19,043 results match your criteria Kikuchi Disease


Full-genome analysis of hepatitis C virus in Japanese and non-Japanese patients coinfected with HIV-1 in Tokyo.

J Acquir Immune Defic Syndr 2018 Dec 6. Epub 2018 Dec 6.

AIDS Clinical Center and.

Background: Acute hepatitis C virus (HCV) infection is increasing among HIV-1-infected individuals in Tokyo. Appropriate clinical management is needed.

Setting: To delineate the epidemiological status of HCV transmission, we analyzed stocked plasma samples of HCV/HIV-1-coinfected patients seen at the largest referral center for HIV care in Tokyo. Read More

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December 2018

Effects of body position during cardiopulmonary exercise testing with right heart catheterization.

Physiol Rep 2018 Dec;6(23):e13945

Division of Cardiology, Department of Medicine, Kyorin University Hospital, Mitaka, Tokyo, Japan.

Cardiopulmonary exercise testing (CPX) with right heart catheterization (RHC) widely used for early diagnosis and evaluation of pulmonary vascular disease in patients with pulmonary arterial hypertension and early stage heart failure with preserved ejection fraction, who display normal hemodynamics at rest. The aim of this study was to investigate that whether body position affects pulmonary hemodynamics, pulmonary arterial wedge pressure (PAWP), and CPX parameters during invasive CPX. Seventeen patients (58 ± 14 years; 5/12 male/female) with chronic thromboembolic pulmonary hypertension treated with percutaneous transluminal pulmonary angioplasty and near-normal pulmonary artery pressure (PAP) underwent invasive CPX twice in supine and upright position using a cycle ergometer with 6 months interval. Read More

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December 2018
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Combination therapy with corticosteroid and mycophenolate mofetil in a case of refractory cardiac sarcoidosis.

J Cardiol Cases 2016 Apr 6;13(4):125-128. Epub 2016 Mar 6.

Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.

Management of cardiac sarcoidosis (CS) can be challenging. The first-line therapy for this condition is corticosteroids, but other immunosuppressive agents are sometimes co-administered to reduce the dosage of corticosteroid and to thereby avoid steroid-induced adverse effects or to increase its therapeutic efficacy. Mycophenolate mofetil (MMF) is a prodrug of mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase that acts more selectively on T and B lymphocytes when compared with azathioprine. Read More

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Clinical usefulness of gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography with phase analysis for the management of patients with isolated ventricular noncompaction.

J Cardiol Cases 2015 Apr 24;11(4):101-104. Epub 2014 Dec 24.

Department of Cardiovascular Medicine, Nippon Medical School Hospital, Tokyo, Japan.

Gated Tc-99m sestamibi myocardial perfusion single-photon emission computed tomography (GMPS) with phase analysis provides information on myocardial perfusion, left ventricular (LV) function, and LV dyssynchrony. We present a case of isolated left ventricular noncompaction (IVNC) cardiomyopathy in which GMPS with phase analysis proved to be beneficial and reliable to monitor the long-term response to cardiac resynchronization therapy with defibrillator (CRT-D). The patient was an 84-year-old man with shortness of breath on minimal exertion (New York Heart Association class III) who had severe drug-refractory heart failure with hypotension and ventricular tachycardia. Read More

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Evaluation of prostate-specific antigen density in the diagnosis of prostate cancer combined with magnetic resonance imaging before biopsy in men aged 70 years and older with elevated PSA.

Mol Clin Oncol 2018 Dec 19;9(6):656-660. Epub 2018 Sep 19.

Department of Urology, Keio University School of Medicine, Tokyo 160-8582, Japan.

There is an increasing proportion of individuals aged 70 years and older, as well as an increasing life expectancy worldwide. The present study may guide the management of older patients with elevated prostate specific antigen (PSA). The medical records of 241 older men aged >70 years who underwent multiparametric magnetic resonance imaging (mpMRI) before prostate biopsy (PBx) at our institution were reviewed retrospectively. Read More

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December 2018

Immunoglobulin G4-Related Disease Arising from the Bladder Wall.

Urol Int 2018 Dec 13:1-3. Epub 2018 Dec 13.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a recently described inflammatory disease with multiorgan involvement. Although there were reports of IgG4-related kidney disease or prostatitis, this disease rarely presents in the bladder. In this report, we describe a case of IgG4-RD arising from bladder wall. Read More

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December 2018

Exploratory machine-learned theoretical chemical shifts can closely predict metabolic mixture signals.

