4,210 results match your criteria Kikuchi Disease


Kikuchi-Fujimoto Disease Associated with Sjögren's Syndrome: A Case Report.

Eur J Case Rep Intern Med 2018 25;5(5):000856. Epub 2018 May 25.

Rheumatology Department, Hamad Medical Corporation, Doha, Qatar.

Kikuchi-Fujimoto disease (KFD) or Kikuchi histiocytic necrotizing lymphadenitis, is an extremely rare, benign and self-limiting disease which can be confused with lymphoma and sometime with infections such as tuberculosis. It has also been infrequently reported in association with autoimmune diseases. KFD shares sex and age predisposition as well as histological features with systemic lupus erythematosus. Read More

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http://dx.doi.org/10.12890/2018_000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346929PMC
May 2018
3 Reads

Review of the efficacy of AST-120 (KREMEZIN) on renal function in chronic kidney disease patients.

Ren Fail 2019 Nov;41(1):47-56

a Kureha Corporation , Tokyo , Japan.

AST-120 (KREMEZIN®) consists of oral, spherical carbon particles that adsorb uremic toxins and their precursors within the gastrointestinal tract, allowing them to be excreted in the feces. Uremic toxins such as indoxyl sulfate and p-cresyl sulfate are abundant in the blood of chronic kidney disease (CKD) patients and are related to the progression of both CKD and cardiovascular disease. AST-120 was approved in Japan in 1991 followed by Korea (2004), Taiwan (2007) and the Philippines (2010) for treating uremic symptoms and prolonging the time to initiation of dialysis in patients with progressive CKD. Read More

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November 2019
2 Reads

Atypical temporal-scale-specific fractal changes in Alzheimer's disease EEG and their relevance to cognitive decline.

Cogn Neurodyn 2019 Feb 8;13(1):1-11. Epub 2018 Oct 8.

4Department of Neuropsychiatry, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji, Yoshida, Fukui, 910-1193 Japan.

Recent advances in nonlinear analytic methods for electroencephalography have clarified the reduced complexity of spatiotemporal dynamics in brain activity observed in Alzheimer's disease (AD). However, there are far fewer studies exploring temporal scale dependent fractal properties in AD, despite the importance of studying the dynamics of brain activity within physiologically relevant frequency ranges. Higuchi's fractal dimension is a widely used index for evaluating fractality in brain activity, but temporal-scale-specific characteristics are lost due to its requirement of averaging over the entire range of temporal scales. Read More

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http://dx.doi.org/10.1007/s11571-018-9509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339858PMC
February 2019
1 Read

[Bacteriocidal effects of introducing copper products on highly touched areas in hematology ward].

Rinsho Ketsueki 2019 ;60(1):3-6

Division of Hematology, Department of Medicine, Keio University School of Medicine.

Nosocomial infection via the hospital environment is a serious problem, and highly touched surfaces are the main route of transmission. Copper has been reported to possess bacteriocidal effects, and the introduction of copper-impregnated products is receiving attention as a potential component of hospital infection control. In this study, copper-impregnated door handles as highly touched areas were introduced in a hematology ward, and their bacteriocidal effects were evaluated in comparison with conventional products. Read More

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http://dx.doi.org/10.11406/rinketsu.60.3DOI Listing
January 2019

Feasibility and safety of jailed-pressure wire technique using durable optical fiber pressure wire for intervention of coronary bifurcation lesions.

Catheter Cardiovasc Interv 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiovascular Medicine, Gifu Heart Center, Gifu, Japan.

Objectives: The objective was to evaluate the safety, feasibility, and accuracy of the jailed-pressure wire technique using a durable optical fiber-based pressure wire with high-pressure dilatation using a non-compliant balloon after main vessel stenting.

Background: Fractional flow reserve (FFR) information can help interventionists determine whether they should treat a jailed-side branch (SB). However, re-crossing a pressure wire into a jailed-SB is sometimes technically difficult. Read More

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http://dx.doi.org/10.1002/ccd.28106DOI Listing
February 2019

Sulfasalazine may modulate the CD44v9-xCT system and enhance CDDP-induced cytotoxic effects in metastatic bladder cancer.

