23,249 results match your criteria Klebsiella Infections


Outcomes and Risk Factors of Bloodstream Infections Caused by Carbapenem-Resistant and Non-Carbapenem-Resistant in China.

Infect Drug Resist 2022 17;15:3161-3171. Epub 2022 Jun 17.

School of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan Province, People's Republic of China.

Purpose: To compare antimicrobial resistance, virulence, clinical characteristics, and risk factors between carbapenem-resistant (CRKP) and carbapenem-susceptible (CSKP) isolates from patients with bloodstream infections (BSIs) in China.

Patients And Methods: The clinical data of 103 patients with BSI from 10 hospitals were retrospectively analyzed. The minimum inhibitory concentrations of 15 antibiotics against the bacteria were determined. Read More

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Multi-system : A tale of destruction form lung to eye.

SAGE Open Med Case Rep 2022 16;10:2050313X221105157. Epub 2022 Jun 16.

Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka, Colombo, Sri Lanka.

, found in the gastrointestinal flora is a causative agent of hospital-acquired infections. Although isolated organ infections are common, reports of multi-system involvement are rare. We report on a susceptible patient presenting with disseminated infection with concurrent multi-organ disease involving the lung, liver, prostate and eye. Read More

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A New Live Auxotrophic Vaccine Induces Cross-Protection against Infections in Mice.

Vaccines (Basel) 2022 Jun 16;10(6). Epub 2022 Jun 16.

Department of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.

The development of a whole-cell vaccine from bacteria auxotrophic for D-amino acids present in the bacterial cell wall is considered a promising strategy for providing protection against bacterial infections. Here, we constructed a prototype vaccine, consisting of a glutamate racemase-deficient mutant, for preventing infections. The deletion mutant lacks the gene and requires exogenous addition of D-glutamate for growth. Read More

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Biosensors for with Molecularly Imprinted Polymer (MIP) Technique.

Sensors (Basel) 2022 Jun 20;22(12). Epub 2022 Jun 20.

Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

Nosocomial infection is one of the most important problems that occurs in hospitals, as it directly affects susceptible patients or patients with immune deficiency. ( is the most common cause of nosocomial infections in hospitals. can cause various diseases such as pneumonia, urinary tract infections, septicemias, and soft tissue infections, and it has also become highly resistant to antibiotics. Read More

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In-Vitro Antibacterial Activity of Curcumin-Loaded Nanofibers Based on Hyaluronic Acid against Multidrug-Resistant ESKAPE Pathogens.

Pharmaceutics 2022 May 31;14(6). Epub 2022 May 31.

Saint-Petersburg Pasteur Institute, Street Mira, 14, 197101 St. Petersburg, Russia.

Bacterial infections have accompanied humanity throughout its history and became vitally important in the pandemic area. The most pathogenic bacteria are multidrug-resistant strains, which have become widespread due to their natural biological response to the use of antibiotics, including uncontrolled use. The current challenge is finding highly effective antibacterial agents of natural origin, which, however, have low solubility and consequently poor bioavailability. Read More

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Inhibitors of -Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria.

Pharmaceuticals (Basel) 2022 Jun 20;15(6). Epub 2022 Jun 20.

P4T Group, Food and Drug Department, University of Parma, 43124 Parma, Italy.

Antibacterial adjuvants are of great significance, since they allow one to downscale the therapeutic dose of conventional antibiotics and reduce the insurgence of antibacterial resistance. Herein, we report that -acetylserine sulfhydrylase (OASS) inhibitors could be used as colistin adjuvants to treat infections caused by critical pathogens spreading worldwide, , serovar Typhimurium, and . Starting from a hit compound endowed with a nanomolar dissociation constant, we have rationally designed and synthesized a series of derivatives to be tested against Typhimurium OASS isoenzymes, StOASS-A and StOASS-B. Read More

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Recent Advances in the Use of Molecular Methods for the Diagnosis of Bacterial Infections.

Pathogens 2022 Jun 8;11(6). Epub 2022 Jun 8.

Department of Human Pathology, University of Messina, 98125 Messina, Italy.

Infections caused by bacteria have a major impact on public health-related morbidity and mortality. Despite major advances in the prevention and treatment of bacterial infections, the latter continue to represent a significant economic and social burden worldwide. The WHO compiled a list of six highly virulent multidrug-resistant bacteria named ESKAPE (, , , , , and species) responsible for life-threatening diseases. Read More

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PDIA, an Iminosugar Compound with a Wide Biofilm Inhibitory Spectrum Covering Both Gram-Positive and Gram-Negative Human Bacterial Pathogens.

