9,521 results match your criteria Kimura Disease


Impact of tacrolimus versus cyclosporin A on renal function during the first year after heart transplant.

ESC Heart Fail 2020 May 23. Epub 2020 May 23.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Aims: Nephrotoxicity of calcineurin inhibitors (CNIs) is associated with adverse events in patients undergoing heart transplant (HTx), although studies directly comparing tacrolimus (TAC) versus cyclosporin A (CsA), especially in combination with everolimus and low-dose CNIs approach, are limited. Thus, we sought to investigate the associations of TAC and CsA with clinical outcomes in HTx recipients, with specific focus on renal function.

Methods And Results: From August 2007 to February 2017, 72 consecutive patients (39 treated with TAC vs. Read More

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http://dx.doi.org/10.1002/ehf2.12749DOI Listing

Pulmonary valve replacement after tetralogy of Fallot repair in a patient with immune thrombocytopenia.

J Card Surg 2020 May 22. Epub 2020 May 22.

Department of Cardiovascular Surgery, Keio University School of Medicine, Tokyo, Japan.

Marked thrombocytopenia causes significant bleeding in cardiovascular surgery. Herein, we describe the case of a 47-year-old woman with immune thrombocytopenia who underwent successful pulmonary valve replacement for pulmonary valve regurgitation and stenosis after complete repair of tetralogy of Fallot. Her platelet count decreased significantly to less than 5 × 10 /L on postoperative day 3, thus multiple platelet transfusions were given. Read More

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http://dx.doi.org/10.1111/jocs.14640DOI Listing

Thymus and activation-regulated chemokine (TARC/CCL17) predicts decline of pulmonary function in patients with chronic obstructive pulmonary disease.

Allergol Int 2020 May 19. Epub 2020 May 19.

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine, Yamagata, Japan.

Background: The deterioration of pulmonary function, such as FEV-decline, is strongly associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, few investigations shed light on useful biomarkers for predicting the decline of pulmonary function. We evaluated whether thymus and activation-regulated chemokine (TARC), a Th2 inflammation marker, could predict rapid FEV-decline in COPD patients. Read More

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http://dx.doi.org/10.1016/j.alit.2020.04.004DOI Listing

New MRI Findings in Fukuyama Congenital Muscular Dystrophy: Brain Stem and Venous System Anomalies.

AJNR Am J Neuroradiol 2020 May 21. Epub 2020 May 21.

From the Departments of Child Neurology (A.H.-I., A.I., E.T., H.K., M.S.).

Background And Purpose: Leptomeningeal glioneuronal heterotopia of the brain stem and cerebral migration abnormality were pathologically reported in Fukuyama congenital muscular dystrophy, but the radiologic assessments of the brain stem and cerebral venous system (which may be involved in the development of the anomaly) were insufficient. Here, we evaluated the brain stem and cerebral veins on MR imaging in patients with Fukuyama congenital muscular dystrophy.

Materials And Methods: We retrospectively reviewed the MR imaging findings of 27 patients with Fukuyama congenital muscular dystrophy. Read More

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http://dx.doi.org/10.3174/ajnr.A6577DOI Listing

Changed Amino Acids in NAFLD and Liver Fibrosis: A Large Cross-Sectional Study without Influence of Insulin Resistance.

Nutrients 2020 May 17;12(5). Epub 2020 May 17.

Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.

Altered amino acid levels have been found in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). However, it is not clear whether this alteration is due to altered hepatic metabolism or insulin resistance. The aim of this study was to clarify the association among amino acid levels, fatty liver, and liver fibrosis while eliminating the influence of insulin resistance. Read More

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http://dx.doi.org/10.3390/nu12051450DOI Listing

Sporadic neurofibroma of transverse colon in a patient without neurofibromatosis type 1: A case report.

Int J Surg Case Rep 2020 May 8;71:19-22. Epub 2020 May 8.

Department of Pathology, Nagoya City East Medical Center, Nagoya, Japan.

Introduction: The occurrence of sporadic colonic neurofibroma particularly in a patient without neurofibromatosis type 1 has been rarely reported. Therefore, the clinical significance of this disease has not been fully elucidated.