Cancer Sci 2019 Feb 4. Epub 2019 Feb 4.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

The prognostic role of CD44v9, a variant isoform of CD44 and a new cell surface marker of cancer stem cells, remains unclear in bladder cancer (BC) patients. Furthermore, limited information is available on the functional role of sulfasalazine (SSZ), which may modulate the CD44v9-xCT system in order to enhance CDDP-induced cytotoxicity and inhibit the metastatic potential of BC. CD44v9 protein expression was examined immunohistochemically in 63 muscle invasive BC (MIBC) patients who underwent radical cystectomy. Read More

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http://dx.doi.org/10.1111/cas.13960DOI Listing
February 2019

A Catastrophic Case of Idiopathic Cholesterol Crystal Embolism with Multiple Lethal Complications: A Labyrinth Underneath the Diagnosis of Skin Ulcers in Chronic Kidney Disease Patients.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Japan.

A 66-year-old man was admitted to our hospital because of multiple refractory skin ulcers. Based on his severe systemic arterial calcification and severe calcium-phosphate imbalance due to severe kidney dysfunction, we initially considered calciphylaxis. However, a skin biopsy provided a diagnosis of cholesterol crystal embolization. Read More

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http://dx.doi.org/10.2169/internalmedicine.2378-18DOI Listing
February 2019
1 Read

Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta-thalassemia.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of General Internal Medicine, Hiroshima University Hospital, Japan.

Acute chest syndrome (ACS), characterized by fever, respiratory symptoms, and new pulmonary infiltration, is a serious complication of sickle cell disease (SCD). Regardless of the etiology, the conventional treatment options for ACS include empirical antibiotic therapy, the administration of analgesics, and red cell transfusion. The indications and methods of red cell transfusion are critical. Read More

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http://dx.doi.org/10.2169/internalmedicine.1753-18DOI Listing
February 2019
2 Reads

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study).

Ann Gastroenterol Surg 2019 Jan 11;3(1):96-103. Epub 2018 Oct 11.

Department of Gastroenterological Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

Aim: As a result of the difficulty in effective prevention of gastroesophageal reflux, no standard reconstruction procedure after proximal gastrectomy (PG) has yet been established. The double-flap technique (DFT), or Kamikawa procedure, is an antireflux reconstruction procedure in esophagogastrostomy. The efficacy of DFT has recently been reported in several studies. Read More

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http://dx.doi.org/10.1002/ags3.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345660PMC
January 2019
1 Read

Kikuchi-Fujimoto disease with relapsing polychondritis.

Rheumatology (Oxford) 2019 Jan 28. Epub 2019 Jan 28.

Department of Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/key449DOI Listing
January 2019
1 Read
4.475 Impact Factor

POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.

Sci Rep 2019 Jan 14;9(1):102. Epub 2019 Jan 14.

Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.

Primary biliary cholangitis (PBC) is a chronic and cholestatic autoimmune liver disease caused by the destruction of intrahepatic small bile ducts. Our previous genome-wide association study (GWAS) identified six susceptibility loci for PBC. Here, in order to further elucidate the genetic architecture of PBC, a GWAS was performed on an additional independent sample set, then a genome-wide meta-analysis with our previous GWAS was performed based on a whole-genome single nucleotide polymorphism (SNP) imputation analysis of a total of 4,045 Japanese individuals (2,060 cases and 1,985 healthy controls). Read More

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http://dx.doi.org/10.1038/s41598-018-36490-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331557PMC
January 2019
3 Reads

Take a second look: it's Kikuchi's disease! A case report and review of literature.

Clin Pract 2018 Oct 12;8(4):1095. Epub 2018 Dec 12.

Department of Immunology and Rheumatology.

Generalized lymphadenopathy is a common cause of concern for both patients and clinicians. Possible etiologies include infections, malignancies and autoimmune diseases. Kikuchi Fujimoto disease (KFD) is a hyperergic condition that presents with fever, lymphadenopathy and can include systemic involvement, thus being easily mistaken for the above-mentioned entities. Read More

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http://dx.doi.org/10.4081/cp.2018.1095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297864PMC
October 2018

Cross-sectional multicenter observational study of psoriatic arthritis in Japanese patients: Relationship between skin and joint symptoms and results of treatment with tumor necrosis factor-α inhibitors.

