Search our Database of Scientific Publications and Authors

I’m looking for a

    7715 results match your criteria Kimura Disease

    1 OF 155

    The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.
    Blood Cancer J 2017 Feb 17;7(2):e527. Epub 2017 Feb 17.
    Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Saga University, Saga, Japan.
    Disease recurrence is the major problem in the treatment of acute myeloid leukemia (AML). Relapse is driven by leukemia stem cells, a chemoresistant subpopulation capable of re-establishing disease. Patients with p53 mutant AML are at an extremely high risk of relapse. Read More

    Comparison of clinical and pathological features of lung lesions of systemic IgG4-related disease and idiopathic multicentric Castleman's disease.
    Histopathology 2017 Feb 16. Epub 2017 Feb 16.
    Division of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan, and Tokyo Diffuse Lung Diseases Study Group.
    Aims: The lung lesion (IgG4-L) of IgG4-related disease (IgG4-RD) is a condition that occurs together with IgG4-RD and often mimics the lung lesion (iMCD-L) of idiopathic multicentric Castleman's disease (iMCD). Because no clinical and pathological studies had previously compared features of these diseases, we undertook this comparison with clinical and histological data.

    Methods And Results: Nine patients had IgG4-L (high levels of serum IgG4 and of IgG4(+) cells in lung specimens; typical extrapulmonary manifestations). Read More

    Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors.
    Sci Rep 2017 Feb 13;7:42367. Epub 2017 Feb 13.
    Department of Systems Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan.
    Efficient differentiation of human pluripotent stem cells (hPSCs) into neurons is paramount for disease modeling, drug screening, and cell transplantation therapy in regenerative medicine. In this manuscript, we report the capability of five transcription factors (TFs) toward this aim: NEUROG1, NEUROG2, NEUROG3, NEUROD1, and NEUROD2. In contrast to previous methods that have shortcomings in their speed and efficiency, a cocktail of these TFs as synthetic mRNAs can differentiate hPSCs into neurons in 7 days, judged by calcium imaging and electrophysiology. Read More

    Confounding effects of microbiome on the susceptibility of TNFSF15 to Crohn's disease in the Ryukyu Islands.
    Hum Genet 2017 Feb 14. Epub 2017 Feb 14.
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, 252-0674, Japan.
    Crohn's disease (CD) involves chronic inflammation in the gastrointestinal tract due to dysregulation of the host immune response to the gut microbiome. Even though the host-microbiome interactions are likely contributors to the development of CD, a few studies have detected genetic variants that change bacterial compositions and increase CD risk. We focus on one of the well-replicated susceptible genes, tumor necrosis factor superfamily member 15 (TNFSF15), and apply statistical analyses for personal profiles of genotypes and salivary microbiota collected from CD cases and controls in the Ryukyu Islands, southernmost islands of the Japanese archipelago. Read More

    Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals.
    Clin Exp Nephrol 2017 Feb 14. Epub 2017 Feb 14.
    Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8574, Japan.
    Background: The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels. Read More

    Ca(2+) -permeable AMPA receptors associated with epileptogenesis of hypothalamic hamartoma.
    Epilepsia 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan.
    Hypothalamic hamartoma (HH), composed of neurons and glia without apparent cytologic abnormalities, is a rare developmental malformation in humans. Patients with HH often have characteristic medically refractory gelastic seizures, and intrinsic epileptogenesis within the lesions has been speculated. Herein we provide evidence to suggest that in HH neurons, Ca(2+) permeability through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors is aberrantly elevated. Read More

    A prospective multi-institutional validity study to evaluate the accuracy of clinical diagnosis of pathological stage III gastric cancer (JCOG1302A).
    Gastric Cancer 2017 Feb 13. Epub 2017 Feb 13.
    Division of Upper Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
    Background: Neoadjuvant chemotherapy (NAC) followed by radical surgery is a promising strategy to improve survival of patients with stage III gastric cancer, but is associated with the risk of preoperative overdiagnosis by which patients with early disease may receive unnecessary intensive chemotherapy.

