34,327 results match your criteria Klebsiella Infections


Influence of various uropathogens on crystallization of urine mineral components caused by Proteus mirabilis.

Res Microbiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biology of Bacteria, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland. Electronic address:

Infectious urolithiasis is a consequence of long-standing urinary tract infections with urease-positive bacteria, especially Proteus spp. However, because of the often mixed nature of urinary tract infections, in the case of urinary stones formation, several species of bacteria may be involved in the process. The purpose of the study was to determine the impact of the bacterial species: Escherichia coli, Klebsiella pneumoniae, Providencia stuartii, Pseudomonas aeruginosa and Staphylococcus aureus on the crystallization caused by Proteus mirabilis. Read More

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December 2018
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A simple DNAzyme-based fluorescent assay for Klebsiella pneumoniae.

Chembiochem 2018 Dec 6. Epub 2018 Dec 6.

University of California Irvine, Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Edwards Lifesciences Center for Advanced Cardiovascular Technology, Biomedical Engineering, 92697, Irvine, UNITED STATES.

Pathogenic bacteria pose a serious public health threat. Rapid and cost effective detection of such bacteria remains a major challenge. Here, we present a DNAzyme-based fluorescent paper sensor for Klebsiella pneumoniae. Read More

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December 2018
2 Reads

CG258 Klebsiella pneumoniae isolates without β-lactam resistance at the onset of the carbapenem-resistant Enterobacteriaceae epidemic in New York City-author response.

J Antimicrob Chemother 2018 Dec 5. Epub 2018 Dec 5.

Division of Infectious Diseases, Department of Medicine, State University of New York Downstate, New York, NY, USA.

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December 2018
1 Read

Risk factors and molecular features of extended-spectrum beta-lactamase producing bacteria at southwest of Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1186-1194

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To explore the risk factors, the prevalence rate, and gene types of extended-spectrum beta-lactamase (ESBL)-producing bacteria as the causative agents of infection at King Abdulaziz Specialist Hospital (KAASH), Taif, Kingdom of Saudi Arabia. Methods: This was a retrospective study conducted during the period between February 2017 and January 2018. All samples obtained from the KAASH were analyzed. Read More

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December 2018
2 Reads

Zinc Blockade of SOS Response Inhibits Horizontal Transfer of Antibiotic Resistance Genes in Enteric Bacteria.

Front Cell Infect Microbiol 2018 21;8:410. Epub 2018 Nov 21.

Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States.

The SOS response is a conserved response to DNA damage that is found in Gram-negative and Gram-positive bacteria. When DNA damage is sustained and severe, activation of error-prone DNA polymerases can induce a higher mutation rate than is normally observed, which is called the SOS mutator phenotype or hypermutation. We previously showed that zinc blocked the hypermutation response induced by quinolone antibiotics and mitomycin C in and . Read More

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November 2018
1 Read

Distribution and drug resistance of pathogenic bacteria in ventilator-associated pneumonia at a local hospital of North-eastern China.

Infect Drug Resist 2018 13;11:2249-2255. Epub 2018 Nov 13.

Department of Emergency, Shengjing Hospital Affiliated to China Medical University, Heping District, Shenyang, Liaoning Province 110004, People's Republic of China,

Purpose: To study the distribution of pathogenic bacteria in ventilator-associated pneumonia (VAP), and epidemiological characteristics of extended-spectrum β lactamase (ESBL)-producing bacteria.

Patients And Methods: Lower respiratory tract secretions from 156 patients with mechanical ventilation were collected using a protective specimen brush (PSB), with quantitative bacterial culture carried out and antibiotic sensitivity measured. ESBLs produced by Gram-negative bacilli were detected using the double disk diffusion method and monitored by plasmid profiles. Read More

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November 2018

Inhibition of inflammasome activation by a clinical strain of Klebsiella pneumoniae impairs efferocytosis and leads to bacterial dissemination.