J Dermatol 2019 Jan 10. Epub 2019 Jan 10.

Department of Dermatology, Fukuyama City Hospital, Fukuyama, Japan.

Psoriatic arthritis (PsA) is an inflammatory arthritis with as yet unclear pathophysiology. This retrospective, multicenter, cross-sectional study was conducted in 19 facilities in western Japan and aimed to identify patients' characteristics and factors that affect the results of treatment with biologic agents. Of 2116 patients with psoriasis, 285 (13. Read More

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http://dx.doi.org/10.1111/1346-8138.14745DOI Listing
January 2019
2 Reads

Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome.

Clin Sci (Lond) 2019 Jan 25;133(2):321-334. Epub 2019 Jan 25.

Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, U.S.A.

Acute respiratory distress syndrome (ARDS) in a deadly disease that can be brought on by endotoxins such as lipopolysaccharide (LPS). ARDS is characterized by vascular permeability, a severe inflammatory response, lung leukocyte infiltration, and resultant lung edema. Polymerase δ-interacting protein 2 (Poldip2) is a novel regulator of blood-brain barrier permeability; however, its role in regulating lung permeability and vascular inflammation is unknown. Read More

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http://clinsci.org/lookup/doi/10.1042/CS20180944
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http://dx.doi.org/10.1042/CS20180944DOI Listing
January 2019
7 Reads

Reference values of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire in patients with lumbar spinal stenosis and characteristics of deterioration of QOL: Lumbar Spinal Stenosis Diagnosis Support Tool: DISTO project.

J Orthop Sci 2019 Jan 4. Epub 2019 Jan 4.

Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.

Background: The reference values of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) in patients with lumbar spinal stenosis (LSS) are still unknown. This multicenter cross-sectional survey was performed to determine the reference values and disease-specific characteristics of deterioration of QOL caused by LSS itself, not by aging, through comparison of patients with and without LSS who had an outpatient visit for low back pain by age and sex groups.

Methods: The present study was performed at 564 medical centers and clinics. Read More

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http://dx.doi.org/10.1016/j.jos.2018.11.022DOI Listing
January 2019
1 Read

Serum Uric Acid to Creatinine Ratio Independently Predicts Incident Metabolic Syndrome Among Community-Dwelling Persons.

Metab Syndr Relat Disord 2019 Jan 7. Epub 2019 Jan 7.

1 Department of Community Medicine, Ehime University Graduate School of Medicine , Toon, Japan .

Background: Metabolic syndrome (MetS) is related to the increased risk of major cardiovascular disease. The link between high serum uric acid (SUA) and creatinine (Cr) levels is causally related to MetS and its components. However, whether renal function-normalized SUA [i. Read More

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https://www.liebertpub.com/doi/10.1089/met.2018.0055
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http://dx.doi.org/10.1089/met.2018.0055DOI Listing
January 2019
5 Reads

Anti-angiogenic isoform of vascular endothelial growth factor-A in cardiovascular and renal disease.

Adv Clin Chem 2019 16;88:1-33. Epub 2018 Nov 16.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Accumulating evidence suggests that pathologic interactions between the heart and the kidney can contribute to the progressive dysfunction of both organs. Recently, there has been an increase in the prevalence of cardiovascular disease (CVD) and chronic kidney disease (CKD) due to increasing obesity rates. It has been reported that obesity causes various heart and renal disorders and appears to accelerate their progression. Read More

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http://dx.doi.org/10.1016/bs.acc.2018.10.001DOI Listing
November 2018

Association of neutrophil-to-lymphocyte ratio with early renal dysfunction and albuminuria among diabetic patients.

Int Urol Nephrol 2019 Jan 3. Epub 2019 Jan 3.

Department of Community Medicine, Ehime University Graduate School of Medicine, Toon-city, 791-0295, Japan.

Purpose: Neutrophil-to-lymphocyte ratio (NLR) was widely studied as a prognostic marker in various medical and surgical specialties, but its significance in diabetic kidney disease is not yet established.

