677,347 results match your criteria Knowledge and Information Systems [Journal]


MCmatlab: an open-source, user-friendly, MATLAB-integrated three-dimensional Monte Carlo light transport solver with heat diffusion and tissue damage.

J Biomed Opt 2018 Dec;23(12):1-6

Technical University of Denmark, Department of Photonics Engineering, Roskilde, Denmark.

While there exist many Monte Carlo (MC) programs for solving the radiative transfer equation (RTE) in biological tissues, we have identified a need for an open-source MC program that is sufficiently user-friendly for use in an education environment, in which detailed knowledge of compiling or UNIX command-line cannot be assumed. Therefore, we introduce MCmatlab, an open-source codebase thus far consisting of (a) a fast three-dimensional MC RTE solver and (b) a finite-element heat diffusion and Arrhenius-based thermal tissue damage simulator, both run in MATLAB. The kernel for both of these solvers is written in parallelized C and implemented as MATLAB MEX functions, combining the speed of C with the familiarity and versatility of MATLAB. Read More

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December 2018

Nurses' perceptions about a web-based learning intervention concerning supportive family conversations in home health care.

J Clin Nurs 2018 Dec 16. Epub 2018 Dec 16.

Department of Nursing, Umeå University, Sweden.

Aims And Objectives: The aim of this study was to describe the perceptions that municipal primary health care nurses and municipal registered nurses had about a web-based learning intervention concerning supportive family health conversations in municipal home health care.

Background: Even though family health conversations is well grounded in theory with several reported benefits for patients and families, most working nurses have little or no training in practicing family systems nursing including family health conversations. Continued learning is necessarily for nurses, where web-based learning may be one answer of updating the professional skills and knowledge of nurses regarding supporting families. Read More

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December 2018

Re-examining the role of adjuvant radiation therapy.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

Surgical Oncology, Northern Clinical School, The University of Sydney, Sydney, Australia.

Previously important roles for adjuvant radiotherapy (RT) in melanoma patients included improved regional control after resection of high-risk nodal disease, to reduce local recurrence for desmoplastic, and other subtypes of melanoma with neurotropism, reducing in-brain relapse of brain metastases after surgery and other situations on a case-by-case basis. This review evaluates the integration of adjuvant RT into clinical practice at this time of rapidly evolving knowledge and improving outcomes from effective systemic therapy. Read More

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December 2018

The Challenge to Search for New Nervous System Disease Biomarker Candidates: the Opportunity to Use the Proteogenomics Approach.

J Mol Neurosci 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Functional Genomics and Bioinformatics, Oswaldo Cruz Institute, Fundação Oswaldo Cruz (Fiocruz), Manguinhos, Rio de Janeiro, Brazil.

Alzheimer's disease, Parkinson's disease, prion diseases, schizophrenia, and multiple sclerosis are the most common nervous system diseases, affecting millions of people worldwide. The current scientific literature associates these pathological conditions to abnormal expression levels of certain proteins, which in turn improved the knowledge concerning normal and affected brains. However, there is no available cure or preventive therapy for any of these disorders. Read More

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December 2018

Applying the Information-Motivation-Behavioral Skills Model to Understand PrEP Intentions and Use Among Men Who Have Sex with Men.

Authors:
Jennifer L Walsh

AIDS Behav 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychiatry and Behavioral Medicine, Center for AIDS Intervention Research, The Medical College of Wisconsin, 2071 N. Summit Avenue, Milwaukee, WI, 53202, USA.

Research is needed to determine targets for interventions to increase pre-exposure prophylaxis (PrEP) uptake. The Information-Motivation-Behavioral Skills (IMB) model has not been tested for PrEP use among men who have sex with men (MSM). Men and transgender women and men were surveyed at a community event in the Midwest in 2016 (N = 476, 60% White, M = 35). Read More

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December 2018

Genome analysis and -omics approaches provide new insights into the biodegradation potential of Rhodococcus.

Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milan, Italy.

The past few years observed a breakthrough of genome sequences of bacteria of Rhodococcus genus with significant biodegradation abilities. Invaluable knowledge from genome data and their functional analysis can be applied to develop and design strategies for attenuating damages caused by hydrocarbon contamination. With the advent of high-throughput -omic technologies, it is currently possible to utilize the functional properties of diverse catabolic genes, analyze an entire system at the level of molecule (DNA, RNA, protein, and metabolite), simultaneously predict and construct catabolic degradation pathways. Read More

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December 2018

Heterogeneous brain FDG-PET metabolic patterns in patients with C9orf72 mutation.

