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    Publisher Correction: Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle.
    Sci Rep 2018 Jan 19;8(1):1470. Epub 2018 Jan 19.
    Institute of Agrobiological Sciences, NARO, Ikenodai 2, Tsukuba, Ibaraki, 305-8602, Japan.
    A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. Read More

    Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing.
    Sci Rep 2018 Jan 19;8(1):1189. Epub 2018 Jan 19.
    Department of Systems Medicine, Keio University School of Medicine, Tokyo, 160, Japan.
    Direct generation of skeletal muscle cells from human pluripotent stem cells (hPSCs) would be beneficial for drug testing, drug discovery, and disease modelling in vitro. Here we show a rapid and robust method to induce myogenic differentiation of hPSCs by introducing mRNA encoding MYOD1 together with siRNA-mediated knockdown of POU5F1 (also known as OCT4 or OCT3/4). This integration-free approach generates functional skeletal myotubes with sarcomere-like structure and a fusion capacity in several days. Read More

    Two-year results after coronary stenting of small vessels in Japanese population using 2.25-mm diameter sirolimus-eluting stent with bioresorbable polymer: primary and long-term outcomes of CENTURY JSV study.
    Cardiovasc Interv Ther 2018 Jan 18. Epub 2018 Jan 18.
    Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan.
    Percutaneous coronary intervention (PCI) in coronary artery disease (CAD) with very small vessels remains challenging. The aim of this study is to evaluate the safety and effectiveness of the 2.25-mm diameter Ultimaster sirolimus-eluting stent in the treatment of Japanese patients with CAD due to lesions in very small vessels. Read More

    Higher levels of progranulin in cerebrospinal fluid of patients with lymphoma and carcinoma with CNS metastasis.
    J Neurooncol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, 1-1 Gifu, Yanagido, Gifu, 501-1194, Japan.
    Assessing central nervous system (CNS) involvement in patients with lymphoma or carcinoma is important in determining therapy and prognosis. Progranulin (PGRN) is a secreted glycosylated protein with roles in cancer growth and survival; it is highly expressed in aggressive cancer cell lines and specimens from many cancer types. We examined PRGN levels by Enzyme Immuno-Assay (EIA) in cerebrospinal fluid (CSF) samples from 230 patients, including 18 with lymphoma [12 with CNS metastasis (CNS+); 6 without CNS metastasis (CNS-)], 21 with carcinomas (10 CNS+; 11 CNS-), and 191 control patients with non-cancer neurological diseases, and compared PRGN levels among these disease groups. Read More

    Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome.
    Sci Rep 2018 Jan 16;8(1):819. Epub 2018 Jan 16.
    Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
    Clinical diagnosis of progressive supranuclear palsy (PSP) is sometimes difficult because various phenotypes have been identified. Here, we report a mutation in the bassoon (BSN) gene in a family with PSP-like syndrome. Their clinical features resembled not only those of PSP patients but also those of individuals with multiple system atrophy and Alzheimer's disease. Read More

    HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.
    Proc Natl Acad Sci U S A 2018 Jan 16. Epub 2018 Jan 16.
    Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY 10065;
    Mutations in CDCA7, the SNF2 family protein HELLS (LSH), or the DNA methyltransferase DNMT3b cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. While it has been speculated that DNA methylation defects cause this disease, little is known about the molecular function of CDCA7 and its functional relationship to HELLS and DNMT3b. Systematic analysis of how the cell cycle, H3K9 methylation, and the mitotic kinase Aurora B affect proteomic profiles of chromatin in Xenopus egg extracts revealed that HELLS and CDCA7 form a stoichiometric complex on chromatin, in a manner sensitive to Aurora B. Read More

    Neurologic disorders associated with anti-glutamic acid decarboxylase antibodies: A comparison of anti-GAD antibody titers and time-dependent changes between neurologic disease and type I diabetes mellitus.
    J Neuroimmunol 2018 Jan 9. Epub 2018 Jan 9.
    Department of Internal Medicine, Seikeikai Hospital, Sakai, Osaka 590-0064, Japan.
    To determine clinical features of neurologic disorders associated with anti-glutamic acid decarboxylase antibodies (anti-GAD-Ab), we examined titers and time-dependent changes of anti-GAD-Ab. Six patients, stiff person syndrome (2), cerebellar ataxia (1), limbic encephalitis (1), epilepsy (1), brainstem encephalitis (1), were compared with 87 type I diabetes mellitus (T1DM) patients without neurologic disorders. Anti-GAD-Ab titers and index were higher in neurologic disorders than in T1DM, suggesting intrathecal antibody synthesis. Read More

    Survival Benefit of Japanese Extended Lymphadenectomy for Clinically Node-Negative and Node-Positive Colorectal Cancers.
    Dis Colon Rectum 2018 Feb;61(2):162-171
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
    Background: The impact of extended lymphadenectomy for colorectal cancer is still not sufficiently clear.