    Methods: We assessed the validity of a preoperative diagnostic criterion in a prospective multicenter study. Patients with gastric cancer with a clinical diagnosis of T2/T3/T4, M0, except for diffuse large tumors and extensive bulky nodal disease, were eligible. Read More

    Patient-specific assessment of hemodynamics by computational fluid dynamics in patients with bicuspid aortopathy.
    J Thorac Cardiovasc Surg 2017 Jan 11. Epub 2017 Jan 11.
    Division of Cardiovascular Surgery, Department of Surgery, Jichi Medical University, Saitama, Japan.
    Objective: Hemodynamics related to eccentric blood flow may factor into the development of bicuspid aortic valve aortopathy. We investigated wall shear stress distribution by means of magnetic resonance imaging-based computational fluid dynamics in patients with a bicuspid aortic valve.

    Methods: Included were 12 patients with a bicuspid aortic valve (aortic stenosis, n = 11; root enlargement, n = 1). Read More

    Determination of methylmalonyl coenzyme A by ultra high-performance liquid chromatography tandem mass spectrometry for measuring propionyl coenzyme A carboxylase activity in patients with propionic acidemia.
    J Chromatogr B Analyt Technol Biomed Life Sci 2017 Feb 6;1046:195-199. Epub 2017 Feb 6.
    Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address:
    Propionic acidemia (PA) is an inherited metabolic disease caused by low activity of propionyl coenzyme A (CoA) carboxylase (PCC), which metabolizes propionyl-CoA into methylmalonyl-CoA. Although many patients with PA have been identified by tandem mass spectrometry since the test was first included in neonatal mass screening in the 1990s, the disease severity varies. Thus, determining the specific level of PCC activity is considered to be helpful to grasp the severity of PA. Read More

    Extraperitoneal Radical Trachelectomy With Pelvic Lymphadenectomy: A Novel Fertility-Preserving Option for Early Stage Cervical Cancer Patients.
    Int J Gynecol Cancer 2017 Mar;27(3):537-542
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
    Objective: Radical trachelectomy combined with pelvic lymphadenectomy has been used to treat early stage cervical cancer patients who wish to preserve their fertility. Although vaginal, abdominal, laparoscopic, and robotic approaches have been used during this procedure, all of these approaches cause peritoneal damage, which could result in periadnexal adhesion. The aim of the present study was to introduce and discuss a novel fertility-preserving option, extraperitoneal radical trachelectomy with pelvic lymphadenectomy. Read More

    Ad hoc vs. Non-ad hoc Percutaneous Coronary Intervention Strategies in Patients With Stable Coronary Artery Disease.
    Circ J 2017 Feb 7. Epub 2017 Feb 7.
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
    Background: Few studies have evaluated the prevalence and clinical outcomes of ad hoc percutaneous coronary intervention (PCI), performing diagnostic coronary angiography and PCI in the same session, in stable coronary artery disease (CAD) patients.Methods and Results:From the CREDO-Kyoto PCI/CABG registry cohort-2, 6,943 patients were analyzed as having stable CAD and undergoing first PCI. Ad hoc PCI and non-ad hoc PCI were performed in 1,722 (24. Read More

