17,962 results match your criteria Klebsiella Infections


Convergence of virulence and MDR in a single plasmid vector in MDR Klebsiella pneumoniae ST15.

J Antimicrob Chemother 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Microbiology, Stavanger University Hospital, Stavanger, Norway.

Background: MDR and hypervirulence (hv) are typically observed in separate Klebsiella pneumoniae populations. However, convergent strains with both properties have been documented and potentially pose a high risk to public health in the form of invasive infections with limited treatment options.

Objectives: Our aim was to characterize the genetic determinants of virulence and antimicrobial resistance (AMR) in two ESBL-producing K. Read More

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http://dx.doi.org/10.1093/jac/dkz028DOI Listing
February 2019

Activity of ceftolozane-tazobactam against Pseudomonas aeruginosa and Enterobacterales isolates recovered in Intensive Care Units in Spain: The SUPERIOR multicentre study.

Int J Antimicrob Agents 2019 Feb 12. Epub 2019 Feb 12.

Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain. Electronic address:

Patients in intensive care units (ICUs) present a high risk of developing an infection caused by multi-drug resistant (MDR) bacteria. Consequently, new antimicrobials and combinations are needed. We evaluated the activity of ceftolozane-tazobactam against Enterobacterales (n=400) and Pseudomonas aeruginosa (n=80) isolates collected from patients in Spanish intensive care units (ICUs) with complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI). Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.02.004DOI Listing
February 2019

Antibiotic resistance: Microbiological profile of urinary tract infections in Mexico.

Cir Cir 2019 ;87(2):176-182

Departamento de Inmunología, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.

Objective: The objective of this study was to describe the prevalence, microbiological profile, bacterial resistance, and the sensitivity to antibiotics of microorganisms causing urinary tract infection (UTI) at a single-site tertiary referral hospital in the western region of Mexico.

Methods: A total of 5895 culture samples processed at the microbiology laboratory from August 1, 2014, to July 31, 2015, were analyzed.

Results: A total of 5895 samples for urine cultures (UC) were collected, of which 3363 were taken in women (57. Read More

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http://dx.doi.org/10.24875/CIRU.18000494DOI Listing
January 2019

In vitro and in silico investigation of Caprylic acid effect on Multi Drug Resistant (MDR) Klebsiella pneumoniae biofilm.

J Biomol Struct Dyn 2019 Feb 15:1-12. Epub 2019 Feb 15.

c Senior Assistant Professor, Centre for Research in Infectious diseases (CRID), School of Chemical and Biotechnology (SCBT) , SASTRA Deemed University , Tirumalaisamudram, Thanjavur , 613401 , Tamil Nadu , India.

Catheters are highly prone to bacterial colonization during catheterization. Catheter-associated urinary tract infections caused by Klebsiella pneumoniae are significantly associated with high morbidity. Klebsiella pneumoniae is the prominent cause of infections in individuals with indwelling urinary catheters. Read More

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http://dx.doi.org/10.1080/07391102.2019.1581087DOI Listing
February 2019

Molecular characterization of multidrug-resistant Klebsiella pneumoniae belonging to CC258 isolated from outpatients with urinary tract infection in Brazil.

J Glob Antimicrob Resist 2019 Feb 11. Epub 2019 Feb 11.

Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil; School of Dentistry, University of Ribeirão Preto, Ribeirão Preto, SP, Brazil. Electronic address:

Objectives: The present study aimed to characterize 48 Klebsiella pneumoniae isolated from outpatients with urinary tract infections (UTIs) in the micro-region of Ribeirão Preto, located in the Southeastern of Brazil.

Methods: Thee isolates were identified by conventional biochemical and phenotypic tests and confirmed as K. pneumoniae using MALDI-TOF VITEK MS. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.01.025DOI Listing
February 2019

Monitoring the antimicrobial susceptibility of Gram-negative organisms involved in intraabdominal and urinary tract infections recovered during the SMART study (Spain, 2016 and 2017).

Rev Esp Quimioter 2019 Feb 13. Epub 2019 Feb 13.

Rafael Cantón. Servicio de Microbiología. Hospital Universitario Ramón y Cajal. Carretera de Colmenar Km 9,1. 28034 Madrid. Spain.

Objective: Continuous antimicrobial resistance surveillance is recommended by Public Health authorities. We up-dated data from the SMART (Study for Monitoring Antimicrobial Resistance Trends) surveillance study in Spain.