Neurol Sci 2018 Dec 15. Epub 2018 Dec 15.

Vita-Salute San Raffaele University, Milan, Italy.

Objective: The hexanucleotide repeat expansion in C9orf72 is an associated genetic cause in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In the "ALS/FTD" spectrum prevails clinical heterogeneity and an in vivo knowledge of the underling brain dysfunction in patients carrying C9orf72 mutation remain limited and only described at group level. The study aimed to assess the brain metabolic alterations characterizing patients with C9orf72 mutation using FDG-PET in single individuals. Read More

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December 2018

Developmental Relations Between Listening and Reading Comprehension in Young Chinese Language Learners: A Longitudinal Study.

Authors:
Yu Ka Wong

J Psycholinguist Res 2018 Dec 15. Epub 2018 Dec 15.

Department of Curriculum and Instruction, Faculty of Education, The Chinese University of Hong Kong, Shatin, Hong Kong.

The reciprocal influences between the development of Chinese-as-a-second-language (CSL) listening and reading comprehension among young learners in Hong Kong were evaluated using a 2-year, three-wave longitudinal design. A total of 129 senior primary CSL students were assessed using listening and reading comprehension tests at the end of grades 4, 5, and 6. An autoregressive, cross-lagged model was specified, and it accounted for a substantial portion of variance (more than 60%) in the two comprehension abilities by grades 5 and 6. Read More

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December 2018

Idiopathic Pulmonary Fibrosis for Cardiologists: Differential Diagnosis, Cardiovascular Comorbidities, and Patient Management.

Adv Ther 2018 Dec 15. Epub 2018 Dec 15.

U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria - Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe - MultiMedica IRCCS, Milan, Italy.

The presence of rare comorbidities in patients with cardiovascular disease (CVD) presents a diagnostic challenge to cardiologists. In evaluating these patients, cardiologists are faced with a unique opportunity to shorten diagnosis times and direct patients towards correct treatment pathways. Idiopathic pulmonary fibrosis (IPF), a type of interstitial lung disease (ILD), is an example of a rare disease where patients frequently demonstrate comorbid CVD. Read More

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December 2018

Association Between Citrus Flushing Cycles and Asian Citrus Psyllid Demography in Huanglongbing-Free Area in Brazil.

Neotrop Entomol 2018 Dec 15. Epub 2018 Dec 15.

Agricultural Defense Agency of Bahia, Salvador, BA, Brasil.

Diaphorina citri Kuwayama (Hemiptera: Liviidae), named as Asian citrus psyllid (ACP), is the vector of the bacterium associated with huanglongbing (HLB), the most destructive citrus disease. The use of citrus flushing and ACP monitoring tools is essential for the knowledge of the occurrence pattern of cycles of both and for the improvement of the ACP management. During 3 years, 20 branches from 20 trees were evaluated for vegetative flushing, ACP abundance, and occupation in tree and branches in a Brazilian citrus area free for HLB. Read More

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December 2018

Parental awareness of newborn bloodspot screening in Ireland.

Ir J Med Sci 2018 Dec 15. Epub 2018 Dec 15.

Graduate Entry Medical School and Centre for Interventions in Infection, Inflammation & Immunity (4i), University of Limerick, Limerick, Ireland.

Background: There is little known regarding how familiar parents are with the newborn bloodspot screening (NBS) test or how well parents of a child with a screen-detected condition understand that condition initially.

Aim: The study aim was to examine parental NBS awareness and conditions screened.

Methods: Two studies were conducted: [1] Parents of children with cystic fibrosis (CF) detected via NBS and subsequently, diagnosed (n = 124) completed a telephone questionnaire regarding information they received at the time of NBS. Read More

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December 2018

Perceptions of dietary factors promoting and preventing nephrolithiasis: a cross-sectional survey.

World J Urol 2018 Dec 15. Epub 2018 Dec 15.

Department of Urology, NYU Langone Hospital-Brooklyn, Brooklyn, NY, USA.

