4,256 results match your criteria Kikuchi Disease


About a rare disease misdiagnosed as malignant lymphoma or tuberculosis: Kikuchi-Fujimoto's disease.

Pan Afr Med J 2018 3;31:77. Epub 2018 Oct 3.

ENT Department, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.

Kikuchi-Fujimoto's disease KFD is a rare and benign cause of cervical lymphadenopathy. It is an anatomoclinical entity of unknown etiology. The confirmation of the diagnosis is always provided by histological lymph node study. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.77.16569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457726PMC
October 2018

Detecting geriatric needs in older patients with breast cancer through use of a brief geriatric screening tool.

J Geriatr Oncol 2019 Apr 17. Epub 2019 Apr 17.

Duke University Medical Center, Durham, NC, United States of America. Electronic address:

Introduction: Identification of geriatric syndromes is important for determining functional age and optimizing care for people with cancer. Based on administration of a geriatric screening tool, we aimed to describe needed resources for geriatric syndromes, including lack of social support, depressed mood, deficits in instrumental and activities of daily living (IADL/ADL), falls, nutritional issues, polypharmacy, ability to pay for medications, and memory deficits, in a population of patients with breast cancer.

Methods: Consecutive medical oncology patients with breast cancer age 65 years and older, seen at a tertiary care center, completed a screening tool, adapted from Overcash 2006, consisting of a nurse-administered memory assessment and a one-page, self-administered questionnaire. Read More

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http://dx.doi.org/10.1016/j.jgo.2019.04.010DOI Listing

Cinacalcet corrects biased allosteric modulation of CaSR by AHH autoantibody.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Endocrinology and Nephrology, The University of Tokyo School of Medicine, Tokyo, Japan.

Biased agonism is a paradigm that may explain the selective activation of a signaling pathway via a GPCR that activates multiple signals. The autoantibody-induced inactivation of the calcium-sensing receptor (CaSR) causes acquired hypocalciuric hypercalcemia (AHH). Here, we describe an instructive case of AHH in which severe hypercalcemia was accompanied by an increased CaSR antibody titer. Read More

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https://insight.jci.org/articles/view/126449
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http://dx.doi.org/10.1172/jci.insight.126449DOI Listing
April 2019
2 Reads

Management of adverse events related to endoscopic resection of upper gastrointestinal neoplasms: Review of the literature and recommendations from experts.

Dig Endosc 2019 Apr;31 Suppl 1:4-20

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Prevention therapy is recommended for lesions >1/2 of the esophageal circumference. Locoregional steroid injection is recommended for lesions >1/2-3/4 of the esophageal circumference and oral steroids are recommended for lesions >1/2 of the subtotal circumference. For lesions of the entire circumference, oral steroid combined with injection steroid is considered. Read More

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http://dx.doi.org/10.1111/den.13388DOI Listing
April 2019
2 Reads

Kikuchi-Fujimoto Disease: An Atypical Presentation of a Rare Disease.

Cureus 2019 Feb 1;11(2):e3999. Epub 2019 Feb 1.

Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Kikuchi-Fujimoto disease (KFD), or necrotizing histiocytic lymphadenitis, is a rare cause of lymphadenopathy and fever. Although the clinical course is usually benign, KFD is often mistaken for malignancy or infection. Recognition of typical and atypical cases of KFD is necessary to avoid unnecessary interventions. Read More

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http://dx.doi.org/10.7759/cureus.3999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445562PMC
February 2019
2 Reads

Stage-specific transcriptome of Bursaphelenchus xylophilus reveals temporal regulation of effector genes and roles of the dauer-like stages in the lifecycle.

Sci Rep 2019 Apr 15;9(1):6080. Epub 2019 Apr 15.

Division of Parasitology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.

The pine wood nematode Bursaphelenchus xylophilus is the causal agent of pine wilt disease, one of the most devastating forest diseases in East Asian and West European countries. The lifecycle of B. xylophilus includes four propagative larval stages and gonochoristic adults which are involved in the pathogenicity, and two stages of dispersal larvae involved in the spread of the disease. Read More

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http://dx.doi.org/10.1038/s41598-019-42570-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465311PMC

Relapsing Kikuchi-Fujimoto Disease Requiring Prolonged Steroid Therapy.

Case Rep Emerg Med 2019 7;2019:6405687. Epub 2019 Mar 7.

Department of General Internal Medicine & Emergency Medicine, Hirslanden, Klinik Im Park, Seestrasse 220, 8027 Zurich, Switzerland.

