111,700 results match your criteria Knee Joint


Tramadol prescribed at discharge is associated with lower odds of chronic opioid use after elective total joint arthroplasty.

Reg Anesth Pain Med 2022 Jun 27. Epub 2022 Jun 27.

Department of Anesthesiology, Critical Care & Pain Management, Hospital for Special Surgery, New York City, New York, USA

Introduction: We aimed to study the association between tramadol prescribed at discharge (after elective total hip and knee arthroplasty (THA/TKA) surgery) and chronic opioid use postoperatively.

Methods: This retrospective cohort study queried the Truven MarketScan database and identified patients who underwent an elective THA/TKA surgery between 2016 and 2018 and were prescribed opioids at discharge (n=81 049). Multivariable analysis was conducted to study the association between tramadol prescription at discharge and chronic opioid use, with additional analysis adjusting for the amount of opioids prescribed in oral morphine equivalents. Read More

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6-shogaol treatment improves experimental knee OA exerting a pleiotropic effect over immune innate signaling response in chondrocytes.

Br J Pharmacol 2022 Jun 27. Epub 2022 Jun 27.

Bone and Joint Research Unit, Service of Rheumatology, IIS-Fundación Jiménez Díaz, Autonomous University of Madrid, Madrid, Spain.

Background And Purpose: The pathogenesis of osteoarthritis (OA) implicates a low-grade inflammation associated to the activation of the innate immune system. Toll like receptor (TLR) stimulation triggers the release of inflammatory mediators, which aggravate OA severity. The aim was to study the preventive effect of 6-shogaol (6S), a potential TLR4 inhibitor, on the treatment of experimental knee OA. Read More

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Automatic Grading Assessments for Knee MRI Cartilage Defects via Self-ensembling Semi-supervised Learning with Dual-Consistency.

Med Image Anal 2022 Jun 18;80:102508. Epub 2022 Jun 18.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Knee cartilage defects caused by osteoarthritis are major musculoskeletal disorders, leading to joint necrosis or even disability if not intervened at early stage. Deep learning has demonstrated its effectiveness in computer-aided diagnosis, but it is time-consuming to prepare a large set of well-annotated data by experienced radiologists for model training. In this paper, we propose a semi-supervised framework to effectively use unlabeled data for better evaluation of knee cartilage defect grading. Read More

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Performance fatigability and recovery after dynamic multi-joint maximal exercise in elbow flexors versus knee extensors.

Am J Physiol Regul Integr Comp Physiol 2022 Jun 27. Epub 2022 Jun 27.

Department of Molecular Medicine, grid.8982.bUniversity of Pavia, Pavia, Italy.

Elbow flexors (EF) and knee extensors (KE) have shown differences in performance fatigability and recovery of neuromuscular function after isometric and isotonic single-joint fatiguing contractions. However, dynamic multi-joint movements are more representative of real-world activities. The aim of the study was to assess central and peripheral mechanisms of fatigability after either arm-cranking or cycling. Read More

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Arthroscopic reconstruction of anterior cruciate ligaments with allograft: single-tunnel single-bundle versus single-tunnel double-bundle techniques.

J Orthop Traumatol 2022 Jun 27;23(1):26. Epub 2022 Jun 27.

Department of Sports Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, Guangdong, China.

Purpose: To compare the clinical results of anterior cruciate ligament (ACL) reconstruction using the single-tunnel single-bundle (STSB) technique versus the single-tunnel double-bundle (STDB) technique.

Methods: This was a retrospective, single-center, single-surgeon study based on data collected from March 2012 to June 2013. According to our inclusion/exclusion criteria, a total of 78 patients (64 males, 14 females; mean age, 25. Read More

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Postaxial hypoplasia of the lower extremity associated with congenital dislocation of the patella: A case report.

Medicine (Baltimore) 2022 Jun 24;101(25):e29283. Epub 2022 Jun 24.

Health Science Division, Division of Plastic and Reconstructive Surgery, Unit of Hip and Pelvis Orthopedic Surgery, Hospital de Traumatología y Ortopedia No. 21, Instituto Mexicano del Seguro Social (IMSS), Monterrey, N.L., México.

