43,379 results match your criteria Kimura Disease


Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa associated polyomavirus.

Microbiol Immunol 2018 Dec 11. Epub 2018 Dec 11.

Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.

Trichodysplasia spinulosa associated polyomavirus (TSPyV), a newly identified polyomavirus has been implicated as a causative agent of trychodysplasia spinulosa (TS), a rare proliferative skin disease in severly immunocompromised hosts. The diagnosis using monoclonal antibodies (mAbs) has been provided as a promising tool as it offers high specificity towards specific antigen. Till there is no good mAb available for diagnosis of TS disease. Read More

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December 2018
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Comparison between instantaneous wave-free ratio versus morphometric assessments by intracoronary imaging.

Heart Vessels 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Anatomical measurements obtained by intracoronary imaging devices are reported to correlate significantly with fractional flow reserve (FFR). Instantaneous wave-free ratio (iFR) is a nonhyperemic index of stenosis severity with discordant reports regarding its accuracy in relation to FFR. There is no information on the correlation of iFR with measurements derived from intracoronary imaging devices. Read More

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December 2018

Thoracic endografting increases cardiac afterload and leads to left ventricular hypertrophy in dogs.

Eur J Cardiothorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiovascular Surgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Objectives: Aortic endografting can cause aortic stiffening. We aimed to determine the chronic effect of thoracic endografting on cardiac afterload, function and remodelling.

Methods: Eleven dogs were included, and all except 1 was successfully assessed [endograft, n = 5; sham operation (control), n = 5]. Read More

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December 2018

Enzymatic characteristics of two adenylate kinases, AdkA and AdkB, from Myxococcus xanthus.

J Biochem 2018 Dec 7. Epub 2018 Dec 7.

Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Miki-cho, Kagawa, Japan.

Adenylate kinase (Adk) plays a critical role in energy metabolism and adaptation of bacteria to environmental stresses. We have previously shown that Myxococcus xanthus expresses polyphosphate kinase 1 (Ppk1) that also has Adk activity in the absence of polyphosphates. In this study, we investigated the Adk activity of the other two M. Read More

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December 2018

The Effectiveness of Hepatic Arterial Infusion Chemotherapy with 5-Fluorouracil/Cisplatin and Systemic Chemotherapy with Ramucirumab in Alpha-Fetoprotein-Producing Gastric Cancer with Multiple Liver Metastases.

Case Rep Oncol Med 2018 11;2018:5402313. Epub 2018 Nov 11.

Department of Pathology, Kurume University Hospital, Kurume, Japan.

Alpha-fetoprotein- (AFP-) producing gastric cancer (AFPGC) is characterized by a high incidence of liver and lymph node metastases and poor prognosis. Although several case reports have described successful multidisciplinary treatment, there are currently no standard therapies for AFPGC. A 57-year-old man presented with upper abdominal pain. Read More

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November 2018

Epigenetic silencing of induces senescence of intestinal epithelial organoids during the process of aging.

NPJ Aging Mech Dis 2019 1;5. Epub 2018 Dec 1.

Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, 1-5-30 Shiba-kohen, Minato-ku, Tokyo, 105-8512 Japan.

To understand the molecular features underlying stem cell aging, we established intestinal epithelial organoids derived from both young and aged mice and investigated alterations in their senescence and epigenetic status. Senescence-related changes including accumulation of senescence-associated β-galactosidase and up-regulation of ( by DNA demethylation were observed in intestinal epithelial organoids derived from aged mice. We also demonstrated that the important stem cell marker was epigenetically silenced by trimethylation of histone H3 lysine 27, inducing suppression of Wnt signaling and a decrease of cell proliferation in organoids from aged mice. Read More

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December 2018

Draft Genome Sequence of Pseudomonas citronellolis LA18T, a Bacterium That Uses Levulinic Acid.

Microbiol Resour Announc 2018 Aug 9;7(5). Epub 2018 Aug 9.

Environmental Management Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan.

Pseudomonas citronellolis LA18T catabolizes levulinic acid (LA) from cellulosic biomass hydrolysate via acetyl-coenzyme A (acetyl-CoA) and propionyl-CoA. This study reports the 7.22-Mbp draft genome sequence of P. Read More

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The Rate of Venous Thromboembolism Before and After Spine Surgery as Determined with Indirect Multidetector CT.

JB JS Open Access 2018 Sep 15;3(3):e0015. Epub 2018 Aug 15.

Department of Orthopaedic Surgery, Jichi Medical University, Shimotsuke, Japan.

Background: This prospective cohort study investigated the rate of venous thromboembolism (VTE) before and after spine surgery as determined with use of indirect multidetector computed tomography (MDCT).

Methods: We performed a prospective study of 105 patients (36 women and 69 men ranging in age from 38 to 88 years) undergoing spine surgery at 2 institutions. Indirect MDCT was performed before and 3 days after surgery. Read More

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September 2018

Accelerometric outcomes of motor function related to clinical evaluations and muscle involvement in dystrophic dogs.

PLoS One 2018 11;13(12):e0208415. Epub 2018 Dec 11.

Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.

Duchenne muscular dystrophy (DMD) is an X-linked muscle disorder characterized by primary muscle degeneration. Patients with DMD reveal progressive muscle weakness leading to ambulatory dysfunction. Novel outcome measures are needed for more sensitive evaluation of therapeutic effects in clinical trials. Read More

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December 2018

Electron-tracking Compton camera imaging of technetium-95m.

PLoS One 2018 10;13(12):e0208909. Epub 2018 Dec 10.

Japan Atomic Energy Agency, Tokai, Ibaraki, Japan.

Imaging was conducted using an electron tracking-Compton camera (ETCC), which measures γ-rays with energies in the range of 200-900 keV from 95mTc. 95mTc was produced by the 95Mo(p, n)95mTc reaction on a 95Mo-enriched target. A method for recycling 95Mo-enriched molybdenum trioxide was employed, and the recycled yield of 95Mo was 70%-90%. Read More

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December 2018

A chromatin integration labelling method enables epigenomic profiling with lower input.

Nat Cell Biol 2018 Dec 10. Epub 2018 Dec 10.

Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Chromatin plays a crucial role in gene regulation, and chromatin immunoprecipitation followed by sequencing (ChIP-seq) has been the standard technique for examining protein-DNA interactions across the whole genome. However, it is difficult to obtain epigenomic information from limited numbers of cells by ChIP-seq because of sample loss during chromatin preparation and inefficient immunoprecipitation. In this study, we established an immunoprecipitation-free epigenomic profiling method named chromatin integration labelling (ChIL), which enables the amplification of genomic sequences closely associated with the target molecules before cell lysis. Read More

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December 2018

New tetrahydroquinoline and indoline compounds containing a hydroxy cyclopentenone, virantmycin B and C, produced by Streptomyces sp. AM-2504.

J Antibiot (Tokyo) 2018 Dec 10. Epub 2018 Dec 10.

Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

Two new antibiotics, designated virantmycin B (1) and C (2), were isolated from the cultured broth of Streptomyces sp. AM-2504. Compounds 1 and 2 were purified by Diaion HP-20, silica gel, and octadecylsilane chromatography, followed by high-performance liquid chromatography. Read More

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December 2018

B-type natriuretic peptide in patients with asymptomatic severe aortic stenosis.

Heart 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objectives: We sought to evaluate the prognostic impact of the B-type natriuretic peptide (BNP) levels in patients with asymptomatic severe aortic stenosis (AS), who were not referred for aortic valve replacement (AVR).

Methods: We used data from a Japanese multicentre registry, the Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis Registry, which enrolled 3815 consecutive patients with severe AS. Of those, 387 asymptomatic patients who were not referred for AVR without left ventricular dysfunction and very severe AS were subdivided into four groups based on their BNP levels (BNP<100 pg/mL, n=201; 100≤BNP<200 pg/mL, n=94; 200≤BNP<300 pg/mL, n=42 and BNP>300 pg/mL, n=50). Read More

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December 2018

Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula.

Neurology 2018 Dec 7. Epub 2018 Dec 7.

From the Departments of Functional Brain Imaging Research (H. Shinotoh, H. Shimada, K.T., S.K., M.O., Y. Kimura, S.H., M.I., N.S., T.S., M.H.) and Radiopharmaceuticals Development (M.-R.Z.), National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba; Neurology Clinic Chiba (H. Shinotoh); Kii ALS/PDC Research Center (Y. Kokubo), Mie University; Department of Neurology and Gerontology (F.N.), Graduate School of Medical Science, Kyoto Prefectural University of Medicine; Department of Psychiatry (S.K.), Nara Medical University; Division of Neurology (H.E.), Kobe University Graduate School of Medicine, Hyogo; Center for Development of Advanced Medicine for Dementia, Department of Neurology (Y. Kimura), National Institute for Geriatrics and Gerontology, Aichi; Department of Neurology (S.H.), Chiba University; and Department of Neuropathology (M.M.), Institute for Medical Science of Aging, Aichi Medical University, Japan.

Objective: To characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [C]PBB3 as ligand.

Methods: This is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Read More

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December 2018

Simultaneous three-port thoracoscopic surgery for bilateral lung cancers with a pulmonary vein anomaly: A case report.

Int J Surg Case Rep 2018 Nov 24;54:66-69. Epub 2018 Nov 24.

Department of Thoracic Surgery, Respiratory Centre, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.

Introduction: Simultaneous resection of bilateral lung cancers is technically challenging but may be preferable to a staged procedure in patients with a partial anomalous pulmonary venous connection (PAPVC) in an affected lobe. We performed single-stage resection of bilateral lung cancers in a patient with a PAPVC.

Presentation Of Case: A 73-year-old man was diagnosed as having bilateral lung cancers (right, cT3N1M0, stage IIIA and left, cT2aN0M0, stage IB). Read More

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November 2018

The effect of multiple lesions in patients with ossification of the posterior longitudinal ligament of the cervical spine.