We report the case of a 26-year-old woman with an eight-week history of painfully enlarged cervical lymph nodes, recurrent headache, and malaise. Her medical history was unremarkable. The physical examination showed multiple enlarged cervical lymph nodes. Read More

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https://www.hindawi.com/journals/criem/2019/6405687/
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http://dx.doi.org/10.1155/2019/6405687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431476PMC
March 2019
1 Read

Longitudinal changes in F-THK5351 PET in corticobasal syndrome.

Eur J Neurol 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Corticobasal syndrome (CBS) is pathologically characterized by tau deposits in neuronal and glial cells and by reactive astrogliosis. In several neurodegenerative disorders, F-THK5351 has been observed to bind to reactive astrocytes expressing monoamine oxidase B (MAO-B). In this study, we aimed to investigate the progression of disease-related pathology in the brains of patients with CBS using PET with F-THK5351. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13966
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http://dx.doi.org/10.1111/ene.13966DOI Listing
April 2019
2 Reads
4.055 Impact Factor

Gene Polymorphism of Tacrolimus-Metabolizing Enzymes Associated With Impaired Absorption of Tacrolimus Following Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report.

Transplant Proc 2019 Apr 26;51(3):998-1001. Epub 2019 Jan 26.

Department of Hematology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

Objective: To elucidate the mechanisms by which orally administered tacrolimus was not absorbed in a patient following allogeneic hematopoietic stem cell transplantation.

Clinical Course: A 17-year-old girl with acute myeloid leukemia underwent HLA-haploidentical peripheral blood stem cell transplantation following fludarabine, busulfan, and total-body irradiation. Graft-vs-host disease prophylaxis was post-transplant cyclophosphamide, followed by intravenous tacrolimus and mycophenolate mofetil. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.061DOI Listing
April 2019
2 Reads

Impact of Total Antithrombotic Effect on Bleeding Complications in Patients Receiving Multiple Antithrombotic Agents.

Circ J 2019 Apr 11. Epub 2019 Apr 11.

Division of Cardiology, Yokohama City University Medical Center.

Background: Few reports have evaluated the total antithrombotic effect of multiple antithrombotic agents. Methods and Results: Thrombus formation was evaluated with the Total Thrombus-formation Analysis System (T-TAS) using 2 types of microchips in 145 patients with stable coronary artery disease receiving oral anticoagulants plus single- or dual-antiplatelet therapy. The PL-chip coated with collagen is designed for analysis of the platelet thrombus formation process under shear stress condition (18 µL/min). Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1236DOI Listing
April 2019
1 Read

Tumor-targeting Salmonella typhimurium A1-R overcomes nab-paclitaxel resistance in a cervical cancer PDOX mouse model.

Arch Gynecol Obstet 2019 Apr 5. Epub 2019 Apr 5.

AntiCancer Inc., San Diego, CA, USA.

Purpose: Cervical cancer is a recalcitrant disease. To help overcome this problem, we previously established a patient-derived orthotopic xenograft (PDOX) model of cervical cancer. In the previous study, we found the tumor to be resistant to nab-paclitaxal (nab-PTX). Read More

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http://dx.doi.org/10.1007/s00404-019-05147-3DOI Listing
April 2019
4 Reads

Recurrent de novo MAPK8IP3 variants cause neurological phenotypes.

Ann Neurol 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

JIP3, encoded by MAPK8IP3, is an adaptor protein of the kinesin-1 complex and essential for axonal transport in neurons. However, an association between MAPK8IP3 variants and human disease has not been established. We identified five individuals from four families with recurrent de novo variants c. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25481
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http://dx.doi.org/10.1002/ana.25481DOI Listing
April 2019
3 Reads

Differentiation Between Malignant and Benign Lymph Nodes: Role of Superb Microvascular Imaging in the Evaluation of Cervical Lymph Nodes.

J Ultrasound Med 2019 Apr 3. Epub 2019 Apr 3.

Department of Radiology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Objectives: This study aimed to assess the value of Superb Microvascular Imaging (SMI; Canon Medical Systems, Otawara, Japan) for distinguishing between benign and malignant cervical lymph nodes (LNs) and to compare SMI with power Doppler ultrasound (PDUS).

Methods: Power Doppler ultrasound and SMI examinations were performed for patients' cervical LNs. The distribution of feeding vessels, number, and appearance of internal vessels were analyzed by 2 readers, and the results of PDUS and SMI were compared. Read More

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http://dx.doi.org/10.1002/jum.15010DOI Listing
April 2019
2 Reads

Hemodialysis product and hip fracture in hemodialysis patients: A nationwide cohort study in Japan.

