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    Foodborne Outbreaks Caused by Human Norovirus GII.P17-GII.17-Contaminated Nori, Japan, 2017.
    Emerg Infect Dis 2018 May;24(5):920-923
    Seven foodborne norovirus outbreaks attributable to the GII.P17-GII.17 strain were reported across Japan in 2017, causing illness in a total of 2,094 persons. Read More

    Sequential histological findings and clinical response after carbon ion radiotherapy for unresectable sarcoma.
    Clin Transl Radiat Oncol 2017 Feb 6;2:41-45. Epub 2017 Feb 6.
    Department of Orthopaedics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
    Background And Purpose: The efficacy of carbon ion radiotherapy (CIRT) for bone and soft tissue sarcoma has been reported recently. Although histological assessment after CIRT requires skilled interpretation, little information is presently available. In this study, we report sequential histological findings after treatment with CIRT, and evaluate the association between these findings and clinical response. Read More

    Preoperative evaluation of the efficacy of radio-hyperthermo-chemotherapy for soft tissue sarcoma in a case series.
    PLoS One 2018 16;13(4):e0195289. Epub 2018 Apr 16.
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
    Purpose: Radio-hyperthermo-chemo (RHC) therapy, which combines radiotherapy, hyperthermia, and chemotherapy, for malignant soft tissue tumors has been introduced with the aim of decreasing the possibility of local recurrence after surgery. To avoid unnecessary neoadjuvant therapy and to plan the appropriate surgical treatment, surveillance of RHC therapeutic efficacy during treatment is necessary. In this study, we determined the optimal response criteria to evaluate the efficacy of RHC by comparing preoperative images before and after RHC with pathological evaluation of necrosis in the resected tumor. Read More

    Does interferon-free direct-acting antiviral therapy for hepatitis C after curative treatment for hepatocellular carcinoma lead to unexpected recurrences of HCC? A multicenter study by the Japanese Red Cross Hospital Liver Study Group.
    PLoS One 2018 16;13(4):e0194704. Epub 2018 Apr 16.
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.
    Background And Aim: This study aimed to elucidate whether interferon (IFN)-free direct-acting antiviral (DAA) therapy for hepatitis C after curative treatment of hepatocellular carcinoma (HCC) promotes HCC recurrence in a real-world large-scale cohort.

    Methods: This multicenter study was conducted by the Japanese Red Cross Hospital Liver Study Group. This retrospective study analyzed 516 patients who underwent antiviral treatment for hepatitis C with either IFN (n = 148) or IFN-free DAA (n = 368) after curative HCC treatment; 78 IFN-treated patients and 347 IFN-free DAA-treated patients achieved sustained virological response (SVR). Read More

    Caregivers' Perspectives of Quality of Life of People With Young- and Late-Onset Alzheimer Disease.
    J Geriatr Psychiatry Neurol 2018 Mar;31(2):76-83
    1 Center for Alzheimer's Disease and Related Disorders, Institute of Psychiatry, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
    Background: Quality of life (QoL) is a growing area of interest in dementia research. This study aims to investigate the caregivers' perspective about the QoL of people with young-onset Alzheimer disease (YOAD) and late-onset Alzheimer disease (LOAD). We also aim to investigate factors that might be associated to caregivers' perspective in YOAD and LOAD. Read More

    Detailed Imaging Findings in a Rare Case of Kimura Disease, with Special Mention on Diffusion Weighted Imaging.
    Pol J Radiol 2017 20;82:607-611. Epub 2017 Oct 20.
    Department of Radiodiagnosis, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Poona, Maharashtra, India.
    Background: Kimura disease is an uncommon, benign, chronic, idiopathic disease that is seen mainly in the Asian population, particularly in females. It mainly affects the salivary glands and in particular parotid and cervical lymph nodes. So far, the diagnosis of Kimura disease has been based on histopathology. Read More

    Non-invasive testing for sarcopenia predicts future cardiovascular events in patients with chronic kidney disease.
    Int J Cardiol 2018 Apr 5. Epub 2018 Apr 5.
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
    Background: Sarcopenia is frequently observed and associated with poor outcomes in patients with chronic kidney disease (CKD). A simple screening test for sarcopenia using age, grip strength, and calf circumference was recently developed. However, the clinical utility of this sarcopenia score in patients with CKD remains unclear. Read More

