4,530 results match your criteria Kikuchi Disease


Oncomelania hupensis quadrasi: Snail intermediate host of Schistosoma japonicum in the Philippines.

Acta Trop 2020 May 29:105547. Epub 2020 May 29.

DNA Barcoding Laboratory, Institute of Biology, College of Science, University of the Philippines Diliman.

Oncomelania hupensis quadrasi is the snail intermediate host of Schistosoma japonicum in the Philippines. It was discovered by Dr. Marcos Tubangui in 1932 more than two decades after the discovery of the disease in the country in 1906. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2020.105547DOI Listing

[A case of acute pneumonia with prolonged false-positive results using an influenza test kit].

Nihon Ronen Igakkai Zasshi 2020 ;57(2):195-199

Department of Gastroenterology, Nagoya City West Medical Center.

Influenza (flu) is a prominent infectious disease that worsens the general prognosis of older adults. We herein report a case of a clinically odd and rare reaction on an instant diagnostic kit for influenza. An 81-year-old man with a fever and rhinorrhea consulted our hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3143/geriatrics.57.195DOI Listing
January 2020

Impact of age on clinical outcomes of antihypertensive therapy in patients with hypertension and coronary artery disease: A sub-analysis of the Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease.

J Clin Hypertens (Greenwich) 2020 May 31. Epub 2020 May 31.

Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan.

This study aimed to determine whether different systolic blood pressure (SBP) measurements achieved with antihypertensive therapy impact clinical outcomes by age in patients with hypertension and coronary artery disease (CAD). This post hoc analysis from the Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Heart Disease (HIJ-CREATE) trial included 2048 patients with hypertension and angiographically documented CAD. Participants were divided into three groups based on age at enrollment: middle-aged (<60 years, n = 570), pre-elderly (≥60-<70 years, n = 730), and elderly (≥70 years, n = 748). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jch.13891DOI Listing

Breast castleman disease.

Breast J 2020 May 29. Epub 2020 May 29.

Breast Oncology Center, Cancer Institute Hospital of JFCR, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tbj.13902DOI Listing

Increased body mass index above the upper normal limit is significantly associated with renal dysfunction among community-dwelling persons.

Int Urol Nephrol 2020 May 27. Epub 2020 May 27.

Department of Community Medicine, Ehime University Graduate School of Medicine, Shizukawa, Toon, Japan.

Purpose: Body mass index (BMI) is a simple index of weight-to-height that is commonly used to classify people as underweight, overweight or obesity, and high BMI has been clearly linked to increased risk of illness in adults. However, few studies have examined the significance of upper normal weight as a risk factor for the development of chronic kidney disease (CKD) in the general Japanese population.

Methods: We conducted a prospective cohort study designed as part of the Nomura study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-020-02501-2DOI Listing

Logopenic aphasia due to Lewy body disease dramatically improved with donepezil.

eNeurologicalSci 2020 Jun 8;19:100241. Epub 2020 May 8.

Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.

•Pathological basis of primary progressive aphasia is heterogeneous.•Logopenic primary progressive aphasia can precede dementia with Lewy bodies (DLB).•Cholinesterase inhibitor can improve logopenic aphasia with DLB. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ensci.2020.100241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235623PMC

Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication.

Tohoku J Exp Med 2020 05;251(1):27-30

Laboratory of Health and Sports Science, Division of Biomedical Engineering for Health and Welfare, Tohoku University Graduate School of Biomedical Engineering.

The number of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly increased, although the WHO declared a pandemic. However, drugs that function against SARS-CoV-2 have not been established. SARS-CoV-2 has been suggested to bind angiotensin-converting enzyme 2, the receptor of the SARS coronavirus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1620/tjem.251.27DOI Listing

Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular disease: reversibility of ischemic kidney.

Hypertens Res 2020 May 22. Epub 2020 May 22.

Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Renal artery stenosis causes kidney ischemia, reducing the size of the affected kidney, which eventually results in atrophy. Although renal atrophy is considered irreversible, resolution of the ischemia occasionally restores kidney size when the cause is renal artery stenosis. Angioplasty is effective in patients with nonatherosclerotic renovascular diseases (non-ARVDs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41440-020-0473-6DOI Listing

Clustering of Domain-Specific Sedentary Behaviors and Their Association With Physical Function Among Community-Dwelling Older Adults.

J Phys Act Health 2020 May 19:1-6. Epub 2020 May 19.

Background: The present study examined the cluster of domain-specific sedentary behaviors (SBs) and their associations with physical function among community-dwelling older adults to identify the target groups that require intervention for SBs.

Methods: A total of 314 older adults who participated in a population-based cross-sectional survey and an on-site functional assessment in Matsudo City in Chiba participated in this study. Participants were asked to report the daily average of 6 domain-specific SBs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1123/jpah.2019-0219DOI Listing

Impact of ineffective esophageal motility on chemical clearance in patients with gastroesophageal reflux symptoms.

