18,211 results match your criteria Klebsiella Infections


Shifting Gears: The Future of Polymyxin Antibiotics.

Antibiotics (Basel) 2019 Apr 12;8(2). Epub 2019 Apr 12.

Department of Internal Medicine; Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

The manuscripts contained in this special edition of Antibiotics represent a current review of the polymyxins as well as highlights from the 3rd International Polymyxin Conference, which was held in Madrid, Spain, April 25 to 26, 2018. The role of the polymyxin antibiotics has evolved over time based on the availability of alternative agents. After high rates of nephrotoxicity caused the drug class to fall out of favor, polymyxins were once against utilized in the 21st century to combat drug-resistant pathogens. Read More

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http://dx.doi.org/10.3390/antibiotics8020042DOI Listing

Increasing burden of Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecium in hospital-acquired bloodstream infections (2000-2014): A national dynamic cohort study.

Infect Control Hosp Epidemiol 2019 Apr 23:1-5. Epub 2019 Apr 23.

Healthcare-Associated Infections and Antimicrobial Resistance, Public Health and Surveillance Department,Scientific Institute of Public Health,Brussels,Belgium.

The epidemiology of hospital-acquired bloodstream infections (HABSIs) based on the Belgian national surveillance program was analyzed (2000-2014). Our mixed-effects regression analysis identified increased rates of Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecium. HABSI incidence and resistance patterns should be further monitored because of their impact on proper empiric antibiotic therapy. Read More

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https://www.cambridge.org/core/product/identifier/S0899823X1
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http://dx.doi.org/10.1017/ice.2019.59DOI Listing
April 2019
1 Read

Integration of genomic and clinical data augments surveillance of healthcare-acquired infections.

Infect Control Hosp Epidemiol 2019 Apr 23:1-7. Epub 2019 Apr 23.

Department of Microbiology and Physiological Systems,University of Massachusetts Medical School,Worcester,Massachusetts.

Background: Determining infectious cross-transmission events in healthcare settings involves manual surveillance of case clusters by infection control personnel, followed by strain typing of clinical/environmental isolates suspected in said clusters. Recent advances in genomic sequencing and cloud computing now allow for the rapid molecular typing of infecting isolates.

Objective: To facilitate rapid recognition of transmission clusters, we aimed to assess infection control surveillance using whole-genome sequencing (WGS) of microbial pathogens to identify cross-transmission events for epidemiologic review. Read More

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http://dx.doi.org/10.1017/ice.2019.75DOI Listing

Draft genome sequence and analysis of strain NK-1 isolated from ureteral stent.

Data Brief 2019 Jun 3;24:103853. Epub 2019 Apr 3.

Department of Microbiology, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kremlyovskaya Str. 18, Kazan 420008, Russia.

is a facultative aerobic, gram-negative, rod-shaped bacterium capable of causing nosocomial infections, in particular catheter-associated urinary tract infections (CAUTIs). Data on the possible roles of uncommon pathogens such as in the pathogenesis of biofilm-associated infections such as CAUTIs have been already reported. Herein, we describe the draft genome sequence of strain NK-1 isolated from the surface of ureteral stent retrieved from a Russian female. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523409193020
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http://dx.doi.org/10.1016/j.dib.2019.103853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463764PMC
June 2019
1 Read

Isolation of phage lysins that effectively kill in mouse models of lung and skin infection.

Antimicrob Agents Chemother 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA.

Multi-drug resistance (MDR) is rapidly increasing in prevalence among isolates of the opportunistic pathogen , leaving few treatment options. Phage lysins are cell wall hydrolases that have a demonstrated therapeutic potential against Gram-positive pathogens, however the outer membrane of Gram-negative bacteria prevents most lysins from reaching the peptidoglycan, making them less effective as therapeutics. Nevertheless, a few lysins from gram-negative phage can penetrate the bacterial outer membrane, aided by an amphipathic tail found in the molecule's termini. Read More

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http://dx.doi.org/10.1128/AAC.00024-19DOI Listing

Genome sequence of a multidrug resistant Klebsiella pneumoniae ST78 with high colistin resistance isolated from a patient.

J Glob Antimicrob Resist 2019 Apr 18. Epub 2019 Apr 18.

Cholera and Biofilm Research Laboratory, Pathogen Biology Group, Rajiv Gandhi Centre for Biotechnology, Thiruvanathapuram, Kerala 695014, India. Electronic address:

Objectives: Multidrug resistantKlebsiella pneumoniae with colistin resistance have been considered as a major concern in healthcare settings. The present study aims to evaluate the genome wide distribution of antibiotic resistance genes in K. pneumoniae CRKP I with high colistin resistance isolated from a patient. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.04.008DOI Listing

Management of carbapenem resistant Enterobacteriaceae infections.

