4,846 results match your criteria Kikuchi Disease

Patulous Eustachian Tube Patients with Respiratory Fluctuation of Tympanic Membrane in Both Sitting and Supine Positions: A Sign of Severity of Disease?

Otol Neurotol 2021 May 12. Epub 2021 May 12.

Sen-En Rifu Otological Surgery Center, Miyagi Department of Otolaryngology-Head and Neck Surgery, Tohoku University School of Medicine, Sendai, Japan.

Objective: The aim is to report four cases of patulous Eustachian tube (PET) patients with respiratory fluctuation of the tympanic membrane (TM) even in the supine position, and to examine the frequency and characteristics of such patients.

Patients: There were 195 ears (99 right ears and 96 left ears) from 146 cases (56 male and 90 female subjects aged 8-88, average 48.0 ± 18. Read More

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Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer's disease mouse model.

Sci Rep 2021 May 12;11(1):9749. Epub 2021 May 12.

Division of Neuroscience, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate, 028-3694, Japan.

Conjugated linoleic acid (CLA) is an isomer of linoleic acid (LA). The predominant dietary CLA is cis-9, trans-11-CLA (c-9, t-11-CLA), which constitutes up to ~ 90% of total CLA and is thought to be responsible for the positive health benefits associated with CLA. However, the effects of c-9, t-11-CLA on Alzheimer's disease (AD) remain to be elucidated. Read More

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Upregulated expression of a subset of genes in ;/ mice: Evidence of an interaction between diabetes-linked obesity and Alzheimer's disease.

FASEB Bioadv 2021 May 2;3(5):323-333. Epub 2021 Mar 2.

Department of Aging Neurobiology Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu Aichi Japan.

Clinical studies have indicated that obesity and diabetes are associated with Alzheimer's disease (AD) and neurodegeneration. However, the mechanism by which obesity/diabetes and AD interact with each other and contribute to dementia remains elusive. To obtain insights into their interaction at molecular levels, we performed gene expression analysis of ;/ mice, which were generated by crossing transgenic AD model mice (APP23 mice) with / mice, which are obese and mildly diabetic. Read More

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Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation.

J Cell Physiol 2021 May 10. Epub 2021 May 10.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Growing evidence suggest the association between Moyamoya disease (MMD) and immune systems, such as antigen presenting cells in particular. Rnf213 gene, a susceptibility gene for MMD, is highly expressed in immune tissues, however, its function remains unclear. In addition, the physiological role of RNF213 gene polymorphism c. Read More

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The effectiveness of plasma miR-33a-5p as a predictive biomarker for the efficacy of colorectal cancer chemotherapy.

Oncol Lett 2021 Jun 22;21(6):489. Epub 2021 Apr 22.

Department of Gastrointestinal Surgery, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan.

Several chemotherapeutic options are available for patients with metastatic colorectal cancer (mCRC), making it important to individualize treatment regimens. Individualization requires the clinical application of biomarkers for regimen selection, which is presently insufficient. miRNAs serve an important role in the control of biological processes in several types of cancer, acting as plasma biomarkers. Read More

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Alcohol consumption and serum uric acid are synergistically associated with renal dysfunction among community-dwelling persons.

J Clin Lab Anal 2021 May 7:e23812. Epub 2021 May 7.

Department of Community Medicine, Ehime University Graduate School of Medicine, Toon, Japan.

Background: Serum uric acid (SUA) is a key risk factor contributing to renal failure, a serious public health problem. However, few studies have examined whether the interactive relationship between alcohol consumption and SUA is independently associated with the estimated glomerular filtration rate (eGFR).

Methods: Our sample comprised 742 men aged 69 ± 11 years (mean ± standard deviation) and 977 women aged 69 ± 10 years from a rural area. Read More

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Case Report: Histiocytic Necrotizing Lymphadenitis (Kikuchi-Fujimoto Disease) Concurrent With Aseptic Meningitis.