Ther Apher Dial 2019 Apr 2. Epub 2019 Apr 2.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.

Some have raised concerns that longer and more frequent hemodialysis would be associated with bone fractures due to excess phosphate removal. We examined the effects of Hemodialysis Product on hip fracture incidence among Japanese hemodialysis patients using registry data of the Japanese Society of Dialysis Therapy. During a one-year study period, 1,411 hip fractures occurred among 135,984 patients. Read More

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http://dx.doi.org/10.1111/1744-9987.12807DOI Listing
April 2019
5 Reads

Validation of a diagnostic score model for the prediction of Legionella pneumophila pneumonia.

J Infect Chemother 2019 Mar 29. Epub 2019 Mar 29.

Development of Anti-Infective Agents, Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Japan.

Background: Community-acquired pneumonia (CAP) due to Legionella has a high mortality rate in patients who do not receive adequate antibiotic therapy. In a previous study, we developed a simple Legionella Score to distinguish patients with Legionella and non-Legionella pneumonia based on clinical information at diagnosis. In the present study, we validated this Legionella Score for the presumptive diagnosis of Legionella CAP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1341321X193007
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http://dx.doi.org/10.1016/j.jiac.2019.03.009DOI Listing
March 2019
14 Reads

Appropriate number of biliary biopsies and endoscopic retrograde cholangiopancreatography sessions for diagnosing biliary tract cancer.

World J Gastrointest Endosc 2019 Mar;11(3):231-238

Department of Gastroenterology, Fukushima Medical University, School of Medicine, Fukushima 960-1247, Japan.

Background: Biliary ductal cancer (BDC) is a lethal disease; however, diagnosing BDC is challenging. Biliary biopsies are performed to pathologically diagnose BDC, but the appropriate parameters for biliary biopsy [number of biliary biopsies, number of endoscopic retrograde cholangiopancreatography (ERCP) sessions, .] are unknown. Read More

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http://dx.doi.org/10.4253/wjge.v11.i3.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425282PMC
March 2019
1 Read

A case of nivolumab-associated colitis, which relapsed after mucosal healing and was then successfully treated with mesalazine.

Immunol Med 2019 Mar 27:1-6. Epub 2019 Mar 27.

a Department of Gastroenterology and Hematology, School of Medicine , Hirosaki University , Hirosaki , Japan.

Currently, the number of patients treated with immune-checkpoint inhibitor involving nivolumab is increasing. Nevertheless, it causes various immune-related adverse events (irAEs). Here, we report the case of a patient who underwent long-term follow-up after suffering from nivolumab-associated colitis. Read More

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http://dx.doi.org/10.1080/25785826.2019.1580477DOI Listing
March 2019
1 Read

Cervical necrotic lymphadenopathy: a diagnostic tree analysis model based on CT and clinical findings.

Eur Radiol 2019 Mar 26. Epub 2019 Mar 26.

Department of Radiology, Korea University Hospital, Seoul, South Korea.

Objectives: To establish a diagnostic tree analysis (DTA) model based on computed tomography (CT) findings and clinical information for differential diagnosis of cervical necrotic lymphadenopathy, especially in regions where tuberculous lymphadenitis and Kikuchi disease are common.

Methods: A total of 290 patients (147 men and 143 women; mean age (years), 46.2 ± 19. Read More

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http://dx.doi.org/10.1007/s00330-019-06155-2DOI Listing

Future projection of cancer patients with cardiovascular disease in Japan by the year 2039: a pilot study.

Int J Clin Oncol 2019 Mar 22. Epub 2019 Mar 22.

Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background: The number of cancer patients in Japan is estimated to rise to 3.5 million by 2025. The disease burden may be further complicated by comorbidities caused by cardiovascular disease (CVD). Read More

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http://link.springer.com/10.1007/s10147-019-01426-w
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http://dx.doi.org/10.1007/s10147-019-01426-wDOI Listing
March 2019
5 Reads

Droplet Digital PCR Detection of the Erythropoietin Transgene from Horse Plasma and Urine for Gene-Doping Control.

Genes (Basel) 2019 Mar 21;10(3). Epub 2019 Mar 21.

Genetic Analysis Department, Laboratory of Racing Chemistry, 1731-2 Tsurutamachi, Utsunomiya, Tochigi 320-0851, Japan.

