821,185 results match your criteria Kidney international. Supplement[Journal]
Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.
Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará-UFC. Fortaleza, Ceará, Brazil.
Background: Chikungunya virus (CHIKV) infection is a current public health problem. The aim of this study was to investigate risk factors for death among patients with CHIKV infection during a large epidemic in northeast Brazil.
Methods: This is a cross-sectional study with all registered cases of CHIKV in Ceara, Brazil, during 2016-2017. Read More
Nucleic Acids Res 2018 Dec;46(22):e131
Department of Biomedicine, Aarhus University, Denmark.
Extrachromosomal circular DNA (eccDNA) and ring chromosomes are genetic alterations found in humans with genetic disorders. However, there is a lack of genetic engineering tools to recapitulate and study the biogenesis of eccDNAs. Here, we created a dual-fluorescence biosensor cassette, which upon the delivery of pairs of CRISPR/Cas9 guide RNAs, CRISPR-C, allows us to study the biogenesis of a specific fluorophore expressing eccDNA in human cells. Read More
Biomed Pharmacother 2018 Dec 11;110:656-666. Epub 2018 Dec 11.
Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China. Electronic address:
Background: Renal cell carcinoma (RCC) is a most common kidney malignancy, with atypical symptoms in the early stage and poor outcome in the late stage. Recently, emerging evidence revealed that some miRNAs play an essential role in the tumorigenesis and progression of RCC. Therefore, the aim of this study is that understand the detailed molecular mechanism of miR-23a-3p in RCC and identify its potential clinical value. Read More
Chemosphere 2018 Dec 6;219:321-327. Epub 2018 Dec 6.
School of Life Science, Shanxi University, Taiyuan, Shanxi, 030006, China. Electronic address:
Experiments were carried out to investigate the bioaccumulation and elimination of cadmium (Cd) in tissues (kidney, gills, digestive gland, mantle, visceral mass, foot, adductor muscle and hemolymph) from the freshwater mussel, Anodonta woodiana. The mussels were exposed to subchronic Cd at concentrations of 0.168 and 0. Read More
Eur J Cancer 2018 Dec 11;107:79-85. Epub 2018 Dec 11.
Department of Cancer Medicine, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France.
Background: Bone metastases (BMs) are associated with significant morbidity and shorter survival in renal cell carcinoma (RCC). Our purpose was to identify prognostic factors for overall survival (OS) in RCC patients with BMs.
Methods: Data from patients with BMs from RCC treated at Gustave Roussy between April 1992 and March 2016 were retrospectively collected. Read More
Biosens Bioelectron 2018 Nov 25;126:707-724. Epub 2018 Nov 25.
Department of Zoology, M.D. University, Rohtak 124001, India.
Creatinine is a metabolic product of creatine phosphate in muscles, which provides energy to muscle tissues. Creatinine has been considered as indicator of renal function specifically after dialysis, thyroid malfunction and muscle damage. The normal level of creatinine in the serum and its excretion through urine in apparently healthy individuals is 45-140 μM and 0. Read More
Fish Shellfish Immunol 2018 Dec 11. Epub 2018 Dec 11.
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, 430072, PR China.
The present study was conducted to evaluate dietary inosine 5'-monophosphate (5'-IMP) on growth, immune genes expression and disease resistance against Aeromonas hydrophila in juvenile gibel carp (Carassius auratus gibelio var. CAS Ⅲ) (initial body weight: 7.48g). Read More
Cell Signal 2018 Dec 11. Epub 2018 Dec 11.
Dept. of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Chronic kidney disease (CKD) is a global health problem with a profound impact on quality of life. Cardiovascular disease is established as a major cause of morbidity and mortality in patients with CKD. Dyslipidemia is frequently observed in CKD patients, suggesting a causal relation between dyslipidemia and cardiovascular disease in CKD patients. Read More
Math Biosci 2018 Dec 11. Epub 2018 Dec 11.
Division of General Internal Medicine, Department of Medicine, Toronto General Hospital, Toronto.
In this work, a mathematical model was developed to simulate the urinary concentration mechanism. A 3-D geometry was derived based on the detail physiological pictures of rat kidney. The approximate region of each tubule was obtained from the volume distribution of structures based on Walter Pfaller's monograph and Layton's region-based model. Read More
PLoS One 2018 14;13(12):e0209156. Epub 2018 Dec 14.
Department of Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, South Korea.