    Objective: The aim of the present study was to evaluate the survival benefit of extended lymphadenectomy compared with nonextended lymphadenectomy for clinically node-negative and node-positive colorectal cancers.

    Design: The present study was a retrospective cohort study that used prospectively collected data and a propensity score matching method. Read More

    Serum Bilirubin Concentration is Associated with Left Ventricular Remodeling in Patients with Type 2 Diabetes Mellitus: A Cohort Study.
    Diabetes Ther 2018 Jan 15. Epub 2018 Jan 15.
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Introduction: Previous studies have shown that serum bilirubin concentration is inversely associated with the risk of cardiovascular disease. The relationship between serum bilirubin concentration and left ventricular geometry, however, has not been investigated in patients with diabetes mellitus.

    Methods: In this cohort study, 158 asymptomatic patients with type 2 diabetes mellitus without overt heart disease were enrolled. Read More

    The Childhood Arthritis & Rheumatology Research Alliance Consensus Treatment Plans: Towards Comparative Effectiveness in the Pediatric Rheumatic Diseases.
    Arthritis Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Pediatric Rheumatology, Hackensack University Medical Center, Hackensack, United States.
    The pediatric rheumatic diseases are a heterogeneous group of rare diseases, posing a number of challenges for the use of traditional clinical and translational research approaches. Innovative comparative effectiveness approaches are needed to efficiently study treatment approaches and disease outcomes. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed the consensus treatment plan (CTP) approach as a comparative effectiveness tool for research in pediatric rheumatology. Read More

    Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases.
    Neurosci Lett 2018 Jan 9;668:43-47. Epub 2018 Jan 9.
    Laboratory of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan. Electronic address:
    Evaluation of transmission properties is important for the differential diagnosis of a subgroup of acquired Creutzfeldt-Jakob disease (CJD) with methionine homozygosity at polymorphic codon 129 of the PRNP gene, an intermediate type abnormal prion protein (PrP), and kuru plaques, denoted as acquired CJD-MMiK. The present study aimed to develop a quick evaluation system of the transmission properties of acquired CJD-MMiK. In the PrP-humanized mice intraperitoneally inoculated with brain homogenates from an acquired CJD-MMiK patient, accumulation of abnormal PrP was observed in follicular dendritic cells of the spleen at 75 days post-inoculation. Read More

    Prevalence of diabetes mellitus in individuals with airflow obstruction in a Japanese general population: The Yamagata-Takahata Study.
    Respir Investig 2018 Jan 7;56(1):34-39. Epub 2017 Dec 7.
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. Electronic address:
    Background: Diabetes has been reported as a comorbidity of chronic obstructive pulmonary disease (COPD) in Western countries, but it has not been demonstrated in epidemiological reports in Japan. The purpose of this study was to clarify whether the relationship between airflow obstruction and diabetes can be confirmed in a Japanese general population.

    Methods: From 2004 to 2006, blood sampling and pulmonary function tests were performed on 3045 people over the age of 40 years in annual health check-ups held in Takahata, Yamagata Prefecture, Japan. Read More

    A Clinicopathological Analysis of Six Autopsy Cases of Sudden Unexpected Death Due to Infectious Aortitis in Patients with Aortic Tears.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Japan.
    Objectives Cardiovascular disease is a leading cause of sudden unexpected death even in hospitalized patients. Infectious aortitis is a rare disease that has the potential to cause aortic tears and hemorrhage followed by sudden death. The aim of this study was to reveal the clinicopathological features of infectious aortitis that are related to sudden unexpected death. Read More

    Safety and efficacy of sofosbuvir and ribavirin for genotype 2 hepatitis C Japanese patients with renal dysfunction.
    Hepatol Res 2018 Jan 9. Epub 2018 Jan 9.
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
    Background And Aim: The safety and efficacy of sofosbuvir and ribavirin have not been well clarified in patients with renal dysfunction because clinical trials did not include such patients. We evaluated the safety and efficacy of sofosbuvir and ribavirin for genotype 2 hepatitis C virus (HCV)-infected patients with renal dysfunction.

