103,291 results match your criteria Knee Joint

[Update on the Operative Treatment of Cartilage Defects].

Z Orthop Unfall 2021 May 11. Epub 2021 May 11.

Focal cartilage defects lead to swelling, significant pain and loss of function of the affected joint. Additionally, they are linked to early onset of osteoarthritis. Often young and active patients are especially susceptible due to the high stress placed on their joints. Read More

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Leg Joint Mechanics When Hopping at Different Frequencies.

Mu Qiao

J Appl Biomech 2021 May 11:1-9. Epub 2021 May 11.

Louisiana Tech University.

Although the dynamics of center of mass can be accounted for by a spring-mass model during hopping, less is known about how each leg joint (ie, hip, knee, and ankle) contributes to center of mass dynamics. This work investigated the function of individual leg joints when hopping unilaterally and vertically at 4 frequencies (ie, 1.6, 2. Read More

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Stener-like lesions in the hand, knee and foot: a review of anatomy, mechanism of injury and imaging evaluation.

Clin Imaging 2021 May 6;76:235-246. Epub 2021 May 6.

Department of Musculoskeletal Radiology, Fleury Medicina e Saúde Higienópolis, Rua Mato Grosso 306, 1° Andar, Higienópolis, São Paulo, SP 01239-040, Brazil. Electronic address:

A Stener lesion is a displaced tear of the ulnar collateral ligament in the metacarpophalangeal joint of the thumb in which the adductor pollicis aponeurosis is positioned between the retracted ligament and the injury site, preventing natural healing. This lesion was first described in 1962, and since then, both radiologists and orthopedists have considered it important to treat surgically. Although this lesion was originally described in the thumb, this injury mechanism can occur in other joints of the hand, knee, and foot. Read More

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Subchondral bone length in knee osteoarthritis: A deep learning derived imaging measure and its association with radiographic and clinical outcomes.

Arthritis Rheumatol 2021 May 11. Epub 2021 May 11.

Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA, 02118.

Objective: Develop a bone shape measure that reflects the extent of cartilage loss and bone flattening in knee osteoarthritis (OA) and test it against estimates of disease severity.

Methods: A fast region-based convolutional neural network was trained to crop the knee joints in sagittal dual-echo steady state MRI sequences obtained from the Osteoarthritis Initiative (OAI). Publicly available annotations of the cartilage and menisci were used as references to annotate the tibia and the femur in 61 knees. Read More

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Identifying potential classification criteria for calcium pyrophosphate deposition disease (CPPD): Item generation and item reduction.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Division of Rheumatology, University of Alabama at Birmingham, Birmingham Veterans Affairs Medical Center, Birmingham, United States.

Objective: Classification criteria for calcium pyrophosphate deposition disease (CPPD) will facilitate clinical research on this common crystalline arthritis. We report on the first two phases of a four-phase process for developing CPPD classification criteria.

Methods: CPPD classification criteria development is overseen by a 12-member Steering Committee. Read More

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Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.

Objective: To determine the incidence and worsening of lumbar spine structure and low back pain (LBP) and whether they are predicted by demographic characteristics or clinical characteristics or appendicular joint osteoarthritis (OA).

Methods: Paired baseline (2003-2004) and follow-up (2006-2010) lumbar spine radiographs from the Johnston County Osteoarthritis Project were graded for osteophytes (OST), disc space narrowing (DSN), spondylolisthesis, and presence of facet joint OA (FOA). Spine OA was defined as at least mild OST and mild DSN at the same level for any level of the lumbar spine. Read More

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Superficial cartilage transverse relaxation time is associated with osteoarthritis disease progression - data from the FNIH biomarker study of the osteoarthritis initiative.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Department of Imaging and Functional Musculoskeletal Research, Institute of Anatomy and Cell Biology, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria.

Objective: To study whether layer-specific cartilage transverse relaxation time (T2), and/or longitudinal change is associated with clinically relevant knee osteoarthritis (OA) disease progression.

Methods: The FNIH biomarker consortium was a nested case-control study on 600 knees from 600 Osteoarthritis Initiative participants. Progressor knees had both medial tibiofemoral radiographic joint space width (JSW) loss (≥0. Read More

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General Safety and Tolerability of Subcutaneous Tanezumab for Osteoarthritis: A Pooled Analysis of 3 Randomized, Placebo-Controlled Trials.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Pfizer Inc, Groton, Connecticut, USA.