Methods: The antimicrobial susceptibility data and extended-spectrum beta-lactamase (ESBL) production in isolates recovered from intra-abdominal (IAI) (n=1,429) and urinary tract (UTI) (n=937) infections during the 2016- 2017 SMART study in 10 Spanish hospitals were analysed. Read More

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February 2019

Hemoptysis in the Immunocompromised Patient: Do Not Forget Strongyloidiasis.

Trop Med Infect Dis 2019 Feb 12;4(1). Epub 2019 Feb 12.

Department of Medicine, Division of Infectious Diseases, University of Texas Health, San Antonio, TX 78229, USA.

Strongyloidiasis, due to infection with the nematode , affects millions of people in the tropics and subtropics. has a unique auto-infective lifecycle such that it can persist in the human host for decades. In immunosuppressed patients, especially those on corticosteroids, potentially fatal disseminated strongyloidiasis can occur, often with concurrent secondary infections. Read More

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http://dx.doi.org/10.3390/tropicalmed4010035DOI Listing
February 2019

Epidemiology and risk factors for multi-drug resistant hospital-acquired urinary tract infection in patients with liver cirrhosis: single center experience in Serbia.

BMC Infect Dis 2019 Feb 12;19(1):141. Epub 2019 Feb 12.

Department of Anesthesiology, Clinical Center of Serbia, Belgrade, Serbia.

Background: Cirrhosis-associated immune dysfunction syndrome (CAIDS) has been identified in patients with liver cirrhosis (LC), predisposing them to a wide variety of infections. In patients with LC, healthcare-associated infections involving multi-drug resistant (MDR) bacteria have increased significantly over the last decades. Among them, hospital-acquired urinary tract infections (HA-UTI) are the most common. Read More

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http://dx.doi.org/10.1186/s12879-019-3761-5DOI Listing
February 2019

Epidemiology and risk factors for nosocomial infection in the respiratory intensive care unit of a teaching hospital in China: A prospective surveillance during 2013 and 2015.

BMC Infect Dis 2019 Feb 12;19(1):145. Epub 2019 Feb 12.

Department of Respiratory Intensive Care Unit of The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.

Background: To determine the epidemiology and risk factors for nosocomial infection (NI) in the Respiratory Intensive Care Unit (RICU) of a teaching hospital in Northwest China.

Methods: An observational, prospective surveillance was conducted in the RICU from 2013 to 2015. The overall infection rate, distribution of infection sites, device-associated infections and pathogen in the RICU were investigated. Read More

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http://dx.doi.org/10.1186/s12879-019-3772-2DOI Listing
February 2019
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Host and pathogen factors in Klebsiella pneumoniae upper urinary tract infections in renal transplant patients.

J Med Microbiol 2019 Feb 12. Epub 2019 Feb 12.

1​Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, ul. Dębinki 7, 80-952 Gdańsk, Poland.

Purpose: To analyse the role of virulence factors (VFs) and host in Klebsiella pneumoniae upper urinary tract infections (UTIs) in renal transplant (RTx) recipients.

Methodology: Clinical and demographic data were registered prospectively. Phylogenetic background of K. Read More

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http://dx.doi.org/10.1099/jmm.0.000942DOI Listing
February 2019

Utility of Combination Antimicrobial Therapy in Adults with Bloodstream Infections due to Enterobacteriaceae and Non-Fermenting Gram-Negative Bacilli Based on In Vitro Analysis at Two Community Hospitals.

Antibiotics (Basel) 2019 Feb 8;8(1). Epub 2019 Feb 8.

Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina College of Pharmacy, Columbia, SC 29208, USA.

This study examined the utility of combination therapy for bloodstream isolates of and non-fermenting Gram-negative bacilli (NFGN) from adults at two community hospitals from January 2010 through to June 2015. Changes to in vitro antimicrobial susceptibilities by adding ciprofloxacin or gentamicin to third-generation cephalosporins (3GC) were examined overall and in patients with risk factors for 3GC resistance. Overall ceftriaxone susceptibility among was 996/1063 (94%) and 247/295 (84%) in patients with 3GC resistance risk factors. Read More

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http://dx.doi.org/10.3390/antibiotics8010015DOI Listing
February 2019

Orthopedic Implant-Associated Infection by Multidrug Resistant .

J Clin Med 2019 Feb 8;8(2). Epub 2019 Feb 8.

