8,901 results match your criteria Kimura Disease


A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice.

Arch Toxicol 2019 Apr 19. Epub 2019 Apr 19.

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, 390-8621, Japan.

Previous epidemiological studies have suggested a link between high-cholesterol intake and liver disease progression, including hepatocellular carcinoma (HCC). However, the precise mechanism of hepatotoxicity and hepatocarcinogenesis caused by excessive cholesterol consumption remains unclear. We aimed to investigate the impact of dietary cholesterol using hepatitis C virus core gene transgenic (HCVcpTg) mice, which spontaneously developed HCC with age. Read More

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http://dx.doi.org/10.1007/s00204-019-02440-7DOI Listing

Renal Artery Stenting Recovered Renal Function after Spontaneous Renal Artery Dissection: A Case Report.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiology, Chiba Emergency Medical Center, Japan.

Spontaneous renal artery dissection (SRAD) is a rare entity and the management of this disease has not been established. A 54-year-old man presented with severe flank pain, and contrast-enhanced computed tomography images suggested SRAD in his left renal artery. After two weeks of conservative treatment, stents were placed in the renal artery. Read More

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http://dx.doi.org/10.2169/internalmedicine.2550-18DOI Listing
April 2019
1 Read

Serum S100A8/A9 as a Potentially Sensitive Biomarker for Inflammatory Bowel Disease.

Lab Med 2019 Apr 17. Epub 2019 Apr 17.

Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Japan.

Background: The clinical significance of human S100A8/A9 (h-S100A8/A9) in patients with inflammatory bowel disease (IBD) is poorly understood.

Objective: To clarify whether serum S100A8/A9 is a sensitive biomarker for IBD.

Methods: Serum specimens from outpatients with IBD (n = 101) and healthy volunteers (HVs) (n = 101) were used in this study. Read More

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https://academic.oup.com/labmed/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/labmed/lmz003DOI Listing
April 2019
2 Reads

The Hepcidin-Anemia Axis: Pathogenesis of Anemia in Chronic Kidney Disease.

Contrib Nephrol 2019 16;198:124-134. Epub 2019 Apr 16.

Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan.

Background: The pathogenesis of anemia in chronic kidney disease (CKD) could be multifactorial. In recent animal studies, hepcidin knockout (KO) mice with adenine-induced CKD did not exhibit anemia and iron deficiency. Hepcidin has emerged as a major player in the development of anemia in CKD. Read More

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https://www.karger.com/Article/FullText/496636
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http://dx.doi.org/10.1159/000496636DOI Listing
April 2019
3 Reads

Anemia Management Considering the Pathophysiology of Elderly Chronic Kidney Disease Patients.

Contrib Nephrol 2019 16;198:135-143. Epub 2019 Apr 16.

Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan.

The results of previous large clinical trials have revealed that low hemoglobin (Hb) levels are significantly associated with adverse events (cardiovascular disease, infection, hospitalization, and mortality) in patients with chronic kidney disease (CKD). However, in the general population, the mean Hb levels differ by sex and age. Furthermore, the comorbidities and activities of daily living of elderly patients are markedly different from those of nonelderly patients. Read More

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https://www.karger.com/Article/FullText/496528
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http://dx.doi.org/10.1159/000496528DOI Listing
April 2019
3 Reads

Rise of blood pressure value in young patients at first visit at a dental university hospital in Japan.

J Dent Sci 2019 Mar 3;14(1):93-98. Epub 2019 Jan 3.

Educational System in Dentistry, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Japan.

Background/purpose: Hypertension is a risk factor for stroke and heart disease. Psycho-social reasons are thought to influence blood pressure fluctuation in the dental clinic, but no previous studies have investigated these relationships. In this study, we analyzed a correlation between patients' blood pressure values and their backgrounds. Read More

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http://dx.doi.org/10.1016/j.jds.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445975PMC
March 2019
1 Read

Patient preference for biologic treatments of psoriasis in Japan.

J Dermatol 2019 Apr 15. Epub 2019 Apr 15.

AbbVie GK, Tokyo, Japan.

Psoriasis is a chronic autoimmune disease affecting skin which may also manifest in nails and joints. Several biologic treatments have been approved in Japan for psoriasis. Each biologic has a different profile for efficacy and safety, including different dosing regimens and co-payment considerations which may complicate treatment decisions made by patients and physicians during short consultations. Read More

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http://dx.doi.org/10.1111/1346-8138.14870DOI Listing
April 2019
3 Reads

Tocopherol biosynthesis in (.) promastigotes.

