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    Add-on iguratimod as a therapeutic strategy to achieve remission in patients with rheumatoid arthritis inadequately responding to biological DMARDs: A retrospective study.
    Mod Rheumatol 2017 Jun 23:1-8. Epub 2017 Jun 23.
    a Department of Internal Medicine IV , Osaka Medical College , Osaka , Japan.
    Objectives: In this study, iguratimod (IGU) was added to rheumatoid arthritis (RA) patients inadequately responding to 24-week or longer treatment with biological disease-modifying antirheumatic drug (bDMARDs), its effectiveness was assessed, and factors contributing to remission were evaluated.

    Methods: RA patients who fulfilled the following criteria were included: (i) ≥ 24-week of bDMARDs; (ii) 2.6 < disease activity score (DAS) 28-erythrocyte sedimentation rate (ESR) < 5. Read More

    Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy.
    Circ J 2017 Jun 20. Epub 2017 Jun 20.
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
    Background: TheSCN5Agene encodes the α subunit of the cardiac voltage-gated sodium channel, NaV1.5. The missense mutation, D1275N, has been associated with a range of unusual phenotypes associated with reduced NaV1. Read More

    Angiolymphoid hyperplasia with eosinophilia of the nail unit.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Weill Cornell Medical College, Department of Dermatology, New York, New York.
    Angiolymphoid hyperplasia with eosinophilia (ALHE) is a distinctive lymphocyte rich vasoformative proliferation comprising epithelioid-appearing endothelial cells with partially canalized capillary vessels in a lymphohistiocytic and eosinophil rich environment. ALHE presents clinically as single or multiple pink-brown dome-shaped papules or nodules, most commonly on the ear and peri-auricular area, followed by the face, and scalp. ALHE involving the subungual unit is rare with only 5 previously reported cases and all involved the underlying bone. Read More

    Short Telomeres, but Not Telomere Attrition Rates, Are Associated With Carotid Atherosclerosis.
    Hypertension 2017 Jun 19. Epub 2017 Jun 19.
    From the INSERM UMRS 1116 (S.T., C.L., P.R., A.B.), Department of Geriatric Medicine, CHRU de Nancy (C.L., A.B.), and Inserm, Centre d'Investigations Cliniques-Plurithématique 14-33, CHRU Nancy (P.R.), Université de Lorraine, Nancy, France; Cardiology Center, Ghardaia, Algeria (M.T.); and Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.).
    Short telomeres are associated with atherosclerosis. However, the temporal relationship between atherosclerosis and telomere length is unclear. The objective of this work was to examine the temporal formation and progression of carotid atherosclerotic plaques in relation to telomere dynamics. Read More

    Association between Overall Lifestyle Changes and the Incidence of Proteinuria: A Population-based, Cohort Study.
    Intern Med 2017 15;56(12):1475-1484. Epub 2017 Jun 15.
    Steering Committee for "Design of the comprehensive health care system for chronic kidney disease based on the individual risk assessment by Specific Health Checkups", Japan.
    Objective This study aimed to examine the association between the changes in an overall healthy lifestyle, as quantified by the number of unhealthy lifestyle factors and obesity status, and the incidence of proteinuria in the general Japanese population. Methods A retrospective cohort study was conducted among 99,404 (men, 36.9%) participants aged from 40-74 years of age who underwent two health check-ups with a 1-year interval in Japan between 2008 and 2009. Read More

    Effects of home-based exercise on pre-dialysis chronic kidney disease patients: a randomized pilot and feasibility trial.
    BMC Nephrol 2017 Jun 17;18(1):198. Epub 2017 Jun 17.
    Japan Community Health care Organization Tokyo Takanawa Hospital, Tokyo, Japan.
    Background: Only a few research is available on the effects of home-based exercise training on pre-dialysis chronic kidney disease (CKD) patients. Therefore, we aimed to elucidate the effect of home-based exercise therapy on kidney function and arm and leg muscle strength in pre-dialysis CKD patients.

