8,793 results match your criteria Kimura Disease


Feasibility of transnasal flexible carbon dioxide laser surgery for laryngopharyngeal lesions.

Auris Nasus Larynx 2019 Feb 11. Epub 2019 Feb 11.

Department of Otolaryngology - Head & Neck Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.

Objective: The fiber-guided carbon dioxide (CO) laser is a useful device for laryngopharyngeal surgery. The flexible CO wave-guide laser has been developed and commercially available for several years. However, the transnasal use of CO flexible wave-guided laser surgery through the instrument channel of a flexible endoscope (CO TNFLS) is not permitted in Japan. Read More

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http://dx.doi.org/10.1016/j.anl.2019.01.008DOI Listing
February 2019

Hypochondriasis in the elderly and Lewy body disease.

Psychogeriatrics 2019 Feb 13. Epub 2019 Feb 13.

Departments of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.1111/psyg.12425DOI Listing
February 2019

Beneficial Effect of Early Intervention with Garenoxacin for Bacterial Infection-Induced Acute Exacerbation of Bronchial Asthma and Chronic Obstructive Pulmonary Disease.

Int Arch Allergy Immunol 2019 Feb 13:1-8. Epub 2019 Feb 13.

Division of Allergology and Respiratory Medicine, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

Background: Chronic obstructive pulmonary disease (COPD) and asthma have similar clinical features and are both exacerbated by airway infection.

Objective: To determine whether garenoxacin mesylate hydrate (GRNX) added to the standard care for bacterial infection-induced acute exacerbation of asthma or COPD in adults has clinical benefits.

Method: This single-arm clinical trial was conducted from January 2015 to March 2016. Read More

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http://dx.doi.org/10.1159/000495761DOI Listing
February 2019

C/EBPβ is a critical mediator of IFN-α-induced exhaustion of chronic myeloid leukemia stem cells.

Blood Adv 2019 Feb;3(3):476-488

Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.

Even in the era of ABL tyrosine kinase inhibitors, eradication of chronic myeloid leukemia (CML) stem cells is necessary for complete cure of the disease. Interferon-α (IFN-α) has long been used for the treatment of chronic-phase CML, but its mechanisms of action against CML stem cells remain unclear. We found that IFN-α upregulated CCAAT/enhancer binding protein β (C/EBPβ) in BCR-ABL-expressing mouse cells by activating STAT1 and STAT5, which were recruited to a newly identified 3' distal enhancer of that contains tandemly aligned IFN-γ-activated site elements. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018020503DOI Listing
February 2019

Surveillance Colonoscopy for Ulcerative Colitis-Associated Colorectal Cancer Offers Better Overall Survival in Real-World Surgically Resected Cases.

Am J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Internal Medicine, Sakura Medical Center, Toho University, Tokyo, Japan.

Objectives: To determine the effectiveness of surveillance colonoscopy (SC) and optimize its use by assessing real-world surgically resected cases of ulcerative colitis (UC)-associated colorectal cancer (CRC) and dysplasia.

Methods: Clinicopathological data of 406 (238 CRC and 168 dysplasia) patients who underwent surgical resection in 10 UC specialized institutions were retrospectively reviewed. The overall survival (OS) rates were compared between the SC and non-SC groups. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000117DOI Listing
February 2019

Impact of the Temporal Distribution of Coronary Artery Disease Progression on Subsequent Consequences in Patients with Acute Coronary Syndrome.

Int Heart J 2019 Feb 8. Epub 2019 Feb 8.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine.

The late consequences of acute coronary syndrome (ACS) have been underestimated. We hypothesized that the temporal distribution of the clinically silent coronary artery disease progression (CP) is associated with the subsequent consequences of ACS.We studied 243 patients (202 men, 64 ± 10 years) with ACS undergoing percutaneous coronary intervention (PCI) during initial hospitalization. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-394DOI Listing
February 2019
2 Reads

Addition of radium-223 to abiraterone acetate and prednisone or prednisolone in patients with castration-resistant prostate cancer and bone metastases (ERA 223): a randomised, double-blind, placebo-controlled, phase 3 trial.

Lancet Oncol 2019 Feb 6. Epub 2019 Feb 6.

University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Abiraterone acetate plus prednisone or prednisolone improves progression-free survival and overall survival in patients with metastatic castration-resistant prostate cancer. Radium-223 improves overall survival and delays the onset of symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases. We assessed concurrent treatment with abiraterone acetate plus prednisone or prednisolone and radium-223 in such patients. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30860-XDOI Listing
February 2019
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Perioperative blood transfusion affects oncologic outcomes after nephrectomy for renal cell carcinoma: A systematic review and meta-analysis.