FEBS Open Bio 2019 Apr 5;9(4):743-754. Epub 2019 Mar 5.

Department of Parasitology Institute of Biomedical Sciences University of São Paulo Brazil.

Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus . Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug-resistant strains has been observed. Therefore, new therapeutic targets against leishmaniasis are required. Read More

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http://dx.doi.org/10.1002/2211-5463.12613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443866PMC
April 2019
2 Reads

Mogamulizumab for the Treatment of Adult T-cell Leukemia/Lymphoma.

Clin Lymphoma Myeloma Leuk 2019 Mar 23. Epub 2019 Mar 23.

Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University, Saga, Japan; Department of Drug Discovery and Biomedical Sciences, Faculty of Medicine Saga University, Saga, Japan.

Mogamulizumab, a defucosylated humanized monoclonal antibody against the C-C chemokine receptor 4 (CCR4), has been approved for the treatment of relapsed adult T-cell leukemia/lymphoma (ATL). Compared with conventional chemotherapy, mogamulizumab monotherapy displayed more efficacy in relapsed ATL, making mogamulizumab a promising therapeutic agent. However, mogamulizumab could increase graft-versus-host disease, resulting in poor survival outcome in the allogenic stem cell transplant (allo-SCT) setting. Read More

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http://dx.doi.org/10.1016/j.clml.2019.03.004DOI Listing
March 2019
1 Read

Treatment of a Malignant Soft Tissue Tumor Arising in the Vicinity of the Sciatic Nerve with an In-Situ Preparation Technique and Intensive Multidisciplinary Therapy.

Cancers (Basel) 2019 Apr 10;11(4). Epub 2019 Apr 10.

Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.

Preservation of the sciatic nerve is difficult in cases of highly malignant soft tissuetumors closely surrounding the nerve. Herein, we present the first case of preservation of thisnerve by combining an in-situ preparation technique (ISP; a technique enabling the preparation ofneurovascular bundles without contamination by tumor cells) with intensive concurrent neoadjuvantchemo-radiotherapy with hyperthermia (RHC; radio-hyperthermo-chemotherapy). A 62-year-oldman presented with a soft tissue mass in the right thigh and was diagnosed with undifferentiatedpleomorphic sarcoma. Read More

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http://dx.doi.org/10.3390/cancers11040506DOI Listing

Impact of Total Antithrombotic Effect on Bleeding Complications in Patients Receiving Multiple Antithrombotic Agents.

Circ J 2019 Apr 11. Epub 2019 Apr 11.

Division of Cardiology, Yokohama City University Medical Center.

Background: Few reports have evaluated the total antithrombotic effect of multiple antithrombotic agents. Methods and Results: Thrombus formation was evaluated with the Total Thrombus-formation Analysis System (T-TAS) using 2 types of microchips in 145 patients with stable coronary artery disease receiving oral anticoagulants plus single- or dual-antiplatelet therapy. The PL-chip coated with collagen is designed for analysis of the platelet thrombus formation process under shear stress condition (18 µL/min). Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1236DOI Listing
April 2019
1 Read

Novel regulatory systems for acetylcholine release in rat striatum and anti-Alzheimer's disease drugs.

J Neurochem 2019 Apr 10. Epub 2019 Apr 10.

Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.

Regulation of neurotransmitter release in the central nervous system is complex. Here, we investigated regulatory mechanisms for acetylcholine (ACh) release from cholinergic neurons by performing superfusion experiments with rat striatal segments after labelling the cellular ACh pool with [ H]choline. Electrical stimulation evoked pronounced [ H]ACh release from cholinergic neurons. Read More

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http://dx.doi.org/10.1111/jnc.14701DOI Listing
April 2019
1 Read

De-escalated neoadjuvant therapy with nanoparticle albumin-bound paclitaxel and trastuzumab for low-risk pure HER2 breast cancer.

Cancer Chemother Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Department of Breast and Endocrine Surgery, Osaka Medical College Hospital, 2-7 Daigaku-machi, Takatsuki-shi, Osaka, 569-8686, Japan.

Purpose: Neoadjuvant trastuzumab combined with anthracycline and taxane is now considered a standard regimen for human epidermal growth factor receptor 2 (HER2)-positive breast cancer. A less toxic, non-anthracycline regimen has been considered as a treatment option for patients with node-negative small tumors. Estrogen receptor-negative and HER2-positive (pure HER2) tumors are more likely to achieve a pathological complete response (pCR). Read More

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http://dx.doi.org/10.1007/s00280-019-03836-zDOI Listing
April 2019
1 Read

Angiolymphoid Hyperplasia with Eosinophilia Successfully Treated with Cryotherapy.

