19,972 results match your criteria Klebsiella Infections


Broad-Spectrum Cephalosporin-Resistant and/or Fluoroquinolone-Resistant Associated with Canine and Feline Urogenital Infections.

Antibiotics (Basel) 2020 Jul 7;9(7). Epub 2020 Jul 7.

Institute of Microbiology, University of Veterinary Medicine, 1210 Vienna, Austria.

The aim of the present study was to characterize resistant to 3rd and 4th generation cephalosporins, carbapenems and/or fluoroquinolones, isolated from dogs and cats with urogenital infections. In total, 36 strains ( ( = 28), ( = 3), , , , and (each = 1)) were included in the present study, 28 from Austria and 8 from Serbia. Isolates were characterized by a polyphasic approach including susceptibility pheno- and genotyping and microarray-based assays. Read More

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http://dx.doi.org/10.3390/antibiotics9070387DOI Listing

Breakthrough and persistent bacteremia due to serotype K1 in an immunocompetent patient.

IDCases 2020 27;21:e00893. Epub 2020 Jun 27.

Department of Infectious Diseases, Tokyo Saiseikai Central Hospital, Tokyo, Japan.

Herein, we report a case of breakthrough and persistent bacteremia due to serotype K1 in an immunocompetent 53- year-old man. He was diagnosed with pyogenic spondylitis owing to back pain and based on magnetic resonance imaging findings. On admission, several imaging studies were taken to search for other abscesses and infective endocarditis; however, there were no significant findings. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332522PMC

Difficulty in detecting low levels of polymyxin resistance in clinical isolates: evaluation of Rapid Polymyxin NP test, Colispot Test and SuperPolymyxin medium.

New Microbes New Infect 2020 Jul 25;36:100722. Epub 2020 Jun 25.

Laboratório de Pesquisa em Infecção Hospitalar, Instituto Oswaldo Cruz-FIOCRUZ, Rio de Janeiro, Brazil.

Polymyxins are important therapeutic options for treating infections, mainly those caused by carbapenem-resistant . Specific chemical characteristics of polymyxins make it difficult to perform antimicrobial susceptibility testing, especially within the clinical laboratory. Here we aimed to evaluate the performance of three phenotypic methods: Rapid NP Polymyxin Test, ColiSpot test and the SuperPolymyxin medium. Read More

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http://dx.doi.org/10.1016/j.nmni.2020.100722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334411PMC

Kpi, a chaperone-usher pili system associated with the worldwide-disseminated high-risk clone ST-15.

Proc Natl Acad Sci U S A 2020 Jul 8. Epub 2020 Jul 8.

Departamento de Microbiología, Complejo Hospitalario Universitario A Coruña, Instituto de Investigación Biomédica A Coruña, Universidad de A Coruña 15006 A Coruña, Spain;

Control of infections caused by carbapenem-resistant continues to be challenging. The success of this pathogen is favored by its ability to acquire antimicrobial resistance and to spread and persist in both the environment and in humans. The emergence of clinically important clones, such as sequence types 11, 15, 101, and 258, has been reported worldwide. Read More

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http://dx.doi.org/10.1073/pnas.1921393117DOI Listing

Modulation of neutrophil extracellular traps release by Klebsiella pneumoniae.

J Leukoc Biol 2020 Jul 8. Epub 2020 Jul 8.

Laboratorio de Fisiología de los Procesos Inflamatorios, Instituto de Medicina Experimental (IMEX)-CONICET/Academia Nacional de Medicina, CABA, Argentina.

One of the main bactericidal mechanisms of polymorphonuclear neutrophils (PMN) is the release of neutrophil extracellular traps (NETs), which capture and destroy pathogens. Klebsiella pneumoniae (Kpn) producer of carbapenemase (KPC) and belonging to the sequence type 258 (ST258), is a hyper epidemic clone that causes a large number of infections worldwide associated with high persistence and mortality. It is necessary to investigate the interaction of Kpn KPC with the immune system to improve prevention and treatment of infections mediated by this bacterium. Read More

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http://dx.doi.org/10.1002/JLB.4MA0620-099RDOI Listing

Frequency and antimicrobial susceptibility of bacteria causing bloodstream infections in pediatric patients from United States (US) medical centers (2014-2018): therapeutic options for multidrug-resistant bacteria.

Diagn Microbiol Infect Dis 2020 Jun 13;98(2):115108. Epub 2020 Jun 13.

JMI Laboratories, North Liberty, Iowa, USA.