Urol Oncol 2019 Feb 5. Epub 2019 Feb 5.

Department of Urology, Medical University of Vienna, Vienna, Austria; Department of Urology, Weill Cornell Medical College, New York, NY; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria. Electronic address:

Aim: To investigate the association of perioperative blood transfusion (PBT) with oncologic outcomes in patients with renal cell carcinoma (RCC), we conducted a systematic review and meta-analysis of the literature to clarify the long-term oncologic effect of PBT in patients undergoing nephrectomy for RCC.

Materials And Methods: We searched the MEDLINE, Web of Science, Cochrane Library and Scopus on 15th April 2018 to identify studies that compared patients who received PBT undergoing radical or partial nephrectomy for RCC to patients who did not with the aim of evaluating its impact on overall mortality (OM), cancer-specific mortality (CSM) and disease recurrence using multivariable cox regression analysis.

Results: A total of 19,681 patients in 7 studies matched the selection criteria for the systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.018DOI Listing
February 2019
1 Read

A Homozygous Mutation in a Japanese Patient with Catecholaminergic Polymorphic Ventricular Tachycardia.

Case Rep Genet 2019 8;2019:9056596. Epub 2019 Jan 8.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

A 62-year-old female had suffered from recurrent syncopal episodes triggered by physical and emotional stress since childhood. She had no family history of sudden death. An intensive examination could not detect any structural disease, and exercise stress testing provoked polymorphic ventricular ectopy followed by polymorphic ventricular tachycardia accompanied with syncope leading to a diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT). Read More

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https://www.hindawi.com/journals/crig/2019/9056596/
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http://dx.doi.org/10.1155/2019/9056596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341267PMC
January 2019
2 Reads

Association between Prescription and Control Status of Dyslipidemia and Hypertension among Japanese Patients with Diabetes.

J Atheroscler Thromb 2019 Feb 6. Epub 2019 Feb 6.

Department of Internal Medicine, Teikyo University.

Aims: The proper management of atherosclerotic risk factors (ARFs) and attainment of target levels (TLs) for ARFs are crucial in preventing atherosclerotic cardiovascular disease (ASCVD). In this study, utilizing data from the "Specific Health Check and Guidance in Japan," which was conducted from 2008 to 2011, we examined TL attainment status of low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) and prescription status of dyslipidemia and hypertension in patients with diabetes undergoing medical treatment, and analyzed the factors that affected prescription status.

Methods: Subjects receiving medical treatment for diabetes were selected from the database. Read More

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http://dx.doi.org/10.5551/jat.47597DOI Listing
February 2019
1 Read

Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta-thalassemia.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of General Internal Medicine, Hiroshima University Hospital, Japan.

Acute chest syndrome (ACS), characterized by fever, respiratory symptoms, and new pulmonary infiltration, is a serious complication of sickle cell disease (SCD). Regardless of the etiology, the conventional treatment options for ACS include empirical antibiotic therapy, the administration of analgesics, and red cell transfusion. The indications and methods of red cell transfusion are critical. Read More

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http://dx.doi.org/10.2169/internalmedicine.1753-18DOI Listing
February 2019
2 Reads

Analysis of synergy between beta-lactams and anti-methicillin-resistant Staphylococcus aureus agents from the standpoint of strain characteristics and binding action.

J Infect Chemother 2019 Jan 31. Epub 2019 Jan 31.

Department of Microbiology and Infectious Disease, Toho University School of Medicine, Tokyo, Japan. Electronic address:

In light of the increasing number of clinical cases resistant to traditional monotherapies and the lack of novel antimicrobial agents, combination therapy is an appealing solution for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we evaluated the efficacy of anti-MRSA agents, such as vancomycin (VAN), daptomycin (DAP), and linezolid (LZD), in conjunction with 13 beta-lactams and non-beta-lactams. We assessed the in vitro activities of the various combinations against 40 MRSA strains based on the maximum synergistic effect (MSE), an index calculated from the MIC change with a combination agent. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.12.007DOI Listing
January 2019
1 Read

An unexpected asymptomatic epiglottal site of Kimura disease.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Feb 26;136(1):47-49. Epub 2018 Oct 26.

Internal Medicine Department, Victor Provo Hospital, 11, boulevard Lacordaire, 59100 Roubaix, France.