Open Access Maced J Med Sci 2019 Mar 14;7(5):794-796. Epub 2019 Mar 14.

Clinic of Dermatology, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Angiolymphoid hyperplasia with eosinophilia is an uncommon, benign, vasoproliferative cutaneous neoplasm with uncertain origin. It preferably affects middle-aged adults, manifesting as plum-colored pruritic papules, nodules and plaques, which can persist indefinitely, relapsing over time. Different response/resistance to various therapeutic modalities and frequent recurrences impose a great therapeutic dilemma. Read More

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http://dx.doi.org/10.3889/oamjms.2019.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447327PMC
March 2019
1 Read

Performance of the COPD Assessment Test in patients with connective tissue disease-associated interstitial lung disease.

Respir Med 2019 Apr 1;150:15-20. Epub 2019 Feb 1.

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. Electronic address:

Background: Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) often experience impaired health status. In daily clinical practice, a short and easy instrument for assessing health status would be useful to help better understand the patient's condition. The COPD Assessment Test (CAT) is a simple questionnaire about respiratory symptoms and their impact. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.01.017DOI Listing
April 2019
3 Reads

Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection.

PLoS Pathog 2019 Apr 8;15(4):e1007674. Epub 2019 Apr 8.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.

Viral myocarditis is a serious disease, commonly caused by type B coxsackieviruses (CVB). Here we show that innate immune protection against CVB3 myocarditis requires the IFIT (IFN-induced with tetratricopeptide) locus, which acts in a biphasic manner. Using IFIT locus knockout (IFITKO) cardiomyocytes we show that, in the absence of the IFIT locus, viral replication is dramatically increased, indicating that constitutive IFIT expression suppresses CVB replication in this cell type. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453442PMC
April 2019
3 Reads

Demographics and clinical characteristics associated with sustained remission and continuation of sustained remission in patients with rheumatoid arthritis treated with adalimumab.

Inflamm Regen 2019 25;39. Epub 2019 Mar 25.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, 160-8582 Japan.

Background: Tumor necrosis factor inhibitor therapy for rheumatoid arthritis (RA) patients reduces disease activity, but little is known about the factors that correlate with continuation of remission. To identify demographics and clinical characteristics associated with achievement and continuation of sustained remission in patients with rheumatoid arthritis treated with adalimumab (ADA).

Methods: In this retrospective cohort study, clinical outcome was retrospectively evaluated in RA patients that received ADA at a single institution using 28-joint disease activity score with erythrocyte sedimentation rate (DAS28-ESR). Read More

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http://dx.doi.org/10.1186/s41232-019-0094-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432758PMC

Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model.

Biochem Biophys Res Commun 2019 Apr 4. Epub 2019 Apr 4.

AntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USA. Electronic address:

Recurrent osteosarcoma is a chemotherapy-resistant disease. Individualized precision therapy is needed for this disease. Toward this goal, we have developed the patient-derived othotopic xenograft (PDOX) mouse model of all major cancer types including osteosarcoma. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.191DOI Listing
April 2019
2 Reads

Deep palmar tumorous conditions of the hand.

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019840736

2 Hand Microsurgery Orthopaedics and Traumatology (EMOT) Hospital, Izmir, Turkey.

Purpose:: Deep palmar tumors of the hand are very rare, and reported cases are usually benign. The most important issue is frequent anatomical variations with challenging surgical exposure and excision of these lesions. Some case reports or a small series of patients have been reported in the literature. Read More

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http://journals.sagepub.com/doi/10.1177/2309499019840736
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http://dx.doi.org/10.1177/2309499019840736DOI Listing
April 2019
2 Reads

A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques.

Nat Biomed Eng 2019 Mar 11;3(3):206-219. Epub 2019 Feb 11.

Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan.

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that lack therapeutic solutions. Here, we show that the molecular chaperone (N,N'-([cyclohexylmethylene]di-4,1-phenylene)bis(2-[1-pyrrolidinyl]acetamide)), designed via docking simulations, molecular dynamics simulations and quantum chemical calculations, slows down the progress of TSEs. In vitro, the designer molecular chaperone stabilizes the normal cellular prion protein, eradicates prions in infected cells, prevents the formation of drug-resistant strains and directly inhibits the interaction between prions and abnormal aggregates, as shown via real-time quaking-induced conversion and in vitro conversion NMR. Read More

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http://dx.doi.org/10.1038/s41551-019-0349-8DOI Listing
March 2019
1 Read

[TNF-α Decreased Corticosteroid Responsiveness in Mice Models of Airway Inflammation Induced by Double Strand RNA and/or Tobacco Smoke Exposure].