Dis Esophagus 2020 May 15. Epub 2020 May 15.

Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Ineffective esophageal motility (IEM) is the most common manometric abnormality in gastroesophageal reflux disease (GERD). However, the impact of IEM on esophageal chemical clearance has not been fully investigated. This study aimed to determine the impact of IEM on esophageal chemical clearance in patients with GERD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/dote/doaa026DOI Listing

Low-Dose Erlotinib Treatment in Elderly or Frail Patients With EGFR Mutation-Positive Non-Small Cell Lung Cancer: A Multicenter Phase 2 Trial.

JAMA Oncol 2020 May 14:e201250. Epub 2020 May 14.

Department of Respiratory Medicine and Medical Oncology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.

Importance: Although the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for EGFR gene mutation-positive non-small cell lung cancer is well established, optimal dosing remains to be established, especially in elderly or frail patients.

Objective: To investigate the efficacy and safety of low-dose erlotinib in elderly or frail patients with EGFR mutation-positive non-small cell lung cancer.

Design, Setting, And Participants: Single-arm phase 2 trial with the Southwest Oncology Group (SWOG) 2-stage design that enrolled frail patients from 21 Japanese institutions after meeting the inclusion criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2020.1250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226294PMC

Hepatitis B virus reactivation in a myeloma patient with resolved infection who received daratumumab-containing salvage chemotherapy.

J Clin Exp Hematop 2020 May 13. Epub 2020 May 13.

Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 72-year-old female complaining of back pain was diagnosed with IgG-κ multiple myeloma. After osteosynthesis for fracture of the left femoral shaft due to myeloma, she received bortezomib, melphalan, and prednisolone as an initial regimen for multiple myeloma, but discontinued it after three courses due to progressive disease. The patient subsequently received lenalidomide and dexamethasone as a second-line regimen for 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3960/jslrt.19034DOI Listing

Diagnosis of the Patulous Eustachian Tube.

Ear Nose Throat J 2020 May 13:145561320925938. Epub 2020 May 13.

Sen-En Rifu Otological Surgery Center, Miyagi, Japan.

Objectives: To review the diagnosis of patulous Eustachian tube (PET) based on the diagnostic criteria for the PET proposed by Japan Otological Society (JOS).

Methods: We reviewed typical aural symptoms of PET, Eustachian tube (ET) obstruction procedure to confirm diagnosis of PET, objective findings of a patent ET obtainable from observation of the movement of the tympanic membrane, and by ET function tests (tubo-tympano-aerodynamic graphy, sonotubometry). In addition, usefulness of other tests such as patulous Eustachian tube handicap inventory-10 (PHI-10), sonotubometry with postural change (Ohta method), and sitting computed tomography (CT) to diagnose PET is described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0145561320925938DOI Listing

Neutrophil-to-lymphocyte ratio is a predictor of renal dysfunction in Japanese patients with type 2 diabetes.

Diabetes Metab Syndr 2020 Apr 27;14(4):481-487. Epub 2020 Apr 27.

Department of Community Medicine, Ehime University Graduate School of Medicine, Japan. Electronic address:

Background: Neutrophil-to-lymphocyte ratio (NLR) has been widely evaluated as a biomarker in various medical and surgical prognoses, but its usefulness in diabetic kidney disease is not yet known.

Methods: This prospective observational study included outpatients, comprised of 184 men aged 73 ± 11 (mean ± standard deviation) years and 174 women aged 76 ± 10 years at baseline, from a rural hospital. We examined the relationship between baseline NLR calculated by analyzing the differential leukocyte counts in the complete blood count and the 2-year estimated glomerular filtration rate (eGFR) decline rate (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dsx.2020.04.029DOI Listing

Recent increase in non-tuberculous mycobacterial infection in patients with connective tissue diseases in Japan.

J Infect Chemother 2020 May 3. Epub 2020 May 3.

Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan; National Hospital Organization Higashisaitama Hospital, Hasuda, 4147, Kurohama, Saitama, Japan.

Background: Non-tuberculous mycobacterial (NTM) infection is currently a growing health concern due to the increasing incidence and the need for prolonged therapy. In patients with connective tissue diseases, use of immunosuppressants may lead to an increased risk of NTM infection. However, few studies have examined the recent incidence of NTM infection among connective tissue diseases patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2020.04.013DOI Listing

Additional prognostic value of electrocardiographic left ventricular hypertrophy in traditional cardiovascular risk assessments in chronic kidney disease.

J Hypertens 2020 Jun;38(6):1149-1157

Department of Internal Medicine.

Background: Left ventricular hypertrophy (LVH) is a common predictor of the cardiovascular prognosis in chronic kidney disease (CKD). However, whether or not electrocardiography-derived LVH (ECG-LVH) has prognostic value in patients with various degrees of CKD and improves the cardiovascular risk stratification based on traditional risk factors remains unclear.