Clin Microbiol Infect 2019 Apr 17. Epub 2019 Apr 17.

Internal Medicine, University of Campania 'L. Vanvitelli' & Unit of Infectious and Transplant Medicine, AORN Ospedali dei Colli-Monaldi Hospital, Naples, Italy.

Background: Carbapenem resistance is defined as in vitro nonsusceptibility to any carbapenem and/or documented production of a carbapenemase. This feature has rapidly spread worldwide among clinical isolates of Enterobacteriaceae, mostly Klebsiella spp, and is associated with diverse molecular mechanisms. Carbapenem resistance is often associated with resistance to all traditional beta-lactams and other classes of antibiotics, denoting a typical example of extensively drug-resistant phenotype. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193018
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http://dx.doi.org/10.1016/j.cmi.2019.04.013DOI Listing
April 2019
1 Read

Effective Topical Delivery of H-AgNPs for Eradication of Klebsiella pneumoniae-Induced Burn Wound Infection.

AAPS PharmSciTech 2019 Apr 19;20(5):169. Epub 2019 Apr 19.

Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

The aim of the present study was to explore the therapeutic efficacy of microemulsion-based delivery of histidine-capped silver nanoparticles in eradicating Klebsiella pneumoniae-induced burn wound infection. The developed microemulsion was characterized on the basis of differential light scattering, phase separation, refractive index, and specific conductance. Emulgel was prepared and characterized on the basis of thixotropy, texture, differential scanning calorimetry, and release kinetics. Read More

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http://dx.doi.org/10.1208/s12249-019-1350-yDOI Listing

A comparative analysis of infection in patients with malignant cancer: A clinical pharmacist consultation study.

J Infect Public Health 2019 Apr 17. Epub 2019 Apr 17.

Department of Oncology, Peking University International Hospital, Beijing 102206, China. Electronic address:

Background: Infection analysisamongst malignant cancer patients remains elusive. The objective of this study is to investigate the characteristics of both infection and anti-infection treatments in patients group with malignant cancer.

Methods: We retrospectively studied the clinical data of 148 patients with malignant cancer and 171 benign patients enrolled in the pharmacist consultation from April 2015 to April 2017. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.021DOI Listing

Reversal of carbapenemase-producing Klebsiella pneumoniae epidemiology from blaKPC- to blaVIM-harbouring isolates in a Greek ICU after introduction of ceftazidime/avibactam.

J Antimicrob Chemother 2019 Apr 19. Epub 2019 Apr 19.

Department of Microbiology, School of Medicine, University of Patras, 26504, Rion-Patras, Greece.

Objectives: Our aim was to determine the epidemiology of bloodstream infections (BSIs) by carbapenemase-producing Klebsiella pneumoniae (CP-Kp) after the introduction of ceftazidime/avibactam in January 2018 among ICU patients.

Patients And Methods: All patients hospitalized at the ICU of the University General Hospital of Patras, Greece with CP-Kp BSI during 2015-18 were included. MICs of meropenem, fosfomycin, tigecycline and ceftazidime/avibactam (only for isolates from 2018) were determined by Etest, whereas for colistin, the broth microdilution method was applied. Read More

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http://dx.doi.org/10.1093/jac/dkz125DOI Listing

Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging ST101 Lineage.

Front Microbiol 2019 2;10:542. Epub 2019 Apr 2.

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.

The global dissemination of and carbapenemase (KPC) has been largely attributed to a few high-risk sequence types (STs) (ST258, ST11, ST512) associated with human disease. ST101 is an emerging clone that has been identified in different parts of the world with the potential to become a global, persistent public health threat. Recent research suggests the ST101 lineage is associated with an 11% increase in mortality rate in comparison to non-ST101 infections. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454207PMC

Antimicrobial consumption and bacterial resistance pattern in patients admitted in I.C.U at a tertiary care center.

J Infect Public Health 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesia, Lady Hardinge Medical College, New Delhi, India.

Background: Throughout the world multi drug resistant nosocomial infections are one of the leading causes of death and morbidity among hospitalized patients. Antimicrobial resistance [AMR] has become a major problem in treatment of such infections. High consumption of antimicrobials particularly in ICUs is often described as the most important factor leading to AMR. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.014DOI Listing

Phenotypic and Genotypic characterization of ESBLs, AmpC and Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli Isolates.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objectives: Drug resistance among gram-negative bacteria is a worldwide challenge. Due to the importance of drug-resistant Klebsiella pneumoniae and Escherichia coli strains in hospital-acquired infections, we aimed to determine the phenotypic and genotypic characteristics of ESBLs, AmpC and Carbapenemase-producing isolates, obtained from hospitalized patients in Tehran and Ilam, Iran.

