1,553 results match your criteria Kuru


Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.

PLoS Pathog 2018 Nov 29;14(11):e1007424. Epub 2018 Nov 29.

Institute of Neuropathology, University Hospital Zürich, Zürich University, Zürich, Switzerland.

Transmissible spongiform encephalopathies (TSEs) are caused by the prion, which consists essentially of PrPSc, an aggregated, conformationally modified form of the cellular prion protein (PrPC). Although TSEs can be experimentally transmitted by intracerebral inoculation, most instances of infection in the field occur through extracerebral routes. The epidemics of kuru and variant Creutzfeldt-Jakob disease were caused by dietary exposure to prions, and parenteral administration of prion-contaminated hormones has caused hundreds of iatrogenic TSEs. Read More

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November 2018
1 Read

Bone Flap Technique With Piezosurgery for Impacted Teeth Extraction and Bone Cysts Removal Without Additional Fixation.

J Craniofac Surg 2018 Nov 22. Epub 2018 Nov 22.

Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Izmir Katip Celebi University, Izmir, Turkey.

To explore a new surgical approach for impacted teeth extraction and cystectomy using piezosurgery that provides proper bone healing in normal anatomical structure without additional fixation and graft materials.In cases with intact and relatively thicker vestibular compact bone, a bone flap design was used with converging osteotomy lines made with piezosurgery tips which allow proper stabilization after enucleation or extraction.Procedure was performed in 10 patients with 9 to 36 months follow-up resulted in satisfactory healing without any complications. Read More

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November 2018
1 Read

Compomers Reinforced with Bioactive Glass and Hydroxyapatite Particles.

Oral Health Prev Dent 2018 ;16(5):431-438

Purpose: To understand the effect of the addition of hydroxyapatite (HA) and bioactive glass (BAG) to compomer restorative materials on the remineralisation capacity of the material.

Materials And Methods: 1%, 2%, 3% and 4% w/w HA and BAG particles were added mechanically to the compomers. To examine the resistance to demineralisation, Class V cavities were prepared in extracted teeth and restored with experimental filling materials. Read More

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January 2018
2 Reads

Association of work instability with fatigue and emotional status in patients with ankylosing spondylitis: comparison with healthy controls.

Clin Rheumatol 2018 Nov 17. Epub 2018 Nov 17.

Department of Physical Medicine and Rehabilitation, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey.

Introduction/objective: Ankylosing spondylitis (AS) is usually seen in among younger person of working age and carries a significant economic burden. It was aimed to explore the relation of work instability with fatigue, depression, and anxiety in working AS patients comparing with healthy controls.

Method: This case-control study was conducted on working 61 AS patients and 40 sex-age-matched working healthy controls. Read More

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November 2018
8 Reads

Effects of global postural reeducation exercise and anti-TNF treatments on disease activity, function, fatigue, mobility, sleep quality and depression in patients with active Ankylosing spondylitis: A prospective follow-up study.

J Back Musculoskelet Rehabil 2018 ;31(6):1005-1012

Objective: The purpose of this study was to investigate the effects of combination therapy with global postural reeducation exercise (GPR) and anti-TNF treatments on clinical parameters in patients with active Ankylosing spondylitis (AS).

Materials And Method: Sixty patients with active AS were distributed into three groups. Group 1 was given anti-TNF therapy plus GPR program. Read More

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January 2018
6 Reads

Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis.

World Neurosurg 2018 Nov 3. Epub 2018 Nov 3.

Department of Neurosurgery, Fatih Sultan Mehmet Education and Research Hospital, University of Health Sciences, Turkish Ministry of Health, Istanbul, Turkey.

Background: Epidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. We used a rat laminectomy model to determine if topical application of boric acid could be helpful in the prevention of epidural fibrosis.

Methods: Rats were randomly assigned to 2 control and 2 experimental groups (n = 8 for each group). Read More

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November 2018
4 Reads

Specific amyloid-β42 deposition in the brain of a Gerstmann-Sträussler-Scheinker disease patient with a P105L mutation on the prion protein gene.

Prion 2018 13;12(5-6):315-319. Epub 2018 Nov 13.

a Department of Neurology and Neurological Science , Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences , Yushima Bunkyo-ku , Tokyo , Japan.

