5,186 results match your criteria Kikuchi Disease


Kikuchi-Fujimoto's Disease or Histiocytic Necrotizing Lymphadenitis Following mRNA COVID-19 Vaccination: A Rare Case.

Cureus 2022 Apr 15;14(4):e24155. Epub 2022 Apr 15.

Department of Hematology, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MAR.

Kikuchi-Fujimoto disease (KFD), also known as necrotizing histiocytic lymphadenopathy, is a rare and benign lymph node disorder that mainly occurs in young women. It is clinically characterized by fever with tender and painful cervical lymphadenopathy mostly; however, all areas of lymph nodes can be involved. This disorder is often mistaken for malignant lymphoma or infection. Read More

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Lean/normal-weight Metabolic Dysfunction-Associated Fatty Liver Disease is a Risk Factor for Reflux Esophagitis.

Hepatol Res 2022 May 18. Epub 2022 May 18.

Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.

Aim: Reflux esophagitis is associated with metabolic dysfunction. Recently, fatty liver has been redefined as metabolic dysfunction-associated fatty liver disease (MAFLD). We investigated the impact of MAFLD and its subtypes on the incidence of reflux esophagitis. Read More

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Multijurisdictional Outbreak of Enterohemorrhagic O157 Caused by Consumption of Ready-to-Eat Grilled Skewered Meat in Niigata, Japan.

Foodborne Pathog Dis 2022 May 17. Epub 2022 May 17.

Niigata City Public Health Center, Niigata, Japan.

Enterohemorrhagic O157 (EHEC) causes severe complications such as hemolytic uremic syndrome. Contaminated ready-to-eat (RTE) food is one of the vehicles of multijurisdictional outbreaks of foodborne disease worldwide. Multijurisdictional (covering cities, towns, and villages) outbreaks of EHEC are usually linked to an increase in cases, and here we describe such an outbreak involving 29 cases in October 2017 in the Niigata Prefecture. Read More

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Kikuchi-Fujimoto disease can present as delayed lymphadenopathy after COVID-19 vaccination.

Hum Vaccin Immunother 2022 May 18:2071080. Epub 2022 May 18.

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Following COVID-19 vaccination, ipsilateral axillary and cervical lymphadenopathy may occur, called vaccine-related hypermetabolic lymphadenopathy, which is considered reactive lymphadenopathy. We report here a case of Kikuchi-Fujimoto disease, which occurred three months after vaccination with COVID-19 vaccine. The patient had cervical and axillary lymph node enlargement and a short-term fever that resolved spontaneously after the first and second vaccines. Read More

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A Malignant Mimicker: Features of Kikuchi-Fujimoto Disease in the Pediatric Population.

Pediatr Dev Pathol 2022 May 18:10935266221103882. Epub 2022 May 18.

Department of Laboratory Medicine and Pathology, 7284University of Washington, Seattle, WA, USA.

Background: Kikuchi-Fujimoto disease (KFD) is a rare, benign, and self-limited disease that presents with cervical lymphadenopathy and systemic symptoms. Histologic evaluation is often necessary to differentiate KFD from other entities.

Methods: Electronic medical records and diagnostic material were reviewed for 14 children diagnosed with KFD and 6 children diagnosed with infectious mononucleosis (IM) from 2013-2021. Read More

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Case Report: Leptospirosis by Wild Rat Bite in Winter in Tokyo Metropolitan Area, Japan.

Am J Trop Med Hyg 2022 May 16. Epub 2022 May 16.

Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.

We report a case of leptospirosis in Tokyo in winter due to a rat bite, an uncommon cause of Leptospira infection. In Japan, many cases due to exposure to fresh water have been reported from domestic southwest islands in summer. However, a previous report on leptospirosis in Tokyo documented several cases occurring in winter. Read More

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The Impact of Chronic Limb-Threatening Ischemia on Cardiac Surgery.

Front Surg 2022 28;9:892309. Epub 2022 Apr 28.

Department of Cardiac Surgery, Asahikawa Medical University, Asahikawa, Japan.

Purpose: The effect of chronic limb threatening ischemia (CLTI) on advanced cardiac disease, which requires surgical treatment, has rarely been reported. The purpose of this study was to review the outcomes of cardiac surgery in patients with CLTI and determine the risk factors, with a particular focus on the severity of CLTI.

Patients: The baseline characteristics and outcomes of 33 patients who were treated for CLTI and underwent cardiac surgery were retrospectively analyzed. Read More

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Hyperuricemia is associated with all-cause mortality among males and females: Findings from a study on Japanese community-dwelling individuals.

Metabol Open 2022 Jun 29;14:100186. Epub 2022 Apr 29.

Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.

Background: Serum uric acid (SUA) is a key determinant of cardiovascular diseases (CVDs). Studies have also shown that SUA independently impacts age-related health outcomes, although their findings differ between males and females. Furthermore, predictive data on all-cause mortality remain limited, particularly for the Japanese population. Read More

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Factors Associated With Prolonged Psychological Distress Among Nurses and Physicians Engaged in COVID-19 Patient Care in Singapore and Japan.

Front Psychiatry 2022 28;13:781796. Epub 2022 Apr 28.

Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital, Tokyo, Japan.

This study explores the factors contributing to the prolonged psychological distress of frontline nurses and physicians caring for COVID-19 patients in hospitals in Singapore and Japan. A cross-sectional survey between September and December 2020 yielded 1,644 responses (23.8%), from 62 nurses and 64 physicians in Singapore and 1,280 nurses and 238 physicians in Japan. Read More

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Women's health status before and during the COVID-19 pandemic in rural Bangladesh: A prospective longitudinal study.

PLoS One 2022 13;17(5):e0266141. Epub 2022 May 13.

Medical Information Center, Kyushu University Hospital, Maidashi, Higashi-ku, Fukuoka, Japan.

The coronavirus disease (COVID-19) pandemic has widely spread worldwide since 2020. Several countries have imposed lockdown or stay-at-home policies to prevent the infection. Bangladesh experienced a lockdown from March 2020 to May 2020, and internal travel was restricted. Read More

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Characteristics of colorectal neuroendocrine tumors in patients prospectively enrolled in a Japanese multicenter study: a first report from the C-NET STUDY.

J Gastroenterol 2022 May 13. Epub 2022 May 13.

Department of Gastroenterology, Kitasato University Hospital, Kanagawa, Japan.

Background: This is the first report from a multicenter prospective cohort study of colorectal neuroendocrine tumor (NET), the C-NET STUDY, conducted to assess the long-term outcomes of the enrolled patients. This report aimed to elucidate the clinicopathological features of the enrolled patients and lesions.

Methods: Colorectal NET patients aged 20-74 years were consecutively enrolled and followed up at 50 institutions. Read More

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leaves suppress sodium dextran sulfate-induced colitis through interleukin-10-related pathway.

Biochem Biophys Rep 2022 Jul 2;30:101272. Epub 2022 May 2.

Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.

Indigo naturalis, a herbal medicine purified from indigo-containing plants, such as and , has been reported to be useful in the treatment of ulcerative colitis by activating the aryl hydrocarbon receptor. However, the aryl hydrocarbon receptor pathway causes crucial side effects, such as pulmonary arterial hypertension. Although is one of the plant derivatives of indigo naturalis, it is not identical to it To date, the pure leaves of have not been reported to ameliorate ulcerative colitis. Read More

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Novel mutations identified in patients with IMAGE-I syndrome cause aberrant subcellular localisation and protein degradation in the nucleus.

J Med Genet 2022 May 9. Epub 2022 May 9.

Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Background: DNA replisome is a molecular complex that plays indispensable roles in normal DNA replication. IMAGE-I syndrome is a DNA replisome-associated genetic disease caused by biallelic mutations in the gene encoding DNA polymerase epsilon catalytic subunit 1 (). However, the underlying molecular mechanisms remain largely unresolved. Read More

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Shigellosis Cases with Bacterial Sexually Transmitted Infections: Population-Based Data from 6 US Jurisdictions, 2007-2016.

Sex Transm Dis 2022 May 5. Epub 2022 May 5.

Centers for Disease Control and Prevention.

Background: Shigella species, which cause acute diarrheal disease, are transmitted via fecal-oral and sexual contact. To better understand the overlapping populations affected by Shigella infections and sexually transmitted infections (STIs) in the United States, we examined the occurrence of reported STIs within 24 months among shigellosis case-patients.

Methods: Culture-confirmed Shigella cases diagnosed during 2007-2016 among residents of six U. Read More

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Combination therapy with von Willebrand factor concentrate plus recombinant factor VIII during cesarean section in a patient with type 3 von Willebrand disease and a low inhibitor titer: a case report.

Int J Hematol 2022 May 9. Epub 2022 May 9.

Department of Laboratory Medicine, Tokyo Medical University, Tokyo, Japan.

Type 3 von Willebrand disease (VWD), a rare and severe subtype, can produce inhibitors in roughly 5% to 10% of cases. We present a case of type 3 VWD with inhibitors in late pregnancy, which was successfully managed with a combination of neutralization and factor (F)VIII replacement during cesarean delivery. The patient, a 30-year-old woman, had no history of inhibitors despite over 100 exposures to VWF/FVIII. Read More

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Spindle cell tumor with histiocytic and myogenic marker expression in the lymph node of a human T-cell leukemia virus type 1 carrier.