    Transfer coefficients (Kco) better reflect emphysematous changes than carbon monoxide diffusing capacity (DLco) in obstructive lung diseases.
    J Appl Physiol (1985) 2018 Apr 12. Epub 2018 Apr 12.
    Hokkaido University School of Medicine, Japan.
    The overlap between asthma and chronic obstructive pulmonary disease (COPD) has attracted the interest of pulmonary physicians; thus, measurement of carbon monoxide diffusion capacity (DLco) and/or transfer coefficients (Kco, DLco/VA) may become valuable in clinical settings. How these parameters behave in chronic obstructive lung diseases is poorly understood. We predicted that Kco might more accurately reflect emphysematous changes in the lungs, than DLco. Read More

    Adding patient-reported outcomes to a multisite registry to quantify quality of life and experiences of disease and treatment for youth with juvenile idiopathic arthritis.
    J Patient Rep Outcomes 2018 4;2. Epub 2018 Jan 4.
    Department of Pediatrics, Harvard Medical School, Boston 02115, USA.
    Background: Children with Juvenile Idiopathic Arthritis (JIA) often have poor health-related quality of life (HRQOL) despite advances in treatment. Patient-centered research may shed light on how patient experiences of treatment and disease contribute to HRQOL, pinpointing directions for improving care and enhancing outcomes.

    Methods: Parent proxies of youth enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry shared patient-reported outcomes about their child's HRQOL and experiences of disease and treatment burden (pain interference, morning stiffness, history of medication side effects and methotrexate intolerance). Read More

    Molecular diversity of the faecal microbiota of Toy Poodles in Japan.
    J Vet Med Sci 2018 Apr 11. Epub 2018 Apr 11.
    Research and Education Center for Prevention of Global Infectious Disease of Animals, Faculty of Agriculture, Tokyo University of Agriculture and Technology.
    The intestinal microbiota was revealed with the recent advances in molecular techniques, such as high-throughput sequencing analysis. As a result, the microbial changes are thought to influence the health of humans and animals and such changes are affected by several factors including diet, genetics, age, sex, and diseases. Similar studies are being conducted in dogs, and the knowledge of intestinal microbiota in dogs is expanding. Read More

    New World feline APOBEC3 potently controls inter-genus lentiviral transmission.
    Retrovirology 2018 Apr 10;15(1):31. Epub 2018 Apr 10.
    Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
    Background: The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; A3) gene family appears only in mammalian genomes. Some A3 proteins can be incorporated into progeny virions and inhibit lentiviral replication. In turn, the lentiviral viral infectivity factor (Vif) counteracts the A3-mediated antiviral effect by degrading A3 proteins. Read More

    A case of complete splenic infarction after laparoscopic spleen-preserving distal pancreatectomy.
    BMC Surg 2018 Apr 10;18(1):22. Epub 2018 Apr 10.
    Department of Surgical Oncology, Osaka City University School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
    Background: Laparoscopic spleen-preserving distal pancreatectomy (LSPDP), a newly developed operative procedure, is indicated for benign and low-grade malignant disease of the pancreas. However, few studies have reported on postoperative splenic infarction after LSPDP.

    Case Presentation: We report a case of complete splenic infarction and obliteration of the splenic artery and vein after LSPDP. Read More

    Eosinophilia in the muscle layer of the esophagus and the urinary bladder in a Multiple System Atrophy patient with dysphagia and dysuria.
    Pathol Int 2018 Apr 6. Epub 2018 Apr 6.
    Department of Diagnostic Pathology, Steel Memorial Hirohata Hospital, Himeji, Hyogo, Japan.
    Multiple system atrophy (MSA) is a spinocerebellar degenerative disease characterized by cerebellar ataxia, parkinsonism, and autonomic failure. A 75-year-old woman who had suffered from dysphagia and dysuria under a diagnosis of probable MSA with predominant cerebellar ataxia underwent autopsy. Eosinophilia was seen extensively in the muscle layer of the esophagus and urinary bladder. Read More

    Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fibrosis.
    World J Gastroenterol 2018 Apr;24(13):1440-1450
    Department of Internal Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
    Aim: The impact of mild drinking habit (less than 20 g/d of ethanol) on the clinical course of non-alcoholic fatty liver disease (NAFLD) has not been determined. We examined the influence of a mild drinking habit on liver carcinogenesis from NAFLD.