Microorganisms 2022 Jun 15;10(6). Epub 2022 Jun 15.

Department of Bacteriology, Microbial Ecology and Parasitology, Chair of Microbiology, Jagiellonian University Medical College, 31-121 Cracow, Poland.

Many difficult-to-treat human infections related to catheters and other indwelling devices are caused by bacteria residing in biofilms. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. Therefore, many different approaches have been researched to destroy or inhibit biofilm production by bacteria. Read More

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Enhanced Antibiotic Tolerance of an Multispecies Uropathogen Biofilm Model, Useful for Studies of Catheter-Associated Urinary Tract Infections.

Microorganisms 2022 Jun 13;10(6). Epub 2022 Jun 13.

Section of Microbiology, Department of Biology, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark.

Catheter-associated urinary tract infections (CAUTI) are a common clinical concern as they can lead to severe, persistent infections or bacteremia in long-term catheterized patients. This type of CAUTI is difficult to eradicate, as they are caused by multispecies biofilms that may have reduced susceptibility to antibiotics. Many new strategies to tackle CAUTI have been proposed in the past decade, including antibiotic combination treatments, surface modification and probiotic usage. Read More

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Whole Genome Characterization of the High-Risk Clone ST383 with a Simultaneous Carriage of on IncL/M Plasmid and on Convergent IncHI1B/IncFIB Plasmid from Egypt.

Microorganisms 2022 May 26;10(6). Epub 2022 May 26.

Department of Microbiology and Immunology, Faculty of Pharmacy, Alexandria University, El-Khartoom Square, Azarita, Alexandria 25435, Egypt.

Recently, Egypt has witnessed the emergence of multidrug-resistant (MDR) which has posed a serious healthcare challenge. The accelerated dissemination of genes among these MDR , particularly and , have been noted. In this study, we investigated the occurrence of among recovered from the laboratory of a major hospital in Alexandria. Read More

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Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen.

Antibiotics (Basel) 2022 Jun 14;11(6). Epub 2022 Jun 14.

Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai 200040, China.

Colistin methanesulfonate (CMS) is an important treatment option for infections caused by carbapenem-resistant Gram-negative organisms (CROs). This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) profiles and safety of CMS in Chinese subjects following a recommended dosage. A total of 12 healthy Chinese subjects received CMS injections at 2. Read More

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Bacterial Resistance to Antibiotics and Clonal Spread in COVID-19-Positive Patients on a Tertiary Hospital Intensive Care Unit, Czech Republic.

Antibiotics (Basel) 2022 Jun 8;11(6). Epub 2022 Jun 8.

Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 779 00 Olomouc, Czech Republic.

This observational retrospective study aimed to analyze whether/how the spectrum of bacterial pathogens and their resistance to antibiotics changed during the worst part of the COVID-19 pandemic (1 November 2020 to 30 April 2021) among intensive care patients in University Hospital Olomouc, Czech Republic, as compared with the pre-pandemic period (1 November 2018 to 30 April 2019). A total of 789 clinically important bacterial isolates from 189 patients were cultured during the pre-COVID-19 period. The most frequent etiologic agents causing nosocomial infections were strains of (17%), (11%), (10%), coagulase-negative staphylococci (9%), (8%), (6%), (5%), (5%) and (5%). Read More

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Revisiting the Frequency and Antimicrobial Resistance Patterns of Bacteria Implicated in Community Urinary Tract Infections.

Antibiotics (Basel) 2022 Jun 3;11(6). Epub 2022 Jun 3.

Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

Urinary tract infections (UTIs) are one of the most common infectious diseases at the community level. The continue misuse of antimicrobials is leading to an increase in bacterial resistance, which is a worldwide problem. The objective of this work was to study the incidence and pattern of antimicrobial resistance of the main bacteria responsible for UTI in the community of central and northern Portugal, and establish an appropriate empirical treatment. Read More

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Heteroaryl-Ethylenes as New Effective Agents for High Priority Gram-Positive and Gram-Negative Bacterial Clinical Isolates.

Antibiotics (Basel) 2022 Jun 3;11(6). Epub 2022 Jun 3.

Section of Microbiology, Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy.

The World Health Organization has identified antimicrobial resistance as a public health emergency and developed a global priority pathogens list of antibiotic-resistant bacteria that can be summarized in the acronym ESKAPE (, , , , and species), reminding us of their ability to escape the effect of antibacterial drugs. We previously tested new heteroaryl-ethylene compounds in order to define their spectrum of activity and antibacterial capability. Now, we focus our attention on PB4, a compound with promising MIC and MBC values in all conditions tested. Read More

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The Rapid Emergence of Ceftazidime-Avibactam Resistance Mediated by KPC Variants in Carbapenem-Resistant in Zhejiang Province, China.