Department of Clinical Microbiology, Hospital Universitario Fundación Jiménez Díaz. IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain.

Introduction: Orthopedic implant-associated infections caused by multidrug-resistant are a growing challenge for healthcare providers due to their increasing incidence and the difficulties of medical and surgical treatment.

Material And Methods: A retrospective observational study of all cases of multidrug resistant orthopedic implant-associated infection diagnosed in a tertiary European hospital from December 2011 to November 2017 was carried out. Clinical records were reviewed using a previously designed protocol. Read More

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http://dx.doi.org/10.3390/jcm8020220DOI Listing
February 2019

The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification.

Nat Microbiol 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

When choosing antibiotics to treat bacterial infections, it is assumed that the susceptibility of the target bacteria to an antibiotic is reflected by laboratory estimates of the minimum inhibitory concentration (MIC) needed to prevent bacterial growth. A caveat of using MIC data for this purpose is heteroresistance, the presence of a resistant subpopulation in a main population of susceptible cells. We investigated the prevalence and mechanisms of heteroresistance in 41 clinical isolates of the pathogens Escherichia coli, Salmonella enterica, Klebsiella pneumoniae and Acinetobacter baumannii against 28 different antibiotics. Read More

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http://dx.doi.org/10.1038/s41564-018-0342-0DOI Listing
February 2019

Appropriate Treatment for Bloodstream Infections Due to Carbapenem-Resistant and : A Nationwide Multicenter Study in Taiwan.

Open Forum Infect Dis 2019 Feb 17;6(2):ofy336. Epub 2018 Dec 17.

Division of Infectious Diseases, Sijhih Cathy General Hospital, New Taipei City, Taiwan.

Background: In a multicenter study from Taiwan, we aimed to investigate the outcome of patients who received different antimicrobial therapy in carbapenem-resistant Enterobacteriaceae bloodstream infections and proposed a new definition for tigecycline use.

Methods: Patients from 16 hospitals in Taiwan who received appropriate therapy for bloodstream infections due to carbapenem-resistant and were enrolled in the study between January 2012 and June 2015. We used a cox proportional regression model for multivariate analysis to identify independent risk factors of 14-day mortality. Read More

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http://dx.doi.org/10.1093/ofid/ofy336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362312PMC
February 2019

Prevalence of pks gene cluster and characteristics of Klebsiella pneumoniae-induced bloodstream infections.

J Clin Lab Anal 2019 Feb 8:e22838. Epub 2019 Feb 8.

Department of Clinical Laboratory, Xiangya Hospital Central South University, Changsha, China.

Background: The emerging pks-positive (pks ) strains have aroused great public concern recently. Colibactin, encoded by pks gene cluster, has been reported to be involved in DNA damage and increased virulence. Little is known about its prevalence among Klebsiella pneumoniae-induced bloodstream infections (BSIs). Read More

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http://dx.doi.org/10.1002/jcla.22838DOI Listing
February 2019

Polymicrobial Bacteremia Involving Klebsiella pneumoniae in Patients with Complicated Intra-Abdominal Infections: Frequency, Co-Pathogens, Risk Factors, and Clinical Outcomes.

Surg Infect (Larchmt) 2019 Feb 8. Epub 2019 Feb 8.

1 Department of Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China.

Background: Klebsiella pneumoniae has gained notoriety because of its high antibiotic resistance and mortality. We compared the clinical features and outcomes of polymicrobial bacteremia involving K. pneumoniae (PBKP). Read More

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http://dx.doi.org/10.1089/sur.2018.207DOI Listing
February 2019
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1.721 Impact Factor

Using the best available data to estimate the cost of antimicrobial resistance: a systematic review.

Antimicrob Resist Infect Control 2019 1;8:26. Epub 2019 Feb 1.

4University of Chichester, West Sussex, UK.

Background: Valuation of the economic cost of antimicrobial resistance (AMR) is important for decision making and should be estimated accurately. Highly variable or erroneous estimates may alarm policy makers and hospital administrators to act, but they also create confusion as to what the most reliable estimates are and how these should be assessed. This study aimed to assess the quality of methods used in studies that quantify the costs of AMR and to determine the best available evidence of the incremental cost of these infections. Read More

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http://dx.doi.org/10.1186/s13756-019-0472-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359818PMC
February 2019
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Colonization of intestinal microbiota with carbapenemase-producing Enterobacteriaceae in paediatric intensive care units in Cairo, Egypt.