Background: Serum uric acid (UA) level has been reported to be associated with chronic allograft nephropathy and graft failure in patients who undergo kidney transplantation (KT). However, the role of serum UA level in renal graft survival remains controversial.
Objective: This study aimed to investigate the effect of mean serum UA level during two different post-KT periods on long-term renal graft outcomes in a large population cohort in which living donor KT prevails. Read More
Curr Opin Urol 2018 Dec 12. Epub 2018 Dec 12.
Klinik und Poliklinik für Urologie, Universitätsklinikum Köln, Köln, Germany.
Purpose Of Review: The present review identifies the latest scientific investigations within the fields of fragmenting and dusting to discuss optimizing treatment. In addition, new settings such as 'popcorning' are scrutinized carefully.
Recent Findings: During the past years, endoscopic techniques have continuously developed and changed the management of the treatment of kidney stones using ureteroscopy (URS). Read More
Hum Vaccin Immunother 2018 Dec 14. Epub 2018 Dec 14.
a Department of Medicine , Duke University Medical Center , Durham , NC , USA.
Autoimmunity is a leading cause of chronic kidney disease and loss of native and transplanted kidneys. Conventional immunosuppressive therapies can be effective but are non-specific, noncurative, and risk serious side effects such as life-threatening infection and cancer. Novel therapies and targeted interventions are urgently needed. Read More
Salud Publica Mex 2018 Sep-Oct;60(5):559-565
School of Kinesiology and Health Studies, Queen's University. Kingston, Canada.
Objective: To identify challenges derived from renal insufficiency, as well as potential solutions and an agenda for action.
Materials And Methods: y adopting a collaborative research approach, diverse stakeholders -sick people, family members, advocacy groups, health professionals, and academics- participated in two gatherings in the context of the World Kidney Day in Guadalajara, Mexico and created an agenda for action. Data was gathered through group discussions. Read More
G Ital Nefrol 2018 Dec;35(6)
Department of Oral Surgery, Faculty of Dental medicine, Medical University, Plovdiv, Bulgaria.
Introduction: End-stage chronic kidney disease (CKD) is characterized by kidney failure with the organ's functions reduced or lost completely, where the kidneys are incapable of filtering excess fluids. Renal replacement therapy may be provided by peritoneal dialysis, hemodialysis or renal transplantation. Among the key indicators for tracking patients' current status are urea and creatinine levels. Read More
G Ital Nefrol 2018 Dec;35(6)
Psicologa Clinica, Psicoterapeuta Sistemico Relazionale IIPR, Psicologa Clinica Ismett, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione - IRCCS, Palermo.
The need for patients with a chronic kidney failure and on dialysis to embark on a kidney transplant process, poses the challenge to identify alternative and effective surgical strategies to overcome the insufficient number of deceased donors. The purpose is to allow the considerable number of patients on the kidney transplant waiting lists to receive appropriate treatment in time and under the most favorable clinical conditions. Living donation from a significant other is becoming increasingly widespread, on a national and international level. Read More
G Ital Nefrol 2018 Dec;35(6)
S.C. Nefrologia, Dialisi e Trapianto U. AOU Città della Salute e della Scienza di Torino, Torino, Italia.
Acute Kidney Injury (AKI) is a frequent complication of multiple myeloma (MM) with unfavorable prognostic significance. Light chains removal, combined with hematological therapy (CT) seems to offer significant benefits to renal function recovery (RFR). The SUPRA HFR, through the combination of high cut-off membrane without albumin loss and adsorbent cartridge, represents one of the "emerging" light chain removal methods. Read More
G Ital Nefrol 2018 Dec;35(6)
Unità di Fisiopatologia dell'Insufficienza Renale Acuta e Cronica - Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma.
Acute Kidney Injury (AKI) is an important issue for the healthcare system, as it is associated with high mortality and increased risk of readmission, with consequent elevated healthcare resource utilization. We investigated the incidence of AKI based on the examination of the discharge cards of all patients admitted between January 1 2011 and December 31 2015 at the Parma University Hospital, as well as the frequency and type of 30-day hospital readmission in the patients discharged with a first AKI diagnosis (index admission). The mean pooled 5-year incidence of AKI was 2. Read More
G Ital Nefrol 2018 Dec;35(6)
UO Nefrologia e Dialisi AUSL Romagna Ospedale Infermi Rimini.