Methods: The subjects comprised 199 men aged 73 ± 11 (mean ± standard deviation) years and 187 women aged 77 ± 10 years from a rural hospital. We examined the relationship between NLR calculated by analyzing differential leukocyte count in complete blood picture and renal function evaluated by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study Group equation and urinary albumin excretion (UAE). Read More

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http://dx.doi.org/10.1007/s11255-018-02065-2DOI Listing
January 2019
1 Read

Castration-resistant prostate cancer patients who had poor response on first androgen deprivation therapy would obtain certain clinical benefit from early docetaxel administration.

Int J Clin Oncol 2019 Jan 2. Epub 2019 Jan 2.

Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Our specific aim was to investigate the prognostic value of effective duration of first androgen deprivation therapy (ADT) and to evaluate the clinical impact on early docetaxel administration with oncological outcomes in castration-resistant prostate cancer (CRPC) patients treated with docetaxel.

Methods: We identified 148 mCRPC patients who were treated with 75 mg/m docetaxel. We defined 16 months as the threshold for the effective duration of ADT, and defined 12 months as the cut-off time for starting docetaxel from the onset of CRPC. Read More

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http://dx.doi.org/10.1007/s10147-018-01388-5DOI Listing
January 2019

Mesenchymal Stem Cell Marker Expression in Gastric Cancer Stroma.

Anticancer Res 2019 Jan;39(1):387-393

Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.

Background/aim: Spindle-shaped stromal cells of tumors are derived from various cellular origins, including mesenchymal stem cells (MSCs). MSCs express CD73, CD90 and CD105 antigens. Herein, the aim was to investigate the association between the expression of specific MSC markers in gastric cancer stromal cells and the clinicopathological features of the disease. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13124DOI Listing
January 2019
13 Reads

Cutaneous lupus with Kikuchi disease-like inflammatory pattern associated with myelodysplastic syndrome.

Rheumatology (Oxford) 2018 Dec 19. Epub 2018 Dec 19.

Department of Internal Medicine, APHP, Saint Antoine Hospital, Sorbonne Université, France.

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http://dx.doi.org/10.1093/rheumatology/key413DOI Listing
December 2018
3 Reads

Haploidentical transplantation using low-dose alemtuzumab: Comparison with haploidentical transplantation using low-dose thymoglobulin.

Eur J Haematol 2019 Mar 9;102(3):256-264. Epub 2019 Jan 9.

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Objectives: To establish the optimal strategy for haploidentical hematopoietic stem cell transplantation (HSCT).

Methods: We performed a prospective study on haploidentical HSCT using low-dose alemtuzumab. Alemtuzumab was added at 0. Read More

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http://doi.wiley.com/10.1111/ejh.13204
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http://dx.doi.org/10.1111/ejh.13204DOI Listing
March 2019
7 Reads

The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial.

JMIR Res Protoc 2018 12 21;7(12):e12046. Epub 2018 Dec 21.

Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects the upper and lower motor neurons. Currently, only riluzole and edaravone are approved as drugs to treat ALS and new agents with larger effect sizes are warranted. Exploratory analyses in our previous study (study ID #E0302-J081-761) have suggested that high-dose methylcobalamin (E0302) prolonged the overall survival of ALS patients and suppressed ALS progression in patients with a disease duration of less than 12 months. Read More

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http://www.researchprotocols.org/2018/12/e12046/
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http://dx.doi.org/10.2196/12046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320396PMC
December 2018
6 Reads

Successful Steroid Therapy for Lipoid Pneumonia Developing After Allogeneic Hematopoietic Stem Cell Transplant: A Case Report.

Transplant Proc 2018 Dec 8;50(10):4096-4098. Epub 2018 Sep 8.

Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Lipoid pneumonia is an uncommon noninfectious inflammatory lung disease characterized by lipid deposition in the alveoli, and its etiology and treatment have not been elucidated. We report the case of a 32-year-old woman who developed lipoid pneumonia 9 months after allogeneic hematopoietic stem cell transplant for chronic myelogenous leukemia in lymphoid blast crisis. She complained of progressive cough and dyspnea shortly after discontinuation of immunosuppressive therapy given for graft-vs-host disease. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.09.004DOI Listing
December 2018
1 Read

Case of autoimmune intraepidermal and subepidermal blistering disease in which autoantibodies to desmoglein 1 and BP230 coexist.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1111/1346-8138.14734DOI Listing
December 2018

Effects of body position during cardiopulmonary exercise testing with right heart catheterization.