Chem Sci 2018 Nov 10;9(43):8213-8220. Epub 2018 Sep 10.

RIKEN Center for Sustainable Resource Science , 1-7-22 Suehiro-cho, Tsurumi-ku , Yokohama , Kanagawa 230-0045 , Japan . Email:

Various chemical shift predictive methodologies have been studied and developed, but there remains the problem of prediction accuracy. Assigning the NMR signals of metabolic mixtures requires high predictive performance owing to the complexity of the signals. Here we propose a new predictive tool that combines quantum chemistry and machine learning. Read More

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November 2018

[Descriptive epidemiology of accelerometer-measured moderate to vigorous physical activity in Japanese older adults].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):584-593

Department of Preventive Medicine and Public Health, Tokyo Medical University.

Aim: Most physical activity (PA) guidelines for health promotion recommend moderate to vigorous PA (MVPA) lasting at least 10 minutes (long-bout MVPA). However, recent studies have shown the beneficial effects of short-bout MVPA (intermittent and lasting <10 minutes). Therefore, we aimed to clarify the detailed patterns of MVPA of community-dwelling older adults using accelerometers. Read More

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January 2018

A novel, flexible and automated manufacturing facility for cell-based health care products: Tissue Factory.

Regen Ther 2018 Dec 19;9:89-99. Epub 2018 Sep 19.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Introduction: Current production facilities for Cell-Based Health care Products (CBHPs), also referred as Advanced-Therapy Medicinal Products or Regenerative Medicine Products, are still dependent on manual work performed by skilled workers. A more robust, safer and efficient manufacturing system will be necessary to meet the expected expansion of this industrial field in the future. Thus, the 'flexible Modular Platform (fMP)' was newly designed to be a true "factory" utilizing the state-of-the-art technology to replace conventional "laboratory-like" manufacturing methods. Read More

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December 2018

Embryo production by intracytoplasmic injection of sperm retrieved from Meishan neonatal testicular tissue cryopreserved and grafted into nude mice.

Anim Sci J 2018 Dec 6. Epub 2018 Dec 6.

Institute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan.

Testicular xenografting, combined with cryopreservation can assist conservation of the genetic diversity of indigenous pigs by salvaging germ cells from their neonatal testes. Using Meishan male piglets as an example, we examined whether testicular tissue would acquire the ability to produce sperm after cryopreservation and grafting into nude mice (MS group). For comparison, testicular tissue from neonatal Western crossbreed male piglets was used (WC group). Read More

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December 2018

A novel c.166A>T (p.Thr56Ser) mutation in GYPB*S accounting for unusual S antigen expression.

Vox Sang 2018 Dec 6. Epub 2018 Dec 6.

Japanese Red Cross Central Blood Institute, Tokyo, Japan.

We found an individual with weakened S antigen expression on red blood cells (RBCs) during routine blood grouping. The proband was typed S+s+ by polyclonal antibodies, but the RBCs demonstrated different reactivity with three monoclonal anti-S. The proband did not have alloanti-S. Read More

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December 2018

Visualization of carotid vessel wall and atherosclerotic plaque: T1-SPACE vs. compressed sensing T1-SPACE.

Eur Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Objectives: To compare visualization of carotid plaques and vessel walls between 3D T1-fast spin echo imaging with conventional SPACE (T1-SPACE) and with a prototype compressed sensing T1-SPACE (CS-T1-SPACE) METHODS: This retrospective study was approved by the institutional review board. Participants comprised 43 patients (36 males, 7 females; mean age, 71 years) who underwent carotid MRI including T1-SPACE and CS-T1-SPACE. The quality of visualization for carotid plaques and vessel walls was evaluated using a 5-point scale, and signal intensity ratios (SRs) of the carotid plaques were measured and normalized to the adjacent sternomastoid muscle. Read More

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December 2018

Improving overall health of children living with HIV through an oral health intervention in Cambodia: study protocol for a randomized controlled trial.

Trials 2018 Dec 6;19(1):673. Epub 2018 Dec 6.

KHANA Center for Population Health Research, Phnom Penh, Cambodia.

Background: Currently, the number of children living with HIV is the highest ever. This has led to an increased focus on a healthy life expectancy in this population. Improving oral health status may contribute to improved immunity, which could in turn lead to greater overall health in this population. Read More

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December 2018

Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.

