Deutschland.

Prostate carcinoma is one of the most common tumors worldwide. Histological confirmation by biopsy is an obligatory part of the diagnostic approach. The main problem of the 10-12-fold transrectal ultrasound-guided (TRUS) biopsy, which has so far been regarded as the gold standard, is the underdiagnosis of clinically significant cancer. Read More

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http://dx.doi.org/10.1007/s00120-019-0889-2DOI Listing
March 2019
6 Reads

Reliability and Validity of Turkish Version of Short Form of the Social Role Participation Questionnaire in Patients With Ankylosing Spondylitis.

Arch Rheumatol 2018 Dec 11;33(4):408-417. Epub 2018 Apr 11.

Department of Physical Therapy and Rehabilitation, Medicine Faculty of Ondokuz Mayıs University, Samsun, Turkey.

Objectives: This study aims to evaluate the reliability and validity of the Turkish version of the Short Form of the Social Role Participation Questionnaire (s-SRPQ) in Turkish patients with ankylosing spondylitis.

Patients And Methods: The Turkish version of s-SRPQ questionnaire was obtained after a translation and back translation process. The study sample included 100 ankylosing spondylitis patients (59 males, 41 females; mean age 42. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2018.6756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386251PMC
December 2018
1 Read

Fluorogenic D-amino acids enable real-time monitoring of peptidoglycan biosynthesis and high-throughput transpeptidation assays.

Nat Chem 2019 04 25;11(4):335-341. Epub 2019 Feb 25.

Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, USA.

Peptidoglycan is an essential cell wall component that maintains the morphology and viability of nearly all bacteria. Its biosynthesis requires periplasmic transpeptidation reactions, which construct peptide crosslinkages between polysaccharide chains to endow mechanical strength. However, tracking the transpeptidation reaction in vivo and in vitro is challenging, mainly due to the lack of efficient, biocompatible probes. Read More

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http://dx.doi.org/10.1038/s41557-019-0217-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444347PMC
April 2019
2 Reads

Turkish League Against Rheumatism (TLAR) Recommendations for the Pharmacological Management of Rheumatoid Arthritis: 2018 Update Under Guidance of Current Recommendations.

Arch Rheumatol 2018 Sep 9;33(3):251-271. Epub 2018 Jul 9.

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Objectives: This study aims to report the assessment of the Turkish League Against Rheumatism (TLAR) expert panel on the compliance and adaptation of the European League Against Rheumatism (EULAR) 2016 recommendations for the management of rheumatoid arthritis (RA) in Turkey.

Patients And Methods: The EULAR 2016 recommendations for the treatment of RA were voted by 27 specialists experienced in this field with regard to participation rate for each recommendation and significance of items. Afterwards, each recommendation was brought forward for discussion and any alteration gaining ≥70% approval was accepted. Read More

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https://www.archivesofrheumatology.org/full-text/979
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http://dx.doi.org/10.5606/ArchRheumatol.2018.6911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328226PMC
September 2018
15 Reads

Feasibility study of intelligent autonomous determination of the bladder voiding need to treat bedwetting using ultrasound and smartphone ML techniques : Intelligent autonomous treatment of bedwetting.

Med Biol Eng Comput 2019 May 26;57(5):1079-1097. Epub 2018 Dec 26.

University of Central Lancashire, Preston, UK.

Unsatisfactory cure rates for the treatment of nocturnal enuresis (NE), i.e. bed-wetting, have led to the need to explore alternative modalities. Read More

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http://link.springer.com/10.1007/s11517-018-1942-9
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http://dx.doi.org/10.1007/s11517-018-1942-9DOI Listing
May 2019
9 Reads

Evaluation and comparison of the film thicknesses of six temporary cements before and after thermal cycling.

Niger J Clin Pract 2018 Dec;21(12):1656-1661

Bitlis Oral and Dental Health Hospital, Bitlis, Turkey.

Aim: Temporary cement can be applied for both permanent and temporary cementation of implant-supported fixed restorations. These cements must have certain physical and mechanical properties. Specifically, the film thickness directly affects the cement's clinical success. Read More

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http://dx.doi.org/10.4103/njcp.njcp_382_17DOI Listing
December 2018

Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.