J Orthop Sci 2018 Dec 8. Epub 2018 Dec 8.

Department of Orthopaedic Surgery, University of Toyama, Toyama, Japan.

Purpose: Ossification of the posterior longitudinal ligament of the cervical spine (cervical OPLL) is associated with the lesions at the thoracic and/or lumbar spine. Multiple spinal lesions cause additional neurological deficit, affecting the outcomes of cervical laminoplasty. This study aimed to clarify the effect of multiple lesions on the outcomes of cervical laminoplasty and to compare the results with data from patients without them. Read More

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December 2018

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.

Drug Metab Pharmacokinet 2018 Sep 20. Epub 2018 Sep 20.

Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. Electronic address:

This study aimed to elucidate the impact of OATP1B1 genotype (*1b/*1b, *1b/*15, and *15/*15) on plasma concentrations of endogenous OATP1B1 substrates. Healthy volunteers with OATP1B1 *1b/*1b (n = 10), *1b/*15 (n = 7), or *15/*15 (n = 2) received oral administration of a cocktail of statins (atorvastatin, pitavastatin, rosuvastatin, and fluvastatin). Mean area under the plasma concentration of atorvastatin, pitavastatin, and rosuvastatin in OATP1B1 *15/*15 were 2. Read More

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September 2018

Accuracy of non-invasive stress testing in women and men with angina in the absence of obstructive coronary artery disease.

Int J Cardiol 2018 Oct 23. Epub 2018 Oct 23.

Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Stanford, CA, USA. Electronic address:

Objective: While >20% of patients presenting to the cardiac catheterization laboratory with angina have no obstructive coronary artery disease (CAD), a majority (77%) have an occult coronary abnormality (endothelial dysfunction, microvascular dysfunction (MVD), and/or a myocardial bridge (MB)). There are little data regarding the ability of noninvasive stress testing to identify these occult abnormalities in patients with angina in the absence of obstructive CAD.

Methods: We retrospectively evaluated 155 patients (76. Read More

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October 2018

Suture fistula revisited for long gap esophageal atresia.

J Pediatr Surg 2018 Nov 11. Epub 2018 Nov 11.

Division of Pediatric Surgery, Department of Surgery, Boonshoft School of Medicine, Dayton Children's Hospital, Dayton, OH. Electronic address:

Background: Long gap esophageal atresia presents a challenge to pediatric surgeons due to the variability in surgical management when primary anastomosis is not feasible. Mechanical traction procedures enhance tissue growth that allows early anastomosis, before delayed primary closure (DPC) would be attempted to allow for rapid oral feeding, or when operative discoveries require flexibility of the surgical plan. The Suture Fistula procedure, first published by Alan Shafer and Tirone David in 1974, is a simple, effective, but underutilized single-stage procedure which results in spontaneous fistulization of approximated, non-anastomosed esophageal segments using tension sutures. Read More

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November 2018

Myocardial Infarction Caused by Accelerated Plaque Formation Related to Myocardial Bridge in a Young Man.

Can J Cardiol 2018 Dec 20;34(12):1687.e13-1687.e15. Epub 2018 Aug 20.

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

A 28-year-old man without coronary risk factors was admitted to the hospital with acute coronary syndromes (ACS). The angiogram and intravascular ultrasound revealed myocardial bridge (MB) in the mid-left anterior descending artery and flow-limiting plaque located 15.4 mm proximal to MB. Read More

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December 2018

A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death.

Elife 2018 Dec 7;7. Epub 2018 Dec 7.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, United States.

Intracellular lipopolysaccharide (LPS) triggers the non-canonical inflammasome pathway, resulting in pyroptosis of innate immune cells. In addition to its well-known proinflammatory role, LPS can directly cause regression of some tumors, although the underlying mechanism has remained unknown. Here we show that secretoglobin(SCGB)3A2, a small protein predominantly secreted in airways, chaperones LPS to the cytosol through the cell surface receptor syndecan-1; this leads to pyroptotic cell death driven by caspase-11. Read More

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December 2018

Schnitzler's syndrome: A female elderly case presenting intractable non-pruritic febrile urticarial rush.

Asian Pac J Allergy Immunol 2018 Dec 9. Epub 2018 Dec 9.

Graduate School of Medical Sciences, Department of Dermatology, Kyushu University, Fukuoka, Japan.

Schnitzler's syndrome is an acquired autoinflammatory disease characterized by chronic urticarial rash and monoclonal gammopathy (predominantly IgM type). A 75-year-old Japanese woman complained of high fever and non-pruritic urticarial rash appearing almost every day for 3 years. Her abnormal laboratory data included leukocytosis and neutrophilia with elevated erythrocyte sedimentation rate and C-reactive protein level. Read More

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December 2018

Magnetic Tunnel Junctions with a Nearly Zero Moment Manganese Nanolayer with Perpendicular Magnetic Anisotropy.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

National Institute of Advanced Industrial Science and Technology (AIST), Spintronics Research Center , Tsukuba 305-8568 , Japan.

A magnetic nanolayer with a perpendicular magnetic easy axis and negligible magnetization is demonstrated. Even though a manganese metal is antiferromagnetic in bulk form, a few manganese monolayers grown on a paramagnetic ordered alloy template and capped by an oxide layer exhibit a strong perpendicular magnetic anisotropy field exceeding 19 T as well as a negligible magnetization of 25 kA/m. The nanolayer shows tunnel magnetoresistance. Read More

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December 2018

Investigation of tolerability and quality of life for carboplatin-based chemotherapy in an elderly urothelial carcinoma patient undergoing hemodialysis: a case report.

J Pharm Health Care Sci 2018 29;4:29. Epub 2018 Nov 29.

1Department of Pharmacy, Nagoya City University Hospital, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8602 Japan.

Background: To our knowledge, no studies have evaluated the safety of carboplatin (CBDCA)-based chemotherapy in hemodialysis patients > 80 years-old. In addition, the impact of CBDCA-based chemotherapy on such elderly patients' quality of life (QOL) is unknown. We report a case of gemcitabine plus CBDCA chemotherapy treatment in an 81-year-old man with metastatic urothelial carcinoma undergoing hemodialysis. Read More

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November 2018

A 17-year-old woman with a solitary, mixed squamous cell and glandular papilloma of the bronchus.

Respirol Case Rep 2019 Feb 30;7(2):e00393. Epub 2018 Nov 30.

Department of Respiratory Medicine Kyorin University School of Medicine Tokyo Japan.

A 17-year-old woman was referred to our hospital due to cough on exertion and right chest pain over the previous two months, together with bloody sputum over the previous week. Chest X-ray demonstrated a nodule measuring 3 cm in diameter in the right middle lung field. On repeated bronchoscopy, the tumour was recognized as a rapidly growing intra-bronchial protruded tumour at the orifice of the right B8. Read More

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February 2019

The performance of an in vitro skin sensitisation test, IL-8 Luc assay (OECD442E), and the integrated approach with direct peptide reactive assay (DPRA).

J Toxicol Sci 2018 ;43(12):741-749

Department of Dermatology, Tohoku University Graduate School of Medicine.

In all current in vitro skin sensitisation assays, DMSO is used to dissolve water-insoluble chemicals. However, our previous study suggested the superiority of the modified IL-8 Luc assay (mIL-8 Luc), in which X-VIVO 15 is used to dissolve chemicals, over the original assay using DMSO (oIL-8 Luc). In this study, to confirm the superiority of the mIL-8 Luc, we first increased the number of chemicals examined and demonstrated the superiority of the mIL-8 Luc, in which the mIL-8 Luc provided 87. Read More

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January 2018

Long-term prognosis of Japanese patients with biologicnaïve Crohn's disease treated with anti-tumor necrosis factor-α antibodies.

Intest Res 2018 Dec 3. Epub 2018 Dec 3.

Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: Few reports have described the long-term treatment outcomes of the anti-tumor necrosis factor-α antibody for Japanese Crohn's disease (CD) patients. The aim of this study was to evaluate them and clarify the clinical factors that affect the long-term prognosis of the anti-tumor necrosis factor-α treatments.

Methods: This was a retrospective, observational, single-center cohort study. Read More

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December 2018
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Beyond resumption of the Japanese Government's recommendation of the HPV vaccine.

Lancet Oncol 2018 Dec;19(12):1563-1564

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.

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December 2018
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A case of sinobronchial syndrome progressing to diffuse panbronchiolitis despite low-dose, long-term macrolide therapy.

J Thorac Dis 2018 Oct;10(10):E727-E729

Department of Hematology/Respiratory-Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, Japan.

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October 2018

3D microdevices that perform sample purification and multiplex qRT-PCR for early cancer detection with confirmation of specific RNAs.

Sci Rep 2018 Nov 30;8(1):17480. Epub 2018 Nov 30.

The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.

MicroRNA expression analysis is an important screening tool for the early detection of cancer. In this study, we developed two portable three-dimensional microdevices for multiple singleplex RNA expression analysis by microRNA purification and qRT-PCR as a prototype for point-of-care testing. These microdevices are composed of several types of modules termed 'chemical IC chips'. Read More

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November 2018

Novel Strategy for the Systemic Delivery of Furosemide Based on a New Drug Transport Mechanism.

Biol Pharm Bull 2018 ;41(12):1769-1777

Department of Pharmaceutical Technology, Kobe Pharmaceutical University.

We reported a novel transport mechanism of curcumin, independent of improved solubility, which involved direct contact of amorphous solid particles with the cell membrane. This mechanism has potential as a novel systemic delivery system of poorly water-soluble drugs. In this study, the transport mechanism of furosemide (FUR), which is transported by the same novel mechanism, was examined. Read More

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January 2018

Effect of Controlled Nucleation of Ice Crystals on the Primary Drying Stage during Lyophilization.