Presentation Of Case: An 81-year-old woman with a positive fecal occult blood test result was referred to our institution for the evaluation of anemia. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235934PMC

Salvation of peritoneal dialysis catheter potency by using an angiographic guidewire.

Perit Dial Int 2020 May 19:896860820927136. Epub 2020 May 19.

Division of Nephrology, Department of Internal Medicine, International University of Health and Welfare School of Medicine, Shizuoka, Japan.

Catheter obstruction is a major cause of dialysate flow problems in peritoneal dialysis (PD). It will lead to PD technique failure, when its conservative management such as vigorous instillation of dialysate occasionally fails to salvage the catheter potency. In this report, we present two cases of catheter obstruction caused by intraluminal clots of PD catheter. Read More

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http://dx.doi.org/10.1177/0896860820927136DOI Listing

Type 2 Inflammation Modulates ACE2 and TMPRSS2 in Airway Epithelial Cells.

J Allergy Clin Immunol 2020 May 15. Epub 2020 May 15.

Department of Medicine, College of Medicine Tucson, University of Arizona Health Sciences, Tucson, AZ, USA. Electronic address:

Background: SARS-CoV-2 has dramatically changed our world, country, communities and families. There is controversy regarding risk factors for severe COVID-19 disease. It has been suggested that asthma and allergy are not highly represented as co-morbid conditions associated with COVID-19. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227558PMC

Dataset for the Reporting of Pheochromocytoma and Paraganglioma: Explanations and Recommendations of the Guidelines from the International Collaboration on Cancer Reporting (ICCR).

Hum Pathol 2020 May 11. Epub 2020 May 11.

Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston,USA. Electronic address:

Background And Objectives: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organized to develop evidence-based, internationally agreed upon standardized datasets for each anatomic site, to be used throughout the world. Providing global standardization of pathology tumor classification, staging, and other reporting elements will lead to improved patient management and enhanced epidemiological research.

Methods: Pheochromocytoma and paraganglioma are uncommon and are frequently overlooked in registry datasets. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.04.012DOI Listing

Differences in splicing defects between the grey and white matter in myotonic dystrophy type 1 patients.

PLoS One 2020 14;15(5):e0224912. Epub 2020 May 14.

Department of Internal Medicine Division of Neurology, Hyogo College of Medicine, Nishinomiya, Japan.

Myotonic dystrophy type 1 (DM1) is a multi-system disorder caused by CTG repeats in the myotonic dystrophy protein kinase (DMPK) gene. This leads to the sequestration of splicing factors such as muscleblind-like 1/2 (MBNL1/2) and aberrant splicing in the central nervous system. We investigated the splicing patterns of MBNL1/2 and genes controlled by MBNL2 in several regions of the brain and between the grey matter (GM) and white matter (WM) in DM1 patients using RT-PCR. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224912PLOS

Successful treatment of adalimumab for older Behçet's disease complicated with pulmonary artery thrombosis: A case report.

Int J Rheum Dis 2020 May 13. Epub 2020 May 13.

Department of Immuno-Rheumatology Center, Arisawa General Hospital, Hirakata, Japan.

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http://dx.doi.org/10.1111/1756-185X.13851DOI Listing

Diagnosis Patterns of CKD and Anemia in the Japanese Population.

Kidney Int Rep 2020 May 10;5(5):694-705. Epub 2020 Apr 10.

Medical Affairs, Astellas Pharma Inc., Tokyo, Japan.

Introduction: Although early intervention for chronic kidney disease (CKD) and renal anemia are desirable, these conditions are often asymptomatic during their early stages and may be underdiagnosed.

Methods: We retrospectively analyzed Japanese administrative claims data for general and hospital populations. The data period for the general and hospital data ranged from January 2011 to December 2016 and from April 2008 to July 2017, respectively. Read More

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http://dx.doi.org/10.1016/j.ekir.2020.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210702PMC

Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats.

J Diabetes Res 2020 13;2020:7614035. Epub 2020 Jan 13.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.

Background: Type 2 diabetes (T2D) is a known risk factor for diabetic kidney disease (DKD) and sarcopenia in older patients. Because there may be an interaction between DKD and sarcopenia, the aim of the present study is to investigate the relationship between urinary levels of liver-type fatty acid-binding protein (L-FABP) and sarcopenia using a novel rat model of T2D.