PLoS Pathog 2018 11 29;14(11):e1007424. Epub 2018 Nov 29.

Institute of Neuropathology, University Hospital Zürich, Zürich University, Zürich, Switzerland.

Transmissible spongiform encephalopathies (TSEs) are caused by the prion, which consists essentially of PrPSc, an aggregated, conformationally modified form of the cellular prion protein (PrPC). Although TSEs can be experimentally transmitted by intracerebral inoculation, most instances of infection in the field occur through extracerebral routes. The epidemics of kuru and variant Creutzfeldt-Jakob disease were caused by dietary exposure to prions, and parenteral administration of prion-contaminated hormones has caused hundreds of iatrogenic TSEs. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264140PMC
November 2018
3 Reads

Bone Flap Technique With Piezosurgery for Impacted Teeth Extraction and Bone Cysts Removal Without Additional Fixation.

J Craniofac Surg 2019 Jan;30(1):e21-e24

Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Izmir Katip Celebi University, Izmir, Turkey.

To explore a new surgical approach for impacted teeth extraction and cystectomy using piezosurgery that provides proper bone healing in normal anatomical structure without additional fixation and graft materials.In cases with intact and relatively thicker vestibular compact bone, a bone flap design was used with converging osteotomy lines made with piezosurgery tips which allow proper stabilization after enucleation or extraction.Procedure was performed in 10 patients with 9 to 36 months follow-up resulted in satisfactory healing without any complications. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004913DOI Listing
January 2019
2 Reads

Compomers Reinforced with Bioactive Glass and Hydroxyapatite Particles.

Oral Health Prev Dent 2018 ;16(5):431-438

Purpose: To understand the effect of the addition of hydroxyapatite (HA) and bioactive glass (BAG) to compomer restorative materials on the remineralisation capacity of the material.

Materials And Methods: 1%, 2%, 3% and 4% w/w HA and BAG particles were added mechanically to the compomers. To examine the resistance to demineralisation, Class V cavities were prepared in extracted teeth and restored with experimental filling materials. Read More

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http://dx.doi.org/10.3290/j.ohpd.a41405DOI Listing
January 2018
19 Reads

Association of work instability with fatigue and emotional status in patients with ankylosing spondylitis: comparison with healthy controls.

Clin Rheumatol 2019 Apr 17;38(4):1017-1024. Epub 2018 Nov 17.

Department of Physical Medicine and Rehabilitation, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey.

Introduction/objective: Ankylosing spondylitis (AS) is usually seen in among younger person of working age and carries a significant economic burden. It was aimed to explore the relation of work instability with fatigue, depression, and anxiety in working AS patients comparing with healthy controls.

Method: This case-control study was conducted on working 61 AS patients and 40 sex-age-matched working healthy controls. Read More

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http://link.springer.com/10.1007/s10067-018-4366-x
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http://dx.doi.org/10.1007/s10067-018-4366-xDOI Listing
April 2019
16 Reads

Effects of global postural reeducation exercise and anti-TNF treatments on disease activity, function, fatigue, mobility, sleep quality and depression in patients with active Ankylosing spondylitis: A prospective follow-up study.

J Back Musculoskelet Rehabil 2018 ;31(6):1005-1012

Objective: The purpose of this study was to investigate the effects of combination therapy with global postural reeducation exercise (GPR) and anti-TNF treatments on clinical parameters in patients with active Ankylosing spondylitis (AS).

Materials And Method: Sixty patients with active AS were distributed into three groups. Group 1 was given anti-TNF therapy plus GPR program. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/BMR-170901DOI Listing
January 2019
24 Reads

Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis.

World Neurosurg 2019 Feb 3;122:e989-e994. Epub 2018 Nov 3.

Department of Neurosurgery, Fatih Sultan Mehmet Education and Research Hospital, University of Health Sciences, Turkish Ministry of Health, Istanbul, Turkey.

Background: Epidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. We used a rat laminectomy model to determine if topical application of boric acid could be helpful in the prevention of epidural fibrosis.

Methods: Rats were randomly assigned to 2 control and 2 experimental groups (n = 8 for each group). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183249
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http://dx.doi.org/10.1016/j.wneu.2018.10.187DOI Listing
February 2019
15 Reads

Specific amyloid-β42 deposition in the brain of a Gerstmann-Sträussler-Scheinker disease patient with a P105L mutation on the prion protein gene.