Materials And Methods: In total, 90 isolates of K. Read More

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http://dx.doi.org/10.1159/000500311DOI Listing

In vitro study of antimicrobial activity on Klebsiella Pneumoniae biofilms in endotracheal tubes.

J Chemother 2019 Apr 16:1-7. Epub 2019 Apr 16.

a Intensive Care Unit, Hospital Universitario y Politécnico La Fe , Valencia , Spain.

Effective treatment approaches for biofilms in endotracheal tubes (ETTs) are lacking. In this study, we evaluated the in vitro effects of five antimicrobials against biofilms formed by Klebsiella pneumoniae in ETTs. K. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1601801DOI Listing
April 2019
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Selective and suppressive effects of antibiotics on donor and recipient bacterial strains in gut microbiota determine transmission efficiency of blaNDM-1-bearing plasmids.

J Antimicrob Chemother 2019 Apr 15. Epub 2019 Apr 15.

Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, P. R. China.

Objectives: To test whether antibiotics of different functional categories exhibit differential potential in promoting transmission of MDR-encoding plasmids among members of the gut microbiome.

Methods: Rats inoculated with blaNDM-1-bearing Klebsiella pneumoniae were subjected to treatment with different types of antibiotics. The structural changes in the gastrointestinal (GI) tract microbiome were determined by 16S rRNA sequencing and analysis. Read More

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http://dx.doi.org/10.1093/jac/dkz137DOI Listing

Dissemination of multiple carbapenem resistance genes in an in vitro gut model simulating the human colon.

J Antimicrob Chemother 2019 Apr 15. Epub 2019 Apr 15.

University of Leeds, Healthcare Associated Infection Research Group, Department of Microbiology, Old Medical School, Thoresby Place, Leeds, UK.

Background: Carbapenemase-producing Enterobacteriaceae (CPE) pose a major global health risk. Mobile genetic elements account for much of the increasing CPE burden.

Objectives: To investigate CPE colonization and the impact of antibiotic exposure on subsequent resistance gene dissemination within the gut microbiota using a model to simulate the human colon. Read More

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http://dx.doi.org/10.1093/jac/dkz106DOI Listing
April 2019
2 Reads

Nosocomial infections in surgical intensive care unit: A retrospective single-center study.

Int J Crit Illn Inj Sci 2019 Jan-Mar;9(1):16-20

Department of Anaesthesiology and Critical Care, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India.

Aims: This study aims to study the incidence, microbiological and antibiotic sensitivity and resistance profile and impact on intensive care units (ICUs) stay and mortality of nosocomial infections in patients admitted to surgical ICU of our hospital.

Methods: A retrospective analysis of all patients admitted, over the course of 1 year, in the surgical ICU was undertaken. All patients who developed nosocomial infections were included in the study. Read More

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http://www.ijciis.org/text.asp?2019/9/1/16/253764
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http://dx.doi.org/10.4103/IJCIIS.IJCIIS_57_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423928PMC
April 2019
3 Reads

Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review.

Front Microbiol 2019 1;10:539. Epub 2019 Apr 1.

Department of Microbiology, Savitribai Phule Pune University, Pune, India.

The acronym ESKAPE includes six nosocomial pathogens that exhibit multidrug resistance and virulence: , and spp. Persistent use of antibiotics has provoked the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) bacteria, which render even the most effective drugs ineffective. Extended spectrum β-lactamase (ESBL) and carbapenemase producing Gram negative bacteria have emerged as an important therapeutic challenge. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00539
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http://dx.doi.org/10.3389/fmicb.2019.00539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452778PMC
April 2019
1 Read

In vitro activity of cefepime-enmetazobactam against Gram-negative isolates collected from United States and European hospitals during 2014-2015.

Antimicrob Agents Chemother 2019 Apr 15. Epub 2019 Apr 15.

Allecra Therapeutics SAS, St-Louis, France

Enmetazobactam, formerly AAI101, is a novel penicillanic acid sulfone extended-spectrum β-lactamase inhibitor. The combination of enmetazobactam with cefepime has entered clinical trials to assess safety and efficacy in patients with complicated urinary tract infections. Here, the in vitro activity of cefepime-enmetazobactam was determined for 1,993 clinical isolates of Enterobacteriaceae and collected in the US and Europe during 2014 and 2015. Read More

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http://dx.doi.org/10.1128/AAC.00514-19DOI Listing

Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae.