Introduction: Kimura disease (KD) is a chronic lymphoproliferative disorder of unknown etiology that affects the skin and lymph nodes, mostly observed in males of Asian descent. The natural history of asymptomatic epiglottal KD remains unknown. This rare site of KD is often only diagnosed when tumor growth starts to obstruct the upper airways. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.10.008DOI Listing
February 2019
2 Reads

Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer.

Anticancer Res 2019 Feb;39(2):1029-1034

Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan.

Aim: This study aimed to clarify the tolerability of a trifluridine/tipiracil combination tablet (TAS-102) in patients with advanced or recurrent colorectal cancer over 75 years of age.

Patients And Methods: Patients were divided into groups under the age of 75 years (n=62), and 75 years and over (n=17). The treatment period with TAS-102 tablet, reasons for discontinuation, adverse events (AEs), and overall survival (OS) were compared between the groups. Read More

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http://dx.doi.org/10.21873/anticanres.13209DOI Listing
February 2019
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No association between fruits or vegetables and non-alcoholic fatty liver disease in middle-aged men and women.

Nutrition 2018 Oct 23;61:119-124. Epub 2018 Oct 23.

Department of Nutrition and Food Science, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan; The Institute for Human Life Innovation, Ochanomizu University, Tokyo, Japan. Electronic address:

Objective: It has been hypothesized that fruit and vegetable intake is inversely associated with non-alcoholic fatty liver (NAFLD). However, some studies have speculated that fruit intake might be positively associated with NAFLD owing to the fructose content of the fruit. This might cause consumers to hesitate consuming fruit. Read More

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http://dx.doi.org/10.1016/j.nut.2018.10.016DOI Listing
October 2018
1 Read

Dual wavelength 5-aminolevulinic acid photodynamic therapy using a novel flexible light-emitting diode unit.

J Dermatol Sci 2019 Jan 10. Epub 2019 Jan 10.

Department of Geriatric and Environmental Dermatology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan. Electronic address:

Background: Photosensitizers used for photodynamic therapy (PDT) to treat dermatologic disease are metabolized into mainly protoporphyrin IX (PpIX), which has five absorption wavelength peaks: 410 nm, 510 nm, 545 nm, 580 nm, and 630 nm. Although only red light around 635 nm and blue light around 400 nm are used as light sources for PDT, the efficiency of PDT might be improved by using multiple wavelengths, including those that correspond to the other absorption peaks of PpIX. Furthermore, because the target disease often occurs on the face, a flexible-type light-source unit that can be fitted to the lesion without unnecessarily exposing the mucous membranes, e. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.12.006DOI Listing
January 2019

Pathomorphological features of metastatic lymph nodes as predictors of postoperative prognosis in pancreatic cancer.

Medicine (Baltimore) 2019 Feb;98(5):e14369

Department of Surgery, New Tokyo Hospital, 1271 Wanagaya, Matsudo, Chiba.

To investigate the pathological features of metastatic lymph nodes (LN) in pancreatic ductal adenocarcinoma (PDAC) and to determine factors with prognostic implications.Metastatic LN status is a proven significant factor for predicting postoperative prognosis in pancreatic cancer patients. However, the effective prognostic criteria regarding metastatic LNs for such disease remain unknown. Read More

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http://dx.doi.org/10.1097/MD.0000000000014369DOI Listing
February 2019

Critical Role of SREBP (Sterol Regulatory Element-Binding Protein)-1c Large-VLDL (Very Low-Density Lipoprotein) Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency.

Arterioscler Thromb Vasc Biol 2019 Jan 31:ATVBAHA118311931. Epub 2019 Jan 31.

From the Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Japan (Mikio Takanashi, T. Kimura, C.L., A.M., H. Yoshida, A.N., P.X., S.T., S.O., Y. Iizuka, T.G., T.Y., T. Kadowaki, H.O.).

Objective- APOA5 variants are strongly associated with hypertriglyceridemia, as well as increased risks of cardiovascular disease and acute pancreatitis. Hypertriglyceridemia in apo AV dysfunction often aggravates by environmental factors such as high-carbohydrate diets or aging. To date, the molecular mechanisms by which these environmental factors induce hypertriglyceridemia are poorly defined, leaving the high-risk hypertriglyceridemia condition undertreated. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311931DOI Listing
January 2019
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Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study).

Ann Gastroenterol Surg 2019 Jan 11;3(1):96-103. Epub 2018 Oct 11.