Studies evaluating large series of pediatric patients with bloodstream infections (BSIs) are scarce. We evaluated the frequency and antimicrobial susceptibility of organisms isolated from pediatric patients with BSI and therapeutic options for BSI caused by multidrug-resistant (MDR) organisms. A total of 2423 organisms were consecutively collected from 33 US medical centers between 2014 and 2018, and susceptibility was tested by reference broth microdilution methods. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2020.115108DOI Listing

Participation of the IL-10RB Related Cytokines, IL-22 and IFN-λ in Defense of the Airway Mucosal Barrier.

Front Cell Infect Microbiol 2020 19;10:300. Epub 2020 Jun 19.

Department of Pediatrics, Columbia University Medical Center, New York, NY, United States.

The airway epithelial barrier is a major barrier protecting against clinically significant infections of the lung. Its integrity is often compromised due to mechanical, chemical, or infectious causes. Opportunistic bacterial pathogens are poised to cause parenchymal infection and become difficult to eradicate due to adaptive metabolic changes, biofilm formation, and the acquisition of antimicrobial resistance and fitness genes. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318800PMC

A Novel Cecropin D-Derived Short Cationic Antimicrobial Peptide Exhibits Antibacterial Activity Against Wild-Type and Multidrug-Resistant Strains of and .

Evol Bioinform Online 2020 26;16:1176934320936266. Epub 2020 Jun 26.

Valle del Cauca Departmental Secretary of Health, Gobernación del Valle del Cauca, Cali, Colombia.

Infections caused by multidrug-resistant (MDR) and are a serious worldwide public health concern due to the ineffectiveness of empirical antibiotic therapy. Therefore, research and the development of new antibiotic alternatives are urgently needed to control these bacteria. The use of cationic antimicrobial peptides (CAMPs) is a promising candidate alternative therapeutic strategy to antibiotics because they exhibit antibacterial activity against both antibiotic susceptible and MDR strains. Read More

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http://dx.doi.org/10.1177/1176934320936266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323284PMC

Amiodarone that has antibacterial effect against human pathogens may represent a novel catheter lock.

Acta Microbiol Immunol Hung 2020 Jul 6. Epub 2020 Jul 6.

1Department of Medical Microbiology, Medical School, University of Pecs, Pecs, Hungary.

Infection is one of the most feared hospital-acquired complications. Infusion therapy is frequently administered through a central line. Infusions facilitating bacterial growth may be a source of central line-associated bloodstream infections. Read More

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http://dx.doi.org/10.1556/030.2020.01144DOI Listing

Assessment of Health Care Exposures and Outcomes in Adult Patients With Sepsis and Septic Shock.

JAMA Netw Open 2020 Jul 1;3(7):e206004. Epub 2020 Jul 1.

Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Importance: Current information on the characteristics of patients who develop sepsis may help in identifying opportunities to improve outcomes. Most recent studies of sepsis epidemiology have focused on changes in incidence or have used administrative data sets that provided limited patient-level data.

Objective: To describe sepsis epidemiology in adults. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.6004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341174PMC

Containing Carbapenemase-producing Klebsiella pneumoniae in an endemic setting.

Antimicrob Resist Infect Control 2020 Jul 6;9(1):102. Epub 2020 Jul 6.

First Department of Medicine, Medical School, "Laiko" General Hospital, National and Kapodistrian University of Athens, 75, 11527, Athens, Greece.

Background: Carbapenemase-producing K. pneumoniae (CP-Kp) has been established as important nosocomial pathogen in most tertiary care hospitals in Greece. The aim of the present study was to examine the impact of an enhanced infection control program on the containment of CP-Kp in a haematology unit where the incidence of CP-Kp infections was high. Read More

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http://dx.doi.org/10.1186/s13756-020-00766-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339575PMC

Evidence of anti- K. pneumoniae biofilm activity of novel Entrococcus faecalis enterocin GLHM.

Microb Pathog 2020 Jul 3:104366. Epub 2020 Jul 3.

Department of Biology, College of Science, Mustansiryah University, Iraq.

Many enterocins were produced from the lactic acid bacteria, Enterococcus faecalis, they belonged to different types of bacteriocins and have different characteristics. The present study aimed to search for another enterocin and test its ability to inhibit Klebsiella pneumoniae biofilm as compared with the most effective antibacterial agent. E. Read More

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http://dx.doi.org/10.1016/j.micpath.2020.104366DOI Listing

Phenotypic synergy testing of ceftazidime-avibactam with aztreonam in a university hospital having high number of metallobetalactamase producing bacteria.