Cell Death Dis 2018 Dec 5;9(12):1182. Epub 2018 Dec 5.

Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University, Araraquara, São Paulo, Brazil.

Klebsiella pneumoniae is a Gram-negative bacterium responsible for severe cases of nosocomial pneumonia. During the infectious process, both neutrophils and monocytes migrate to the site of infection, where they carry out their effector functions and can be affected by different patterns of cell death. Our data show that clinical strains of K. Read More

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December 2018

A systematic review of the association between delayed appropriate therapy and mortality among patients hospitalized with infections due to Klebsiella pneumoniae or Escherichia coli: how long is too long?

BMC Infect Dis 2018 Dec 5;18(1):625. Epub 2018 Dec 5.

Meta Research, Evidera, Bethesda, MD, USA.

Background: Temporal relationships between the time to appropriate antibiotic therapy and outcomes are not well described.

Methods: A systematic literature review and meta-analysis was performed to examine this relationship in patients hospitalized with Klebsiella pneumoniae or Escherichia coli infections.

Results: Twenty identified studies contained data for patients who received delayed appropriate therapy (DAT) versus appropriate antibiotic therapy for these pathogens. Read More

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December 2018

Comment on: CG258 Klebsiella pneumoniae isolates without β-lactam resistance at the onset of the carbapenem-resistant Enterobacteriaceae epidemic in New York City.

J Antimicrob Chemother 2018 Nov 30. Epub 2018 Nov 30.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia.

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November 2018

Antibiotic resistance of Enterobacteriaceae causing urinary tract infections in elderly patients living in the community and in the nursing home: a retrospective observational study.

J Antimicrob Chemother 2018 Nov 30. Epub 2018 Nov 30.

Université de Lorraine, APEMAC, F-54000 Nancy, France.

Objectives: Although nursing homes are thought to be significant reservoirs of antibiotic-resistant bacteria, very few large population-based studies comparing antibiotic resistance prevalence in nursing homes and in the community have adjusted for patient characteristics. Our objective was to compare the prevalence of antibiotic resistance of Enterobacteriaceae cultured from urine samples of nursing home residents with that of community-dwelling adults, all aged 65 years or older.

Methods: This study analysed around 20 000 positive urine samples sent to a large laboratory in north-eastern France from 2014 to 2017, collected from individuals aged 65 years or older. Read More

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November 2018

Characterization of a multidrug-resistant Klebsiella pneumoniae ST607-K25 clone responsible for a nosocomial outbreak in a neonatal intensive care unit.

J Med Microbiol 2018 Dec 3. Epub 2018 Dec 3.

2​Microbiology Research Unit, AGIR -EA4294, Jules Verne University of Picardie, Amiens, France.

Purpose: Multidrug-resistant Klebsiella pneumoniae strains are regularly involved in hospital outbreaks. This study describes an ESBL-producing K. pneumoniae clone (ST607-K25) responsible for a nosocomial outbreak in a neonatal intensive care unit. Read More

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December 2018

Nasal septal abscess: a 10-year retrospective study.

Eur Arch Otorhinolaryngol 2018 Nov 30. Epub 2018 Nov 30.

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road Section 2, Taipei 114, Taiwan, ROC.

Objective: Nasal septal abscess is an uncommon condition but it can cause potentially life-threatening intracranial complications and cosmetic nasal deformity.

Methods: We analyzed ten years of cases to determine the optimal diagnostic and therapeutic modalities. A retrospective review of case notes from Tri-Service General Hospital archives was performed. Read More

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November 2018
3 Reads

Whole Genome Sequencing detects Inter-Facility Transmission of Carbapenem-resistant Klebsiella pneumoniae.

J Infect 2018 Nov 29. Epub 2018 Nov 29.

Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, 9331 Robert D. Snyder Road, Charlotte North Carolina, 28223, USA. Electronic address:

Objectives: To identify transmission patterns of Carbapenem-resistant Klebsiella pneumoniae infection during an outbreak at a large, tertiary care hospital and to detect whether the outbreak organisms spread to other facilities in the integrated healthcare network METHODS: We analyzed 71 K. pneumoniae whole genome sequences collected from clinical specimens before, during and after the outbreak and reviewed corresponding patient medical records. Sequence and patient data were used to model probable transmissions and assess factors associated with the outbreak. Read More

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November 2018

Endogenous endophthalmitis due to Klebsiella pneumoniae from an infected gallbladder.

Can J Ophthalmol 2018 Dec 16;53(6):e258-e260. Epub 2018 Mar 16.

University of Alberta, Edmonton, Alta. Electronic address:

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December 2018
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Hypervirulent Klebsiella pneumoniae: a new public health threat.

Expert Rev Anti Infect Ther 2018 Nov 30. Epub 2018 Nov 30.

a Departments of Medicine , University at Buffalo-State University of New York , Buffalo , NY , USA.

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November 2018

[Antimicrobial resistance changes of carbapenem-resistant strains isolated from children].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):907-914

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.

To investigate the prevalence and resistance changes of carbapenem-resistant (CRE) strains isolated from children patients of Chinese Bacterial Resistance Surveillance Network (CHINET) from 2005 to 2017. Antimicrobial susceptibility testing was carried out by disk diffusion method (KB method) and automated systems. Results were analyzed according to the Clinical and Laboratory Standards Institute (CLSI) 2017 edition standards. Read More

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December 2018
2 Reads

Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307.

J Antimicrob Chemother 2018 Dec 4. Epub 2018 Dec 4.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia.

Objectives: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes.

Methods: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). Read More

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December 2018

Prevalence, Antimicrobial Susceptibility Pattern, and Associated Factors of Urinary Tract Infections among Adult Diabetic Patients at Metu Karl Heinz Referral Hospital, Southwest Ethiopia.

Int J Microbiol 2018 1;2018:7591259. Epub 2018 Nov 1.

Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

Urinary tract infection causes considerable morbidity in diabetic patients and if complicated, can cause severe renal damage and life-threatening infections. The escalating antimicrobial resistance rate among bacteria over the past years is another concern in the treatment of urinary tract infections. This study investigated the prevalence, antimicrobial susceptibility pattern of the isolates and associated factors of urinary tract infection among adult diabetic patients attending Metu Karl Heinz Referral Hospital, Southwest Ethiopia. Read More

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November 2018
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Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.

Front Immunol 2018 20;9:2675. Epub 2018 Nov 20.

Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Epalinges, Switzerland.

Sirtuin 5 (SIRT5) is a member of the family of NAD-dependent lysine/histone deacetylases. SIRT5 resides mainly in the mitochondria where it catalyzes deacetylation, demalonylation, desuccinylation, and deglutarylation of lysine to regulate metabolic and oxidative stress response pathways. Pharmacologic inhibitors of SIRT5 are under development for oncologic conditions, but nothing is known about the impact of SIRT5 on antimicrobial innate immune defenses. Read More

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November 2018
2 Reads

A Pilot Study: Changes of Gut Microbiota in Post-surgery Colorectal Cancer Patients.

Front Microbiol 2018 20;9:2777. Epub 2018 Nov 20.

Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.

Colorectal cancer (CRC) is a growing health problem throughout the world. Strong evidences have supported that gut microbiota can influence tumorigenesis; however, little is known about what happens to gut microbiota following surgical resection. Here, we examined the changes of gut microbiota in CRC patients after the surgical resection. Read More

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November 2018

Heterologous expression of Thrombocidin-1 in Pichia pastoris: Evaluation of its antibacterial and antioxidant activity.

Microb Pathog 2018 Dec 1. Epub 2018 Dec 1.

Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Iran.