    Screening for hereditary angioedema (HAE) at 13 emergency centers in Osaka, Japan: A prospective observational study.
    Medicine (Baltimore) 2017 Feb;96(6):e6109
    aDepartment of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine bEmergency and Critical Care Medical Center, Osaka Police Hospital cSenri Critical Care Medical Center, Osaka Saiseikai Senri Hospital dEmergency and Critical Care Medicine, Kishiwada Tokushukai Hospital eSenshu Trauma and Critical Care Center, Rinku General Medical Center fEmergency Division, Osaka Red Cross Hospital gDepartment of Emergency Medicine, Osaka General Medical Center hOsaka Prefectural Nakakawachi Medical Center of Acute Medicine iTraumatology and Critical Care Medical Center, National Hospital Organization Osaka National Hospital jEmergency and Critical Care Medical Center, Osaka City General Hospital kOsaka Mishima Emergency Critical Care Center lDepartment of Critical Care Medical Center, Kinki University School of Medicine mDepartment of Trauma and Critical Care Medicine, Osaka City University Graduate School of Medicine, Osaka nDepartment of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan.
    Hereditary angioedema (HAE) with deficiency of C1 inhibitor (C1-INH) is an autosomal-dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The objective is to study the incidence of HAE among patients who visit the emergency department.This was a 3-year prospective observational screening study involving 13 urban tertiary emergency centers in Osaka prefecture, Japan. Read More

    Decreased left ventricular stroke volume is associated with low-grade exercise tolerance in patients with chronic obstructive pulmonary disease.
    BMJ Open Respir Res 2017 25;4(1):e000158. Epub 2017 Jan 25.
    Department of Cardiology, Pulmonology, and Nephrology , Yamagata University School of Medicine , Yamagata , Japan.
    Background: Low-grade exercise tolerance is associated with a poor prognosis in patients with chronic obstructive pulmonary disease (COPD). The 6 min walk test (6MWT) is commonly used to evaluate exercise tolerance in patients with COPD. However, little is known regarding the relationship between cardiac function and exercise tolerance in patients with COPD. Read More

    High Efficacy of Pazopanib on an Undifferentiated Spindle-cell Sarcoma Resistant to First-line Therapy Is Identified with a Patient-derived Orthotopic Xenograft (PDOX) Nude Mouse Model.
    J Cell Biochem 2017 Feb 8. Epub 2017 Feb 8.
    AntiCancer, Inc., San Diego, CA.
    Undifferentiated spindle-cell sarcoma (USCS) is a recalcitrant cancer. Our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) nude mouse model with the technique of surgical orthotopic implantation (SOI). In the present study, we evaluated the efficacy of standard first-line chemistry of doxorubicin (DOX), gemcitabine (GEM) combined with docetaxel (DOC), compared to pazopanib (PAZ), a multi-targeting tyrosine-kinase inhibitor, in an USCS PDOX model. Read More

    [Primary Lung Cancer Associated with Dilated Phase of Hypertrophic Cardiomyopathy;Report of a Case].
    Kyobu Geka 2017 Feb;70(2):147-150
    Department of General, Endoscopic, Cardiovascular, Thoracic and Breast Surgery, Tsugaru General Hospital, Goshogawara, Japan.
    A 66-year-old man diagnosed as dilated phase of hypertrophic cardiomyopathy (D-HCM) was pointed out an abnormal shadow on routine chest radiography. The patient had past medical history of hypertension, congestive heart failure and chronic obstructive pulmonary disease. The computed tomography showed a 3. Read More

    Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review.
    Am J Dermatopathol 2017 Feb 2. Epub 2017 Feb 2.
    *Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan;†Sapporo Dermatopathology Institute, Sapporo, Japan;‡Department of Plastic and Reconstructive Surgery, Saitama Medical University, Saitama, Japan;§Departments of Dermatology, and¶Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan; and‖Department of Breast Surgery, Kainan Hospital, Yatomi, Japan.
    There is scarcity of information on primary cutaneous low-grade neoplasms commonly known as carcinoid tumors, owing to their rarity. The authors present 3 cases that were named "low-grade neuroendocrine carcinoma of the skin" (LGNECS). These occurred in the dermis and subcutis of the anterior chest or the inguinal region in the elderly. Read More

    Granularity and Laxative Effect of Ultrafine Powder of Dendrobium officinale.
    J Med Food 2017 Feb;20(2):180-188
    1 School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China .
    Constipation is a common disorder that is a significant source of morbidity among people around the world ranging from 2% to 28%. Dendrobium officinale Kimura et Migo is a traditional herbal medicine and health food used for tonicity of the stomach and promotion of body fluid production in China. This study aimed to prepare the ultrafine powder of Dendrobium officinale (UDO) and investigate its laxative effect and potential mechanism in mice with diphenoxylate-induced constipation. Read More