Rationale: Evaluation of clinical and radiologic abnormalities in patients with postaxial hypoplasia of the lower extremity (PHLE) for treatment decisions represents a major challenge, which is more complicated when PHLE is associated with congenital dislocation of the patella.

Patient Concerns: : Herein, we present the case of an 8-year-old female patient with evident length inequality in her left lower extremity and inability to walk.

Diagnoses: Radiological evaluation revealed PHLE with fibular hemimelia, proximal femoral focal deficiency, tarsal coalition, and congenital patellar dislocation of the patella. Read More

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A Newly Designed "SkyWalker" Robot Applied in Total Knee Arthroplasty: A Retrospective Cohort Study for Femoral Rotational Alignment Restoration.

Orthop Surg 2022 Jun 27. Epub 2022 Jun 27.

Chongqing Key Laboratory of Precision Medicine of Joint Surgery,Center for Joint Surgery, Southwest Hospital, Third Military University (Amy Medical University), Chongqing, China.

Objective: This study explored whether robotic arm-assisted total knee arthroplasty (RATKA) has the advantage of restoring femoral rotational alignment compared to conventional total knee arthroplasty (COTKA).

Methods: Sixty patients (45 women and 15 men) attending our department from May 2019 to December 2020 were selected and divided into two groups, with 30 patients in each group, according to whether they underwent COTKA or RATKA. Femoral rotational alignment results, such as, posterior condylar angle (PCA), patella transverse axis-femoral transepicondylar axis angle (PFA), radiological findings, such as, hip-knee-ankle angle (HKA), lateral distal femoral angle (LDFA), and medial proximal tibial angle (MPTA), and operative data (operation time, intraoperative blood loss, tourniquet time, and length of stay (LOS), and clinical outcomes, such as maximum knee flexion angle (MKFA), Knee Society Score (KSS), and Western Ontario Mac Master University Index Score (WOMAC) were compared within and between the two groups. Read More

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Risk Factors for Acute Ankle Sprains in Field-Based, Team Contact Sports: a Systematic Review of Prospective Etiological Studies.

Phys Sportsmed 2022 Jun 27. Epub 2022 Jun 27.

Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland.

Disclaimer: This manuscript is original and is not being considered for publication elsewhere. The authors listed have contributed significantly to the given text and consented to have their names appear for authorship. There are no conflicts of interest related to this research and no external financial support. Read More

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Patellar Tendon Shear Wave Velocity Is Higher and has Different Regional Patterns in Elite Competitive Alpine Skiers than in Healthy Controls.

Front Bioeng Biotechnol 2022 9;10:858610. Epub 2022 Jun 9.

Sports Medical Research Group, Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Competitive alpine skiers are exposed to enormous forces acting on their bodies-particularly on the knee joint and hence the patellar tendon - during both the off-season preparation and in-season competition phases. However, factors influencing patellar tendon adaptation and regional pattern differences between alpine skiers and healthy controls are not yet fully understood, but are essential for deriving effective screening approaches and preventative countermeasures. Thirty elite competitive alpine skiers, all members of the Swiss Alpine Ski Team, and 38 healthy age-matched controls were recruited. Read More

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Whole-body magnetic resonance imaging findings and patterns of chronic nonbacterial osteomyelitis in a series of Greek pediatric patients.

Acta Radiol Open 2022 Jun 22;11(6):20584601221106701. Epub 2022 Jun 22.

Department of Radiology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.

Background: Chronic nonbacterial osteomyelitis (CNO) is a pediatric autoinflammatory disorder presenting with sterile inflammatory bone lesions. Whole-body MRI (WBMRI) has most recently emerged for disease assessment, but data are limited.

Purpose: The purpose is to evaluate the imaging findings and patterns of CNO on WBMRI in a series of Greek pediatric patients. Read More

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The Role of Virtual Clinics in Postoperative Total Knee Replacement Surgery Follow-Up during COVID-19 Pandemic.

Adv Orthop 2022 16;2022:9558511. Epub 2022 Jun 16.