The antimicrobial peptide Thrombocidin-1 (TC-1) isolated from human blood that derived from NAP-2 by deleting of two amino acids from C-terminal region. In this study, a C-terminal 6 _ His tagged recombinant TC-1 was expressed as a secreted peptide in Pichia pastoris, for the first time. The recombinant P. Read More

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December 2018
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Metabolic regulation protects mice against Klebsiella pneumoniae lung infection.

Exp Lung Res 2018 Dec 4:1-10. Epub 2018 Dec 4.

b Department of Infectious Diseases , Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.

Purpose: Klebsiella pneumoniae-caused pneumonia is a risk factor for development of lung injury. However, the current clinical isolates of K. pneumoniae are mostly multidrug-resistance and thus must be addressed with new treatments. Read More

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December 2018
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[Bacteremia caused by Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae. A retrospective study of 7 years].

Rev Esp Quimioter 2018 Dec 4. Epub 2018 Dec 4.

María Inés Lespada. Unidad de Infectología, Hospital General de Agudos "Dr. Cosme Argerich". Pi y Margall 750, C1155AHD Ciudad Autónoma de Buenos Aires, Argentina.

Objective: Bacteremia caused by Klebsiella pneumoniae carbapenemase-producing strains (Kp-KPC) is associated with high mortality. The hypothesis of our work is that there was an increase in the levels of resistance to different antimicrobials in Kp-KPC isolated from bacteremia.

Methods: Retrospective and descriptive study in two periods: Period 1 (P1) 2010-2014 and period 2 (P2) 2015-2016. Read More

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December 2018
2 Reads

Emerging antimicrobial resistance among strains in bloodstream infections in Toronto, 2006-2016: a retrospective cohort study.

CMAJ Open 2018 Oct-Dec;6(4):E580-E586. Epub 2018 Dec 3.

Department of Microbiology (Mineau, Kozak, Kissoon, Paterson, Oppedisano, Douri, Gogan, Willey, McGeer, Poutanen), University Health Network/Sinai Health System, Toronto, Ont.; Centre intégré de santé et de services sociaux de Chaudière-Appalaches (Mineau), Sainte-Marie, Que.; Lawrence Park Collegiate Institute (Gogan); Departments of Laboratory Medicine and Pathobiology and of Medicine (McGeer, Poutanen), University of Toronto, Toronto, Ont.

Background: Enterobacteriaceae that produce extended-spectrum β-lactamase (ESBL) have emerged as a serious threat, with variable rates depending on geographic region. We determined the prevalence of ESBL-producing , , and in bloodstream infections in Toronto from 2006 through 2016.

Methods: All patients with , , and isolated from blood in a tertiary care microbiology laboratory in Toronto between 2006 and 2016 (1 isolate per species per patient per year) were included in this retrospective cohort study. Read More

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December 2018
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Crystalloid fluid administration was associated with outcomes in pediatric patients with severe sepsis or septic shock.

Medicine (Baltimore) 2018 Nov;97(48):e12663

Department of Pediatric General Surgery and Liver Transplantation.

Intravenous fluid prescription plays an important role in sepsis management, which may be associated with patient prognosis. The objective of the present study was to determine if the administration of crystalloid fluids is associated with clinical outcome for patients with severe sepsis and septic shock.The medical records of 79 patients with severe sepsis or septic shock at an academic tertiary care hospital between 2011 and 2016 were reviewed retrospectively. Read More

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November 2018

Antimicrobial-resistant pathogens in Canadian ICUs: results of the CANWARD 2007 to 2016 study.

J Antimicrob Chemother 2018 Nov 29. Epub 2018 Nov 29.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, R3E 0J9, Canada.

Objectives: To describe the microbiology and antimicrobial resistance patterns of cultured samples acquired from Canadian ICUs.

Methods: From 2007 to 2016, tertiary care centres from across Canada submitted 42 938 bacterial/fungal isolates as part of the CANWARD surveillance study. Of these, 8130 (18. Read More

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November 2018
3 Reads

In vitro evaluation of mercury (Hg) effects on biofilm formation by clinical and environmental isolates of Klebsiella pneumoniae.