Although colocalization of amyloid β (Aβ) with prion protein (PrP) in the kuru plaque has previously been observed in the brain of prion diseases patients, the participating Aβ species has not been identified. Here, we present an immunohistochemical assessment of the brain and spinal cord of a 69-year-old Japanese female patient with Gerstmann-Sträussler-Scheinker disease with a P105L mutation on the PRNP gene (GSS-P105L). Immunohistochemical assessment of serial brain sections was performed using anti-PrP and -Aβ antibodies in the hippocampus, frontal and occipital lobes. Read More

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November 2018
5 Reads

Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease.

J Neurol Neurosurg Psychiatry 2018 Oct 24. Epub 2018 Oct 24.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

Objective: To assess whether the involvement of the peripheral nervous system (PNS) belongs to the phenotypic spectrum of sporadic Creutzfeldt-Jakob disease (sCJD).

Methods: We examined medical records of 117 sCJDVV2 (ataxic type), 65 sCJDMV2K (kuru-plaque type) and 121 sCJDMM(V)1 (myoclonic type) subjects for clinical symptoms, objective signs and neurophysiological data. We reviewed two diagnostic nerve biopsies and looked for abnormal prion protein (PrP) by western blotting and real-time quaking-induced conversion (RT-QuIC) in postmortem PNS samples from 14 subjects. Read More

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October 2018
1 Read

Cellular and Molecular Mechanisms of Prion Disease.

Annu Rev Pathol 2018 Oct 24. Epub 2018 Oct 24.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Prion diseases are rapidly progressive, incurable neurodegenerative disorders caused by misfolded, aggregated proteins known as prions, which are uniquely infectious. Remarkably, these infectious proteins have been responsible for widespread disease epidemics, including kuru in humans, bovine spongiform encephalopathy in cattle, and chronic wasting disease in cervids, the latter of which has spread across North America and recently appeared in Norway and Finland. The hallmark histopathological features include widespread spongiform encephalopathy, neuronal loss, gliosis, and deposits of variably sized aggregated prion protein, ranging from small, soluble oligomers to long, thin, unbranched fibrils, depending on the disease. Read More

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October 2018

Effect of chicken feather and boron compounds as filler on mechanical and flame retardancy properties of polymer composite materials.

Waste Manag Res 2018 Nov 15;36(11):1029-1036. Epub 2018 Oct 15.

2 Chemical Engineering Department, Gazi University, Gazi, Turkey.

Sustainable utilisation of solid waste has been influenced by the increasing population of the world. Benefits of using solid waste based on natural fibre in polymer material are biodegradability and cost effectiveness. In poultry farms, chicken poultry, one of the slaughterhouse wastes is confronted with 30 10 kg of waste per year in Turkey. Read More

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November 2018
1 Read

Central liponeurocytoma as a clinical entity.

Neurol Neurochir Pol 2018 Sep 11. Epub 2018 Sep 11.

Turkish Ministry of Health, University of Health Sciences, Fatih Sultan Mehmet Education and Research Hospital, Department of Neurosurgery, Istanbul, Turkey.

Introduction: Liponeurocytomas are mostly localized in cerebellar hemispheres and the second most common location is the vermis. It is rarely observed within the intracranial ventricles. Here, we present a case of liponeurocytoma located in the right lateral ventricle and the systematic review of the literature. Read More

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September 2018
11 Reads

[Dimensional Approach to Obsessive-Compulsive Disorder: Dimensional Obsessive-Compulsive Scale with Turkish Psychometric Properties].

Turk Psikiyatri Derg 2018 ;29(2):122-130

Objective: The Dimensional Obsessive Compulsive Scale (DOCS) is a measurement tool that examines the severity of thematically distinct symptom domains of obsessive compulsive disorder (OCD). In this study we assess psychometric properties of the Turkish version of DOCS.

Methods: Ninety-six patients who presented consecutively to the Dışkapı Yıldırım Beyazıt Teaching and Research Hospital outpatient unit and who were diagnosed with OCD according to the DSM-IV-TR criteria were enrolled in the study. Read More

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November 2018
1 Read

Characteristic findings of skeletal muscle MRI in caveolinopathies.