Digestion 2018 Dec 12:1-10. Epub 2018 Dec 12.

Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Background/aims: Behçet's disease (BD) with intestinal lesions and Crohn's disease (CD) share clinical features. However, no report has compared the 2 diseases with regard to lesions of the upper gastrointestinal tract (UGT). We aimed to evaluate endoscopic and histologic findings of UGT in CD and BD. Read More

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December 2018

Brief Report: A Novel System to Evaluate Autism Spectrum Disorders Using Two Humanoid Robots.

J Autism Dev Disord 2018 Dec 11. Epub 2018 Dec 11.

Research Center for Child Mental Development, Kanazawa University, 13-1, Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.

We investigated the feasibility of our novel evaluation system for use with children with autism spectrum disorders (ASD). We prepared the experimental setting with two humanoid robots in reference to the birthday party scene in the Autism Diagnostic Observational Schedule (ADOS). We assessed the relationship between social communication ability measured in the ADOS condition (i. Read More

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December 2018
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Expression of VEGF in human conjunctival melanoma analyzed with immunohistochemistry.

Clin Ophthalmol 2018 19;12:2363-2367. Epub 2018 Nov 19.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan,

Purpose: The aim of this study was to examine the immunolocalization of VEGF-A and CD34, a marker of endothelial cells, in human conjunctival melanoma.

Methods: This study retrospectively analyzed primary conjunctival melanoma patients who underwent surgical resection of the tumor. All excised tissues were fixed with paraformaldehyde and embedded in paraffin, which were then submitted for immunohistochemistry with anti-VEGF and CD34 antibodies. Read More

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November 2018

The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer.

J Exp Clin Cancer Res 2018 Dec 11;37(1):307. Epub 2018 Dec 11.

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: The peritoneum is one of the most frequent metastatic sites in pancreatic cancer patients, and peritoneal dissemination makes this disease refractory due to aggressive progression and chemoresistance. Although the role of the tumor microenvironment in cancer development is recognized, the correlation between the peritoneal environment and refractoriness of peritoneal dissemination remains unclear. The intraperitoneal tumor-microenvironment and its potential role in the progression of peritoneal dissemination and chemo-refractoriness, focusing especially on macrophages, were investigated. Read More

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December 2018

Switching to tacrolimus extended-release improved the effectiveness of immunosuppressive therapy in a heart transplant patient: A case report.

J Cardiol Cases 2012 Jul 14;6(1):e26-e29. Epub 2012 May 14.

Tokyo Women's Medical University Medical Center East, Tokyo, Japan.

We report on a 25-year-old female heart transplant patient who presented with recurrent episodes of cellular rejection due to decreased adherence to immunosuppressive therapy. She received a heart transplantation in 1994 when she was 10 years old. In order to improve her adherence to immunosuppressive therapy, switching to the once-daily extended-release formulation of tacrolimus was performed in a step-wise fashion. Read More

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Complete Genome Sequence of Streptococcus agalactiae Serotype III, Multilocus Sequence Type 335 Strain HU-GS5823, Isolated from a Human Patient in Japan with Severe Invasive Infection.

Microbiol Resour Announc 2018 Nov 21;7(20). Epub 2018 Nov 21.

Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Streptococcus agalactiae is an important causal pathogen of neonatal and obstetric sepsis, and it may be involved in invasive infection in immunocompromised and elderly individuals. Here, we report the complete genome sequence of Streptococcus agalactiae serotype III strain HU-GS5823, which was isolated from a patient in Japan with an invasive infection. Read More

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November 2018

Chromatin accessibility identifies diversity in mesenchymal stem cells from different tissue origins.

Sci Rep 2018 Dec 10;8(1):17765. Epub 2018 Dec 10.

Department of Stem Cell Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Mesenchymal stem cells (MSCs), which can differentiate into tri-lineage (osteoblast, adipocyte, and chondrocyte) and suppress inflammation, are promising tools for regenerative medicine. MSCs are phenotypically diverse based on their tissue origins. However, the mechanisms underlying cell-type-specific gene expression patterns are not fully understood due to the lack of suitable strategy to identify the diversity. Read More

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December 2018

[Thrombotic microangiopathy developing subsequent to tocilizumab therapy in a patient with TAFRO syndrome].

Rinsho Ketsueki 2018 ;59(11):2432-2437

Department of Pathology, Hakodate Municipal Hospital.