Department of Gastroenterological Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

Aim: As a result of the difficulty in effective prevention of gastroesophageal reflux, no standard reconstruction procedure after proximal gastrectomy (PG) has yet been established. The double-flap technique (DFT), or Kamikawa procedure, is an antireflux reconstruction procedure in esophagogastrostomy. The efficacy of DFT has recently been reported in several studies. Read More

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http://dx.doi.org/10.1002/ags3.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345660PMC
January 2019
1 Read

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors.

Sci Rep 2019 Jan 29;9(1):913. Epub 2019 Jan 29.

Department of Systems Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

The derivation of kidney tissues from human pluripotent stem cells (hPSCs) and its application for replacement therapy in end-stage renal disease have been widely discussed. Here we report that consecutive transfections of two sets of synthetic mRNAs encoding transcription factors can induce rapid and efficient differentiation of hPSCs into kidney tissues, termed induced nephron-like organoids (iNephLOs). The first set - FIGLA, PITX2, ASCL1 and TFAP2C, differentiated hPSCs into SIX2SALL1 nephron progenitor cells with 92% efficiency within 2 days. Read More

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http://dx.doi.org/10.1038/s41598-018-37485-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351687PMC
January 2019

Angiolymphoid hyperplasia with eosinophilia: Two case reports.

Australas J Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Pathology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

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http://dx.doi.org/10.1111/ajd.12988DOI Listing
January 2019
2 Reads

Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma.

Cell Death Dis 2019 Jan 28;10(2):75. Epub 2019 Jan 28.

Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

N-acetylcysteine (NAC) is widely used as a mucolytic agent and as an antidote to paracetamol overdose. NAC serves as a precursor of cysteine and stimulates the synthesis of glutathione in neural cells. Suppressing oxidative stress in the retina may be an effective therapeutic strategy for glaucoma, a chronic neurodegenerative disease of the retinal ganglion cells (RGCs) and optic nerves. Read More

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http://www.nature.com/articles/s41419-019-1365-z
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http://dx.doi.org/10.1038/s41419-019-1365-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349904PMC
January 2019
3 Reads

Evidence Basis for a Point-of-Care Ultrasound Examination to Refine Referral for Outpatient Echocardiography.

Am J Med 2019 Feb 25;132(2):227-233. Epub 2018 Oct 25.

Department of Cardiology and Graduate Medical Education, Scripps Mercy Hospital, San Diego, Calif. Electronic address:

Background: Few data exist on the potential utility of a cardiac point-of-care ultrasound (POCUS) examination in the outpatient setting to assist diagnosis of significant cardiac disease. Using a retrospective sequential cohort design, we sought to derive and then validate a POCUS examination for cardiac application and model its potential use for prognostication and cost-effective echo referral.

Methods: For POCUS examination derivation, we reviewed 233 consecutive outpatient echo studies for 4 specific POCUS "signs" contained therein representing left ventricular systolic dysfunction, left atrial enlargement, inferior vena cava plethora, and lung apical B-lines. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.10.012DOI Listing
February 2019

Heart Transplantation Ameliorates Ambulation Capacity in Patients With Muscular Dystrophy - An Analysis of 9 Cases.

Circ J 2019 Jan 26. Epub 2019 Jan 26.

Department of Transplant Medicine, National Cerebral and Cardiovascular Center.

Background: Heart transplantation (HTx) is reported to have a comparable effect on the prognosis of heart failure patients without muscular disease and for those with muscular dystrophy (MD). However, little is known about the changes in muscular diseases in patients with MD after HTx. Methods and Results: We assessed the ambulatory capacity of 9 patients with MD who underwent HTx. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1060DOI Listing
January 2019
1 Read

Laparoscopic subtotal cholecystectomy for Mirizzi syndrome: A report of a case.

Int J Surg Case Rep 2019 Jan 19;55:32-34. Epub 2019 Jan 19.

Department of Surgery, Tokyo Bay Urayasu Ichikawa Medical Center, Chiba, Japan. Electronic address:

Introduction: Mirizzi syndrome is a rare complication of gallstone disease. The purpose of this report is to describe the utility of laparoscopic subtotal cholecystectomy for Mirizzi syndrome.

Presentation Of Case: A 53-year-old female presented with dark urine and right upper quadrant pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193002
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http://dx.doi.org/10.1016/j.ijscr.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351350PMC
January 2019
5 Reads

A CASE OF CAT SCRATCH DISEASE DIAGNOSED BY INDIRECT FLUORESCENT ANTIBODY ASSAY OF IGM SPECIFIC FOR A JAPANESE STRAIN OF Bartonella henselae.