Antimicrob Agents Chemother 2019 Apr 15. Epub 2019 Apr 15.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

As increasing numbers of colistin-resistant bacteria emerge, new therapies are urgently needed to treat infections caused by these pathogens. The discovery of new combination therapies is one important way to solve such problems. Herein, we report that the antitumor drug PFK-158 and its analogs PFK-015 and 3PO can exert synergistic effects with colistin against colistin-resistant Enterobacteriaceae, including positive or high-level colistin resistant (HLCR) isolates, as shown by a checkerboard assay. Read More

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http://dx.doi.org/10.1128/AAC.00271-19DOI Listing

High prevalence of extended-spectrum beta-lactamase-producing Gram-negative pathogens from patients attending Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Amhara region.

PLoS One 2019 15;14(4):e0215177. Epub 2019 Apr 15.

Department of Medical Microbiology, School of Biomedical and laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Infections caused by extended-spectrum beta-lactamases (ESBL) producing Gram-negative bacteria has emerge as a global threat in clinical practices. The treat is more serious in developing countries due to inappropriate use, poor adherence, use of counterfeit, sub-standard antibiotics and poor infection control practices. Data on ESBL producing Gram-negative bacteria are limited in developing countries including Ethiopia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215177PLOS
April 2019
3.234 Impact Factor

Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae.

PLoS Genet 2019 Apr 15;15(4):e1008114. Epub 2019 Apr 15.

Department of Infectious Diseases, Monash University, Melbourne, Victoria, Australia.

Klebsiella pneumoniae has emerged as an important cause of two distinct public health threats: multi-drug resistant (MDR) healthcare-associated infections and drug susceptible community-acquired invasive infections. These pathotypes are generally associated with two distinct subsets of K. pneumoniae lineages or 'clones' that are distinguished by the presence of acquired resistance genes and several key virulence loci. Read More

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http://dx.plos.org/10.1371/journal.pgen.1008114
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http://dx.doi.org/10.1371/journal.pgen.1008114DOI Listing
April 2019
5 Reads

Uropathogens and their antimicrobial resistance patterns: Relationship with urinary tract infections.

Int J Health Sci (Qassim) 2019 Mar-Apr;13(2):48-55

Department of Pathology and Laboratory Medicine, College of Medicine, Qassim University, Saudi Arabia.

Objectives: This study was performed to determine the prevalence of uropathogens causing urinary tract infections (UTIs) and to determine their pattern of antimicrobial resistance.

Methods: This study was conducted on 273 urine samples collected from outpatient departments (OPDs) of Qassim University affiliated hospitals. Fully automated VITEK 2 compact system was used in the identification and antimicrobial susceptibility testing of causative microorganisms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436442PMC

1,4-Naphthoquinone Analogues: Potent Antibacterial Agents and Mode of Action Evaluation.

Molecules 2019 Apr 11;24(7). Epub 2019 Apr 11.

Department of Life Science, Department of Energy Storage/Conversion Engineering of Graduate School, and Hydrogen and Fuel Cell Research Center, Chonbuk National University, Jeollabuk-do 54896, Korea.

1,4-Naphthoquinones have antibacterial activity and are a promising new class of compound that can be used to treat bacterial infections. The goal was to improve effective antibacterial agents; therefore, we synthesized a new class of naphthoquinone hybrids, which contain phenylamino-phenylthio moieties as significant counterparts. Compound was modified as a substituted aryl amide moiety, which enhanced the antibacterial activity of earlier compounds and . Read More

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https://www.mdpi.com/1420-3049/24/7/1437
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http://dx.doi.org/10.3390/molecules24071437DOI Listing
April 2019
1 Read

Clinical Prediction Score for Community-Onset Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-Producing and Species.

J Korean Med Sci 2019 Apr 15;34(14):e116. Epub 2019 Apr 15.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: This study aimed to identify the predictors and build a prediction score for community-onset bloodstream infections (CO-BSIs) caused by extended-spectrum beta-lactamase (ESBL)-producing and species.

Methods: All CO-BSIs caused by and species from 2012 to 2015 were grouped into derivation (BSIs from 2012 to 2014) and validation (BSIs in 2015) cohorts. A prediction score was built using the coefficients of the multivariate logistic regression model from the derivation cohort. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460111PMC

Shifting trends and age distribution of ESKAPEEc resistance in bloodstream infection, Southwest China, 2012-2017.

Antimicrob Resist Infect Control 2019 29;8:61. Epub 2019 Mar 29.

1Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Yuzhong District, Chongqing, 400016 People's Republic of China.

Background: ESKAPEEc contribute to a majority of bloodstream infections (BSIs) and their antibiogram have changed overtime, while data concerning about these alterations are lacking in China. Added that a paucity of studies referred to ESKAPEEc in pediatric BSIs, our study aimed to demonstrate the longitudinal alterations of ESKAPEEc distribution and antibiogram in adult and pediatric BSIs in Southwest China.