Neuromuscul Disord 2018 Oct 31;28(10):857-862. Epub 2018 Jul 31.

Department of Pediatrics, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan. Electronic address:

Caveolinopathies, caused by CAV3 mutations, can include several phenotypes such as rippling muscle disease, limb-girdle muscular dystrophy type 1C, distal myopathy, familial hypertrophic cardiomyopathy, and idiopathic hyperCKemia. Here we present characteristic skeletal muscle imaging findings in four patients with genetically defined childhood-onset RMD caused by CAV3 mutations and in one patient with congenital generalized lipodystrophy type 4 with muscular dystrophy due to polymerase I and transcript release factor (PTRF) mutations, which may have caused secondary deficiency of caveolin-3. Muscle MRI revealed that the rectus femoris and semitendinosus muscles were most commonly affected in the rippling muscle disease patients. Read More

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October 2018
3 Reads
2.640 Impact Factor

Perceived social support and quality of life of parents of children with Autism.

Authors:
N Kuru B Piyal

Niger J Clin Pract 2018 Sep;21(9):1182-1189

Department of Public Health, Faculty of Medicine, Ankara University, Ankara, Turkey.

Background: When examining the incidence of autism, however, children should not be considered independent of their parents, as this collection of disorders also affects the life of their family members. Having a disabled child affects the relationships with the family and friends, and the social and work life of families. The quality of life of these families is discussed in terms of financial aspects, health, support of family members, values, occupation, family relations, and individual support dimensions of developmental disabilities. Read More

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September 2018
1 Read

Oral health status and its relation with medication and dental fear in children with attention-deficit hyperactivity disorder.

Niger J Clin Pract 2018 Sep;21(9):1132-1138

Department of Microbiology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.

Objective: The objective of this study was to determine the ora-dental health and its relation with medication and dental fear in a group of Turkish children with attention-deficit hyperactivity disorder (ADHD).

Subjects And Methods: The levels of dental fear of children were determined with The Dental Subscale of Children's Fear Survey Schedule (CFSS-DS). The oral and dental health evaluation was performed. Read More

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September 2018
6 Reads

Modeling the impact of drug interactions on therapeutic selectivity.

Nat Commun 2018 08 27;9(1):3452. Epub 2018 Aug 27.

Faculty of Engineering and Natural Sciences, Sabanci University, 34956, Istanbul, Turkey.

Combination therapies that produce synergistic growth inhibition are widely sought after for the pharmacotherapy of many pathological conditions. Therapeutic selectivity, however, depends on the difference between potency on disease-causing cells and potency on non-target cell types that cause toxic side effects. Here, we examine a model system of antimicrobial compound combinations applied to two highly diverged yeast species. Read More

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August 2018
9 Reads

Contribution of Heme Oxygenase 2 to Blood Pressure Regulation in Response to Swimming Exercise and Detraining in Spontaneously Hypertensive Rats.

Med Sci Monit 2018 Aug 22;24:5851-5859. Epub 2018 Aug 22.

Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

BACKGROUND We aimed to determine the effects of exercise followed by detraining on systolic blood pressure (SBP), heme oxygenase 2 (HO-2) expression, and carboxyhemoglobin (COHb) concentration in spontaneously hypertensive rats (SHR) to explain the role of carbon monoxide (CO) in this process. MATERIAL AND METHODS Animals were randomized into exercised and detrained groups. Corresponding sedentary rats were grouped as Time 1-2. Read More

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August 2018
3 Reads

Rectal application of argan oil improves healing of colorectal anastomosis in rats1.

Acta Cir Bras 2018 Jul;33(7):565-576

Full Professor, Ankara Education and Research Hospital, Department of Pathology, Ankara, Turkey. Histopathological examinations.

Purpose: To investigate the possible effects of argan oil on the healing of colorectal anastomoses.

Methods: n Group 1 (sham), laparotomy was performed and the colon was mobilized. In the control (Group 2) and argan oil (Group 3) groups, colonic resection and anastomosis were applied. Read More

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July 2018
18 Reads
0.570 Impact Factor

Efficacy of adjunctive photodynamic therapy in the treatment of generalized aggressive periodontitis: A randomized controlled clinical trial.