Chem Pharm Bull (Tokyo) 2018 ;66(12):1122-1130

Graduate School of Environmental and Life Science, Okayama University.

The freezing stage cannot be directly controlled, which leads to variation in product quality and low productivity during the lyophilization process. Our objective was to establish a robust design space for the primary drying stage using ice nucleation control based on the pressurization and depressurization technique. We evaluated the specific surface area (SSA), water content, scanning electron microscopy (SEM) images, and water vapor transfer resistance of the dried layer (R) of the products. Read More

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January 2018
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A Phase II Study of Tri-weekly Low-dose Nab-paclitaxel Chemotherapy for Patients with Advanced Gastric Cancer.

Anticancer Res 2018 Dec;38(12):6911-6917

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Background/aim: Nanoparticle albumin-bound (nab)-paclitaxel has demonstrated antitumor activity against advanced gastric cancer. However, gastric cancer patients can be difficult to treat with the recommended dose because of the high incidence of adverse toxicities. The aim of this study was to evaluate the safety and effectiveness of low-dose nab-paclitaxel in a multicenter, single-arm, phase II study. Read More

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December 2018

Lusutrombopag Reduces Need for Platelet Transfusion in Patients With Thrombocytopenia Undergoing Invasive Procedures.

Clin Gastroenterol Hepatol 2018 Nov 28. Epub 2018 Nov 28.

Institute for Gastrointestinal and Liver Diseases, Shin-yurigaoka General Hospital, Kawasaki, Japan.

Background & Aims: Platelet transfusion is used to prevent hemorrhagic events in patients with thrombocytopenia undergoing invasive procedures, but there are many disadvantages. We evaluated the efficacy and safety of lusutrombopag in patients with chronic liver disease and thrombocytopenia undergoing invasive procedures.

Methods: We performed a double-blind, parallel-group, phase 3 study of 96 patients with chronic liver disease and thrombocytopenia (platelet counts below 50,000/μL) undergoing invasive procedures from October 2013 to May 2014 at 81 centers in Japan. Read More

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November 2018

Proresolving Lipid Mediators Resolvin D1 and Protectin D1 Isomer Attenuate Neointimal Hyperplasia in the Rat Carotid Artery Balloon Injury Model.

J Surg Res 2019 Jan 18;233:104-110. Epub 2018 Aug 18.

Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Specialized proresolving mediators from ω-3 polyunsaturated fatty acid may control resolution of inflammation. We evaluated the influence of two specialized proresolving mediators, resolvin D1 (RvD1) and protectin D1 isomer (PD1 iso) on neointimal hyperplasia after balloon injury.

Materials And Methods: Sprague Dawley male rats at 12-14 wk of age were injured as a model of balloon angioplasty. Read More

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January 2019

Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration.

EBioMedicine 2018 Nov 27. Epub 2018 Nov 27.

Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan; RIKEN Program for Drug Discovery and Medical Technology Platforms (DMP), Yokohama 230-0045, Japan. Electronic address:

Background: We have previously reported that xeno-transplanted human ESC-derived retinas are able to mature in the immunodeficient retinal degeneration rodent models, similar to allo-transplantations using mouse iPSC-derived retina. The photoreceptors in the latter developed outer segments and formed synapses with host bipolar cells, driving light responses of host retinal ganglion cells. In view of clinical application, here we further confirmed the competency of human iPSC-derived retina (hiPSC-retina) to mature in the degenerated retinas of rat and monkey models. Read More

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November 2018

Combination of the Searches for Pair-Produced Vectorlike Partners of the Third-Generation Quarks at sqrt[s]=13  TeV with the ATLAS Detector.