    Methods: A total of 301 patients who had been diagnosed as having NAFLD by liver biopsy between 2003 and 2016 [median age: 56 years, 45% male, 56% with non-alcoholic steatohepatitis, 26% with advanced fibrosis (F3-4)] were divided into the mild drinking group with ethanol consumption of less than 20 g/d (mild drinking group, = 93) and the non-drinking group ( = 208). Read More

    [Cerebellar Ataxia and Autoantibodies].
    Brain Nerve 2018 Apr;70(4):371-382
    Tokyo Medical University Hachioji Medical Center, Department of Neurology, Tokyo Medical University Hachioji Medical Center.
    The cerebellum is one of the main targets in the central nervous system for autoimmunity. Immune-mediated cerebellar ataxias include gluten ataxia, GAD antibody-associated cerebellar ataxia, Hashimoto's encephalopathy, and paraneoplastic cerebellar degeneration. Autoimmune cerebellar ataxia may be of either insidious or subacute onset, and vertigo or transient neurological symptoms occur in some patients before the onset of the disease, in contrast to spinocerebellar degeneration. Read More

    A Rare Case of Rush Progression of Purulent Pericarditis by Escherichia coli in a Patient with Malignant Lymphoma.
    Int Heart J 2018 Apr 6. Epub 2018 Apr 6.
    Department of Cardiology, National Defense Medical College.
    Purulent pericarditis is a rare disease in the antibiotic era. The common pathogens of purulent pericarditis are gram-positive species such as Staphylococcus aureus. Streptococcus pneumoniae, Salmonella, Haemophilus, fungal pathogens/tuberculosis can also result in purulent pericarditis. Read More

    An outbreak of fluoroquinolone-resistant Pseudomonas aeruginosa ST357 harboring the exoU gene.
    J Infect Chemother 2018 Apr 5. Epub 2018 Apr 5.
    Department of Anesthesiology, School of Medicine, Japan. Electronic address:
    Antimicrobial-resistant isolates of Pseudomonas aeruginosa collected from 2005 to 2014 in a university hospital in Kyoto, Japan, were retrospectively analyzed by multilocus sequence typing (MLST), exoenzyme genotype determination, integron characterization, and clinical associations. During the study, 1573 P. aeruginosa isolates were detected, and 41 of these were resistant to more than two classes of antimicrobial agents. Read More

    Inorganic phosphorus (Pi) in CSF is a biomarker for SLC20A2-associated idiopathic basal ganglia calcification (IBGC1).
    J Neurol Sci 2018 May 8;388:150-154. Epub 2018 Mar 8.
    Department of Informative Clinical Medicine, Gifu University, Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
    Introduction: Idiopathic basal ganglia calcification (IBGC), also called Fahr's disease or recently primary familial brain calcification (PFBC), is characterized by abnormal deposits of minerals including calcium mainly and phosphate in the brain. Mutations in SLC20A2 (IBGC1 (merged with former IBGC2 and IBGC3)), which encodes PiT-2, a phosphate transporter, is the major cause of IBGC. Recently, Slc20a2-KO mice have been showed to have elevated levels of inorganic phosphorus (Pi) in cerebrospinal fluid (CSF); however, CSF Pi levels in patients with IBGC have not been fully examined. Read More

    Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry.
    Int J Food Microbiol 2018 Jun 17;274:45-51. Epub 2018 Mar 17.
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan. Electronic address:
    Extended-spectrum cephalosporin (ESC)-resistant Salmonella in chicken meat is a significant food safety concern. We previously reported that the prevalence of ESC-resistant Salmonella in chicken meat, giblets, and processed chicken (chicken meat products) increased in Japan between 2005 and 2010, with 27.9% (17/61) of Salmonella isolated from chicken meat products in 2010 showing resistance to ESC. Read More

    Real-world efficacy and safety of ledipasvir and sofosbuvir in patients with hepatitis C virus genotype 1 infection: a nationwide multicenter study by the Japanese Red Cross Liver Study Group.
    J Gastroenterol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shi, Tokyo, 180-8610, Japan.
    Background: We aimed to describe the real-world efficacy and safety of combination therapy with ledipasvir and sofosbuvir (LDV/SOF) for chronic hepatitis C virus (HCV) genotype 1 (GT1) infection.