Arab J Gastroenterol 2019 Feb 4. Epub 2019 Feb 4.

Botany and Microbiology Department, Faculty of Science, Cairo University, Cairo, Egypt.

Background And Study Aims: Colonized patients with carbapenamase producing Enterobacteriaceae (CPE) are vulnerable to invasive infections from their endogenous flora. We aimed to assess faecal colonization with (CPE) among children admitted to Cairo University paediatric intensive care units (ICUs). The phenotypic and genotypic characterizations of carbapenemase-producing Enterobacteriaceae were also studied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16871979193000
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http://dx.doi.org/10.1016/j.ajg.2019.01.002DOI Listing
February 2019
3 Reads

Study the antibacterial and antibiofilm activity of Carum copticum against antibiotic-resistant bacteria in planktonic and biofilm forms.

Microb Pathog 2019 Feb 4;129:99-105. Epub 2019 Feb 4.

Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.

Objectives: Microbial biofilms has attracted interest in the recent years because they has become the most important cause of nosocomial infections. This study was aimed to examine the antibacterial activities of Carum copticum extracts on the development of microbial biofilms and planktonic form of six pathogenic bacteria.

Methods: Antimicrobial activity of the crude extracts against the planktonic form of six pathogenic bacteria: Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii and Klebsiella pneumonia was evaluated by using the disc diffusion method. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.002DOI Listing
February 2019
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Outcome Following the Treatment of Ventriculitis Caused by Multi/Extensive Drug Resistance Gram Negative Bacilli; and .

Front Neurol 2018 23;9:1174. Epub 2019 Jan 23.

Neurosurgery Department, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

CNS ventriculitis is a serious complication following an intracranial insult that demands immediate treatment with broad-spectrum antibiotics in a critical care setting. Infections due to multi/extensive drug resistance (MDR/XDR) microorganisms are very challenging, which may demand an additional approach to the ongoing practice; intravenous and intraventricular administration of antibiotics. To study the efficacy and safety of thorough ventricular irrigation followed by daily intraventricular antibiotic administration in patients with MDR/XDR ventriculitis. Read More

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http://dx.doi.org/10.3389/fneur.2018.01174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352847PMC
January 2019
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Evaluation of Lactobacilli for Antagonistic Activity Against the Growth, Adhesion and Invasion of and .

Indian J Microbiol 2019 Mar 27;59(1):81-89. Epub 2018 Jul 27.

2Department of Food and Nutrition, Providence University, Taichung City, 43301 Taiwan, ROC.

Urinary tract infections are the most common infectious diseases in babies and the elderly and are often acquired as nosocomial infections. The purpose of the present study was to identify strains of lactic acid bacteria (LAB) which could be used as alternatives to antibiotics for the treatment of urinary tract infections because of their ability to inhibit urinary tract pathogens ( BCRC 10694 and BCRC 17040). We screened 370 LAB strains using spent culture supernatants by inhibition zone assay to assess their antimicrobial effects. Read More

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http://dx.doi.org/10.1007/s12088-018-0753-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328402PMC
March 2019
1 Read

High Prevalence of Multidrug-Resistant Harboring Several Virulence and β-Lactamase Encoding Genes in a Brazilian Intensive Care Unit.

Front Microbiol 2018 22;9:3198. Epub 2019 Jan 22.

Departamento de Genética e Evolução, Universidade Federal de São Carlos, São Carlos, Brazil.

is an important opportunistic pathogen that commonly causes nosocomial infections and contributes to substantial morbidity and mortality. We sought to investigate the antibiotic resistance profile, pathogenic potential and the clonal relationships between ( = 25) isolated from patients and sources at a tertiary care hospital's intensive care units (ICUs) in the northern region of Brazil. Most of isolates ( = 21, 84%) were classified as multidrug resistant (MDR) with high-level resistance to β-lactams, aminoglycosides, quinolones, tigecycline, and colistin. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349766PMC
January 2019

Intravenous fluid contaminated with Klebsiella oxytoca as a source of sepsis in a preterm newborn: Case report.

Am J Infect Control 2019 Feb 2. Epub 2019 Feb 2.

Department of Pediatrics and Child Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; Maternal, Newborn, Child Health and Childhood HIV, TB and Malaria, Geneva, Switzerland.