Antibiotics (Basel) 2022 May 30;11(6). Epub 2022 May 30.

Department of Clinical Laboratory, School of Medicine, Second Affiliated Hospital of Zhejiang University, Hangzhou 310000, China.

Ceftazidime-avibactam (CAV) is a new treatment option against carbapenem-resistant (CRKP) infections. However, the rapid emergence of CAV resistance mediated by KPC variants has posed a severe threat to healthcare after its clinical application. The characteristics of CAV resistance in CRKP strains needs to be determined in China. Read More

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Microbiological Characterisation of Community-Acquired Urinary Tract Infections in Bagamoyo, Tanzania: A Prospective Study.

Trop Med Infect Dis 2022 Jun 12;7(6). Epub 2022 Jun 12.

Institute of Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Germany.

Urinary tract infections (UTIs) are among the most common infections in sub-Saharan Africa, but microbiological data to guide treatment decisions are limited. Hence, we investigated the bacterial aetiology and corresponding antimicrobial susceptibility patterns in outpatients with UTIs in Bagamoyo, Tanzania. Urine samples from symptomatic individuals were subjected to microbiological examinations for bacterial species identification using conventional methods and disc diffusion-based resistance testing. Read More

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Colonization of White-Tailed Deer (Odocoileus virginianus) from Urban and Suburban Environments with Cephalosporinase- and Carbapenemase-Producing Enterobacterales.

Appl Environ Microbiol 2022 Jun 23:e0046522. Epub 2022 Jun 23.

Department of Veterinary Preventive Medicine, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.

Wildlife play a role in the acquisition, maintenance, and dissemination of antimicrobial resistance (AMR). This is especially true at the human-domestic animal-wildlife interface, like urbanized areas, where interactions occur that can promote the cross-over of AMR bacteria and genes. We conducted a 2-year fecal surveillance ( = 783) of a white-tailed deer (WTD) herd from an urban park system in Ohio to identify and characterize cephalosporin-resistant and carbapenemase-producing bacteria using selective enrichment. Read More

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Multicenter Evaluation of the Novel ETEST Fosfomycin for Antimicrobial Susceptibility Testing of Enterobacterales, Enterococcus faecalis, and Staphylococcus Species.

J Clin Microbiol 2022 Jun 23:e0002122. Epub 2022 Jun 23.

bioMérieux, La Balme les Grottes, France.

Fosfomycin is a phosphonic acid derivative active against a wide spectrum of Gram-positive and Gram-negative pathogens. It is used for the treatment of uncomplicated urinary tract infections (uUTI) or severe infections by oral or intravenous (i.v. Read More

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[Risk of infection in cancer patients colonized by extended expectrum p-lactamases and carbapenem producing Enterobacteriaceae].

Rev Chilena Infectol 2022 02;39(1):20-28

Universidad tecnológica de Pereira, Pereira, Colombia.

Background: The prevalence of multi-resistant microorganisms is a public health problem that continues to grow globally. There is a population that is mainly susceptible to being colonized and subsequently infected, and these are cancer patients.

Aim: To identify the clinical and pathological characteristics of cancer patients and their relationship with infection with ESBL and CPE producing microorganisms. Read More

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February 2022

[LAMTOR2 deficiency exacerbates Klebsiella pneumoniae-induced liver sepsis in mice].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 Jun;38(6):481-486

Department of Infectious Diseases, the Chaohu Affiliated Hospital of Anhui Medical University, Chaohu 238000; Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei 230022; Anhui Center for Surveillance of Bacterial Resistance, Hefei 230022; Institute of Bacterial Resistance, Anhui Medical University, Hefei 230022, China. *Corresponding author, E-mail:

Objective To explore the biological function and mechanisms of LAMTOR2 during Klebsiella pneumoniae(K. pneumoniae) induced liver sepsis by establishing late endosomal/lysosomal adaptor 2(LAMTOR2) gene liver conditional knockout mouse model infected by K. pneumoniae. Read More

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The threat of carbapenem resistance in Eastern Europe in patients with decompensated cirrhosis admitted to intensive care unit.

Dig Liver Dis 2022 Jun 19. Epub 2022 Jun 19.

Department of Anesthesia and Intensive Care I, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania; Anesthesia and Intensive Care Department, Regional Institute of Gastroenterology and Hepatology "Prof. Dr. Octavian Fodor", Cluj-Napoca, Romania; Outcome Research Consortium Department Cleveland, United States.

Background: Multidrug-resistant organisms are an increasing concern in patients with decompensated cirrhosis.