    Aprepitant for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving moderately emetogenic chemotherapy.
    Int J Clin Oncol 2017 Jan 31. Epub 2017 Jan 31.
    Department of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan.
    Background: Our aim was to evaluate the efficacy of oral aprepitant in rescue treatment after the primary rescue for breakthrough chemotherapy-induced nausea and vomiting (CINV) in chemotherapy-naive patients receiving moderately emetogenic chemotherapy (MEC).

    Methods: This was a single-institutional phase 2 study. Patients who had received MEC regimens and developed breakthrough CINV despite antiemetic prophylaxis without aprepitant were treated with primary rescue antiemetic treatments chosen by physicians. Read More

    Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [(11)C]PBB3-PET study.
    Alzheimers Dement (Amst) 2017 22;6:11-20. Epub 2016 Dec 22.
    Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba-shi, Chiba, Japan.
    Introduction: Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear.

    Methods: Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [(11)C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [(11)C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs). Read More

    The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein.
    Nat Commun 2017 Jan 30;8:14259. Epub 2017 Jan 30.
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.
    Diverse cellular proteins and RNAs are tightly regulated in their subcellular localization to exert their local function. Here we report that the tumour suppressor adenomatous polyposis coli protein (APC) directs the localization and assembly of human immunodeficiency virus (HIV)-1 Gag polyprotein at distinct membrane components to enable the efficient production and spread of infectious viral particles. A proteomic analysis and subsequent biomolecular interaction assay reveals that the carboxyl terminus of APC interacts with the matrix region of Gag. Read More

    [A Case of Metastatic Lung Cancer from Colon Cancer with a Long Partial Response with Regorafenib Treatment].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2338-2340
    Dept. of Surgical Oncology, Osaka City University Graduate School of Medicine.
    A 66-year-old woman underwent sigmoidectomy for colon cancer. The final diagnosis was early cancer of pT2 pN0 and M0 (fStage I ). A chest CT revealed lung metastasis and lymph node metastasis 6 years after surgery. Read More

    [Damage Control Surgery for Perforation of Colon Cancer].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1830-1832
    Dept. of Acute Care Surgery, Sakai City Medical Center.
    Perforation due to colon cancer maycause peritonitis and septic shock. In these cases, we maynot be able to rescue the patients in spite of emergencysurgical intervention; in these conditions, owing to limitations of operation time, it is difficult for us to assess the state or extent of the disease and to perform an ideal oncological surgerywith dissection of lymph nodes. To overcome these limitations, we introduce the concept of "damage control surgery" developed in the trauma region to treat perforations of colon cancer. Read More

    Thalamic involvement determined using VSRAD advance on MRI and easy Z-score analysis of (99m)Tc-ECD-SPECT in Gerstmann-Sträussler-Scheinker syndrome with P102L mutation.
    J Neurol Sci 2017 Feb 15;373:27-30. Epub 2016 Dec 15.
    Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Japan.
    Gerstmann-Sträussler-Scheinker syndrome caused by the P102L mutation in the prion protein gene (GSS102) is usually characterized by the onset of slowly progressive cerebellar ataxia, with dementia occurring much later. Because of the relatively long disease course and the prominence of progressive cerebellar ataxia in the early stage, GSS102 is often misdiagnosed as other neurodegenerative disorders. We present two cases of genetically proven GSS102L, both of which present with atrophy and decreased blood flow of the thalamus as determined by voxel-based specific regional analysis system for Alzheimer's disease (VSRAD) advance software and easy Z-score analysis for (99m)Tc-ethyl cysteinate dimer-SPECT, respectively. Read More

    Urinary albumin-to-creatinine ratio is associated with white matter lesions severity in first-ever stroke patients.
    J Neurol Sci 2017 Feb 4;373:258-262. Epub 2017 Jan 4.
    Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Japan.
    Background: The presence of white matter lesions (WML) is an indicator of small vessel disease; however, the underlying pathological mechanisms are still unclear. We aimed to investigate the association of estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) with WML severity in first-ever stroke patients.