Authors:
M Aaboud G Aad B Abbott O Abdinov B Abeloos D K Abhayasinghe S H Abidi O S AbouZeid N L Abraham H Abramowicz H Abreu Y Abulaiti B S Acharya S Adachi L Adam L Adamczyk J Adelman M Adersberger A Adiguzel T Adye A A Affolder Y Afik C Agheorghiesei J A Aguilar-Saavedra F Ahmadov G Aielli S Akatsuka T P A Åkesson E Akilli A V Akimov G L Alberghi J Albert P Albicocco M J Alconada Verzini S Alderweireldt M Aleksa I N Aleksandrov C Alexa T Alexopoulos M Alhroob B Ali G Alimonti J Alison S P Alkire C Allaire B M M Allbrooke B W Allen P P Allport A Aloisio A Alonso F Alonso C Alpigiani A A Alshehri M I Alstaty B Alvarez Gonzalez D Álvarez Piqueras M G Alviggi B T Amadio Y Amaral Coutinho A Ambler L Ambroz C Amelung D Amidei S P Amor Dos Santos S Amoroso C S Amrouche C Anastopoulos L S Ancu N Andari T Andeen C F Anders J K Anders K J Anderson A Andreazza V Andrei C R Anelli S Angelidakis I Angelozzi A Angerami A V Anisenkov A Annovi C Antel M T Anthony M Antonelli D J A Antrim F Anulli M Aoki J A Aparisi Pozo L Aperio Bella G Arabidze J P Araque V Araujo Ferraz R Araujo Pereira A T H Arce R E Ardell F A Arduh J-F Arguin S Argyropoulos A J Armbruster L J Armitage A Armstrong O Arnaez H Arnold M Arratia O Arslan A Artamonov G Artoni S Artz S Asai N Asbah E M Asimakopoulou L Asquith K Assamagan R Astalos R J Atkin M Atkinson N B Atlay K Augsten G Avolio R Avramidou M K Ayoub A M Azoulay G Azuelos A E Baas M J Baca H Bachacou K Bachas M Backes P Bagnaia M Bahmani H Bahrasemani A J Bailey J T Baines M Bajic C Bakalis O K Baker P J Bakker D Bakshi Gupta S Balaji E M Baldin P Balek F Balli W K Balunas J Balz E Banas A Bandyopadhyay S Banerjee A A E Bannoura L Barak W M Barbe E L Barberio D Barberis M Barbero T Barillari M-S Barisits J Barkeloo T Barklow R Barnea S L Barnes B M Barnett R M Barnett Z Barnovska-Blenessy A Baroncelli G Barone A J Barr L Barranco Navarro F Barreiro J Barreiro Guimarães da Costa R Bartoldus A E Barton P Bartos A Basalaev A Bassalat R L Bates S J Batista S Batlamous J R Batley M Battaglia M Bauce F Bauer K T Bauer H S Bawa J B Beacham T Beau P H Beauchemin P Bechtle H C Beck H P Beck K Becker M Becker C Becot A Beddall A J Beddall V A Bednyakov M Bedognetti C P Bee T A Beermann M Begalli M Begel A Behera J K Behr A S Bell G Bella L Bellagamba A Bellerive M Bellomo P Bellos K Belotskiy N L Belyaev O Benary D Benchekroun M Bender N Benekos Y Benhammou E Benhar Noccioli J Benitez D P Benjamin M Benoit J R Bensinger S Bentvelsen L Beresford M Beretta D Berge E Bergeaas Kuutmann N Berger L J Bergsten J Beringer S Berlendis N R Bernard G Bernardi C Bernius F U Bernlochner T Berry P Berta C Bertella G Bertoli I A Bertram G J Besjes O Bessidskaia Bylund M Bessner N Besson A Bethani S Bethke A Betti A J Bevan J Beyer R Bi R M B Bianchi O Biebel D Biedermann R Bielski K Bierwagen N V Biesuz M Biglietti T R V Billoud M Bindi A Bingul C Bini S Biondi M Birman T Bisanz J P Biswal C Bittrich D M Bjergaard J E Black K M Black T Blazek I Bloch C Blocker A Blue U Blumenschein Dr Blunier G J Bobbink V S Bobrovnikov S S Bocchetta A Bocci D Boerner D Bogavac A G Bogdanchikov C Bohm V Boisvert P Bokan T Bold A S Boldyrev A E Bolz M Bomben M Bona J S Bonilla M Boonekamp A Borisov G Borissov J Bortfeldt D Bortoletto V Bortolotto D Boscherini M Bosman J D Bossio Sola K Bouaouda J Boudreau E V Bouhova-Thacker D Boumediene C Bourdarios S K Boutle A Boveia J Boyd D Boye I R Boyko A J Bozson J Bracinik N Brahimi A Brandt G Brandt O Brandt F Braren U Bratzler B Brau J E Brau W D Breaden Madden K Brendlinger L Brenner R Brenner S Bressler B Brickwedde D L Briglin D Britton D Britzger I Brock R Brock G Brooijmans T Brooks W K Brooks E Brost J H Broughton P A Bruckman de Renstrom D Bruncko A Bruni G Bruni L S Bruni S Bruno B H Brunt M Bruschi N Bruscino P Bryant L Bryngemark T Buanes Q Buat P Buchholz A G Buckley I A Budagov F Buehrer M K Bugge O Bulekov D Bullock T J Burch S Burdin C D Burgard A M Burger B Burghgrave K Burka S Burke I Burmeister J T P Burr V Büscher E Buschmann P Bussey J M Butler C M Buttar J M Butterworth P Butti W Buttinger A Buzatu A R Buzykaev G Cabras S Cabrera Urbán D Caforio H Cai V M M Cairo O Cakir N Calace P Calafiura A Calandri G Calderini P Calfayan G Callea L P Caloba S Calvente Lopez D Calvet S Calvet T P Calvet M Calvetti R Camacho Toro S Camarda P Camarri D Cameron R Caminal Armadans C Camincher S Campana M Campanelli A Camplani A Campoverde V Canale M Cano Bret J Cantero T Cao Y Cao M D M Capeans Garrido I Caprini M Caprini M Capua R M Carbone R Cardarelli F C Cardillo I Carli T Carli G Carlino B T Carlson L Carminati R M D Carney S Caron E Carquin S Carrá G D Carrillo-Montoya D Casadei M P Casado A F Casha D W Casper R Castelijn F L Castillo V Castillo Gimenez N F Castro A Catinaccio J R Catmore A Cattai J Caudron V Cavaliere E Cavallaro D Cavalli M Cavalli-Sforza V Cavasinni E Celebi F Ceradini L Cerda Alberich A S Cerqueira A Cerri L Cerrito F Cerutti A Cervelli S A Cetin A Chafaq D Chakraborty S K Chan W S Chan Y L Chan J D Chapman B Chargeishvili D G Charlton C C Chau C A Chavez Barajas S Che A Chegwidden S Chekanov S V Chekulaev G A Chelkov M A Chelstowska C Chen C H Chen H Chen J Chen J Chen S Chen S J Chen X Chen Y Chen Y-H Chen H C Cheng H J Cheng A Cheplakov E Cheremushkina R Cherkaoui El Moursli E Cheu K Cheung L Chevalier V Chiarella G Chiarelli G Chiodini A S Chisholm A Chitan I Chiu Y H Chiu M V Chizhov K Choi A R Chomont S Chouridou Y S Chow V Christodoulou M C Chu J Chudoba A J Chuinard J J Chwastowski L Chytka D Cinca V Cindro I A Cioară A Ciocio F Cirotto Z H Citron M Citterio A Clark M R Clark P J Clark C Clement Y Coadou M Cobal A Coccaro J Cochran H Cohen A E C Coimbra L Colasurdo B Cole A P Colijn J Collot P Conde Muiño E Coniavitis S H Connell I A Connelly S Constantinescu F Conventi A M Cooper-Sarkar F Cormier K J R Cormier L D Corpe M Corradi E E Corrigan F Corriveau A Cortes-Gonzalez M J Costa F Costanza D Costanzo G Cottin G Cowan B E Cox J Crane K Cranmer S J Crawley R A Creager G Cree S Crépé-Renaudin F Crescioli M Cristinziani V Croft G Crosetti A Cueto T Cuhadar Donszelmann A R Cukierman S Czekierda P Czodrowski M J Da Cunha Sargedas De Sousa C Da Via W Dabrowski T Dado S Dahbi T Dai F Dallaire C Dallapiccola M Dam G D'amen J Damp J R Dandoy M F Daneri N P Dang N D Dann M Danninger V Dao G Darbo S Darmora O Dartsi A Dattagupta T Daubney S D'Auria W Davey C David T Davidek D R Davis E Dawe I Dawson K De R De Asmundis A De Benedetti M De Beurs S De Castro S De Cecco N De Groot P de Jong H De la Torre F De Lorenzi A De Maria D De Pedis A De Salvo U De Sanctis M De Santis A De Santo K De Vasconcelos Corga J B De Vivie De Regie C Debenedetti D V Dedovich N Dehghanian M Del Gaudio J Del Peso Y Delabat Diaz D Delgove F Deliot C M Delitzsch M Della Pietra D Della Volpe A Dell'Acqua L Dell'Asta M Delmastro C Delporte P A Delsart D A DeMarco S Demers M Demichev S P Denisov D Denysiuk L D'Eramo D Derendarz J E Derkaoui F Derue P Dervan K Desch C Deterre K Dette M R Devesa P O Deviveiros A Dewhurst S Dhaliwal F A Di Bello A Di Ciaccio L Di Ciaccio W K Di Clemente C Di Donato A Di Girolamo G Di Gregorio B Di Micco R Di Nardo K F Di Petrillo R Di Sipio D Di Valentino C Diaconu M Diamond F A Dias T Dias Do Vale M A Diaz J Dickinson E B Diehl J Dietrich S Díez Cornell A Dimitrievska J Dingfelder F Dittus F Djama T Djobava J I Djuvsland M A B Do Vale M Dobre D Dodsworth C Doglioni J Dolejsi Z Dolezal M Donadelli J Donini A D'onofrio M D'Onofrio J Dopke A Doria M T Dova A T Doyle E Drechsler E Dreyer T Dreyer Y Du F Dubinin M Dubovsky A Dubreuil E Duchovni G Duckeck A Ducourthial O A Ducu D Duda A Dudarev A C Dudder E M Duffield L Duflot M Dührssen C Dülsen M Dumancic A E Dumitriu A K Duncan M Dunford A Duperrin H Duran Yildiz M Düren A Durglishvili D Duschinger B Dutta D Duvnjak M Dyndal S Dysch