Physiol Rep 2018 Dec;6(23):e13945

Division of Cardiology, Department of Medicine, Kyorin University Hospital, Mitaka, Tokyo, Japan.

Cardiopulmonary exercise testing (CPX) with right heart catheterization (RHC) widely used for early diagnosis and evaluation of pulmonary vascular disease in patients with pulmonary arterial hypertension and early stage heart failure with preserved ejection fraction, who display normal hemodynamics at rest. The aim of this study was to investigate that whether body position affects pulmonary hemodynamics, pulmonary arterial wedge pressure (PAWP), and CPX parameters during invasive CPX. Seventeen patients (58 ± 14 years; 5/12 male/female) with chronic thromboembolic pulmonary hypertension treated with percutaneous transluminal pulmonary angioplasty and near-normal pulmonary artery pressure (PAP) underwent invasive CPX twice in supine and upright position using a cycle ergometer with 6 months interval. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.14814/phy2.13945
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http://dx.doi.org/10.14814/phy2.13945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289908PMC
December 2018
19 Reads

Immunoglobulin G4-Related Disease Arising from the Bladder Wall.

Urol Int 2018 Dec 13:1-3. Epub 2018 Dec 13.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a recently described inflammatory disease with multiorgan involvement. Although there were reports of IgG4-related kidney disease or prostatitis, this disease rarely presents in the bladder. In this report, we describe a case of IgG4-RD arising from bladder wall. Read More

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http://dx.doi.org/10.1159/000495570DOI Listing
December 2018
1 Read

Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.

Digestion 2018 Dec 12:1-10. Epub 2018 Dec 12.

Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Background/aims: Behçet's disease (BD) with intestinal lesions and Crohn's disease (CD) share clinical features. However, no report has compared the 2 diseases with regard to lesions of the upper gastrointestinal tract (UGT). We aimed to evaluate endoscopic and histologic findings of UGT in CD and BD. Read More

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http://dx.doi.org/10.1159/000494922DOI Listing
December 2018
1 Read

The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer.

J Exp Clin Cancer Res 2018 Dec 11;37(1):307. Epub 2018 Dec 11.

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: The peritoneum is one of the most frequent metastatic sites in pancreatic cancer patients, and peritoneal dissemination makes this disease refractory due to aggressive progression and chemoresistance. Although the role of the tumor microenvironment in cancer development is recognized, the correlation between the peritoneal environment and refractoriness of peritoneal dissemination remains unclear. The intraperitoneal tumor-microenvironment and its potential role in the progression of peritoneal dissemination and chemo-refractoriness, focusing especially on macrophages, were investigated. Read More

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http://dx.doi.org/10.1186/s13046-018-0981-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288926PMC
December 2018
3 Reads

[Thrombotic microangiopathy developing subsequent to tocilizumab therapy in a patient with TAFRO syndrome].

Rinsho Ketsueki 2018;59(11):2432-2437

Department of Pathology, Hakodate Municipal Hospital.

We report a case of a 60-year-old male who presented with fever and anasarca as well as hepatosplenomegaly, general lymphadenopathy, and disseminated intravascular coagulation (DIC), and was, therefore, admitted to our hospital. In addition, the patient suffered from respiratory failure and renal dysfunction and had pleural effusion and ascites. The pathological diagnosis from lymph node biopsy suggested multicentric Castleman's disease of the plasma cell type; however, the presence of high IL-6 levels, myelofibrosis, thrombocytopenia, anasarca, renal dysfunction, and hepatosplenomegaly led to a definitive diagnosis of TAFRO syndrome. Read More

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http://dx.doi.org/10.11406/rinketsu.59.2432DOI Listing
January 2018
1 Read

Coexistence of systemic lupus erythematosus with Kikuchi-Fujimoto disease involving the salivary gland, initially disguised as lymphoma.