Methods: A multicenter retrospective surveillance study was launched from 2012 to 2017. Read More

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http://dx.doi.org/10.1186/s13756-019-0499-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441235PMC
March 2019
1 Read

Molecular characterization of class 1, 2 and 3 integrons in clinical multi-drug resistant isolates.

Antimicrob Resist Infect Control 2019 29;8:59. Epub 2019 Mar 29.

3Evidence-based Phytotherapy & Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Background: The aim of this study was to characterize class 1,2 and 3 integrons in clinical MDR isolates in Kashan, Iran.

Methods: One hundred-eighty one were recovered from clinical specimens during November 2013 to October 2014. Antimicrobial susceptibility patterns were determined by disk diffusion method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines for detection of MDR strains. Read More

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http://dx.doi.org/10.1186/s13756-019-0509-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440154PMC

Two Component Regulatory Systems and Antibiotic Resistance in Gram-Negative Pathogens.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Department of Oral Biology, Rady Faculty of Health Sciences, University of Manitoba, 780 Bannatyne Ave, Winnipeg, MB R3E 0J9, Canada.

Gram-negative pathogens such as , , and are the leading cause of nosocomial infections throughout the world. One commonality shared among these pathogens is their ubiquitous presence, robust host-colonization and most importantly, resistance to antibiotics. A significant number of two-component systems (TCSs) exist in these pathogens, which are involved in regulation of gene expression in response to environmental signals such as antibiotic exposure. Read More

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https://www.mdpi.com/1422-0067/20/7/1781
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http://dx.doi.org/10.3390/ijms20071781DOI Listing
April 2019
2 Reads

Polymyxins: To Combine or Not to Combine?

Antibiotics (Basel) 2019 Apr 10;8(2). Epub 2019 Apr 10.

Medicine Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA.

Polymyxins have been a mainstay for the treatment of extensively drug resistant (XDR) Gram-negative bacteria for the past two decades. Many questions regarding the clinical use of polymyxins have been answered, but whether the administration of polymyxins in combination with other antibiotics leads to better outcomes remains unknown. This review discusses the limitations of observational studies that suggest a benefit of combinations of colistin and carbapenems to treat infections caused by carbapenem-resistant Enterobacteriaceae (CRE), especially carbapenemase (KPC)-producing , and summarizes the results of randomized controlled trials in which treatment with colistin in combination with meropenem or rifampin does not lead to better clinical outcomes than colisitn monotherapy in infections caused by carbapenem-resistant (CRAB). Read More

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http://dx.doi.org/10.3390/antibiotics8020038DOI Listing
April 2019
1 Read

Plazomicin Is Active Against Metallo-β-Lactamase-Producing Enterobacteriaceae.

Open Forum Infect Dis 2019 Apr 12;6(4):ofz123. Epub 2019 Mar 12.

Department of Clinical Microbiology, Achaogen, Inc., South San Francisco, California.

Plazomicin is an aminoglycoside that was approved in June 2018 by the US Food and Drug Administration for the treatment of complicated urinary tract infections, including pyelonephritis, due to , , , and . Plazomicin was engineered to overcome the most common aminoglycoside resistance mechanism, inactivation by aminoglycoside-modifying enzymes, but is not active against the less common 16S ribosomal RNA methyltransferases (16S-RMTase), which confer target site modification. As an aminoglycoside, plazomicin maintains activity against Enterobacteriaceae that express resistance mechanisms to other antibiotic classes, including metallo-β-lactamases. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofz12
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http://dx.doi.org/10.1093/ofid/ofz123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446133PMC
April 2019
2 Reads

Ceftolozane/Tazobactam Susceptibility Testing in Extended-Spectrum Betalactamase- and Carbapenemase-Producing Gram-Negative Bacteria of Various Clonal Lineages.

Eur J Microbiol Immunol (Bp) 2019 Mar 8;9(1):1-4. Epub 2019 Feb 8.

Faculty of Health, Center for Clinical and Translational Research, Institute of Medical Laboratory Diagnostics, HELIOS University Clinic Wuppertal, Witten/Herdecke University, Witten, Germany.

Nowadays, multidrug-resistant bacteria are considered as an increasing serious threat to public health worldwide. Global and local surveillance data are helpful in the application of the most efficient antimicrobial agent in bacterial infections. In the current study, we aimed to analyze the activity of the previously cleared agent ceftolozane/ tazobactam (C/T) in African and European multidrug-resistant Gram-negative bacteria. Read More

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https://www.akademiai.com/doi/10.1556/1886.2019.00001
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http://dx.doi.org/10.1556/1886.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444803PMC
March 2019
2 Reads

Osteomyelitis Caused by Carbapenemase-Producing Klebsiella Pneumoniae: A Diagnosis to Consider in Patients with Hematologic Malignancies and Stem Cell Transplant Recipients.