Yakugaku Zasshi 2019 Apr 2. Epub 2019 Apr 2.

Laboratory of Physiology and Anatomy, School of Pharmacy, Nihon University.

Reduction of corticosteroid responsiveness is one of the important clinical problems in chronic obstructive pulmonary disease (COPD). In this study, we determined the effects of neutralization of tumor necrosis factor-α (TNF-α) on corticosteroid insensitivity in mice models of airway inflammation induced by poly(I:C) and tobacco smoke (TS) exposure. Mice (male A/J strain, 5 weeks old) were exposed to TS for 10 days, or TS for 11 days and poly(I:C) for 3 days. Read More

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https://www.jstage.jst.go.jp/article/yakushi/advpub/0/advpub
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http://dx.doi.org/10.1248/yakushi.18-00230DOI Listing
April 2019
3 Reads

Inhibition of the Mammalian Target of Rapamycin May Augment the Increase in Soluble Klotho Levels in Renal Transplantation Recipients.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan.

Background/aims: α-Klotho is mainly expressed in the kidneys, and its soluble form can prevent vascular calcifications. Inhibition of the mammalian target of rapamycin (mTOR) upregulates Klotho. We assessed serial changes in the levels of soluble Klotho (sKlotho) in recipients before and after renal transplantation and investigated the effects of an mTOR inhibitor. Read More

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http://dx.doi.org/10.1159/000496630DOI Listing
April 2019
3 Reads

Does right-sided varicocele indicate a right-sided kidney tumor?

Arch Ital Urol Androl 2019 Mar 29;91(1):53-54. Epub 2019 Mar 29.

Urology, Hospital de Base de São José do Rio Preto/Famerp/Funfarme.

Varicocele is a dilation of the pampiniform venous plexus, mainly affecting the left side of the scrotum. In rare cases, however, the right side is affected. When this occurs, a retroperitoneal disease should be suspected, such as right-sided renal neoplasm. Read More

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http://dx.doi.org/10.4081/aiua.2019.1.53DOI Listing
March 2019
1 Read

Admission Heart Rate Is a Determinant of Effectiveness of Beta-Blockers in Acute Myocardial Infarction Patients.

Circ J 2019 Mar 30. Epub 2019 Mar 30.

Division of Coronary Artery Disease, Hyogo College of Medicine.

Background: Beta-blockers are standard therapy for acute myocardial infarction (AMI). However, despite current advances in the management of AMI, it remains unclear whether all AMI patients benefit from β-blockers. We investigated whether admission heart rate (HR) is a determinant of the effectiveness of β-blockers for AMI patients. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-0995DOI Listing
March 2019
1 Read

Risk Factors for Acute Heart Failure and Impact on In-Hospital Mortality after Stroke.

J Stroke Cerebrovasc Dis 2019 Mar 28. Epub 2019 Mar 28.

Department of Neuroendovascular Therapy, St. Luke's International Hospital, Tokyo, Japan.

Background: In the acute phase of stroke, some patients develop cardiac events. It could be fatal in their clinical courses. We aimed to investigate acute heart failure after stroke onset and stratify the patients by establishing a predictive model. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.030DOI Listing
March 2019
3 Reads

A novel combination of prion strain co-occurrence in patients with sporadic Creutzfeldt-Jakob disease.

Am J Pathol 2019 Mar 26. Epub 2019 Mar 26.

Department of Neurological Science, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

Six subgroups of sporadic Creutzfeldt-Jakob disease have been identified by distinctive clinicopathological features, genotype at polymorphic codon 129 (methionine/valine, M/V) of the PRNP gene, and type of abnormal prion proteins (type 1 or 2). In addition to the pure subgroups, mixed neuropathological features and co-existence of two types of abnormal prion proteins in the same patient have also been reported. Here, we found that a portion of the patients previously diagnosed as MM1 had neuropathological characteristics of MM2 thalamic form, ie, neuronal loss of the inferior olivary nucleus of the medulla. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.02.012DOI Listing
March 2019
1 Read

Treatment and clinical outcome of clinical T4 esophageal cancer: A systematic review.

Ann Gastroenterol Surg 2019 Mar 13;3(2):169-180. Epub 2018 Dec 13.

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Osaka Japan.