St. Carolus Bone & Joint Center, St. Carolus Hospital, Jakarta, Indonesia.

Background: The purpose of this study was to evaluate the feasibility of the virtual clinic for outpatient follow-up care after TKR surgery.

Methods: A total of 546 TKR surgeries were performed from January 2017 to December 2019. 30 patients were not able to go the hospital for routine follow-up. Read More

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Treating 'Septic' With Enhanced Antibiotics and 'Arthritis' by Mitigation of Excessive Inflammation.

Front Cell Infect Microbiol 2022 9;12:897291. Epub 2022 Jun 9.

Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States.

Bacterial infection within the synovial joint, commonly known as septic arthritis, remains a clinical challenge as it presents two concurrent therapeutic goals of reducing bacterial burden and preservation of articular cartilage from destructive host inflammation. We hypothesized that mitigation of MRSA-induced inflammatory signaling could diminish destruction of articular cartilage in the setting of septic arthritis when used in conjunction with antibiotics. Herein, we provide evidence which supports a new therapeutic notion that concurrent antimicrobial therapy to address the 'septic' component of the disease with inflammation mitigation to manage the destructive 'arthritis' component. Read More

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Assessment of Short-Term Outcomes of Total Knee Arthroplasty Performed With and Without a Tourniquet.

Cureus 2022 May 25;14(5):e25324. Epub 2022 May 25.

Department of Orthopaedics, Government Medical College, Patiala, IND.

Background: Tourniquet use has been advocated for better visualization of the surgical field as it exsanguinates most of the blood from the limbs to the central compartment. On the contrary, its use may increase postoperative pain and recovery of quadriceps function, thereby increasing the length of stay (LOS). The study aims to assess short-term outcomes of total knee arthroplasty (TKA) performed with and without a tourniquet. Read More

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Transient regional osteoporosis of the ankle with shifting bone marrow edema pattern within the joint.

Radiol Case Rep 2022 Sep 17;17(9):2983-2986. Epub 2022 Jun 17.

Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Drienerloolaan 5, 7522NB Enschede, the Netherlands.

We describe a case of bone marrow edema (BME) shifting within one ankle joint in a 35-year-old - male patient. He presented with increasing pain and no history of trauma. Clinically no local swelling was found and laboratory findings and plain x-ray studies were normal. Read More

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September 2022

Medial Patellofemoral Ligament Reconstruction: An Uncommon Solution for a Common Problem.

Int J Appl Basic Med Res 2022 Apr-Jun;12(2):144-147. Epub 2022 May 10.

Department of Orthopaedics, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karni Memorial Hospital, Kolkata, West Bengal, India.

Patellofemoral dislocations are commonly encountered knee ailment. Although majority of the patients are managed conservatively, depending on the patients' demands and predisposing factors, patients with recurrent dislocations often require surgical intervention. The main aim of any surgical procedure should be to restore the anatomy of the soft tissue as well as the bony elements. Read More

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Tibial metaphyseal cones combined with short stems perform as well as long stems in revision total knee arthroplasty.

ANZ J Surg 2022 Jun 27. Epub 2022 Jun 27.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Backgrounds: There is uncertainty around optimal tibial stem length in revision total knee arthroplasty (rTKA) utilizing a tibial trabecular metal (TM) cone. The purpose of this study was to compare: (1) functional outcomes, (2) radiographic outcomes and (3) implant survivorship in rTKA utilizing TM cones combined with either short stems (SS) or long stems (LS) at minimum 2 years follow-up.

Methods: In this retrospective, multi-centre study, patients undergoing rTKA utilizing a TM cone between 2008 and 2019 were included. Read More

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Predictors of a forgotten joint after medial fixed-bearing unicompartmental knee arthroplasty.

Knee 2022 Jun 23;37:103-111. Epub 2022 Jun 23.

Department of Orthopedics, General Hospital of Chinese PLA, No. 28 Fuxing Road, Beijing 100853, China; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing 100853, China.

Background: A forgotten joint is considered the ultimate goal of joint replacement. We aim to explore the predictive factors of a forgotten joint after fixed-bearing unicompartmental knee arthroplasty (UKA).