Objective: To assess knowledge of both promoting and preventive dietary factors on nephrolithiasis in a diverse patient population. Precipitating factors of kidney stone disease include diet, lifestyle, socioeconomic status, and race/ethnicity. However, patient awareness of these influences is poorly described. Read More

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December 2018

Spine deformities and trauma in Avicenna's Canon of Medicine.

Int Orthop 2018 Dec 15. Epub 2018 Dec 15.

2nd Orthopaedics Department, Medical School, University of Athens, Athens, Greece.

Aim Of The Study: The purpose of this historic review is to summarize the life and work of Avicenna (980-1037) and his contribution to the diagnosis and treatment of spinal deformities and trauma.

Method: We conducted an extensive search in libraries as well as online in Pubmed and Google Scholar.

Results: Avicenna in his work Canon of Medicine combines the knowledge of ancient Greek and Roman physicians and surgeons and he combines them with the extensive of Arabic medicine and pharmacology. Read More

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December 2018

Effectiveness of an educational intervention on seasonal influenza vaccination campaign adherence among healthcare workers of the Palermo University Hospital, Italy.

Ann Ig 2019 Jan-Feb;31(1):35-44

Department of Science for Health Promotion and Mother to Child Care "G. D'Alessandro", University of Palermo, Italy.

Introduction: Healthcare workers are continuously exposed to the risk of being infected by influenza viruses during their work, thus representing a threat especially for fragile patients. Although the Italian Ministry of Health strongly recommends influenza vaccination for all HCWs, coverage levels in Italy are still far from the expected. Several studies report that one of the preferred strategies to improve vaccination coverage among Healthcare Workers is improving vaccination knowledge through specific multidisciplinary courses. Read More

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December 2018

Use of Hepatitis C Positive Organs: Patient Attitudes in Urban Chicago.

Am J Nephrol 2018 Dec 14;49(1):32-40. Epub 2018 Dec 14.

Department of Internal Medicine, Section of Gastroenterology, Hepatology, and Nutrition, The University of Chicago Medicine, Chicago, Illinois, USA.

Background: Hepatitis C virus (HCV)-infected organs are being transplanted in patients with and without HCV in the direct-acting antiviral era. Little is known about patient attitudes towards receiving an HCV-positive organ.

Objectives: The aim of this study is to determine transplant candidates' attitudes towards receiving HCV-positive organs. Read More

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December 2018

Insufficient sleep and fitness to drive in shift workers: a systematic literature review protocol.

Inj Prev 2018 Dec 15. Epub 2018 Dec 15.

Faculty of Health Sciences, Western University, London, Ontario, Canada.

Background: The majority of shift workers experience insufficient sleep as a result of their employment. Insufficient sleep is associated with impaired neurocognitive functioning, affecting key skills required for driving, resulting in shift workers experiencing a disproportionate burden of RTC injuries and fatalities. Yet, to our knowledge, no systematic literature review (SLR) exists to critically appraise and synthesise evidence on the determinants of fitness to drive (assessed on-road) and driving performance (assessed in a driving simulator) in shift workers with insufficient sleep. Read More

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December 2018

Linkage between teen mother's childhood adversity and externalizing behaviors in their children at age 11: Three aspects of parenting.

Child Abuse Negl 2018 Dec 13;88:326-336. Epub 2018 Dec 13.

University of Southern California, Suzanne Dworak-Peck School of Social Work, Department of Children, Youth, and Families, Los Angeles, CA, 669 W. 34th Street, 90089, United States.

Background: Experiences of childhood adversity are consistently associated with compromised behavioral health later in life. Less clear is the intergenerational influence of maternal childhood adversity on developmental outcome in children. Completely unknown are the mechanisms linking teen mother's childhood adversity to child developmental outcomes. Read More

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December 2018

"It's about bloody time": Perceptions of people who use drugs regarding drug law reform.

Int J Drug Policy 2018 Dec 13;64:40-46. Epub 2018 Dec 13.

Drug Policy Modelling Program, University of New South Wales, 22-32 King Street, Randwick NSW 2031, Australia.

Background: In Australia and elsewhere, the impacts of drug prohibition have sparked a critical dialogue about the state of current drug laws. While a range of 'experts' have offered their opinion and participation in these deliberations, the voices of the affected community have largely been excluded. This study aimed to gather the opinions and preferences of people who use drugs about the current or alternative models of drug laws, in addition to how they think drug laws could be changed Author Conflict of Interest Declaration. Read More

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December 2018

Quantitatively mining and distinguishing situational discomfort grading patterns of drivers from car-following data.