Background: Survival of patients with cT4 esophageal cancer is dismal. Although the optimal treatment strategy remains to be established, two treatment options are available for cT4 esophageal cancers: definitive chemoradiation (dCRT) and induction treatment followed by conversion surgery (CS). However, little is known concerning the differences in clinical outcome between patients with T4 esophageal tumors treated with dCRT and those eventually treated with CS. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ags3.12222
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http://dx.doi.org/10.1002/ags3.12222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422802PMC
March 2019
3 Reads

Aortic Plaque Distribution, and Association between Aortic Plaque and Atherosclerotic Risk Factors: An Aortic Angioscopy Study.

J Atheroscler Thromb 2019 Mar 27. Epub 2019 Mar 27.

Cardiovascular Center, Yokosuka Kyosai Hospital.

Aim: Knowledge of subclinical plaque morphology and plaque distribution in the aorta in vivo remains unclear. This study aimed to increase the body of knowledge in this area.

Methods: We enrolled 37 consecutive patients with stable angina pectoris patients who underwent non-obstructive angioscopy for both the coronary artery and aorta immediately after percutaneous coronary intervention. Read More

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http://dx.doi.org/10.5551/jat.48181DOI Listing
March 2019
1 Read

[A Case of Primary Small Cell Carcinoma in the Breast with Neoadjuvant Chemotherapy That Were Difficult to Select Chemotherapy].

Gan To Kagaku Ryoho 2019 Feb;46(2):263-266

Dept. of Surgery, Hiroshima City Asa Citizens Hospital.

Primary small cell carcinoma in the breast is a rare and aggressive tumor, and a standard treatment strategy has not been established. Herein, we report a 35-year-old woman with primary small cell carcinoma in the breast. She had an 8 cm diameter tumor in the right breast. Read More

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February 2019
1 Read

Angiolymphoid hyperplasia with eosinophilia in a hand treated with a reverse digital island flap and artificial skin: a case report.

J Med Case Rep 2019 Mar 27;13(1):87. Epub 2019 Mar 27.

Department of Orthopedic Surgery, Kindai University Hospital, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Background: Angiolymphoid hyperplasia with eosinophilia is a rare nodular skin tumor characterized by eosinophilic invasion and vascular proliferation. Previous reports suggested that irritation and inflammation are the causative factors of this disease. Most cases of angiolymphoid hyperplasia with eosinophilia occur around the auricle, forehead, and scalp; the hand is rarely affected. Read More

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http://dx.doi.org/10.1186/s13256-019-2021-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436222PMC
March 2019
1 Read

Kimura's disease with membranoproliferative glomerulonephritis: a case report with literature review.

Ren Fail 2019 Nov;41(1):126-130

a Department of Nephrology , the First Hospital of Jilin University , Changchun , China.

Background: Kimura's disease is a rare disease and its etiology is still unclear. Here we reported a case with lymphadenopathy complicated with secondary membranoproliferative glomerulonephritis.

Case Presentation: A 46-year-old Chinese man presented with bilateral tumor-like nodules over his neck during the past 6 months and developed edema for 15 days. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1584115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442089PMC
November 2019
1 Read

-Serine reflects kidney function and diseases.

Sci Rep 2019 Mar 25;9(1):5104. Epub 2019 Mar 25.

KAGAMI Project, National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan.

-Amino acids, long-term undetected enantiomers of -amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early detection of diseases. We now show that intra-body dynamics of -serine reflect kidney function and diseases. Read More

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http://dx.doi.org/10.1038/s41598-019-41608-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434045PMC
March 2019
1 Read

Clinical impact of extended blood culture examination: Too much of a good thing.

J Infect Chemother 2019 Mar 20. Epub 2019 Mar 20.

Division of Infection Control and Prevention, Osaka University Hospital, Osaka, Japan.

Blood culture is the most critical examination for diagnosing bacterial infections. The longer the blood culture incubation period, the higher the chances of identifying bacterial strains. However, unnecessary extension of the incubation period can burden the capacity of the instrument and merely result in the detection of contaminant bacteria having no clinical significance. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.03.001DOI Listing

Focal Neuroendocrine Differentiation of Conventional Prostate Adenocarcinoma as a Prognostic Factor after Radical Prostatectomy: A Systematic Review and Meta-Analysis.

Int J Mol Sci 2019 Mar 19;20(6). Epub 2019 Mar 19.

Institute for Urology and Reproductive Health, Sechenov University, Moscow 119991, Russia.