Methods: Male spontaneously diabetic Torii (SDT) fatty rats ( = 5) at 16 weeks of age were used as an animal model of T2D. Read More

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http://dx.doi.org/10.1155/2020/7614035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201485PMC
January 2020

Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship.

J Infect Chemother 2020 May 13. Epub 2020 May 13.

Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine.

We investigated the clinical course of individuals with 2019 novel coronavirus disease (COVID-19) who were transferred from the Diamond Princess cruise ship to 12 local hospitals. The conditions and clinical courses of patients with pneumonia were compared with those of patients without pneumonia. Among 70 patients (median age: 67 years) analyzed, the major symptoms were fever (64. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218347PMC

Oncological outcomes of a multi-center cohort treated with axitinib for metastatic renal cell carcinoma.

Cancer Sci 2020 May 13. Epub 2020 May 13.

Department of Urology, Hokkaido University Hospital, Sapporo, Japan.

The present study aimed to evaluate the efficacy of the real-world use of axitinib and to develop a prognostic model for stratifying patients who could derive long-term benefit from axitinib. This was a retrospective, descriptive study evaluating the efficacy of axitinib in patients with metastatic renal cell carcinoma that had been treated with one or two systemic anti-angiogenic therapy regimens at one of 36 hospitals belonging to the Japan Urologic Oncology Group between January 2012 and February 2019. The primary outcome was overall survival (OS). Read More

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http://dx.doi.org/10.1111/cas.14449DOI Listing

Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan.

J Hum Genet 2020 May 13. Epub 2020 May 13.

Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Variants of leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of familial Parkinson's disease (PD). We aimed to investigate the genetic and clinical features of patients with PD and LRRK2 variants in Japan by screening for LRRK2 variants in three exons (31, 41, and 48), which include the following pathogenic mutations: p.R1441C, p. Read More

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http://dx.doi.org/10.1038/s10038-020-0772-4DOI Listing

Molecular evolution of the capsid () region in human norovirus genogroup II genotype 3.

Heliyon 2020 May 3;6(5):e03835. Epub 2020 May 3.

Department of Health Science, Gunma Paz University Graduate School of Health Sciences, 1-7-1 Tonyamachi, Takasaki-shi, Gunma 370-0006, Japan.

Norovirus GII.3 has been suggested to be a prevalent genotype in patients with acute gastroenteritis. However, the genetic properties of the region encoding the major GII. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205756PMC

Eosinophilic Dermatoses: Recognition and Management.

Am J Clin Dermatol 2020 May 11. Epub 2020 May 11.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Eosinophilic dermatoses encompass a broad spectrum of diseases of different etiologies hallmarked by eosinophilic infiltration of the skin and/or mucous membranes, with or without associated blood eosinophilia. The wide range of dermatological manifestations of this spectrum, including nodules and plaques, pustules, blisters, ulcers, and urticarial lesions, is reflected in a non-univocal classification system. We identified six groups of eosinophilic dermatoses based on the predominant anatomic level of involvement: (1) epidermal; (2) of the dermal-epidermal junction; (3) dermal; (4) of the hypodermis and muscle fascia; (5) of the pilosebaceous unit; and (6) vascular/perivascular. Read More

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http://dx.doi.org/10.1007/s40257-020-00520-4DOI Listing

Contrasting Results from Two Commercial Kits Testing for the Presence of Clostridium perfringens Enterotoxin in Feces from Norovirus-Infected Human Patients.

Clin Lab 2020 May;66(5)

Background: Detection of Clostridium perfringens enterotoxin (CPE) is critical for disease surveillance; however, commercial testing kits produce contrasting results.

Methods: We examined the cause of the differing results from a reversed passive latex agglutination (RPLA) assay (PET-RPLA Toxin Detection Kit) and an enzyme-linked immunosorbent assay (C. perfringens Enterotoxin ELISA Kit) using 73 human norovirus-positive fecal samples from gastroenteritis patients across 22 episodes in Japan. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190801DOI Listing

Serum Levels of Alpha Fetoprotein Increased More Than 10 Years Before Detection of Hepatocellular Carcinoma.