Lasers Surg Med 2018 Aug 10. Epub 2018 Aug 10.

Faculty of Dentistry, Department of Periodontology, Marmara University, Istanbul, Turkey.

Objectives: Generalized aggressive periodontitis (GAgP) is a distinct type of periodontal disease characterized by rapid loss of attachment and alveolar bone occurring in young individuals. Photodynamic therapy (PDT) was introduced in periodontology as an adjunctive approach to non-surgical periodontal treatment (NPT) in periodontitis patients. In this trial, the aim was to evaluate the clinical and microbiological effects of adjunctive PDT to NPT in patients with GAgP. Read More

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August 2018
11 Reads
2.620 Impact Factor

Autopsied case of non-plaque-type dura mater graft-associated Creutzfeldt-Jakob disease presenting with extensive amyloid-β deposition.

Neuropathology 2018 Oct 6;38(5):549-556. Epub 2018 Aug 6.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

We present an autopsied case of non-plaque-type dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) with extensive amyloid-β (Aβ) deposition in the brain. A 39-year-old Japanese woman presented with memory disturbance and abnormal behavior. The patient had a history of craniotomy with dura matter-graft transplant for a head injury which occurred when she was 19 years old. Read More

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October 2018

Confinement of Dirac electrons in graphene magnetic quantum dots.

J Phys Condens Matter 2018 Sep 27;30(36):365502. Epub 2018 Jul 27.

Department of Physics, Faculty of Science, Ankara University, 06100 Ankara, Turkey.

We characterize the confinement of massless Dirac electrons under axially symmetric magnetic fields in graphene, including zero energy modes and higher energy levels. In particular, we analyze in detail the Aharonov-Casher theorem, on the existence of zero modes produced by magnetic fields with finite flux in two dimensions. We apply techniques of supersymmetric quantum mechanics to determine the confined states by means of the quantum number j associated to isospin and angular momentum. Read More

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September 2018
1 Read

Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects.

Biomed Res Int 2018 28;2018:3874131. Epub 2018 Jun 28.

Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey.

Hyaluronic acid (HA) constitutes one of the major components of the extracellular matrix domain in almost all mammals. The aim of this study was to evaluate the regenerative capacity of HA matrix in rat calvarial bone defects and compare with those of different combinations of resorbable collagen membrane (M) and bovine-derived xenograft (G). Twenty-four 3-month-old male Sprague-Dawley rats weighing 200-250 g were included. Read More

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June 2018
3 Reads

[Human prion diseases: current issues].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(6):88-95

Institute of Medical and Social Technologies, Moscow State University of Food Production, Moscow, Russia.

Prion diseases, or transmissible spongiform encephalopathies, are a group of neurodegenerative diseases with progressive dementia and movement disorders. There are three variants of prion diseases pathogenesis: direct contamination, genetic and sporadic forms. The following clinical forms are known: Creutzfeldt-Jakob disease (common type), variant Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker disease, variably protease-sensitive prionopathy, fatal insomnia and fatal familial insomnia, kuru, prion disease associated with diarrhea and autonomic neuropathy. Read More

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January 2018
7 Reads

Meckel's diverticulum: clinical features, diagnosis and management.

Rev Esp Enferm Dig 2018 Nov;110(11):726-732

General Surgery Department, Ankara Education and Research Hospital, Turkey.

Meckel's diverticulum is the most common anomalous development of the gastrointestinal system that results from an incomplete vitelline canal. A diagnosis is usually made during the clinical examination of presentations such as unexplained gastrointestinal bleeding, obstruction, inflammation or perforation. The purpose of this review is to provide an adequate level of knowledge of the clinical and diagnostic features as well as the management of Meckel's diverticulum. Read More

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November 2018
7 Reads

Twelve-month prostate volume reduction after MRI-guided transurethral ultrasound ablation of the prostate.

Eur Radiol 2019 Jan 25;29(1):299-308. Epub 2018 Jun 25.

Department of Radiology (E010), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Purpose: To quantitatively assess 12-month prostate volume (PV) reduction based on T2-weighted MRI and immediate post-treatment contrast-enhanced MRI non-perfused volume (NPV), and to compare measurements with predictions of acute and delayed ablation volumes based on MR-thermometry (MR-t), in a central radiology review of the Phase I clinical trial of MRI-guided transurethral ultrasound ablation (TULSA) in patients with localized prostate cancer.