Ecotoxicol Environ Saf 2018 Nov 27;169:669-677. Epub 2018 Nov 27.

Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Pernambuco, Brazil. Electronic address:

The increase in urbanization and industrialization has contributed to the contamination of different environments by means of xenobiotic compounds, such as heavy metals, causing changes in microbial communities. Among these metals, the Mercury (Hg) is one the most prevalent toxic metals for the environment The present study aimed to evaluate the effect of mercury on the formation of biofilm by environmental (collected from urban stream water) and clinical isolates of Klebsiella pneumoniae. In addition, antibiotic resistance, virulence factors, and genetic diversity were investigated. Read More

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November 2018
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Emergence of Enterobacteriaceae co-producing CTX-M-15, ArmA and PMQR in Poland.

Adv Clin Exp Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Bacteriology, National Institute of Public Health-National Institute of Hygiene, Warszawa, Poland.

Background: Plasmid-mediated extended-spectrum β-lactamases (ESBLs), 16S rRNA methylases and quinolone resistance mechanisms (PMQRs) are well-known agents conferring resistance to more than 1 antimicrobial in its group. The accumulation of these agents poses, therefore, a serious risk to public health.

Objectives: The objective of this study was to investigate the presence of common ß-lactamases and 16S rRNA methylases in Qnr-producing Enterobacteriaceae and their genetic relatedness. Read More

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November 2018
1 Read

Bacterial and Parasitic Assessment from Fingernails in Debre Markos, Northwest Ethiopia.

Can J Infect Dis Med Microbiol 2018 18;2018:6532014. Epub 2018 Oct 18.

Department of Medical Laboratory Science, College of Medical and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Background: Food handlers with untrimmed finger nails could contribute or serve as a vehicle for the transmission of food poisoning pathogens.

Objectives: This study was conducted to determine the prevalence of bacteria and intestinal parasites among food handlers and antibiotic susceptibility profile of the isolated bacteria in Debre Markos University, Ethiopia.

Materials And Methods: This laboratory-based cross-sectional study involved 220 food handlers working in food service establishments in Debre Markos University between 1st January 2015 to 31th June 2016. Read More

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October 2018
4 Reads

Resistance phenotype and clinical molecular epidemiology of carbapenem-resistant among pediatric patients in Shanghai.

Infect Drug Resist 2018 24;11:1935-1943. Epub 2018 Oct 24.

Department of Clinical Laboratory, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China,

Background: Carbapenem-resistant (CRKP) has caused wide global disseminations and serious clinical outcomes in pediatric patients, and the purpose of this study was to analyze drug resistance, molecular epidemiology, and clinical characteristics of CRKP from children in Shanghai, China.

Methods: A retrospective study was conducted from January 2016 to December 2017, and a total of 170 CRKP isolates were collected. Antimicrobial susceptibility was determined by the broth microdilution method. Read More

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October 2018

Pattern of antimicrobial resistance of Gram-negative bacilli in surgical site infections in in-patients and out-patients at an apex trauma Center: 2013-2016.

J Lab Physicians 2018 Oct-Dec;10(4):432-436

Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Antimicrobial resistance is an increasing problem worldwide especially among the surgical site infections (SSIs). SSI is becoming more serious due to hospital-acquired infections/nosocomial infections, which further leads to the overuse of broad-spectrum antibiotics. To investigate the antimicrobial resistance patterns among Gram-negative bacteria in SSI in in- and out-patients the present study was designed. Read More

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December 2018

Prevalence, etiology, and antibiotic resistance profiles of bacterial bloodstream infections in a tertiary care hospital in Northern India: A 4-year study.