    Methods: This retrospective analysis of a prospective, nationwide, multicenter registry included GT1-infected patients treated with LDV/SOF for 12 weeks. We assessed the rate of sustained virological response at 12 weeks post-treatment (SVR12), incidence of adverse events, and serum markers of hepatocellular carcinoma (HCC). Read More

    The Role for Exosomal microRNAs in Disruption of Regulatory T Cell Homeostasis in Multiple Sclerosis.
    J Exp Neurosci 2018 26;12:1179069518764892. Epub 2018 Mar 26.
    Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
    Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, in which myelin and oligodendrocytes are the main targets recognized by inflammatory CD4 T cells reactive to myelin peptides. Regulatory CD4 T (Treg) cells normally keep homeostasis of the immune system by inhibiting detrimental effects of inflammatory T cells. However, Treg cells are reduced in patients with MS for unknown reason. Read More

    Imaging of Benign Neoplastic and Nonneoplastic Salivary Gland Tumors.
    Neuroimaging Clin N Am 2018 May;28(2):159-169
    Department of Radiology, University of Chicago, Pritzker School of Medicine, 5841 South Maryland Avenue, Chicago, IL 60637, USA. Electronic address:
    This article reviews the multimodality diagnostic imaging features of benign neoplastic and nonneoplastic tumors associated with the major salivary glands. Examples of neoplastic conditions that are depicted and discussed include pleomorphic adenoma, Warthin tumor, oncocytoma, peripheral nerve sheath tumors, lipoma, and hemangiomas or hemangioendotheliomas. Examples of nonneoplastic conditions that are depicted and discussed include ranulas, benign lymphoepithelial lesions, Kimura disease, and vascular malformations. Read More

    Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification: a multicenter study (JOSL CT study).
    BMC Musculoskelet Disord 2018 Apr 5;19(1):107. Epub 2018 Apr 5.
    Department of Orthopedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
    Background: In patients with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, it is well known that the thoracic ossified lesions often coexist with the cervical lesions and can cause severe myelopathy. However, the prevalence of OPLL at each level of the thoracic and lumbar spinal segments is unknown. The aims of this study were to investigate how often OPLL occurs at each level in the thoracolumbar spine in patients with a radiological diagnosis of cervical OPLL and to identify the spinal levels most likely to develop ossification. Read More

    Prediction of response to medical therapy by serum soluble (pro)renin receptor levels in Graves' disease.
    PLoS One 2018 5;13(4):e0195464. Epub 2018 Apr 5.
    Department of Medicine II, Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.
    Antithyroid drugs are generally selected as the first-line treatment for Graves' Disease (GD); however, the existence of patients showing resistance or severe side effects to these drugs is an important issue to be solved. The (pro)renin receptor [(P)RR] is a multi-functional protein that activates the tissue renin-angiotensin system and is an essential constituent of vacuolar H+-ATPase, necessary for the autophagy-lysosome pathway. (P)RR is cleaved to soluble (s)(P)RR, which reflects the status of (P)RR expression. Read More

    Adult case of acute flaccid paralysis with enterovirus D68 detected in the CSF.
    Neurol Clin Pract 2017 Oct;7(5):390-393
    Departments of Neurology (KK, T Fukushima, NK, KM), Niigata Prefectural Shibata Hospital, Shibata; Department of Virology II (HS, TN), National Institute of Infectious Diseases, Tokyo; Research Department (TN), BIKEN, Osaka; and Infectious Disease Surveillance Center (T Fujimoto, NH, KT-T), National Institute of Infectious Diseases, Tokyo, Japan.