Retin Cases Brief Rep 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Purpose: To report a case of cat scratch disease-associated retinitis diagnosed with an indirect fluorescent antibody (IFA) assay for immunoglobulin M (IgM) specific for a strain (YH-01) of Bartonella henselae recently identified in Japan.

Methods: Case report of a 24-year-old pregnant woman presented with general fever, fatigue, as well as blurred vision, and a central visual field deficiency in her right eye and was suspected as cat scratch disease because she had started to feed a feral dog a month ago.

Results: The patient's serum tested negative, however, with an IFA assay for IgG or IgM specific for the Houston-1, common strain of B. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000854DOI Listing
January 2019
2 Reads

Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1.

Neuropsychiatr Dis Treat 2019 14;15:219-226. Epub 2019 Jan 14.

Department of Clinical Research Support, Translational Medical Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan.

Purpose: Myotonic dystrophy type 1 (DM1) is a common form of muscular dystrophy that presents with a variety of symptoms that can affect patients' quality of life (QoL). Despite the importance of clarifying patients' subjective experience in both physical and psychosocial aspects for improved symptom management, there is lack of evidence concerning QoL of patients with DM1 in Japan.

Patients And Methods: A cross-sectional study was performed with 51 DM1 patients who completed questionnaires that measured health-related QoL (HRQoL), depression, and daytime sleepiness. Read More

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http://dx.doi.org/10.2147/NDT.S187607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338121PMC
January 2019

An 18-Year-Old Male With X-linked Lymphoproliferative Syndrome Type 1 Who Developed Primary Central Nervous System Lymphoma 6 Months After Primary Epstein-Barr Virus Infection.

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Departments of Pediatrics.

X-linked lymphoproliferative syndrome type 1 (XLP1) is a rare congenital immunodeficiency disease. We report the case of an 18-year-old male who developed hemophagocytic lymphohistiocytosis (HLH) with neurological complications after primary Epstein-Barr virus (EBV) infection and subsequently developed EBV-related central nervous system lymphoma (CNSL). Given the vulnerability to EBV, he was finally diagnosed with XLP1 and treated with whole-brain irradiation along with chemotherapy and subsequent allogeneic hematopoietic stem cell transplantation from a SH2D1A wild-type sibling donor. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001424DOI Listing
January 2019
4 Reads

Current status, problems, and perspectives of non-alcoholic fatty liver disease research.

World J Gastroenterol 2019 Jan;25(2):163-177

Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.

Non-alcoholic fatty liver disease (NAFLD) is a major chronic liver disease that can lead to liver cirrhosis, liver cancer, and ultimately death. NAFLD is pathologically classified as non-alcoholic fatty liver (NAFL) or non-alcoholic steatohepatitis (NASH) based on the existence of ballooned hepatocytes, although the states have been known to transform into each other. Moreover, since the detection of ballooned hepatocytes may be difficult with limited biopsied specimens, its clinical significance needs reconsideration. Read More

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http://dx.doi.org/10.3748/wjg.v25.i2.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337019PMC
January 2019
1 Read

Quantitative analysis of regional endocardial geometry dynamics from 4D cardiac CT images: endocardial tracking based on the iterative closest point with an integrated scale estimation.

Phys Med Biol 2019 Jan 22. Epub 2019 Jan 22.

Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate School of Medicine School of Medicine, Sapporo, JAPAN.

Regional cardiac function analysis is important for the diagnosis and treatment planning of ischemic heart disease, but has not been sufficiently developed in the field of computed tomography (CT). Therefore, we propose a three-dimensional endocardial tracking framework for cardiac CT using local point cloud registration based on the iterative closest point with an integrated scale estimation algorithm. We also introduce regional function descriptors that express the curvature and stretching of the endocardium: Surface distortion (E) and Scaling rate (S). Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab009a
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http://dx.doi.org/10.1088/1361-6560/ab009aDOI Listing
January 2019
4 Reads

Disrupted cortico-ponto-cerebellar pathway in patients with hemimegalencephaly.

Brain Dev 2019 Jan 18. Epub 2019 Jan 18.

Integrative Brain Imaging Center, National Center Hospital of Neurology and Psychiatry, Tokyo, Japan.

Objective: Cerebellar dysmaturation and injury is associated with a wide range of neuromotor, neurocognitive and behavioral disorders as well as with preterm birth. We used diffusion tensor MR imaging to investigate a disruption in structural cortico-ponto-cerebellar (CPC) connectivity in children with infantile-onset severe epilepsy.