The biologic and prognostic value of focal neuroendocrine differentiation (NED) in conventional prostate adenocarcinoma (PC) patients who undergo radical prostatectomy (RP) remains controversial. In this systematic review and meta-analysis, we assessed the association of focal NED in conventional PC with oncological outcomes after RP. A literature search using PubMed, Scopus, Web of Science, and Cochrane Library was conducted on December 2018 to find relevant studies according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Read More

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http://dx.doi.org/10.3390/ijms20061374DOI Listing
March 2019
2.862 Impact Factor

Monomeric α-synuclein induces blood-brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro.

Microvasc Res 2019 07 15;124:61-66. Epub 2019 Mar 15.

Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan. Electronic address:

Blood-brain barrier (BBB) disruption is often mediated by neuroinflammation, and occurs during various neurodegenerative diseases including Parkinson's disease (PD). PD is characterized by loss of dopaminergic neurons and aggregated α-synuclein protein in inclusions known as Lewy bodies. Misfolded α-synuclein has been implicated in neurodegeneration and neuroinflammation through activation of microglia and astrocytes. Read More

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http://dx.doi.org/10.1016/j.mvr.2019.03.005DOI Listing
July 2019
2 Reads

Angiolymphoid hyperplasia with eosinophilia of the external ear.

Am J Otolaryngol 2019 Mar 12. Epub 2019 Mar 12.

Icahn School of Medicine at Mount Sinai, Department of Otolaryngology-Head and Neck Surgery, USA; New York Eye and Ear Infirmary of Mount Sinai, Department of Otolaryngology, USA; Audiology, Hearing, and Balance Center, Mount Sinai Health System, USA; Ear Institute, Mount Sinai Health System, USA.

Herein we present the rare case of angiolymphoid hyperplasia with eosinophilia of the external ear treated by surgical resection and full-thickness skin graft. Current diagnosis and management options are reviewed. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.03.007DOI Listing

A Case of Bilateral Spontaneous Chylothorax with Respiratory Syncytial Virus Bronchiolitis.

Case Rep Pediatr 2019 6;2019:2853632. Epub 2019 Feb 6.

Division of Critical Care Medicine, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TN, USA.

A case of bilateral spontaneous chylothorax with respiratory syncytial virus (RSV) bronchiolitis has never been reported. We report the case of a 7-month-old boy born at 33 weeks gestation with a history of Down syndrome, atrial septal defect, pulmonary hypertension, and chronic lung disease, hospitalized due to RSV bronchiolitis who developed bilateral spontaneous chylothorax with exacerbation of pulmonary hypertension (PH). The patient died after 9 weeks of mechanical ventilation and treatment for PH. Read More

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http://dx.doi.org/10.1155/2019/2853632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381583PMC
February 2019
1 Read

Rendezvous Technique Using Double Balloon Endoscope for Removal of Multiple Intrahepatic Bile Duct Stones in Hepaticojejunostomy After Living Donor Liver Transplant: A Case Report.

Transplant Proc 2019 Mar 12;51(2):579-584. Epub 2018 Dec 12.

Department of Endoscopy and Endoscopic Surgery, Fukuoka Dental College, Fukuoka, Japan; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Cholangitis is a major complication following transplantation. We report a living donor liver transplant (LDLT) patient with cholangitis due to multiple stones in the intrahepatic bile duct during hepaticojejunostomy anastomosis, who was successfully treated with the rendezvous technique using double balloon endoscope. A 64-year-old woman underwent LDLT with right lobe graft and hepaticojejunostomy for Wilson disease. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.005DOI Listing
March 2019
2 Reads

Effects of Sarilumab on Patient-Reported Impact of Rheumatoid Arthritis Using the Rheumatoid Arthritis Impact of Disease Scale.

J Rheumatol 2019 Mar 15. Epub 2019 Mar 15.

From the Sorbonne Université and Rheumatology Department, Hôpital; Stanford University; Novartis; Regeneron Pharmaceuticals, Inc and Sanofi. L. Gossec has acted as a consultant for Abbvie, BMS, Celgene, Janssen, Lilly, Novartis, MSD, Pfizer, Roche, Sanofi and UCB. V. Strand has acted as a consultant for AbbVie, Amgen, AstraZeneca, Biogen, BMS, Celgene, Celltrion, Consortium of Rheumatology Researchers of North America (CORRONA), Crescendo/Myriad Genetics, Genentech/Roche, GSK, Janssen, Eli Lilly, Novartis, Pfizer Inc., Regeneron Pharmaceuticals, Inc., Sandoz, Sanofi, and UCB. C. Proudfoot is a former employee of and current shareholder in Sanofi and current employee and shareholder of ViiV Healthcare/GlaxoSmithKline. C. Chen, T. Kimura, and E. Mangan are employees of and shareholders in Regeneron Pharmaceuticals, Inc. E. Mangan is also a shareholder in Pfizer. S. Guillonneau, H. van Hoogstraten, and M. Reaney are employees of and hold shares or options in Sanofi. Address correspondence to Matthew Reaney, Sanofi, One Onslow Street, Guildford, Surrey, GU1 4YS, UK. E-mail:

Objective: The impact of rheumatoid arthritis (RA) symptoms on patients' lives is significant. This study evaluated the effect of sarilumab on patient-perceived impact of RA using the 7-domain RA Impact of Disease (RAID) scale.