Clin Gastroenterol Hepatol 2020 May 7. Epub 2020 May 7.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK. Electronic address:

Background & Aims: Ultrasound (US)-based screening has been recommended for patients with an increased risk of hepatocellular Carcinoma (HCC). US analysis is, however, limited in patients who are obese or have small tumors. Addition of measurement of serum level of alpha-fetoprotein (AFP) to US analysis can increase detection of HCC. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.04.084DOI Listing

The expression of urokinase-type plasminogen activator system in upper tract urothelial carcinoma and its prognostic value after radical nephroureterectomy.

Urol Oncol 2020 May 4. Epub 2020 May 4.

Department of Urology, Medical University of Vienna, Vienna, Austria; Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX; Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia; Department of Urology, Weill Cornell Medical College, New York, NY, USA; European Association of Urology Research Foundation, Arnhem, Netherlands. Electronic address:

Background: To evaluate the expression pattern and prognostic role of the urokinase-type plasminogen activator (uPA) system in patients who underwent radical nephroureterectomy (RNU) for nonmetastatic upper tract urothelial carcinoma (UTUC).

Methods: A total of 732 patients who were treated with RNU for clinically nonmetastatic UTUC comprised our analytical cohort. Immunohistochemical staining of uPA, uPA receptor (uPAR) and uPA inhibitor (PAI-1) was performed using Murine IgG1 monoclonal antibodies. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.03.030DOI Listing
May 2020
2.768 Impact Factor

Discriminant analysis and interpretation of nuclear chromatin distribution and coarseness using gray-level co-occurrence matrix features for lobular endocervical glandular hyperplasia.

Diagn Cytopathol 2020 May 6. Epub 2020 May 6.

Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan.

Background: Lobular endocervical glandular hyperplasia (LEGH) is a disease considered to be the origin of tumorigenesis of minimal deviation adenocarcinoma, which has characteristic expression in the gastric pyloric mucosa. It is difficult to diagnose by nuclear findings because of lower nuclear atypia. In this study, nuclei of endocervical (EC) and LEGH cells were digitized, and nuclear information was quantified from nuclear images and objectively evaluated using a computer. Read More

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http://dx.doi.org/10.1002/dc.24466DOI Listing

Adequacy evaluation of the annual colonoscopic surveillance and individual difference of disease phenotypes in Lynch syndrome.

Jpn J Clin Oncol 2020 May 6. Epub 2020 May 6.

Department of Surgery, National Hospital Organization Iwakuni Clinical Center, Iwakuni, Japan.

Background: Regular endoscopic surveillance for Lynch syndrome is reported to reduce colorectal cancer (CRC)-related mortality. However, the appropriate surveillance intervals are still unclear. We evaluated the adequacy of annual colonoscopy and investigated the differences in tumor occurrence rates between individual patients. Read More

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http://dx.doi.org/10.1093/jjco/hyaa006DOI Listing

Treatment of Angiolymphoid Hyperplasia With Eosinophilia With Pulsed Dye Laser.

Dermatol Surg 2020 Apr 28. Epub 2020 Apr 28.

Department of Internal Medicine, Division of Dermatology, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1097/DSS.0000000000002414DOI Listing

Self-Reported Eating Speed and Incidence of Gestational Diabetes Mellitus: the Japan Environment and Children's Study.

Nutrients 2020 May 2;12(5). Epub 2020 May 2.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka 5650871, Japan.

There is little evidence linking eating speed to gestational diabetes mellitus (GDM) incidence. We therefore aimed to evaluate the prospective association of eating speed with GDM incidence. Overall, 97,454 pregnant women were recruited between January 2011 and March 2014. Read More

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http://dx.doi.org/10.3390/nu12051296DOI Listing

Recombinant Methioninase Combined With Tumor-targeting A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma.

Anticancer Res 2020 May;40(5):2515-2523

AntiCancer, Inc., San Diego, CA, U.S.A.

Background/aim: Dedifferentiated liposarcoma (DDLPS) is associated with a poor survival rate even with multi-modality treatment. In the present study, we evaluated the efficacy of recombinant methioninase (rMETase) combined with tumor-targeting Salmonella typhimurium (S. typhimurium) A1-R against a doxorubicin-resistant DDLPS in a patient-derived orthotopic xenograft (PDOX) mouse model. Read More

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http://dx.doi.org/10.21873/anticanres.14222DOI Listing

Consistency of Trans-Abdominal and Water-Immersion Ultrasound Images of Diseased Intestinal Segments in Crohn's Disease.