Anabolic Androgenic Steroids (AAS) is an hormone family whose use has considerably increased among body-builders during the last decades. The AAS abuse, especially associated with other drugs or nutritional supplements and protein loads, may cause a variety of pathologies to several organs with a mechanism related to dosage, timing and substance. The kidney is the main metabolizer of these drugs and it can be acutely or chronically damaged with ESKD. Read More
G Ital Nefrol 2018 Dec;35(6)
U.O.C. Nefrologia, Università cattolica del sacro cuore. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
ADH is a hormone secreted by neurohypophysis that plays different roles based on the target organ. At the renal level, this peptide is capable of causing electrolyte-free water absorption, thus playing a key role in the hydro-electrolytic balance. There are pathologies and disorders that jeopardize this balance and, in this field, ADH receptor inhibitors such as Vaptans could play a key role. Read More
G Ital Nefrol 2018 Dec;35(6)
Membro del Direttivo SIN, esperto di organizzazione sanitaria, ex responsabile controllo di gestione ospedale di Perugia, ex coordinatore governo clinico SIN.
Nephrology continues to be in transition. While rates of kidney diseases and injury continue to rise, changes in the general health care system and the delivery of kidney care make it unclear how increases in need will be translated into demand for nephrologists. The changes in the delivery system also raise questions as to the future roles and career paths for nephrologists. Read More
Am J Transplant 2018 Dec 14. Epub 2018 Dec 14.
Critical Path Institute, Tucson, AZ, USA.
The Transplant Therapeutics Consortium (TTC) is a public-private partnership between the Food and Drug Administration and the transplantation community including the transplantation societies and members of the biopharmaceutical industry. The TTC was formed to accelerate the process of developing new medical products for transplant patients. The initial goals of this collaboration are: 1) To define which aspects of the kidney transplant drug-development process have clear needs for improvement from an industry and regulatory perspective; 2) To define which of the unmet needs in the process could be positively impacted through the development of specific drug development tools based on available data; and 3) To determine the most appropriate pathway to achieve regulatory acceptance of the proposed process-accelerating tools. Read More
Head Neck 2018 Dec 14. Epub 2018 Dec 14.
Department of Otolaryngology, Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel.
Background: Nonmelanoma skin cancers (NMSC) are the most common malignancies in solid organ recipients. We investigated the incidence, clinical features, and outcome of solid organ recipients with NMSC of the head and neck.
Methods: A retrospective chart review was conducted for solid organ recipients who were treated from 1992 to 2015 and who developed NMSC of the head and neck. Read More
Transpl Int 2018 Dec 14. Epub 2018 Dec 14.
Department of Renal and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Blood group O or B recipients wait longer for a kidney transplant. We studied the distribution of anti-ABO blood group antibody titres in patients awaiting a kidney transplant, and modelled the effect of altering the UK National Kidney Allocation Scheme to allow for patients with 'LOW' titres (≤1:8, ≤3 dilutions) to receive a deceased donor ABOi (ddABOi) transplant. In a prospective study of 239 adult patients on the waiting list for a transplant in 2 UK centres, ABO-antibody titres (anti-A and anti-B) were measured. Read More
Hepatology 2018 Dec 14. Epub 2018 Dec 14.
University of Michigan.
Background/aim: Monotherapy with interferon or nucleoside analog is generally not recommended during the immune tolerant (IT) phase of chronic hepatitis B virus (HBV) infection. Recognition that high HBV DNA levels are associated with hepatocellular carcinoma has increased interest in treating HBV in the IT phase. Small pediatric studies reported efficacy with combination nucleoside analog and interferon therapy. Read More
J Fish Dis 2018 Dec 14. Epub 2018 Dec 14.
Marine Harvest Canada, Campbell River, British Columbia, Canada.
Renibacterium salmoninarum infection causes bacterial kidney disease (BKD) in salmonid freshwater and saltwater life stages, with potentially severe financial loss for the aquaculture industry. Preventing vertical transmission, from infected broodstock to eggs, is key to disease management. As there is no perfect reference standard for detecting R. Read More
Hepatology 2018 Dec 14. Epub 2018 Dec 14.
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Hepatitis E virus (HEV) infection is a self-limited asymptomatic illness in immunocompetent patients, but may cause chronic infection in immunosuppressed, solid organ transplant recipients. Chronic HEV can result in aggressive inflammation and fibrosis, leading to cirrhosis in up to 10%(1). Current therapy has been limited to reducing immunosuppression and/or ribavirin which leads to viral clearance in 64-74% of patients. Read More
J Pathol 2018 Dec 14. Epub 2018 Dec 14.
Department of Medicine, Rush University Medical Center, Chicago, IL, USA.