Aim: We aimed to evaluate the prevalence of infections with carbapenem-resistant Enterobacteriaceae in patients with decompensated cirrhosis.

Methods: Patients with decompensated cirrhosis admitted to ICU were included. Read More

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Outbreak of IncX8 Plasmid-Mediated KPC-3-Producing Enterobacterales Infection, China.

Emerg Infect Dis 2022 Jul;28(7):1421-1430

Carbapenem-resistant Enterobacterales (CRE) infection is highly endemic in China; Klebsiella pneumoniae carbapenemase (KPC) 2-producing CRE is the most common, whereas KPC-3-producing CRE is rare. We report an outbreak of KPC-3-producing Enterobacterales infection in China. During August 2020-June 2021, 25 bla-positive Enterobacteriale isolates were detected from 24 patients in China. Read More

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Epidemiological Characteristics of OXA-232-Producing Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated during Nosocomial Clonal Spread Associated with Environmental Colonization.

Microbiol Spectr 2022 Jun 22:e0257221. Epub 2022 Jun 22.

Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang Universitygrid.13402.34 School of Medicine, Hangzhou, Zhejiang Province, China.

Here, a program was designed to surveil the colonization and associated infection of OXA-232-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) (OXA-232-CRKP) in an intensive care unit (ICU) and to describe the epidemiological characteristics during surveillance. Samples were sourced from patient and environment colonization sites in the ICU from August to December 2019. During the surveillance, 106 OXA-232-CRKP strains were isolated from 8,656 samples of colonization sites, with an average positive rate of 1. Read More

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Common and distinctive genomic features of Klebsiella pneumoniae thriving in the natural environment or in clinical settings.

Sci Rep 2022 Jun 21;12(1):10441. Epub 2022 Jun 21.

Universidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005, Porto, Portugal.

The Klebsiella pneumoniae complex is comprised of ubiquitous bacteria that can be found in soils, plants or water, and as humans' opportunistic pathogens. This study aimed at inferring common and distinctive features in clinical and environmental K. pneumoniae. Read More

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Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study.

BMJ Open 2022 Jun 21;12(6):e057957. Epub 2022 Jun 21.

National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Objective: To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach.

Design: 'Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)' study was an observational prospective cohort study conducted from July 2017 to September 2019.

Setting: Government referral teaching hospitals and satellite sites in three cities in Indonesia: Semarang, Yogyakarta and Tangerang. Read More

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Exploring the therapeutic potential of acetonic plant extracts in the healing of skin wounds infected with multidrug resistant pathogens.

J Appl Biomed 2022 Jun 6;20(2):45-55. Epub 2022 Jun 6.

Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

Open wounds are easily susceptible to infection by multi-drug resistant (MDR) pathogens. The emergence of MDR super bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus spp, fungi such as Aspergillus niger and Candida spp, has been identified to significantly increase the incidence rate. Therefore, it is necessary to develop a suitable barrier to prevent infection and enhance wound healing. Read More

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Bacteraemia with an MBL-producing Klebsiella pneumoniae: treatment and the potential role of cefiderocol heteroresistance.

J Antimicrob Chemother 2022 Jun 21. Epub 2022 Jun 21.

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

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[Analysis of relationship between distribution of pathogenic microorganisms in olfactory cleft and olfactory disorders among patients with upper respiratory inflammation during the prevention and control of COVID-19].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):683-691

Department of Otorhinolaryngology Head and Neck Surgery, Capital Institute of Pediatrics, Beijing 100020, China.

To explore the relationship between pathogens in the olfactory cleft area and olfactory disorders in patients with upper respiratory inflammation (URI) during the prevention and control of 2019 novel coronavirus disease (COVID-19). A total of 234 URI patients including acute upper respiratory infection, chronic rhinosinusitis (CRS), allergic rhinitis (AR) were continuously selected from September 2020 to March 2021 in Beijing Anzhen Hospital and 98 healthy adults were enrolled as controls. The secretions from the olfactory cleft of all subjects were collected with nasal swabs under nasal endoscopy. Read More

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Prevalence of Carbapenem-Resistant Hypervirulent and Hypervirulent Carbapenem-Resistant in China Determined Mouse Lethality Tests.

Front Cell Infect Microbiol 2022 1;12:882210. Epub 2022 Jun 1.

Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Objective: To investigate the epidemiology of carbapenem-resistant hypervirulent (CR-HvKP) and hypervirulent carbapenem-resistant (Hv-CRKP).

Methods: Totally 436 strains were collected from 7 hospitals in mainland China between 2017.01 and 2018. Read More

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