    Methods: Thirty-six male stage 3-4 pre-dialysis CKD patients (age, 68. Read More

    Prevalence of chronic obstructive pulmonary disease in independent community-dwelling older adults: The Fujiwara-kyo study.
    Geriatr Gerontol Int 2017 Jun 16. Epub 2017 Jun 16.
    Second Department of Internal Medicine, Nara Medical University, Nara, Japan.
    Aim: As the Japanese population ages, the number of older patients with chronic obstructive pulmonary disease (COPD) is expected to increase, but the prevalence of COPD in patients aged ≥80 years remains unclear. The purpose of the present study was to determine the prevalence of COPD in independent community-dwelling older adults aged ≥80 years.

    Methods: We investigated the prevalence of COPD in 2862 independent community-dwelling older adults (1504 men, 1358 women, mean age 77. Read More

    Successful revascularization improves long-term clinical outcome in patients with chronic coronary total occlusion.
    Int J Cardiol Heart Vasc 2017 Mar 1;14:28-32. Epub 2016 Dec 1.
    Department of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Aichi, Japan.
    Background: Following the development of breakthrough techniques for percutaneous coronary intervention (PCI) in the treatment of chronic total occlusions (CTO), the initial success rate of PCI in CTO lesions (CTO-PCI) has improved; however, there are few reports regarding the effects of successful CTO revascularization on long-term mortality in Japan. The aim of this study was to compare the long-term clinical outcomes of patients with successful versus failed CTO recanalization and to identify related factors.

    Methods And Results: From all PCI procedures performed in our hospital between 2006 and 2013, CTO-PCIs were extracted and classified into two groups: PCI success (n = 656 patients) and PCI failure (n = 82 patients). Read More

    Immunoglobulin G4-related disease preceded by lung involvement: A case report.
    Medicine (Baltimore) 2017 Jun;96(24):e7086
    Department of Hematology/Respiratory Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan.
    Rationale: Immunoglobulin G4-related disease (IgG4-RD) is a systemic condition involving various organs and vessels including the pancreas, bile duct, salivary glands, periorbital tissues, kidneys, lungs, lymph nodes, meninges, and aorta. Recently, some cases of IgG4-RD have been reported, in which only pulmonary lesions were present. It is not known whether IgG4-RD can be diagnosed on the basis of pulmonary lesions only, because increases in serum IgG4 levels and infiltration of IgG4-positive plasma cells into the lung tissue also occur in other inflammatory conditions. Read More

    Comparison Between Laparoscopy and Laparotomy in Systematic Para-Aortic Lymphadenectomy for Patients with Endometrial Cancer: A Retrospective Multicenter Study.
    J Gynecol Surg 2017 Jun;33(3):105-110
    Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Osaka, Japan.
    Objective: Laparoscopic surgery has been developed worldwide due to its minimal invasion as well as noninferiority, compared with laparotomy. However, whether or not laparoscopic systematic para-aortic lymphadenectomy for endometrial cancer is feasible and has advantages of various clinical factors, such as a short hospital stay, less blood loss, and faster recovery, compared with open surgery has not yet been clarified. The aim of this study was to compare a laparoscopic procedure with laparotomy for para-aortic lymphadenectomy for patients with endometrial cancer. Read More

    A proposal of clinical ECG index "vagal score" for determining the mechanism of paroxysmal atrioventricular block.
    J Arrhythm 2017 Jun 9;33(3):208-213. Epub 2016 Nov 9.
    Department of Cardiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan.
    Background: Paroxysmal atrioventricular block (P-AVB) is a well-known cause of syncope; however, its underlying mechanism is difficult to determine. This study aimed to evaluate a new ECG index, the "vagal score (VS)," to determine the mechanism of P-AVB.

    Methods: We evaluated the VS in 20 patients with P-AVB (13 men, 7 women; aged 25-78 years [mean, 59. Read More

    The Significance of Pretreatment Thrombocytosis and Its Association With Neutrophilia in Patients With Surgically Treated Endometrial Cancer.
    Int J Gynecol Cancer 2017 Jun 10. Epub 2017 Jun 10.
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
    Objective: The aim of this study was to investigate the prognostic significance of a pretreatment thrombocytosis and its association with neutrophilia in patients with surgically treated endometrial cancer.