Methods: We performed CPC tract reconstructions in 24 hemimegalencephaly (HME) patients, 28 West syndrome (WS) of unknown etiology patients, and 25 pediatric disease control subjects without a history of epilepsy nor brain abnormality on MRI. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.01.002DOI Listing
January 2019

Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Nat Microbiol 2019 Jan 21. Epub 2019 Jan 21.

Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Epstein-Barr virus (EBV) infection is highly prevalent in humans and is implicated in various diseases, including cancer. Chronic active EBV infection (CAEBV) is an intractable disease classified as a lymphoproliferative disorder in the 2016 World Health Organization lymphoma classification. CAEBV is characterized by EBV-infected T/natural killer (NK) cells and recurrent/persistent infectious mononucleosis-like symptoms. Read More

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http://dx.doi.org/10.1038/s41564-018-0334-0DOI Listing
January 2019
15 Reads

Overview of EBV-Associated T/NK-Cell Lymphoproliferative Diseases.

Front Pediatr 2018 4;6:417. Epub 2019 Jan 4.

Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative diseases (EBV-T/NK-LPDs) are a group of rare diseases resulting from ectopic infection of T or natural killer (NK) lymphocytes with Epstein-Barr virus (EBV). EBV-T/NK-LPDs include chronic active EBV infection, EBV-associated hemophagocytic lymphohistiocytosis, hydroa vacciniforme-like lymphoproliferative disease, and severe mosquito bite allergy. Extra-nodal NK/T-cell lymphoma-nasal type and aggressive NK-cell leukemia can also be included in this broad spectrum. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00417/
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http://dx.doi.org/10.3389/fped.2018.00417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328478PMC
January 2019
4 Reads

Real-World Postmarketing Study of the Impact of Adalimumab Treatment on Work Productivity and Activity Impairment in Patients with Psoriatic Arthritis.

Adv Ther 2019 Jan 19. Epub 2019 Jan 19.

Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Introduction: This study investigated the effectiveness of adalimumab treatment in improving Work Productivity and Activity Impairment (WPAI) in patients with psoriatic arthritis (PsA) in real-world settings in Japan.

Methods: This 24-week, single-arm, postmarketing surveillance study (2014-2017), conducted at 75 centers in Japan, enrolled adalimumab-naïve patients (paid workers, including part-time) meeting ClASsification criteria for Psoriatic ARthritis (CASPAR). The primary endpoint was improvement in overall work impairment (OWI) scores from baseline to week 24. Read More

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http://link.springer.com/10.1007/s12325-018-0866-y
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http://dx.doi.org/10.1007/s12325-018-0866-yDOI Listing
January 2019
18 Reads

Angiolymphoid hyperplasia with eosinophilia with clinical pictures of keratoacanthoma: A rare case report.

Clin Case Rep 2019 Jan 4;7(1):189-192. Epub 2018 Dec 4.

Sanglah General Public Hospital Denpasar Indonesia.

Angiolymphoid Hyperplasia with Eosinophilia (ALHE) is a benign tumor of the skin which may mimic other benign or malignant lesion of the skin. Practitioners should consider this diagnosis as a differential when encounter such lesion as papule or nodule on the face and scalp area. Read More

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http://dx.doi.org/10.1002/ccr3.1949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332754PMC
January 2019
1 Read

Temple syndrome diagnosed in an adult patient with clinical autism spectrum disorder.

Clin Case Rep 2019 Jan 8;7(1):15-18. Epub 2018 Nov 8.

Department of Pediatrics and Child Health Kurume University School of Medicine Kurume, Fukuoka Japan.

Temple syndrome (TS14) leads to growth failure, precocious puberty, and diabetes mellitus. However, the long-term prognosis, including the development of social behavior in TS14 patients, remains unclarified. We report the clinical course of a male patient with autism spectrum disorder that received a diagnosis of TS14 at 33 years of age. Read More

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http://doi.wiley.com/10.1002/ccr3.1895
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http://dx.doi.org/10.1002/ccr3.1895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332777PMC
January 2019
9 Reads

Fertility preservation in adolescent and young adult cancer patients: From a part of a national survey on oncofertility in Japan.

Reprod Med Biol 2019 Jan 20;18(1):97-104. Epub 2018 Nov 20.

Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki Japan.

Purpose: This study evaluated the current status of reproductive disorders and provision of information on oncofertility to female adolescent and young adult (AYA) cancer patients in Japan.