Rheumatology (Oxford) 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Department of Internal Medicine, Jeonju, Republic of Korea.

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http://dx.doi.org/10.1093/rheumatology/key353DOI Listing
December 2018
2 Reads

Distribution of liver stiffness in non-alcoholic fatty liver disease with higher fibrosis-4 index than low cut-off index.

J Gastroenterol Hepatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Background And Aim: In the condition of high prevalence of non-alcoholic fatty liver disease (NAFLD), a new diagnostic algorithm to efficiently identify NAFLD patients with significant fibrosis is urgently required. We evaluated the predictive ability of the fibrosis-4 index (FIB-4 index) for significant liver fibrosis (F ≥ 2) in a cohort of Japanese patients with NAFLD.

Methods: We prospectively calculated the FIB-4 index in patients who were incidentally diagnosed as fatty liver in medical checkups and then conducted liver stiffness measurement by vibration-controlled transient elastography (VCTE) only in patients in whom the FIB-4 index was more than the low cut-off index (> 1. Read More

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http://doi.wiley.com/10.1111/jgh.14559
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http://dx.doi.org/10.1111/jgh.14559DOI Listing
December 2018
13 Reads

Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells.

Cell Mol Gastroenterol Hepatol 2019 14;7(1):73-91. Epub 2018 Sep 14.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address:

Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells . We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260338PMC
September 2018
1 Read

Short-term prognosis of emergently hospitalized dialysis-independent chronic kidney disease patients: A nationwide retrospective cohort study in Japan.

PLoS One 2018 29;13(11):e0208258. Epub 2018 Nov 29.

Department of Nephrology, Graduate School of Medicine and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

In patients with chronic kidney disease (CKD), low body mass index (BMI) is associated with high mortality. This relationship in emergently hospitalized CKD patients is unknown. We investigated the association between obesity and short-term mortality in emergently admitted patients with dialysis-independent CKD (DI-CKD) with and without infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208258PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264841PMC
November 2018
1 Read

Clinical characteristics of pyogenic spondylitis and psoas abscess at a tertiary care hospital: a retrospective cohort study.

J Orthop Surg Res 2018 Nov 28;13(1):302. Epub 2018 Nov 28.

Department of Pediatrics, Shimane Prefectural Central Hospital, Izumo, Japan.

Background: Psoas abscess and pyogenic spondylitis are intractable diseases that require long-term treatment, but the clinical characteristics and causative organisms have not been fully investigated. Herein, we describe the clinical characteristics of these diseases and evaluate the factors associated with in-hospital mortality and the presence of gram-negative rods as causative microorganisms.

Methods: All patients diagnosed with pyogenic spondylitis or psoas abscesses at a tertiary hospital were included. Read More

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http://dx.doi.org/10.1186/s13018-018-1005-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264034PMC
November 2018
2 Reads

Methimazole-induced acute pancreatitis: a case report.

Clin J Gastroenterol 2018 Nov 24. Epub 2018 Nov 24.

Department of Infectious Disease, Yokohama Municipal Citizen's Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, Japan.

A 76-year-old Japanese woman was diagnosed with Graves' disease and was administered methimazole (MMI) 10 mg and potassium iodide 50 mg. After 19 days of the drug regime, she developed high-grade fever and nausea and was admitted to our hospital. Blood test results showed elevated pancreatic enzymes and C-reactive protein levels. Read More

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http://link.springer.com/10.1007/s12328-018-0926-5
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http://dx.doi.org/10.1007/s12328-018-0926-5DOI Listing
November 2018
9 Reads

Development of a novel convenient Alzheimer's disease assessment scale, the ABC Dementia Scale, using item response theory.

Geriatr Gerontol Int 2019 Jan 22;19(1):18-23. Epub 2018 Nov 22.

Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Aim: The present study aimed to assess the interrater reliability and construct the validity of a novel, convenient informant-based Alzheimer's disease assessment scale to prepare its final version.