Methods: This retrospective cohort study used prospectively collected data from 302 cases of medial-compartment UKA with a minimum of 2-year follow-up. Read More

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The most economical arthroscopic suture fixation for tibial intercondylar eminence avulsion fracture without any implant.

J Orthop Surg Res 2022 Jun 25;17(1):327. Epub 2022 Jun 25.

Department of Orthopaedics, People's Liberation Army Joint Logistic Support Force 920Th Hospital, No. 212 Daguan Road, Xi Shan District, Kunming, 650032, Yunnan, China.

Background: Avulsion fracture of the tibial intercondylar eminence is a rare injury, which mainly occurs in adolescents aged 8-14 years and in those with immature bones. The current commonly used surgery may result in severe surgical trauma, affecting knee joint function and accompanied by serious complications. In this study, we described an all-inside and all-epiphyseal arthroscopic suture fixation technique for a patient to treat tibial intercondylar eminence fracture. Read More

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Extensor mechanism reconstruction and joint preservation surgery following a tibial tuberosity fracture in giant cell tumor of bone: A case report.

Int J Surg Case Rep 2022 Jun 20;96:107326. Epub 2022 Jun 20.

Eric Williams Medical Sciences Complex, University of the West Indies, Champ Fleur, Trinidad, West Indies.

Introduction And Importance: Pathologic fractures of the tibial tuberosity secondary to giant cell tumor of bone are rare injuries. While there are several well-described methods in the literature to reattach the tibial tuberosity, these techniques rely on good quality bone. However, in the presence of diseased and weak bone, additional factors have to be considered. Read More

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Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis.

Chin J Nat Med 2022 Jun;20(6):458-472

School of Traditional Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. It is known that aucubin (AU) exerts anti-inflammatory activity, but its effects and mechanisms in RA are unclear. This study investigated the anti-inflammatory effects and mechanisms of AU in vivo and in vitro. Read More

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Synovitis mediates the association between bone marrow lesions and knee pain in osteoarthritis: data from the Foundation for the National Institute of Health (FNIH) Osteoarthritis Biomarkers Consortium.

Osteoarthritis Cartilage 2022 Jun 21. Epub 2022 Jun 21.

Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. Electronic address:

Objectives: Although subchondral bone marrow lesions (BMLs) and synovitis have been well acknowledged as important sources of pain in knee osteoarthritis (KOA), it is unclear if synovitis plays the mediating role in the relationship between BMLs and knee pain.

Methods: We analyzed 600 subjects with magnetic resonance imaging (MRI) in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium (FNIH) cohort at baseline and 24-month. BMLs and synovitis were measured according to the MRI Osteoarthritis Knee Score (MOAKS) scoring system. Read More

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Characterization and Potential Relevance of Randomized Controlled Trial Patient Populations in Total Joint Arthroplasty in the United States: A Systematic Review.

J Arthroplasty 2022 Jun 21. Epub 2022 Jun 21.

Weill Cornell Medicine, New York, NY 10021.

Background: A substantial number of randomized controlled trial (RCT) studies in total joint arthroplasty (TJA) are published each year in the United States (US). However, it is unknown how closely the demographic and clinical characteristics of these cohorts resemble that of the US patient population undergoing TJA. Thus, the purpose of this systematic review was to evaluate the patient characteristics of published RCTs in TJA in the US and to compare these characteristics against patient cohorts from national patient databases. Read More

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Clothing condition does not affect meaningful clinical interpretation in markerless motion capture.

J Biomech 2022 Jun 11;141:111182. Epub 2022 Jun 11.

Mechanical and Materials Engineering, Queen's University, ON, Canada.

Markerless motion capture allows whole-body movements to be captured without the need for physical markers to be placed on the body. This enables motion capture analyses to be conducted in more ecologically valid environments. However, the influences of varied clothing on video-based markerless motion capture assessments remain largely unexplored. Read More

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Personalised pose estimation from single-plane moving fluoroscope images using deep convolutional neural networks.

PLoS One 2022 24;17(6):e0270596. Epub 2022 Jun 24.

Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.