J Lab Physicians 2018 Oct-Dec;10(4):426-431

Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Bloodstream infections (BSIs) can lead to life-threatening sepsis and are globally associated with high morbidity and mortality. Although BSIs require immediate antimicrobial treatment, their prevalence, etiology, and antimicrobial susceptibilities differ from one country to other. There is a dearth of such data from India. Read More

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December 2018
2 Reads

Prevalence of KPC and its occurrence with other beta-lactamases in .

J Lab Physicians 2018 Oct-Dec;10(4):387-391

Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

Background: () is an important nosocomial pathogen, and the emergence of multidrug resistance in these organisms limits the treatment options for serious infections caused by them. carbapenemase (KPC) is one of the clinically significant Class A beta-lactamases.

Aim And Objective: This study was aimed to detect the KPC and its coexistence with other beta-lactamases in . Read More

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December 2018
1 Read

Intraventricular tigecycline for the treatment of shunt infection: a case in pediatrics.

Authors:

J Neurosurg Pediatr 2018 Nov 1:1-4. Epub 2018 Nov 1.

Ventriculoperitoneal (VP) shunt infections are seen in 3%-17% of patients with VP shunts. These infections may cause severe morbidity and mortality. Staphylococci are the most common cause of CSF shunt-associated infections, although gram-negative bacteria (especially multidrug-resistant [MDR] and extensive drug-resistant [XDR] bacteria) also play an important role. Read More

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November 2018
1 Read

New ST in multidrug-resistant Klebsiella pneumoniae harboring bla encoding gene in Brazil.

Int J Infect Dis 2018 Nov 26. Epub 2018 Nov 26.

Departamento de Patologia, Análises Clínicas e Toxicológicas, Universidade Estadual de Londrina, Londrina, Paraná, Brazil. Electronic address:

Objectives: The aim of this study was to investigate the bla gene, the pathogenic potential and antimicrobial resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae isolated from patients admitted to the University Hospital of Londrina between January 2014 and March 2017.

Methods: bla and virulence genes were investigated using conventional PCR methods Antimicrobial susceptibility tests were performed the disk diffusion method according to the standards described in CLSI 2017. Clonal relationships the NDM-positive isolates were determined by ERIC-PCR and MLST. Read More

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November 2018
2 Reads

The coexistence of three bla genes on an IncF/IncR plasmid in ST11 Klebsiella pneumoniae.

J Glob Antimicrob Resist 2018 Nov 26. Epub 2018 Nov 26.

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China; Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China; Center for Pathogen Research, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: We found three copies of bla on a plasmid of a Klebsiella pneumoniae strain and report the findings here.

Methods: A carbapenem-resistant K. pneumoniae clinical strain, SCEC020002, was subjected to whole genome sequencing using both short-read Illumina X10 platform and long-read MinION sequencer. Read More

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November 2018
2 Reads

Impact of Ceftazidime Use on Susceptibility Patterns in the Neonatal Intensive Care Unit.

Pediatr Infect Dis J 2018 Nov 27. Epub 2018 Nov 27.

University of Oklahoma College of Medicine, Oklahoma City, Oklahoma.

Background: Ceftazidime use in the neonatal intensive care unit (NICU) has increased following a cefotaxime shortage. The impact of this change is unknown. The purpose was to assess the effect of increased ceftazidime use on susceptibilities of Gram-negative organisms in the NICU. Read More

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November 2018
3 Reads

Outbreak of Yersiniabactin-Producing Klebsiella pneumoniae in a Neonatal Intensive Care Unit.

Pediatr Infect Dis J 2018 Nov 27. Epub 2018 Nov 27.

Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care & Neuropediatrics, Medical University of Vienna, Vienna, Austria.

Background: The Gram-negative bacterium Klebsiella pneumoniae is a frequent pathogen causing outbreaks in neonatal intensive care units (NICUs). Some Enterobacteriaceae can acquire the ability to sequester iron from infected tissue by secretion of iron-chelating compounds such as yersiniabactin. Here we describe an outbreak and clinical management of infections due to a highly virulent yersiniabactin-producing, non-multiresistant Klebsiella pneumoniae strain in a NICU. Read More

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November 2018
3 Reads

Laboratory Diagnosis of Bacterial Vaginosis and Potential Pathogens Other Than Group B Streptococcus in Vaginal Swab of Pregnant Women in Dhaka Medical College Hospital.