    Methods: We retrospectively enrolled 284 consecutive patients (177 male; median age 72years) admitted to our stroke center between May 2010 and January 2012. Read More

    Longitudinal impairment of lung function in school-age children with extremely low birth weights.
    Pediatr Pulmonol 2017 Jan 26. Epub 2017 Jan 26.
    Department of Neonatal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan.
    Objectives: To assess lung function and long-term respiratory outcomes in extremely low birth weight (ELBW) survivors.

    Working Hypothesis: ELBW, especially with respiratory complications in the neonatal period, affects lung function at a later age.

    Study Design: Longitudinal retrospective study. Read More

    Estimated Prevalence of Heterozygous Familial Hypercholesterolemia in Patients With Acute Coronary Syndrome.
    Int Heart J 2017 Feb 24;58(1):88-94. Epub 2017 Jan 24.
    Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine.
    Heterozygous familial hypercholesterolemia (FH) represents a strong risk for development of premature coronary artery disease (CAD). However, the majority of patients with FH are undiagnosed and the prevalence likely represents an underestimate in most countries. In Japan, the possible contribution of FH to the development of CAD may be higher because of the low incidence of CAD among the general population. Read More

    Progression of mean pulmonary arterial pressure in idiopathic pulmonary fibrosis with mild to moderate restriction.
    Respirology 2017 Jan 24. Epub 2017 Jan 24.
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Background And Objective: Elevation of mean pulmonary arterial pressure (MPAP) is associated with poor prognosis in patients with idiopathic pulmonary fibrosis (IPF), yet the progression of MPAP in patients with IPF has not been sufficiently elucidated. We evaluated serial changes in MPAP and its determinants in patients with IPF with mild to moderate restriction.

    Methods: We retrospectively reviewed patients with IPF who underwent initial evaluations including right heart catheterization (RHC) in our institute from May 2007 to December 2013 with follow-up RHC at least 1 year later. Read More

    Effects of caffeine on fractional flow reserve values measured using intravenous adenosine triphosphate.
    Cardiovasc Interv Ther 2017 Jan 21. Epub 2017 Jan 21.
    Department of Cardiology, Tokyo Medical University, Tokyo, Japan.
    We investigated the effects of caffeine intake on fractional flow reserve (FFR) values measured using intravenous adenosine triphosphate (ATP) before cardiac catheterization. Caffeine is a competitive antagonist for adenosine receptors; however, it is unclear whether this antagonism affects FFR values. Patients were evenly randomized into 2 groups preceding the FFR study. Read More

    Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease.
    J Clin Pathol 2017 Jan 20. Epub 2017 Jan 20.
    Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province, Urumqi, China.
    Objective: To investigate the expressions of interleukin (IL)-21 and phosphorylated extracellular signal regulated kinase 1/2 (pERK1/2) in Kimura disease (KD) and to correlate the findings with clinical and prognostic variables.

    Methods: Immunohistochemical analysis of IL-21 and pERK1/2 was performed in 18 cases of KD and five gender- and age-matched control samples. Clinical data were extracted and patients followed up for a mean period of 32. Read More

    A Solid Pseudopapillary Neoplasm of the Pancreas Associated With IgG4-Related Pancreatitis.
    Int J Surg Pathol 2016 Nov 1:1066896916677289. Epub 2016 Nov 1.
    1 Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.
    A solid and cystic pancreatic lesion was incidentally found in a 62-year-old woman on abdominal computed tomography. The lesion was diagnosed as a solid pseudopapillary neoplasm by using endoscopic ultrasound-guided fine needle aspiration, and the tumor was resected. Histologically, the tumor cells had relatively small, round nuclei and papillary-like architecture in a hemorrhagic background. Read More