    A naturally occurring feline APOBEC3 variant that loses anti-lentiviral activity by lacking two amino acid residues.
    J Gen Virol 2018 Apr 3. Epub 2018 Apr 3.
    1​Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
    Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) is a mammalian protein that restricts lentiviral replication. Various polymorphisms of mammalian APOBEC3 genes have been observed in humans, Old World monkeys and domestic cats; however, the genetic diversity of APOBEC3 genes in other mammals remains unaddressed. Here we identify a novel haplotype of the feline APOBEC3Z3 gene, an APOBEC3 gene that restricts feline immunodeficiency virus (FIV) replication, in a Eurasian lynx (Lynx lynx). Read More

    A Novel Diagnostic Scoring System to Differentiate between Legionella pneumophila Pneumonia and Streptococcus pneumoniae Pneumonia.
    Intern Med 2018 Mar 30. Epub 2018 Mar 30.
    Kyorin University School of Medicine, Department of Respiratory Medicine, Japan.
    Objective We investigated a novel diagnostic scoring system to differentiate Legionella pneumophila pneumonia from Streptococcus pneumoniae pneumonia. Methods We retrospectively reviewed the clinical data of 62 patients with L. pneumophila pneumonia (L-group) and 70 patients with S. Read More

    Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer's Disease Model Neurons.
    Biol Pharm Bull 2018 ;41(4):451-457
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka.
    Alzheimer's disease (AD) is the most common cause of dementia, with progressive memory impairment. Recently, neprilysin, a β-amyloid (Aβ)-degrading enzyme has become featured as a drug target for AD. Previously, we identified nobiletin from citrus peels as a natural compound possessing anti-dementia activity. Read More

    Lung cancer in connective tissue disease-associated interstitial lung disease: clinical features and impact on outcomes.
    J Thorac Dis 2018 Feb;10(2):799-807
    Department of Respiratory Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan.
    Backgrounds: Lung cancer (LC) adversely impacts survival in patients with idiopathic pulmonary fibrosis. However, little is known about LC in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). The aim of this study was to evaluate the prevalence of and risk factors for LC in CTD-ILD, and the clinical characteristics and survival of CTD-ILD patients with LC. Read More

    Angiolymphoid hyperplasia with eosinophilia: a case report.
    J Med Case Rep 2018 Apr 2;12(1):89. Epub 2018 Apr 2.
    Department of Pathology, Tishreen University Hospital, Tishreen University, Lattakia, Syria.
    Background: Angiolymphoid hyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area.

    Case Presentation: In this case, we report a 13-year-old Caucasian girl with bilateral, huge, protruding, and yellowish nostril masses which were peculiar in location and of gross appearance. Read More

    Reframing the approach to patients with hepatocellular carcinoma: Longitudinal assessment with HALTHCC improves ablate and wait strategy.
    Hepatology 2018 Mar 31. Epub 2018 Mar 31.
    Cleveland Clinic Lerner College of Medicine and Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
    Patients with hepatocellular carcinoma (HCC) are screened at presentation for appropriateness of liver transplantation (LT) using morphometric criteria, which poorly specifies risk. Morphology is the crux of measuring tumor response to locoregional therapy (LRT) using modified response evaluation criteria in solid tumors (mRECIST). This study investigated the utility of following a continuous risk score (hazard associated with liver transplantation in HCC [HALTHCC]) to longitudinally assess risk. Read More

    Risk, Timing and Predictors of Disease Flare after Discontinuation of Anti-Tumor Necrosis Factor (TNF) Therapy in Children with Polyarticular Forms of Juvenile Idiopathic Arthritis (JIA) in Clinical Inactive Disease.
    Arthritis Rheumatol 2018 Mar 31. Epub 2018 Mar 31.
    Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
    Objective: Determine the frequency, time-to-flare, and predictors of disease flare upon withdrawal of anti-tumor necrosis factor (TNF) therapy in children with polyarticular forms of juvenile idiopathic arthritis (PF-JIA) who demonstrated ≥ 6 continuous months of clinical inactive disease (CID).

    Methods: In 16 centers 137 patients with PF-JIA in CID on anti-TNF therapy (42% of whom were also on methotrexate [MTX]) were prospectively followed. If CID was maintained for the initial 6 months on study anti-TNF was stopped and patients assessed for flare at 1, 2, 3, 4, 6, and 8 months. Read More

    Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease.
    J Gastroenterol Hepatol 2018 Mar 30. Epub 2018 Mar 30.
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Background And Aim: Patients with inflammatory bowel disease (IBD) are at a high risk of low bone mineral density (BMD). Reportedly, clinical and genetic factors cause low BMD in Caucasians; however, studies in non-Caucasian populations remain scarce.