B S Dziedzic C Eckardt K M Ecker R C Edgar T Eifert G Eigen K Einsweiler T Ekelof M El Kacimi R El Kosseifi V Ellajosyula M Ellert F Ellinghaus A A Elliot N Ellis J Elmsheuser M Elsing D Emeliyanov A Emerman Y Enari J S Ennis M B Epland J Erdmann A Ereditato S Errede M Escalier C Escobar O Estrada Pastor A I Etienvre E Etzion H Evans A Ezhilov M Ezzi F Fabbri L Fabbri V Fabiani G Facini R M Faisca Rodrigues Pereira R M Fakhrutdinov S Falciano P J Falke S Falke J Faltova Y Fang M Fanti A Farbin A Farilla E M Farina T Farooque S Farrell S M Farrington P Farthouat F Fassi P Fassnacht D Fassouliotis M Faucci Giannelli A Favareto W J Fawcett L Fayard O L Fedin W Fedorko M Feickert S Feigl L Feligioni C Feng E J Feng M Feng M J Fenton A B Fenyuk L Feremenga J Ferrando A Ferrari P Ferrari R Ferrari D E Ferreira de Lima A Ferrer D Ferrere C Ferretti F Fiedler A Filipčič F Filthaut K D Finelli M C N Fiolhais L Fiorini C Fischer W C Fisher N Flaschel I Fleck P Fleischmann R R M Fletcher T Flick B M Flierl L M Flores L R Flores Castillo F M Follega N Fomin G T Forcolin A Formica F A Förster A C Forti A G Foster D Fournier H Fox S Fracchia P Francavilla M Franchini S Franchino D Francis L Franconi M Franklin M Frate M Fraternali A N Fray D Freeborn S M Fressard-Batraneanu B Freund W S Freund E M Freundlich D C Frizzell D Froidevaux J A Frost C Fukunaga E Fullana Torregrosa T Fusayasu J Fuster O Gabizon A Gabrielli A Gabrielli G P Gach S Gadatsch P Gadow G Gagliardi L G Gagnon C Galea B Galhardo E J Gallas B J Gallop P Gallus G Galster R Gamboa Goni K K Gan S Ganguly J Gao Y Gao Y S Gao C García J E García Navarro J A García Pascual M Garcia-Sciveres R W Gardner N Garelli V Garonne K Gasnikova A Gaudiello G Gaudio I L Gavrilenko A Gavrilyuk C Gay G Gaycken E N Gazis C N P Gee J Geisen M Geisen M P Geisler K Gellerstedt C Gemme M H Genest C Geng S Gentile S George D Gerbaudo G Gessner S Ghasemi M Ghasemi Bostanabad M Ghneimat B Giacobbe S Giagu N Giangiacomi P Giannetti A Giannini S M Gibson M Gignac D Gillberg G Gilles D M Gingrich M P Giordani F M Giorgi P F Giraud P Giromini G Giugliarelli D Giugni F Giuli M Giulini S Gkaitatzis I Gkialas E L Gkougkousis P Gkountoumis L K Gladilin C Glasman J Glatzer P C F Glaysher A Glazov M Goblirsch-Kolb J Godlewski S Goldfarb T Golling D Golubkov A Gomes R Goncalves Gama R Gonçalo G Gonella L Gonella A Gongadze F Gonnella J L Gonski S González de la Hoz S Gonzalez-Sevilla L Goossens P A Gorbounov H A Gordon B Gorini E Gorini A Gorišek A T Goshaw C Gössling M I Gostkin C A Gottardo C R Goudet D Goujdami A G Goussiou N Govender C Goy E Gozani I Grabowska-Bold P O J Gradin E C Graham J Gramling E Gramstad S Grancagnolo V Gratchev P M Gravila F G Gravili C Gray H M Gray Z D Greenwood C Grefe K Gregersen I M Gregor P Grenier K Grevtsov N A Grieser J Griffiths A A Grillo K Grimm S Grinstein Ph Gris J-F Grivaz S Groh E Gross J Grosse-Knetter G C Grossi Z J Grout C Grud A Grummer L Guan W Guan J Guenther A Guerguichon F Guescini D Guest R Gugel B Gui T Guillemin S Guindon U Gul C Gumpert J Guo W Guo Y Guo Z Guo R Gupta S Gurbuz G Gustavino B J Gutelman P Gutierrez C Gutschow C Guyot M P Guzik C Gwenlan C B Gwilliam A Haas C Haber H K Hadavand N Haddad A Hadef S Hageböck M Hagihara H Hakobyan M Haleem J Haley G Halladjian G D Hallewell K Hamacher P Hamal K Hamano A Hamilton G N Hamity K Han L Han S Han K Hanagaki M Hance D M Handl B Haney R Hankache P Hanke E Hansen J B Hansen J D Hansen M C Hansen P H Hansen K Hara A S Hard T Harenberg S Harkusha P F Harrison N M Hartmann Y Hasegawa A Hasib S Hassani S Haug R Hauser L Hauswald L B Havener M Havranek C M Hawkes R J Hawkings D Hayden C Hayes C P Hays J M Hays H S Hayward S J Haywood M P Heath V Hedberg L Heelan S Heer K K Heidegger J Heilman S Heim T Heim B Heinemann J J Heinrich L Heinrich C Heinz J Hejbal L Helary A Held S Hellesund S Hellman C Helsens R C W Henderson Y Heng S Henkelmann A M Henriques Correia G H Herbert H Herde V Herget Y Hernández Jiménez H Herr M G Herrmann T Herrmann G Herten R Hertenberger L Hervas T C Herwig G G Hesketh N P Hessey S Higashino E Higón-Rodriguez K Hildebrand E Hill J C Hill K K Hill K H Hiller S J Hillier M Hils I Hinchliffe M Hirose D Hirschbuehl B Hiti O Hladik D R Hlaluku X Hoad J Hobbs N Hod M C Hodgkinson A Hoecker M R Hoeferkamp F Hoenig D Hohn D Hohov T R Holmes M Holzbock M Homann S Honda T Honda T M Hong A Hönle B H Hooberman W H Hopkins Y Horii P Horn A J Horton L A Horyn J-Y Hostachy A Hostiuc S Hou A Hoummada J Howarth J Hoya M Hrabovsky I Hristova J Hrivnac A Hrynevich T Hryn'ova P J Hsu S-C Hsu Q Hu S Hu Y Huang Z Hubacek F Hubaut M Huebner F Huegging T B Huffman M Huhtinen R F H Hunter P Huo A M Hupe N Huseynov J Huston J Huth R Hyneman G Iacobucci G Iakovidis I Ibragimov L Iconomidou-Fayard Z Idrissi P Iengo R Ignazzi O Igonkina R Iguchi T Iizawa Y Ikegami M Ikeno D Iliadis N Ilic F Iltzsche G Introzzi M Iodice K Iordanidou V Ippolito M F Isacson N Ishijima M Ishino M Ishitsuka W Islam C Issever S Istin F Ito J M Iturbe Ponce R Iuppa A Ivina H Iwasaki J M Izen V Izzo P Jacka P Jackson R M Jacobs V Jain G Jäkel K B Jakobi K Jakobs S Jakobsen T Jakoubek D O Jamin R Jansky J Janssen M Janus P A Janus G Jarlskog N Javadov T Javůrek M Javurkova F Jeanneau L Jeanty J Jejelava A Jelinskas P Jenni J Jeong N Jeong S Jézéquel H Ji J Jia H Jiang Y Jiang Z Jiang S Jiggins F A Jimenez Morales J Jimenez Pena S Jin A Jinaru O Jinnouchi H Jivan P Johansson K A Johns C A Johnson W J Johnson K Jon-And R W L Jones S D Jones S Jones T J Jones J Jongmanns P M Jorge J Jovicevic X Ju J J Junggeburth A Juste Rozas A Kaczmarska M Kado H Kagan M Kagan T Kaji E Kajomovitz C W Kalderon A Kaluza S Kama A Kamenshchikov L Kanjir Y Kano V A Kantserov J Kanzaki B Kaplan L S Kaplan D Kar M J Kareem E Karentzos S N Karpov Z M Karpova V Kartvelishvili A N Karyukhin L Kashif R D Kass A Kastanas Y Kataoka C Kato J Katzy K Kawade K Kawagoe T Kawamoto G Kawamura E F Kay V F Kazanin R Keeler R Kehoe J S Keller E Kellermann J J Kempster J Kendrick O Kepka S Kersten B P Kerševan S Ketabchi Haghighat R A Keyes M Khader F Khalil-Zada A Khanov A G Kharlamov T Kharlamova E E Khoda A Khodinov T J Khoo E Khramov J Khubua S Kido M Kiehn C R Kilby Y K Kim N Kimura O M Kind B T King D Kirchmeier J Kirk A E Kiryunin T Kishimoto D Kisielewska V Kitali O Kivernyk E Kladiva T Klapdor-Kleingrothaus M H Klein M Klein U Klein K Kleinknecht P Klimek A Klimentov T Klingl T Klioutchnikova F F Klitzner P Kluit S Kluth E Kneringer E B F G Knoops A Knue A Kobayashi D Kobayashi T Kobayashi M Kobel M Kocian P Kodys P T Koenig T Koffas E Koffeman N M Köhler T Koi M Kolb I Koletsou T Kondo N Kondrashova K Köneke A C König T Kono R Konoplich V Konstantinides N Konstantinidis B Konya R Kopeliansky S Koperny K Korcyl K Kordas G Koren A Korn I Korolkov E V Korolkova N Korotkova O Kortner S Kortner T Kosek V V Kostyukhin A Kotwal A Koulouris A Kourkoumeli-Charalampidi C Kourkoumelis E Kourlitis V Kouskoura A B Kowalewska R Kowalewski T Z Kowalski C Kozakai W Kozanecki A S Kozhin V A Kramarenko G Kramberger D Krasnopevtsev M W Krasny A Krasznahorkay D Krauss J A Kremer J Kretzschmar P Krieger K Krizka K Kroeninger H Kroha J Kroll J Kroll J Krstic U Kruchonak H Krüger N Krumnack M C Kruse T Kubota S Kuday J T Kuechler S Kuehn A Kugel F Kuger T Kuhl V Kukhtin R Kukla Y Kulchitsky S Kuleshov Y P Kulinich M Kuna T Kunigo A Kupco T Kupfer O Kuprash H Kurashige L L Kurchaninov Y A Kurochkin A Kurova M G Kurth E S Kuwertz M Kuze J Kvita T Kwan A La Rosa J L La Rosa Navarro L La Rotonda F La Ruffa C Lacasta F Lacava J Lacey D P J Lack H Lacker D Lacour E Ladygin R Lafaye B Laforge T Lagouri S Lai S Lammers W Lampl E Lançon U Landgraf M P J Landon M C Lanfermann V S Lang J C Lange R J Langenberg A J Lankford F Lanni K Lantzsch A Lanza A Lapertosa S Laplace J F Laporte T Lari F Lasagni Manghi M