Measuring joint kinematics is a key requirement for a plethora of biomechanical research and applications. While x-ray based systems avoid the soft-tissue artefacts arising in skin-based measurement systems, extracting the object's pose (translation and rotation) from the x-ray images is a time-consuming and expensive task. Based on about 106'000 annotated images of knee implants, collected over the last decade with our moving fluoroscope during activities of daily living, we trained a deep-learning model to automatically estimate the 6D poses for the femoral and tibial implant components. Read More

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Biomechanics of running: A special reference to the comparisons of wearing boots and running shoes.

PLoS One 2022 24;17(6):e0270496. Epub 2022 Jun 24.

Department of physical Medicine and Rehabilitation, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Boots are often used in sports, occupations, and rehabilitation. However, there are few studies on the biomechanical alterations after wearing boots. The current study aimed to compare the effects of running shoes and boots on running biomechanics. Read More

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Assessment of the circulatory concentrations of cathepsin D, cathepsin K, and alpha-1 antitrypsin in patients with knee osteoarthritis.

Ir J Med Sci 2022 Jun 24. Epub 2022 Jun 24.

Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Background: Evidence has shown that cysteine protease enzymes, such as cathepsin D, cathepsin A, cathepsin K, and alpha-1 antitrypsin (AAT) are involved in the chronic degenerative joint process. This study aimed to determine the potential involvement of cathepsin K, cathepsin D, and AAT in patients with osteoarthritis (OA).

Methods: This study was performed on 31 patients with knee OA and 29 age- and sex-matched healthy subjects (both with Fars ethnicity from Iran). Read More

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Lateral Patellar Dislocation: A Critical Review and Update of Evidence-Based Rehabilitation Practice Guidelines and Expected Outcomes.

JBJS Rev 2022 May 5;10(5). Epub 2022 May 5.

Department of Physical Therapy, University of Kentucky, Lexington, Kentucky.

»: Nonoperative treatment of a lateral patellar dislocation produces favorable functional results, but as high as 35% of individuals experience recurrent dislocations.

»: Medial patellofemoral ligament reconstruction is an effective treatment to prevent recurrent dislocations and yield excellent outcomes with a high rate of return to sport.

»: Both nonoperative and postoperative rehabilitation should center on resolving pain and edema, restoring motion, and incorporating isolated and multijoint progressive strengthening exercises targeting the hip and knee. Read More

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Evaluation of lower extremity gait analysis using Kinect V2 tracking system.

SICOT J 2022 24;8:27. Epub 2022 Jun 24.

Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan - Department of Rehabilitation Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.

Introduction: Microsoft Kinect V2 (Kinect) is a peripheral device of Xbox and acquires information such as depth, posture, and skeleton definition. In this study, we investigated whether Kinect can be used for human gait analysis.

Methods: Ten healthy volunteers walked 20 trials, and each walk was recorded by a Kinect and infrared- and marker-based-motion capture system. Read More

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The prevalence of musculoskeletal presentations in general practice: an epidemiological study.

Fam Pract 2022 Jun 24. Epub 2022 Jun 24.

Department of Trauma and Orthopaedics, South Tyneside District Hospital, Harton Lane, South Shields NE34 0PL, United Kingdom.

Background: It is estimated that 18.8 million people in the United Kingdom are living with a musculoskeletal (MSK) condition. It is a major cause of morbidity and a significant reason for presentation to primary care. Read More

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Case Report: Complex Treatment Using Vibroacoustic Therapy in a Patient With Co-Infection and COVID-19.

Front Med (Lausanne) 2022 7;9:893306. Epub 2022 Jun 7.

Department of Anesthesiology and Intensive Care, Astana Medical University, Nur-Sultan, Kazakhstan.

The present report highlights a case of successful treatment of a 59-year-old patient who experienced pain, swelling, hyperemia, the presence of a wound of the right knee joint, impaired function of the right lower limb, weakness, fatigue, and labored breathing. Sepsis was detected in the patient as a result of periprosthetic infection with concomitant severe COVID-19. The patient was admitted to the hospital for 59 days, with 57 days of treatment of the patient at the intensive care unit. Read More

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