Diagnostics (Basel) 2020 Apr 29;10(5). Epub 2020 Apr 29.

Inflammatory Bowel Disease Center, Yokohama City University Medical Center, Yokohama 232-0024, Japan.

The aim of this study is to clarify whether trans-abdominal ultrasound (TAUS) can reflect actual intestinal conditions in Crohn's disease (CD) as effectively as water-immersion ultrasound (WIUS) does. This retrospective study enrolled 29 CD patients with 113 intestinal lesions. Five ultrasound (US) parameters (distinct presence/indistinct presence/disappearance of wall stratification in the submucosal and mucosal layers; thickened submucosal layer; irregular mucosal surface; increased fat wrapping around the bowel wall; and fistula signs) that may indicate different states in CD were determined by TAUS and WIUS for the same lesion. Read More

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http://dx.doi.org/10.3390/diagnostics10050267DOI Listing

Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model.

Am J Physiol Gastrointest Liver Physiol 2020 Jun 4;318(6):G989-G999. Epub 2020 May 4.

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Nonalcoholic fatty liver disease (NAFLD) is associated with testosterone deficiency. However, NAFLD patients generally do not respond to treatment with testosterone alone. We investigated the innate immune mechanisms underlying the effects of treatment with testosterone alone, estrogen alone, or combined testosterone and estrogen on high-fat diet (HFD)-induced NAFLD due to testosterone deficiency. Read More

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http://dx.doi.org/10.1152/ajpgi.00310.2019DOI Listing

Remission of Kimura Disease With Carotid Hypervascularization After Cyclosporine Treatment.

Dermatol Pract Concept 2020 3;10(2):e2020030. Epub 2020 Apr 3.

Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Italy.

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http://dx.doi.org/10.5826/dpc.1002a30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190463PMC

High RAD18 Expression is Associated with Disease Progression and Poor Prognosis in Patients with Gastric Cancer.

Ann Surg Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.

Background: RAD18 plays an important role in DNA damage repair by inducing monoubiquitinated PCNA (mUB-PCNA) in both cancer and normal tissues. Previous studies have not determined the significance of RAD18 expression in clinical gastric cancer (GC) samples. Thus, this study aimed to clarify the expression and functional significance of RAD18 in GC. Read More

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http://dx.doi.org/10.1245/s10434-020-08518-2DOI Listing

Changes in Whole-Blood microRNA Profiles during the Onset and Treatment Process of Cerebral Infarction: A Human Study.

Int J Mol Sci 2020 Apr 28;21(9). Epub 2020 Apr 28.

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.

Circulating miRNA species are promising symptom markers for various diseases, including cardiovascular disease. However, studies regarding their role in the treatment process are limited, especially concerning cerebral infarction. This study aimed to extract miRNA markers to investigate whether they reflect both onset and treatment process of cerebral infarction. Read More

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http://dx.doi.org/10.3390/ijms21093107DOI Listing

Perinatal Determinants of Child Maltreatment in Japan.

Front Pediatr 2020 15;8:143. Epub 2020 Apr 15.

Department of Maternal Fetal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.

Child maltreatment induces significant health problems, both during childhood and into adulthood. To prevent child maltreatment, it is important to detect perinatal risk factors for earlier intervention. The aim of this study was to evaluate the perinatal risk factors associated with child maltreatment during pregnancy. Read More

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http://dx.doi.org/10.3389/fped.2020.00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174719PMC

A pilot study of adjuvant chemotherapy with carboplatin and oral S-1 for patients with completely resected stage II to IIIA non-small cell lung cancer.

Thorac Cancer 2020 Apr 29. Epub 2020 Apr 29.

Department of Respiratory Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Background: Adjuvant chemotherapy with platinum-based regimens for completely resected early-stage non-small cell lung cancer (NSCLC) provides overall survival benefit in several clinical trials.

Objectives: We conducted this prospective study to evaluate the efficacy and safety of adjuvant chemotherapy with carboplatin and S-1 for patients with completely resected stage II to IIIA NSCLC.