Methods: Two phase III, randomized, controlled trials of sarilumab in patients with active, long-standing RA were analyzed: sarilumab 150 mg and 200 mg twice-weekly plus conventional synthetic disease-modifying antirheumatic drugs (+csDMARDs) versus placebo+csDMARDs [TARGET (NCT01709578)]; sarilumab 200 mg versus adalimumab 40 mg monotherapy (MONARCH [NCT02332590]). Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180904
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http://dx.doi.org/10.3899/jrheum.180904DOI Listing
March 2019
10 Reads

Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia.

Atherosclerosis 2019 Feb 28;284:18-23. Epub 2019 Feb 28.

Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Background And Aims: The development of serum markers specific for coronary lesions is important to prevent coronary events. However, analyses of serum markers in humans are affected by environmental factors and non-target diseases. Using an appropriate model animal can reduce these effects. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.020DOI Listing
February 2019
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Differences in Awareness of Disease Between Young-onset and Late-onset Dementia.

Alzheimer Dis Assoc Disord 2019 Mar 12. Epub 2019 Mar 12.

Center for Alzheimer's disease and Related Disorders, Institute of Psychiatry, Universidade Federal do Rio de Janeiro.

Introduction: Awareness of disease is the ability to acknowledge changes caused by deficits related to the disease process. We aimed to investigate whether there are differences in awareness of disease between young-onset dementia (YOD) and late-onset dementia (LOD) and examined how awareness interacts with cognitive and clinical variables.

Materials And Methods: Using a cross-sectional design, 49 people with YOD and 83 with LOD and their caregivers were included. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000299DOI Listing
March 2019
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Neoadjuvant Chemotherapy with Gemcitabine Plus Nab-Paclitaxel for Borderline Resectable Pancreatic Cancer Potentially Improves Survival and Facilitates Surgery.

Ann Surg Oncol 2019 May 13;26(5):1528-1534. Epub 2019 Mar 13.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Accumulation of evidence suggests that neoadjuvant chemotherapy improves the outcomes of borderline resectable pancreatic cancer (BRPC). Gemcitabine plus nab-paclitaxel (GnP) has been widely accepted as systemic chemotherapy for unresectable pancreatic cancer and reportedly results in remarkable tumor shrinkage. This study was performed to evaluate the safety and efficacy of neoadjuvant chemotherapy using neoadjuvant GnP for BRPC. Read More

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http://dx.doi.org/10.1245/s10434-019-07309-8DOI Listing
May 2019
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Duplication of F1245 missense mutation due to acquired uniparental disomy associated with aggressive progression in a patient with relapsed neuroblastoma.

Oncol Lett 2019 Mar 29;17(3):3323-3329. Epub 2019 Jan 29.

Department of Pediatrics, St Luke's International Hospital, Tokyo 104-8560, Japan.

Recent genome-wide analysis of neuroblastoma (NBL) revealed amplification and heterozygous mutation of are responsible for oncogenicity, frequently observed during relapses. A 3-year-old girl with relapsed high-risk NBL had a heterozygous F1245L mutation at diagnosis, which became homozygous due to uniparental disomy (UPD) of the entire chromosome 2, confirmed by single nucleotide polymorphism array and variant allele frequency of this mutation. The ALK inhibitor, crizotinib, failed to control the tumor and the patient died of the disease. Read More

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http://dx.doi.org/10.3892/ol.2019.9985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396392PMC
March 2019
3 Reads

Increase of arginine dimethylation correlates with the progression and prognosis of ALS.

Neurology 2019 Apr 13;92(16):e1868-e1877. Epub 2019 Mar 13.