    Methods: The baseline characteristics and outcome data of 508 patients with surgically treated endometrial cancer between January 2000 and December 2010 were collected and retrospectively reviewed. The patients were separated into 4 groups according to their platelet counts and the neutrophil counts, and the progression-free and overall survival rates of the 4 groups were compared. Read More

    Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer's disease.
    J Nat Med 2017 Jun 9. Epub 2017 Jun 9.
    Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.
    A series of prenylated resveratrol derivatives were designed, semisynthesized and biologically evaluated for inhibition of β-secretase (BACE1) and amyloid-β (Aβ) aggregation as well as free radical scavenging and neuroprotective and neuritogenic activities, as potential novel multifunctional agents against Alzheimer's disease (AD). The results showed that compound 4b exhibited good anti-Aβ aggregation (IC50 = 4.78 µM) and antioxidant activity (IC50 = 41. Read More

    Altered expression of microRNAs in patients with pouchitis after restorative proctocolectomy.
    Surg Today 2017 Jun 9. Epub 2017 Jun 9.
    Department of Surgery, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
    Background And Purpose: Pouchitis is the most common long-term complication of restorative proctocolectomy with ileal pouch-anal anastomosis. We investigated alterations in the expression of microRNAs, noncoding RNAs that act as potent negative regulators of gene expression, in pouchitis.

    Methods: The subjects of this study were 16 patients with diagnosed pouchitis and 48 patients without pouchitis after restorative proctocolectomy, performed for ulcerative colitis. Read More

    Ultrasound Imaging of Mouse Fetal Intracranial Hemorrhage Due to Ischemia/Reperfusion.
    Front Physiol 2017 24;8:340. Epub 2017 May 24.
    Graduate School of Medicine, Tohoku UniversitySendai, Japan.
    Despite vast improvement in perinatal care during the 30 years, the incidence rate of neonatal encephalopathy remains unchanged without any further Progress towards preventive strategies for the clinical impasse. Antenatal brain injury including fetal intracranial hemorrhage caused by ischemia/reperfusion is known as one of the primary triggers of neonatal injury. However, the mechanisms of antenatal brain injury are poorly understood unless better predictive models of the disease are developed. Read More

    [Hybrid Coronary Revascularization of Minimally Invasive Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention in a Patient with Left Main Coronary Stenosis].
    Kyobu Geka 2017 Jun;70(6):414-417
    Department of Cardiovascular Surgery, Saku Central Hospital Advanced Care Center, Saku, Japan.
    We report a successful case of hybrid coronary revascularization of minimally invasive coronary artery bypass grafting( MICS-CABG) and percutaneous coronary intervention(PCI). The patient was a 78-year-old man with angina pectoris due to left main trunk (LMT) lesion, and had a history of repeated PCI to the left anterior descending artery (LAD) and the left circumflex artery (LCX) for angina pectoris. He presented with a chest pain on effort in June, 2015. Read More

    Possible involvement of CCR7(-) PD-1(+) follicular helper T cell subset in the pathogenesis of autoimmune hepatitis.
    J Gastroenterol Hepatol 2017 Jun 7. Epub 2017 Jun 7.
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
    Background And Aim: Recent studies have demonstrated that B cells and follicular helper T (Tfh) cells, which are central regulators of humoral immune response, contribute to the development and progression of autoimmune diseases. Because Tfh cells can be divided into several subsets with distinct functional properties, this study aimed to examine the roles of different subsets of circulating Tfh cells in the immune pathogenesis of autoimmune hepatitis (AIH).

    Methods: Thirty-five patients with AIH, 28 patients with primary biliary cholangitis, 24 patients with chronic hepatitis B (CHB), and 44 health controls (HC) were enrolled. Read More

    Combination therapy with gemcitabine and nab-paclitaxel for locally advanced unresectable pancreatic cancer.
    Mol Clin Oncol 2017 Jun 8;6(6):963-967. Epub 2017 May 8.
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.
    The aim of the present study was to investigate the early treatment outcomes of combined gemcitabine and nab-paclitaxel treatment for locally advanced unresectable pancreatic cancer (LURPC). The subjects comprised 7 patients with LURPC receiving the abovementioned combination therapy at the Hirosaki University Hospital (Hirosaki, Japan) between January and September, 2015. The clinicopathological factors, adverse events and response to treatment were investigated. Read More