Authors:
Geqi Qi Wei Guan

Accid Anal Prev 2018 Dec 13;123:282-290. Epub 2018 Dec 13.

MOE Key Laboratory of Urban, Transportation Complex System Theory and Technology, Beijing Jiaotong University, Beijing 100044, PR China. Electronic address:

Situational discomfort awareness plays an important role in decision making among drivers and has rarely been discussed in detail in previous research. An instrumented vehicle was used to collect car-following data from multiple drivers, thereby quantitatively examining situational discomfort grading patterns using a new discomfort grading method and the latent Dirichlet allocation model. In this process, the gas pedal data and speed difference data are particularly involved in the computation for providing broader meaning to discomfort and building more comprehensive situations. Read More

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December 2018

A hierarchical machine learning classification approach for secondary task identification from observed driving behavior data.

Accid Anal Prev 2018 Dec 13;123:274-281. Epub 2018 Dec 13.

Department of Civil and Environmental Engineering, University of Alabama, Huntsville, AL 35899, United States. Electronic address:

According to NHTSA, more than 3477 people (including 551 non-occupants) were killed and 391,000 were injured due to distraction-related crashes in 2015. The distracted driving epidemic has long been under research to identify its impact on driving behavior. There have been a few attempts to detect drivers' engagement in secondary tasks from observed driving behavior. Read More

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December 2018

Undergraduate nursing students' knowledge about palliative care and attitudes towards end-of-life care: A three-cohort, cross-sectional survey.

Nurse Educ Today 2018 Dec 7;74:7-14. Epub 2018 Dec 7.

National and Kapodistrian University of Athens, Athens, Greece.

Background: Ensuring adequate knowledge about palliative care and positive attitudes towards death and dying are crucial educational aspects when preparing undergraduate nursing students to respond effectively to the complexities of care for people affected by a progressive, life-limiting illness. In undergraduate nursing education in Greece, the level of students' attained knowledge and developed attitudes towards palliative and end-of-life care remain unknown.

Purpose: To investigate undergraduate nursing students' knowledge about palliative care and attitudes towards death and end-of-life care, and explore demographic and academic factors as potential moderators of student knowledge and attitudes. Read More

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December 2018

Home students' experiences of intercultural learning: A qualitative descriptive design.

Nurse Educ Today 2018 Dec 8;74:25-30. Epub 2018 Dec 8.

University of Limerick, Ireland. Electronic address:

Background: Higher education institutes are witnessing an increase in the cultural and ethnic diversity of their student population. While this adds to the learning experience, there is a dearth of evidence examining how students on nursing programmes, from different cultural and ethnic backgrounds learn with and from each other. There is need for a greater understanding of the factors that both facilitate and inhibit intercultural learning within the classroom. Read More

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December 2018

Best practices for teaching pharmacology to undergraduate nursing students: A systematic review of the literature.

Nurse Educ Today 2018 Dec 7;74:15-24. Epub 2018 Dec 7.

Faculty of Health and Social Development, School of Nursing, University of British Columbia, Kelowna, BC, Canada.

Objective: In this systematic review we describe best practices for teaching pharmacology to undergraduate baccalaureate nursing students based on the available evidence. Numerous teaching strategies employed in undergraduate pharmacology courses for nursing students have been summarized and compared for their impact on pharmacology knowledge retention, application of pharmacology theory to practice, and student satisfaction. Future directions for research are discussed. Read More

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December 2018

Testicular morphology and spermatogenesis in harbour porpoises (Phocoena phocoena).

Theriogenology 2018 Nov 28;126:177-186. Epub 2018 Nov 28.

Institute for Anatomy, University of Veterinary Medicine Hanover Foundation, Bischofsholer Damm 15, 30173, Hanover, Germany. Electronic address:

Knowledge about reproductive parameters in male harbour porpoises such as testicular histology and germ cell maturation as well as seasonal changes in spermatogenesis is scarce. Thus, the aim of the present study was to report changes in the histological appearance of the testicular morphology of neonatal and juvenile harbour porpoises during maturation, to identify stages of spermatogenesis in adult males and to detect seasonal modifications. The identification of these stages can be used to assess the developmental profile of gene expression during spermatogenesis and to identify defects in spermatogenesis arising in pathological conditions. Read More

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November 2018

A novel computational solution to the health risk assessment of air pollution via joint toxicity prediction: A case study on selected PAH binary mixtures in particulate matters.