Front Neurol 2021 20;12:565387. Epub 2021 Apr 20.

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, benign, self-limiting disease characterized by local lymphadenopathy. Central nervous system involvement in KFD is extremely rare and remains a diagnostic challenge. Only 41 cases of aseptic meningitis associated with KFD have been reported worldwide, with just four cases (including our case) of KFD with meningitis as the first symptom. Read More

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Soluble thrombomodulin and cardiovascular disease risk factors in Japanese children.

Blood Coagul Fibrinolysis 2021 Jun;32(4):273-277

Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

This study aimed to establish standard reference values for soluble thrombomodulin in healthy prepubertal school-aged children and elucidate the relationship between soluble thrombomodulin levels and obesity, metabolic syndrome-associated indices, and other markers of vascular endothelial damage. The participants in this study were healthy Japanese children aged 9-10 years (315 boys and 267 girls). Blood tests for soluble thrombomodulin, leptin, fibrinogen, and general biochemical markers were performed, and the mean and 10th, 50th, and 90th percentiles for each marker were determined. Read More

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CE-MS-Based Identification of Uremic Solutes Specific to Hemodialysis Patients.

Toxins (Basel) 2021 04 30;13(5). Epub 2021 Apr 30.

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

Uremic toxins are suggested to be involved in the pathophysiology of hemodialysis (HD) patients. However, the profile of uremic solutes in HD patients has not been fully elucidated. In this study using capillary electrophoresis mass spectrometry (CE-MS), we comprehensively quantified the serum concentrations of 122 ionic solutes before and after HD in 11 patients. Read More

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Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer's disease.

Alzheimers Res Ther 2021 May 3;13(1):92. Epub 2021 May 3.

Institute of Education, Tokyo Medical and Dental University, 20F, M&D Tower, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Background: Identifying novel therapeutic targets is crucial for the successful development of drugs. However, the cost to experimentally identify therapeutic targets is huge and only approximately 400 genes are targets for FDA-approved drugs. As a result, it is inevitable to develop powerful computational tools that can identify potential novel therapeutic targets. Read More

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Glasgow prognostic score for prediction of chemotherapy-triggered acute exacerbation interstitial lung disease in patients with small cell lung cancer.

Thorac Cancer 2021 May 3. Epub 2021 May 3.

Department of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.

Background: Predicting the incidence of chemotherapy-triggered acute exacerbation of interstitial lung disease (AE-ILD) in patients with lung cancer is important because AE-ILD confers a poor prognosis. The Glasgow prognostic score (GPS), which is an inflammation-based index composed of serum levels of C-reactive protein and albumin, predicts prognosis in patients with small cell lung cancer (SCLC) without ILD. In this study, we investigated AE-ILD and survival outcome based on the GPS in patients with ILD associated with SCLC who were receiving chemotherapy. Read More

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Extent of disease affects the usefulness of fecal biomarkers in ulcerative colitis.

BMC Gastroenterol 2021 May 1;21(1):197. Epub 2021 May 1.

Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan.

Background: Fecal biomarkers are considered to be useful surrogate markers for endoscopic activity. Given the mechanisms of fecal biomarkers, we hypothesized that the extent of ulcerative colitis (UC; pancolitis, left-sided colitis, and proctitis) could affect the usefulness of fecal biomarkers for assessing endoscopic and clinical disease activity; however, few studies have evaluated the utility of fecal biomarkers in the disease extent of UC.

Methods: Fecal calprotectin, a fecal immunochemical test for hemoglobin, and fecal lactoferrin were used as fecal biomarkers. Read More

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Exploratory research on asthma exacerbation risk factors using the Japanese claims database and machine learning: A retrospective cohort study.

J Asthma 2021 Apr 29:1-19. Epub 2021 Apr 29.

Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.