    Superficial Parotidectomy Plane for Debulking Surgery in Kimura Disease.
    J Craniofac Surg 2017 Jan 18. Epub 2017 Jan 18.
    Oral and Maxillofacial Surgery, Armed Forces Medical College, Pune, India.
    Kimura disease (KD) is a rare chronic inflammatory disorder of unknown etiology representing as solitary or multiple subcutaneous nodules predominantly in the head and neck region. Common sites of involvement are preauricular region, forehead and scalp. The soft tissue localization is often associated with regional lymphadenopathy and enlargement of the major salivary gland. Read More

    Change in number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer.
    Oncol Lett 2016 Dec 11;12(6):4720-4726. Epub 2016 Oct 11.
    Digestive Disease Center, Showa University Koto Toyosu Hospital, Tokyo 135-8577, Japan.
    Detection of circulating tumor cells (CTCs) in peripheral blood is useful for estimating the prognosis of patients with cancer. We previously reported the detection of CTCs by OBP-401, a telomerase-specific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein (GFP) gene. We demonstrated that the number of large (L)-GFP+ cells (≥7. Read More

    Primary Percutaneous Coronary Intervention Followed by Valve Surgery for Acute Coronary Syndrome at Left Main Trunk Complicated With Severe Aortic Stenosis.
    Int Heart J 2017 Feb 17;58(1):125-130. Epub 2017 Jan 17.
    Department of Cardiology, Kyoto First Red Cross Hospital.
    An 89-year-old woman appeared to have acute coronary syndrome at the left main trunk (LMT) complicated with severe aortic stenosis, moderate-severe mitral regurgitation, depressed left ventricular (LV) function, and multivessel disease. Because of sustained hypotension even under intra-aortic balloon pumping support during emergency coronary angiograhy, we performed primary percutaneous coronary intervention solely for the LMT lesion using a bare metal stent, leading to recovery from the shock state. On the second hospital day, based on our heart-team consensus, we performed aortic valve replacement and coronary artery bypass grafting surgery, and added edge-to-edge repair (Alfieri stitch) of the mitral valve, resulting in complete revascularization and dramatically improved LV function. Read More

    Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder.
    J Neuroimmunol 2017 Jan 12. Epub 2017 Jan 12.
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address:
    We examined progranulin (PGRN) levels in cerebrospinal fluid (CSF) samples during the acute phase in 15 patients with neuromyelitis optica spectrum disorders (NMOSD) and compared the results with those from 17 patients with multiple sclerosis (MS), 30 patients with other inflammatory neurological diseases (OIND), and 20 non-inflammatory controls (NIC). CSF PGRN levels of NMOSD patients were significantly higher than those of MS patients and NICs. These levels correlated with CSF interleukin-6 levels, CSF cell counts, CSF protein levels, improvements in the Expanded Disability Status Scale score, and affected total spinal cord lesion length in the NMOSD patients. Read More

    Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.
    JCI Insight 2017 Jan 12;2(1):e89462. Epub 2017 Jan 12.
    Research Center for Biosignaling, Department of; Medical Biology.
    Hypertrophic cardiomyopathy (HCM) is a common heart disease with a prevalence of 1 in 500 in the general population. Several mutations in genes encoding cardiac proteins have been found in HCM patients, but these changes do not predict occurrence or prognosis and the molecular mechanisms underlying HCM remain largely elusive. Here we show that cardiac expression of vacuolar protein sorting 34 (Vps34) is reduced in a subset of HCM patients. Read More

    Novel Treatment of Hepatitis C Virus Infection for Patients with Renal Impairment.
    J Clin Transl Hepatol 2016 Dec 26;4(4):320-327. Epub 2016 Dec 26.
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
    Prevalence of hepatitis C virus (HCV) infection is high in patients with end-stage renal dysfunction, including patients undergoing hemodialysis (HD). The HCV infection itself can cause glomerulonephritis and puts individuals at increased risk of developing end-stage renal disease; fortunately, successful HCV eradication sometimes restore HCV-related renal dysfunction. Moreover, the prognosis of dialysis patients infected with HCV is significantly worse and the renal allograft survival in HCV-infected patients is also worse than in dialysis patients without HCV infection. Read More