Am J Case Rep 2019 Apr 9;20:482-488. Epub 2019 Apr 9.

Department of Hematology and Bone Marrow Transplantation, Hospital de Santa Maria, CHLN - EPE, Lisboa, Portugal.

BACKGROUND Osteomyelitis (OM) due to carbapenemase-producing Klebsiella pneumoniae (CPKp) is a very rare but severe condition, particularly among patients with hematologic malignancies and stem cell transplant recipients, who are especially at risk of developing nosocomial infections caused by this bacterium. CASE REPORT We describe 2 cases of acute and chronic OM by CPKp in adults with hematologic disorders. Patient 1, with acute lymphoblastic leukemia, developed bacteremia due to multidrug CPKp after induction chemotherapy. Read More

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http://dx.doi.org/10.12659/AJCR.909965DOI Listing
April 2019
1 Read

Investigation of the susceptibility trends in Japan to fluoroquinolones and other antimicrobial agents in a nationwide collection of clinical isolates: A longitudinal analysis from 1994 to 2016.

J Infect Chemother 2019 Apr 3. Epub 2019 Apr 3.

Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Japan.

The susceptibilities of clinical isolates to fluoroquinolones and other antimicrobial agents were surveyed to obtain an accurate understanding of trends in incidence and antimicrobial resistance. The samples were collected from across Japan, biennially or triennially, between 1994 and 2016 and a defined level of resistance to fluoroquinolone was determined. Streptococcus pneumoniae, Streptococcus pyogenes and Haemophilus influenzae exhibited stable and high rates of susceptibility to fluoroquinolones over the period examined. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.03.008DOI Listing
April 2019
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Proteome profiling of carbapenem-resistant K. pneumoniae clinical isolate (NDM-4): Exploring the mechanism of resistance and potential drug targets.

J Proteomics 2019 May 3;200:102-110. Epub 2019 Apr 3.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India. Electronic address:

The emergence of carbapenem resistance has become a major problem worldwide. This has made treatment of K. pneumoniae infections a difficult task. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.04.003DOI Listing
May 2019
4 Reads
3.888 Impact Factor

Therapeutic Characterization and Efficacy of Bacteriophage Cocktails Infecting , , and Species.

Front Microbiol 2019 21;10:574. Epub 2019 Mar 21.

Antibiotic Resistance and Phage Therapy Laboratory, Department of Biomedical Sciences, School of Bioscience and Technology, Vellore Institute of Technology, Vellore, India.

Infections due to antibiotic resistant bacteria are increasing globally and this needs immediate attention. Bacteriophages are considered an effective alternative for the treatment of bacterial infections. The aim of this study was to isolate and characterize the bacteriophages that infect , , and species. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00574
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http://dx.doi.org/10.3389/fmicb.2019.00574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437105PMC
March 2019
10 Reads
3.941 Impact Factor

Evidence of sharing between healthy companion animals and co-habiting humans.

J Clin Microbiol 2019 Apr 3. Epub 2019 Apr 3.

Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal

This study aimed to characterize the fecal colonization and sharing of between companion animals and humans living in close contact.Fecal samples were collected from 50 healthy participants (24 humans, 18 dogs and 8 cats) belonging to 18 households. Samples were plated onto MacConkey agar plates (MCK) with and without cefotaxime or meropenem supplementation. Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.01537-18
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http://dx.doi.org/10.1128/JCM.01537-18DOI Listing
April 2019
3 Reads

Prevalence of cases of amebic liver abscess in a tertiary care centre in India: A study on risk factors, associated microflora and strain variation of Entamoeba histolytica.

PLoS One 2019 3;14(4):e0214880. Epub 2019 Apr 3.

Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., India.

Background: Amebiasis, caused by Entamoeba histolytica (E. histolytica), is a significant cause of morbidity and mortality in developing countries. Mortality due to amebiasis is mostly by extra intestinal infections, amebic liver abscess being the most common one. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214880PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447230PMC
April 2019
3 Reads

Assessment of device-associated infection rates in teaching hospitals in Islamic Republic of Iran.

East Mediterr Health J 2019 Mar 19;25(2):90-97. Epub 2019 Mar 19.

Department of Nursing, Sina Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

Background: Surveillance of health care-associated infections (HCAIs) is an integral part of infection control programmes, especially in intensive care units (ICUs). Device-associated infections (DAIs) are a major threat to patient safety.