Objective: This pooled analysis of 3 randomized, placebo-controlled trials (16─24 week treatment; 8─24 week follow-up) assessed safety of subcutaneous tanezumab (2.5─10 mg every 8 weeks) in 1840 patients with hip or knee osteoarthritis.

Methods: Overall treatment-emergent adverse events (TEAEs) and TEAEs of abnormal peripheral sensation (APS) were prospectively assessed in 3 trials. Read More

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Arthroscopic management of unexplained pain following total knee arthroplasty.

Arch Orthop Trauma Surg 2021 May 10. Epub 2021 May 10.

Hôpital Privé de L'Estuaire, Ramsay Santé, Le Havre, France.

Introduction: Arthrofibrosis develops in 3-10% of knees after total knee arthroplasty (TKA), which may result in pain and restricted range-of-motion. Treatment options include manipulation under anaesthesia, arthroscopic debridement, and quadricepsplasty, but there is little consensus on their efficacy for treatment of unexplained pain after TKA. The purpose of this study was to report the prevalence and characteristics of unexplained pain after TKA as revealed by arthroscopic exploration, and assess the efficacy of arthroscopic procedures to relieve pain. Read More

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Making the patient voice heard in a research consortium: experiences from an EU project (IMI-APPROACH).

Res Involv Engagem 2021 May 10;7(1):24. Epub 2021 May 10.

Lygature, Jaarbeursplein 6, Utrecht, 3521 AL, The Netherlands.

APPROACH is an EU-wide research consortium with the goal to identify different subgroups of knee osteoarthritis to enable future differential diagnosis and treatment. During a 2-year clinical study images, biomarkers and clinical data are collected from people living with knee osteoarthritis and data are analyzed to confirm patterns that can indicate such different subgroups. A Patient Council (PC) has been set up at project initiation and consists of five people from Norway, The Netherlands and UK. Read More

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Usual Medical Care for Patellofemoral Pain Does Not Usually Involve Much Care: 2-Year Follow-Up in the Military Health System.

J Orthop Sports Phys Ther 2021 May 10:1-25. Epub 2021 May 10.

Discipline of Physiotherapy, School of Health Sciences, The University of Newcastle, Callaghan, Australia.

Objectives: To identify the most common type and timing of interventions used to initially manage patellofemoral pain (PFP), and if exercise therapy as an initial treatment was associated with decreased likelihood of recurrence of PFP.

Design: Retrospective cohort.

Methods: Active duty military service members (n=74,408) aged 18 to 50 years and diagnosed with PFP between 2010 and 2011 were included. Read More

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Latent Class Analysis to Predict Outcomes of Early High-Intensity Physiotherapy After Total Knee Arthroplasty Based on Longitudinal Trajectories of Walking Speed.

J Orthop Sports Phys Ther 2021 May 10:1-30. Epub 2021 May 10.

Radboud University Medical Center, Research Institute for Health Sciences, IQ Healthcare, Nijmegen, the Netherlands.

Objective: To (i) classify patients who are recovering from total knee arthroplasty (TKA) based on walking speed during an early physiotherapy program, and (ii) assess whether walking speed trajectory predicts performance on the Timed Up and Go test (TUG).

Design: Cohort study.

Methods: We included 218 patients from a 10-day physiotherapy program after TKA. Read More

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Recent Injury, Severe Radiographic Change and Lower Quadriceps Strength Increase Risk of Knee Pain Exacerbation During Walking: A Within-Person Knee-Matched Study.

J Orthop Sports Phys Ther 2021 May 10:1-28. Epub 2021 May 10.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Objective: To examine the association of knee injury, radiographic osteoarthritis severity and quadriceps strength with knee pain exacerbation during walking.

Design: Within-person knee-matched case-control study.

Methods: Participants from the Osteoarthritis Initiative who completed a 20-meter walking test at the 24-month visit were included. Read More

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Systematic review and meta-analysis of the prevalence of neuropathic-like pain and/or pain sensitisation in people with knee and hip osteoarthritis.

Osteoarthritis Cartilage 2021 May 7. Epub 2021 May 7.