Advances in neonatal care have led to the increasing survival of smaller and sicker infants, but nosocomial infections continue to be a serious problem, associated with increased mortality rates, immediate and long-term morbidity, prolonged hospital stay, and increased cost of care. We report a case of hospital-acquired sepsis in a preterm baby secondary to Klebsiella oxytoca, resulting from contaminated intravenous fluid. Read More

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http://dx.doi.org/10.1016/j.ajic.2018.12.025DOI Listing
February 2019
8 Reads

Combination therapy with polymyxin B for carbapenemase-producing Klebsiella pneumoniae bloodstream infection.

Int J Antimicrob Agents 2019 Feb 26;53(2):152-157. Epub 2018 Oct 26.

Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; Department of Internal Medicine, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Infectious Diseases Service, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil. Electronic address:

Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) bloodstream infections (BSIs) are related to high mortality rates, and combination therapy has been associated with lower mortality in patients treated mostly with colistin. There is a paucity of studies addressing polymyxin B (PMB) treatment for KPC-KP infections. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2018.10.010DOI Listing
February 2019

Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017.

Euro Surveill 2019 Jan;24(5)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Following the rapid increase of infections due to carbapenemase-producing Enterobacteriaceae (CPE) in Italy, the national surveillance of bloodstream infections (BSI) due to CPE ( and ) was instituted in 2013. All CPE-BSI cases reported to the surveillance in the years 2014-17 were analysed in order to investigate incidence rate (IR), trend, main individual characteristics and enzymes involved in CPE resistance. Throughout this period, 7,632 CPE-BSI cases (IR: 3. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800159DOI Listing
January 2019

Activity of ceftolozane-tazobactam and comparators when tested against Gram-negative isolates collected from paediatric patients in the United States and Europe during 2012-2016 as part of a global surveillance programme.

Int J Antimicrob Agents 2019 Feb 1. Epub 2019 Feb 1.

JMI Laboratories, North Liberty, Iowa, USA.

Ceftolozane-tazobactam (C-T) is a combination of an antipseudomonal cephalosporin and a β-lactamase inhibitor. C-T was approved by the US Food and Drug Administration in 2014 and by the European Medicine Agency in 2015 for use in adults to treat complicated urinary tract infections, acute pyelonephritis, and complicated intra-abdominal infections with metronidazole. Studies for paediatric indications are planned. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.01.015DOI Listing
February 2019
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Protective and therapeutic application of the depolymerase derived from a novel KN1 genotype of Klebsiella pneumoniae bacteriophage in mice.

Res Microbiol 2019 Feb 1. Epub 2019 Feb 1.

Department of Respiratory and Critical Care Diseases, 307th Hospital of PLA, No. 8 Dongda Street, Fengtai District, Beijing, China, 100071. Electronic address:

Klebsiella pneumoniae is one of the major Gram-negative bacterial pathogens causing hospital-acquired multidrug-resistant infections, and the antimicrobial treatment options are scarce. The lack of available antimicrobials has prompted the development of alternative strategies for the treatment of these infections. In this study, a K. Read More

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http://dx.doi.org/10.1016/j.resmic.2019.01.003DOI Listing
February 2019

Prospective surveillance of bacterial colonization and primary sepsis - findings of a tertiary neonatal intensive and intermediate care unit.

J Hosp Infect 2019 Feb 1. Epub 2019 Feb 1.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany. Electronic address:

Background: Preterm infants and critically ill neonates are predisposed to nosocomial infections as sepsis. Moreover, these infants acquire commensal bacteria, which might become potentially harming. On-ward transmission of these bacteria can cause outbreaks. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.01.021DOI Listing
February 2019
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Monomicrobial gram-negative necrotizing fasciitis: An uncommon but fatal syndrome.

Diagn Microbiol Infect Dis 2019 Jan 4. Epub 2019 Jan 4.

Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea. Electronic address:

This study aimed to characterize patients with monomicrobial gram-negative necrotizing fasciitis in three university hospitals in Korea. In this study, of the 115 patients with community-acquired necrotizing fasciitis, 67 (58%) had monomicrobial infections: 31 (27%) in the gram-negative group and 36 (31%) in the gram-positive group. The majority of patients in the gram-negative group were infected with Escherichia coli followed by Klebsiella pneumoniae and Vibrio vulnificus. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.12.013DOI Listing
January 2019
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Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.

Drugs 2019 Feb 2. Epub 2019 Feb 2.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by Shionogi & Co., Ltd., Japan. Read More

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http://dx.doi.org/10.1007/s40265-019-1055-2DOI Listing
February 2019
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Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types.