Lassnig T S Lau A Laudrain M Lavorgna M Lazzaroni B Le O Le Dortz E Le Guirriec E P Le Quilleuc M LeBlanc T LeCompte F Ledroit-Guillon C A Lee G R Lee L Lee S C Lee B Lefebvre M Lefebvre F Legger C Leggett K Lehmann N Lehmann G Lehmann Miotto W A Leight A Leisos M A L Leite R Leitner D Lellouch K J C Leney T Lenz B Lenzi R Leone S Leone C Leonidopoulos G Lerner C Leroy R Les A A J Lesage C G Lester M Levchenko J Levêque D Levin L J Levinson D Lewis B Li B Li C-Q Li H Li L Li M Li Q Li Q Y Li S Li X Li Y Li Z Liang B Liberti A Liblong K Lie S Liem A Limosani C Y Lin K Lin T H Lin R A Linck J H Lindon B E Lindquist A L Lionti E Lipeles A Lipniacka M Lisovyi T M Liss A Lister A M Litke J D Little B Liu B L Liu H B Liu H Liu J B Liu J K K Liu K Liu M Liu P Liu Y Liu Y L Liu Y W Liu M Livan A Lleres J Llorente Merino S L Lloyd C Y Lo F Lo Sterzo E M Lobodzinska P Loch A Loesle T Lohse K Lohwasser M Lokajicek J D Long R E Long L Longo K A Looper J A Lopez I Lopez Paz A Lopez Solis J Lorenz N Lorenzo Martinez M Losada P J Lösel X Lou X Lou A Lounis J Love P A Love J J Lozano Bahilo H Lu M Lu N Lu Y J Lu H J Lubatti C Luci A Lucotte C Luedtke F Luehring I Luise L Luminari B Lund-Jensen M S Lutz P M Luzi D Lynn R Lysak E Lytken F Lyu V Lyubushkin T Lyubushkina H Ma L L Ma Y Ma G Maccarrone A Macchiolo C M Macdonald J Machado Miguens D Madaffari R Madar W F Mader A Madsen N Madysa J Maeda K Maekawa S Maeland T Maeno M Maerker A S Maevskiy V Magerl D J Mahon C Maidantchik T Maier A Maio O Majersky S Majewski Y Makida N Makovec B Malaescu Pa Malecki V P Maleev F Malek U Mallik D Malon C Malone S Maltezos S Malyukov J Mamuzic G Mancini I Mandić J Maneira L Manhaes de Andrade Filho J Manjarres Ramos K H Mankinen A Mann A Manousos B Mansoulie J D Mansour M Mantoani S Manzoni A Marantis G Marceca L March L Marchese G Marchiori M Marcisovsky C A Marin Tobon M Marjanovic D E Marley F Marroquim Z Marshall M U F Martensson S Marti-Garcia C B Martin T A Martin V J Martin B Martin Dit Latour M Martinez V I Martinez Outschoorn S Martin-Haugh V S Martoiu A C Martyniuk A Marzin L Masetti T Mashimo R Mashinistov J Masik A L Maslennikov L H Mason L Massa P Massarotti P Mastrandrea A Mastroberardino T Masubuchi P Mättig J Maurer B Maček S J Maxfield D A Maximov R Mazini I Maznas S M Mazza G Mc Goldrick S P Mc Kee A McCarn T G McCarthy L I McClymont E F McDonald J A Mcfayden G Mchedlidze M A McKay K D McLean S J McMahon P C McNamara C J McNicol R A McPherson J E Mdhluli Z A Meadows S Meehan T Megy S Mehlhase A Mehta T Meideck B Meirose D Melini B R Mellado Garcia J D Mellenthin M Melo F Meloni A Melzer S B Menary E D Mendes Gouveia L Meng X T Meng A Mengarelli S Menke E Meoni S Mergelmeyer S A M Merkt C Merlassino P Mermod L Merola C Meroni F S Merritt A Messina J Metcalfe A S Mete C Meyer J Meyer J-P Meyer H Meyer Zu Theenhausen F Miano R P Middleton L Mijović G Mikenberg M Mikestikova M Mikuž M Milesi A Milic D A Millar D W Miller A Milov D A Milstead A A Minaenko M Miñano Moya I A Minashvili A I Mincer B Mindur M Mineev Y Minegishi Y Ming L M Mir A Mirto K P Mistry T Mitani J Mitrevski V A Mitsou M Mittal A Miucci P S Miyagawa A Mizukami J U Mjörnmark T Mkrtchyan M Mlynarikova T Moa K Mochizuki P Mogg S Mohapatra S Molander R Moles-Valls M C Mondragon K Mönig J Monk E Monnier A Montalbano J Montejo Berlingen F Monticelli S Monzani N Morange D Moreno M Moreno Llácer P Morettini M Morgenstern S Morgenstern D Mori M Morii M Morinaga V Morisbak A K Morley G Mornacchi A P Morris J D Morris L Morvaj P Moschovakos M Mosidze H J Moss J Moss K Motohashi R Mount E Mountricha E J W Moyse S Muanza F Mueller J Mueller R S P Mueller D Muenstermann G A Mullier F J Munoz Sanchez P Murin W J Murray A Murrone M Muškinja C Mwewa A G Myagkov J Myers M Myska B P Nachman O Nackenhorst K Nagai K Nagano Y Nagasaka M Nagel E Nagy A M Nairz Y Nakahama K Nakamura T Nakamura I Nakano H Nanjo F Napolitano R F Naranjo Garcia R Narayan D I Narrias Villar I Naryshkin T Naumann G Navarro R Nayyar H A Neal P Y Nechaeva T J Neep A Negri M Negrini S Nektarijevic C Nellist M E Nelson S Nemecek P Nemethy M Nessi M S Neubauer M Neumann P R Newman T Y Ng Y S Ng H D N Nguyen T Nguyen Manh E Nibigira R B Nickerson R Nicolaidou D S Nielsen J Nielsen N Nikiforou V Nikolaenko I Nikolic-Audit K Nikolopoulos P Nilsson Y Ninomiya A Nisati N Nishu R Nisius I Nitsche T Nitta T Nobe Y Noguchi M Nomachi I Nomidis M A Nomura T Nooney M Nordberg N Norjoharuddeen T Novak O Novgorodova R Novotny L Nozka K Ntekas E Nurse F Nuti F G Oakham H Oberlack J Ocariz A Ochi I Ochoa J P Ochoa-Ricoux K O'Connor S Oda S Odaka S Oerdek A Oh S H Oh C C Ohm H Oide M L Ojeda H Okawa Y Okazaki Y Okumura T Okuyama A Olariu L F Oleiro Seabra S A Olivares Pino D Oliveira Damazio J L Oliver M J R Olsson A Olszewski J Olszowska D C O'Neil A Onofre K Onogi P U E Onyisi H Oppen M J Oreglia G E Orellana Y Oren D Orestano E C Orgill N Orlando A A O'Rourke R S Orr B Osculati V O'Shea R Ospanov G Otero Y Garzon H Otono M Ouchrif F Ould-Saada A Ouraou Q Ouyang M Owen R E Owen V E Ozcan N Ozturk J Pacalt H A Pacey K Pachal A Pacheco Pages L Pacheco Rodriguez C Padilla Aranda S Pagan Griso M Paganini G Palacino S Palazzo S 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I Pokharel G Polesello A Poley A Policicchio R Polifka A Polini C S Pollard V Polychronakos D Ponomarenko L Pontecorvo G A Popeneciu D M Portillo Quintero S Pospisil K Potamianos I N Potrap C J Potter H Potti T Poulsen J Poveda T D Powell M E Pozo Astigarraga P Pralavorio S Prell D Price M Primavera S Prince N Proklova K Prokofiev F Prokoshin S Protopopescu J Proudfoot M Przybycien A Puri P Puzo J Qian Y Qin A Quadt M Queitsch-Maitland A Qureshi P Rados F Ragusa G Rahal J A Raine S Rajagopalan A Ramirez Morales T Rashid S Raspopov M G Ratti D M Rauch F Rauscher S Rave B Ravina I Ravinovich J H Rawling M Raymond A L Read N P Readioff M Reale D M Rebuzzi A Redelbach G Redlinger R Reece R G Reed K Reeves L Rehnisch J Reichert D Reikher A Reiss C Rembser H Ren M Rescigno S Resconi E D Resseguie S Rettie E Reynolds O L Rezanova P Reznicek E Ricci R Richter S Richter E Richter-Was O Ricken M Ridel P Rieck C J Riegel O Rifki M Rijssenbeek A Rimoldi M Rimoldi L Rinaldi G Ripellino B Ristić E Ritsch I Riu J C Rivera Vergara F Rizatdinova E Rizvi C Rizzi R T Roberts S H Robertson D Robinson J E M Robinson A Robson E Rocco C Roda Y Rodina S Rodriguez Bosca A Rodriguez Perez D Rodriguez Rodriguez A M Rodríguez Vera S Roe C S Rogan O Røhne R Röhrig C P A Roland J Roloff A Romaniouk M Romano N Rompotis M Ronzani L Roos S Rosati K Rosbach N-A Rosien B J Rosser E Rossi E Rossi E Rossi L P Rossi L Rossini J H N Rosten R Rosten M Rotaru J Rothberg D Rousseau D Roy A Rozanov Y Rozen X Ruan F Rubbo F Rühr A Ruiz-Martinez Z Rurikova N A Rusakovich H L Russell J P Rutherfoord E M Rüttinger Y F Ryabov M Rybar G Rybkin S Ryu A Ryzhov G F Rzehorz P Sabatini G Sabato S Sacerdoti H F-W Sadrozinski R Sadykov F Safai Tehrani P Saha M Sahinsoy A Sahu M Saimpert M Saito T Saito H Sakamoto A Sakharov D Salamani G Salamanna J E Salazar Loyola P H Sales De Bruin D Salihagic A Salnikov J Salt D Salvatore F Salvatore A Salvucci A Salzburger J Samarati D Sammel D Sampsonidis D Sampsonidou J Sánchez A 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Zakharchuk J Zalieckas S Zambito D Zanzi D R Zaripovas S V Zeißner C Zeitnitz G Zemaityte J C Zeng Q Zeng O Zenin D Zerwas M Zgubič D F Zhang D Zhang F Zhang G Zhang G Zhang H Zhang J Zhang L Zhang L Zhang M Zhang P Zhang R Zhang R Zhang X Zhang Y Zhang Z Zhang Y Zhao Z Zhao A Zhemchugov Z Zheng D Zhong B Zhou C Zhou L Zhou M S Zhou M Zhou N Zhou Y Zhou C G Zhu H L Zhu H Zhu J Zhu Y Zhu X Zhuang K Zhukov V Zhulanov A Zibell D Zieminska N I Zimine S Zimmermann Z Zinonos M Zinser M Ziolkowski G Zobernig A Zoccoli K Zoch T G Zorbas R Zou M Zur Nedden L Zwalinski