Infect Dis (Lond) 2020 Jul 6:1-7. Epub 2020 Jul 6.

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Ceftazidime-avibactam combination with aztreonam and role of rapid synergy reporting has not been widely evaluated. Also the synergy correlation with various betalactamases has not been widely studied. We studied phenotypic synergy testings and molecular detection of betalactamases in our university hospital where we have large number of mellatobetalactmase producing bacteria. Read More

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http://dx.doi.org/10.1080/23744235.2020.1788224DOI Listing

Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.

Front Microbiol 2020 17;11:1273. Epub 2020 Jun 17.

Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.

The presence of extended-spectrum β-lactamase (ESBL)-producing bacteria in environmental sources has been reported worldwide and constitutes a serious risk of community-acquired infections with limited treatment options. The current study aimed to explore the presence of these worrisome bacteria in a pond located at the Norwegian University of Life Sciences in Ås, Norway. A total of 98 bacterial isolates survived growth on selective chromogenic media and were identified by 16S rRNA Sanger sequencing. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311804PMC

Hypervirulence Markers Among Non-ST11 Strains of Carbapenem- and Multidrug-Resistant Isolated From Patients With Bloodstream Infections.

Front Microbiol 2020 18;11:1199. Epub 2020 Jun 18.

Shenzhen Institute of Respiratory Diseases, Second Clinical Medical College (Shenzhen People's Hospital), Jinan University; First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology, Shenzhen, China.

Multidrug-resistant and hypervirulent (hvKP) have traditionally been considered two individual populations; however, strains displaying both phenotypes have emerged during the recent decade. Understanding the genotypic and phenotypic basis of the convergence could be of clinical importance. In this study, we aimed to evaluate the pathogenicity associated with different combinations of genotypes (i. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314899PMC

Moving away from traditional antibiotic treatment: can macrocyclic lactones from marine macroalga-associated heterotroph be the alternatives?

Appl Microbiol Biotechnol 2020 Jul 3. Epub 2020 Jul 3.

Crustacean Fisheries Division, Central Marine Fisheries Research Institute, Ernakulam North, P.B. No. 1603, Cochin, India.

Intertidal red algae Hypnea valentiae associated Bacillus amyloliquefaciens MTCC 12716 revealed potential inhibitory effects on the growth of drug-resistant pathogens. In the genome of B. amyloliquefaciens MTCC 12716, biosynthetic gene clusters encoding antibacterial metabolites were predicted, which might be expressed and contributed to the broad-spectrum anti-infective activity. Read More

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http://dx.doi.org/10.1007/s00253-020-10658-0DOI Listing

Genomic analysis of multidrug-resistant CTX-M-15-positive Klebsiella pneumoniae belonging to the highly successful ST15 clone isolated from a dog with chronic otitis.

J Glob Antimicrob Resist 2020 Jun 30. Epub 2020 Jun 30.

One Health Brazilian Resistance Project (OneBR), Brazil; Department of Microbiology, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil. Electronic address:

Background: Extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae have been increasingly reported worldwide as frequent cause of human and animal infections. K. pneumoniae belonging to the K24 capsular serotype and sequence type (ST) ST15 has been considered a global successful clone responsible for the spread of bla gene. Read More

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http://dx.doi.org/10.1016/j.jgar.2020.06.017DOI Listing

Neurotoxicity Despite a Renal Function Adjusted Cefepime Regimen: A Case Study.

Ther Drug Monit 2020 Jun 29. Epub 2020 Jun 29.

Department of Pharmacology and Toxicology, CHU Limoges, F-87000 Limoges, France.

An 83-year-old man, presenting decreased renal function (estimated glomerular filtration rate 21 mL/min/1.73 m), was treated for a bone and joint infection (on a trans-metatarsal right foot amputation) caused by Klebsiella Pneumonia sensitive to cefepime. The starting dose (1 g bid) was based on recommendations for patients presenting severe infections. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000786DOI Listing

Successful treatment of a patient with cutaneous co-infection caused by Mucor irregularis and Klebsiella pneumoniae.

An Bras Dermatol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology and Venereology, First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, China. Electronic address:

The authors report a rare case of primary cutaneous mucormycosis caused by Mucor irregularis and cutaneous Klebsiella pneumoniae infections in a 67-year-old Chinese woman. After the administration of liposomal amphotericin B combined with cefoperazone/sulbactam sodium, the patient recovered. Invasive fungal infection combined with cutaneous bacterial infection should receive attention. Read More

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http://dx.doi.org/10.1016/j.abd.2020.03.004DOI Listing

Nosocomial Infections in Gastrointestinal Cancer Patients: Bacterial Profile, Antibiotic Resistance Pattern, and Prognostic Factors.