Mymensingh Med J 2018 Oct;27(4):834-842

Dr Mst Naznin Tarana, Research Student, Department of Microbiology, Dhaka Medical College, Dhaka, Bangladesh; E-mail:

Pathogenic microorganisms are important cause of maternal and neonatal infections which are transmitted from colonized vagina of mother. The purpose of the present study was to detect the potential pathogens other than Group B Streptococcus in vaginal swab of pregnant women. This prospective cross sectional study was conducted from July 2013 to June 2014 at Dhaka Medical College Hospital, Dhaka, Bangladesh. Read More

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October 2018
1 Read

Induction of Biofilm Formation in ATCC 13884 by Several Drugs: The Possible Role of Modulation.

Antibiotics (Basel) 2018 Nov 28;7(4). Epub 2018 Nov 28.

Grupo de Química Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Calle 67 No. 53-10, Medellín 050010, Colombia.

Bacterial resistance is caused by several biochemical factors, the formation of biofilm being one of the main causes. This process is triggered by (), through the production of endogenous molecules, although other substances such as natural products can also do this. In this work, we aimed to determine whether some drugs are involved in the induction of biofilm formation in ATCC 13884, and thus, increase bacterial resistance. Read More

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November 2018
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Biochemical identification techniques and antibiotic susceptibility profile of lipolytic ambiental bacteria from effluents.

Braz J Biol 2018 Nov 23. Epub 2018 Nov 23.

Laboratório de Micologia e Bioprospecção, Departamento de Microbiologia e Parasitologia, Instituto de Biologia, Universidade Federal de Pelotas - UFPel, Av. Eliseu Maciel, IB Prédio 18, Sala 03, CEP 96160-000, Capão do Leão, RS, Brasil.

Different methodologies have been developed throughout the years to identify environmental microorganisms to improve bioremediation techniques, determine susceptibility profiles of bacteria in contaminated environments, and reduce the impact of microorganisms in ecosystems. Two methods of bacterial biochemical identification are compared and the susceptibility profile of bacteria, isolated from residential and industrial wastewater, is determined. Twenty-four bacteria were retrieved from the bacteria bank of the Environmental Microbiology Laboratory at the Institute of Biology (IB) of the Universidade Federal de Pelotas, Pelotas, Brazil. Read More

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November 2018

Bacteriological profile of intra-abdominal infections in a tertiary care hospital.

Iran J Microbiol 2018 Aug;10(4):208-214

Nizam's Institute of Medical Sciences Panjagutta, Hyderabad, Telangana, India.

Background And Objectives: Intra-abdominal infections (IAIs) include a wide spectrum of pathological conditions, ranging from uncomplicated appendicitis to fecal peritonitis .The resulting infections should be diagnosed early and treated based on the organism isolated and its susceptibility. In this study the bacteriological profile and antimicrobial resistance pattern of intra-abdominal infections was analyzed. Read More

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August 2018
2 Reads

Antimicrobial Resistance Profiles of Nosocomial Pathogens in Regional China: A Brief Report from Two Tertiary Hospitals in China.

Med Sci Monit 2018 Nov 28;24:8602-8607. Epub 2018 Nov 28.

Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China (mainland).

BACKGROUND Antimicrobial resistance of nosocomial pathogens has become a worldwide problem that leads to major healthcare and economic burdens. Regional antimicrobial resistance profiles are needed to inform selection of proper antimicrobial agents. MATERIAL AND METHODS In collaboration with the Hospital Infection Control Office at our hospitals, we analyzed the constitution of nosocomial pathogens and the corresponding drug-resistance profiles. Read More

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November 2018

Genomic traits of Klebsiella oxytoca DSM 29614, an uncommon metal-nanoparticle producer strain isolated from acid mine drainages.