Methods: A total of 7206 participants at least 40 years of age who were free from cardiovascular events in a general population were followed for the incidence of cardiovascular events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/HJH.0000000000002394DOI Listing
June 2020
4.720 Impact Factor

Additional prognostic value of electrocardiographic left ventricular hypertrophy in traditional cardiovascular risk assessments in chronic kidney disease.

J Hypertens 2020 May 4. Epub 2020 May 4.

Department of Internal Medicine.

Background: Left ventricular hypertrophy (LVH) is a common predictor of the cardiovascular prognosis in chronic kidney disease (CKD). However, whether or not electrocardiography-derived LVH (ECG-LVH) has prognostic value in patients with various degrees of CKD and improves the cardiovascular risk stratification based on traditional risk factors remains unclear.

Methods: A total of 7206 participants at least 40 years of age who were free from cardiovascular events in a general population were followed for the incidence of cardiovascular events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/HJH.0000000000002394DOI Listing
May 2020
4.720 Impact Factor

Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma.

Mol Cancer Ther 2020 Jun 5;19(6):1363-1372. Epub 2020 May 5.

Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.

Esophageal squamous cell carcinoma (ESCC) is a disease characterized by a high mutation rate of the gene, which plays pivotal roles in the DNA damage response (DDR) and is regulated by checkpoint kinase (CHK) 2. CHK1 is another key DDR-related protein, and its selective inhibition is suggested to be particularly sensitive to -mutated cancers, because a loss of both pathways (CHK1 and/or CHK2-p53) is lethal due to the serious impairment of DDR. Such a therapeutic strategy is termed synthetic lethality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-19-0918DOI Listing

Histology-Independent Signature Distinguishes Kikuchi-Fujimoto Disease/Systemic Lupus Erythematosus-Associated Lymphadenitis From Benign and Malignant Lymphadenopathies.

Am J Clin Pathol 2020 May 5. Epub 2020 May 5.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

Objectives: Kikuchi-Fujimoto disease (KFD) and systemic lupus erythematosus (SLE) are benign entities with histologic features that raise concern about malignancy and infection. We searched for a histology-independent KFD/SLE signature relying on only immunophenotype and basic clinical characteristics.

Methods: A histology-independent KFD/SLE signature was generated using 975 excised lymph nodes with flow immunophenotyping, including 16 cases of KFD/SLE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa036DOI Listing

Kikuchi disease as a possible cause of ischaemic stroke: a case report.

Int J Neurosci 2020 May 7:1-3. Epub 2020 May 7.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Kikuchi disease (KFD) is a rare and self-limiting benign disease which usually occurs in young women. The difference between our case and the previous case is that the initial symptom of this case is transient ischemic attack (TIA). A 46-year-old female patient presented at the clinic with a 2-week history of paroxysmal left limb weakness and fever. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00207454.2020.1763341DOI Listing

Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice.

Life Sci Alliance 2020 Jun 28;3(6). Epub 2020 Apr 28.

Innate Immunity Laboratory, Graduate School of Life Science, Hokkaido University, Hokkaido, Japan

Crohn's disease (CD) is an intractable inflammatory bowel disease, and dysbiosis, disruption of the intestinal microbiota, is associated with CD pathophysiology. ER stress, disruption of ER homeostasis in Paneth cells of the small intestine, and α-defensin misfolding have been reported in CD patients. Because α-defensins regulate the composition of the intestinal microbiota, their misfolding may cause dysbiosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26508/lsa.201900592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190275PMC

The Difficulty of Diagnosing Kikuchi-Fujimoto Disease in Infants and Children Under Six Years Old: Case Report and Literature Review.

Authors:
Yasuji Inamo

Cureus 2020 Mar 24;12(3):e7383. Epub 2020 Mar 24.

Pediatrics, Nihon University School of Medicine, Tokyo, JPN.

We came across a 20-month-old boy with Kikuchi-Fujimoto disease (KFD) who showed atypical symptoms that were difficult to diagnose. His symptoms were different from those experienced in common clinical KFD cases. Hence, we report his case presentation and review the literature on the difference in KFD symptoms between infants and young children (under six years of age), and school-age children (6 to 20 years). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179985PMC

COVID-19 outbreak: An elusive enemy.

Authors:
Toshiaki Kikuchi

Respir Investig 2020 Apr 17. Epub 2020 Apr 17.

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan. Electronic address:

A novel coronavirus, officially termed as severe acute respiratory syndrome (SARS)-CoV-2, emerged in Wuhan, China, toward the end of 2019. Just four months later, more than 100,000 people were diagnosed with COVID-19, the resulting disease. The genetic analysis of SARS-CoV-2 revealed that this virus is a new Betacoronavirus, closely related to bat-derived SARS-like coronaviruses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.resinv.2020.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164855PMC

Classification Methods Based on Complexity and Synchronization of Electroencephalography Signals in Alzheimer's Disease.

Front Psychiatry 2020 7;11:255. Epub 2020 Apr 7.

Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan.

Electroencephalography (EEG) has long been studied as a potential diagnostic method for Alzheimer's disease (AD). The pathological progression of AD leads to cortical disconnection. These disconnections may manifest as functional connectivity alterations, measured by the degree of synchronization between different brain regions, and alterations in complex behaviors produced by the interaction among wide-spread brain regions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2020.00255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154080PMC

A Case of Kikuchi-Fujimoto Disease Associated with Erosive Lichen Planus.

Cureus 2020 Mar 18;12(3):e7312. Epub 2020 Mar 18.

Department of Dermatology, College of Medicine, King Saud University, Riyadh, SAU.

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting disorder with unknown etiology. The most frequent clinical manifestations include lymphadenopathy, fever, cutaneous lesions, arthritis, fatigue, and hepatosplenomegaly. Cutaneous manifestations of KFD, occurring in about one-third of patients, are typically non-specific, rarely presenting as symmetrically distributed lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164705PMC

Cervical Lymphadenopathy in Two Young Women The Same Rare Diagnosis with Different Presentations.

Eur J Case Rep Intern Med 2020 10;7(4):001516. Epub 2020 Mar 10.

Medicine Department, Internal Medicine Service, Hospital Sousa Martins, Guarda, Portugal.

Kikuchi-Fujimoto disease (KFD) is a rare, benign and usually self-limiting disorder that more often affects young women, which is characterized by cervical lymphadenopathy and fever. Clinical presentation may be indistinguishable from other diseases, and its inclusion in the differential diagnosis of lymphoproliferative, infective and autoimmune diseases is essential. An association with systemic lupus erythematosus is acknowledged. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2020_001516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162575PMC

Therapeutic potential for insulin on type 1 diabetes-associated periodontitis: Analysis of experimental periodontitis in streptozotocin-induced diabetic rats.

J Diabetes Investig 2020 Apr 17. Epub 2020 Apr 17.

Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.

Aims/introduction: The association between diabetes and periodontal disease is considered to be bidirectional. However, there is still controversy surrounding the relationship between periodontal disease and type 1 diabetes. We investigated whether insulin improves periodontitis without any local treatments for periodontitis under type 1 diabetes conditions using the ligature-induced experimental periodontitis model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdi.13276DOI Listing

Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method.

PLoS One 2020 15;15(4):e0231656. Epub 2020 Apr 15.

Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

It has been reported that 20% of early-stage oral squamous cell carcinoma (OSCC) patients treated with surgery alone (SA) may exhibit postoperative relapse within 2-3 years and have poor prognoses. We aimed to determine the safety of S-1 adjuvant chemotherapy and the potential differences in the disease-free survival (DFS) between patients with T2N0 (stage II) OSCC treated with S-1 adjuvant therapy (S-1) and those treated with SA. This single-center retrospective cohort study was conducted at Kumamoto University, between April 2004 and March 2012, and included 95 patients with stage II OSCC. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231656PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159208PMC

Adoption of personal protective measures by ordinary citizens during the COVID-19 outbreak in Japan.

Int J Infect Dis 2020 May 10;94:139-144. Epub 2020 Apr 10.

Department of Preventive Medicine and Public Health, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan. Electronic address:

Objectives: To clarify the implementation status of personal protective measures by ordinary citizens in Japan during the coronavirus disease 2019 (COVID-19) outbreak.

Methods: This was a cross-sectional study based on internet-based survey. A total of 2400 people (50% male: 20-79 years) were selected between February 25 and 27, 2020, from registrants of an Internet research company, to complete a questionnaire. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2020.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194542PMC

[Efficacy of medicinal penetration on acupoint as adjunctive therapy on histiocytic necrotizing lymphadenitis of heat-toxin syndrome: a randomized controlled trial].

Zhongguo Zhen Jiu 2020 Apr;40(4):365-9

Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province.

Objective: To evaluate the clinical efficacy of medicinal penetration on acupoint combined with medication for histiocytic necrotizing lymphadenitis (HNL) of heat-toxin syndrome, and to explore the methods of improving the clinical effect.

Methods: A total of 72 cases with HNL with heat-toxin syndrome were randomly divided into an observation group and a control group, 36 cases in each group. The patients in the control group were treated with oral administration of prednisone tablets for 40 days (first 5 days: 10 mg, three times a day; since then, reduced by 5 mg every 7 days). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13703/j.0255-2930.20190421-k0001DOI Listing

Disease progression-associated alterations in fecal metabolites in SAMP1/YitFc mice, a Crohn's disease model.

Metabolomics 2020 04 10;16(4):48. Epub 2020 Apr 10.

Graduate School of Life Science, Hokkaido University, Sapporo, 060-0810, Japan.