Objective: Analytical studies of risk factor assessment using machine learning have recently been reported. We performed an exploratory detection study of asthma exacerbation-related factors using health insurance claims data and machine learning to explore risk factors that have high generalizability and can be easily obtained in daily practice.

Methods: A dataset of asthma patients during May 2014-April 2019 from Japanese health insurance claims database, MediScope® (DB) was used. Read More

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Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma-A Retrospective Multicenter Study.

Medicina (Kaunas) 2021 Apr 12;57(4). Epub 2021 Apr 12.

Department of Otolaryngology-Head & Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. In total, 945 patients with OSCC were retrospectively analyzed. Read More

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Cellular-resolution gene expression profiling in the neonatal marmoset brain reveals dynamic species- and region-specific differences.

Proc Natl Acad Sci U S A 2021 May;118(18)

Laboratory for Molecular Mechanisms of Brain Development, Center for Brain Science, RIKEN, Saitama 351-0198, Japan;

Precise spatiotemporal control of gene expression in the developing brain is critical for neural circuit formation, and comprehensive expression mapping in the developing primate brain is crucial to understand brain function in health and disease. Here, we developed an unbiased, automated, large-scale, cellular-resolution in situ hybridization (ISH)-based gene expression profiling system (GePS) and companion analysis to reveal gene expression patterns in the neonatal New World marmoset cortex, thalamus, and striatum that are distinct from those in mice. Gene-ontology analysis of marmoset-specific genes revealed associations with catalytic activity in the visual cortex and neuropsychiatric disorders in the thalamus. Read More

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Long term outcomes of patients with poor prognostic factors following Transanal endoscopic microsurgery for early rectal cancer.

Colorectal Dis 2021 Apr 26. Epub 2021 Apr 26.

Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.

Introduction: Management of early rectal cancer following transanal microscopic anal surgery (TEMS) poses a management dilemma when the histopathology reveals poor prognostic features, due to high risk of local recurrence (LR). The aim of this study is to evaluate the oncological outcomes of such patients who either undergo surgery with total mesorectal excision (TME), receive adjuvant chemo/radiotherapy (CRDT/RT) or close surveillance only (no further treatment).

Methods: We identified patients with poor prognostic factors; pT2 adenocarcinoma, poor differentiation, deep submucosal invasion (kikuchi - SM3), lymphovascular invasion, tumour budding or R1 resection margin between 01. Read More

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A serial optical frequency-domain imaging study of early and late vascular responses to bioresorbable-polymer sirolimus-eluting stents for the treatment of acute myocardial infarction and stable coronary artery disease patients: results of the MECHANISM-ULTIMASTER study.

Cardiovasc Interv Ther 2021 Apr 25. Epub 2021 Apr 25.

Division of Cardiology, Department of Internal Medicine, Iwate Medical University, 2-1-1, Idai-Dori, Yahaba-Cho, Siwa-Gun, Yahaba, Iwate, 028-3695, Japan.

The purpose of this study was to assess early and late vascular healing in response to bioresorbable-polymer sirolimus-eluting stents (BP-SESs) for the treatment of patients with ST-elevation myocardial infarction (STEMI) and stable coronary artery disease (CAD). A total of 106 patients with STEMI and 101 patients with stable-CAD were enrolled. Optical frequency-domain images were acquired at baseline, at 1- or 3-month follow-up, and at 12-month follow-up. Read More

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A Case of Hb Aalborg (: c.223G>C) with Chronic Obstructive Pulmonary Disease: A First Familial Presentation in Japan.

Hemoglobin 2021 Apr 20:1-4. Epub 2021 Apr 20.

Department of Health Science, Yamaguchi University, Yamaguchi, Japan.

The proband was a male in his seventies who came to our facility because of shortness of breath. He was not anemic but presented dissociation between oxygen saturation (SpO) and partial pressure of oxygen (PaO) by blood gas analysis, and also demonstrated hemoglobinopathy after measurement of Hb A using high performance liquid chromatography (HPLC). Twenty-three percent of unknown hemoglobin (Hb) bands were detected. Read More

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First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate.