We report a case of a 60-year-old male who presented with fever and anasarca as well as hepatosplenomegaly, general lymphadenopathy, and disseminated intravascular coagulation (DIC), and was, therefore, admitted to our hospital. In addition, the patient suffered from respiratory failure and renal dysfunction and had pleural effusion and ascites. The pathological diagnosis from lymph node biopsy suggested multicentric Castleman's disease of the plasma cell type; however, the presence of high IL-6 levels, myelofibrosis, thrombocytopenia, anasarca, renal dysfunction, and hepatosplenomegaly led to a definitive diagnosis of TAFRO syndrome. Read More

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January 2018

Fucoxanthin potentiates anoikis in colon mucosa and prevents carcinogenesis in AOM/DSS model mice.

J Nutr Biochem 2018 Oct 25;64:198-205. Epub 2018 Oct 25.

Epidemiology and Preventions Group, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Fucoxanthin (Fx) and its biotransformed fucoxanthinol (FxOH) present strong anti-cancer effects in vitro and in vivo, however, the underlying mechanisms are not well known. We recently demonstrated that FxOH could induce anoikis-like cells in human colorectal cancer (CRC) cells. Thus, we developed molecular hallmarks for anoikis in vitro, and to confirm induction of such molecular hallmarks in an azoxymethane/ dextran sodium sulfate carcinogenic model by Fx ingestion. Read More

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October 2018

Changes in functional connectivity dynamics with aging: A dynamical phase synchronization approach.

Neuroimage 2018 Dec 7. Epub 2018 Dec 7.

Research Center for Child Mental Development, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan; Department of Neuropsychiatry, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji, Yoshida, Fukui, 910-1193, Japan. Electronic address:

The dynamics of the human brain network has attracted broad attention, in recognition of the concept that functional connectivity is not static, but changes its pattern over time, even in the resting state. We hypothesized that analysis of continuously captured time-varying instantaneous phase synchronization between signals from different brain regions might add another dimension to already identified network dynamics. To validate this hypothesis as an aid to elucidating the physiological mechanisms of aging, we examined time-series of instantaneous phase synchronization events in resting-state EEG activity across the brain, in healthy younger and healthy older subjects. Read More

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December 2018

Myocardial Infarction Caused by Accelerated Plaque Formation Related to Myocardial Bridge in a Young Man.

Can J Cardiol 2018 Dec 20;34(12):1687.e13-1687.e15. Epub 2018 Aug 20.

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

A 28-year-old man without coronary risk factors was admitted to the hospital with acute coronary syndromes (ACS). The angiogram and intravascular ultrasound revealed myocardial bridge (MB) in the mid-left anterior descending artery and flow-limiting plaque located 15.4 mm proximal to MB. Read More

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December 2018

Effect of number of views on cross-sectional Compton imaging: A fundamental study with backprojection.

Phys Med 2018 Dec 15;56:1-9. Epub 2018 Nov 15.

Gunma University Heavy Ion Medical Center, Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma, Japan; Department of Radiation Oncology, Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma, Japan.

Introduction: We have been developing a medical imaging technique using a Compton camera, which is expected to reconstruct three-dimensional images. If the number of views is not sufficient, star-shaped artifacts (streak artifacts) could arise in cross-sectional images. Therefore, we estimated the point spread function (PSF) of cross-sectional Compton images and the effect of the number of views by Monte Carlo simulations and experimental studies. Read More

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December 2018

Carotid Endarterectomy for Medical Therapy-resistant Symptomatic Low-grade Stenosis.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: Plaque characteristics play pivotal roles in ischemic events, but stenosis severity does not accurately reflect carotid plaque volume due to expansive remodeling in some patients with low-grade stenosis (LGS).

Objective: This study aimed to assess the safety, efficacy, and durability of carotid endarterectomy (CEA) for symptomatic LGS.

Methods: Study participants comprised 61 consecutive patients who underwent CEA for symptomatic carotid stenosis. Read More

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December 2018
5 Reads

Two jatropha karyotypes constructed from meiotic pachytene chromosomes: Pericentric distribution of heterochromatin and variation in repetitive DNAs.

PLoS One 2018 6;13(12):e0208549. Epub 2018 Dec 6.

Department of Agronomy, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University, Kamphaeng Saen, Nakhon Pathom, Thailand.