Cancer Manag Res 2020 25;12:4969-4979. Epub 2020 Jun 25.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.

Background: Cancers of the gastrointestinal (GI) tract and its associated excretory glands are one of the most common causes of cancer-related death worldwide, and these patients are more likely to developing nosocomial infections due to immunodeficiency.

Objective: To explore the bacterial profile, antibiotic resistance pattern, and prognostic factors of nosocomial infections in hospitalized GI cancer patients.

Methods: All electronic medical records of nosocomial infection episodes in hospitalized GI cancer patients were retrospectively reviewed. Read More

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http://dx.doi.org/10.2147/CMAR.S258774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323960PMC

Bacterial associated urinary tract infection, risk factors, and drug susceptibility profile among adult people living with HIV at Haswassa University Comprehensive Specialized Hospital, Hawassa, Southern Esthiopia.

Sci Rep 2020 Jul 1;10(1):10790. Epub 2020 Jul 1.

School of Medical Laboratory Science, Hawassa University College of Medicine and Health Sciences, Awassa, Ethiopia.

People living with human immunodeficiency virus (HIV) are more likely to develop urinary tract infections (UTI) due to the suppression of their immunity. The aim of this study was to determine the prevalence, risk factors of UTI, and drug susceptibility pattern of bacteria isolated among peoples infected with HIV. A hospital-based cross-sectional study was conducted among 224 HIV positive individuals attending Hawassa University Comprehensive Specialized Hospital (HUCSH) from September 17 to November 16, 2018. Read More

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http://dx.doi.org/10.1038/s41598-020-67840-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330024PMC

Detection of several carbapenems resistant and virulence genes in classical and hyper-virulent strains of Klebsiella pneumoniae isolated from hospitalized neonates and adults in Khartoum.

BMC Res Notes 2020 Jul 1;13(1):312. Epub 2020 Jul 1.

Biochemistry Department, Faculty of Sciences, King Abdulaziz University, Jeddah, 21452, Saudi Arabia.

Objective: Klebsiella pneumoniae (K. pneumoniae) involves both community-acquired and nosocomial infections. It is responsible for a wide variety of infections, including infections of the urinary tract, pneumonia, bacteremia, meningitis, wound infection and purulent abscesses. Read More

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http://dx.doi.org/10.1186/s13104-020-05157-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328261PMC

Prevalence and Antibiogram of Urinary Tract Infections in Renal Transplant Recipients at a Tertiary Care Hospital in North India.

J Assoc Physicians India 2020 May;68(5):30-31

Chairman and Head of Department, Department of Clinical Microbiology and Immunology, Sir Ganga Ram Hospital, New Delhi.

Introduction: Although, urinary tract infections (UTI) remain the most common cause of mortality and morbidity in renal allograft recipients, there is scarce data from India on the etiology and antibiogram of UTI post kidney transplantation. Therefore, the current study was undertaken to evaluate the prevalence, etiology and the antibiogram of pathogens causing UTI in this cohort.

Methods: Renal allograft recipients enrolled during the study period were screened for UTI by standard microscopy and routine culture on the day of admission and subsequently every 3rd day post-surgery till discharge. Read More

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Making and breaking leupeptin protease inhibitors in pathogenic gammaproteobacteria.

Angew Chem Int Ed Engl 2020 Jul 1. Epub 2020 Jul 1.

Yale, Chemistry and Microbial Pathogenesis, P.O. Box 27392, 06516-7392, West Haven, UNITED STATES.

Leupeptin is a bacterial small molecule that is used worldwide as a protease inhibitor. However, its biosynthesis and genetic distribution remain unknown. Here, we identified a family of leupeptins in gammaproteobacterial pathogens, including Photorhabdus, Xenorhabdus, and Klebsiella species, amongst others. Read More

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http://dx.doi.org/10.1002/anie.202005506DOI Listing

Recent advances in tackling microbial multidrug resistance with essential oils: combinatorial and nano-based strategies.

Crit Rev Microbiol 2020 Jul 1:1-20. Epub 2020 Jul 1.

Department of Pharmacognosy, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.