Pathol Res Pract 2022 May 2;234:153935. Epub 2022 May 2.

Department of Pathology, Sapporo Medical University, School of Medicine, Sapporo, Japan.

Carriers of oncogenic human T-cell leukemia virus type 1 (HTLV-1) can develop adult T-cell leukemia/lymphoma (ATLL). While an increasing number of animal models of HTLV-1 infection have revealed that malignant tumors with a histiocytic phenotype can arise, they have not been reported in humans. Here, we present a 79-year-old female HTLV-1 carrier who presented with a swollen lymph node. Read More

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Novel antibody assessment method for microbial compositional alteration in the oral cavity.

Biochem Biophys Rep 2022 Jul 29;30:101269. Epub 2022 Apr 29.

Department of Oral Microbiology and Immunology, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8555, Japan.

Recently, it has been demonstrated that dysbiosis, an alteration in commensal microflora composition, is intimately involved in the onset of a variety of diseases. It is becoming increasingly evident that the composition of commensal microflora in the oral cavity is closely connected to oral diseases, such as periodontal disease, and systemic diseases, such as inflammatory bowel disease. Next-generation sequencing techniques are used as a method to examine changes in bacterial flora, but additional analytical methods to assess bacterial flora are needed to understand bacterial activity in more detail. Read More

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Surfactant protein D: A useful biomarker for distinguishing COVID-19 pneumonia from COVID-19 pneumonia-like diseases.

Health Sci Rep 2022 May 25;5(3):e622. Epub 2022 Apr 25.

Department of Respiratory Medicine Tokyo Medical University Hospital Shinjuku-ku Tokyo Japan.

Introduction: Computed tomography is useful for the diagnosis of coronavirus disease (COVID-19) pneumonia. However, many types of interstitial lung diseases and even bacterial pneumonia can show abnormal chest shadows that are indistinguishable from those observed in COVID-19 pneumonia. Thus, it is necessary to identify useful biomarkers that can efficiently distinguish COVID-19 pneumonia from COVID-19 pneumonia-like diseases. Read More

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Rapid enlargement of pulmonary benign metastasizing leiomyoma with fluid-containing cystic change: a case report.

Surg Case Rep 2022 May 5;8(1):84. Epub 2022 May 5.

Department of Thoracic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease that can occur in women with a history of uterine leiomyoma. Despite its benign histological features, like a malignancy, leiomyomas can on rare occasion spread to the lung. Typically, PBML presents with asymptomatic multiple solid lung nodules with slow tumor progression, following hysterectomy. Read More

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Assessment of therapeutic outcome and role of reirradiation in patients with radiation-induced glioma.

Radiat Oncol 2022 May 3;17(1):85. Epub 2022 May 3.

Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Background: We sought to clarify the optimal follow-up, therapeutic strategy, especially the role of reirradiation, and the diagnostic impact of isocitrate dehydrogenase (IDH) 1 and 2 mutation status in patients with radiation-induced glioma (RIG).

Methods: We retrospectively reviewed the clinical characteristics and treatment outcomes of 11 patients with high-grade glioma who satisfied Cahan's criteria for RIG in our database during 2001-2021. IDH 1/2 mutations were analyzed by Sanger sequencing and/or pyrosequencing. Read More

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Rare evolution of -mutated chronic neutrophilic leukemia to t(4;12)(q12;p13) acute myeloid leukemia with mutation.

Leuk Res Rep 2022 12;17:100311. Epub 2022 Apr 12.

Division of Hematology, Department of Medicine, Saiseikai Central Hospital, Tokyo, Japan.

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disease accompanied by mutations in . Here, we present a patient with CNL who developed to acute myeloid leukemia (AML) at the same time that a t(4;12)(q12;p13) translocation appeared. The uniqueness of this cytogenetic abnormality led us to delineate the molecular aberrations relevant for clonal evolution. Read More

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Committee report: Questionnaire survey on the treatment of COVID-19 in patients receiving dialysis therapy.

Ren Replace Ther 2022 25;8(1):18. Epub 2022 Apr 25.

Infection Control Committee, The Japanese Society for Dialysis Therapy, Tokyo, Japan.

Background: Patients with coronavirus disease 2019 (COVID-19) who receive dialysis therapy develop more severe disease and have a poorer prognosis than patients who do not. Although various data on the treatment of patients not receiving dialysis therapy have been reported, clinical practice for patients on dialysis is challenging as data is limited. The Infection Control Committee of the Japanese Society for Dialysis Therapy decided to clarify the status of treatment in COVID-19 patients on dialysis. Read More

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Nafamostat mesylate monotherapy in patients with moderate COVID-19 : A single-center retrospective study.