Materials And Methods: Treatment day MRI and 12-month follow-up MRI and biopsy were available for central radiology review in 29 of 30 patients from the published institutional review board-approved, prospective, multi-centre, single-arm Phase I clinical trial of TULSA. Viable PV at 12 months was measured as the remaining PV on T2-weighted MRI, less 12-month NPV, scaled by the fraction of fibrosis in 12-month biopsy cores. Read More

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January 2019
6 Reads

Bicytopenia Associated with Paroxetine: a Case Report.

Psychiatr Danub 2018 Jun;30(2):227-229

Department of Psychiatry, Boylam Psychiatric Hospital, Ankara, Turkey,

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Turkish League Against Rheumatism Consensus Report: Recommendations For Management of Axial Spondyloarthritis.

Arch Rheumatol 2018 Mar 14;33(1):1-16. Epub 2018 Feb 14.

Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ankara University School of Medicine, Ankara, Turkey.

Objectives: This study aims to update 2011 Turkish League Against Rheumatism SpondyloArthritis Recommendations, and to compose a national expert opinion on management of axial spondyloArthritis under guidance of current guidelines, and implantation and dissemination of these international guidelines into our clinical practice.

Patients And Methods: A scientific committee of 28 experts consisting of 14 rheumatologists and 14 physical medicine and rehabilitation specialists (one of them also has an immunology PhD) was formed. The recommendations, systematic reviews, and meta-analyses including pharmacologic and non-pharmacologic treatment were scrutinized paying special attention with convenient key words. Read More

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March 2018
29 Reads

Human transmissible spongiform encephalopathies: historic view.

Handb Clin Neurol 2018 ;153:1-17

Laboratory of Bacterial and Transmissible Spongiform Encephalopathy Agents, Division of Emerging and Transfusion-Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

The first of several pivotal moments leading to current understanding of human transmissible spongiform encephalopathies (TSEs) occurred in 1959 when veterinary pathologist W.J. Hadlow first recognized several similarities between scrapie-a slow infection of sheep caused by an unusual infectious agent-and kuru, a fatal exotic neurodegenerative disease affecting only people of a single language group in the remote mountainous interior of New Guinea, described two years earlier by D. Read More

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September 2018
6 Reads

Frequency of Rearrangements Versus Small Indels Mutations in and Genes in Turkish Patients with High Risk Breast and Ovarian Cancer.

Eur J Breast Health 2018 Apr 1;14(2):93-99. Epub 2018 Apr 1.

Department of Medical Oncology, Oncology Institute, University of Istanbul, İstanbul, Turkey.

Objective: The current rearrangement ratio of and genes is not known in the Turkish population. Rearrangements are not routinely investigated in many Turkish laboratories. This creates problems and contradictions between clinics. Read More

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April 2018
8 Reads

Echoes from the 40 Annual San Antonio Breast Cancer Symposium, 2017.

Authors:
Bekir Kuru

Eur J Breast Health 2018 Apr 1;14(2):72-73. Epub 2018 Apr 1.

Department of General Surgery, Ondokuz Mayis University School of Medicine, Samsun, Turkey.

The Annual San Antonio Symposium was held on 5-9, December, 2017 in San Antonio, Texas, USA (1). As expected, many new studies were presented for the first time at the sessions. The unofficial opening lecture in my point of view was given on locoregional recurrence by Monica Morrow from MSKCC, New York. Read More

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April 2018
1 Read

The Renin-Angiotensin System, Not the Kinin-Kallikrein System, Affects Post-Exercise Proteinuria.

Nephron 2018 17;139(4):299-304. Epub 2018 May 17.

Department of Physiology, Akdeniz University, Medical Faculty, Antalya, Turkey.

Background/aims: Temporary proteinuria post-exercise is common and is caused predominantly by renal haemodynamic alterations. One reason is up-regulation of angiotensin II (Ang II) due to the reducing effect of angiotensin-converting enzyme (ACE) inhibitors. However, another, ignored, reason could be the kininase effect of ACE inhibition. Read More

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May 2018
1 Read

Genomic features of renal cell carcinoma with venous tumor thrombus.