    Methods: Clinical risk factors for low BMD were investigated in 266 Japanese patients with IBD, and a genome-wide association analysis (GWAS) was performed using linear regression with associated clinical factors as covariates. Read More

    Alcohol consumption and incidence of proteinuria: a retrospective cohort study.
    Clin Exp Nephrol 2018 Mar 29. Epub 2018 Mar 29.
    Steering Committee for the "Research on the Positioning of Chronic Kidney Disease (CKD) in Specific Health Check and Guidance in Japan", Tokyo, Japan.
    Background: Previous studies report conflicting results of a dose-dependent association between alcohol consumption and incidence of chronic kidney disease. Only a few studies have assessed the clinical impact of > 45-65 g/day of critically high alcohol consumption.

    Methods: This retrospective cohort study included 88,647 males and 88,925 females with dipstick urinary protein ≤ ± and estimated glomerular filtration rate ≥ 60 mL/min/1. Read More

    Malignant Disease as a Comorbidity in Patients with Severe Aortic Stenosis: Clinical Presentation, Outcomes, and Management.
    Eur Heart J Qual Care Clin Outcomes 2018 Mar 27. Epub 2018 Mar 27.
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Aim: To investigate the effect of malignancy on the outcomes of patients with severe aortic stenosis (AS) and the management strategy for AS with malignancy.

    Methods: Using data of 3815 patients with severe AS in a retrospective multicenter registry (CURRENT AS registry), we compared 3-year clinical outcomes among three groups based on malignancy status: with malignancy currently under treatment including best supportive care (malignancy group), with a history of malignancy without any current treatment (past history group), or without history of malignancy (no malignancy group).

    Results: Patients in the malignancy group (N = 124) were more often men and had higher prevalence of low body mass index, recurrence of malignancy, anemia, and asymptomatic status, despite comparable surgical risks and echocardiographic parameters. Read More

    A phase II, multicenter, single-arm trial of eribulin as first- or second-line chemotherapy for HER2-negative advanced or metastatic breast cancer: evaluation of efficacy, safety, and patient-reported outcomes.
    Cancer Chemother Pharmacol 2018 Mar 28. Epub 2018 Mar 28.
    Department of Breast and Endocrine Surgery, Osaka Medical College Hospital, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.
    Purpose: Although eribulin is a suitable option for early-line treatment of metastatic breast cancer (MBC), data on first- or second-line use of eribulin for human epidermal growth factor receptor 2 (HER2)-negative MBC are still limited. Therefore, we conducted a phase II trial to investigate the efficacy and safety of eribulin for first- or second-line chemotherapy for HER2-negative MBC.

    Materials And Methods: We performed a phase II, open-label, single-arm, multicenter study in Japan. Read More

    A feasibility study of postoperative adjuvant chemotherapy with fluoropyrimidine S-1 in patients with stage II-IIIA non-small cell lung cancer.
    J Med Invest 2018 ;65(1.2):90-95
    Department of Thoracic, Endocrine Surgery and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School.
    Background: Adjuvant chemotherapy with uracil tegafur (UFT) improved survival among patients with completely resected stage I lung adenocarcinoma. S-1, an oral dihydropyrimidine dehydrogenase (DPD)-inhibitory 5-fluorouracil, is a more potent DPD inhibitor than UFT;therefore, we hypothesized that postoperative adjuvant chemotherapy with S-1 would be effective for advanced non-small cell lung cancer (NSCLC). We conducted a feasibility study of S-1 as postoperative adjuvant chemotherapy in patients with curatively resected pathological stage bold I back 10 bold I and bold I back 10 bold I back 20 bold I A NSCLC. Read More