Alfred Health, Melbourne VIC, Australia; School of Medicine, Monash University, Subang Jaya Selangor, Malaysia; School of Public Health and Preventive Medicine, Monash University, Australia; Alfred Health, Melbourne VIC, Australia; Department of Epidemiology and Preventative Medicine, Monash University, Melbourne VIC, Australia; Department of Epidemiology and Preventative Medicine, Monash University, Melbourne VIC, Australia; Rheumatologist and Head of Unit, Rheumatology Unit, Alfred Health, Melbourne VIC, Australia. Professor and Head of Unit, Musculoskeletal Unit, Department of Epidemiology and Preventative Medicine, Monash University, Melbourne VIC, Australia; Rheumatologist, Rheumatology Unit, Alfred Health, Melbourne VIC, Australia. Professor, Musculoskeletal Unit, Department of Epidemiology and Preventative Medicine, Monash University, Melbourne VIC, Australia. Electronic address:

Objective: To determine the prevalence of neuropathic-like pain(NP) and pain sensitisation(PS) defined by self-report questionnaires in knee and hip osteoarthritis, and whether prevalence is potentially explained by disease-severity or affected joint.

Design: MEDLINE, EMBASE, CINAHL were systematically searched(1990-April 2020) for studies describing the prevalence of NP and PS in knee and hip osteoarthritis using self-report questionnaires. Random-effects meta-analysis was performed. Read More

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Soft soled footwear has limited impact on toddler gait.

PLoS One 2021 10;16(5):e0251175. Epub 2021 May 10.

Department of Physiotherapy, Centre for Health, Exercise and Sports Medicine, School of Health Sciences, Faculty of Medicine Dentistry & Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.

The development of walking in young toddlers is an important motor milestone. Walking patterns can differ widely amongst toddlers, and are characterised by unique biomechanical strategies. This makes comparisons between newly walking toddler's and older children's walking difficult. Read More

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Incidence, Outcomes, and Prediction of Postoperative Urinary Retention After a Nonurologic Procedure.

J Am Acad Orthop Surg Glob Res Rev 2020 May;4(5):e1900149

From the Department of Urology (Dr. Abdul-Muhsin, Jakob, Dr. Navaratnam, Dr. Khan, and Dr. Humphreys), Department of Research Biostatistics (Dr. Cha and Dr. Zhang), and the Department of Orthopedic Surgery (Dr. Schwartz), Mayo Clinic Arizona, Phoenix, AZ.

Purpose: To develop a prognostic model to estimate postoperative urinary retention (POUR) after lower limb arthroplasty.

Methods: One thousand two hundred twenty patients underwent 1,374 joint replacement operations (812 knees and 562 hips) between December 2008 and May 2014. Detailed variables were collected. Read More

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Histomorphometric Quantitative Evaluation of Long-Term Risedronate Use in a Knee Osteoarthritis Rabbit Model.

Front Vet Sci 2021 22;8:669815. Epub 2021 Apr 22.

Anatomy, Animal Production and Veterinary Clinical Sciences Department, Veterinary Faculty, Universidade de Santiago de Compostela, Lugo, Spain.

Osteoarthritis (OA) treatment is a major orthopedic challenge given that there is no ideal drug capable to reverse or stop the progression of the OA. In that regard, bisphosphonates have been proposed as potential disease-modifying drugs due to their possible chondroprotective effect related to obtaining a greater subchondral bone quality. However, their effectiveness in OA is still controversial and additionally, there is little evidence focused on their long-term effect in preclinical studies. Read More

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Automatic Discoid Lateral Meniscus Diagnosis from Radiographs Based on Image Processing Tools and Machine Learning.

J Healthc Eng 2021 20;2021:6662664. Epub 2021 Apr 20.

The Digital ART Lab of School of Software, Shanghai JiaoTong University, Shanghai 200240, China.

The aim of the present study is to build a software implementation of a previous study and to diagnose discoid lateral menisci on knee joint radiograph images. A total of 160 images from normal individuals and patients who were diagnosed with discoid lateral menisci were included. Our software implementation includes two parts: preprocessing and measurement. Read More

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Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.

Front Immunol 2021 22;12:651475. Epub 2021 Apr 22.

R&D GlaxoSmithKline, Stevenage, United Kingdom.