Aim: To measure DAI rates in ICUs. Read More

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http://dx.doi.org/10.26719/emhj.18.015DOI Listing
March 2019
2 Reads

Evaluation of antimicrobial prophylaxis use and rate of surgical site infection in surgical ward of Wachemo University Nigist Eleni Mohammed Memorial Hospital, Southern Ethiopia: prospective cohort study.

BMC Infect Dis 2019 Apr 2;19(1):298. Epub 2019 Apr 2.

Ethiopian Biotechnology Institute, Addis Ababa, Ethiopia.

Background: Surgical site infection (SSI) is the foremost infection in the overall patient population, affecting up to 66% of operated patients and with a frequency up to nine times more than in developed countries. This study aimed to determine the rate, associated factors of surgical site infection, and identification of causative agents and their antimicrobial susceptibility in surgical ward of Wachemo University Nigist Eleni Mohamed Memorial Hospital (WUNEMMH), Southern Ethiopia.

Method: Prospective cohort study involving 255 patients who underwent surgical procedure in WUNEMMH from January 1 to September 1, 2017. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3895-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446332PMC
April 2019
2 Reads

Rapid phenotypic evolution in multidrug-resistant Klebsiella pneumoniae hospital outbreak strains.

Microb Genom 2019 Apr 2. Epub 2019 Apr 2.

2​Department of Clinical Laboratory, Peking University People's Hospital, Beijing, 100044, PR China.

Carbapenem-resistant Klebsiella pneumoniae (CRKP) increasingly cause high-mortality outbreaks in hospital settings globally. Following a patient fatality at a hospital in Beijing due to a blaKPC-2-positive CRKP infection, close monitoring was put in place over the course of 14 months to characterize all blaKPC-2-positive CRKP in circulation in the hospital. Whole genome sequences were generated for 100 isolates from blaKPC-2-positive isolates from infected patients, carriers and the hospital environment. Read More

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http://dx.doi.org/10.1099/mgen.0.000263DOI Listing
April 2019
3 Reads

Ultrafast Parallelized Microfluidic Platform for Antimicrobial Susceptibility Testing of Gram Positive and Negative Bacteria.

Anal Chem 2019 Apr 15. Epub 2019 Apr 15.

Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences , Northeastern University , 140 The Fenway , Boston , Massachusetts 02115 , United States.

Antimicrobial susceptibility testing (AST) is an essential diagnostic procedure to determine the correct course of treatment for various types of pathogen infections. Patients are treated with broad spectrum antibiotics until AST results become available, which has contributed to the emergence of multidrug resistant bacteria worldwide. Conventional AST methods require 16-24 h to assess sensitivity of the bacteria to a given drug and establish its minimum inhibitory concentration (MIC). Read More

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http://dx.doi.org/10.1021/acs.analchem.9b00939DOI Listing

Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review.

Clin Exp Pharmacol Physiol 2019 Apr 1. Epub 2019 Apr 1.

Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.

Urinary tract infection (UTI) is one of the most severe public health problem affecting both sexes but females are more susceptible due to the differences in urogenital and reproductive anatomy, physiology and lifestyle. As in UTI, different parts of the urinary tract are affected and morbidity due to UTI is more common in women of all ages and older men. Due to multi-drug resistant strains and high recurrence rate, UTI has become a major socioeconomic burden. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
Publisher Site
http://dx.doi.org/10.1111/1440-1681.13092DOI Listing
April 2019
9 Reads

Klebsiella Pneumoniae Visceral Organ Abscesses - Clinical Characteristics.

Ann Acad Med Singapore 2019 Feb;48(2):48-54

Division of Infectious Diseases, Changi General Hospital, Singapore.

Introduction: In recent years, () has emerged as the predominant cause of pyogenic liver abscess in Asia. - as the causative microorganism in other visceral organ abscesses-is less described. In this study, we seeked to describe the clinical characteristics of visceral organ abscesses in our institution and evaluated the prescription practices of physicians with regard to antibiotic therapy. Read More

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February 2019
3 Reads

Faecal microbiota transplantation for the decolonisation of antibiotic-resistant bacteria in the gut: a systematic review and meta-analysis.

Authors:
Vera Tavoukjian

J Hosp Infect 2019 Mar 26. Epub 2019 Mar 26.

Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, James Clerk Maxwell Building, 57 Waterloo Road, London SE1 8WA, United Kingdom. Electronic address:

Background: Antibiotic resistance is a growing global problem associated with increased morbidity and mortality, and presents a significant financial and economic burden on healthcare. FMT has been proven effective for curing recurrent Clostridium difficile infections, however no systematic review to date has addressed its effectiveness for decolonisation of antibiotic-resistant bacteria from the gut.