Methods: A national survey of AYA cancer survivors was conducted. Children were <15 years old, and AYAs were 15-39 years old. Read More

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http://dx.doi.org/10.1002/rmb2.12256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332751PMC
January 2019
2 Reads

Resilience in Carers of People With Young-Onset Alzheimer Disease.

J Geriatr Psychiatry Neurol 2019 Jan 16:891988718824039. Epub 2019 Jan 16.

1 Center for Alzheimer's Disease and Related Disorders, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Young-onset Alzheimer disease (YOAD) causes psychological and emotional difficulties for carers. However, even in the face of considerable caregiving demands and burden, some carers are resistant to stress, which may be a sign of resilience. This study investigated whether the clinical symptoms of the person with YOAD might be associated with resilience in their carers. Read More

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http://dx.doi.org/10.1177/0891988718824039DOI Listing
January 2019
2 Reads

Role of IL-10 in inhibiting protective immune responses against infection with heterologous Plasmodium parasites.

Parasitol Int 2019 Jan 9;70:5-15. Epub 2019 Jan 9.

Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan; Program for Nurturing Global Leaders in Tropical and Emerging Infectious Diseases, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan; Department of Immunology, School of Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan; Graduate School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Electronic address:

Malaria is induced by infection with Plasmodium parasites, which are genetically diverse, and the immune response to Plasmodium infection has both allele-specific and cross-reactive components. To determine the role of the cross-reactive immune response in the protection and disease manifestation in heterologous Plasmodium infection, we used infection models of P. chabaudi chabaudi (Pcc) and P. Read More

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http://dx.doi.org/10.1016/j.parint.2019.01.003DOI Listing
January 2019

Hyperchloremia Is Not an Independent Risk Factor for Postoperative Acute Kidney Injury in Pediatric Cardiac Patients.

J Cardiothorac Vasc Anesth 2018 Dec 5. Epub 2018 Dec 5.

Department of Anesthesiology and Resuscitation, Okayama University Hospital, Okayama, Japan.

Objective: Hyperchloremia recently has been shown to have an association with the development of acute kidney injury (AKI) in critically ill patients. However, there is little information about the prevalence of an abnormal chloride concentration after pediatric cardiac surgery and its association with postoperative AKI. The aim of this study was to determine the prevalence of hyperchloremia and its association with AKI in pediatric patients after cardiac surgery. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.12.009DOI Listing
December 2018
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Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion.

Neuron 2019 Feb 9;101(3):472-485.e7. Epub 2019 Jan 9.

Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Minimal sets of transcription factors can directly reprogram somatic cells into neurons. However, epigenetic remodeling during neuronal reprogramming has not been well reconciled with transcriptional regulation. Here we show that NeuroD1 achieves direct neuronal conversion from mouse microglia both in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.neuron.2018.12.010DOI Listing
February 2019

Thoracic Endovascular Aortic Repair for Pseudoaneurysm after Interrupted Aortic Arch Repair.

Ann Vasc Dis 2018 Dec;11(4):549-552

Department of Cardiovascular Surgery, Keio University School of Medicine, Tokyo, Japan.

Here we describe the case of a 33-year-old woman who was diagnosed with interrupted aortic arch (IAA) type A and who underwent radical surgery in her infancy. She developed a 42-mm anastomotic pseudoaneurysm in the distal aortic arch. We decided to perform thoracic endovascular aortic repair because of the patient's special request to avoid open surgery. Read More

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http://dx.doi.org/10.3400/avd.cr.18-00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326041PMC
December 2018

Toxicologic Pathology Forum: Current Status on the Use of Animal Models of Human Disease in the Pharmaceutical Industry in Japan in Nonclinical Safety Assessment-Opinion Paper.

Toxicol Pathol 2019 Jan 13:192623318816669. Epub 2019 Jan 13.

1 Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association, Chuo-ku, Tokyo, Japan.

In nonclinical safety studies for new drug development, healthy animals have been commonly used. However, in some cases, the use of animal models of human disease is considered to be more favorable in evaluating risks in patients. To elucidate the current status of the use of animal models for nonclinical safety assessment, an internal questionnaire from the Japan Pharmaceutical Manufacturers Association and surveys (questionnaire period: August 27 to September 30, 2015) of both common technical documents and review reports of approved drugs (approval period: May 1999 to May 2017) disclosed by the Pharmaceutical and Medical Devices Agency were conducted. Read More

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http://dx.doi.org/10.1177/0192623318816669DOI Listing
January 2019
2 Reads

Epidemiological and clinical analyses of cervical cancer using data from the population-based Osaka cancer registry.