Jatropha (Jatropha curcas) is an oil-bearing plant used for biodiesel production. Construction of its standard karyotype and identification of the euchromatin/heterochromatin distribution associated with gene expression and meiotic recombination are essential to fully characterize its genome. Here, we developed a J. Read More

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December 2018
1 Read
3.234 Impact Factor

Coexistence of systemic lupus erythematosus with Kikuchi-Fujimoto disease involving the salivary gland, initially disguised as lymphoma.

Rheumatology (Oxford) 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Department of Internal Medicine, Jeonju, Republic of Korea.

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December 2018
1 Read

Melanogenesis-Inhibitory and Cytotoxic Activities of Triterpene Glycoside Constituents from the Bark of Albizia procera.

J Nat Prod 2018 Dec 6. Epub 2018 Dec 6.

Department of Natural Medicine Chemistry, School of Traditional Chinese Pharmacy , China Pharmaceutical University , 24 Tongjiaxiang , Nanjing 210009 , People's Republic of China.

Five oleanane-type triterpene glycosides including three new ones, proceraosides E-G (1-3), were isolated from a MeOH-soluble extract of Albizia procera bark. The structures of 1-3 were determined by use of NMR spectra, HRESIMS, and chemical methods. Compounds 1-5 exhibited inhibitory activities against the proliferation of the A549, SKBR3, AZ521, and HL60 human cancer cell lines (IC 0. Read More

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December 2018
3 Reads

Prediction of folding mechanisms for Ig-like beta sandwich proteins based on inter-residue average distance statistics methods.

Proteins 2018 Dec 6. Epub 2018 Dec 6.

Department of Bioinformatics, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.

To understand the folding mechanism of a protein is one of the goals in bioinformatics study. Nowadays, it is enigmatic and difficult to extract folding information from amino acid sequence by using standard bioinformatics techniques or even experimental protocols which can be time consuming. To overcome these problems, we aim to extract the initial folding unit for titin protein (Ig and fnIII domains) by means of inter-residue average distance statistics, Average Distance Map (ADM) and contact frequency analysis (F-value). Read More

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December 2018
3 Reads

Magnetic, thermal, and neutron diffraction studies of a coordination polymer: bis(glycolato)cobalt(ii).

Dalton Trans 2018 Dec 6. Epub 2018 Dec 6.

General Education, Faculty of Science and Technology, Seikei University, 3-3-1 Kichijoji-kita machi, Musashino 180-8633, Japan.

The two-dimensional quadratic lattice magnet, bis(glycolato)cobalt(ii) ([Co(HOCH2CO2)2]), showed antiferromagnetic ordering at 15.0 K and an abrupt increase in magnetisation at H = 22 600 Oe and 2 K, thereby acting as a metamagnet. Heat capacity measurements revealed that the associated entropy change ΔS around the transition temperature was evaluated to be 6. Read More

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December 2018
4 Reads

Institutional patient accrual volume and the treatment quality of I‑125 prostate seed implantation in a Japanese nationwide prospective cohort study.

Strahlenther Onkol 2018 Dec 5. Epub 2018 Dec 5.

Japanese Foundation for Prostate Research, Tokyo, Japan.

Purpose: It is unclear whether experience at high-volume institute improves the treatment quality of prostate seed implantation. The aim of this study was to evaluate the effect of institutional experience on postimplant dosimetric parameters in a nationwide prospective cohort study.

Methods: From July 2005 to June 2007, 2354 patients were registered in the Japanese Prostate Cancer Outcome Study of Permanent I‑125 Seed Implantation (J-POPS), and 1126 patients treated with seed implantation alone were evaluated. Read More

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December 2018
2 Reads

Improved Visualization of Middle Ear Cholesteatoma with Computed Diffusion-weighted Imaging.

Magn Reson Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University.

Computed DWI (cDWI) is a mathematical technique that calculates arbitrary higher b value images from at least two different lower b values. In addition, the removal of high intensity noise with image processing on cDWI could improve cholesteatoma-background contrast-to-noise ratio (CNR). In the present study, noise reduction was performed by the cut-off values of apparent diffusion coefficient (ADC) less than 0 and 0. Read More

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December 2018
2 Reads

Eradication of central nervous system leukemia of T-cell origin with a brain-permeable LSD1 inhibitor.

Clin Cancer Res 2018 Dec 5. Epub 2018 Dec 5.