Introduction: Crohn's disease (CD) is a chronic, relapsing inflammatory bowel disease affecting the gastrointestinal tract. Although its precise etiology has not been fully elucidated, an imbalance of the intestinal microbiota has been known to play a role in CD. Fecal metabolites derived from microbiota may be related to the onset and progression of CD OBJECTIVES: This study aimed to clarify the transition of gut microbiota and fecal metabolites associated with disease progression using SAMP1/YitFc mice, a model of spontaneous CD METHODS: The ileum tissues isolated from SAMP1/YitFc mice at different ages were stained with hematoxylin-eosin for histologic characterization with CD progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-020-01671-5DOI Listing

A Case of Chronic Limb-Threatening Ischemia with Heel Ulcers Cured by Revascularization and Partial Calcanectomy.

Ann Vasc Dis 2020 Mar;13(1):86-89

Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

Ischemic limbs with infected heel ulcers are often difficult to salvage. We present a case of an 82-year-old woman who had bilateral heel ulcers owing to chronic limb-threatening ischemia. She underwent right femoral-terminal posterior tibial artery bypass surgery, but right calcaneus osteomyelitis occurred and inhibited wound healing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3400/avd.cr.19-00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140168PMC

Clinical significance of arterial stiffness as a factor for hospitalization of heart failure with preserved left ventricular ejection fraction: a retrospective matched case-control study.

J Cardiol 2020 Apr 5. Epub 2020 Apr 5.

Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.

Background: Previous studies have been conducted to identify characteristics of patients with heart failure with preserved ejection fraction (HFpEF), but the risk factors of HFpEF remain unclear. We investigated the associations between arterial stiffness and the risk of hospitalization for HFpEF patients.

Methods: For the case group, we enrolled patients with preserved EF who had been hospitalized for HF from April 2013 to March 2015 and examined the cardio-ankle vascular index (CAVI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jjcc.2020.02.013DOI Listing

Sciatic Nerve Palsy following Curved Periacetabular Osteotomy.

Case Rep Orthop 2020 19;2020:8569285. Epub 2020 Mar 19.

Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo 650-0017, Japan.

Curved periacetabular osteotomy (CPO) is used for the treatment of dysplastic hips. Previous studies have reported satisfying outcomes and low rate of severe complications associated with this procedure; however, no case of postoperative sciatic nerve palsy has been reported. In this study, we describe a case of postoperative sciatic nerve palsy following CPO due to nerve strangulation by scar tissue without direct injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/8569285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106866PMC

Interaction between Angiotensin Receptor and β-Adrenergic Receptor Regulates the Production of Amyloid β-Protein.

Biol Pharm Bull 2020 ;43(4):731-735

Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University.

Alzheimer's disease (AD) is characterized by the formation of extracellular amyloid plaques containing the amyloid β-protein (Aβ) within the parenchyma of the brain. Aβ is considered to be the key pathogenic factor of AD. Recently, we showed that Angiotensin II type 1 receptor (ATR), which regulates blood pressure, is involved in Aβ production, and that telmisartan (Telm), which is an angiotensin II receptor blocker (ARB), increased Aβ production via ATR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b20-00007DOI Listing
January 2020

Marked Impairment of Endothelium-Dependent Digital Vasodilatations in Patients With Microvascular Angina: Evidence for Systemic Small Artery Disease.

Arterioscler Thromb Vasc Biol 2020 May 2;40(5):1400-1412. Epub 2020 Apr 2.

From the Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Objective: It remains to be elucidated whether and how endothelial functions are impaired in peripheral circulation of patients with coronary functional disorders, such as vasospastic angina (VSA) and microvascular angina (MVA). We simultaneously examined endothelial functions of peripheral conduit and resistance arteries in patients with coronary functional disorders, with a special reference to NO and endothelium-dependent hyperpolarization factors. Approach and Results: Based on the results of invasive coronary acetylcholine testing and coronary physiological measurements, we divided 43 patients into 3 groups; VSA, MVA, and VSA+MVA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.119.313704DOI Listing

[One case of histiocytic necrotizing lymphadenitis with severe thrombocytopenia].

Zhonghua Nei Ke Za Zhi 2020 Apr;59(4):314-315

Department of Fever Disease, The First Medical Center, The General Hospital of PLA, Beijing 100853, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112138-20191227-00845DOI Listing

The genetic architecture of the human cerebral cortex.