    Prognostic roles of tetrahydroxy bile acids in infantile intrahepatic cholestasis.
    J Lipid Res 2017 Jan 10. Epub 2017 Jan 10.
    National Taiwan University Hospital, Taiwan;
    Tetrahydroxy bile acids (THBAs) are hydrophilic and are present at minimal or undetectable levels in healthy human adults but are present at high levels in bile salt export pump (abcb11)-knockout mice. The roles of THBAs in human cholestatic diseases are unclear. We aimed to investigate the presence of THBAs in patients with infantile intrahepatic cholestasis and its correlation with outcome. Read More

    Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse.
    J Toxicol Sci 2017 ;42(1):25-30
    Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo.
    The aryl hydrocarbon receptor (AhR) avidly binds dioxin, a ubiquitous environmental contaminant. Disruption of downstream AhR signaling has been reported to alter neuronal development, and rodent offspring exposed to dioxin during gestation and lactation showed abnormalities in learning and memory, emotion, and social behavior. However, the mechanism behind the disrupted AhR signaling and developmental neurotoxicity induced by xenobiotic ligands remains elusive. Read More

    Newly recognized cerebral infarctions on postmortem imaging: a report of three cases with systemic infectious disease.
    BMC Med Imaging 2017 Jan 10;17(1). Epub 2017 Jan 10.
    Division of Molecular Pathology, Department of Pathological Sciences, School of Medical Sciences, University of Fukui, Fukui, Japan.
    Background: Postmortem imaging (PMI) refers to the imaging of cadavers by computed tomography (CT) and/or magnetic resonance imaging (MRI). Three cases of cerebral infarctions that were not found during life but were newly recognized on PMI and were associated with severe systemic infections are presented.

    Case Presentations: An 81-year-old woman with a pacemaker and slightly impaired liver function presented with fever. Read More

    Blood pressure control status and relationship between salt intake and lifestyle including diet in hypertensive outpatients treated at a general hospital.
    Clin Exp Hypertens 2017 5;39(1):29-33. Epub 2017 Jan 5.
    c Department of Medical Technology , Teikyo University Fukuoka , Omuta , Fukuoka , Japan.
    The purpose of the present study was to investigate blood pressure (BP) control and salt intake in hypertensive outpatients treated at a general hospital and to examine the relationship between their lifestyles and amount of salt intake. Subjects comprised 429 hypertensive patients (206 males, 223 females, and average age of 71 ± 11 years). We estimated 24-hour salt excretion using spot urine samples and assessed lifestyle using a self-description questionnaire. Read More

    A Case of Sialolithiasis in a Minor Salivary Gland of the Buccal Mucosa.
    J Clin Diagn Res 2016 Nov 1;10(11):ZD06-ZD07. Epub 2016 Nov 1.
    Director, Department of Oral and Maxillofacial Surgery, Ogaki Municipal Hospital , Ogaki, Gifu, Japan .
    Sialolithiasis is a common disease of the major salivary glands. In contrast, Sialolithiasis of Minor Salivary Glands (SMSG) is very rare. Only 2% of all cases of sialolithiasis develop in minor salivary glands and sublingual glands. Read More

    Chronic total occlusion in a non-infarct-related artery is closely associated with increased five-year mortality in patients with ST-segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention (from the CREDO-Kyoto AMI registry).
    EuroIntervention 2017 Feb;12(15):e1874-e1882
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Aims: We sought to investigate the clinical impact of chronic total occlusion (CTO) in a non-infarct-related artery (IRA) on long-term cardiovascular outcomes in patients with ST-elevation myocardial infarction (STEMI).