Methods: Patients with completely resected stage IIA to IIIA NSCLC were treated with four cycles of carboplatin with area under the concentration time curve of 5 mg/mL/min on day 1 plus S-1 at 80-120 mg/bodyweight per day for two weeks, followed by one-week rest as adjuvant chemotherapy. Read More

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http://dx.doi.org/10.1111/1759-7714.13444DOI Listing

Clinical impact of advanced chronic kidney disease in patients with non-HIV pulmonary cryptococcosis.

BMC Pulm Med 2020 Apr 29;20(1):116. Epub 2020 Apr 29.

Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Saga Prefecture, 849-8501, Japan.

Background: Pulmonary cryptococcosis is an uncommon infectious disease that can develop in both immunocompromised and immunocompetent patients. The severity of chronic kidney disease (CKD) was reported to be one of the risk factors for pulmonary cryptococcosis, but its clinical characteristics have not been fully assessed. The purpose of this study was to clarify the clinical characteristics of advanced CKD in patients with pulmonary cryptococcosis. Read More

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http://dx.doi.org/10.1186/s12890-020-1149-3DOI Listing

Dynamic-Ventilatory Digital Radiography in Air Flow Limitation: A Change in Lung Area Reflects Air Trapping.

Respiration 2020 Apr 29:1-7. Epub 2020 Apr 29.

College of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.

Objective: The aim of this study was to determine the utility of dynamic-ventilatory digital radiography (DR) for pulmonary function assessment in patients with airflow limitation.

Methods: One hundred and eighteen patients with airflow limitation (72 patients with lung cancer before surgery, 35 patients with chronic obstructive pulmonary disease [COPD], 6 patients with asthma, and 5 patients with asthma-COPD overlap syndrome) were assessed with dynamic-ventilatory DR. The patients were instructed to inhale and exhale slowly and maximally. Read More

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http://dx.doi.org/10.1159/000506881DOI Listing

Analytical and clinical validation of rapid chemiluminescence enzyme immunoassay for urinary thioredoxin, an oxidative stress-dependent early biomarker of acute kidney injury.

Clin Chim Acta 2020 Apr 26;507:271-279. Epub 2020 Apr 26.

Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Background: Oxidative stress is now recognized to be an important therapeutic target in kidney diseases. However, there are currently no biomarkers that can be used clinically to diagnose renal oxidative stress.

Methods: A rapid assay system for urinary thioredoxin 1, an oxidative stress-dependent biomarker of acute kidney injury (AKI), was developed as a chemiluminescence enzyme immunoassay and validated analytically and clinically. Read More

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http://dx.doi.org/10.1016/j.cca.2020.04.025DOI Listing

Morphometric changes and imaging findings of diffuse liver disease in relation to intrahepatic hemodynamics.

Jpn J Radiol 2020 Apr 28. Epub 2020 Apr 28.

Department of Radiology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Diffuse hepatic diseases have a variety of etiologies, with each showing characteristic morphometric changes. These changes are closely related to micro- and macro-level intrahepatic hemodynamics, in addition to the specific underlying pathophysiology. Short-term disorders in intrahepatic hemodynamics caused by each pathophysiological condition are compensated for by the balance of blood perfusion systems using potential trans-sinusoidal, transversal, and transplexal routes of communication (micro-hemodynamics), while long-term alterations to the intrahepatic hemodynamics result in an increase in total hepatic vascular resistance. Read More

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http://dx.doi.org/10.1007/s11604-020-00978-6DOI Listing

Switching from first or second generation EGFR-TKI to osimertinib in mutation-positive NSCLC.

Lung Cancer Manag 2020 Mar 19;9(2):LMT29. Epub 2020 Mar 19.

Department of Thoracic Oncology, Osaka International Cancer Institute 3-1-69 Otemae, Chio-ku, Osaka 541-8567, Japan.

Aim: We evaluated the efficacy of a novel switch protocol for EGFR-TKIs for mutation-positive NSCLC.

Materials & Methods: Clinical records were collected from the patients who had received one of two sequential combination strategies of EGFR-TKIs: Salvage use of osimertinib for -mediated acquired resistance to an prior EGFR-TKI or switch use of osimertinib where an EGFR-TKI was switched to osimertinib before disease progression.