The emergence of multidrug resistant pathogens is a great challenge to the medical field and a major global health threat requiring novel therapeutic strategies. Among plant products, essential oils have significant antimicrobial properties that make them promising agents in the fight against drug resistant human pathogens. The aim of the present review was to highlight the most important essential oil-based antimicrobial strategies as revealed by recent studies. Read More

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http://dx.doi.org/10.1080/1040841X.2020.1782339DOI Listing

UPΦ phages, a new group of filamentous phages found in several members of .

Virus Evol 2020 Jan 22;6(1):veaa030. Epub 2020 Jun 22.

Department of Biology, Loyola University Chicago, 1032 W Sheridan Rd, Chicago, IL 60660, USA.

Filamentous phages establish chronic infections in their bacterial hosts, and new phages are secreted by infected bacteria for multiple generations, typically without causing host death. Often, these viruses integrate in their host's genome by co-opting the host's XerCD recombinase system. In several cases, these viruses also encode genes that increase bacterial virulence in plants and animals. Read More

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http://dx.doi.org/10.1093/ve/veaa030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307601PMC
January 2020

Serotyping of and Its Relation with Capsule-Associated Virulence Genes, Antimicrobial Resistance Pattern, and Clinical Infections: A Descriptive Study in Medical Practice.

Infect Drug Resist 2020 24;13:1971-1980. Epub 2020 Jun 24.

Department of Infectious Disease, School of Medicine, Shahroud University of Medical Science, Shahroud, Iran.

Objective: , one of the clinical superbugs, causes diverse infections because of its variable capsular antigens. This study focused on and aimed to assess any correlation between capsular serotype, capsule-associated virulence genes, and evaluate its resistance to conventional antibiotics in order to gain insight into any regional differences.

Materials And Methods: A total of 61 collected from various clinical specimens were confirmed genotypically. Read More

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http://dx.doi.org/10.2147/IDR.S243984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321687PMC

Plasmid Profiling and Occurrence of β-Lactamase Enzymes in Multidrug-Resistant Uropathogenic in Kathmandu, Nepal.

Infect Drug Resist 2020 23;13:1905-1917. Epub 2020 Jun 23.

Central Department of Microbiology, Tribhuvan University, Kathmandu, Nepal.

Introduction: Extended-spectrum β-lactamases (ESBL) among Gram-negative bacteria, predominantly (), in Nepal, have been rising. The main objectives of this study were to determine the prevalence of uropathogenic , antibiotic resistance, ESBLs, ABLs (AmpC type β-lactamases), MBLs (metallo-β-lactamases) and KPCs ( carbapenemases) and their correlation with plasmid profiling patterns among patients with urinary tract infections in a tertiary hospital in Kathmandu, Nepal.

Methods: The mid-stream urine samples collected from patients were inoculated in cystine-lactose-electrolyte-deficient (CLED) agar plates. Read More

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http://dx.doi.org/10.2147/IDR.S250591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320882PMC

Characterization of a Novel -Bearing Plasmid in ST395 of Chicken Origin.

Infect Drug Resist 2020 16;13:1781-1784. Epub 2020 Jun 16.

Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.

The emergence of mobile colistin resistance genes undermines the efficacy of colistin as the last-resort drug for multi-drug resistance infections and constitutes a great public health concern. Plasmids play a critical role in the transmission of genes among bacteria. One colistin-resistant strain of chicken origin was collected and analyzed by antimicrobial susceptibility testing, PCR, conjugation assay and S1-PFGE. Read More

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http://dx.doi.org/10.2147/IDR.S256544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305932PMC

Phenotypic and Genomic Characterization of Virulence Heterogeneity in Multidrug-Resistant ST11 During Inter-Host Transmission and Evolution.

Infect Drug Resist 2020 10;13:1713-1721. Epub 2020 Jun 10.

Peking Union Medical College, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Background: Multidrug-resistant (MDR) ST11 hypervirulent (hvKp) is emerging in China.

Purpose: The aim of this study was to track the transmission and evolution of hvKp.

Materials And Methods: A retrospective study focused on Kp infection was conducted. Read More

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http://dx.doi.org/10.2147/IDR.S243836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293908PMC

Case Report of Primary Lung Abscesses Due to Hypervirulent (Serotype K2, Sequence Type 375): an Emerging Isolate in Okinawa, Japan.

Infect Drug Resist 2020 10;13:1691-1695. Epub 2020 Jun 10.

Department of Infectious, Respiratory and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan.