    Methods And Results: Among 5,429 patients enrolled in the CREDO-Kyoto AMI registry, the current study population consisted of 2,045 STEMI patients with multivessel disease (MVD) who underwent primary PCI within 24 hours after symptom onset. The cumulative five-year, 30-day and 30-day to five-year incidences of all-cause death were all significantly higher in the CTO group than in the non-CTO group (37. Read More

    Surgery for malignant pulmonary nodules in patients with a history of oesophageal cancer.
    Interact Cardiovasc Thorac Surg 2016 Dec 31. Epub 2016 Dec 31.
    Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
    Objectives: The objective of this study is to analyse the short- and long-term results of surgery for malignant pulmonary nodules in patients with a history of oesophageal cancer (EC) in order to assess the significance of surgery in these patients.

    Methods: The data of 28 consecutive patients with a history of EC who underwent pulmonary resection for malignant pulmonary nodules were reviewed. The perioperative and long-term results were analysed. Read More

    Kimura's disease in a 50-year-old Tunisian man.
    Eur Ann Otorhinolaryngol Head Neck Dis 2016 Dec 28. Epub 2016 Dec 28.
    Service d'anatomopathologie, hôpital d'instruction des armées Bégin, 94160 Saint-Mandé, France.
    Introduction: Kimura's disease is an uncommon disease of unknown aetiology affecting men in their thirties from Southeast Asia. The authors report a case of Kimura's disease in a 50-year-old Tunisian man that was diagnosed after surgery.

    Case Report: This patient had two 2-cm diameter chronic nodular lesions over the right mandible with no local inflammation and no other clinical findings of systemic disease. Read More

    Clinical impact of complete revascularization in elderly patients with multi-vessel coronary artery disease undergoing percutaneous coronary intervention: A sub-analysis of the SHINANO registry.
    Int J Cardiol 2017 Mar 21;230:413-419. Epub 2016 Dec 21.
    Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan; Department of Cardiology, Nagano Municipal Hospital, Nagano, Japan.
    Background: Prior reports have revealed that complete revascularization (CR) by percutaneous coronary intervention (PCI) decreased ischemic events. However, little is known about the efficacy of CR using PCI in elderly patients with multi-vessel coronary artery disease (CAD). We evaluated the 1-year effectiveness of CR-PCI in elderly patients (≥75years old) with multi-vessel CAD. Read More

    Potentially inappropriate medications in elderly Japanese patients: effects of pharmacists' assessment and intervention based on Screening Tool of Older Persons' Potentially Inappropriate Prescriptions criteria ver.2.
    J Clin Pharm Ther 2016 Dec 31. Epub 2016 Dec 31.
    Department of Pharmacy, Kobe University Hospital, Kobe, Japan.
    What Is Known And Objectives: The Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (stopp) criteria were updated in 2014 (stopp criteria ver.2), but few studies have evaluated the usefulness of stopp criteria in elderly patients. This prospective observational study evaluated the prevalence of potentially inappropriate medications (PIMs), and the efficacy of hospital pharmacists' assessment and intervention based on stopp criteria ver. Read More

    Three unusual histopathological presentations of angiolymphoid hyperplasia with eosinophilia.
    J Cutan Pathol 2017 Mar 2;44(3):300-306. Epub 2017 Feb 2.
    Department of Pathology, Southern California Kaiser Permanente, Los Angeles Medical Center (LAMC), Kaiser Permanente, Los Angeles, California.
    Angiolymphoid hyperplasia with eosinophilia (ALHE) is a poorly understood benign vasculoproliferative disorder. Histopathologically, the lesions are composed of a dermal or subcutaneous proliferation of blood vessels of varying sizes with plump and bland endothelial cells, which often show vacuolization and protrusion of the cytoplasm into the lumen. The vascular proliferation is admixed with a diffuse inflammatory infiltrate composed of lymphocytes, eosinophils and mast cells. Read More

    1 OF 155