    Plasma T790M and HGF as potential predictive markers for EGFR-TKI re-challenge.
    Oncol Lett 2017 Jun 24;13(6):4939-4946. Epub 2017 Apr 24.
    Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
    Re-challenge with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) has been suggested to potentially improve survival in certain populations of patients with advanced lung cancer, but predictive markers for the success of EGFR-TKI re-challenge have not been identified. The present study analyzed 16 re-challenges with EGFR-TKI undertaken in 12 patients with lung adenocarcinoma by investigating T790M and hepatocyte growth factor (HGF) in plasma coupled with clinical characteristics. EGFR mutations in plasma DNA were detected using the wild inhibiting PCR and quenched probe system for exon 19 deletions, and T790M and L858R were detected using the mutation-biased PCR and quenched probe system. Read More

    Comparison of Different Disease-Specific Health-Related Quality of Life Measurements in Patients with Long-Term Noninvasive Ventilation.
    Can Respir J 2017 15;2017:8295079. Epub 2017 May 15.
    Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Background: Two disease-specific questionnaires have been developed to assess health-related quality of life (HRQL) in patients with chronic respiratory failure: the Severe Respiratory Insufficiency (SRI) Questionnaire and the Maugeri Respiratory Failure (MRF) Questionnaire. We aimed to compare the characteristics of the SRI, MRF-26, and St. George's Respiratory Questionnaire (SGRQ) for use in patients with home noninvasive ventilation (NIV). Read More

    Involvement of Charcot-Marie-Tooth disease gene mitofusin 2 expression in paclitaxel-induced mechanical allodynia in rats.
    Neurosci Lett 2017 Jun 3;653:337-340. Epub 2017 Jun 3.
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Jonan-ku, Fukuoka, 814-0180, Japan.
    Paclitaxel induces peripheral neuropathy, which is dose-limiting and results in loss of quality of life. Therefore, the prevention and treatment of paclitaxel-induced peripheral neuropathy are major concerns in clinical cancer therapy. However, the detailed mechanisms have not been fully elucidated. Read More

    Management of infection during chemotherapy for acute leukemia in Japan: a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group.
    Support Care Cancer 2017 Jun 6. Epub 2017 Jun 6.
    National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
    Purpose: We performed a nationwide questionnaire-based survey to evaluate the current clinical practices of infectious complications during chemotherapy for acute leukemia in Japan.

    Methods: We e-mailed a questionnaire to member institutions of the Japan Adult Leukemia Study Group in September, 2013. The questionnaire consisted of 50 multiple-choice questions covering therapeutic environment, antimicrobial prophylaxis, screening test during neutropenia, empirical therapy for febrile neutropenia, and the use of granulocyte-colony stimulating factor. Read More

    Imported malaria in pregnant women experienced in Japan.
    J Infect Chemother 2017 Jun 2. Epub 2017 Jun 2.
    Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
    Introduction: With ever-growing global exchanges, the number of travelers, including pregnant women, to the tropics is increasing, which poses a risk of contracting malaria. Although there are several reports on imported malaria in pregnancy from Western countries, those focusing on cases experienced in Japan are very limited.

    Methods: We searched for cases of malaria in pregnancy in the treatment records submitted to the Research Group on Chemotherapy of Tropical Diseases, Japan, during the period 1993-2016. Read More

    Immunosuppressive medication is not associated with surgical site infection after surgery for intractable ulcerative colitis in children.
    Intractable Rare Dis Res 2017 May;6(2):106-113
    Members of the Japanese Society for Pediatric Inflammatory Bowel Disease Working Group.
    Pediatric ulcerative colitis (UC) sometimes progresses to an intractable condition for medical therapy. The surgical management of UC is challenging because of difficult procedures and frequent infectious complications. The aim of this study was to survey surgical procedures and infectious complications in pediatric patients with UC in Japan and to assess the relationship between preoperatively administered immunosuppressive drugs and postoperative surgical site infection (SSI). Read More