Authors:
Katrina L Grasby Neda Jahanshad Jodie N Painter Lucía Colodro-Conde Janita Bralten Derrek P Hibar Penelope A Lind Fabrizio Pizzagalli Christopher R K Ching Mary Agnes B McMahon Natalia Shatokhina Leo C P Zsembik Sophia I Thomopoulos Alyssa H Zhu Lachlan T Strike Ingrid Agartz Saud Alhusaini Marcio A A Almeida Dag Alnæs Inge K Amlien Micael Andersson Tyler Ard Nicola J Armstrong Allison Ashley-Koch Joshua R Atkins Manon Bernard Rachel M Brouwer Elizabeth E L Buimer Robin Bülow Christian Bürger Dara M Cannon Mallar Chakravarty Qiang Chen Joshua W Cheung Baptiste Couvy-Duchesne Anders M Dale Shareefa Dalvie Tânia K de Araujo Greig I de Zubicaray Sonja M C de Zwarte Anouk den Braber Nhat Trung Doan Katharina Dohm Stefan Ehrlich Hannah-Ruth Engelbrecht Susanne Erk Chun Chieh Fan Iryna O Fedko Sonya F Foley Judith M Ford Masaki Fukunaga Melanie E Garrett Tian Ge Sudheer Giddaluru Aaron L Goldman Melissa J Green Nynke A Groenewold Dominik Grotegerd Tiril P Gurholt Boris A Gutman Narelle K Hansell Mathew A Harris Marc B Harrison Courtney C Haswell Michael Hauser Stefan Herms Dirk J Heslenfeld New Fei Ho David Hoehn Per Hoffmann Laurena Holleran Martine Hoogman Jouke-Jan Hottenga Masashi Ikeda Deborah Janowitz Iris E Jansen Tianye Jia Christiane Jockwitz Ryota Kanai Sherif Karama Dalia Kasperaviciute Tobias Kaufmann Sinead Kelly Masataka Kikuchi Marieke Klein Michael Knapp Annchen R Knodt Bernd Krämer Max Lam Thomas M Lancaster Phil H Lee Tristram A Lett Lindsay B Lewis Iscia Lopes-Cendes Michelle Luciano Fabio Macciardi Andre F Marquand Samuel R Mathias Tracy R Melzer Yuri Milaneschi Nazanin Mirza-Schreiber Jose C V Moreira Thomas W Mühleisen Bertram Müller-Myhsok Pablo Najt Soichiro Nakahara Kwangsik Nho Loes M Olde Loohuis Dimitri Papadopoulos Orfanos John F Pearson Toni L Pitcher Benno Pütz Yann Quidé Anjanibhargavi Ragothaman Faisal M Rashid William R Reay Ronny Redlich Céline S Reinbold Jonathan Repple Geneviève Richard Brandalyn C Riedel Shannon L Risacher Cristiane S Rocha Nina Roth Mota Lauren Salminen Arvin Saremi Andrew J Saykin Fenja Schlag Lianne Schmaal Peter R Schofield Rodrigo Secolin Chin Yang Shapland Li Shen Jean Shin Elena Shumskaya Ida E Sønderby Emma Sprooten Katherine E Tansey Alexander Teumer Anbupalam Thalamuthu Diana Tordesillas-Gutiérrez Jessica A Turner Anne Uhlmann Costanza Ludovica Vallerga Dennis van der Meer Marjolein M J van Donkelaar Liza van Eijk Theo G M van Erp Neeltje E M van Haren Daan van Rooij Marie-José van Tol Jan H Veldink Ellen Verhoef Esther Walton Mingyuan Wang Yunpeng Wang Joanna M Wardlaw Wei Wen Lars T Westlye Christopher D Whelan Stephanie H Witt Katharina Wittfeld Christiane Wolf Thomas Wolfers Jing Qin Wu Clarissa L Yasuda Dario Zaremba Zuo Zhang Marcel P Zwiers Eric Artiges Amelia A Assareh Rosa Ayesa-Arriola Aysenil Belger Christine L Brandt Gregory G Brown Sven Cichon Joanne E Curran Gareth E Davies Franziska Degenhardt Michelle F Dennis Bruno Dietsche Srdjan Djurovic Colin P Doherty Ryan Espiritu Daniel Garijo Yolanda Gil Penny A Gowland Robert C Green Alexander N Häusler Walter Heindel Beng-Choon Ho Wolfgang U Hoffmann Florian Holsboer Georg Homuth Norbert Hosten Clifford R Jack MiHyun Jang Andreas Jansen Nathan A Kimbrel Knut Kolskår Sanne Koops Axel Krug Kelvin O Lim Jurjen J Luykx Daniel H Mathalon Karen A Mather Venkata S Mattay Sarah Matthews Jaqueline Mayoral Van Son Sarah C McEwen Ingrid Melle Derek W Morris Bryon A Mueller Matthias Nauck Jan E Nordvik Markus M Nöthen Daniel S O'Leary Nils Opel Marie-Laure Paillère Martinot G Bruce Pike Adrian Preda Erin B Quinlan Paul E Rasser Varun Ratnakar Simone Reppermund Vidar M Steen Paul A Tooney Fábio R Torres Dick J Veltman James T Voyvodic Robert Whelan Tonya White Hidenaga Yamamori Hieab H H Adams Joshua C Bis Stephanie Debette Charles Decarli Myriam Fornage Vilmundur Gudnason Edith Hofer M Arfan Ikram Lenore Launer W T Longstreth Oscar L Lopez Bernard Mazoyer Thomas H Mosley Gennady V Roshchupkin Claudia L Satizabal Reinhold Schmidt Sudha Seshadri Qiong Yang Marina K M Alvim David Ames Tim J Anderson Ole A Andreassen Alejandro Arias-Vasquez Mark E Bastin Bernhard T Baune Jean C Beckham John Blangero Dorret I Boomsma Henry Brodaty Han G Brunner Randy L Buckner Jan K Buitelaar Juan R Bustillo Wiepke Cahn Murray J Cairns Vince Calhoun Vaughan J Carr Xavier Caseras Svenja Caspers Gianpiero L Cavalleri Fernando Cendes Aiden Corvin Benedicto Crespo-Facorro John C Dalrymple-Alford Udo Dannlowski Eco J C de Geus Ian J Deary Norman Delanty Chantal Depondt Sylvane Desrivières Gary Donohoe Thomas Espeseth Guillén Fernández Simon E Fisher Herta Flor Andreas J Forstner Clyde Francks Barbara Franke David C Glahn Randy L Gollub Hans J Grabe Oliver Gruber Asta K Håberg Ahmad R Hariri Catharina A Hartman Ryota Hashimoto Andreas Heinz Frans A Henskens Manon H J Hillegers Pieter J Hoekstra Avram J Holmes L Elliot Hong William D Hopkins Hilleke E Hulshoff Pol Terry L Jernigan Erik G Jönsson René S Kahn Martin A Kennedy Tilo T J Kircher Peter Kochunov John B J Kwok Stephanie Le Hellard Carmel M Loughland Nicholas G Martin Jean-Luc Martinot Colm McDonald Katie L McMahon Andreas Meyer-Lindenberg Patricia T Michie Rajendra A Morey Bryan Mowry Lars Nyberg Jaap Oosterlaan Roel A Ophoff Christos Pantelis Tomas Paus Zdenka Pausova Brenda W J H Penninx Tinca J C Polderman Danielle Posthuma Marcella Rietschel Joshua L Roffman Laura M Rowland Perminder S Sachdev Philipp G Sämann Ulrich Schall Gunter Schumann Rodney J Scott Kang Sim Sanjay M Sisodiya Jordan W Smoller Iris E Sommer Beate St Pourcain Dan J Stein Arthur W Toga Julian N Trollor Nic J A Van der Wee Dennis van 't Ent Henry Völzke Henrik Walter Bernd Weber Daniel R Weinberger Margaret J Wright Juan Zhou Jason L Stein Paul M Thompson Sarah E Medland