Cancer Res 2019 Jan 11. Epub 2019 Jan 11.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine.

Cervical cancer screening rate is extremely low and the governmental recommendation of HPV vaccine has been suspended for 5years in Japan. Here we utilize data from the Osaka Cancer Registry, collected between 1976 and 2012, to evaluate cervical cancer trends in Japan. Age-adjusted incidence, relative survival, and conditional survival rates were calculated using multiple imputation methods and period analyses in 25,826 cervical cancer cases. Read More

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-3109DOI Listing
January 2019
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The use of next generation sequencing for improving food safety: Translation into practice.

Food Microbiol 2019 Jun 17;79:96-115. Epub 2018 Nov 17.

Gastrointestinal Bacteria Reference Unit, National Infection Service, Public Health England, 61 Colindale Avenue, London, NW9 5EQ, United Kingdom. Electronic address:

Next Generation Sequencing (NGS) combined with powerful bioinformatic approaches are revolutionising food microbiology. Whole genome sequencing (WGS) of single isolates allows the most detailed comparison possible hitherto of individual strains. The two principle approaches for strain discrimination, single nucleotide polymorphism (SNP) analysis and genomic multi-locus sequence typing (MLST) are showing concordant results for phylogenetic clustering and are complementary to each other. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07400020183053
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http://dx.doi.org/10.1016/j.fm.2018.11.005DOI Listing
June 2019
10 Reads

The Fate of Transplanted Periodontal Ligament Stem Cells in Surgically Created Periodontal Defects in Rats.

Int J Mol Sci 2019 Jan 7;20(1). Epub 2019 Jan 7.

Ochanomizu University, 2-1-1, Otsuka, Bunkyo-Ku, Tokyo 112-8610, Japan.

Periodontal disease is chronic inflammation that leads to the destruction of tooth-supporting periodontal tissues. We devised a novel method ("cell transfer technology") to transfer cells onto a scaffold surface and reported the potential of the technique for regenerative medicine. The aim of this study is to examine the efficacy of this technique in periodontal regeneration and the fate of transplanted cells. Read More

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http://dx.doi.org/10.3390/ijms20010192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337301PMC
January 2019

Association Between Appetite and Sarcopenia in Patients With Mild Cognitive Impairment and Early-Stage Alzheimer's Disease: A Case-Control Study.

Front Nutr 2018 18;5:128. Epub 2018 Dec 18.

Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan.

Sarcopenia is frequently seen in patients with mild cognitive impairment (MCI) and early-stage Alzheimer's disease (AD). While appetite loss and physical inactivity, which are also frequently seen in dementia, appear to contribute to sarcopenia, to date, no study has investigated this association. The aim of this study was to examine factors associated with sarcopenia, including appetite and physical activity, in patients with MCI and early-stage AD. Read More

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http://dx.doi.org/10.3389/fnut.2018.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305366PMC
December 2018
1 Read

Usefulness Differs Between the Visual Assessment and Specific Binding Ratio of I-Ioflupane SPECT in Assessing Clinical Symptoms of Drug-Naïve Parkinson's Disease Patients.

Front Aging Neurosci 2018 20;10:412. Epub 2018 Dec 20.

Department of Neurology, School of Medicine, Showa University, Tokyo, Japan.

In clinical practice, assessment of the striatal accumulation in I-ioflupane single photon emission computed tomography (SPECT) is commonly performed calculating the specific binding ratio (SBR) for the whole striatum. On the other hand, visual assessment of striatal accumulation in the SPECT was recently established. However, correlations of visual assessment with motor and cognitive functions in Parkinson's disease (PD) have rarely been examined. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306624PMC
December 2018

Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein.

J Clin Neurol 2019 Jan;15(1):62-67

Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background And Purpose: Disruption of nucleoporins has been reported in the motor neurons of patients with sporadic amyotrophic lateral sclerosis (sALS). However, the precise changes in the morphology of nucleoporins associated with the pathology of the 43-kDa TAR DNA-binding protein (TDP-43) in the disease process remain unknown. We investigated the expression of nucleoporins that constitute the nuclear pore complex (NPC) in spinal motor neurons that exhibit sALS in relation to TDP-43 pathology, which is a reliable neuropathological hallmark of sALS. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3988/jcn.2019.15
Publisher Site
http://dx.doi.org/10.3988/jcn.2019.15.1.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325357PMC
January 2019
6 Reads