Prion 2018 13;12(5-6):315-319. Epub 2018 Nov 13.

a Department of Neurology and Neurological Science , Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences , Yushima Bunkyo-ku , Tokyo , Japan.

Although colocalization of amyloid β (Aβ) with prion protein (PrP) in the kuru plaque has previously been observed in the brain of prion diseases patients, the participating Aβ species has not been identified. Here, we present an immunohistochemical assessment of the brain and spinal cord of a 69-year-old Japanese female patient with Gerstmann-Sträussler-Scheinker disease with a P105L mutation on the PRNP gene (GSS-P105L). Immunohistochemical assessment of serial brain sections was performed using anti-PrP and -Aβ antibodies in the hippocampus, frontal and occipital lobes. Read More

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https://www.tandfonline.com/doi/full/10.1080/19336896.2018.1
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http://dx.doi.org/10.1080/19336896.2018.1541689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277180PMC
November 2018
5 Reads

Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease.

J Neurol Neurosurg Psychiatry 2019 Apr 24;90(4):424-427. Epub 2018 Oct 24.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

Objective: To assess whether the involvement of the peripheral nervous system (PNS) belongs to the phenotypic spectrum of sporadic Creutzfeldt-Jakob disease (sCJD).

Methods: We examined medical records of 117 sCJDVV2 (ataxic type), 65 sCJDMV2K (kuru-plaque type) and 121 sCJDMM(V)1 (myoclonic type) subjects for clinical symptoms, objective signs and neurophysiological data. We reviewed two diagnostic nerve biopsies and looked for abnormal prion protein (PrP) by western blotting and real-time quaking-induced conversion (RT-QuIC) in postmortem PNS samples from 14 subjects. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319221DOI Listing
April 2019
4 Reads

Cellular and Molecular Mechanisms of Prion Disease.

Annu Rev Pathol 2019 Jan 24;14:497-516. Epub 2018 Oct 24.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Prion diseases are rapidly progressive, incurable neurodegenerative disorders caused by misfolded, aggregated proteins known as prions, which are uniquely infectious. Remarkably, these infectious proteins have been responsible for widespread disease epidemics, including kuru in humans, bovine spongiform encephalopathy in cattle, and chronic wasting disease in cervids, the latter of which has spread across North America and recently appeared in Norway and Finland. The hallmark histopathological features include widespread spongiform encephalopathy, neuronal loss, gliosis, and deposits of variably sized aggregated prion protein, ranging from small, soluble oligomers to long, thin, unbranched fibrils, depending on the disease. Read More

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http://dx.doi.org/10.1146/annurev-pathmechdis-012418-013109DOI Listing
January 2019
1 Read

Effect of chicken feather and boron compounds as filler on mechanical and flame retardancy properties of polymer composite materials.

Waste Manag Res 2018 Nov 15;36(11):1029-1036. Epub 2018 Oct 15.

2 Chemical Engineering Department, Gazi University, Gazi, Turkey.

Sustainable utilisation of solid waste has been influenced by the increasing population of the world. Benefits of using solid waste based on natural fibre in polymer material are biodegradability and cost effectiveness. In poultry farms, chicken poultry, one of the slaughterhouse wastes is confronted with 30 10 kg of waste per year in Turkey. Read More

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http://journals.sagepub.com/doi/10.1177/0734242X18804041
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http://dx.doi.org/10.1177/0734242X18804041DOI Listing
November 2018
1 Read

Central liponeurocytoma as a clinical entity.

Neurol Neurochir Pol 2018 Nov - Dec;52(6):670-676. Epub 2018 Sep 11.

Turkish Ministry of Health, University of Health Sciences, Fatih Sultan Mehmet Education and Research Hospital, Department of Neurosurgery, Istanbul, Turkey.

Introduction: Liponeurocytomas are mostly localized in cerebellar hemispheres and the second most common location is the vermis. It is rarely observed within the intracranial ventricles. Here, we present a case of liponeurocytoma located in the right lateral ventricle and the systematic review of the literature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283843183008
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http://dx.doi.org/10.1016/j.pjnns.2018.09.001DOI Listing
September 2018
11 Reads

[Dimensional Approach to Obsessive-Compulsive Disorder: Dimensional Obsessive-Compulsive Scale with Turkish Psychometric Properties].