Stem Cell Regulation, Jichi Medical University

Purpose: Lysine-specific demethylase 1 (LSD1) regulates several biological processes via the bifunctional modulation of enhancer functions. Recently, we reported that LSD1 overexpression is a founder abnormality of T-cell leukemogenesis and is maintained in fully transformed T-cell acute lymphoblastic leukemia (T-ALL) cells. On the basis of this finding, we attempted to develop novel LSD1 inhibitors effective for T-ALL with central nervous system (CNS) involvement. Read More

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December 2018
1 Read

Assessment of HIV prevalence among MSM in Tokyo using self-collected dried blood spots delivered through the postal service.

BMC Infect Dis 2018 Dec 5;18(1):627. Epub 2018 Dec 5.

AIDS Clinical Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: Men who have sex with men (MSM) are at high risk of HIV infection. However, there are only few data on HIV prevalence in MSM in Japan. The objective of this study was to explore the HIV prevalence in MSM at Shinjuku 2-chome, a well known gay quarter in Tokyo. Read More

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December 2018

Distribution of liver stiffness in nonalcoholic fatty liver disease with higher Fibrosis-4 index than low cut-off index.

J Gastroenterol Hepatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Japan.

Background And Aim: In the condition of high prevalence of nonalcoholic fatty liver disease (NAFLD), a new diagnostic algorithm to efficiently identify NAFLD patients with significant fibrosis is urgently required. We evaluated the predictive ability of the Fibrosis-4 index (FIB-4 index) for significant liver fibrosis (F ≥ 2) in a cohort of Japanese patients with NAFLD.

Methods: We prospectively calculated the FIB-4 index in patients who were incidentally diagnosed as fatty liver in medical checkups, and then conducted liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) only in patients in whom the FIB-4 index was more than the low cut-off index (> 1. Read More

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December 2018
4 Reads

Is transperitoneal laparoscopic radical nephrectomy suitable for patients with a history of abdominal surgery?

Asian J Endosc Surg 2018 Dec 2. Epub 2018 Dec 2.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Introduction: Laparoscopic radical nephrectomy is the gold standard for treatment of renal cell carcinoma. However, previous abdominal surgery is generally regarded as a contraindication to the laparoscopic approach because it causes intraperitoneal adhesions, which are thought to interfere with subsequent laparoscopic procedures inside the abdominal cavity. Few studies have examined the influence of prior surgery on laparoscopic nephrectomy. Read More

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December 2018
1 Read

Volumetric analysis of the thymic epithelial tumors: correlation of tumor volume with the WHO classification and Masaoka staging.

J Thorac Dis 2018 Oct;10(10):5822-5832

Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background: The purpose of our study was to investigate the correlation between tumor volume (TV) and each subtype of thymic epithelial tumors (TETs) based on the World Health Organization (WHO) classification and Masaoka staging.

Methods: Sixty-one consecutive patients (45 thymomas and 16 thymic carcinomas) were studied. All were classified according to Masaoka staging: 31 non-invasive TETs (stage I) and 30 invasive TETs (8 stage II, 11 stage III, 3 stage IVa, and 8 stage IVb). Read More

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October 2018
1 Read

Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling.

Cell Rep 2018 Dec;25(10):2716-2728.e3

Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo 156-8502, Japan. Electronic address:

Training-dependent increases in c-fos have been used to identify engram cells encoding long-term memories (LTMs). However, the interaction between transcription factors required for LTM, including CREB and c-Fos, and activating kinases such as phosphorylated ERK (pERK) in the establishment of memory engrams has been unclear. Formation of LTM of an aversive olfactory association in flies requires repeated training trials with rest intervals between trainings. Read More

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December 2018

Status and trends in the use of insulin analogs, insulin delivery systems and their association with glycemic control: comparison of the two consecutive recent cohorts of Japanese children and adolescents with type 1 diabetes mellitus.

J Pediatr Endocrinol Metab 2018 Dec 5. Epub 2018 Dec 5.

The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT), Kyoto, Japan.

Background Treatment for type 1 diabetes mellitus (T1DM) has greatly changed by the general use of insulin analogs and continuous subcutaneous insulin infusion (CSII). To investigate whether these advances have been translated into continued improvement in glycemic control in Japanese children and adolescents, we analyzed the registration data of the two consecutive recent cohorts of Japanese childhood-onset T1DM patients. Methods The registration data including hemoglobin A1c (HbA1c), hypoglycemia and insulin regimen were compared between the two cohorts (862 patients in the 2008 cohort and 1090 in the 2013 cohort). Read More

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December 2018
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Comparison of the Effects of Epidural Analgesia and Patient-controlled Intravenous Analgesia on Postoperative Pain Relief and Recovery After Laparoscopic Gastrectomy for Gastric Cancer.