Jpn J Infect Dis 2022 Apr 28. Epub 2022 Apr 28.

Department of Pulmonary Medicine, National Hospital Organization Kanagawa Hospital, Japan.

Coronavirus disease 2019 (COVID-19) expanded dramatically all over the world. Nafamostat mesylate inhibits the intracellular entry of novel severe acute respiratory syndrome coronavirus 2 and it has been thought as the therapeutic potential of treatment for patients with COVID-19. In the present study, patients with moderate COVID-19 who were admitted to our hospital were retrospectively analyzed. Read More

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[Metabolism-dependent Vascular Pathophysiology in Adult Diseases].

Yakugaku Zasshi 2022 ;142(5):465-471

Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University.

In adult diseases, chronic inflammation-related angiopathy is the main pathological condition of organ disorders such as arteriosclerosis, chronic kidney disease, and non-alcoholic steatohepatitis (NASH). Macrophages play an important role in chronic inflammation. For example, macrophage foaming is important for atherosclerosis development. Read More

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Blood cell and marrow changes in patients with Kikuchi disease.

Haematologica 2022 Apr 28. Epub 2022 Apr 28.

Department of Otolaryngology, National Taiwan University Hospital, Taipei.

Not available. Read More

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Author Correction: Kikuchi-Fujimoto disease in the Eastern Mediterranean zone.

Sci Rep 2022 Apr 28;12(1):6954. Epub 2022 Apr 28.

Department of General Surgery and Urology, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid, Jordan.

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Health-Related Quality of Life Evaluation Using the Short Form-36 in Patients With Human T-Lymphotropic Virus Type 1-Associated Myelopathy.

Front Med (Lausanne) 2022 11;9:879379. Epub 2022 Apr 11.

Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan.

Background: Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) is a neuroinflammatory disease, causing various neurological symptoms, including motor, sensory, and bladder and bowel dysfunctions. This study was designed to reveal the impact of HAM and related symptoms on health-related quality of life (HRQoL).

Methods: We analyzed the Short Form-36 (SF-36) and clinical data of 538 patients with HAM registered in the HAM-net, a nationwide patient registry for HAM in Japan. Read More

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Oncological outcomes of dose reductions in cisplatin due to renal dysfunction for patients with metastatic urothelial carcinoma.

BJUI Compass 2021 Sep 9;2(5):322-330. Epub 2021 Mar 9.

Department of Urology Keio University School of Medicine Tokyo Japan.

Objective: To investigate whether dose reductions in cisplatin due to renal dysfunction were associated with worse clinical outcomes in metastatic urothelial carcinoma (UC) patients.

Patients And Methods: One hundred and fifty one metastatic UC patients who received first-line gemcitabine plus cisplatin (GC) salvage chemotherapy without a previous history of peri-surgical chemotherapy were included in this retrospective study. Patients with endogenous creatinine clearance of 60 mL/min or more were treated with a full dose of cisplatin, while those with 45-59 and 30-44 mL/min were treated with 75% and 50% doses, respectively. Read More

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September 2021

Clinical manifestations of hospitalized influenza patients without risk factors: A prospective multicenter cohort study in Japan via internet surveillance.

J Infect Chemother 2022 Jul 20;28(7):853-858. Epub 2022 Apr 20.

Division for Development of Anti-infective Agents, Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, 6-45-1, Kunimi, Aoba-ku, Sendai, 981-8551, Japan.

Introduction: Influenza remains a clinically heavy burden worldwide. It is well known that some populations are at high risk of complications from influenza, whereas, even previously healthy people might suffer from severe influenza. The objective of this study was to clarify clinical manifestations of hospitalized patients without risk factors infected with influenza. Read More

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Metabolic Alteration Analysis of Steroid Hormones in Niemann-Pick Disease Type C Model Cell Using Liquid Chromatography/Tandem Mass Spectrometry.

Int J Mol Sci 2022 Apr 18;23(8). Epub 2022 Apr 18.

Faculty of Pharmaceutical Sciences, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

Niemann-Pick disease type C (NPC) is an autosomal recessive disease caused by a functional deficiency of cholesterol-transporting proteins in lysosomes, and exhibits various clinical symptoms. Since mitochondrial dysfunction in NPC has recently been reported, cholesterol catabolism to steroid hormones may consequently be impaired. In this study, we developed a comprehensive steroid hormone analysis method using liquid chromatography/tandem mass spectrometry (LC-MS/MS) and applied it to analyze changes in steroid hormone concentrations in NPC model cells. Read More

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