Turk Psikiyatri Derg 2018 ;29(2):122-130

Objective: The Dimensional Obsessive Compulsive Scale (DOCS) is a measurement tool that examines the severity of thematically distinct symptom domains of obsessive compulsive disorder (OCD). In this study we assess psychometric properties of the Turkish version of DOCS.

Methods: Ninety-six patients who presented consecutively to the Dışkapı Yıldırım Beyazıt Teaching and Research Hospital outpatient unit and who were diagnosed with OCD according to the DSM-IV-TR criteria were enrolled in the study. Read More

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November 2018
3 Reads

Characteristic findings of skeletal muscle MRI in caveolinopathies.

Neuromuscul Disord 2018 Oct 31;28(10):857-862. Epub 2018 Jul 31.

Department of Pediatrics, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan. Electronic address:

Caveolinopathies, caused by CAV3 mutations, can include several phenotypes such as rippling muscle disease, limb-girdle muscular dystrophy type 1C, distal myopathy, familial hypertrophic cardiomyopathy, and idiopathic hyperCKemia. Here we present characteristic skeletal muscle imaging findings in four patients with genetically defined childhood-onset RMD caused by CAV3 mutations and in one patient with congenital generalized lipodystrophy type 4 with muscular dystrophy due to polymerase I and transcript release factor (PTRF) mutations, which may have caused secondary deficiency of caveolin-3. Muscle MRI revealed that the rectus femoris and semitendinosus muscles were most commonly affected in the rippling muscle disease patients. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.07.010DOI Listing
October 2018
11 Reads
2.640 Impact Factor

Perceived social support and quality of life of parents of children with Autism.

Authors:
N Kuru B Piyal

Niger J Clin Pract 2018 Sep;21(9):1182-1189

Department of Public Health, Faculty of Medicine, Ankara University, Ankara, Turkey.

Background: When examining the incidence of autism, however, children should not be considered independent of their parents, as this collection of disorders also affects the life of their family members. Having a disabled child affects the relationships with the family and friends, and the social and work life of families. The quality of life of these families is discussed in terms of financial aspects, health, support of family members, values, occupation, family relations, and individual support dimensions of developmental disabilities. Read More

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http://dx.doi.org/10.4103/njcp.njcp_13_18DOI Listing
September 2018
1 Read

Oral health status and its relation with medication and dental fear in children with attention-deficit hyperactivity disorder.

Niger J Clin Pract 2018 Sep;21(9):1132-1138

Department of Microbiology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.

Objective: The objective of this study was to determine the ora-dental health and its relation with medication and dental fear in a group of Turkish children with attention-deficit hyperactivity disorder (ADHD).

Subjects And Methods: The levels of dental fear of children were determined with The Dental Subscale of Children's Fear Survey Schedule (CFSS-DS). The oral and dental health evaluation was performed. Read More

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http://dx.doi.org/10.4103/njcp.njcp_409_17DOI Listing
September 2018
9 Reads

Modeling the impact of drug interactions on therapeutic selectivity.

Nat Commun 2018 08 27;9(1):3452. Epub 2018 Aug 27.

Faculty of Engineering and Natural Sciences, Sabanci University, 34956, Istanbul, Turkey.

Combination therapies that produce synergistic growth inhibition are widely sought after for the pharmacotherapy of many pathological conditions. Therapeutic selectivity, however, depends on the difference between potency on disease-causing cells and potency on non-target cell types that cause toxic side effects. Here, we examine a model system of antimicrobial compound combinations applied to two highly diverged yeast species. Read More

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http://dx.doi.org/10.1038/s41467-018-05954-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110842PMC
August 2018
22 Reads

Contribution of Heme Oxygenase 2 to Blood Pressure Regulation in Response to Swimming Exercise and Detraining in Spontaneously Hypertensive Rats.

Med Sci Monit 2018 Aug 22;24:5851-5859. Epub 2018 Aug 22.

Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

BACKGROUND We aimed to determine the effects of exercise followed by detraining on systolic blood pressure (SBP), heme oxygenase 2 (HO-2) expression, and carboxyhemoglobin (COHb) concentration in spontaneously hypertensive rats (SHR) to explain the role of carbon monoxide (CO) in this process. MATERIAL AND METHODS Animals were randomized into exercised and detrained groups. Corresponding sedentary rats were grouped as Time 1-2. Read More

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http://dx.doi.org/10.12659/MSM.908992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116639PMC
August 2018
4 Reads

Rectal application of argan oil improves healing of colorectal anastomosis in rats1.

Acta Cir Bras 2018 Jul;33(7):565-576

Full Professor, Ankara Education and Research Hospital, Department of Pathology, Ankara, Turkey. Histopathological examinations.

Purpose: To investigate the possible effects of argan oil on the healing of colorectal anastomoses.

Methods: n Group 1 (sham), laparotomy was performed and the colon was mobilized. In the control (Group 2) and argan oil (Group 3) groups, colonic resection and anastomosis were applied. Read More

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http://dx.doi.org/10.1590/s0102-865020180070000002DOI Listing
July 2018
34 Reads
0.570 Impact Factor

Efficacy of adjunctive photodynamic therapy in the treatment of generalized aggressive periodontitis: A randomized controlled clinical trial.

Lasers Surg Med 2019 Feb 10;51(2):167-175. Epub 2018 Aug 10.

Faculty of Dentistry, Department of Periodontology, Marmara University, Istanbul, Turkey.

Objectives: Generalized aggressive periodontitis (GAgP) is a distinct type of periodontal disease characterized by rapid loss of attachment and alveolar bone occurring in young individuals. Photodynamic therapy (PDT) was introduced in periodontology as an adjunctive approach to non-surgical periodontal treatment (NPT) in periodontitis patients. In this trial, the aim was to evaluate the clinical and microbiological effects of adjunctive PDT to NPT in patients with GAgP. Read More

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http://dx.doi.org/10.1002/lsm.23010DOI Listing
February 2019
15 Reads
2.620 Impact Factor

Autopsied case of non-plaque-type dura mater graft-associated Creutzfeldt-Jakob disease presenting with extensive amyloid-β deposition.

Neuropathology 2018 Oct 6;38(5):549-556. Epub 2018 Aug 6.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

We present an autopsied case of non-plaque-type dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) with extensive amyloid-β (Aβ) deposition in the brain. A 39-year-old Japanese woman presented with memory disturbance and abnormal behavior. The patient had a history of craniotomy with dura matter-graft transplant for a head injury which occurred when she was 19 years old. Read More

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http://dx.doi.org/10.1111/neup.12503DOI Listing
October 2018
1 Read

Confinement of Dirac electrons in graphene magnetic quantum dots.

J Phys Condens Matter 2018 Sep 27;30(36):365502. Epub 2018 Jul 27.

Department of Physics, Faculty of Science, Ankara University, 06100 Ankara, Turkey.

We characterize the confinement of massless Dirac electrons under axially symmetric magnetic fields in graphene, including zero energy modes and higher energy levels. In particular, we analyze in detail the Aharonov-Casher theorem, on the existence of zero modes produced by magnetic fields with finite flux in two dimensions. We apply techniques of supersymmetric quantum mechanics to determine the confined states by means of the quantum number j associated to isospin and angular momentum. Read More

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http://dx.doi.org/10.1088/1361-648X/aad656DOI Listing
September 2018
1 Read

Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects.

Biomed Res Int 2018 28;2018:3874131. Epub 2018 Jun 28.

Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey.

Hyaluronic acid (HA) constitutes one of the major components of the extracellular matrix domain in almost all mammals. The aim of this study was to evaluate the regenerative capacity of HA matrix in rat calvarial bone defects and compare with those of different combinations of resorbable collagen membrane (M) and bovine-derived xenograft (G). Twenty-four 3-month-old male Sprague-Dawley rats weighing 200-250 g were included. Read More

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http://dx.doi.org/10.1155/2018/3874131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046155PMC
January 2019
5 Reads

[Human prion diseases: current issues].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(6):88-95

Institute of Medical and Social Technologies, Moscow State University of Food Production, Moscow, Russia.