Phys Rev Lett 2018 Nov;121(21):211801

CERN, Geneva, Switzerland.

A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T→Zt/Wb/Ht, B→Zb/Wt/Hb) is performed using 36.1  fb^{-1} of pp collision data at sqrt[s]=13  TeV with the ATLAS detector at the Large Hadron Collider. The observed data are found to be in good agreement with the standard model background prediction in all individual searches. Read More

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November 2018
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Observation of Centrality-Dependent Acoplanarity for Muon Pairs Produced via Two-Photon Scattering in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Authors:
M Aaboud G Aad B Abbott O Abdinov B Abeloos D K Abhayasinghe S H Abidi O S AbouZeid N L Abraham H Abramowicz H Abreu Y Abulaiti B S Acharya S Adachi L Adamczyk J Adelman M Adersberger A Adiguzel T Adye A A Affolder Y Afik C Agheorghiesei J A Aguilar-Saavedra F Ahmadov G Aielli S Akatsuka T P A Åkesson E Akilli A V Akimov G L Alberghi J Albert P Albicocco M J Alconada Verzini S Alderweireldt M Aleksa I N Aleksandrov C Alexa T Alexopoulos M Alhroob B Ali G Alimonti J Alison S P Alkire C Allaire B M M Allbrooke B W Allen P P Allport A Aloisio A Alonso F Alonso C Alpigiani A A Alshehri M I Alstaty B Alvarez Gonzalez D Álvarez Piqueras M G Alviggi B T Amadio Y Amaral Coutinho L Ambroz C Amelung D Amidei S P Amor Dos Santos S Amoroso C S Amrouche C Anastopoulos L S Ancu N Andari T Andeen C F Anders J K Anders K J Anderson A Andreazza V Andrei C R Anelli S Angelidakis I Angelozzi A Angerami A V Anisenkov A Annovi C Antel M T Anthony M Antonelli D J A Antrim F Anulli M Aoki J A Aparisi Pozo L Aperio Bella G Arabidze J P Araque V Araujo Ferraz R Araujo Pereira A T H Arce R E Ardell F A Arduh J-F Arguin S Argyropoulos A J Armbruster L J Armitage A Armstrong O Arnaez H Arnold M Arratia O Arslan A Artamonov G Artoni S Artz S Asai N Asbah A Ashkenazi E M Asimakopoulou L Asquith K Assamagan R Astalos R J Atkin M Atkinson N B Atlay K Augsten G Avolio R Avramidou M K Ayoub G Azuelos A E Baas M J Baca H Bachacou K Bachas M Backes P Bagnaia M Bahmani H Bahrasemani A J Bailey J T Baines M Bajic C Bakalis O K Baker P J Bakker D Bakshi Gupta E M Baldin P Balek F Balli W K Balunas J Balz E Banas A Bandyopadhyay S Banerjee A A E Bannoura L Barak W M Barbe E L Barberio D Barberis M Barbero T Barillari M-S Barisits J Barkeloo T Barklow N Barlow R Barnea S L Barnes B M Barnett R M Barnett Z Barnovska-Blenessy A Baroncelli G Barone A J Barr L Barranco Navarro F Barreiro J Barreiro Guimarães da Costa R Bartoldus A E Barton P Bartos A Basalaev A Bassalat R L Bates S J Batista S Batlamous J R Batley M Battaglia M Bauce F Bauer K T Bauer H S Bawa J B Beacham T Beau P H Beauchemin P Bechtle H C Beck H P Beck K Becker M Becker C Becot A Beddall A J Beddall V A Bednyakov M Bedognetti C P Bee T A Beermann M Begalli M Begel A Behera J K Behr A S Bell G Bella L Bellagamba A Bellerive M Bellomo P Bellos K Belotskiy N L Belyaev O Benary D Benchekroun M Bender N Benekos Y Benhammou E Benhar Noccioli J Benitez D P Benjamin M Benoit J R Bensinger S Bentvelsen L Beresford M Beretta D Berge E Bergeaas Kuutmann N Berger L J Bergsten J Beringer S Berlendis N R Bernard G Bernardi C Bernius F U Bernlochner T Berry P Berta C Bertella G Bertoli I A Bertram G J Besjes O Bessidskaia Bylund M Bessner N Besson A Bethani S Bethke A Betti A J Bevan J Beyer R M Bianchi O Biebel D Biedermann R Bielski K Bierwagen N V Biesuz M Biglietti T R V Billoud M Bindi A Bingul C Bini S Biondi M Birman T Bisanz J P Biswal C Bittrich D M Bjergaard J E Black K M Black T Blazek I Bloch C Blocker A Blue U Blumenschein Dr Blunier G J Bobbink V S Bobrovnikov S S Bocchetta A Bocci D Boerner D Bogavac A G Bogdanchikov C Bohm V Boisvert P Bokan T Bold A S Boldyrev A E Bolz M Bomben M Bona J S Bonilla M Boonekamp A Borisov G Borissov J Bortfeldt D Bortoletto V Bortolotto D Boscherini M Bosman J D Bossio Sola K Bouaouda J Boudreau E V Bouhova-Thacker D Boumediene C Bourdarios S K Boutle A Boveia J Boyd D Boye I R Boyko A J Bozson J Bracinik N Brahimi A Brandt G Brandt O Brandt F Braren U Bratzler B Brau J E Brau W D Breaden Madden K Brendlinger A J Brennan L Brenner R Brenner S Bressler B Brickwedde D L Briglin D Britton D Britzger I Brock R Brock G Brooijmans T Brooks W K Brooks E Brost J H Broughton P A Bruckman de Renstrom D Bruncko A Bruni G Bruni L S Bruni S Bruno B H Brunt M Bruschi N Bruscino P Bryant L Bryngemark T Buanes Q Buat P Buchholz A G Buckley I A Budagov F Buehrer M K Bugge O Bulekov D Bullock T J Burch S Burdin C D Burgard A M Burger B Burghgrave K Burka S Burke I Burmeister J T P Burr D Büscher V Büscher E Buschmann P Bussey J M Butler C M Buttar J M Butterworth P Butti W Buttinger A Buzatu A R Buzykaev G Cabras S Cabrera Urbán D Caforio H Cai V M M Cairo O Cakir N Calace P Calafiura A Calandri G Calderini P Calfayan G Callea L P Caloba S Calvente Lopez D Calvet S Calvet T P Calvet M Calvetti R Camacho Toro S Camarda P Camarri D Cameron R Caminal Armadans C Camincher S Campana M Campanelli A Camplani A Campoverde V Canale M Cano Bret J Cantero T Cao Y Cao M D M Capeans Garrido I Caprini M Caprini M Capua R M Carbone R Cardarelli F C Cardillo I Carli T Carli G Carlino B T Carlson L Carminati R M D Carney S Caron E Carquin S Carrá G D Carrillo-Montoya D Casadei M P Casado A F Casha D W Casper R Castelijn F L Castillo V Castillo Gimenez N F Castro A Catinaccio J R Catmore A Cattai J Caudron V Cavaliere E Cavallaro D Cavalli M Cavalli-Sforza V Cavasinni E Celebi F Ceradini L Cerda Alberich A S Cerqueira A Cerri L Cerrito F Cerutti A Cervelli S A Cetin A Chafaq D Chakraborty S K Chan W S Chan Y L Chan J D Chapman B Chargeishvili D G Charlton C C Chau C A Chavez Barajas S Che A Chegwidden S Chekanov S V Chekulaev G A Chelkov M A Chelstowska C Chen C H Chen H Chen J Chen J Chen S Chen S J Chen X Chen Y Chen Y-H Chen H C Cheng H J Cheng A Cheplakov E Cheremushkina R Cherkaoui El Moursli E Cheu K Cheung L Chevalier V Chiarella G Chiarelli G Chiodini A S Chisholm A Chitan I Chiu Y H Chiu M V Chizhov K Choi A R Chomont S Chouridou Y S Chow V Christodoulou M C Chu J Chudoba A J Chuinard J J Chwastowski L Chytka D Cinca V Cindro I A Cioară A Ciocio F Cirotto Z H Citron M Citterio A Clark M R Clark P J Clark C Clement Y Coadou M Cobal A Coccaro J Cochran A E C Coimbra L Colasurdo B Cole A P Colijn J Collot P Conde Muiño E Coniavitis S H Connell I A Connelly S Constantinescu F Conventi A M Cooper-Sarkar F Cormier K J R Cormier M Corradi E E Corrigan F Corriveau A Cortes-Gonzalez M J Costa D Costanzo G Cottin G Cowan B E Cox J Crane K Cranmer S J Crawley R A Creager G Cree S Crépé-Renaudin F Crescioli M Cristinziani V Croft G Crosetti A Cueto T Cuhadar Donszelmann A R Cukierman J Cúth S Czekierda P Czodrowski M J Da Cunha Sargedas De Sousa C Da Via W Dabrowski T Dado S Dahbi T Dai F Dallaire C Dallapiccola M Dam G D'amen J Damp J R Dandoy M F Daneri N P Dang N D Dann M Danninger V Dao G Darbo S Darmora O Dartsi A Dattagupta T Daubney S D'Auria W Davey C David T Davidek D R Davis E Dawe I Dawson K De R De Asmundis A De Benedetti M De Beurs S De Castro S De Cecco N De Groot P de Jong H De la Torre F De Lorenzi A De Maria D De Pedis A De Salvo U De Sanctis A De Santo K De Vasconcelos Corga J B De Vivie De Regie C Debenedetti D V Dedovich N Dehghanian M Del Gaudio J Del Peso Y Delabat Diaz D Delgove F Deliot C M Delitzsch M Della Pietra D Della Volpe A Dell'Acqua L Dell'Asta M Delmastro C Delporte P A Delsart D A DeMarco S Demers M Demichev S P Denisov D Denysiuk L D'Eramo D Derendarz J E Derkaoui F Derue P Dervan K Desch C Deterre K Dette M R Devesa P O Deviveiros A Dewhurst S Dhaliwal F A Di Bello A Di Ciaccio L Di Ciaccio W K Di Clemente C Di Donato A Di Girolamo B Di Micco R Di Nardo K F Di Petrillo R Di Sipio D Di Valentino C Diaconu M Diamond F A Dias T Dias Do Vale M A Diaz J Dickinson E B Diehl J Dietrich S Díez Cornell A Dimitrievska J Dingfelder F Dittus F Djama T Djobava J I Djuvsland M A B Do Vale M Dobre D Dodsworth C Doglioni J Dolejsi Z Dolezal M Donadelli J Donini A D'onofrio M D'Onofrio J Dopke A Doria M T Dova A T Doyle E Drechsler E Dreyer T Dreyer Y Du J Duarte-Campderros F Dubinin M Dubovsky A Dubreuil E Duchovni G Duckeck A Ducourthial O A Ducu D Duda A Dudarev A C Dudder E M Duffield L Duflot M Dührssen C Dülsen M Dumancic A E Dumitriu A K Duncan M Dunford A Duperrin H Duran Yildiz M Düren A Durglishvili D Duschinger B Dutta D Duvnjak M Dyndal S Dysch B S Dziedzic C Eckardt K M Ecker R C Edgar T Eifert G Eigen K Einsweiler T Ekelof M El Kacimi R El Kosseifi V Ellajosyula M Ellert F Ellinghaus A A Elliot N Ellis J Elmsheuser M Elsing D Emeliyanov Y Enari J S Ennis M B Epland J Erdmann A Ereditato S Errede M Escalier C Escobar O Estrada Pastor A I Etienvre E Etzion H Evans A Ezhilov M Ezzi F Fabbri L Fabbri V Fabiani G Facini R M Faisca Rodrigues Pereira R M Fakhrutdinov S Falciano P J Falke S Falke J Faltova Y Fang M Fanti A Farbin A Farilla E M Farina T Farooque S Farrell S M Farrington P Farthouat F Fassi P Fassnacht D Fassouliotis M Faucci Giannelli A Favareto W J Fawcett L Fayard O L Fedin W Fedorko M Feickert S Feigl L Feligioni C Feng E J Feng M Feng M J Fenton A B Fenyuk L Feremenga J Ferrando A Ferrari P Ferrari R Ferrari D E Ferreira de Lima A Ferrer D Ferrere C Ferretti F Fiedler A Filipčič F Filthaut K D Finelli M C N Fiolhais L Fiorini C Fischer W C Fisher N Flaschel I Fleck P Fleischmann R R M Fletcher T Flick B M Flierl L M Flores L R Flores Castillo F M Follega N Fomin G T Forcolin A Formica F A Förster A C Forti A G Foster D Fournier H Fox S Fracchia P Francavilla M Franchini S Franchino D Francis L Franconi M Franklin M Frate M Fraternali D Freeborn S M Fressard-Batraneanu B Freund W S Freund D Froidevaux J A Frost C Fukunaga E Fullana Torregrosa T Fusayasu J Fuster O Gabizon A Gabrielli A Gabrielli G P Gach S Gadatsch P Gadow G Gagliardi L G Gagnon C Galea B Galhardo E J Gallas B J Gallop P Gallus G Galster R Gamboa Goni K K Gan S Ganguly J Gao Y Gao Y S Gao C García J E García Navarro J A García Pascual M Garcia-Sciveres R W Gardner N Garelli V Garonne K Gasnikova A Gaudiello G Gaudio I L Gavrilenko A Gavrilyuk C Gay G Gaycken E N Gazis C N P Gee J Geisen M Geisen M P Geisler K Gellerstedt C Gemme M H Genest C Geng S Gentile S George D Gerbaudo G Gessner S Ghasemi M Ghasemi Bostanabad M Ghneimat B Giacobbe S Giagu N Giangiacomi P Giannetti A Giannini S M Gibson M Gignac D Gillberg G Gilles D M Gingrich M P Giordani F M Giorgi P F Giraud P Giromini G Giugliarelli D Giugni F Giuli M Giulini S Gkaitatzis I Gkialas E L 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O Zenin D Zerwas M Zgubič D F Zhang D Zhang F Zhang G Zhang H Zhang J Zhang L Zhang L Zhang M Zhang P Zhang R Zhang R Zhang X Zhang Y Zhang Z Zhang P Zhao X Zhao Y Zhao Z Zhao A Zhemchugov B Zhou C Zhou L Zhou M S Zhou M Zhou N Zhou Y Zhou C G Zhu H L Zhu H Zhu J Zhu Y Zhu X Zhuang K Zhukov V Zhulanov A Zibell D Zieminska N I Zimine S Zimmermann Z Zinonos M Zinser M Ziolkowski G Zobernig A Zoccoli K Zoch T G Zorbas R Zou M Zur Nedden L Zwalinski