Hypervirulent (HV-KP) is typically associated with community-acquired liver abscess and bacteremia with metastatic infection; however, primary lung abscess (PLA) caused by HV-KP is rare, with only one such case report to date. A 69-year-old man with a history of diabetes mellitus (DM) was admitted to hospital complaining of slight bloody sputum. Chest imaging showed multiple consolidations with cavities in both lung fields. Read More

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http://dx.doi.org/10.2147/IDR.S252251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293903PMC

Neonatal septicemia at intensive care unit, Ayder Comprehensive Specialized Hospital, Tigray, North Ethiopia: Bacteriological profile, drug susceptibility pattern, and associated factors.

PLoS One 2020 30;15(6):e0235391. Epub 2020 Jun 30.

Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, College of Health Sciences, Mekelle University, Mekelle, Tigray Region, Ethiopia.

Background: Neonatal septicemia is a life threatening medical emergency that requires timely detection of pathogens with urgent rational antibiotics therapy.

Methods: A cross-sectional study was conducted between March 2017 to September 2018 among 317 septicemia suspected neonates at neonatal intensive care unit, Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, North Ethiopia. A 3 mL of blood was collected from each participant. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326223PMC

Treatment of recurrent urinary tract infections in a 60-year-old kidney transplant recipient. The use of phage therapy.

Transpl Infect Dis 2020 Jun 29:e13391. Epub 2020 Jun 29.

Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 59 Nowogrodzka Street, 02-006, Warsaw, Poland.

Background: We would like to demonstrate the difficulty of treatment in a patient after kidney transplantation (KTX) who developed chronic urinary tract infection (UTI) with a multi-drug resistant ESBL-producing Klebsiella pneumoniae. The patient underwent several treatment interventions including supportive therapy with bacteriophages.

Case Presentation: This article presents a case of a 60-year-old patient after KTX repeatedly admitted to the hospital with recurrent UTIs caused by ESBL-producing Klebsiella pneumoniae showing variable susceptibility to carbapenems and full susceptibility to colistin only. Read More

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http://dx.doi.org/10.1111/tid.13391DOI Listing

Impact of antibiotic prescription on the resistance of Klebsiella pneumoniae at a tertiary hospital in China, 2012-2019.

Am J Infect Control 2020 Jun 26. Epub 2020 Jun 26.

Department of Pharmacy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

Background: The incidence of Klebsiella pneumoniae (KP) infections is worrisome. Previous studies have shown that increased antibiotic treatment might affect the resistance profile of this organism. The objective of this study was to describe the resistance profile of KP strains and to correlate it with antibiotics consumption. Read More

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http://dx.doi.org/10.1016/j.ajic.2020.06.189DOI Listing

Intra-Abdominal Infections by Carbapenemase-Producing in a Surgical Unit: Counting Mortality, Stay, and Costs.

Surg Infect (Larchmt) 2020 Jun 26. Epub 2020 Jun 26.

Department of General Surgery, Hospital Universitario La Princesa, Madrid, Spain.

Carbapenemase-producing (CPE)-related infections are a problem in public health at present, including intra-abdominal infections (IAI) and surgical populations. The aim of this study was to determine mortality and related risk factors, length of stay (LOS,) and costs for CPE-IAI in surgical patients. Review of CPE-related IAI acquired during admission in a general surgery department from January 2013 to December 2018. Read More

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http://dx.doi.org/10.1089/sur.2020.137DOI Listing

The Diversity of Lipopolysaccharide (O) and Capsular Polysaccharide (K) Antigens of Invasive in a Multi-Country Collection.

Front Microbiol 2020 12;11:1249. Epub 2020 Jun 12.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.

is a common cause of sepsis and is particularly associated with healthcare-associated infections. New strategies are needed to prevent or treat infections due to the emergence of multi-drug resistant . The goal of this study was to determine the diversity and distribution of O (lipopolysaccharide) and K (capsular polysaccharide) antigens on a large (>500) global collection of strains isolated from blood to inform vaccine development efforts. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303279PMC
June 2020
3.941 Impact Factor

Molecular mechanisms and prevalence of colistin resistance of Klebsiella pneumoniae in the Middle East region: A review over five last years.

J Glob Antimicrob Resist 2020 Jun 23. Epub 2020 Jun 23.

Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

The increasing prevalence of multidrug-resistant (MDR) Klebsiella pneumoniae is a serious clinical and public health problem, and colistin is the last-resort treatment option for MDR infections. However, resistance to colistin has been increasingly reported in the world, such as the Middle East region, where antibiotics are used more in the human and agriculture industry. In this study, we reviewed the available data on the molecular mechanisms and prevalence of colistin resistance of K. Read More

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http://dx.doi.org/10.1016/j.jgar.2020.06.009DOI Listing

Molecular tracking of pathogens in central venous catheter.