Prion diseases, or transmissible spongiform encephalopathies, are a group of neurodegenerative diseases with progressive dementia and movement disorders. There are three variants of prion diseases pathogenesis: direct contamination, genetic and sporadic forms. The following clinical forms are known: Creutzfeldt-Jakob disease (common type), variant Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker disease, variably protease-sensitive prionopathy, fatal insomnia and fatal familial insomnia, kuru, prion disease associated with diarrhea and autonomic neuropathy. Read More

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http://dx.doi.org/10.17116/jnevro20181186188DOI Listing
January 2018
17 Reads

Meckel's diverticulum: clinical features, diagnosis and management.

Rev Esp Enferm Dig 2018 Nov;110(11):726-732

General Surgery Department, Ankara Education and Research Hospital, Turkey.

Meckel's diverticulum is the most common anomalous development of the gastrointestinal system that results from an incomplete vitelline canal. A diagnosis is usually made during the clinical examination of presentations such as unexplained gastrointestinal bleeding, obstruction, inflammation or perforation. The purpose of this review is to provide an adequate level of knowledge of the clinical and diagnostic features as well as the management of Meckel's diverticulum. Read More

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http://dx.doi.org/10.17235/reed.2018.5628/2018DOI Listing
November 2018
10 Reads

Twelve-month prostate volume reduction after MRI-guided transurethral ultrasound ablation of the prostate.

Eur Radiol 2019 Jan 25;29(1):299-308. Epub 2018 Jun 25.

Department of Radiology (E010), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Purpose: To quantitatively assess 12-month prostate volume (PV) reduction based on T2-weighted MRI and immediate post-treatment contrast-enhanced MRI non-perfused volume (NPV), and to compare measurements with predictions of acute and delayed ablation volumes based on MR-thermometry (MR-t), in a central radiology review of the Phase I clinical trial of MRI-guided transurethral ultrasound ablation (TULSA) in patients with localized prostate cancer.

Materials And Methods: Treatment day MRI and 12-month follow-up MRI and biopsy were available for central radiology review in 29 of 30 patients from the published institutional review board-approved, prospective, multi-centre, single-arm Phase I clinical trial of TULSA. Viable PV at 12 months was measured as the remaining PV on T2-weighted MRI, less 12-month NPV, scaled by the fraction of fibrosis in 12-month biopsy cores. Read More

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http://dx.doi.org/10.1007/s00330-018-5584-yDOI Listing
January 2019
7 Reads

Bicytopenia Associated with Paroxetine: a Case Report.

Psychiatr Danub 2018 Jun;30(2):227-229

Department of Psychiatry, Boylam Psychiatric Hospital, Ankara, Turkey,

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http://dx.doi.org/10.24869/psyd.2018.227DOI Listing

Turkish League Against Rheumatism Consensus Report: Recommendations For Management of Axial Spondyloarthritis.

Arch Rheumatol 2018 Mar 14;33(1):1-16. Epub 2018 Feb 14.

Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ankara University School of Medicine, Ankara, Turkey.

Objectives: This study aims to update 2011 Turkish League Against Rheumatism SpondyloArthritis Recommendations, and to compose a national expert opinion on management of axial spondyloArthritis under guidance of current guidelines, and implantation and dissemination of these international guidelines into our clinical practice.

Patients And Methods: A scientific committee of 28 experts consisting of 14 rheumatologists and 14 physical medicine and rehabilitation specialists (one of them also has an immunology PhD) was formed. The recommendations, systematic reviews, and meta-analyses including pharmacologic and non-pharmacologic treatment were scrutinized paying special attention with convenient key words. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2018.6833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864166PMC
March 2018
46 Reads

Human transmissible spongiform encephalopathies: historic view.

Handb Clin Neurol 2018 ;153:1-17

Laboratory of Bacterial and Transmissible Spongiform Encephalopathy Agents, Division of Emerging and Transfusion-Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

The first of several pivotal moments leading to current understanding of human transmissible spongiform encephalopathies (TSEs) occurred in 1959 when veterinary pathologist W.J. Hadlow first recognized several similarities between scrapie-a slow infection of sheep caused by an unusual infectious agent-and kuru, a fatal exotic neurodegenerative disease affecting only people of a single language group in the remote mountainous interior of New Guinea, described two years earlier by D. Read More

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http://dx.doi.org/10.1016/B978-0-444-63945-5.00001-5DOI Listing
September 2018
7 Reads

Frequency of Rearrangements Versus Small Indels Mutations in and Genes in Turkish Patients with High Risk Breast and Ovarian Cancer.