Methods: For the assessment, site investigators, co-medicals and, if available, medical staff other than doctors or co-medicals interviewed study informants to assess individuals using this scale. We then analyzed the interrater reliability and construct validity using factor analysis and item response characteristics. Read More

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http://dx.doi.org/10.1111/ggi.13552DOI Listing
January 2019
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Association of pyoderma gangrenosum, erythema nodosum and aseptic liver abscess without significant underlying disease.

Clin Exp Dermatol 2019 Mar 20;44(2):e16-e17. Epub 2018 Nov 20.

Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima, 960 1295, Japan.

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http://dx.doi.org/10.1111/ced.13838DOI Listing
March 2019
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Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease.

Kidney Int 2019 Jan 16;95(1):123-137. Epub 2018 Nov 16.

Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

The kidneys consume a large amount of energy to regulate volume status and blood pressure and to excrete uremic toxins. The identification of factors that cause energy mismatch in the setting of chronic kidney disease (CKD) and the development of interventions aimed at improving this mismatch are key research imperatives. Although the critical cellular energy sensor 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is known to be inactivated in CKD, the mechanism of AMPK dysregulation is unknown. Read More

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http://dx.doi.org/10.1016/j.kint.2018.08.030DOI Listing
January 2019
10 Reads

The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer.

Sci Rep 2018 Nov 19;8(1):16997. Epub 2018 Nov 19.

Department of Gastroenterology, Fukushima Medical University, School of Medicine, Fukushima, Japan.

In this study, we determined the efficacy of the cell death biomarker cytokeratin 18 for diagnosing biliary tract cancer (BTC). We recruited 36 patients with BTC (Malignant group) and 45 patients with benign biliary tract disease (Benign group) for this study. We used M30 and M65 as cell death biomarkers. Read More

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http://www.nature.com/articles/s41598-018-35278-7
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http://dx.doi.org/10.1038/s41598-018-35278-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243019PMC
November 2018
11 Reads

Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice.

Front Immunol 2018 2;9:2534. Epub 2018 Nov 2.

Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.

There is considerable interest in expanding B cell-targeted therapies in human autoimmune diseases. However, clinical trials in human primary biliary cholangitis (PBC) using a chimeric antibody against human CD20 (hCD20) have showed limited efficacy. Two potential explanations for these disappointing results are the appearance of anti-drug antibodies (ADAs) and the high frequency of patients with moderate PBC or patients who had failed ursodeoxycholic acid treatment. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02534
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http://dx.doi.org/10.3389/fimmu.2018.02534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224429PMC
November 2018
11 Reads

Laser speckle flowgraphy can also be used to show dynamic changes in the blood flow of the skin of the foot after surgical revascularization.

Vascular 2018 Nov 12:1708538118810664. Epub 2018 Nov 12.

1 Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Japan.

Objectives: Laser speckle flowgraphy is a new method that enables the rapid evaluation of foot blood flow without contact with the skin. We used laser speckle flowgraphy to evaluate foot blood flow in peripheral arterial disease patients before and after surgical revascularization.

Materials And Methods: A prospective single-center study. Read More

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http://dx.doi.org/10.1177/1708538118810664DOI Listing
November 2018
2 Reads

Kikuchi-Fujimoto Disease: A Review.

Arch Pathol Lab Med 2018 Nov;142(11):1341-1346

From the Section of Hematopathology, Department of Pathology, University of Michigan, Ann Arbor.

Kikuchi-Fujimoto disease (KFD) is a rare entity characterized by subacute necrotizing lymphadenopathy and frequently associated with fever. Young adults of Asian ancestry are most commonly affected, but it has been reported worldwide. Despite many studies in the literature, the cause of KFD remains uncertain. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-021
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http://dx.doi.org/10.5858/arpa.2018-0219-RADOI Listing
November 2018
19 Reads

Lymph node metastasis and high serum CEA are important prognostic factors in hormone receptor positive and HER2 negative breast cancer.

Mol Clin Oncol 2018 Nov 13;9(5):566-574. Epub 2018 Sep 13.

Department of Surgery, School of Medicine, Kitasato University Hospital, Sagamihara, Kanagawa 252-0374, Japan.