Indiscriminate genetic manipulation to improve athletic ability is a major threat to human sports and the horseracing industry, in which methods involving gene-doping, such as transgenesis, should be prohibited to ensure fairness. Therefore, development of methods to detect indiscriminate genetic manipulation are urgently needed. Here, we developed a highly sensitive method to detect horse erythropoietin () transgenes using droplet digital PCR (ddPCR). Read More

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http://dx.doi.org/10.3390/genes10030243DOI Listing

Kikuchi-Fujimoto Disease and Prognostic Implications.

Head Neck Pathol 2019 Mar 19. Epub 2019 Mar 19.

Department of Otolaryngology, Princess Royal Hospital, Telford, Shropshire, UK.

Kikuchi-Fujimoto disease (KFD) is a rare cause of lymphadenitis seen mostly in Asian populations (Kikuchi in Nippon Ketsueki Gakkai Zasshi 35:379-80, 1972). First described in 1972, KFD is a benign and self-limiting disease characterised by lymphadenopathy, mild fever, fatigue, and leukopenia (Fujimoto in Naika 30:920-7, 1972; Lin et al. in Otolaryngol Head Neck Surg 128(5): 650-3, 2003). Read More

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http://dx.doi.org/10.1007/s12105-019-01026-0DOI Listing
March 2019
1 Read

Case report: new development of fibrosing interstitial lung disease triggered by HIV-related pneumocystis pneumonia.

BMC Pulm Med 2019 Mar 18;19(1):65. Epub 2019 Mar 18.

AIDS Clinical Center, National Center of Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: Fibrosing interstitial lung disease is the poor prognostic non-infectious lung disease by unknown etiology. Here, we present one case developing interstitial pneumonia with fibrosis after treatment of pneumocystis pneumonia (PCP) in newly diagnosed HIV-1 infected case.

Case Presentation: A previously healthy 63-year old male was referred to our institute because of protracted dyspnea on effort in 2 weeks after pneumocystis pneumonia treatment. Read More

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http://dx.doi.org/10.1186/s12890-019-0831-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423812PMC
March 2019
3 Reads

Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors.

BMC Infect Dis 2019 Mar 18;19(1):263. Epub 2019 Mar 18.

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, 757 Ichibancho, Asahimachi-dori, Chuo Ward, Niigata City, 951-8510, Japan.

Background: Mycobacterium avium complex lung disease (MAC-LD) can deteriorate rapidly to become fatal. Reported poor prognostic factors include radiographic findings, undernutrition, anemia and high inflammation test values. However, the association of these prognostic factors with the pathophysiology of the disease remains unknown. Read More

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http://dx.doi.org/10.1186/s12879-019-3888-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423821PMC
March 2019
1 Read

Restoration of periventricular vasculature after direct bypass for moyamoya disease: intra-individual comparison.

Acta Neurochir (Wien) 2019 Mar 18. Epub 2019 Mar 18.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: While periventricular anastomosis, a unique abnormal vasculature in moyamoya disease, has been studied in relation to intracranial hemorrhage, no study has addressed its change after bypass surgery. The authors sought to test whether direct bypass surgery could restore normal periventricular vasculature.

Methods: Patients who had undergone direct bypass surgery for moyamoya disease at a single institution were eligible for the study. Read More

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http://dx.doi.org/10.1007/s00701-019-03866-9DOI Listing
March 2019
1 Read
1.788 Impact Factor

Molecular Phylogeny of Mobatviruses () in Myanmar and Vietnam.

Viruses 2019 Mar 7;11(3). Epub 2019 Mar 7.

Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.

The discovery of highly divergent lineages of hantaviruses (family ) in shrews, moles, and bats of multiple species raises the possibility that non-rodent hosts may have played a significant role in their evolutionary history. To further investigate this prospect, total RNA was extracted from RNAlater-preserved lung tissues of 277 bats (representing five families, 14 genera and 40 species), captured in Myanmar and Vietnam during 2013⁻2016. Hantavirus RNA was detected in two of 15 black-bearded tomb bats () and two of 26 Pomona roundleaf bats () in Myanmar, and in three of six ashy leaf-nosed bats () in Vietnam. Read More

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https://www.mdpi.com/1999-4915/11/3/228
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http://dx.doi.org/10.3390/v11030228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466252PMC
March 2019
4 Reads
3.279 Impact Factor

Kikuchi-Fujimoto disease presenting as post-traumatic pyrexia of unknown origin.

Br J Hosp Med (Lond) 2019 Mar;80(3):170-171

Consultant Physician, Department of Medicine, South West Acute Hospital, Western Health and Social Care Trust, Enniskillen, Northern Ireland.