    Methods: The study included genotype 2 HCV-infected patients who received sofosbuvir and ribavirin between July 2014 and May 2017. Read More

    Activities concentration of radiocesium in wild mushroom collected in Ukraine 30 years after the Chernobyl power plant accident.
    PeerJ 2018 5;6:e4222. Epub 2018 Jan 5.
    Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
    Mushrooms are recognized as one of the main contributors to internal radiation exposure from the activity concentration of radiocesium released by the accident at the Chernobyl nuclear power plant (CNNP). We evaluated the activity concentrations of the artificial radionuclides (radiocesium) in wild mushrooms collected in 2015 from Korosten and Lugine, Zhitomir region, Ukraine, located 120 km away from the CNPP. Cesium-137 was detected in 110 of 127 mushroom samples (86. Read More

    Kimura disease of buccal region in a pediatric patient with nephrotic syndrome: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8990
    Department of Otolaryngology-Head and Neck Surgery.
    Rationale: Kimura disease is a rare benign, chronic inflammatory disorder that typically presents with slowly enlarging, nontender, subcutaneous swellings in the head and neck region. The occurrence of Kimura disease in the oral cavity is extremely rare.

    Patient Concerns: A 16-year-old boy presented with a complaint of a right painless buccal mass of 3 years' duration. Read More

    Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma.
    Cancer Lett 2018 Jan 3;417:168-173. Epub 2018 Jan 3.
    AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USA. Electronic address:
    We have previously established a patient-derived orthotopic xenograft (PDOX) model of undifferentiated spindle cell sarcoma (USCS). Recombinant methioninase (rMETase) has previously demonstrated efficacy in PDOX mouse models of human cancers. In the present study, we determined if rMETase in combination with doxorubicin (DOX) can overcome first-line DOX resistance in a PDOX models of USCS. Read More

    IRF-2 haploinsufficiency causes enhanced imiquimod-induced psoriasis-like skin inflammation.
    J Dermatol Sci 2017 Dec 28. Epub 2017 Dec 28.
    Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
    Backgrounds: IFN regulatory factor (IRF)-2 is one of the potential susceptibility genes for psoriasis, but how this gene influences psoriasis pathogenesis is unclear. Topical application of imiquimod (IMQ), a TLR7 ligand, induces psoriasis-like skin lesions in mice.

    Objective: The aim of this study was to investigate whether IRF-2 gene status would influence severity of skin disease in IMQ-treated mice. Read More

    Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis.
    Nat Commun 2018 01 2;9(1):17. Epub 2018 Jan 2.
    Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
    Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system. Foxp3+ regulatory T (Treg) cells are reduced in frequency and dysfunctional in patients with MS, but the underlying mechanisms of this deficiency are unclear. Here, we show that induction of human IFN-γ-IL-17A-Foxp3+CD4+ T cells is inhibited in the presence of circulating exosomes from patients with MS. Read More

    Complete remission of hypertension in a hemodialysis patient after adrenalectomy for primary aldosteronism and renal transplantation.
    CEN Case Rep 2017 Dec 29. Epub 2017 Dec 29.
    Department of Endocrinology and Hypertension, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
    A 64-year-old man was admitted to our hospital for the hormonal evaluation of a right adrenal adenoma. He had been diagnosed with severe proteinuria and hypertension, and antihypertensive treatment was started at the age of 60. His renal function gradually declined, and hemodialysis was begun at the age of 64. Read More

    High levels of DEK autoantibodies in sera of polyarticular JIA patients and in early flare following cessation of anti-TNF therapy.
    Arthritis Rheumatol 2017 Dec 29. Epub 2017 Dec 29.
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI.
    Objective: The nuclear oncoprotein DEK is an autoantigen associated with juvenile idiopathic arthritis (JIA), especially the oligoarticular subtype. DEK is a secreted chemoatactic factor. Abundant DEK and DEK autoantibodies are found in the inflamed JIA synovium. Read More