    Knee joint preservation surgery in osteosarcoma using tumour-bearing bone treated with liquid nitrogen.
    Int Orthop 2017 Jun 1. Epub 2017 Jun 1.
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
    Purpose: To preserve the joint structure in order to maintain good limb function in patients with osteosarcoma, we perform epiphyseal or metaphyseal osteotomy and reconstruction using frozen autografts that contain a tumour treated with liquid nitrogen. There are two methods of using liquid nitrogen-treated autografts: the free-freezing method and the pedicle-freezing method. The purpose of this study was to evaluate the results of intentional joint-preserving reconstruction using the free-freezing method and the pedicle-freezing method in patients with osteosarcoma. Read More

    Febuxostat for the Prevention of Recurrent 2,8-dihydroxyadenine Nephropathy due to Adenine Phosphoribosyltransferase Deficiency Following Kidney Transplantation.
    Intern Med 2017 1;56(11):1387-1391. Epub 2017 Jun 1.
    Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Japan.
    Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder that results in irreversible renal damage due to 2,8-dihydroxyadenine (DHA) nephropathy. A 28-year-old man underwent living-related kidney transplantation for chronic kidney disease of unknown etiology. Numerous spherical brownish crystals observed in his urinary sediment on postoperative day 3 and were observed within the tubular lumen of renal allograft biopsy specimens on postoperative day 7. Read More

    Association between lower air pressure and the onset of ischemic colitis: a case-control study.
    Eur J Gastroenterol Hepatol 2017 May 30. Epub 2017 May 30.
    aDepartment of Gastroenterology, Suwa Red Cross Hospital, Suwa bDepartment of Gastroenterology, Nagano Red Cross Hospital, Nagano cDepartment of Internal Medicine, Division of Gastroenterology dDepartment of Metabolic Regulation, Shinshu University Graduate School of Medicine eCenter for Clinical Research, Shinshu University Hospital, Matsumoto fFaculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo gDigestive Disease Center, Showa Inan General Hospital, Komagane, Japan.
    Objective: Ischemic colitis (IC) often affects the elderly. Proarteriosclerotic factors, such as hypertension and smoking, and cardiovascular disease are considered major contributors to IC. Although a possible link between certain cerebrocardiovascular disorders and meteorological phenomena has been reported, the relationship between IC onset and weather changes remains uninvestigated. Read More

    Sputum Basophils and Asthma Diagnosis: Dawn of a New Era?
    Allergy 2017 May 31. Epub 2017 May 31.
    Respiratory Medicine, Bern University Hospital, University of Bern, Switzerland.
    More than 40 years ago, Kimura et al. discovered that basophils are enriched in sputum samples of asthma patients (1). Since then, various scientific approaches have attempted to elucidate the role of basophils in the pathophysiology of asthma. Read More

    The metabolic profile of a rat model of chronic kidney disease.
    PeerJ 2017 23;5:e3352. Epub 2017 May 23.
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Background: The kidney is always subjected to high metabolic demand. The aim of this study was to characterize metabolic profiles of a rat model of chronic kidney disease (CKD) with cardiorenal syndrome (CRS) induced by prolonged hypertension.

    Methods: We used inbred male Dahl salt-sensitive (DS) rats fed an 8% NaCl diet from six weeks of age (high-salt; HS group) or a 0. Read More

    Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis.
    Sci Rep 2017 May 30;7(1):2519. Epub 2017 May 30.
    Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
    High serum uric acid (UA) level has been assumed to be a risk factor for left ventricular (LV) dysfunction; however, the precise relationship between these conditions has not been fully examined because many confounding factors are associated with UA level. We herein examined the precise relationship by proposing structural equation models. The study population consisted of 1432 cases with ischemic heart disease who underwent cardiac catheterization. Read More

    Efficacy of Rhesus Theta (θ)-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation.
    Antimicrob Agents Chemother 2017 May 30. Epub 2017 May 30.
    University of Southern California, School of Pharmacy, Los Angeles, CA
    Rationale: Chronic airway infection and inflammation contribute to the progressive loss of lung function and shortened survival of patients with cystic fibrosis (CF). Rhesus theta (θ) defensin-1 (RTD-1) is a macrocyclic host defense peptide with antimicrobial and immunomodulatory activities. Combined with favorable preclinical safety and peptide stability data, RTD-1 warrants investigation to determine its therapeutic potential for treatment of CF lung disease. Read More