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http://www.magonlinelibrary.com/doi/10.12968/hmed.2019.80.3.
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http://dx.doi.org/10.12968/hmed.2019.80.3.170DOI Listing
March 2019
6 Reads

Kikuchi-Fujimoto Disease in an Iranian Woman; a Rare but Important Cause of Lymphadenopathy.

Arch Acad Emerg Med 2019 1;7(1):e3. Epub 2019 Jan 1.

Department of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Kikuchi-Fujimoto Disease (KFD), is a rare and self-limited condition of histiocytic necrotizing lymphadenitis, which typically presents as fever and lymphadenopathy. We describe a case of KFD in an Iranian woman. Due to low incidence and high importance, awareness of this disease is necessary for clinicians for early diagnosis and appropriate treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377216PMC
January 2019
1 Read

Rare diseases that mimic Systemic Lupus Erythematosus (Lupus mimickers).

Joint Bone Spine 2019 Mar 26;86(2):165-171. Epub 2018 Oct 26.

Centre national de référence des maladies autoimmunes et systémiques rares Est Sud-Ouest (RESO)-LUPUS, 67000 Strasbourg, France; Service de rhumatologie, hôpitaux universitaires de Strasbourg, 67098 Strasbourg, France; Université de Strasbourg, Inserm UMR-S 1109, 67000 Strasbourg, France. Electronic address:

Several conditions have clinical and laboratory features that can mimic those present in Systemic Lupus Erythematosus (SLE). Some of these "SLE mimickers" are very common, such as rosacea which can be mistaken for the butterfly rash, while others such as Kikuchi disease, type-1 interferonopathies, Castleman's disease, prolidase deficiency, angioimmunoblastic T-cell lymphoma, Evans' syndrome in the context of primary immune deficiencies and the autoimmune lymphoproliferative syndrome are exceptionally uncommon. A proper diagnosis of SLE must therefore be based upon a complete medical history as well as on the adequate constellation of clinical or laboratory findings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183042
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http://dx.doi.org/10.1016/j.jbspin.2018.10.007DOI Listing
March 2019
10 Reads

Kikuchi-Fujimoto Disease in Michigan: A Rare Case Report and Review of the Literature.

Clin Med Insights Ear Nose Throat 2019 27;12:1179550619828680. Epub 2019 Feb 27.

Department of Otolaryngology/Head and Neck Surgery, McLaren Oakland Hospital, Pontiac, MI, USA.

Background: Kikuchi-Fujimoto Disease (KFD), also known as Histiocytic Necrotizing Lymphadenitis, is a rare cause of prolonged cervical lymphadenopathy in both the pediatric and adult populations. It was first reported in Japan in 1972, and since, this disease has been described worldwide, although most cases have been reported in Asia. The etiology of KFD is not fully understood, although there are 2 theories that are described in detail in this review. Read More

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http://dx.doi.org/10.1177/1179550619828680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393831PMC
February 2019
2 Reads

Clinical characteristics of hospitalized heart failure patients with preserved, mid-range, and reduced ejection fractions in Japan.

ESC Heart Fail 2019 Mar 3. Epub 2019 Mar 3.

Department of Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Aims: There are regional differences in the patient characteristics, management, and outcomes of hospitalized patients with heart failure (HF). The aim of this study was to evaluate the clinical characteristics and outcomes of Japanese patients who are hospitalized with HF on the basis of the left ventricular ejection fraction (LVEF) stratum.

Methods And Results: We retrospectively conducted a multicentre cohort study of 1245 hospitalized patients with decompensated HF between 2013 and 2014. Read More

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http://doi.wiley.com/10.1002/ehf2.12418
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http://dx.doi.org/10.1002/ehf2.12418DOI Listing
March 2019
14 Reads

Pneumocystis pneumonia in HIV-1-infected patients.

Respir Investig 2019 Feb 26. Epub 2019 Feb 26.

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachidori, Chuoku, Niigata 951-8510, Japan. Electronic address:

Pneumocystis pneumonia (PCP) is an opportunistic disease that mainly affects patients with a deficiency of cell-mediated immunity, especially acquired immunodeficiency syndrome (AIDS). The incidence of PCP in these patients has declined substantially owing to the widespread use of antiretroviral therapy and PCP prophylaxis. However, PCP is still a major AIDS-related opportunistic infection, particularly in patients with advanced immunosuppression in whom human immunodeficiency virus type 1 (HIV-1) infection remains undiagnosed or untreated. Read More

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http://dx.doi.org/10.1016/j.resinv.2019.01.009DOI Listing
February 2019
2 Reads

Genotype-Clinical Correlations in Polycystic Kidney Disease with No Apparent Family History.