Ecotoxicol Environ Saf 2018 Dec 13;170:427-435. Epub 2018 Dec 13.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100190, PR China; Institute of Environment and Health, Jianghan University, Wuhan 430056, PR China. Electronic address:

Regional haze episode has already caused overwhelming public concern. Unraveling the health effects of the representative composition mixtures of atmospheric fine particulate matters (PM) becomes a top priority. In this study, a novel computational solution integrating chemical-induced genomic residual effect prediction with in vitro-based risk assessment is proposed to obtain the cumulative health risk of typical chemical mixtures of particulate matters (PM). Read More

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December 2018

Iron Deficiency in Heart Failure: An Overview.

JACC Heart Fail 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology and Metabolism-Heart Failure, Cachexia and Sarcopenia, Department of Cardiology, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Iron deficiency is an extremely common co-morbidity in patients with heart failure, affecting up to 50% of all ambulatory patients. It is associated with reduced exercise capacity and physical well-being and reduced quality of life. Cutoff values have been identified for diagnosing iron deficiency in heart failure with reduced ejection fraction as serum ferritin, <100 μg/l, or ferritin, 100 to 300 μg/l, with transferrin saturation of <20%. Read More

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December 2018

Effects of high-soy diet on S100 gene expression in liver and intestine of rainbow trout (Oncorhynchus mykiss).

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Aquaculture Research Institute, University of Idaho, 3059F National Fish Hatchery Rd, Hagerman, ID, 83332, USA.

The current study examines expression of S100 genes, a group of calcium-sensing proteins poorly characterized in fishes. In mammals, these proteins are known to play roles beyond calcium-signaling, including mediation of inflammatory processes. Some S100 proteins also serve as biomarkers for a variety of autoinflammatory conditions. Read More

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December 2018

Pharmacologically evoked apnoeas. Receptors and nervous pathways involved.

Life Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Respiration Physiology, Mossakowski Medical Research Centre Polish Academy of Sciences, A. Pawińskiego 5, 02-106 Warsaw, Poland. Electronic address:

This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiration. Insight is gained into an excitatory drive of 5-HT serotonin receptors in overcoming opioid-induced respiratory inhibition. Read More

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December 2018

Full thickness intraoral mucosa barrier models for in vitro drug permeation studies employing microneedles.

J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. Electronic address:

The use of permeation enhancers such as microneedles (MNs) to increase drug penetration across intraoral mucosa has increased in recent years. Permeation studies, commonly performed using vertical diffusion cells, are a well-established way to preview formulations and enhance their performance during the development stage. However, to our knowledge, the existing intraoral mucosa barrier models do not permit permeation using MNs-pretreated mucosa, due to their insufficient thickness. Read More

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December 2018

TFAM overexpression diminishes skeletal muscle atrophy after hindlimb suspension in mice.

Arch Biochem Biophys 2018 Dec 13. Epub 2018 Dec 13.

Department of Physiology, University of Louisville, KY, USA.

The present study aims to investigate if overexpressing the mitochondrial transcription factor A (TFAM) gene in a transgenic mouse model diminishes soleus and gastrocnemius atrophy occurring during hindlimb suspension (HLS). Additionally, we aim to observe if combining exercise training in TFAM transgenic mice prior to HLS has a synergistic effect in preventing skeletal muscle atrophy. Male C57BL/6J-based transgenic mice (12-14 weeks old) overexpressing TFAM were assigned to a control (T-Control), 7-day HLS (T-HLS), and 2-week exercise training prior to 7-day HLS (T-Ex + HLS) groups. Read More

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December 2018

Diabetes mellitus and risk of pancreatic cancer in China: A meta-analysis based on 26 case-control studies.

Prim Care Diabetes 2018 Dec 12. Epub 2018 Dec 12.

Department of General Surgery, Sixth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030008, China.

Aims: The relationship between diabetes mellitus and pancreatic cancer risk from is uncertain based on the results of existing publications. The current report updated and re-evaluated the possible association between diabetes mellitus and pancreatic cancer risk in China.