J Vasc Access 2020 Jun 26:1129729820934354. Epub 2020 Jun 26.

Department of Social and Preventive Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Background: Central venous catheter-related bloodstream infection is an important adverse event in health care. Molecular methods are not yet substitutive of microbiological in the detection of the pathogens responsible for the infection, but they can help in the epidemiological characterization.

Aim: To detect bacteria by polymerase chain reaction, from material extracted from the tip of central catheters of patients suspected of infection at the intensive care unit. Read More

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http://dx.doi.org/10.1177/1129729820934354DOI Listing

First report of plasmid-mediated colistin resistance mcr-8.1 gene from a clinical Klebsiella pneumoniae isolate from Lebanon.

Antimicrob Resist Infect Control 2020 Jun 26;9(1):94. Epub 2020 Jun 26.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos Campus, P.O. Box 36, Byblos, Lebanon.

Colistin is considered as a last resort treatment for infections caused by multidrug-resistant Enterobacteriaceae. Plasmid-mediated mobile colistin resistance (mcr) genes contributed to the global spread of colistin resistance. This is the first report of plasmid-mediated colistin resistance mcr-8 gene from a clinical Klebsiella pneumoniae K9 isolate recovered from Lebanon. Read More

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http://dx.doi.org/10.1186/s13756-020-00759-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318401PMC

Bloodstream Infections due to Carbapenem-Resistant : A Single-Center Retrospective Study on Risk Factors and Therapy Options.

Microb Drug Resist 2020 Jun 23. Epub 2020 Jun 23.

Department of Respiratory Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

We aimed to compare efficacy of different patterns of antibiotics and explore the risk factors related to mortality in patients with bloodstream infections (BSIs) due to carbapenem-resistant (CRKP). This study retrospectively included 89 patients with BSIs due to CRKP with complete data during the year of 2018 in the First Affiliated Hospital of Zhejiang University School of Medicine. Overall, the 28-day mortality was 47. Read More

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http://dx.doi.org/10.1089/mdr.2019.0455DOI Listing

Amoxicillin Increased Functional Pathway Genes and Beta-Lactam Resistance Genes by Pathogens Bloomed in Intestinal Microbiota Using a Simulator of the Human Intestinal Microbial Ecosystem.

Front Microbiol 2020 4;11:1213. Epub 2020 Jun 4.

College of Environmental Science and Engineering, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Nankai University, Tianjin, China.

Antibiotics are frequently used to treat bacterial infections; however, they affect not only the target pathogen but also commensal gut bacteria. They may cause the dysbiosis of human intestinal microbiota and consequent metabolic alterations, as well as the spreading of antibiotic resistant bacteria and antibiotic resistance genes (ARGs). experiments by simulator of the human intestinal microbial ecosystem (SHIME) can clarify the direct effects of antibiotics on different regions of the human intestinal microbiota, allowing complex human microbiota to be stably maintained in the absence of host cells. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287123PMC
June 2020
3.941 Impact Factor

Activity of Omadacycline and Other Tetracyclines Against Contemporary Gram-Negative Pathogens from New York City Hospitals.

Microb Drug Resist 2020 Jun 22. Epub 2020 Jun 22.

Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA.

Antibiotic-resistant Enterobacteriaceae and are problematic pathogens, with few treatment options for multidrug-resistant (MDR)- and few oral options for extended spectrum β-lactamase (ESBL)-producing and MDR-Enterobacteriaceae. Omadacycline, a newer tetracycline derivative, has activity against some of these pathogens. We tested the activity of omadacycline against a contemporary collection of over 2,600 consecutive unique clinical isolates of Enterobacteriaceae and , a previous collection of carbapenem-resistant and from a surveillance study in 2013-2014, and a group of and isolates with previously defined resistance mechanisms. Read More

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http://dx.doi.org/10.1089/mdr.2019.0423DOI Listing

Identification of plasmid IncQ1 and NTEKPC-IId harboring bla KPC-2 in isolates from Klebsiella pneumoniae infections in patients from Recife-PE, Brazil.

Rev Soc Bras Med Trop 2020 22;53:e20190526. Epub 2020 Jun 22.

Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Recife, PE, Brasil.

Introduction: This study investigated the genetic environment of bla KPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates.

Methods: Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using polymerase chain reaction and plasmid DNA sequencing.