Am J Nephrol 2019 28;49(3):233-240. Epub 2019 Feb 28.

Nephrology Center, Toranomon Hospital, Tokyo, Japan.

Background: Genetic characteristics of polycystic kidney disease (PKD) patients without apparent family history were reported to be different from those with a positive family history. However, the clinical course of PKD patients with no apparent family history is not well documented in the literature.

Methods: We evaluated the relationship between genotype and the clinical course of 62 PKD patients with no apparent family history. Read More

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http://dx.doi.org/10.1159/000497444DOI Listing
February 2019
1 Read

Elemental Diet Regulates Intestinal Permeability and Antibody Production in Indomethacin-Induced Intestinal Injury Rats.

J Nutr Sci Vitaminol (Tokyo) 2019 ;65(1):31-37

Department of Food and Health Sciences, Faculty of Environmental & Symbiotic Sciences, Prefectural University of Kumamoto.

Crohn's disease is a type of inflammatory bowel disease of unknown etiology. Administration of indomethacin (Indo) to rats induces acute mucosal lesions similar to those observed in Crohn's disease patients, but the damage can be prevented by feeding the animals an elemental diet (ED). In this study, we examined changes in intestinal macroscopic appearance, permeability, and immunoglobulin production after administration of Indo to male Sprague-Dawley rats fed normal lab chow or an ED. Read More

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http://dx.doi.org/10.3177/jnsv.65.31DOI Listing
January 2019
2 Reads

Optimal use of anthracycline-free perioperative chemotherapy in HER2-positive breast cancer patients.

Int J Clin Oncol 2019 Feb 27. Epub 2019 Feb 27.

Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku, Tokyo, 160-8582, Japan.

Purpose: In adjuvant settings of human epidermal growth factor receptor 2 (HER2)-positive breast cancer, anthracycline-based chemotherapy followed by taxane and trastuzumab is a standard regimen. Recent studies have reported the use of anthracycline-free adjuvant chemotherapy in selected HER2-positive breast cancer patients. We conducted a single-center retrospective study to identify the characteristics of HER2-positive breast cancer patients for whom anthracyclines can be safely omitted. Read More

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http://dx.doi.org/10.1007/s10147-019-01420-2DOI Listing
February 2019
3 Reads

An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes.

Sci Rep 2019 Feb 22;9(1):2587. Epub 2019 Feb 22.

Graduate School of Engineering, Muroran Institute of Technology, Muroran, Hokkaido, Japan.

Protein aggregation is the principal component of numerous protein misfolding pathologies termed proteinopathies, such as Alzheimer's disease, Parkinson's disease, prion disease, and AA amyloidosis with unmet treatment needs. Protein aggregation inhibitors have great potential for the prevention and treatment of proteinopathies. Here we report the development of an automated real-time microliter-scale high throughput screening (MSHTS) system for amyloid aggregation inhibitors using quantum-dot nanoprobes. Read More

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http://dx.doi.org/10.1038/s41598-019-38958-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384891PMC
February 2019
6 Reads

Iron treatment inhibits Aβ42 deposition in vivo and reduces Aβ42/Aβ40 ratio.

Biochem Biophys Res Commun 2019 May 18;512(4):653-658. Epub 2019 Feb 18.

Department of Neuroscience, School of Pharmacy, Iwate Medical University, Yahaba, Japan; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. Electronic address:

Alzheimer's disease (AD) is characterized by the formation of extracellular amyloid plaques containing the amyloid β-protein (Aβ) within the parenchyma of the brain. Aβ42, which is 42 amino acids in length, is considered to be the key pathogenic factor in AD. Iron deposition is found abundantly in the amyloid plaques of AD patients; however, whether iron intake exacerbates amyloid deposition in vivo is unknown. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.119DOI Listing
May 2019
3 Reads

A Pilot Study of Vaccine Therapy with Multiple Glioma Oncoantigen/Glioma Angiogenesis-Associated Antigen Peptides for Patients with Recurrent/Progressive High-Grade Glioma.

J Clin Med 2019 Feb 20;8(2). Epub 2019 Feb 20.

Department of Neurosurgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8587, Japan.