    Dembo-PCR technique for the detection of bovine abortion, diarrhea, and respiratory disease complex infectious agents in potential vectors and reservoirs.
    J Vet Sci 2017 Dec 28. Epub 2017 Dec 28.
    Research and Education Center for Prevention of Global Infectious Diseases of Animals, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 183-0045 Tokyo, Japan.
    The bovine abortion, diarrhea, and respiratory disease complexes, caused by infectious agents, result in high and significant economic losses for the cattle industry. These pathogens are likely transmitted by various vectors and reservoirs including insects, birds and rodents. However, experimental data that supports this possibility are scarce. Read More

    Characteristics of patients with atrial fibrillation prescribed antiplatelet monotherapy compared with those on anticoagulants: insights from the GARFIELD-AF registry.
    Eur Heart J 2017 Dec 20. Epub 2017 Dec 20.
    Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK.
    Aims: Current atrial fibrillation (AF) guidelines discourage antiplatelet (AP) monotherapy as alternative to anticoagulants (ACs). Why AP only is still used is largely unknown.

    Methods And Results: Factors associated with AP monotherapy prescription were analysed in GARFIELD-AF, a registry of patients with newly diagnosed (≤6 weeks) AF and ≥1 investigator-determined stroke risk factor. Read More

    A Case of Recurrent Ischemic Stroke due to Intravascular Lymphomatosis, Undiagnosed by Random Skin Biopsy and Brain Imaging.
    Case Rep Neurol 2017 Sep-Dec;9(3):234-240. Epub 2017 Oct 16.
    Department of Cerebrovascular Medicine, Stroke Center, Steel Memorial Yawata Hospital, Kitakyushu, Japan.
    Intravascular lymphoma (IVL) is a rare disease characterized by the proliferation of lymphoma cells in the lumen of the small blood vessels. Although early diagnosis of IVL is important to prolong survival of the patients, its atypical symptoms and clinical course often delay its diagnosis. More than half of the patients are diagnosed at autopsy. Read More

    A Case of Thyroid Papillary Carcinoma: Remarkable Decrease in Multiple Lung Metastases within 40 Years after a Single Administration of Radioiodine without Thyroidectomy and with Later Anaplastic Transformation.
    Case Rep Oncol 2017 Sep-Dec;10(3):928-937. Epub 2017 Oct 17.
    Department of Radiology, Graduate School of Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Differentiated thyroid carcinoma is an uncommon malignancy of childhood and adolescence that is unique because it has an overall favorable prognosis despite its relatively high rate of nodal and distant metastases. Total thyroidectomy and positive 131I therapy are recommended for cases with pulmonary metastases. In contrast, anaplastic thyroid cancer is one of the most aggressive malignancies that have an unfavorable and miserable prognosis. Read More

    Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients.
    J Clin Exp Hematop 2017 ;57(3):147-152
    Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Hospital and Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences.
    A 42-year-old man with eosinophilia and high serum immunoglobulin E (IgE) developed a lacrimal gland mass on the left side. Excisional biopsy revealed hyperplasia of lymphoid follicles, and infiltration with lymphocytes and eosinophils around lacrimal gland acini, leading to the pathological diagnosis of Kimura disease. IgE-positive cells were mainly found along follicular dendritic cells, and a small number of IgG4-positive cells was present. Read More

    Drug-induced Pressure Ulcers in a Middle-aged Patient with Early-stage Parkinson's Disease.
    Intern Med 2017 Dec 27. Epub 2017 Dec 27.
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Japan.
    Drug-induced pressure ulcer (DIPU), which is a newly recognized adverse drug reaction, is associated with the administration of psychiatric drugs in geriatric patients with dementia. The notification of the causative drugs is crucial to the treatment of DIPU. We herein report the case of a 56-year-old woman with early-stage Parkinson's disease who developed DIPUs after starting olanzapine treatment for depressive symptoms. Read More

    MR findings in the substantia nigra on phase difference enhanced imaging in neurodegenerative parkinsonism.
    Parkinsonism Relat Disord 2017 Dec 21. Epub 2017 Dec 21.
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Introduction: In Parkinson's disease (PD) patients, magnetic resonance (MR) imaging studies using phase difference enhanced imaging (PADRE) and susceptibility-weighted imaging (SWI) showed the obscuration of the boundary between the crural fibers and substantia nigra, and the absence of dorsolateral nigral hyperintensity, respectively. PADRE images have not been evaluated in other types of neurodegenerative parkinsonism, and PADRE and SWI images have not been compared. Here we evaluated PADRE and SWI images in patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), or PD and controls, and we compared the diagnostic values. Read More

    High Ionized Calcium Concentration Is Associated With Prolonged Length of Stay in the Intensive Care Unit for Postoperative Pediatric Cardiac Patients.
    J Cardiothorac Vasc Anesth 2017 Nov 8. Epub 2017 Nov 8.
    Department of Anesthesiology and Resuscitation, Okayama University Hospital, Okayama, Japan.
    Objective: There has been controversy regarding the beneficial effects of calcium on myocardial contractility and the harmful effects on myocardial cells, especially in children. The aim of this study was to investigate an association between ionized calcium concentration (iCa) and outcomes for pediatric patients after cardiac surgery.