    Sex Differences in Long-Term Clinical Outcomes in Patients With Atrial Fibrillation Undergoing Coronary Stent Implantation.
    Circ J 2018 Mar 29. Epub 2018 Mar 29.
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
    Background: Patients with concomitant atrial fibrillation (AF) and coronary stenting are at high risk for both cardiovascular and bleeding events. We aimed to evaluate the influence of sex on long-term clinical outcomes in this patient subset.Methods and Results:We identified 1,450 patients with AF and coronary stenting in a patient-level pooled database from 3 Japanese studies, and compared 3-year clinical outcomes between men and women (n=1,075, and n=375, respectively). Read More

    Regulatory CD4 T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B.
    Circulation 2018 Mar 27. Epub 2018 Mar 27.
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA & Department of Bioengineering, University of California, San Diego, La Jolla, CA
    -CD4 T cells play an important role in atherosclerosis, but their antigen specificity is poorly understood. Immunization with apolipoprotein B (ApoB, core protein of low density lipoprotein) is known to be atheroprotective in animal models. Here, we report on a human APOB peptide, p18, that is sequence-identical in mouse ApoB and binds to both mouse and human MHC-II. Read More

    Helicobacter pylori Eradication Therapy Ameliorates Latent Digestive Symptoms in Chronic Atrophic Gastritis.
    Digestion 2018 Mar 27;97(4):333-339. Epub 2018 Mar 27.
    Background/aims: This study investigated the effect of Helicobacter pylori eradication therapy on latent digestive symptoms in chronic atrophic gastritis.

    Methods: We enrolled 650 health checkup patients who underwent eradication therapy for chronic gastritis and completed a self-report questionnaire before and after the treatment between January 2014 and December 2016 at the Japanese Red Cross Society Kyoto Daiichi Hospital.

    Results: H. Read More

    Performance of the St George's Respiratory Questionnaire in patients with connective tissue disease-associated interstitial lung disease.
    Respirology 2018 Mar 25. Epub 2018 Mar 25.
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Background And Objective: The St George's Respiratory Questionnaire (SGRQ) is a self-administered questionnaire used to assess health-related quality of life (HRQoL) in various chronic respiratory diseases. Few studies have assessed the performance of the SGRQ in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). We aimed to examine the SGRQ's performance characteristics and generate data to support its reliability and validity in patients with CTD-ILD. Read More

    Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.
    Cancer Med 2018 Mar 23. Epub 2018 Mar 23.
    Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
    Surgical resection is the only treatment for chondrosarcomas, because of their resistance to chemotherapy and radiotherapy; therefore, additional strategies are crucial to treat chondrosarcomas. Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor, which has been reported as a possible therapeutic target in certain malignancies including chondrosarcomas. In this study, we demonstrated that a nonsteroidal anti-inflammatory drug, zaltoprofen, could induce PPARγ activation and elicit anti-tumor effects in chondrosarcoma cells. Read More

    Generation and validation of novel anti-bovine CD163 monoclonal antibodies ABM-1A9 and ABM-2D6.
    Vet Immunol Immunopathol 2018 Apr 15;198:6-13. Epub 2018 Feb 15.
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido, 069-8501, Japan. Electronic address:
    The scavenger receptor CD163 is widely used as a cell signature for alternatively active "M2" macrophages in mammals. In this study, we generated two monoclonal antibodies, ABM-1A9 and ABM-2D6, against the extracellular region of bovine CD163. Conventional Western blotting using the antibodies yielded immunoreactive bands of bovine CD163 at 130 and 150 kDa in non-reduced and reduced spleen lysates, respectively. Read More

    Acquired von Willebrand Syndrome Complicating Nephrotic Syndrome: A Case of a Patient With Membranous Nephropathy.
    Clin Med Insights Case Rep 2018 13;11:1179547618763371. Epub 2018 Mar 13.
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
    Acquired von Willebrand syndrome (AVWS) is a rare clinical entity presenting with heterogeneous hemorrhagic manifestations, although some subsets of patients with AVWS may be asymptomatic until they are exposed to major trauma, an invasive procedure, or surgery. We herein report one such case in a 73-year-old male patient with nephrotic syndrome with a prolonged active partial thromboplastin time. We initially did not deal with this distinct abnormal clotting profile seriously, but persistent bleeding after a retroperitoneoscopic-assisted renal biopsy that allowed us to ascribe his nephrotic syndrome to membranous nephropathy fortuitously led to the discovery of concurrent AVWS. Read More

    Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease.
    World J Gastroenterol 2018 Mar;24(11):1239-1249
    Department of Internal Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
    Aim: To examine the relationship between serum autotaxin (ATX) concentrations and clinicopathological findings in non-alcoholic fatty liver disease (NAFLD) patients.