High-grade gliomas (HGGs) carry a dismal prognosis despite current treatments. We previously confirmed the safety and immunogenicity of a vaccine treatment targeting tumor angiogenesis with synthetic peptides, for vascular endothelial growth factor receptor (VEGFR) epitopes in recurrent HGG patients. In this study, we evaluated a novel vaccine therapy targeting not only tumor vasculature but also tumor cells, using multiple glioma oncoantigen (GOA)/glioma angiogenesis-associated antigen (GAAA) peptides in HLA-A2402+ recurrent/progressive HGG patients. Read More

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http://dx.doi.org/10.3390/jcm8020263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406695PMC
February 2019
2 Reads

Retrospective efficacy analysis of immune checkpoint inhibitors in patients with EGFR-mutated non-small cell lung cancer.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background: Treatment with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) leads to initial response in most patients with EGFR-mutated non-small cell lung cancer (NSCLC). In contrast, little is known of the subpopulation of patients with NSCLC with EGFR mutations who exhibit clinical outcomes that require treatment with immune checkpoint inhibitors (ICIs). Therefore, to identify eligible cases to treat with ICIs, we retrospectively analyzed the correlation between clinical features and the efficacy of ICIs in patients with EGFR mutations. Read More

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http://dx.doi.org/10.1002/cam4.2037DOI Listing
February 2019
1 Read

Predilution online hemodiafiltration is associated with improved survival compared with hemodialysis.

Kidney Int 2019 Apr 16;95(4):929-938. Epub 2019 Feb 16.

Renal Data Registry Committee, Japanese Society for Dialysis Therapy, Tokyo, Japan; Yabuki Hospital, Yamagata, Japan.

On-line hemodiafiltration is an increasingly common alternative to chronic hemodialysis in some countries, based on the results of randomized controlled trials of post-dilution on-line hemodiafiltration. There are now more than 60,000 patients treated with on-line hemodialfiltration in Japan, over 95% of whom use predilution on-line hemodiafiltration; however, large-scale data on clinical outcomes with this modality are lacking. We created a propensity-matched cohort of 5,000 pairs of patients treated with conventional hemodialysis or predilution on-line hemodiafiltration, using the Japanese Society for Dialysis Therapy Renal Data Registry database from December 31, 2012 to December 31, 2013. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.036DOI Listing
April 2019
1 Read

Kikuchi-Fujimoto Disease Associated with Sjögren's Syndrome: A Case Report.

Eur J Case Rep Intern Med 2018 25;5(5):000856. Epub 2018 May 25.

Rheumatology Department, Hamad Medical Corporation, Doha, Qatar.

Kikuchi-Fujimoto disease (KFD) or Kikuchi histiocytic necrotizing lymphadenitis, is an extremely rare, benign and self-limiting disease which can be confused with lymphoma and sometime with infections such as tuberculosis. It has also been infrequently reported in association with autoimmune diseases. KFD shares sex and age predisposition as well as histological features with systemic lupus erythematosus. Read More

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http://dx.doi.org/10.12890/2018_000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346929PMC
May 2018
8 Reads

Review of the efficacy of AST-120 (KREMEZIN) on renal function in chronic kidney disease patients.

Ren Fail 2019 Nov;41(1):47-56

a Kureha Corporation , Tokyo , Japan.

AST-120 (KREMEZIN®) consists of oral, spherical carbon particles that adsorb uremic toxins and their precursors within the gastrointestinal tract, allowing them to be excreted in the feces. Uremic toxins such as indoxyl sulfate and p-cresyl sulfate are abundant in the blood of chronic kidney disease (CKD) patients and are related to the progression of both CKD and cardiovascular disease. AST-120 was approved in Japan in 1991 followed by Korea (2004), Taiwan (2007) and the Philippines (2010) for treating uremic symptoms and prolonging the time to initiation of dialysis in patients with progressive CKD. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374968PMC
November 2019
8 Reads

Atypical temporal-scale-specific fractal changes in Alzheimer's disease EEG and their relevance to cognitive decline.

Cogn Neurodyn 2019 Feb 8;13(1):1-11. Epub 2018 Oct 8.

4Department of Neuropsychiatry, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji, Yoshida, Fukui, 910-1193 Japan.

Recent advances in nonlinear analytic methods for electroencephalography have clarified the reduced complexity of spatiotemporal dynamics in brain activity observed in Alzheimer's disease (AD). However, there are far fewer studies exploring temporal scale dependent fractal properties in AD, despite the importance of studying the dynamics of brain activity within physiologically relevant frequency ranges. Higuchi's fractal dimension is a widely used index for evaluating fractality in brain activity, but temporal-scale-specific characteristics are lost due to its requirement of averaging over the entire range of temporal scales. Read More

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http://dx.doi.org/10.1007/s11571-018-9509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339858PMC
February 2019
2 Reads

[Bacteriocidal effects of introducing copper products on highly touched areas in hematology ward].