    Design: A retrospective, single-center study from May 2013 to December 2014. Read More

    Peritoneal Dialysis and Retroperitoneal Laparoscopic Radical Nephrectomy: A Favorable Experience With a Patient Complicated by Renal Cell Carcinoma.
    Clin Med Insights Case Rep 2017 10;10:1179547617746362. Epub 2017 Dec 10.
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke-Shi, Japan.
    Peritoneal dialysis (PD) is an accepted modality for managing end-stage kidney disease. We herein report a 75-year-old female patient on chronic PD who was complicated by renal cell carcinoma. She was successfully treated with retroperitoneal laparoscopic radical nephrectomy followed by a prompt resumption of the procedure. Read More

    Multiple Eruptive Epithelioid Hemangiomas: A Subset of Cutaneous Cellular Epithelioid Hemangioma With Expression of FOS-B.
    Am J Surg Pathol 2017 Dec 20. Epub 2017 Dec 20.
    Dermatopathology Department, Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
    There is a wide clinicopathologic spectrum of vascular proliferations characterized by the presence of epithelioid endothelial cells, comprising epithelioid hemangioma (EH)-pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma (PM-HAE), epithelioid hemangioendothelioma, and epithelioid angiosarcoma. Immunohistochemical FOS-B expression as well as FOS-B rearrangement (fluorescent in situ hybridization [FISH]) have recently been described as diagnostically relevant underpinnings of EH (restricted to osseous lesions) and PM-HAE. The aim of this study was to clinicopathologically characterize and to elucidate FOS-B expression in patients with eruptive lesions of the cellular variant of cutaneous EH. Read More

    A structural MRI study of cholinergic pathways and cognition in multiple sclerosis.
    eNeurologicalSci 2017 Sep 1;8:11-16. Epub 2017 Jul 1.
    Department of Radiology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
    Background: White matter hyperintensities (WMH) in the cholinergic pathways are associated with cognitive performance in Alzheimer's disease. This study aimed to evaluate the relationship between the volume reduction of cholinergic pathways and cognitive function in patients with multiple sclerosis (MS).

    Methods: Thirty-two MS patients underwent a brain MRI and cognitive measurements including the Mini-Mental State Examination (MMSE) and the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Read More

    Does cerebral large-artery disease contribute to cognitive impairment?
    eNeurologicalSci 2017 Sep 13;8:5-8. Epub 2017 Jun 13.
    Department of Neurology, Fukuoka University, Fukuoka, Japan.
    Purpose: Although many patients with cerebral large-artery disease (CLAD) show impaired cognitive performance, the risk factors remain unclear in this population. The objective of this study was to evaluate cognitive impairment and its risk factors in patients with CLAD.

    Methods: We recruited non-demented patients with CLAD from our hospital. Read More

    Cell transfer technology for tissue engineering.
    Inflamm Regen 2017 16;37:21. Epub 2017 Oct 16.
    Department of Cellular Physiological Chemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510 Japan.
    We recently developed novel cell transplantation method "cell transfer technology" utilizing photolithography. Using this method, we can transfer ex vivo expanded cells onto scaffold material in desired patterns, like printing of pictures and letters on a paper. We have investigated the possibility of this novel method for cell-based therapy using several disease models. Read More

    Molecular Evolution of the VP1 Gene in Human Norovirus GII.4 Variants in 1974-2015.
    Front Microbiol 2017 5;8:2399. Epub 2017 Dec 5.
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Musashimurayama, Japan.
    Human norovirus (HuNoV) is a leading cause of viral gastroenteritis worldwide, of which GII.4 is the most predominant genotype. Unlike other genotypes, GII. Read More

    Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle.
    Sci Rep 2017 Dec 19;7(1):17827. Epub 2017 Dec 19.
    Institute of Agrobiological Sciences, NARO, Ikenodai 2, Tsukuba, Ibaraki, 305-8602, Japan.
    Isoleucyl-tRNA synthetase (IARS) syndrome is a recessive disease of Japanese Black cattle caused by a single nucleotide substitution. To repair the mutated IARS gene, we designed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) to create a double-strand break near the mutation site. CRISPR/Cas9 and donor DNA that contained a synonymous codon for the correct amino acid and an Aequorea coerulescens Green Fluorescent Protein (AcGFP) cassette with a piggyBac transposase recognition site at both ends were introduced into bovine fetal fibroblast (BFF) cells isolated from a homozygous mutant calf. Read More

    Utility of Magnetic Resonance Enterography For Small Bowel Endoscopic Healing in Patients With Crohn's Disease.
    Am J Gastroenterol 2017 Dec 19. Epub 2017 Dec 19.
    Department of Gastroenterology and Hepatology, Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
    Objectives: Small bowel (SB) endoscopic healing has not been well studied in patients with Crohn's disease (CD). This study aims to evaluate the utility of magnetic resonance (MR) enterography (MRE) for SB lesions in comparison with balloon-assisted enteroscopy (BAE) findings.

    Methods: In total, 139 patients with CD in clinical-serological remission were prospectively followed after BAE and MRE procedures. Read More

    Mucosal-Associated Invariant T Cells in Regenerative Medicine.
    Front Immunol 2017 1;8:1711. Epub 2017 Dec 1.
    Office of Regulatory Science, Pharmaceutical and Medical Device Agency (PMDA), Tokyo, Japan.
    Although antibiotics to inhibit bacterial growth and small compounds to interfere with the productive life cycle of human immunodeficiency virus (HIV) have successfully been used to control HIV infection, the recent emergence of the drug-resistant bacteria and viruses poses a serious concern for worldwide public health. Despite intensive scrutiny in developing novel antibiotics and drugs to overcome these problems, there is a dilemma such that once novel antibiotics are launched in markets, sooner or later antibiotic-resistant strains emerge. Thus, it is imperative to develop novel methods to avoid this vicious circle. Read More

    Stroke-associated infection independently predicts 3-month poor functional outcome and mortality.
    J Neurol 2017 Dec 16. Epub 2017 Dec 16.
    Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
    Stroke-associated infection (SAI) is a common and serious complication of stroke. This study aimed to assess the effects of SAI on patient mortality and functional outcome at 3 months after stroke onset. We retrospectively analyzed 809 consecutive patients with acute stroke (517 men and 292 women; median age, 72 years) who were admitted to our department between September 2014 and June 2016. Read More

    Ameliorative effect of panaxynol on the reduction in high-molecular-weight adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acids.
    Eur J Pharmacol 2018 Feb 14;820:138-145. Epub 2017 Dec 14.
    Laboratory of Natural Resources, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan. Electronic address:
    Reduced plasma levels of the high-molecular weight (HMW) form of adiponectin, rather than total adiponectin levels, have been shown to be closely associated with various metabolic diseases including insulin resistance, type 2 diabetes, and cardiovascular disease. Therefore, we sought to explore active, naturally occurring compounds that promote the recovery of HMW adiponectin secretion suppressed by palmitic acid in our model. A total of 90 crude drug extracts were screened for the ability to augment HMW adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acid. Read More

    Frequency of Fruit and Vegetable Consumption and the Oral Health-Related Quality of Life among Japanese Elderly: A Cross-Sectional Study from the Kyoto-Kameoka Study.
    Nutrients 2017 Dec 15;9(12). Epub 2017 Dec 15.
    Department of Health and Sports Sciences, Kyoto Gakuen University, Kyoto 621-8555, Japan.
    Objective: Many previous studies have reported that fruit and vegetable consumption is associated with a reduced risk of various disease, but whether or not their consumption is associated with the oral health-related quality of life (OHRQoL) is unclear. The objective of this study was to examine the association between the frequency of fruit and vegetable consumption and the OHRQoL in elderly subjects by sex.