The role of dynamin in regulation of kidney filtration barrier is well documented. Dynamin binds to and produces filamentous actin, which is a key component of healthy podocyte foot processes. Destruction of dynamin, for example by cathepsin L, leads to loss of a functional actin network and uncoordinated membrane signaling, a situation that allows for effacement of foot processes and proteinuria. Read More
Catheter Cardiovasc Interv 2018 Dec 13. Epub 2018 Dec 13.
Cardiology department, Tel Aviv Sourasky Medical Center, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Objective: To compare procedural outcomes of transcatheter aortic valve implantation (TAVI) patients who were implanted with older versus newer generation valves.
Background: The current evidence base for improved safety of the newer commercially available TAVI valves is limited.
Methods: A retrospective analysis of the Israeli multicenter TAVI registry was performed. Read More
Neurogastroenterol Motil 2018 Dec 13:e13509. Epub 2018 Dec 13.
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Background: Anxiety and depression are implicated as contributors to abdominal pain in pediatric irritable bowel syndrome (IBS) but is unclear if this pain is associated with other psychological factors. The study objective was to test if the impact of anxiety or depression on IBS symptom severity is mediated by somatization and/or pain catastrophizing.
Methods: We utilized baseline data from local pediatric IBS clinical studies. Read More
Semin Dial 2018 Dec 13. Epub 2018 Dec 13.
UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, Paris, France.
Hepatitis C virus (HCV) infection has been demonstrated to result in several adverse hepatic outcomes and has been associated with a number of important extrahepatic manifestations. The scope of extrahepatic clinical possibilities includes systemic diseases such as vasculitis and lymphoproliferative disorders, cardiovascular disease, myalgia, arthritis, and sicca syndrome. These end-organ effects of HCV may dominate the clinical course beyond the hepatic complications and significantly worsen the long-term prognosis of infected patients. Read More
Compr Physiol 2018 Dec 13;9(1):439-455. Epub 2018 Dec 13.
Blood Research Institute, BloodCenter of Wisconsin, a part of Versiti, Milwaukee, Wisconsin, USA.
Gene expression is regulated by numerous elements including enhancers, insulators, transcription factors, and architectural proteins. Regions of DNA distal to the transcriptional start site, called enhancers, play a central role in the temporal and tissue-specific regulation of gene expression through RNA polymerase II. The identification of enhancers and other cis regulatory elements has largely been possible due to advances in next generation sequencing technologies. Read More
J Leukoc Biol 2018 Dec 13. Epub 2018 Dec 13.
Kidney Transplantation Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand-receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL-10. Read More
Clin Transplant 2018 Dec 13:e13463. Epub 2018 Dec 13.
Urology and Nephrology Center, Nephrology division, Mansoura University, Egypt.
In a prospective randomized controlled trial, between May 2001 and January 2003, 132 live donor kidney transplant recipients were randomized to receive sirolimus primary immunosuppression, either in combination with low dose tacrolimus (TAC group) or in combination with mycophenolate mofetil (MMF group). We have previously reported on two and five year- follow up results, with favorable patient and graft outcomes obtained in both groups. In view of recent published reports of increased risk of inferior outcomes among sirolimus- treated patients, we herein present results of an observational extension of the previously randomized patients 15 years post -transplantation. Read More
Hemodial Int 2018 Dec 13. Epub 2018 Dec 13.
Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Despite substantial improvements following the introduction of novel agents and antibodies, amyloid light-chain (AL)-amyloidosis still carries a grim prognosis. Here, we report on the case of a severely frail 86-year-old patient suffering from monoclonal gammopathy of renal significance (MGRS)-associated AL-amyloidosis with a diuretic-refractory nephrotic syndrome. In this patient, treatment with bortezomib-dexamethasone effectively induced a serological response, but was unfortunately poorly tolerated and failed to promote renal recovery fast enough to prevent secondary complications. Read More
Transpl Infect Dis 2018 Dec 13:e13035. Epub 2018 Dec 13.
Division of Infectious Diseases, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil.
Background: Late CMV infections (LCMV) after the cessation of prophylaxis are well described. We aimed to assess clinical and epidemiological data on late occurring CMV infections in the absence of CMV prophylaxis in a cohort of kidney transplant patients.
Methods: In a cohort of kidney transplant recipients not employing CMV specific prophylaxis, patients with CMV infections occurring after the six month of transplantation were compared to patients with CMV infections diagnosed within the first six months (early infections). Read More
Clin Transplant 2018 Dec 13:e13464. Epub 2018 Dec 13.