Microb Biotechnol 2019 Jan 31. Epub 2019 Jan 31.

Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan.

Klebsiella pneumoniae is an important human pathogen causing opportunistic nosocomial and community-acquired infections. A major public health concern regarding K. pneumoniae is the increasing incidence of multidrug-resistant strains. Read More

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http://dx.doi.org/10.1111/1751-7915.13370DOI Listing
January 2019

The Search for Natural Inhibitors of Biofilm Formation and the Activity of the Autoinductor C6-AHL in ATCC 13884.

Biomolecules 2019 Jan 30;9(2). Epub 2019 Jan 30.

Grupo de Química Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Calle 67 No. 53⁻10, Medellín 050010, Colombia.

Human nosocomial infections are common around the world. One of the main causes is the bacteria , which shows high rates of resistance to antibiotics. Thus, drugs with novel mechanisms of action are needed. Read More

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http://dx.doi.org/10.3390/biom9020049DOI Listing
January 2019
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[Looking back 2018--focused on surgical infection].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Jan;22(1):17-21

Department of General Surgery, Jinling Hospital, Nanjing Medical School of Nanjing University, Nanjing 210002, China.

The published clinical research in 2018 in surgical infection are changing current opinions in the management of acute appendicitis, antibiotics usage, resuscitation of septic shock, and choice of nutritional therapy in critically ill patients. In the management of uncomplicated acute appendicitis, antibiotic therapy can be successful in selected patients who wish to avoid surgery. Delayed primary wound closure can not reduce superficial surgical site infection rates compared to primary wound closure for complicated appendicitis. Read More

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January 2019
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Clinical, etiological and antimicrobial susceptibility profile of pediatric urinary tract infections in a tertiary care hospital of Nepal.

BMC Pediatr 2019 Jan 29;19(1):36. Epub 2019 Jan 29.

Department of Microbiology and Infectious Diseases, B. P. Koirala Institute of Health Sciences, Dharan, Sunsari, 56700, Nepal.

Background: Urinary tract infection (UTI) is one of most common pediatric infections. The study was designed to assess the clinical profile, common bacterial microorganisms causing UTI and their antimicrobial susceptibility patterns at B. P. Read More

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http://dx.doi.org/10.1186/s12887-019-1410-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350346PMC
January 2019
1 Read

[New antibiotics in infection treatment].

Authors:
Tadeusz Płusa

Pol Merkur Lekarski 2018 Dec;45(270):213-219

Medical Faculty of Łazarski University of Warsaw, Poland.

The introduction of new molecules with antimicrobial activity is an opportunity for modern antibiotic therapy in the era of rapidly growing resistance to antibiotics. Beta-lactamase-inhibiting antibiotics, cephalosporinases and carbapenemases represent a breakthrough in previous treatments for infections caused by resistant pathogens. Ceftazidime with avibactam and ceftolozane with tazobactam show exceptional efficacy in severe infections. Read More

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December 2018

Whole genome sequencing reveals resemblance between ESBL-producing and carbapenem resistant Klebsiella pneumoniae isolates from Austrian rivers and clinical isolates from hospitals.

Sci Total Environ 2019 Jan 20;662:227-235. Epub 2019 Jan 20.

Austrian Agency for Health and Food Safety, Institute for Medical Microbiology and Hygiene, Vienna, Austria; University of Natural Resources and Life Sciences, Department of Biotechnology, Vienna, Austria.

In 2016, the Austrian Agency for Health and Food Safety started a pilot project to investigate antimicrobial resistance in surface water. Here we report on the characterisation of carbapenem resistant and ESBL-producing K. pneumoniae isolates from Austrian river water samples compared to 95 clinical isolates recently obtained in Austrian hospitals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193019
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http://dx.doi.org/10.1016/j.scitotenv.2019.01.179DOI Listing
January 2019
4 Reads

ChloS-HRM, a novel assay to identify chloramphenicol-susceptible Escherichia coli and Klebsiella pneumoniae in Malawi.

J Antimicrob Chemother 2019 Jan 25. Epub 2019 Jan 25.

Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, UK.

Objectives: Chloramphenicol is a broad-spectrum antimicrobial widely available in sub-Saharan Africa. With susceptibility re-emerging among Enterobacteriaceae in Blantyre, Malawi, we designed and evaluated a new high-resolution melt (HRM) RT-PCR assay, ChloS-HRM, to identify chloramphenicol-susceptible infections in a hospital setting.