    Pro-angiogenic TIE-2-expressing monocytes/TEMs as a biomarker of the effect of sorafenib in patients with advanced hepatocellular carcinoma.
    Int J Cancer 2017 May 27. Epub 2017 May 27.
    Department of Liver Disease, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
    Sorafenib, a multi-kinase inhibitor, inhibits tumor angiogenesis and is the first-line systemic therapy for patients with advanced hepatocellular carcinoma (HCC). However, due to its limited effects and frequent occurrence of side effects, biomarkers are needed to predict the effects of sorafenib. We considered the possibility of using TIE-2-expressing monocytes (TEMs) to predict the response in sorafenib-treated patients with advanced HCC. Read More

    Microtubule-associated protein tau contributes to intra-dendritic trafficking of AMPA receptors in multiple.
    Neurosci Lett 2017 May 26;653:276-282. Epub 2017 May 26.
    Department of Aging Neurobiology, National Center for Geriatrics and Gerontology, Obu-shi, Aichi, Japan; Department of Alzheimer's Disease Research, National Center for Geriatrics and Gerontology, Obu-shi, Aichi, Japan. Electronic address:
    Microtubule-associated protein tau has crucial roles not only in the formation of some neurodegenerative disorders but also in normal synaptic functions, although its contributions to these are still unclear. Here, to reveal the influence of tau deletion on trafficking of synaptic receptors, we investigated the distribution of GluA2-containing AMPA-type glutamate receptors (AMPARs) within neuronal dendrites in wild-type and tau-deficient neurons using biochemical and laser-confocal imaging techniques. Under basal conditions, expression of GluA2 at tau-deficient synapses was almost normal; however, its level within dendrites in tau-deficient neurons was greater than that in wild-type neurons. Read More

    The significance of tumor-associated neutrophil density in uterine cervical cancer treated with definitive radiotherapy.
    Gynecol Oncol 2017 Jun;145(3):469-475
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
    Objective: The aim of this study was to investigate the prognostic significance of tumor-associated neutrophil (TAN) density in cervical cancer patients that were treated with definitive radiotherapy.

    Methods: The baseline characteristics and outcome data of FIGO stages IB-IVA cervical cancer patients who were treated with definitive radiotherapy between January 1996 and December 2011 were collected. Using biopsy samples obtained at the time of the initial diagnosis, the expression levels of CD66b in the patients' cervical tumors were evaluated by immunohistochemistry. Read More

    The efficacy of surgical treatment of recurrent or persistent cervical cancer that develops in a previously irradiated field: a monoinstitutional experience.
    Int J Clin Oncol 2017 May 27. Epub 2017 May 27.
    Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
    Background: There are no guidelines about the selection of recurrent cervical cancer patients for salvage surgery.

    Methods: Patients who developed recurrent or persistent cervical cancer in a previously irradiated field and were subsequently treated with salvage surgery (the surgery group) or palliative care alone (the palliative group) were identified. Patient characteristics, treatment-related complications, and survival were retrospectively compared between the two groups. Read More

    Randomized Controlled Trial of Adjuvant Chemotherapy with Fluoropyrimidines Versus Surgery-alone for Gastric Cancer.
    Anticancer Res 2017 06;37(6):3061-3067
    Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
    Aim: This prospective randomized study compared the survival of patients with stage IB-IIIA gastric cancer treated with surgery alone or surgery followed by adjuvant chemotherapy.

    Patients And Methods: Patients with pathological stage IB-IIIA disease were randomly assigned to the following groups: surgery alone (n=116), or surgery followed by adjuvant chemotherapy with 5-fluorouracil, doxifluridine, or uracil-tegafur for 12 months (n=113).