J Med Chem 2021 Apr 16. Epub 2021 Apr 16.

Cerevance Ltd, 418 Cambridge Science Park, Cambridge, U.K.

Parkinson's disease (PD) is a chronic and progressive movement disorder with the urgent unmet need for efficient symptomatic therapies with fewer side effects. GPR6 is an orphan G-protein coupled receptor (GPCR) with highly restricted expression in dopamine receptor D2-type medium spiny neurons (MSNs) of the indirect pathway, a striatal brain circuit which shows aberrant hyperactivity in PD patients. Potent and selective GPR6 inverse agonists (IAG) were developed starting from a low-potency screening hit (EC = 43 μM). Read More

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Potential of antibody test using Schistosoma mansoni recombinant serpin and RP26 to detect light-intensity infections in endemic areas.

Parasitol Int 2021 Apr 20;83:102346. Epub 2021 Apr 20.

Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; The Joint Usage/Research Center on Tropical Disease, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan; Nagasaki University, Kenya Research Station, NUITM-KEMRI Project, Nairobi, Kenya. Electronic address:

Schistosomiasis remains a worldwide public health problem, especially in sub-Saharan Africa. The World Health Organization targets the goal for its elimination as a public health problem in the 2030 Neglected Tropical Diseases (NTDs) Roadmap. Concerted action and agile responses to challenges will be necessary to achieve the targets. Read More

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High prevalence of serum anti-NH-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome.

J Neurol 2021 Apr 15. Epub 2021 Apr 15.

Department of Neurology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Background: Hashimoto's encephalopathy with serum anti-NH-terminal of α-enolase (NAE) antibodies occasionally displays clinical symptoms such as cerebellar ataxia and parkinsonism. We studied the frequency of anti-NAE antibodies in patients with Parkinson-plus syndrome.

Methods: We examined the positive rates of anti-NAE antibodies in 47 patients with multiple system atrophy (MSA), 29 patients with Parkinson's disease (PD), eight patients with corticobasal syndrome (CBS), and 18 patients with progressive supranuclear palsy (PSP) using conventional immunoblot analysis. Read More

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Correlation Between Longitudinal Strain in the Apical Segments of the Left Ventricle at End-Systole Obtained by 2-Dimensional Speckle-Tracking Echocardiography and Left Ventricular Relaxation.

Circ J 2021 Apr 10. Epub 2021 Apr 10.

Department of Cardiology, Nagoya City University Graduate School of Medical Sciences.

Background: It is well acknowledged that left ventricular (LV) contractile performance affects LV relaxation via LV elastic recoil. Accordingly, we aimed to investigate whether global longitudinal strain (GLS), particularly longitudinal strain at LV apical segments at end-systole (ALS), obtained by 2-dimensional speckle-tracking echocardiography could be used to assess LV relaxation.Methods and Results:We enrolled 121 patients with suspected or definite coronary artery disease in whom echocardiography and diagnostic cardiac catheterization were performed on the same day. Read More

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Identification of genes associated with Kikuchi-Fujimoto disease using RNA and exome sequencing.

Mol Cell Probes 2021 Jun 2;57:101728. Epub 2021 Apr 2.

Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Electronic address:

Kikuchi-Fujimoto disease (KFD) is an extremely rare disease, and although it is reported to have a worldwide distribution, young Asian women are most likely to be affected. Although this disease is generally benign and self-limiting, distinguishing it from other diseases that cause lymphadenopathy (e.g. Read More

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Intracellular Toxic AGEs (TAGE) Triggers Numerous Types of Cell Damage.

Biomolecules 2021 Mar 5;11(3). Epub 2021 Mar 5.

Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

The habitual intake of large amounts of sugar, which has been implicated in the onset/progression of lifestyle-related diseases (LSRD), induces the excessive production of glyceraldehyde (GA), an intermediate of sugar metabolism, in neuronal cells, hepatocytes, and cardiomyocytes. Reactions between GA and intracellular proteins produce toxic advanced glycation end-products (toxic AGEs, TAGE), the accumulation of which contributes to various diseases, such as Alzheimer's disease, non-alcoholic steatohepatitis, and cardiovascular disease. The cellular leakage of TAGE affects the surrounding cells via the receptor for AGEs (RAGE), thereby promoting the onset/progression of LSRD. Read More

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Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire.

Int J Mol Sci 2021 Mar 23;22(6). Epub 2021 Mar 23.

Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University, Tokushima 770-8503, Japan.

Prions are infectious agents causing prion diseases, which include Creutzfeldt-Jakob disease (CJD) in humans. Several cases have been reported to be transmitted through medical instruments that were used for preclinical CJD patients, raising public health concerns on iatrogenic transmissions of the disease. Since preclinical CJD patients are currently difficult to identify, medical instruments need to be adequately sterilized so as not to transmit the disease. Read More

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Acceptance of a COVID-19 Vaccine in Japan during the COVID-19 Pandemic.

Vaccines (Basel) 2021 Mar 3;9(3). Epub 2021 Mar 3.

Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo 160-8402, Japan.

Vaccination could be a key protective measure against coronavirus disease 2019 (COVID-19), and it is important to understand the acceptability of the COVID-19 vaccine among the general public. However, there is no study on the acceptance of a COVID-19 vaccine in Japan. Therefore, this study aimed to describe the COVID-19 vaccine acceptance and hesitancy situation in Japan and assess the factors associated with such issues. Read More

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Effects of dapagliflozin on mortality in patients with chronic kidney disease: a pre-specified analysis from the DAPA-CKD randomized controlled trial.

Eur Heart J 2021 Mar;42(13):1216-1227

The George Institute for Global Health, Level 5, 1 King Street, Newtown, Sydney, NSW 2042, Australia.

Aims : Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In this pre-specified analysis of the DAPA-CKD trial, we determined the effects of dapagliflozin on cardiovascular and non-cardiovascular causes of death.

Methods And Results : DAPA-CKD was an international, randomized, placebo-controlled trial with a median of 2. Read More

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Risk Factors for Totally Implantable Central Venous Access Port-related Infection in Patients With Malignancy.

Anticancer Res 2021 Mar;41(3):1547-1553

Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Background: We sought to identify the risk factors of totally implantable central venous access port (TICVAP)-related infections in patients with malignant disease.

Patients And Methods: Overall, 324 consecutive patients who received a TICVAP at our institution were retrospectively analysed. We further analysed cases of TICVAP-related complications. Read More

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A Case of Isolated Infragenicular Arterial Lesions Successfully Treated with Open Endarterectomy.

Ann Vasc Dis 2021 Mar;14(1):79-82

Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

A 68-year-old man with a history of superior mesenteric arterial thromboembolism due to chronic atrial fibrillation had experienced intermittent claudication (IC) of his left leg for 3 years. Computed tomography angiography showed focal occlusive lesions in the left distal popliteal artery and proximal segments of the infrapopliteal arteries. Endarterectomy was performed for these localized arterial lesions, and a drastic symptomatic improvement of IC after revascularization was achieved. Read More

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Disease burden and quality of life of patients with chronic cough in Japan: a population-based cross-sectional survey.

BMJ Open Respir Res 2021 Mar;8(1)

MSD KK, Chiyoda-ku, Tokyo, Japan.

Background: Cough lasting 3-8 and >8 weeks are defined as subacute/prolonged cough and chronic cough (CC), respectively. Studies have revealed that CC negatively impact patients' quality of life (QoL). In Japan, there is limited data on the impact of CC on health-related quality of life (HRQoL), work productivity and activity impairment (WPAI) and healthcare resource utilisation (HRU) using validated instruments. Read More

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