Methods: Seventy-two previously whole-genome sequenced isolates of Escherichia coli and Klebsiella pneumoniae from the Queen Elizabeth Central Hospital, Malawi, were subjected to determination of chloramphenicol MICs. Read More

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http://dx.doi.org/10.1093/jac/dky563DOI Listing
January 2019
1 Read

Prevalence of extended-spectrum-β-lactamase-producing Klebsiella pneumonia: first systematic review and meta-analysis from Iran.

J Glob Antimicrob Resist 2019 Jan 24. Epub 2019 Jan 24.

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: Extended-spectrum β-lactamases- producing Klebsiella pneumonia (ESBL-KP) have emerged as an important pathogen causing severe infection thought the world. Infections due to ESBL-KP are associated with high morbidity and mortality, especially in developing countries such as Iran. The aim of current study was to assess the pooled prevalence of ESBL-KP with different gene variants in Iran. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.01.020DOI Listing
January 2019
3 Reads

Deciphering risk factors for blood stream infections, bacteria species and antimicrobial resistance profiles among children under five years of age in North-Western Tanzania: a multicentre study in a cascade of referral health care system.

BMC Pediatr 2019 Jan 26;19(1):32. Epub 2019 Jan 26.

Department of Microbiology and Immunology, Weill-Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.

Background: Blood stream infections (BSIs) cause a complex cascade of inflammatory events, resulting in significant morbidity and mortality in children in Tanzania. This study was designed to delineate circulating bacterial species, antimicrobial resistance (AMR) profiles and risk factors for BSIs and mortality among children in the cascade of referral health care facilities so as to guide comprehensive BSIs management.

Methods: A multiple cross sectional analytical study was conducted between July 20, 2016 to October 04, 2017 involving 950 children less than five years of age in the North-western part of Tanzania. Read More

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http://dx.doi.org/10.1186/s12887-019-1411-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347777PMC
January 2019
1 Read

[Characterization of Klebsiella pneumoniae strains exposed to subinhibitory concentrations of chlorhexidine].

Mikrobiyol Bul 2019 Jan;53(1):114-117

Gazi University Faculty Of Medicine, Department of Medical Microbiology, Ankara, Turkey.

Chlorhexidine, a topical antiseptic, acts as a cationic biguanide altering the osmotic transport of the bacterial cell wall that has been used throughout the world to prevent healthcare-associated infections for decades. The routine application of chlorhexidine can result in decreased susceptibility of bacteria over time. The aim of this study was to develop Klebsiella pneumoniae strains after exposure to chlorhexidine and characterize these adapted strains in terms of their virulence ability both by in vivo and in vitro methods. Read More

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http://dx.doi.org/10.5578/mb.67793DOI Listing
January 2019
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Co-outbreak of multidrug resistance and a novel ST3006 Klebsiella pneumoniae in a neonatal intensive care unit: A retrospective study.

Medicine (Baltimore) 2019 Jan;98(4):e14285

Shengli Clinical Medical College of Fujian Medical University.

The outbreak of carbapenem-resistant Klebsiella pneumoniae is a serious public health problem, especially in the neonatal intensive care unit (NICU).Fifteen K. pneumoniae strains were isolated from 7 neonates during June 3 to 28, 2017 in an NICU. Read More

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http://dx.doi.org/10.1097/MD.0000000000014285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358387PMC
January 2019
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The role of therapy with aminoglycoside in the outcomes of kidney transplant recipients infected with polymyxin- and carbapenem-resistant Enterobacteriaceae.

Eur J Clin Microbiol Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Department of Infectious Diseases, University of São Paulo School of Medicine Hospital das Clínicas, São Paulo, Brazil.

Kidney transplant recipients are at risk for infections due to carbapenem-resistant Enterobacteriaceae (CRE). Polymyxin-resistant CRE (PR-CRE) infections are especially difficult to treat. The aim of this study was to characterize PR-CRE infections among kidney transplant recipients and identify risk factors for treatment failure. Read More

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http://link.springer.com/10.1007/s10096-019-03468-4
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http://dx.doi.org/10.1007/s10096-019-03468-4DOI Listing
January 2019
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Can surgical site infections be controlled through microbiological surveillance? A three-year laboratory-based surveillance at an orthopaedic unit, retrospective observatory study.

Int Orthop 2019 Jan 24. Epub 2019 Jan 24.