    Methods: We analyzed cross-sectional data from a population-based Kyoto-Kameoka Study in 2012 of 3112 men and 3439 women (age ≥ 65 years). Read More

    A distinct subtype of Epstein Barr virus positive T/NK-cell lymphoproliferative disorder: Adult patients with chronic active Epstein Barr virus infection-like features.
    Haematologica 2017 Dec 14. Epub 2017 Dec 14.
    Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
    The characteristics of adult patients with chronic active Epstein-Barr virus infection (adult-onset CAEBV) are poorly recognized, hindering early diagnosis and an improved prognosis. Adult-onset CAEBV (n = 54) diagnosed between 2005 and 2015 were conducted. Adult-onset was defined as an estimated age of onset ≥15 years. Read More

    Short Leukocyte Telomere Length Precedes Clinical Expression of Atherosclerosis: Blood-and-Muscle Model.
    Circ Res 2017 Dec 14. Epub 2017 Dec 14.
    Center of Human Development and Aging, Rutgers, The State University of New Jersey.
    Rationale:  Short telomere length (TL) in leukocytes is associated with atherosclerotic cardiovascular disease (ASCVD). It is unknown whether this relationship stems from having inherently short leukocyte TL (LTL) at birth and/or a faster LTL attrition thereafter. LTL represents TL in the highly proliferative hematopoietic system, while TL in skeletal muscle (M) represents a minimally replicative tissue. Read More

    Kimura Disease: A Rare Case Report From Himalayan Region.
    Indian J Otolaryngol Head Neck Surg 2017 Dec 5;69(4):571-574. Epub 2017 Jan 5.
    Department of Otolaryngology and HNS (ENT), AIIMS, Virbhadra Marg, Rishikesh, Uttarakhand 240201 India.
    Kimura's disease is a rare disorder of uncertain aetiology seen in Asian population, and presents as painless lymphadenopathy or subcutaneous masses in head-neck region. Peripheral eosinophilia, elevated levels of serum IgE, lymphoid proliferation and eosinophilic infiltration are its characteristic pathological features. We report a case of 40 year old male patient who presented with swelling behind right ear after successful ear surgery. Read More

    Clinical and magnetic resonance imaging features of elderly onset dentatorubral-pallidoluysian atrophy.
    J Neurol 2017 Dec 13. Epub 2017 Dec 13.
    Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
    Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant spinocerebellar ataxia caused by CAG triplet expansion in atrophin 1 and is frequently associated with cerebral white matter lesions. To elucidate the clinical features of elderly onset DRPLA and the key radiological findings for differentiating DRPLA from physiological white matter lesions in healthy elderly subjects, we reviewed the clinical and magnetic resonance imaging (MRI) features of ten patients with elderly onset genetically confirmed DRPLA (> 60 years) and compared their MRI findings with those of age- and sex-matched ten healthy subjects with asymptomatic cerebral white matter lesions. The initial symptom was cerebellar ataxia in all DRPLA patients, and five of them did not have any symptoms other than ataxia at the time of MRI examination. Read More

    Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey in Japan.
    J Pediatr 2017 Dec 7. Epub 2017 Dec 7.
    Japan Society of Kawasaki Disease, Tokyo, Japan.
    Objective: To assess the safety and efficacy of infliximab (IFX) for the treatment of patients with Kawasaki disease (KD).

    Study Design: This was a nationwide survey of 274 Japanese institutions exploring how IFX was used to treat patients with KD. The patients' sex, age, treatment course, pre- and post-IFX therapy blood test results, coronary artery lesions (CALs), and adverse events (AEs) were evaluated. Read More

    Validation and reliability of the Timed Up and Go test for measuring objective functional impairment in patients with long-standing rheumatoid arthritis: a cross-sectional study.
    Int J Rheum Dis 2017 Dec 5. Epub 2017 Dec 5.
    Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan.
    Aim: This study aimed to validate the Timed Up and Go test (TUG) for measuring objective functional impairment in patients with established rheumatoid arthritis (RA) based on a prospective observational cohort of RA patients undergoing joint surgery.

    Methods: We collected data on demographics, Health Assessment Questionnaire Disability Index (HAQ-DI), and associations between TUG and HAQ-DI and other patient-reported outcomes, including European Quality of life scale (EQ-5D) were determined. Cut-off values of TUG for HAQ remission (HAQ-DI ≤0. Read More

    Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.
    J Biol Chem 2017 Dec 1. Epub 2017 Dec 1.
    Tokyo Metropolitan University, Japan;
    Tau is a microtubule (MT)-associated protein that regulates MT dynamics in the axons of neurons. Tau binds to MTs via its C-terminal MT-binding repeats. There are two types of tau, those with 3 (3R) or 4 (4R) MT-binding repeats; 4R tau has a stronger MT-stabilizing activity than 3R tau. Read More

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