Methods: Six databases (PubMed, Embase, Web of Science, the Cochrane Library, the Chinese Biomedical Database, and the Chinese National Knowledge Infrastructure) were used for the literature search up to October 2017. Read More

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December 2018

The efficacy, effectiveness, and immunogenicity of influenza vaccines in Africa: a systematic review.

Lancet Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Vaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia; Centre of International Child Health, Section of Paediatrics, Department of Medicine, Imperial College London, St Mary's Campus, London, UK. Electronic address:

The burden of influenza in Africa is substantial and underappreciated. Although surveillance has increased, the medical community's understanding of seasonal influenza vaccine performance remains limited. We did a systematic review, using PRISMA guidelines (PROSPERO CRD42017058107), on the efficacy, effectiveness, and immunogenicity of influenza vaccines in populations within Africa with the aim of identifying key data gaps to help direct future research. Read More

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December 2018

Cough and airway clearance in Duchenne muscular dystrophy.

Paediatr Respir Rev 2018 Nov 24. Epub 2018 Nov 24.

Department of Pediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy. Electronic address:

People with Duchenne muscular dystrophy (DMD), develop a respiratory muscle weakness that results in weakened cough, airway clearance impairment and over time respiratory failure and death. Assessment of cough effectiveness through vital capacity, peak cough flow and maximal inspiratory and expiratory pressures has been used to identify the optimal timing of cough augmentation techniques initiation. The choice of therapies depends on physician knowledge, and patient/care giver abilities. Read More

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November 2018
1 Read

Decisional conflict among breast cancer patients considering contralateral prophylactic mastectomy.

Patient Educ Couns 2018 Dec 10. Epub 2018 Dec 10.

Memorial Sloan Kettering Cancer Center, New York, USA.

Objectives: The study's goals were to characterize decisional conflict and preparedness for making the decision about having CPM among breast cancer patients considering CPM who do not carry cancer-predisposing mutation and to evaluate correlates of decisional conflict and preparedness.

Methods: 93 women considering CPM completed a survey of decisional conflict and preparedness for the CPM decision, knowledge, perceived risk, self-efficacy, reasons for CPM, input from others and discussion with the doctor about CPM, and cancer worry.

Results: Between 8% and 27% of women endorsed elevated decisional conflict. Read More

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December 2018

Development, adaptation and psychometric assessment of the extended brisbane practice environment measure for nursing homes (B-PEM-NH) for use in the Norwegian setting.

Geriatr Nurs 2018 Dec 12. Epub 2018 Dec 12.

Norwegian Institute of Public Health, PO Box 222 Skøyen, 0213 Oslo, Norway.

Care workers' work environment is known to be associated with patient and nurse outcomes. To our knowledge no questionnaire is available for assessing this environment for all care workers in the Norwegian nursing-home setting. This paper describes the development, adaptation and assessment of such a questionnaire: the extended Norwegian version of the Brisbane Practice Environment Measure for Nursing Homes (B-PEM-NH). Read More

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December 2018

Mutation screening of SLC52A3, C19orf12, and TARDBP in Iranian ALS patients.

Neurobiol Aging 2018 Nov 16. Epub 2018 Nov 16.

School of Biology, College of Science, University of Tehran, Tehran, Iran; Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran. Electronic address:

Mutations in the same gene are sometimes the cause of different clinically diagnosed neurologic disorders; this emphasizes interrelationships between various neurologic diseases. In this light, we screened SLC52A3, which is the cause of Brown-Vialetto-Van Laere syndrome, and C19orf12, which is the cause of neurodegeneration with brain iron accumulation in 60 Iranian amyotrophic lateral sclerosis (ALS) patients without mutations in the 2 most important ALS-causing genes, SOD1 and C9orf72. To the best of our knowledge, neither SLC52A3 nor C19orf12 has been mutation-screened previously in ALS cohorts. Read More

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November 2018

A model to evaluate data science in nursing doctoral curricula.

Nurs Outlook 2018 Nov 2. Epub 2018 Nov 2.

The University of Arizona, College of Nursing, Tucson, AZ. Electronic address:

Background: Building on the efforts of the American Association of Colleges of Nursing, we developed a model to infuse data science constructs into doctor of philosophy (PhD) curriculum. Using this model, developing nurse scientists can learn data science and be at the forefront of data driven healthcare.