BMC Microbiol 2018 Nov 27;18(1):198. Epub 2018 Nov 27.

Dipartimento di Scienze Molecolari e Nanosistemi, University Cà Foscari Venezia, Via Torino 155, 30172, Mestre, Venezia, Italy.

Background: Klebsiella oxytoca DSM 29614 - isolated from acid mine drainages - grows anaerobically using Fe(III)-citrate as sole carbon and energy source, unlike other enterobacteria and K. oxytoca clinical isolates. The DSM 29614 strain is multi metal resistant and produces metal nanoparticles that are embedded in its very peculiar capsular exopolysaccharide. Read More

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November 2018

[Analysis of distribution and drug resistance of pathogens from the wounds of 1 310 thermal burn patients].

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):802-808

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

To analyze the distribution and drug resistance of pathogens from the wounds of thermal burn patients, so as to provide reliable basis for the rational use of antibiotics and the effective control over nosocomial infection. Wound samples of 1 310 thermal burn patients admitted into our burn wards from January 2012 to December 2017 were collected and retrospectively analyzed. API bacteria identification panels and automatical bacteria identification equipment were used to identify pathogens. Read More

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November 2018
1 Read

[Preliminary study on resistance mechanism and virulence features in carbapenems-resistant from burn patients].

Authors:
Z Chen J Xiang

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):796-801

Department of Burns and Plastic Surgery, Ruijin Hospitals, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.

To investigate resistance mechanism and virulence features of carbapenems-resistant (CRKP) and to provide theoretical foundation for the prevention and control of nosocomial infections in burn wards as well as clinical therapy of CRKP. Strains of isolated from clinical samples of burn patients hospitalized in our unit from February to December 2016 were collected. The diameters of inhibition zone of imipemen or meropenem susceptibility disk of the above strains were≤22 mm. Read More

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November 2018
2 Reads

[Further understanding of infection of carbapenems-resistant among burn patients and the related strategies for antimicrobial treatment].

Authors:
J Xiang J N Huan

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):790-795

Department of Burns and Plastic Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.

The prevalence of carbapenems-resistant Klebsiella pneumoniae (CRKP ) in burn wards has become one of the most troublesome issues in current management of bacterial infections. It is necessary for us to reconsider the epidemiology, risk factors and clinical characteristics of CRKP infection as well as therapeutic options. Formulating the principles of antimicrobial therapy of CRKP infection and combined antibiotics therapy and implementing appropriate dosage regimens designed by pharmacokinetic and pharmacodynamic profiles will be of importance. Read More

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November 2018
4 Reads

Evaluation of procalcitonin accuracy for the distinction between Gram-negative and Gram-positive bacterial sepsis in burn patients.

J Burn Care Res 2018 Nov 14. Epub 2018 Nov 14.

Department of Emergency and Intensive Care Medicine, Centro Hospitalar São João, Porto, Portugal. Faculty of Medicine, University of Porto. Grupo de Infecção e Sépsis.

Background: Sepsis is the main cause of death in burns. Early institution of antimicrobial therapy is crucial to optimize outcomes but superfluous therapy increases adverse events, microbial resistance and costs. Blood cultures are the gold standard for diagnosis but can take 48-72 hours. Read More

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November 2018
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In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing .

Antimicrob Resist Infect Control 2018 21;7:142. Epub 2018 Nov 21.

1Institute of Antibiotics, Huashan Hospital, Fudan University, 12 M. Wulumuqi Rd, Shanghai, 200040 China.

Background: In recent years, the incidence of carbapenem-resistant (CRE) infections has increased rapidly. Since the CRE strain is usually resistant to most of antimicrobial agents, patients with this infection are often accompanied by a high mortality. Therefore, it instigates a severe challenge the clinical management of infection. Read More

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November 2018
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