Sci Rep 2018 May 10;8(1):7477. Epub 2018 May 10.

Section of Molecular Urooncology, Department of Urology, University of Heidelberg School of Medicine, Im Neuenheimer Feld 517, D-69120, Heidelberg, Germany.

A venous tumor thrombus (VTT) is a potentially lethal complication of renal cell carcinoma (RCC) but virtually nothing is known about the underlying natural history. Based on our observation that venous thrombi contain significant numbers of viable tumor cells, we applied multiregion whole exome sequencing to a total of 37 primary tumor and VTT samples including normal tissue specimens from five consecutive patients. Our findings demonstrate mutational heterogeneity between primary tumor and VTT with 106 of 483 genes (22%) harboring functional SNVs and/or indels altered in either primary tumor or thrombus. Read More

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May 2018
14 Reads

Correction to: Impaired coronary blood flow may be related to elevated homocysteine levels in patients with metabolic syndrome.

Wien Klin Wochenschr 2018 May 7. Epub 2018 May 7.

Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey.

Correction to: Wien Klin Wochenschr 2015 https://doi.org/10.1007/s00508-015-0854-z The original version of this article unfortunately contained a mistake. Read More

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May 2018
13 Reads

Montelukast attenuates radioactive I131-induced pulmonary damage on rats.

Int J Radiat Biol 2018 Jun 27;94(6):542-550. Epub 2018 Apr 27.

b Department of Nuclear Medicine , University of Health Sciences, Ankara Training and Research Hospital , Ankara , Turkey.

Purpose: Radioactive I131 (RAI) therapy is a standard method to ablate the remnant thyroidal tissue after total thyroidectomy and its metastases in differentiated thyroid carcinomas; however, I131 also accumulates in nonthyroidal tissue, which may cause adverse effects and limit the I131 dose required for treatment. We hypothesized that montelukast, a known agent with anti-inflammatory and anti-oxidant properties, would ameliorate the radiation-induced histopathological characteristics such as pneumonitis and fibrosis in rat lungs after RAI.

Methods: Fifty female Wistar albino rats were randomly separated into five groups of 10. Read More

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June 2018
7 Reads

Boron Content of Some Foods Consumed in Istanbul, Turkey.

Biol Trace Elem Res 2018 Apr 14. Epub 2018 Apr 14.

Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.

The boron content was determined in 42 different foods consumed in Istanbul, Turkey. Eleven species of fruit, ten species of vegetable, eight species of food of animal origin, four species of grain, two species of nuts, two species of legume, and five other kinds of foods were included to this study. They were analyzed by two methods: Inductively coupled plasma mass spectrometry (ICP-MS) technique and carminic acid assay, and the results of two methods were also compared. Read More

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April 2018
2 Reads
1.748 Impact Factor

Host-Polarized Cell Growth in Animal Symbionts.

Curr Biol 2018 Apr 22;28(7):1039-1051.e5. Epub 2018 Mar 22.

University of Vienna, Department of Ecogenomics and Systems Biology, Archaeal Biology and Ecogenomics Division, Althanstrasse 14, 1090 Vienna, Austria. Electronic address:

To determine the fundamentals of cell growth, we must extend cell biological studies to non-model organisms. Here, we investigated the growth modes of the only two rods known to widen instead of elongating, Candidatus Thiosymbion oneisti and Thiosymbion hypermnestrae. These bacteria are attached by one pole to the surface of their respective nematode hosts. Read More

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April 2018
16 Reads

Risk factors associated with malignancy and with triage to surgery in thyroid nodules classified as Bethesda category IV (FN/SFN).

Diagn Cytopathol 2018 Jun 10;46(6):489-494. Epub 2018 Mar 10.

Department of Pathology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.

Background: Thyroid nodules diagnosed as Bethesda category IV [follicular neoplasm/suspicious for follicular neoplasm (FN/SFN)] are recommended for surgery. However, only 10%-40% of these nodules turn out to be malignant on histopathological examination. Therefore, selection for surgery of nodules diagnosed as Bethesda category IV is important. Read More

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June 2018
4 Reads

A Neuroleptic Malignant Syndrome Without Rigidity.