Science 2020 03;367(6484)

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aay6690DOI Listing
March 2020
31.477 Impact Factor

Oral mite anaphylaxis after ingestion of Korean pancake.

Respir Med Case Rep 2020 4;30:101026. Epub 2020 Mar 4.

Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuou, Ami, Inashiki, Ibaraki, 300-0395, Japan.

Background: Oral mite anaphylaxis (OMA) is a syndrome characterized by severe allergic manifestations occurring in atopic patients shortly after the intake of foods made with mite-contaminated wheat flour. A history of atopic disease has been identified as one of risk factors for the development of OMA. This is the report that OMA was induced by the ingestion of Korean pancake prepared with commercial mixed wheat flour contaminated with mites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmcr.2020.101026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068120PMC

Cervical lymphadenopathy in children: a diagnostic tree analysis model based on ultrasonographic and clinical findings.

Eur Radiol 2020 Mar 18. Epub 2020 Mar 18.

Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea.

Objectives: To establish a diagnostic tree analysis (DTA) model based on ultrasonography (US) findings and clinical characteristics for differential diagnosis of common causes of cervical lymphadenopathy in children.

Methods: A total of 242 patients (131 boys, 111 girls; mean age, 11.2 ± 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-020-06794-wDOI Listing

An atypical neurologic complication of Kikuchi-Fujimoto Disease.

Neurol Neuroimmunol Neuroinflamm 2020 May 16;7(3). Epub 2020 Mar 16.

From the Department of Neurology, University of Texas Southwestern, Dallas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXI.0000000000000707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136040PMC

Zinc transporter 8 autoantibodies complement glutamic acid decarboxylase and insulinoma-associated antigen-2 autoantibodies in the identification and characterization of Japanese type 1 diabetes.

J Diabetes Investig 2020 Mar 16. Epub 2020 Mar 16.

Sakai City Medical Center, Sakai, Japan.

Aims/introduction: This study aimed to investigate the significance of zinc transporter 8 autoantibody (ZnT8A) in identifying and characterizing autoimmune-mediated type 1 diabetes in Japanese individuals.

Methods: ZnT8A were determined in 324 patients with type 1 diabetes, 191 phenotypic type 2 diabetes and 288 healthy control individuals using bridging-type enzyme-linked immunosorbent assay in addition to autoantibodies to glutamic acid decarboxylase and insulinoma-associated antigen-2.

Results: We set a cut-off value of 10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdi.13251DOI Listing

Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis.

Arthritis Res Ther 2020 03 12;22(1):46. Epub 2020 Mar 12.