Eur J Breast Health 2018 Apr 1;14(2):93-99. Epub 2018 Apr 1.

Department of Medical Oncology, Oncology Institute, University of Istanbul, İstanbul, Turkey.

Objective: The current rearrangement ratio of and genes is not known in the Turkish population. Rearrangements are not routinely investigated in many Turkish laboratories. This creates problems and contradictions between clinics. Read More

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http://www.eurjbreasthealth.com/eng/makale/609/54/Full-Text
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http://dx.doi.org/10.5152/ejbh.2017.3799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939985PMC
April 2018
16 Reads

Echoes from the 40 Annual San Antonio Breast Cancer Symposium, 2017.

Authors:
Bekir Kuru

Eur J Breast Health 2018 Apr 1;14(2):72-73. Epub 2018 Apr 1.

Department of General Surgery, Ondokuz Mayis University School of Medicine, Samsun, Turkey.

The Annual San Antonio Symposium was held on 5-9, December, 2017 in San Antonio, Texas, USA (1). As expected, many new studies were presented for the first time at the sessions. The unofficial opening lecture in my point of view was given on locoregional recurrence by Monica Morrow from MSKCC, New York. Read More

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http://www.eurjbreasthealth.com/eng/makale/602/54/Full-Text
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http://dx.doi.org/10.5152/ejbh.2018.3948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939981PMC
April 2018
18 Reads

The Renin-Angiotensin System, Not the Kinin-Kallikrein System, Affects Post-Exercise Proteinuria.

Nephron 2018 17;139(4):299-304. Epub 2018 May 17.

Department of Physiology, Akdeniz University, Medical Faculty, Antalya, Turkey.

Background/aims: Temporary proteinuria post-exercise is common and is caused predominantly by renal haemodynamic alterations. One reason is up-regulation of angiotensin II (Ang II) due to the reducing effect of angiotensin-converting enzyme (ACE) inhibitors. However, another, ignored, reason could be the kininase effect of ACE inhibition. Read More

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http://dx.doi.org/10.1159/000489506DOI Listing
May 2018
2 Reads

Genomic features of renal cell carcinoma with venous tumor thrombus.

Sci Rep 2018 May 10;8(1):7477. Epub 2018 May 10.

Section of Molecular Urooncology, Department of Urology, University of Heidelberg School of Medicine, Im Neuenheimer Feld 517, D-69120, Heidelberg, Germany.

A venous tumor thrombus (VTT) is a potentially lethal complication of renal cell carcinoma (RCC) but virtually nothing is known about the underlying natural history. Based on our observation that venous thrombi contain significant numbers of viable tumor cells, we applied multiregion whole exome sequencing to a total of 37 primary tumor and VTT samples including normal tissue specimens from five consecutive patients. Our findings demonstrate mutational heterogeneity between primary tumor and VTT with 106 of 483 genes (22%) harboring functional SNVs and/or indels altered in either primary tumor or thrombus. Read More

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http://dx.doi.org/10.1038/s41598-018-25544-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945671PMC
May 2018
18 Reads

Correction to: Impaired coronary blood flow may be related to elevated homocysteine levels in patients with metabolic syndrome.

Wien Klin Wochenschr 2018 06;130(11-12):408

Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey.

Correction to: Wien Klin Wochenschr 2015 https://doi.org/10.1007/s00508-015-0854-z The original version of this article unfortunately contained a mistake. Read More

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http://dx.doi.org/10.1007/s00508-018-1342-zDOI Listing
June 2018
17 Reads

Montelukast attenuates radioactive I131-induced pulmonary damage on rats.

Int J Radiat Biol 2018 06 27;94(6):542-550. Epub 2018 Apr 27.

b Department of Nuclear Medicine , University of Health Sciences, Ankara Training and Research Hospital , Ankara , Turkey.