Results: The bla KPC-2 gene was located between ISKpn6 and a resolvase tnpR in the non-Tn4401 element (NTEKPC-IId). Read More

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http://dx.doi.org/10.1590/0037-8682-0526-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310361PMC

Stool Samples of Acute Diarrhea Inpatients as a Reservoir of ST11 Hypervirulent KPC-2-Producing Klebsiella pneumoniae.

mSystems 2020 Jun 23;5(3). Epub 2020 Jun 23.

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

The emergence and spread of carbapenem-resistant hypervirulent sequence type 11 (ST11-CR-HvKP) in China are a great concern in the public health community. However, the underlying mechanism that enables its wide dissemination in China remains unclear. Here, we investigated the prevalence of carriage of carbapenemase-producing (CPE) among inpatients with diarrhea in a teaching hospital over 1 year to identify ST11-CR-HvKP reservoirs and to understand the genetic background and plasmid profiles of these pathogens. Read More

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http://dx.doi.org/10.1128/mSystems.00498-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311318PMC

Determining the burden of infectious diseases caused by carbapenem-resistant gram-negative bacteria in Spain.

Enferm Infecc Microbiol Clin 2020 Jun 21. Epub 2020 Jun 21.

Omakase Consulting S.L., Barcelona, Spain. Electronic address:

Objective: To estimate the burden of nosocomial infections induced by carbapenem resistant Gram-negative (CRGN) pathogens in Spain, focusing on both the clinical and economic impact.

Methods: The burden of disease was estimated using data from 2017 according to the availability of data sources. The impact, both clinical and economic, of the most frequent CRGN nosocomial infections (those produced by Klebsiella pneumoniae, Pseudomonasaeruginosa and Acinetobacter baumannii) was analysed. Read More

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http://dx.doi.org/10.1016/j.eimc.2020.04.009DOI Listing

First report of -, -, and co-harboring foodborne .

Antimicrob Agents Chemother 2020 Jun 22. Epub 2020 Jun 22.

Laboratory of Food Microbiology and Hygiene, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan

Carbapenem and colistin antibiotics are often the last resort treatment for severe infections caused by multidrug-resistant bacteria (1-3).…. Read More

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http://dx.doi.org/10.1128/AAC.00882-20DOI Listing

Pharmacodynamics of Fosfomycin Against Carbapenem-resistant .

Antimicrob Agents Chemother 2020 Jun 22. Epub 2020 Jun 22.

Department of Pharmacy, Department of Microbiology, Department of Infectious DiseasesSingapore General Hopsital, Singapore; Outram Road, Singapore 169608

The increase of carbapenem-resistant Enterobacterales (CRE) and lack of therapeutic options due to scarcity of new antibiotics has sparked interest towards the use of intravenous fosfomycin against systemic CRE infections. We aimed to investigate the pharmacodynamics of fosfomycin against carbapenem-resistant and Time-kill studies and population analysis profiles were performed with eight clinical CRE isolates, which were exposed to fosfomycin concentrations ranging from 0.25 to 2048mg/L. Read More

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http://dx.doi.org/10.1128/AAC.00536-20DOI Listing

Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection: A single-center retrospective observational study in China.

Hepatobiliary Pancreat Dis Int 2020 Jun 7. Epub 2020 Jun 7.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China.

Background: Infections still represent the main factors influencing morbidity and mortality following liver transplantation. This study aimed to evaluate the incidence and risk factors for infection and survival after liver transplantation.

Methods: We retrospectively examined medical records in 210 liver recipients who underwent liver transplantation between April 2015 and October 2017 in our hospital. Read More

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http://dx.doi.org/10.1016/j.hbpd.2020.06.001DOI Listing
June 2020
1.167 Impact Factor

Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Škorničk.

Antibiotics (Basel) 2020 Jun 18;9(6). Epub 2020 Jun 18.

Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.

The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antiviral activities of essential oils from the leaves, rhizomes, and whole plant of were investigated. The GC/MS analysis showed that β-pinene, -β-caryophyllene, and α-humulene were found at high concentrations in the essential oils. Read More

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http://dx.doi.org/10.3390/antibiotics9060334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344524PMC

Carbapenem Resistance Conferred by OXA-48 in K2-ST86 Hypervirulent Klebsiella pneumoniae, France.

Emerg Infect Dis 2020 Jul;26(7):1529-1533

We recovered 2 carbapenem-resistant K2-ST86 hypermucoviscous Klebsiella pneumoniae isolates from patients in France. The isolates had genetic attributes of hypervirulent K. pneumoniae but differed in ability to cause mouse lethality. Read More

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http://dx.doi.org/10.3201/eid2607.191490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323517PMC