In recent years, treatment options for breast cancer have increased, and prognosis has improved since the 1990s. The present study examined the prognosis for recurrence of breast cancer between 2006 and 2009, in comparison with the results of past treatments, and sought to guide future treatment strategies by elucidating present prognostic factors. A total of 662 patients with breast cancer stage 0-III who underwent surgery at Kitasato University Hospital between January 2006 and March 2009 were included. Read More

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http://www.spandidos-publications.com/10.3892/mco.2018.1716
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http://dx.doi.org/10.3892/mco.2018.1716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201040PMC
November 2018
3 Reads

Fatal Vasospasm of the Coronary Arteries in a Patient Undergoing Distal Bypass Surgery and Endovascular Therapy for Threatened Lower Limbs Due to Acute Exacerbation of Peripheral Arterial Disease.

Ann Vasc Dis 2018 Sep;11(3):369-372

Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

A 79-year-old man with a heavy smoking history presented with threatened lower limbs due to acute exacerbation of peripheral artery disease (PAD). He underwent emergent distal bypass surgery for the right leg and external iliac stenting for the left leg. Fatal coronary artery spasm (CAS) with ST segment changes on electrocardiography was observed 28 h after the procedures, resulting in cardiac arrest. Read More

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https://www.jstage.jst.go.jp/article/avd/11/3/11_cr.18-00050
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http://dx.doi.org/10.3400/avd.cr.18-00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200607PMC
September 2018
11 Reads

Successful Simultaneous Revascularization for Acute Limb Ischemia and Concomitant Acute Myocardial Infarction.

Ann Vasc Dis 2018 Sep;11(3):361-364

Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

Acute limb ischemia (ALI) is associated with high morbidity and mortality rates, even with the advent of technical advances. Although myocardial infarction is one of the causes of ALI along with intraventricular thrombus formation and subsequent embolism, ALI with concomitant acute myocardial infarction (AMI) is extremely rare. Here, we report a complicated ALI case with concurrent AMI and prolonged limb ischemic duration. Read More

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https://www.jstage.jst.go.jp/article/avd/11/3/11_cr.18-00059
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http://dx.doi.org/10.3400/avd.cr.18-00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200629PMC
September 2018
4 Reads

Increased risk of non-AIDS-defining cancers in Asian HIV-infected patients: a long-term cohort study.

BMC Cancer 2018 Nov 6;18(1):1066. Epub 2018 Nov 6.

AIDS Clinical Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: Data on the long-term risks of non-AIDS defining cancers (NADCs) are limited, especially in Asians. The incidence of NADCs may correlate with the epidemiological trend of cancers or oncogenic infection in each country, and thus the target cancers would be different between Western and Asian countries. We aimed to elucidate the incidence of NADCs and its predictive factors in Asian HIV-infected patients. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-018-4963-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219071PMC
November 2018
13 Reads

An α-Lipoic acid derivative, and anti-ROS agent, prevents the acquisition of multi-drug resistance in clinical isolates of Pseudomonas aeruginosa.

J Infect Chemother 2019 Jan 3;25(1):28-33. Epub 2018 Nov 3.

Division of Clinical Infectious Disease & Chemotherapy, Tohoku Medical and Pharmaceutical University Graduate School of Pharmaceutical Sciences, Sendai, Japan. Electronic address:

Pseudomonas aeruginosa is one of the most common causes of nosocomial infections, and its multi-drug resistance has been a serious problem worldwide. The aim of this study was to evaluate whether exposure to piperacillin and reactive oxygen species (ROS) could lead to multi-drug resistance for clinical isolates of P. aeruginosa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1341321X183039
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http://dx.doi.org/10.1016/j.jiac.2018.10.003DOI Listing
January 2019
7 Reads

[A Case of Rectal Colon Cancer with Paraneoplastic Cerebellar Degeneration].

Gan To Kagaku Ryoho 2018 Oct;45(10):1510-1512

Dept. of Gastrointestinal Tract Surgery, Fukushima Medical University.

A case complicated with colorectal and prostate cancers in paraneoplastic(subacute)cerebellar degeneration(PCD)is extremely rare. We report a retrospective case of rectal carcinoma with paraneoplastic cerebellar degeneration. A 79-year-old man with Parkinson's disease was unable to walk because of paralysis. Read More

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October 2018
20 Reads