In this study, we sought to characterize synovial tissue obtained from individuals with arthralgia and disease-specific auto-antibodies and patients with established rheumatoid arthritis (RA), by applying an integrative multi-omics approach where we investigated differences at the level of DNA methylation and gene expression in relation to disease pathogenesis. We performed concurrent whole-genome bisulphite sequencing and RNA-Sequencing on synovial tissue obtained from the knee and ankle from 4 auto-antibody positive arthralgia patients and thirteen RA patients. Through multi-omics factor analysis we observed that the latent factor explaining the variance in gene expression and DNA methylation was associated with Swollen Joint Count 66 (SJC66), with patients with SJC66 of 9 or more displaying separation from the rest. Read More

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An Overview of Telehealth in Total Joint Arthroplasty.

HSS J 2021 Feb 21;17(1):51-58. Epub 2021 Feb 21.

Adult Reconstruction and Joint Replacement Service, Hospital for Special Surgery, New York, NY, USA.

With the increase in technological advances over the years, telehealth services in orthopedic surgery have gained in popularity, yet adoption among surgeons has been slow. With the onset of the COVID-19 pandemic, however, orthopedic surgery practices nationwide have accelerated adaptation to telemedicine. Telehealth can be effectively applied to total joint arthroplasty, with the ability to perform preoperative consultations, postoperative follow-up, and telerehabilitation in a virtual, remote manner with similar outcomes to in-person visits. Read More

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February 2021

Parametric Study of a Triboelectric Transducer in Total Knee Replacement Application.

J Intell Mater Syst Struct 2021 Jan 20;32(1):16-28. Epub 2020 Aug 20.

Binghamton University, 4400 Vestal Parkway E., Binghamton, NY 13902, USA.

Triboelectric energy harvesting is a relatively new technology showing promise for biomedical applications. This study investigates a triboelectric energy transducer for potential applications in total knee replacement (TKR) both as an energy harvester and a sensor. The sensor can be used to monitor loads at the knee joint. Read More

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January 2021

Effect of post-cam design on the kinematics and contact stress of posterior-stabilized total knee arthroplasty.

Biomed Mater Eng 2021 May 6. Epub 2021 May 6.

Joint Reconstruction Center, Department of Orthopaedic Surgery, Yonsei Sarang Hospital, 10 Hyoryeong-ro, Seocho-gu, Seoul, Republic of Korea.

Background: The post-cam mechanism in the posterior-stabilized (PS) implant plays an important role, such as durability and kinematic performances, in total knee arthroplasty (TKA).

Objective: The purpose of this study was to evaluate the difference in the kinematics and contact stress of five post-cam designs, which are flat-and-flat, curve-and-curve (concave), curve-and-curve (concave and convex), helical, and asymmetrical post-cam designs, using three-dimensional finite element models.

Methods: We designed the post-cam model with five different geometries. Read More

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Radiological study of fabella in Omani subjects at a tertiary care center.

Anat Cell Biol 2021 May 10. Epub 2021 May 10.

Department of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

Ethnic diversity is associated with variability in the prevalence rates of fabella. We aimed to evaluate the prevalence and the radiological features of fabella in Omani patients. This is a retrospective analysis of hospital electronic database of patients referred for radiological investigations (radiographs and magnetic resonance imaging) of the knee, at a tertiary care referral center. Read More

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Abnormal Coagulation as a Risk Factor for Postoperative Complications After Primary and Revision Total Hip and Total Knee Arthroplasty.

J Arthroplasty 2021 Apr 28. Epub 2021 Apr 28.

Department of Orthopaedics, University of Illinois College of Medicine, Chicago, IL.

Background: Patients undergoing total joint arthroplasty (TJA) have an increased likelihood of having an abnormal coagulation profile compared with the general population. Coagulation abnormalities are often screened for before surgery and considered during perioperative planning. This study assesses a preoperative abnormal coagulation profile as a risk factor for postoperative complications after total hip arthroplasty (THA), revision THA (rTHA), total knee arthroplasty (TKA), and revision TKA (rTKA) and then examines specific coagulopathies to determine their influence on complication rates. Read More

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The association between knee joint muscle activation and knee joint moment patterns during walking in moderate medial compartment knee osteoarthritis: implications for secondary prevention.