Phys Rev Lett 2018 Nov;121(21):212301

CERN, Geneva, Switzerland.

This Letter presents a measurement of γγ→μ^{+}μ^{-} production in Pb+Pb collisions recorded by the ATLAS detector at the Large Hadron Collider at sqrt[s_{NN}]=5.02  TeV with an integrated luminosity of 0.49  nb^{-1}. Read More

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November 2018

The unique mechanism of functional mitral regurgitation in acute myocardial infarction: a prospective dynamic 4D quantitative echocardiographic study.

Eur Heart J Cardiovasc Imaging 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Aims: Mechanisms of chronic ischaemic mitral regurgitation (IMR) are well-characterized by apically tethered leaflet caused by papillary muscles (PMs) displacement and adynamic mitral apparatus. We investigated the unique geometry and dynamics of the mitral apparatus in first acute myocardial infarction (MI) by using quantified 3D echocardiography.

Methods And Results: We prospectively performed 3D echocardiography 2. Read More

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December 2018
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Comparison of the Effects of Epidural Analgesia and Patient-controlled Intravenous Analgesia on Postoperative Pain Relief and Recovery After Laparoscopic Gastrectomy for Gastric Cancer.

Surg Laparosc Endosc Percutan Tech 2018 Dec 3. Epub 2018 Dec 3.

Departments of Gastroenterological Surgery.

Purpose: Epidural analgesia (EDA) is an imperative modality for postoperative pain relief after major open abdominal surgery. However, whether EDA has benefits in laparoscopic surgery has not been clear. In this study, the effects of EDA and patient-controlled intravenous analgesia (PCIA) after laparoscopic distal gastrectomy (LDG) were compared. Read More

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December 2018

Clinical features of Helicobacter pylori antibody-positive junior high school students in Nagano Prefecture, Japan.

Helicobacter 2018 Dec 4:e12559. Epub 2018 Dec 4.

Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan.

Background: Previously, we conducted an epidemiological study screening for Helicobacter pylori antibody positivity among Japanese junior high school students. In this study, we updated the epidemiological data and assessed the clinical features of H pylori antibody-positive junior high school students.

Materials And Methods: We assessed H pylori antibody-positive subjects who were identified between 2012 and 2015 at four junior high schools in Nagano Prefecture, Japan. Read More

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December 2018

PECAM/eGFP transgenic mice for monitoring of angiogenesis in health and disease.

Sci Rep 2018 Dec 4;8(1):17582. Epub 2018 Dec 4.

Institute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.

For the monitoring of vascular growth as well as adaptive or therapeutic (re)vascularization endothelial-specific reporter mouse models are valuable tools. However, currently available mouse models have limitations, because not all endothelial cells express the reporter in all developmental stages. We have generated PECAM/eGFP embryonic stem (ES) cell and mouse lines where the reporter gene labels PECAM endothelial cells and vessels with high specificity. Read More

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December 2018
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Combination of Roll Grinding and High-Pressure Homogenization Can Prepare Stable Bicelles for Drug Delivery.

Nanomaterials (Basel) 2018 Dec 3;8(12). Epub 2018 Dec 3.

Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

To improve the solubility of the drug nifedipine (NI), NI-encapsulated lipid-based nanoparticles (NI-LNs) have been prepared from neutral hydrogenated soybean phosphatidylcholine and negatively charged dipalmitoylphosphatidylglycerol at a molar ratio of 5/1 using by roll grinding and high-pressure homogenization. The NI-LNs exhibited high entrapment efficiency, long-term stability, and enhanced NI bioavailability. To better understand their structures, cryo transmission electron microscopy and atomic force microscopy were performed in the present study. Read More

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December 2018

Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces.

Pharmaceutics 2018 Dec 3;10(4). Epub 2018 Dec 3.

Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Klingelbergstrasse 50, CH4056 Basel, Switzerland.

Manufacturing parameters may have a strong impact on the dissolution and disintegration of solid dosage forms. In line with process analytical technology (PAT) and quality by design approaches, computer-based technologies can be used to design, control, and improve the quality of pharmaceutical compacts and their performance. In view of shortcomings of computationally intensive finite-element or discrete-element methods, we propose a modeling and simulation approach based on numerical solutions of the Noyes-Whitney equation in combination with a cellular automata-supported disintegration model. Read More

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December 2018

Combined aortic arch resection for lung cancer using total rerouting of supra-arch vessels.

Ann Thorac Surg 2018 Dec 1. Epub 2018 Dec 1.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, Japan.

Surgery for aortic arch involvement in lung cancer cases is challenging, and generally requires extracorporeal circulation with circulatory arrest or a cerebral protection technique. To reduce morbidity, we developed a novel surgical technique for total aortic arch replacement for lung cancer with aortic arch involvement that features total rerouting of supra-arch vessels under a beating heart condition. A 56-year-old male was diagnosed with lung cancer and aortic arch invasion was suspected. Read More

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December 2018
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An Easy and Safe Method of Liver Retraction Using a Silicone Disc and Needle Forceps for Laparoscopic Gastrectomy.

J Laparoendosc Adv Surg Tech A 2018 Dec 4. Epub 2018 Dec 4.

Department of Gastroenterological, General, Breast and Thyroid Surgery, Faculty of Medicine, Yamagata University , Yamagata City, Japan .

Background: For safe laparoscopic gastrectomy, it is essential to secure a good visual field by employing liver retraction. We have developed a safe and easy method for liver retraction using a silicone disc, and evaluated its feasibility.

Methods: We analyzed retrospectively 36 patients with gastric cancer, who underwent laparoscopic distal gastrectomy employing liver retraction by a silicone disc and needle forceps (Silicone group) or by the Penrose drain method (Penrose group) between January 2013 and July 2016. Read More

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December 2018
4 Reads

Egg white hydrolysate improves fatigue due to short-term swimming load test in mice.

Food Sci Nutr 2018 Nov 10;6(8):2314-2320. Epub 2018 Oct 10.

R&D Division Kewpie Corporation Tokyo Japan.

We studied the effect of egg white hydrolysate (EWH) on swimming endurance in mice. 7-week-old male ddY mice (28-30 g) were divided into three groups and fed an AIN-93G diet supplemented with casein ( = 8), EWH ( = 7), or egg white protein (EWP,  = 8) for 14 days. From day 11, the mice underwent a swimming test daily with a weight load equivalent to 10% of their body weight, and the lengths of time they swam were recorded. Read More

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November 2018

Composition and biochemical properties of l-carnitine fortified Makgeolli brewed by using fermented buckwheat.

Food Sci Nutr 2018 Nov 11;6(8):2293-2300. Epub 2018 Oct 11.

Graduate School of International Agricultural Technology Seoul National University Pyeongchang-gun Gangwon-do Korea.

Makgeolli is a traditional Korean alcoholic rice beverage. It is brewed of ingredients containing starch, Nuruk, and water. In order to improve the quality and functionality of Makgeolli, the fermented buckwheat containing 18. Read More

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November 2018

Different profiles of naturally produced and anthropogenic organohalogens in the livers of cetaceans from the Sea of Japan and the North Pacific Ocean.

Mar Pollut Bull 2018 Nov 15;136:230-242. Epub 2018 Sep 15.

Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan. Electronic address:

Levels and profiles of naturally produced halogenated bipyrroles (BrCl-DBP and Cl-MBP), methoxylated tetrabromodiphenyl ethers (6-MeO-BDE47), anthropogenic perfluoroalkyl substances (PFASs) and legacy persistent organic pollutants (POPs) were investigated in the livers of 14 cetaceans from the Sea of Japan and the North Pacific Ocean. The concentrations of BrCl-DBP (4 to 4900 ng/g-wet), Cl-MBP (16 to 3960 ng/g-wet) and 6-MeO-BDE47 (7 to 190 ng/g-wet) were higher in the order of killer whales > toothed whales > baleen whales. Profiles of PFASs were dominated by perfluoroundecanoic and perfluorotridecanoic acids (10 to 540 ng/g-wet), sum of which accounted for 70% of total measured PFASs. Read More

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November 2018
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