Purpose: Here we present the Data Science Curriculum Organizing Model (DSCOM) to guide comprehensive doctoral education about data science. Read More

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November 2018

Exposure to sublethal doses of insecticide and their effects on insects at cellular and physiological levels.

Curr Opin Insect Sci 2018 Dec 27;30:73-78. Epub 2018 Sep 27.

Laboratoire « Signalisation Fonctionnelle des Canaux Ioniques et Récepteurs » (SiFCIR), UPRES-EA2647 USC INRA 1330, SFR 4207 QUASAV, UFR Sciences, Université d'Angers, 2 Bld Lavoisier, 49045 Angers Cedex 01, France. Electronic address:

Insecticides were used as pest management tools for a long time. The appearance of resistant insects has led the scientific community to rethink their use and to study the mechanisms underlying the resistance in order to circumvent it. However, we know now that sublethal doses of insecticide induce many effects which should be taken into account for pest control. Read More

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December 2018

Difference in IgA1 O-glycosylation between IgA deposition donors and IgA nephropathy recipients.

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis, and disease recurrence often occurs after transplantation. On the other hands, Asymptomatic IgA deposition (IgAD) is occasionally observed in donated kidney. It is recognized that IgAD does not progress to IgAN, but the mechanism has not demonstrated yet. Read More

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December 2018

Crash histories, safety perceptions, and attitudes among Virginia bicyclists.

J Safety Res 2018 Dec 2;67:189-196. Epub 2018 Nov 2.

Department of Civil and Environmental Engineering, University of Virginia, United States. Electronic address:

Introduction: Cycling injury and fatality rates are on the rise, yet there exists no comprehensive database for bicycle crash injury data.

Method: Widely used for safety analysis, police crash report datasets are automobile-oriented and widely known to under-report bicycle crashes. This research is one attempt to address gaps in bicycle data in sources like police crash reports. Read More

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December 2018

Higher-order cycling skills among 11- to 13-year-old cyclists and relationships with cycling experience, risky behavior, crashes and self-assessed skill.

J Safety Res 2018 Dec 19;67:137-143. Epub 2018 Oct 19.

CROW, Hora plantsoon 18, 6717 LT, Ede, the Netherlands. Electronic address:

Introduction: In the Netherlands, young cyclists are extremely vulnerable in traffic, which may partly be due to their still underdeveloped higher-order cycling skill. So far, knowledge on their actual level of skill is lacking. Using a computerized test battery mimicking real-life risky traffic conditions, this study assessed the level of higher-order cycling skill in children 11 and 12 years of age and tested the hypothesis that these skills show caveats. Read More

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December 2018

Current controversies in early-stage melanoma: Questions on management and surveillance.

J Am Acad Dermatol 2019 Jan;80(1):15-25

Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah. Electronic address:

There are a number of controversies and uncertainties relating to the management and surveillance of patients with early-stage, localized (ie, stage 0, I, and II) cutaneous melanoma. While tumor stage is a critical predictor of clinical outcome and guides treatment, accurate determination of stage may be affected by the biopsy technique used and the method of sectioning before histologic review. A new molecular prognostic test is available but has not been formally incorporated into staging or treatment guidelines. Read More

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January 2019

Current controversies in early-stage melanoma: Questions on incidence, screening, and histologic regression.

J Am Acad Dermatol 2019 Jan;80(1):1-12

Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah. Electronic address:

In the first article in this continuing medical education series we review controversies and uncertainties relating to the epidemiology and initial diagnosis of localized cutaneous melanoma (ie, stage 0, I, or II). Many of these issues are unsettled because of conflicting evidence. Melanoma incidence appears to be increasing, yet its basis has not been fully explained. Read More

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January 2019
1 Read

Feasibility and clinical outcomes of ureteral stenting in the office procedural suite.

Can J Urol 2018 Dec;25(6):9596-9600

MD/PhD Program, Texas A & M Health Science Center College of Medicine, Temple, Texas, USA.

Introduction: Stent placement is a common procedure for addressing obstructive uropathy. However, lack of operating room (OR) availability can substantially delay this procedure. In this study, we sought to assess the feasibility, safety, and efficacy of this procedure in a clinical setting using nitrous oxide (N2O) and local anesthesia. Read More

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December 2018

Cranberry juice decreases disease activity in women with rheumatoid arthritis.