Aim: To answer the following research question: Does faecal microbiota transplantation decolonise antibiotic-resistant bacteria from the gut of colonised adults?

Methods: A systematic review was performed by undertaking a comprehensive search on MEDLINE, Embase, CENTRAL, PubMed and CINAHL databases for evidence up till May 2018. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.03.010DOI Listing

Innovations in Worksite Diagnosis of Urinary Tract Infections and the Occupational Health Nurse.

Workplace Health Saf 2019 Mar 29:2165079919834310. Epub 2019 Mar 29.

2 GeneCapture, Inc.

Occupational health nurses play a key role in evaluating innovative technologies that can aid in providing safe and rapid care and reduce lost work time. A nurse-led employee health clinic participated in a validation study of a novel pathogen detection technique developed by GeneCapture, Inc. Their proposed portable urinary tract infection (UTI) in vitro diagnostic test was challenged with discarded, deidentified urine samples from patients presenting with typical UTI symptoms collected at two university clinics and two multiphysician practices. Read More

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http://dx.doi.org/10.1177/2165079919834310DOI Listing

Cefquinome-Loaded Microsphere Formulations in Protection against Pneumonia with Klebsiella pneumonia Infection and Inflammatory Response in Rats.

Pharm Res 2019 Mar 28;36(5):74. Epub 2019 Mar 28.

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China.

Purpose: This study aimed to compare in vivo activity between cefquinome (CEQ)-loaded poly lactic-co-glycolic acid (PLGA) microspheres (CEQ-PLGA-MS) and CEQ injection (CEQ-INJ) against Klebsiella pneumonia in a rat lung infection model.

Methods: Forty-eight rats were divided into control group (sham operated without infection and drug treatment), Klebsiella pneumonia model group (KPD + Saline), CEQ-PLGA-MS and CEQ-INJ therapy groups (KPD + CEQ-PLGA-MS and KPD + INJ, respectively). In the KPD + Saline group, rats were infected with Klebsiella pneumonia ATCC 10031. Read More

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http://dx.doi.org/10.1007/s11095-019-2614-7DOI Listing
March 2019
3 Reads

Avibactam Sensitizes Carbapenem-Resistant NDM-1-Producing Klebsiella pneumoniae to Innate Immune Clearance.

J Infect Dis 2019 Mar 29. Epub 2019 Mar 29.

Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, CA, USA.

Infections caused by New Delhi metallo-β-lactamases (NDM)-producing strains of multidrug-resistant (MDR) Klebsiella pneumoniae (KP) are a global public health threat lacking reliable therapies. NDM is impervious to all existing β-lactamase inhibitor (BLI) drugs, including the non-β-lactam structure BLI, avibactam (AVI). Though lacking direct activity against NDM enzymes, AVI can interact with penicillin-binding protein 2 in a manner that may influence cell wall dynamics. Read More

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http://dx.doi.org/10.1093/infdis/jiz128DOI Listing

Comparison of the effectiveness of dipping agents on bacteria causing mastitis in cattle.

Ann Agric Environ Med 2019 Mar 21;26(1):39-45. Epub 2018 Feb 21.

Department of Microbiology, Nicolaus Copernicus University, Toruń, Poland; Collegium Medicum of L. Rydygier, Bydgoszcz, Poland.

Introduction: Mastitis may result in physical, chemical and microbiological changes in milk and pathological lesions in the glandular tissue. Milk derived from cows with mastitis may become a cause of infections in humansw and animals.

Objectives: The aim of this study was to assess the effectiveness of selected dipping agents in the inactivation of several bacteria that may cause mastitis in cattle. Read More

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http://dx.doi.org/10.26444/aaem/82626DOI Listing

OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs.

mSphere 2019 03 27;4(2). Epub 2019 Mar 27.

Department of Pharmacy, UiT-The Arctic University of Norway, Tromsø, Norway

Infections due to carbapenemase-producing Gram-negative pathogens are associated with limited treatment options and consequently lead to increased mortality and morbidity. In response, combinations of existing β-lactams and novel β-lactamase inhibitors, such as ceftazidime-avibactam (CAZ-AVI), have been developed as alternative treatment options. To understand the development of resistance and evolutionary trajectories under CAZ-AVI exposure, we studied the effects of ceftazidime (CAZ) and CAZ-AVI on the carbapenemase OXA-48 and the epidemic OXA-48 plasmid in Exposure of CAZ and CAZ-AVI resulted in single (P68A) and double (P68A,Y211S) amino acid substitutions in OXA-48, respectively. Read More

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http://dx.doi.org/10.1128/mSphere.00024-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437269PMC
March 2019
1 Read