    Methods: One hundred eighty-six NAFLD patients who had undergone liver biopsy between 2008 and 2017 were retrospectively enrolled. Serum samples were collected at the time of biopsy and ATX was measured by enzyme immunoassays. Read More

    Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma.
    N Engl J Med 2018 04 21;378(14):1277-1290. Epub 2018 Mar 21.
    From Memorial Sloan Kettering Cancer Center, New York (R.J.M.), and Roswell Park Cancer Institute, Buffalo (S.G.) - both in New York; University of Texas M.D. Anderson Cancer Center, Houston (N.M.T., P. Sharma); Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center (D.F.M.), and Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School (T.K.C.), Boston; Centro Internacional de Estudios Clínicos (O.A.F.) and Fundación Arturo López Pérez (P. Salman), Santiago, Chile; Palacký University and University Hospital Olomouc, Olomouc, Czech Republic (B.M.); Fox Chase Cancer Center, Philadelphia (E.R.P.); Hôpitaux Universitaires de Strasbourg, Strasbourg (P.B.), Bordeaux University Hospital, Hôpital Saint-André, Bordeaux (A.R.), and Institut Gustave Roussy, Villejuif (B.E.) - all in France; Istituto di Ricovero e Cura a Carattere Scientifico San Matteo University Hospital Foundation, Pavia (C.P.), and Ospedale San Donato, Azienda Unità Sanitaria Locale Toscana Sud-Est, Istituto Toscano Tumori, Arezzo (S.B.) - both in Italy; Barts Cancer Institute, Cancer Research UK Experimental Cancer Medicine Centre, Queen Mary University of London, Royal Free NHS Trust (T.P.), and Cancer Research UK (R.H.), London; Aarhus University Hospital, Aarhus, Denmark (F.D.); Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, and Tel Aviv University, Tel Aviv - both in Israel (V.N.); British Columbia Cancer Agency, Vancouver, Canada (C.K.K.); Westmead Hospital and Macquarie University, Sydney (H.G.); Jena University Hospital, Jena, Germany (M.-O.G.); Centro de Pesquisa em Oncologia, Hospital São Lucas, Porto Alegre, Brazil (C.H.B.); Niigata University, Niigata, Japan (Y.T.); Hospital Universitario 12 de Octubre, Madrid (D.C.); Cleveland Clinic Taussig Cancer Institute, Cleveland (B.I.R.); Bristol-Myers Squibb, Princeton, NJ (A.C.C., S.M., M.B.M., M.W.-R., J.D.); and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore (H.J.H.).
    Background: Nivolumab plus ipilimumab produced objective responses in patients with advanced renal-cell carcinoma in a pilot study. This phase 3 trial compared nivolumab plus ipilimumab with sunitinib for previously untreated clear-cell advanced renal-cell carcinoma.

    Methods: We randomly assigned adults in a 1:1 ratio to receive either nivolumab (3 mg per kilogram of body weight) plus ipilimumab (1 mg per kilogram) intravenously every 3 weeks for four doses, followed by nivolumab (3 mg per kilogram) every 2 weeks, or sunitinib (50 mg) orally once daily for 4 weeks (6-week cycle). Read More

    Substantial Decrease in Plasmalogen in the Heart Associated with Tafazzin Deficiency.
    Biochemistry 2018 Apr 30;57(14):2162-2175. Epub 2018 Mar 30.
    Tafazzin is the mitochondrial enzyme that catalyzes transacylation between a phospholipid and a lysophospholipid in remodeling. Mutations in tafazzin cause Barth syndrome, a potentially life-threatening disease with the major symptom being cardiomyopathy. In the tafazzin-deficient heart, cardiolipin (CL) acyl chains become abnormally heterogeneous unlike those in the normal heart with a single dominant linoleoyl species, tetralinoleoyl CL. Read More

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