Surg Laparosc Endosc Percutan Tech 2018 Dec 3. Epub 2018 Dec 3.

Departments of Gastroenterological Surgery.

Purpose: Epidural analgesia (EDA) is an imperative modality for postoperative pain relief after major open abdominal surgery. However, whether EDA has benefits in laparoscopic surgery has not been clear. In this study, the effects of EDA and patient-controlled intravenous analgesia (PCIA) after laparoscopic distal gastrectomy (LDG) were compared. Read More

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December 2018
1 Read

A New and Unexpected Spatial Relationship Between Interaction Volume and Diffraction Pattern in Electron Microscopy in Transmission.

Microsc Microanal 2018 Dec 5:1-13. Epub 2018 Dec 5.

1Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux (LEM3),Université de Lorraine,UMR CNRS 7239,57045 Metz,France.

The finding of this study is that the interaction volume in electron microscopy in transmission is well ordered laterally, with a remarkable and unexpected consequence being that lateral subsections of the interaction volume produce subsections of the Kikuchi diffraction pattern. It makes the microstructure of samples directly visible in Kikuchi patterns. This is first illustrated with polycrystalline Ti-10Al-25Nb with an on-axis transmission Kikuchi diffraction set-up in a scanning electron microscope. Read More

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December 2018
2 Reads

Mapping versatile QTL for soybean downy mildew resistance.

Theor Appl Genet 2018 Dec 4. Epub 2018 Dec 4.

Division of Basic Research, Institute of Crop Science, National Agricultural and Food Research Organization (NARO), 2-1-2 Kannondai, Tsukuba, Ibaraki, 305-8518, Japan.

Key Message: Three versatile QTL for soybean downy mildew resistance in Japan were detected using five RIL populations and confirmed using recombinant fixed pairs or a backcrossed line. Downy mildew reduces soybean seed quality and size. It is a problem in Japan, where 90% of soybean grown is used as food. Read More

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December 2018

Mood stabilizers as an Achilles' heel for indication-based nomenclature and roles of Neuroscience-based Nomenclature.

Psychiatry Clin Neurosci 2018 12;72(12):854-855

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.

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December 2018
1 Read

Brief Report: Evaluating the Utility of Varied Technological Agents to Elicit Social Attention from Children with Autism Spectrum Disorders.

J Autism Dev Disord 2018 Dec 3. Epub 2018 Dec 3.

Research Center for Child Mental Development, Kanazawa University, 13-1, Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.

Technological agents could be effective tools to be used in interventions for enhancing social orienting for some young children with ASD. We examined response to social bids in preschool children with ASD and typical development (TD) at a very early age (i.e. Read More

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December 2018
7 Reads

Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells.

Cell Mol Gastroenterol Hepatol 2019 14;7(1):73-91. Epub 2018 Sep 14.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address:

Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells . We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas. Read More

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September 2018
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Association Between Magnetoencephalographic Interictal Epileptiform Discharge and Cognitive Function in Young Children With Typical Development and With Autism Spectrum Disorders.

Front Psychiatry 2018 19;9:568. Epub 2018 Nov 19.

Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Electroencephalograms of individuals with autism spectrum disorders (ASD) show higher rates of interictal epileptiform discharges (IEDs), which are known to have an inverse association with cognitive function in typically developed (TD) children. Nevertheless, that phenomenon has not been investigated adequately in children with ASD. From university and affiliated hospitals, 163 TD children (84 male, 79 female, aged 32-89 months) and 107 children (85 male, 22 female, aged 36-98 months) with ASD without clinical seizure were recruited. Read More

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November 2018
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Immunohistochemical Study of the Laminin α5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands.

Acta Histochem Cytochem 2018 Oct 13;51(5):145-152. Epub 2018 Sep 13.

Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Tochigi, Japan.

Laminin, a major basement membrane protein, comprises three subunit chains: α, β, and γ chains. Among these chains, only the laminin α chain is capable of signaling via laminin receptors. Although laminin isoforms containing the α5 chain were reported to be the first laminin produced during rat anterior pituitary gland development, the functions of these isoforms are unknown. Read More

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October 2018
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