Purpose: Radioactive I131 (RAI) therapy is a standard method to ablate the remnant thyroidal tissue after total thyroidectomy and its metastases in differentiated thyroid carcinomas; however, I131 also accumulates in nonthyroidal tissue, which may cause adverse effects and limit the I131 dose required for treatment. We hypothesized that montelukast, a known agent with anti-inflammatory and anti-oxidant properties, would ameliorate the radiation-induced histopathological characteristics such as pneumonitis and fibrosis in rat lungs after RAI.

Methods: Fifty female Wistar albino rats were randomly separated into five groups of 10. Read More

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http://dx.doi.org/10.1080/09553002.2018.1466065DOI Listing
June 2018
12 Reads

Boron Content of Some Foods Consumed in Istanbul, Turkey.

Biol Trace Elem Res 2019 Jan 14;187(1):1-8. Epub 2018 Apr 14.

Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.

The boron content was determined in 42 different foods consumed in Istanbul, Turkey. Eleven species of fruit, ten species of vegetable, eight species of food of animal origin, four species of grain, two species of nuts, two species of legume, and five other kinds of foods were included to this study. They were analyzed by two methods: Inductively coupled plasma mass spectrometry (ICP-MS) technique and carminic acid assay, and the results of two methods were also compared. Read More

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http://dx.doi.org/10.1007/s12011-018-1319-9DOI Listing
January 2019
6 Reads
1.748 Impact Factor

Host-Polarized Cell Growth in Animal Symbionts.

Curr Biol 2018 Apr 22;28(7):1039-1051.e5. Epub 2018 Mar 22.

University of Vienna, Department of Ecogenomics and Systems Biology, Archaeal Biology and Ecogenomics Division, Althanstrasse 14, 1090 Vienna, Austria. Electronic address:

To determine the fundamentals of cell growth, we must extend cell biological studies to non-model organisms. Here, we investigated the growth modes of the only two rods known to widen instead of elongating, Candidatus Thiosymbion oneisti and Thiosymbion hypermnestrae. These bacteria are attached by one pole to the surface of their respective nematode hosts. Read More

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http://dx.doi.org/10.1016/j.cub.2018.02.028DOI Listing
April 2018
27 Reads

Risk factors associated with malignancy and with triage to surgery in thyroid nodules classified as Bethesda category IV (FN/SFN).

Diagn Cytopathol 2018 Jun 10;46(6):489-494. Epub 2018 Mar 10.

Department of Pathology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.

Background: Thyroid nodules diagnosed as Bethesda category IV [follicular neoplasm/suspicious for follicular neoplasm (FN/SFN)] are recommended for surgery. However, only 10%-40% of these nodules turn out to be malignant on histopathological examination. Therefore, selection for surgery of nodules diagnosed as Bethesda category IV is important. Read More

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http://dx.doi.org/10.1002/dc.23923DOI Listing
June 2018
7 Reads

A Neuroleptic Malignant Syndrome Without Rigidity.

Psychiatry Investig 2018 Feb 14;15(2):226-229. Epub 2017 Dec 14.

Uşak State Hospital, Psychiatry Clinic, Uşak, Turkey.

Neuroleptic malignant syndrome (NMS) is an uncommon but potentially lethal idiosyncratic reaction which may emerge in the aftermath of the treatments with neuroleptics demonstrating itself with the symptoms of altered consciousness, high fever, impaired autonomic functions, and muscle rigidity. Although various risk factors have been identified for NMS, its etiology is not completely known. The mortality and morbidity related with NMS could be reduced by early diagnosis, interruption of the neuroleptics used within a short period and aggressive treatment. Read More

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http://dx.doi.org/10.30773/pi.2017.06.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900391PMC
February 2018
5 Reads

The relationship between theory of mind and insight in obsessive-compulsive disorder.

Nord J Psychiatry 2018 May 9;72(4):273-280. Epub 2018 Feb 9.

f Department of Psychiatry , Tavşanlı State Hospital , Tavşanlı, Kütahya , Turkey.

Background: It is known that obsessive-compulsive disorder (OCD) patients with poor insight display more severe neuropsychological impairments than other patients with OCD. There are limited studies of OCD and theory of mind (ToM).

Aim: To investigate ToM skills in patients with OCD and the relationship between insight and ToM skills by comparing OCD patients with good and poor insight. Read More

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http://dx.doi.org/10.1080/08039488.2018.1436724DOI Listing
May 2018
10 Reads