Department of Rheumatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Background: Abatacept (ABA) is a biological disease-modifying antirheumatic drug (bDMARD) for rheumatoid arthritis (RA). The aim of this study was to identify molecules that are associated with therapeutic responses to ABA in patients with RA.

Methods: Peripheral blood was collected using a PAX gene Blood RNA kit from 45 bDMARD-naïve patients with RA at baseline and at 6 months after the initiation of ABA treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13075-020-2137-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068901PMC

Sensing Peroxynitrite in Different Organelles of Murine RAW264.7 Macrophages With Coumarin-Based Fluorescent Probes.

Front Chem 2020 20;8:39. Epub 2020 Feb 20.

Department of Chemistry, University of Bath, Bath, United Kingdom.

The elucidation of biological processes involving reactive oxygen species (ROS) facilitates a better understanding of the underlying progression of non-communicable diseases. Fluorescent probes are a powerful tool to study various ROS and have the potential to become essential diagnostic tools. We have developed a series of coumarin fluorescent probes for the selective and sensitive detection of peroxynitrite (ONOO), a key ROS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fchem.2020.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044669PMC
February 2020

Prognostic significance of the radiologic features of pneumonitis induced by anti-PD-1 therapy.

Cancer Med 2020 May 9;9(9):3070-3077. Epub 2020 Mar 9.

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background: Interstitial lung disease (ILD) induced by anti-programmed-cell death-1 (PD-1) and anti-PD-ligand 1 (PD-L1) is potentially life-threatening and is a common reason of the discontinuation of therapy. In contrast, an enhancement in antitumor effects was reported in patients who developed immune-related adverse events, including ILD. Although recent evidence suggests that radiologic patterns of ILD may reflect the severity of ILD and the antitumor immune responses to anti-PD-1/PD-L1 therapies, the association between radiologic features and clinical outcomes remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cam4.2974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196069PMC

Pulmonary Onset of Adult Onset Still's Disease Complicated with Kikuchi Lymphadenitis.

Case Rep Rheumatol 2020 19;2020:8327068. Epub 2020 Feb 19.

University Medical Unit, Teaching Hospital Karapitiya, Galle, Sri Lanka.

Background: Adult onset Still's disease (AOSD) is a rare inflammatory disorder with a variety of clinical presentations. Even though pneumonitis and pleurisy are known to occur in AOSD, pulmonary onset presentations are exceedingly rare. . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/8327068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053467PMC
February 2020

The pretreatment neutrophil-to-lymphocyte ratio is a novel biomarker for predicting clinical responses to pembrolizumab in platinum-resistant metastatic urothelial carcinoma patients.

Urol Oncol 2020 Jun 2;38(6):602.e1-602.e10. Epub 2020 Mar 2.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Purpose: We investigated the relationship between pretreatment neutrophil-to-lymphocyte ratio (pre-NLR) levels just before the initiation of treatment with pembrolizumab and clinical outcomes in platinum-resistant metastatic urothelial carcinoma (UC) patients treated with pembrolizumab.

Methods: Our study population comprised 78 patients diagnosed with metastatic UC and treated with pembrolizumab after platinum-based chemotherapy at our institutions between December 2017 and April 2019. We examined the relationships between pre-NLR levels just before pembrolizumab treatment and clinical outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2020.02.005DOI Listing

Polygenic Architecture of Human Neuroanatomical Diversity.

Cereb Cortex 2020 Apr;30(4):2307-2320

Human Genetics and Cognitive Functions Unit, Institut Pasteur, UMR 3571, CNRS, Université Paris Diderot, Paris 75015, France.

We analyzed the genomic architecture of neuroanatomical diversity using magnetic resonance imaging and single nucleotide polymorphism (SNP) data from >26 000 individuals from the UK Biobank project and 5 other projects that had previously participated in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our results confirm the polygenic architecture of neuroanatomical diversity, with SNPs capturing from 40% to 54% of regional brain volume variance. Chromosomal length correlated with the amount of phenotypic variance captured, r ~ 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cercor/bhz241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175006PMC
April 2020
8.665 Impact Factor

Fructo-oligosaccharides ameliorate steatohepatitis, visceral adiposity, and associated chronic inflammation via increased production of short-chain fatty acids in a mouse model of non-alcoholic steatohepatitis.

BMC Gastroenterol 2020 Feb 27;20(1):46. Epub 2020 Feb 27.

Fourth Department of Internal Medicine, Teikyo University Mizonokuchi Hospital, 5-1-1 Futako, Takatsu-ku, Kawasaki-shi, Kanagawa, 213-8507, Japan.

Background: Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Within the spectrum of NAFLD, non-alcoholic steatohepatitis (NASH) in combination with hepatic inflammation and fibrosis can lead to liver cirrhosis and hepatocellular carcinoma. Dysbiosis was reported to contribute to NASH pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12876-020-01194-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045471PMC
February 2020