    Results: The overall survival rate was 86. Read More

    Radical operation for hilar cholangiocarcinoma in comparable Eastern and Western centers: Outcome analysis and prognostic factors.
    Surgery 2017 May 24. Epub 2017 May 24.
    Department of HPB and Transplant Surgery, St. James's University Hospital NHS Trust, Leeds, UK. Electronic address:
    Background: Extensive resection for hilar cholangiocarcinoma is the most effective treatment, but high morbidity and poor prognosis remain concerns. Previous data have shown marked differences in outcomes between comparable Eastern and Western centers. We compared the outcomes of the management for hilar cholangiocarcinoma at one Japanese and one British institution with comparable experience. Read More

    Validation of the cingulate island sign with optimized ratios for discriminating dementia with Lewy bodies from Alzheimer's disease using brain perfusion SPECT.
    Ann Nucl Med 2017 May 25. Epub 2017 May 25.
    Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8551, Japan.
    Objective: Dementia with Lewy bodies (DLB) is often cited as the second most common dementia after Alzheimer's disease (AD). It is clinically important to distinguish DLB from AD because specific side effects of antipsychotic drugs are limited to DLB. The relative preservation of cingulate glucose metabolism in the posterior cingulate gyri versus that in the precuni, known as the cingulate island sign (CIS), in patients with DLB compared with AD is supposed to be highly specific for diagnosing DLB. Read More

    Targeting nuclear receptors for the treatment of fatty liver disease.
    Pharmacol Ther 2017 May 23. Epub 2017 May 23.
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
    Ligand-activated nuclear receptors, including peroxisome proliferator-activated receptor alpha (PPARα), pregnane X receptor, and constitutive androstane receptor, were first identified as key regulators of the responses against chemical toxicants. However, numerous studies using mouse disease models and human samples have revealed critical roles for these receptors and others, such as PPARβ/δ, PPARγ, farnesoid X receptor (FXR), and liver X receptor (LXR), in maintaining nutrient/energy homeostasis in part through modulation of the gut-liver-adipose axis. Recently, disorders associated with disrupted nutrient/energy homeostasis, e. Read More

    Clinical outcomes of stereotactic body radiotherapy for elderly patients with hepatocellular carcinoma.
    Hepatol Res 2017 May 20. Epub 2017 May 20.
    Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.
    Aim: To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of hepatocellular carcinoma (HCC) in elderly patients.

    Methods: From 2008 to 2015, 117 patients with HCC (≤3 nodules, ≤30 mm in diameter, Child-Pugh score ≤7, and no vascular or extracellular metastasis) were treated with SBRT at our hospital. We evaluated overall survival (OS), disease-free survival (DFS), local control, and adverse events. Read More

    Feasibility study of adjuvant chemotherapy with modified weekly nab-paclitaxel and carboplatin for completely resected non-small-cell lung cancer: FAST-nab.
    Anticancer Drugs 2017 May 19. Epub 2017 May 19.
    Department of Chest Surgery, St Marianna University School of Medicine, Kawasaki, Japan.
    The aim of this study was to determine the feasibility of adjuvant administration of nab-paclitaxel (nab-P) plus carboplatin and for completely resected patients with stage IB, II, and IIIA non-small-cell lung cancer (NSCLC) (FAST-nab study, UMIN000011225). Twenty-nine eligible NSCLC patients received surgical resection for pathological stage IB, II, or IIIA, followed by postoperative adjuvant chemotherapy with modified 3-week cycles of either nab-P (100 mg/m) on days 1 and 8, followed by carboplatin area (area under the curve=6) on day 1. Twenty-two (75. Read More

    [Clinical Experience of S-1 and Oxaliplatin(SOX)as the First-Line Chemotherapy for Metastatic/Recurrent Gastric Cancer].
    Gan To Kagaku Ryoho 2017 May;44(5):405-408
    Dept. of Surgical Oncology, Osaka City University Graduate School of Medicine.
    We retrospectively investigated the efficacy and safety of S-1 and oxaliplatin(SOX)as the first-line chemotherapy in patients with metastatic/recurrent gastric cancer. A total of 27 patients who received SOX as the first-line chemotherapy in our hospital were considered for the study. The SOX chemotherapy schedule consisted of 1 course every 3 weeks. Read More

    Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease.
    N Engl J Med 2017 05;376(20):1933-1942
    From the Cleveland Clinic Coordinating Center for Clinical Research (C5Research), Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland (A.M.L., V.M., E.M., K.W., D.M., S.E.N.); South Australian Heart and Medical Research Institute, University of Adelaide, Adelaide (S.J.N.), and School of Medical Sciences, University of New South Wales, Sydney (P.J.B.) - both in Australia; Eli Lilly, Indianapolis (J.S.R., G.R., B.V., G.W.); Washington Cardiovascular Associates, Medstar Research Institute, Washington, DC (H.B.B.); Centre for Cardiovascular Science, University of Edinburgh, Edinburgh (K.A.A.F.); Beth Israel Deaconess Medical Center, Boston (C.M.G.); Duke University Medical Center, Durham, NC (C.G.); Université Sorbonne Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Institut de Cardiologie, Paris (G.M.); Penn Heart and Vascular Center, Philadelphia (D.R.); Columbia University, New York (A.R.T.), and Saratoga Cardiology Associates, Saratoga Springs (D.K.) - both in New York; St. Michael's Hospital, Toronto (S.G.), Recherche Médicale Saint-Jérôme, Saint-Jérôme, QC (Y.P.), and Centre de Santé et de Services Sociaux du Nord de Lanaudière-Centre Hospitalier Régional de Lanaud, Saint-Charles-Borromée, QC (S.K.) - all in Canada; Instituto Cardiovascular de Buenos Aires, Buenos Aires (D.C.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Heart Institute (InCor)-University of São Paulo Medical School, São Paulo (J.C.N.); Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosi, Mexico (J.L.L.-P.); the First Affiliated Hospital of Harbin Medical University, Harbin, China (W.L.); and South Oklahoma Heart Research, Oklahoma City (N.T.).
    Background: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease.

    Methods: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Read More

    Angiolymphoid Hyperplasia with Eosinophilia Involving the Occipital Artery: Case Report and Review of Literature.
    J Clin Diagn Res 2017 Mar 1;11(3):ZD21-ZD23. Epub 2017 Mar 1.
    Head, Department of Oral and Maxillofacial Surgery, Vall d'Hebrón Hospital. Barcelona, Spain.
    Angiolymphoid Hyperplasia with Eosinophilia (ALHE) is an atypical vascular tumour occurring primarily in the head and neck area, which must be distinguished from Kimura's disease. The lesions can appear as single or multiple grouped intradermal papules or subcutaneous nodules. We report a rare case of ALHE in a 57-year-old female with a large lesion of three nodules involving the right occipital artery which had a long term evolution and we treated it by surgical excision. Read More

    Long-chain fatty acid triglyceride (TG) metabolism disorder impairs male fertility: a study using adipose triglyceride lipase deficient mice.
    Mol Hum Reprod 2017 May 16. Epub 2017 May 16.
    Department of Obstetrics and Gynaecology, Osaka University Graduate School of Medicine, Suita, Osaka5650871, Japan.
    Study Question: Does the deletion of adipose triglyceride lipase (Atgl) gene impair male fertility?

    Summary Answer: The deletion of Atgl gene impaired male fertility but the effect was partially reversed by a low long chain triglyceride (TG) diet.

    What Is Known Already: ATGL specifically hydrolyses long-chain fatty acid triglyceride (TG) to diacylglycerol and a high level of expression of ATGL in testes has been reported. However, the role of ATGL in male fertility is unknown. Read More

    RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease.
    J Stroke Cerebrovasc Dis 2017 May 11. Epub 2017 May 11.
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Background: This study aimed to determine the effectiveness of genetic testing for the p.R4810K variant (rs112735431) of the Mysterin/RNF213 gene, which is associated with moyamoya disease and other intracranial vascular diseases, in the family members of patients with moyamoya disease.

    Methods: We performed genotyping of the RNF213 p. Read More

    [A Clinicopathologic Study of 6 Patients with Histologically Pure Seminoma But Elevated Serum Alpha-Fetoprotein].
    Hinyokika Kiyo 2017 Apr;63(4):139-143
    The Department of Urology, Faculty of Medicine, University of Tsukuba.
    Histologically pure seminoma with elevated alpha-fetoprotein (AFP), so-called AFP-positive seminoma, is rare. It is recommended that patients with AFP-positive seminoma be managed as non-seminoma, but the clinical features and prognosis of this disease are not fully understood. In this study, we retrospectively analyzed 6 cases of metastatic AFP-positive seminoma at Tsukuba University Hospital (TUH). Read More

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