Results: Progression-free survival of osimertinib and time from the start of treatment until progression to osimertinib was comparable between the salvage use and switch use of osimertinib. Read More

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http://dx.doi.org/10.2217/lmt-2020-0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186852PMC

High Serum Interleukin-6 is Associated With Severe Progression of Rheumatoid Arthritis and Increased Treatment Response Differentiating Sarilumab from Adalimumab or Methotrexate in a Post Hoc Analysis.

Arthritis Rheumatol 2020 Apr 28. Epub 2020 Apr 28.

Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA.

Objectives: The development of biomarkers to guide treatment decisions is a major research focus in rheumatoid arthritis (RA). Patients with RA have elevated interleukin-6 (IL-6) levels; however, the utility of IL-6 as a predictor of treatment response is unclear. The objective of this study was to investigate, by post hoc analysis, whether baseline IL-6 levels could predict sarilumab treatment responses in two phase III studies. Read More

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http://dx.doi.org/10.1002/art.41299DOI Listing

Dynamics of effector and naïve Regulatory T cells throughout pregnancy.

J Reprod Immunol 2020 Apr 19;140:103135. Epub 2020 Apr 19.

Department of obstetrics and gynecology, Osaka university, 1-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Regulatory T (Treg) cells are a specialized subset of T cells possessing immunosuppressive functions indispensable for the maintenance of self-tolerance and pregnancy. However, how functional Treg cells dynamically change and are engaged in feto-maternal tolerance during human pregnancy is still unclear. Recent studies have shown that functionally distinct and immunosuppressive subsets of Treg cells, i. Read More

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http://dx.doi.org/10.1016/j.jri.2020.103135DOI Listing

Molecular dissection of ALS-linked TDP-43 - involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.

FEBS Lett 2020 Apr 27. Epub 2020 Apr 27.

Department of Biological Science, Graduate School of Science, and Faculty of Science Osaka University, Toyonaka, Japan.

TDP-43 is the major pathogenic protein of amyotrophic lateral sclerosis (ALS). Previously, we identified that TDP-43 interacts with G-quadruplex (G4)-containing RNA and is involved in their long-distance transport in neurons. For the molecular dissection of the TDP-43 and G4-RNA interaction, we analyzed it here in vitro and in cultured cells using a set of 10 mutant TDP-43 proteins from familial and sporadic ALS patients as well as using the TDP-43 C-terminal Gly-rich domain alone. Read More

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http://dx.doi.org/10.1002/1873-3468.13800DOI Listing

An evaluation of hepatocellular carcinoma practice guidelines from a radiation oncology perspective.

Radiother Oncol 2020 Apr 2;148:73-81. Epub 2020 Apr 2.

Department of Radiation Oncology, Yonsei Cancer Center, Seoul, Republic of Korea. Electronic address:

Introduction: External beam radiotherapy (EBRT) is actively used for hepatocellular carcinoma (HCC) treatment in clinical practice but has not got attention in several guidelines owing to the lack of high-level evidences. We evaluated HCC treatment guidelines from the radiation oncology perspective using the Appraisal of Guidelines for Research and Evaluation (AGREE II) model, to provide information to choose suitable guidelines and for future guidelines developments.

Methods: Guidelines and consensuses for HCC management involving EBRT that have been published until May 2019 were included. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.03.027DOI Listing

Serial MRI alterations of pediatric patients with beta-propeller protein associated neurodegeneration (BPAN).

J Neuroradiol 2020 Apr 23. Epub 2020 Apr 23.

Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.

Background And Purpose: Beta-propeller protein-associated neurodegeneration (BPAN) is one subtype of neurodegeneration with brain iron accumulation. It is difficult to diagnose BPAN due to the non-specificity of their clinical findings and neuroimaging in early childhood. We experienced four pediatric patients with serial brain MRI and evaluated the alteration of the findings through their course. Read More

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http://dx.doi.org/10.1016/j.neurad.2020.04.002DOI Listing

1Comparison in effects by three kinds of glucose-lowering drugs on nonalcoholic fatty liver disease in cases with type 2 diabetes: A randomized, open-label, 3-arm active-control study.

J Diabetes Investig 2020 Apr 24. Epub 2020 Apr 24.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan.