Psychiatry Investig 2018 Feb 14;15(2):226-229. Epub 2017 Dec 14.

Uşak State Hospital, Psychiatry Clinic, Uşak, Turkey.

Neuroleptic malignant syndrome (NMS) is an uncommon but potentially lethal idiosyncratic reaction which may emerge in the aftermath of the treatments with neuroleptics demonstrating itself with the symptoms of altered consciousness, high fever, impaired autonomic functions, and muscle rigidity. Although various risk factors have been identified for NMS, its etiology is not completely known. The mortality and morbidity related with NMS could be reduced by early diagnosis, interruption of the neuroleptics used within a short period and aggressive treatment. Read More

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February 2018
3 Reads

The relationship between theory of mind and insight in obsessive-compulsive disorder.

Nord J Psychiatry 2018 May 9;72(4):273-280. Epub 2018 Feb 9.

f Department of Psychiatry , Tavşanlı State Hospital , Tavşanlı, Kütahya , Turkey.

Background: It is known that obsessive-compulsive disorder (OCD) patients with poor insight display more severe neuropsychological impairments than other patients with OCD. There are limited studies of OCD and theory of mind (ToM).

Aim: To investigate ToM skills in patients with OCD and the relationship between insight and ToM skills by comparing OCD patients with good and poor insight. Read More

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May 2018
5 Reads

Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases.

Neurosci Lett 2018 03 9;668:43-47. Epub 2018 Jan 9.

Laboratory of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan. Electronic address:

Evaluation of transmission properties is important for the differential diagnosis of a subgroup of acquired Creutzfeldt-Jakob disease (CJD) with methionine homozygosity at polymorphic codon 129 of the PRNP gene, an intermediate type abnormal prion protein (PrP), and kuru plaques, denoted as acquired CJD-MMiK. The present study aimed to develop a quick evaluation system of the transmission properties of acquired CJD-MMiK. In the PrP-humanized mice intraperitoneally inoculated with brain homogenates from an acquired CJD-MMiK patient, accumulation of abnormal PrP was observed in follicular dendritic cells of the spleen at 75 days post-inoculation. Read More

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March 2018
7 Reads

Websites on Bladder Cancer: an Appropriate Source of Patient Information?

J Cancer Educ 2018 Jan 8. Epub 2018 Jan 8.

Department of Urology, University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

A growing number of patients search for health information online. An early investigation of websites about bladder cancer (BCa) revealed mostly incomplete and particularly inaccurate information. We analyzed the quality, readability, and popularity of the most frequented websites on BCa. Read More

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January 2018
9 Reads

Author Correction: Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation.

Nat Microbiol 2018 Feb;3(2):254

Department of Biology, Indiana University Bloomington, Bloomington, IN, 47405, USA.

In the original version of this Article, a grant number and acknowledgement were omitted. The Acknowledgements section should have stated that one of the 3D SIM microscopes used for this research was supported by Medical Research Council UK grant (MR/K015753/1) to S. Foster, University of Sheffield, UK, and that the authors thank C. Read More

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February 2018
33 Reads

Engineering posttranslational proofreading to discriminate nonstandard amino acids.

Proc Natl Acad Sci U S A 2018 01 4;115(3):619-624. Epub 2018 Jan 4.

Department of Genetics, Harvard Medical School, Boston, MA 02115;

Incorporation of nonstandard amino acids (nsAAs) leads to chemical diversification of proteins, which is an important tool for the investigation and engineering of biological processes. However, the aminoacyl-tRNA synthetases crucial for this process are polyspecific in regard to nsAAs and standard amino acids. Here, we develop a quality control system called "posttranslational proofreading" to more accurately and rapidly evaluate nsAA incorporation. Read More

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January 2018
8 Reads

Morphological and Histological Study on the Foot Pads of the Anatolian Bobcat (Lynx lynx).

Anat Rec (Hoboken) 2018 05 18;301(5):932-938. Epub 2018 Jan 18.

Department of Surgical, Veterinary Faculty, Cumhuriyet University, Sivas, Turkey.