From the Department of Neurology (K.I., N.A., R.N., K. Kawai, D.Y., M.K., G.S.), Nagoya University Graduate School of Medicine; Department of Neurology (K.I., H.M.), Osaka University Graduate School of Medicine, Suita; Department of Hospital Pharmacy (Y.M., Y.H., K. Kimura), Nagoya City University Graduate School of Pharmaceutical Sciences; Department of Biostatistics and Bioinformatics (A.H.), University of Tokyo; Department of Neurology (A.T.), Mie University Graduate School of Medicine, Tsu; Department of Neurology (M.M.), Jichi Medical University, Shimotsuke, Tochigi; National Hospital Organization, Shizuoka Medical Center (K.M.); and Brain and Mind Research Center (G.S.), Nagoya University, Aichi, Japan.

Objective: To investigate whether arginine methylation is altered in patients with amyotrophic lateral sclerosis (ALS) and how it affects disease severity, progression, and prognosis.

Methods: We compared the immunoreactivity of protein arginine methyltransferase 1 (PRMT1) and its products, asymmetric dimethylated proteins (ASYM), in postmortem spinal cord. We also measured the concentrations of total l-arginine and methylated arginine residues, including asymmetric dimethyl l-arginine (ADMA), symmetric dimethyl arginine, and monomethyl arginine, in CSF samples from 52 patients with ALS using liquid chromatography-tandem mass spectrometry, and we examined their relationship with the progression and prognosis of ALS. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007311DOI Listing
April 2019
17 Reads

Nivolumab-induced interstitial lung disease in a patient with gastric cancer.

Oxf Med Case Reports 2019 Feb 27;2019(2):omz007. Epub 2019 Feb 27.

Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, E21-19, 2-2, Yamadaoka, Suita, Osaka, Japan.

We herein report a case of nivolumab-induced interstitial lung disease in a patient with gastric cancer. Nivolumab is a fully human IgG4 monoclonal antibody inhibitor of programmed death-1. A 69-year-old woman with metastatic gastric cancer being treated with nivolumab as fifth-line therapy developed interstitial pneumonia 27 months after starting treatment with nivolumab. Read More

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http://dx.doi.org/10.1093/omcr/omz007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402314PMC
February 2019

Registration-directed phase 1/2 trial of irinotecan for pediatric solid tumors.

Pediatr Int 2019 Mar 11. Epub 2019 Mar 11.

Department of Pediatric Surgery, University of Tsukuba School of Medicine, Ibaraki, Japan.

Background: Although irinotecan hydrochloride (IRI) is a promising chemotherapeutic agent for pediatric solid tumors, its indications had been off-label in the US, EU or Japan. Therefore, we conducted a phase 1/2 trial of IRI monotherapy in a registration-directed setting.

Methods: Children aged 2 to 18 years with solid tumors which were either refractory to or relapsed after standard chemotherapy were enrolled. Read More

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http://dx.doi.org/10.1111/ped.13826DOI Listing
March 2019
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Association of endothelial function with thin-cap fibroatheroma as assessed by optical coherence tomography in patients with acute coronary syndromes.

Ther Clin Risk Manag 2019 15;15:285-291. Epub 2019 Feb 15.

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan,

Background: Thinning of the fibrous cap of atherosclerotic plaque is a major component of plaque vulnerability. The high resolution of optical coherence tomography (OCT) provides an accurate measurement of fibrous-cap thickness. Endothelial dysfunction is associated with inflammation and enhanced local expression of matrix metalloproteinases. Read More

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https://www.dovepress.com/association-of-endothelial-functio
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http://dx.doi.org/10.2147/TCRM.S184457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385782PMC
February 2019
4 Reads

TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys.

PLoS One 2019 11;14(3):e0207969. Epub 2019 Mar 11.

Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.

Activation of the muscarinic M1 receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer's disease, dementia with Lewy bodies, and schizophrenia. TAK-071 is an M1-selective positive allosteric modulator that improves cognitive deficits induced by scopolamine, a non-selective muscarinic receptor antagonist, with reduced side effects on gastrointestinal function in rats. In this study, we explored changes in quantitative electroencephalography (qEEG) power bands, with or without scopolamine challenge, as a non-invasive translational biomarker for the effect of TAK-071 in cynomolgus monkeys. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207969PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411103PMC
March 2019
1 Read

The impact of gender on oncologic outcomes of bladder cancer.

Curr Opin Urol 2019 May;29(3):279-285

Department of Urology, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: The purpose of this article is to review the current literature on the impact of gender on oncologic outcomes of bladder cancer (BCa).

Recent Findings: Women are more likely to experience disease recurrence, progression, and/or death across all disease states. Furthermore, women are less likely to respond to intravesical therapy for nonmuscle invasive BCa. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000606DOI Listing
May 2019
1 Read