Introduction: Nonalcoholic fatty liver disease (NAFLD) is often observed in subjects with type 2 diabetes mellitus (T2DM), and it is known that the presence of T2DM leads to the aggravation of NAFLD. The aim of this study is to compare the possible effects of three kinds of oral hypoglycemic agents on NAFLD in subjects with T2DM.

Materials And Methods: We conducted a prospective clinical trial (a randomized and open-label study) in subjects with T2DM and NAFLD. Read More

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http://dx.doi.org/10.1111/jdi.13279DOI Listing

Reduced expression of exosomal miR‑29s in peritoneal fluid is a useful predictor of peritoneal recurrence after curative resection of gastric cancer with serosal involvement.

Oncol Rep 2020 Apr 17;43(4):1081-1088. Epub 2020 Feb 17.

Center for Clinical Research, Jichi Medical University, Shimotsuke, Tochigi 329‑0498, Japan.

The peritoneal surface is the most frequent site of metastasis disease in patients with gastric cancer. Even after curative surgery and adjuvant chemotherapy, peritoneal recurrences often develop. Exosomes play pivotal roles in tumor metastasis via the transfer of microRNAs (miRNAs). Read More

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http://dx.doi.org/10.3892/or.2020.7505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057811PMC

Effective Treatment with Tocilizumab in a Rheumatoid Arthritis Patient Complicated with Human T-cell Leukemia Virus Type 1-associated Myelopathy: A Case Report.

Intern Med 2020 Apr 23. Epub 2020 Apr 23.

Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Japan.

A 61-year-old woman with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and interstitial pneumonia (IP) was admitted to our hospital. She complained of sicca symptoms, polyarthralgia, and swollen joints. She was diagnosed with rheumatoid arthritis (RA) and Sjogren's syndrome. Read More

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http://dx.doi.org/10.2169/internalmedicine.4455-20DOI Listing

Angiolymphoid hyperplasia with eosinophilia in the lungs: a complex name for an innocuous disease?

J Bras Pneumol 2020 Apr 22;46(3):e20190365. Epub 2020 Apr 22.

. Serviço de Anatomia Patológica, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

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http://dx.doi.org/10.36416/1806-3756/e20190365DOI Listing

Urinary and serum oxysterols in children: developmental pattern and potential biomarker for pediatric liver disease.

Sci Rep 2020 Apr 21;10(1):6752. Epub 2020 Apr 21.

Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Few reports describe oxysterols in healthy children or in children with liver disease. We aimed to determine whether developmental changes in urinary and serum oxysterols occur during childhood, and to assess whether oxysterols might be biomarkers for pediatric liver disease. Healthy children enrolled as subjects (36 and 35 for urine and serum analysis, respectively) included neonates, infants, preschoolers, and school-age children, studied along with 14 healthy adults and 8 children with liver disease. Read More

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http://dx.doi.org/10.1038/s41598-020-63758-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174363PMC

Case report of API2-MALT1 fusion-positive MALT lymphoma arising from bilateral submandibular glands with no evidence of autoimmune syndromes.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Apr 18. Epub 2020 Apr 18.

Oral and Maxillofacial Surgery, Ogaki Municipal Hospital, Ogaki, Japan.

Mucosa-associated lymphoid tissue (MALT) lymphoma arising from the salivary glands is usually associated with chronic infection or autoimmune syndromes, such as primary Sjogren syndrome. The occurrence of t(11;18)/API2-MALT1 is rare in salivary MALT lymphoma. Here we describe a case of API2-MALT1 fusion-positive MALT lymphoma of the bilateral submandibular glands with no evidence of autoimmune syndromes. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.12.018DOI Listing

Establishment of a clinician-led guideline on the diagnosis and treatment of Hirayama disease using a modified Delphi technique.

Clin Neurophysiol 2020 Jun 16;131(6):1311-1319. Epub 2020 Mar 16.

Department of Orthopedics, Huashan Hospital, Fudan University Shanghai 200040, China. Electronic address:

Objective: To establish a clinician-led guideline for the diagnosis and treatment of Hirayama disease (HD) using a modified Delphi technique.

Methods: Based on a combination of a systematic review and opinion of ten experts, a protocol for the consensus of the diagnosis, treatment and follow-up assessment of HD was established. A modified 3-round Delphi survey was then performed by more than 40 panelists from various countries of the world. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.02.022DOI Listing