Nutrition 2018 Oct 10;60:112-117. Epub 2018 Oct 10.

Department of Internal Medicine,University of Londrina, Londrina, Paraná, Brazil. Electronic address:

Objectives: Studies have shown that cranberry (Vaccinium macrocarpon) has antiinflammatory and antioxidant effects; however, to our knowledge, the effects of cranberry juice consumption have not been studied in patients with rheumatoid arthritis (RA). The aim of this study was to verify the effect of cranberry juice consumption on several inflammatory biomarkers and on the disease activity of patients with RA.

Methods: A prospective study was conducted with 41 women diagnosed with RA. Read More

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October 2018
1 Read

Proteomic analysis for phenanthrene-elicited wheat chloroplast deformation.

Environ Int 2018 Dec 11;123:273-281. Epub 2018 Dec 11.

Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA 01003, USA.

The exposure of polycyclic aromatic hydrocarbons (PAHs) can cause wheat leaf chlorosis. Thus, we hypothesize that chloroplast inner structure damage is the reason for leaf chlorosis. This study was conducted with the wheat seedlings exposed to Hoagland nutrient solution containing 1. Read More

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December 2018
4 Reads

Program implementer perspectives replicating evidence based sexual reproductive health programs.

Eval Program Plann 2018 Dec 6;73:80-87. Epub 2018 Dec 6.

The Johns Hopkins Center for Child & Community Health, Johns Hopkins Bayview Medical Center, 5200 Eastern Avenue, Suite 4200, Mason F. Lord Building, Center Tower, Baltimore, MD 21224, United States.

Purpose: Explore factors affecting implementation of evidence based adolescent sexual/reproductive health programs, from the perspectives of program implementers.

Methods: In-depth interviews were conducted with 18 program implementers delivering six sexual/reproductive health programs in New Jersey. Programs were delivered among 2698 primarily African American and Hispanic adolescents in school and community-based settings. Read More

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December 2018
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Molecular simulation of the structure of folate and antifolates at physiological conditions.

J Mol Graph Model 2018 Dec 4;87:172-184. Epub 2018 Dec 4.

Laboratory of Quantum and Computational Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia, 1 James Bourchier Blvd, 1164, Sofia, Bulgaria. Electronic address:

The study is focused on description of folate and several antifolates at physiological conditions. Knowledge of the molecular structure and dynamics is important for understanding their biological activity and therapeutic application. They are modelled in saline by atomistic molecular dynamics simulations and characterized in detail. Read More

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December 2018
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Near-infrared excited cooperative upconversion in luminescent Ytterbium(ΙΙΙ) bioprobes as light-responsive theranostic agents.

Eur J Med Chem 2018 Dec 5;163:546-559. Epub 2018 Dec 5.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India. Electronic address:

Near-infrared (NIR) Ytterbium(ΙΙΙ) complexes namely [Yb(dpq)(DMF)Cl] (1), [Yb(dppz)(DMF)Cl] (2), [Yb(dpq)(ttfa)] (3) and [Yb(dppz)(ttfa)] (4) based on photosensitizing antenna: dipyrido-[3,2-d:2',3'-f]-quinoxaline (dpq), dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) and 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (Httfa), were designed as NIR bioimaging agents utilizing cooperative upconversion luminescence (CUCL) of Yb(III). Their structures, detailed photophysical properties, biological interactions, photo-induced DNA cleavage, NIR photocytotoxicity and cellular internalization and bioimaging properties were examined. Discrete mononuclear complexes adopt a seven-coordinated {LnNOCl} mono-capped octahedron (1, 2) and eight-coordinated {LnNO} distorted square antiprism geometry (3, 4) with bidentate N, N-donor dpq, dppz and O,O-donor ttfa ligands. Read More

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December 2018

Medical populism.

Soc Sci Med 2018 Dec 7;221:1-8. Epub 2018 Dec 7.

University of Canberra, Australia. Electronic address:

Medical emergencies are staple features of today's 24/7 culture of breaking news. As politics becomes increasingly stylised, audiences fragmented, and established knowledge claims contested, health crises have become even more vulnerable to politicisation. We offer the vocabulary of medical populism to make sense of this phenomenon. Read More

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December 2018
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