Arch Phys Med Rehabil 2021 May 6. Epub 2021 May 6.

School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax, NS B3H 1W2, Canada; School of Physiotherapy, Dalhousie University, 5869 University Ave, Halifax, NS B3H 4R2, Canada; Affiliated Scientist Nova Scotia Health Authority, Department of Surgery, Halifax, NS B3H 3A7, Canada. Electronic address:

Objective: Determine associations between knee moment features linked to osteoarthritis (OA) progression, gait muscle activation patterns, and strength.

Design: Cross-sectional secondary analysis.

Setting: Gait laboratory. Read More

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Quantifying Patient Engagement in Total Joint Arthroplasty Using Digital Application-Based Technology.

J Arthroplasty 2021 Apr 24. Epub 2021 Apr 24.

Orthopaedic Surgery, Ascension Providence Rochester Hospital, Rochester, MI.

Background: Digital patient engagement has been suggested as a mean to increase patient activation and patient satisfaction after total joint arthroplasty. The purpose of this study was to assess patient engagement with application-based educational tools and to explore what content was most useful to patients in the perioperative period surrounding total hip arthroplasty (THA) and total knee arthroplasty (TKA), respectively.

Methods: Patients undergoing THA and TKA between October 2017 and January 2020 were enrolled to use an application-based digital technology. Read More

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Accuracy of soft tissue balancing in total knee arthroplasty using surgeon-defined assessment versus a gap-balancer or electronic sensor.

J Orthop Surg Res 2021 May 8;16(1):305. Epub 2021 May 8.

Peking University Third Hospital, Department of Orthopaedics, Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, 49 North Garden Road, Beijing, 100191, Haidian District, China.

Background: Soft tissue balancing is essential for the success of total knee arthroplasty (TKA) and is mainly dependent on surgeon-defined assessment (SDA) or a gap-balancer (GB). However, an electronic sensor has been developed to objectively measure the gap pressure. This study aimed to evaluate the accuracy of soft tissue balancing using SDA and GB compared with a sensor. Read More

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Diagnosis of knee prosthetic joint infection; aspiration and biopsy.

Knee 2021 May 5;30:249-253. Epub 2021 May 5.

Department of Microbiology, Royal Devon and Exeter Hospitals, Barrack Road, United Kingdom.

Background: Prosthetic joint infection (PJI) is a significant cause of morbidity and mortality following knee replacement surgery. The diagnosis can be challenging and is based on a combination of clinical suspicion, radiographic findings and also biochemical/ microbiological investigations. Our Aim was to review the role of aspiration and biopsy in the diagnosis of PJI in Total Knee Arthroplasty (TKA). Read More

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A review of the Turned-down Onto Pericapsular-tissue Hemisectioned Amputated Toe (TOPHAT) flap for wound coverage during ray amputations of the toes.

Foot (Edinb) 2021 Apr 20;47:101803. Epub 2021 Apr 20.

Department of Vascular and Endovascular Surgery, Singapore General Hospital, Academia Level 5, Outram Road, 169608, Singapore. Electronic address:

Introduction: Exposure of the adjacent Metatarsal-Phalangeal Joint (MTPJ) commonly occurs after application of Topical Negative Pressure Wound Therapy (TNPWT) for a ray amputation wound. This is due to mechanical soft tissue erosion or trauma to the adjacent digital artery from direct pressure effect. This results in toe gangrene requiring a ray amputation and ultimately a larger wound bed. Read More

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[Correlation of cerebrospinal fluid amyloid β-protein 42 and neurofilament light protein levels with postoperative neurocognitive dysfunction in elderly patients].

X Zhang Q Fu

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):574-578

Department of Anesthesiology, General Hospital of PLA, Beijing 100853, China.

Objective: To detect cerebrospinal fluid levels of amyloid beta- protein 42 (Aβ42) and neurofilament light protein (NFL) and explore their correlation with postoperative neurocognitive dysfunction (PNCD) in elderly patients.

Objective: A total of 90 elderly patients undergoing hip or knee replacement with joint epidural anesthesia in our Hospital between January, 2017 and December, 2018 were recruited in this study. The levels of Aβ42 and NFL in the cerebrospinal fluid were detected using ELISA. Read More

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