Rinsho Ketsueki 2019;60(1):3-6

Division of Hematology, Department of Medicine, Keio University School of Medicine.

Nosocomial infection via the hospital environment is a serious problem, and highly touched surfaces are the main route of transmission. Copper has been reported to possess bacteriocidal effects, and the introduction of copper-impregnated products is receiving attention as a potential component of hospital infection control. In this study, copper-impregnated door handles as highly touched areas were introduced in a hematology ward, and their bacteriocidal effects were evaluated in comparison with conventional products. Read More

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http://dx.doi.org/10.11406/rinketsu.60.3DOI Listing
January 2019
2 Reads

Feasibility and safety of jailed-pressure wire technique using durable optical fiber pressure wire for intervention of coronary bifurcation lesions.

Catheter Cardiovasc Interv 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiovascular Medicine, Gifu Heart Center, Gifu, Japan.

Objectives: The objective was to evaluate the safety, feasibility, and accuracy of the jailed-pressure wire technique using a durable optical fiber-based pressure wire with high-pressure dilatation using a non-compliant balloon after main vessel stenting.

Background: Fractional flow reserve (FFR) information can help interventionists determine whether they should treat a jailed-side branch (SB). However, re-crossing a pressure wire into a jailed-SB is sometimes technically difficult. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccd.28106
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http://dx.doi.org/10.1002/ccd.28106DOI Listing
February 2019
5 Reads

Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer.

Cancer Sci 2019 Apr 1;110(4):1431-1441. Epub 2019 Mar 1.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

The prognostic role of CD44v9, a variant isoform of CD44 and a new cell surface marker of cancer stem cells, remains unclear in bladder cancer (BC) patients. Furthermore, limited information is available on the functional role of sulfasalazine (SSZ), which could modulate the CD44v9-xCT system in order to enhance cisplatin (CDDP)-induced cytotoxicity and inhibit the metastatic potential of BC. CD44v9 protein expression was examined immunohistochemically in 63 muscle invasive BC (MIBC) patients who underwent radical cystectomy. Read More

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http://dx.doi.org/10.1111/cas.13960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447829PMC
April 2019
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A Catastrophic Case of Idiopathic Cholesterol Crystal Embolism with Multiple Lethal Complications: A Labyrinth Underneath the Diagnosis of Skin Ulcers in Chronic Kidney Disease Patients.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Japan.

A 66-year-old man was admitted to our hospital because of multiple refractory skin ulcers. Based on his severe systemic arterial calcification and severe calcium-phosphate imbalance due to severe kidney dysfunction, we initially considered calciphylaxis. However, a skin biopsy provided a diagnosis of cholesterol crystal embolization. Read More

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http://dx.doi.org/10.2169/internalmedicine.2378-18DOI Listing
February 2019
2 Reads

Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta-thalassemia.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of General Internal Medicine, Hiroshima University Hospital, Japan.

Acute chest syndrome (ACS), characterized by fever, respiratory symptoms, and new pulmonary infiltration, is a serious complication of sickle cell disease (SCD). Regardless of the etiology, the conventional treatment options for ACS include empirical antibiotic therapy, the administration of analgesics, and red cell transfusion. The indications and methods of red cell transfusion are critical. Read More

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http://dx.doi.org/10.2169/internalmedicine.1753-18DOI Listing
February 2019
4 Reads

Tumorous CD10 Is More Strongly Related to the Progression of Urothelial Carcinoma than Stromal CD10.

Anticancer Res 2019 Feb;39(2):635-640

Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.

Background/aim: CD10 function in urothelial carcinoma (UC) remains controversial. We previously reported that miR-21 in UC may be a prognostic marker for cancer progression. The aim of this study was to examine the clinicopathological significance of CD10 expression in UC and its relationship with miR-21 expression. Read More

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http://dx.doi.org/10.21873/anticanres.13157DOI Listing
February 2019
4 Reads

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study).

Ann Gastroenterol Surg 2019 Jan 11;3(1):96-103. Epub 2018 Oct 11.

Department of Gastroenterological Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

Aim: As a result of the difficulty in effective prevention of gastroesophageal reflux, no standard reconstruction procedure after proximal gastrectomy (PG) has yet been established. The double-flap technique (DFT), or Kamikawa procedure, is an antireflux reconstruction procedure in esophagogastrostomy. The efficacy of DFT has recently been reported in several studies. Read More

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http://dx.doi.org/10.1002/ags3.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345660PMC
January 2019
4 Reads