This study was conducted to reveal the morphometric and morphological features of foot pads in the Anatolian bobcat (Lynx lynx). To achieve this objective, dissection, histological, and radiography techniques were applied to two dead materials obtained from the Republic of Turkey Ministry of Forest and Water Works Sivas Branch Manager. Digit I is radiographically rudimentary in the forepaw. Read More

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May 2018
25 Reads

Description of Almafuerte, a new genus of ground spiders from South America (Araneae, Gnaphosidae).

Zootaxa 2017 Oct 24;4338(2):263-291. Epub 2017 Oct 24.

División Aracnología, Museo Argentino de Ciencias Naturales "Bernardino Rivadavia" (CONICET), Buenos Aires, Argentina..

A new genus of gnaphosid spiders, Almafuerte, gen. nov., is described for seven species from Southern South America. Read More

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October 2017
5 Reads

Antibody separation using lectin modified poly(HEMA-EDMA) hydrogel membranes.

J Biomater Sci Polym Ed 2018 03 20;29(4):344-359. Epub 2017 Dec 20.

e Department of Biochemistry, Faculty of Science , Ege University , Izmir , Turkey.

Herein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10. Read More

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March 2018
8 Reads

Outbreak of Hospital Infection from Biofilm-embedded Pan Drug-resistant , Due to a Contaminated Bronchoscope.

J Prev Med (Wilmington) 2017 27;2(2). Epub 2017 Oct 27.

Department of Molecular Microbiology, Rafik Saydam Hifzi saha, Ankara, Turkey.

Background: Colistin-resistant () has been defined as pandrug-resistant (PDR) strain. Outbreaks of PDR especially in pulmonary tract infections due to contaminated bronchoscopes have rarely been reported. The emergence of pandrug-resistant strains in both CF (Cystic Fibrosis) and non-CF clinical isolates over recent years remains of a great concern. Read More

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October 2017
11 Reads

Does the application of Ankaferd Blood Stopper rectally have positive effects on the healing of colorectal anastomosis and prevention of anastomotic leakage? An experimental study.

Biomed Pharmacother 2017 Dec 1;96:968-973. Epub 2017 Dec 1.

Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey.

The purpose of this experimental study was to evaluate the potential effects on the healing of colorectal anastomoses of the rectal administration of Ankaferd Blood Stopper (ABS). Thirty Wistar-Albino male rats were randomly separated into 3 groups. In the sham group, only laparotomy and colonic mobilization was performed. Read More

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December 2017
24 Reads
2.020 Impact Factor

Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature.

Acta Neuropathol Commun 2017 Nov 23;5(1):87. Epub 2017 Nov 23.

IRCCS Institute of Neurological Sciences, Bellaria Hospital, Via Altura 1/8, 40139, Bologna, Italy.

Amyloid plaques formed by abnormal prion protein (PrP) aggregates occur with low frequency in Creutzfeldt-Jakob disease, but represent a pathological hallmark of three relatively rare disease histotypes, namely variant CJD, sporadic CJDMV2K (methionine/valine at PRNP codon 129, PrP type 2 and kuru-type amyloid plaques) and iatrogenic CJDMMiK (MM at codon 129, PrP of intermediate type and kuru plaques). According to recent studies, however, PrP-amyloid plaques involving the subcortical and deep nuclei white matter may also rarely occur in CJDMM1 (MM at codon 129 and PrP type 1), the most common CJD histotype.To further characterize the phenotype of atypical CJDMM1 with white matter plaques (p-CJDMM1) and unravel the basis of amyloid plaque formation in such cases, we compared clinical and histopathological features and PrP physico-chemical properties between 5 p-CJDMM1 and 8 typical CJDMM1 brains lacking plaques. Read More

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November 2017
11 Reads

Erdosteine ameliorates the harmful effects of ischemia-reperfusion injury on the liver of rats.

Acta Cir Bras 2017 Oct;32(10):796-806

Associate Professor, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Conception of the study, interpretation of data.

Purpose: To investigate the potential protective effects of erdosteine against the harmful effects of ischemia-reperfusion injury on the liver in an experimental rat model.

Methods: Forty rats were divided into 4 groups. In the sham group, only the hepatic pedicle was mobilized. Read More

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October 2017
10 Reads
0.570 Impact Factor