Medical University of Silesia, Katowice, Poland.

Objective: The aims of the study were to analyse the surgical site infections (SSIs) in patients operated at an orthopaedic ward and to describe the drug-resistance of the aetiology of those infections. Also, analyse the possibility of SSI control through microbiological surveillance. Additionally, we have studied the information inferred by aggregating cumulative antibiograms for the SSIs of the studied orthopaedic unit. Read More

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http://link.springer.com/10.1007/s00264-019-04298-x
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http://dx.doi.org/10.1007/s00264-019-04298-xDOI Listing
January 2019
2 Reads

Evaluation of a modified protocol that decreases the turnaround time of positive blood cultures.

Iran J Microbiol 2018 Oct;10(5):281-286

Department of Microbiology, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India.

Background And Objectives: Neonatal septicemia can be rapidly fatal if not treated promptly. A speedy laboratory diagnosis would improve the outcome. The BacT/ALERT 3D system (bioMerieux, Durham, North Carolina) is currently being used for laboratory diagnosis of blood stream infections. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339999PMC
October 2018

Characterization of post-surgical critical patients with infections associated with healthcare after prolonged perfusion of remifentanil.

Rev Assoc Med Bras (1992) 2018 Aug;64(8):736-742

. Departamento de Farmacología e Instituto de Neurociencias. Facultad de Medicina, Universidad de Granada, Granada, Spain.

Introduction: Healthcare associated infections (HAI) are the most frequent complication of hospitalized patients. The aim of this study was to describe the clinical and epidemiological characteristics of critically ill post-surgical patients with a diagnosis of healthcare associated infections, after a pattern of sedoanalgesia of at least 4 days.

Methods: All patients over 18 years of age with a unit admission of more than 4 days were consecutively selected. Read More

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http://dx.doi.org/10.1590/1806-9282.64.08.736DOI Listing
August 2018
2 Reads

Bacterial and Viral Identification Rate in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Korea.

Yonsei Med J 2019 Feb;60(2):216-222

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.

Purpose: The most common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is respiratory infection. Most studies of bacterial or viral cause in AECOPD have been conducted in Western countries. We investigated bacterial and viral identification rates in AECOPD in Korea. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.2.216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342712PMC
February 2019
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Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor.

Authors:
Chao Liu Jun Guo

Ann Clin Microbiol Antimicrob 2019 Jan 21;18(1). Epub 2019 Jan 21.

Department of Respiratory Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 Litang Road, Changping District, Beijing, 102218, China.

Background: The definition of hypervirulent Klebsiella pneumoniae (hvKp), traditionally regarded as hypermucoviscosity, is controversial. However, data based on both phenotype (hypermucoviscous) and genetic (aerobactin) criteria are limited.

Methods: A retrospective study was conducted in 175 geriatric patients between January 2008 and January 2014. Read More

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http://dx.doi.org/10.1186/s12941-018-0302-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341648PMC
January 2019
2 Reads

A novel framework to compare the effectiveness of β-lactamase inhibitors against extended-spectrum β-lactamase-producing Enterobacteriaceae.

Clin Microbiol Infect 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX, USA; Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, TX, USA. Electronic address:

Objectives: Extended-spectrum β-lactamases (ESBLs) present a serious challenge in the treatment of Gram-negative bacterial infections. ESBLs mediate resistance to most β-lactams, which may be reversed with the addition of an active β-lactamase inhibitor (such as tazobactam, relebactam and avibactam). However, various ESBLs may exhibit different susceptibilities to these inhibitors, which could impact efficacy. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.003DOI Listing
January 2019
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Adding double carbapenem therapy to the armamentarium against carbapenem-resistant Enterobacteriaceae bloodstream infections.

Infect Dis (Lond) 2019 Jan 21:1-7. Epub 2019 Jan 21.

d University of Georgia College of Pharmacy, Clinical and Administrative Pharmacy Department , Albany , GA , USA.

Background: Carbapenem-resistant Enterobacteriaceae (CRE) constitute a threat, since they cause infections with high mortality rates. Historically, polymyxin-based therapies have been the regimens of choice for CRE bloodstream infection (BSI). Recent studies have shown improved outcomes with β-lactam-based therapies, including double carbapenem regimens for CRE BSIs compared to polymyxin-based regimens. Read More

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http://dx.doi.org/10.1080/23744235.2018.1527470DOI Listing
January 2019
10 Reads