Clínica Universitaria Colombia, Fundacion Universitária de Ciencias de la Salud, Bogotá, Colombia.
While calcineurin inhibitors (CNIs) are effective for preventing acute rejection in kidney transplant recipients, long-term use may cause chronic kidney injury and is associated with increased risks of cardiovascular events, cancer, and infection-associated death. Immunosuppression strategies are needed to balance risks of acute and subclinical rejection with long-term benefits of improved kidney function. Sirolimus, an inhibitor of mammalian target of rapamycin, is used for immunosuppression in kidney transplantation. Read More
J Cell Biochem 2018 Dec 13. Epub 2018 Dec 13.
Health research institute,, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ischemia-reperfusion injury refers to a temporary interruption of blood flow in a tissue. Restoration of blood flow initiates the inflammation in tissue causing ischemic damage through the activation of a multiprotein complex termed inflammasome. The complex contains a receptor, mainly a member of nucleotide oligomerization domain-like receptors, that receives danger signals. Read More
Transbound Emerg Dis 2018 Dec 12. Epub 2018 Dec 12.
College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China.
Avian leukosis virus subgroup J (ALV-J) was isolated in meat-type breeder chickens for the first time in 1988 in the United Kingdom. Due to the application of an eradication program, there were fewer reports related to myelocytomatosis or ALV-J in China after 2013. However, there was another breakout almost simultaneously in six provinces of China in February 2018. Read More
Proteomics Clin Appl 2018 Dec 13:e1800135. Epub 2018 Dec 13.
A. K. Lucas-Herald, B. Mansoorian, W. Mullen, C. Delles, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Background: Progeria-like syndromes offer a unique insight into ageing. Here we present the case of a boy affected with mandibuloacral dysplasia and compound heterozygous mutations in ZMPSTE24.
Methods: Capillary electrophoresis-mass spectroscopy was used for proteome analysis to analyse peptides previously found to be differentially regulated in chronic kidney disease (273 peptides defining the CKD273 classifier), coronary artery disease (238 peptides defining the CAD238 classifier) and ageing (116 peptides defining the AGE116 classifier). Read More
Macromol Biosci 2018 Dec 13:e1800412. Epub 2018 Dec 13.
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99,, 3584, CG Utrecht, The Netherlands.
The increasing prevalence of end-stage renal disease and persistent shortage of donor organs call for alternative therapies for kidney patients. Dialysis remains an inferior treatment as clearance of large and protein-bound waste products depends on active tubular secretion. Biofabricated tissues could make a valuable contribution, but kidneys are highly intricate and multifunctional organs. Read More
Genesis 2018 Dec 13:e23270. Epub 2018 Dec 13.
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Intermediate mesoderm (IM) is the strip of tissue lying between the paraxial mesoderm (PAM) and the lateral plate mesoderm that gives rise to the kidneys and gonads. Chick fate mapping studies suggest that IM is specified shortly after cells leave the primitive streak and that these cells do not require external signals to express IM-specific genes (James and Schultheiss, 2003). Surgical manipulations of the chick embryo, however, revealed that PAM-specific signals are required for IM differentiation into pronephros - the first kidney (Mauch et al. Read More
Pediatr Transplant 2018 Dec 12:e13333. Epub 2018 Dec 12.
Division of Nephrology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington.
Background: Studies of HRQoL after kidney transplant have yielded conflicting results. We sought to assess the impact of kidney transplant on HRQoL.
Methods: We performed a retrospective study using the PedsQL3. Read More
Geriatr Gerontol Int 2018 Dec 12. Epub 2018 Dec 12.
Geriatric Unit, Internal Medicine Department, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Aim: To assess whether 1-year mortality in older patients experiencing a first admission for acute heart failure was related to sex, and to explore differential characteristics according to sex.
Methods: We reviewed the medical records of 1132 patients aged >70 years of age admitted within a 3-year period because of a first episode of acute heart failure. We analyzed sex differences. Read More
J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China.
Oxidative stress is important for the calcium oxalate (CaOx)-induced kidney stone formation. Sirtuin 3 (SIRT3) plays an essential role in the amelioration of oxidative damages. This study aims to explore the effect of SIRT3 on the formation of CaOx-induced kidney stones and the underlying mechanism. Read More
J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Renal failures treatment has been faced with several problems during the last decades. Kidney tissue engineering has been created many hopes to improve treatment procedures with scaffold fabrication that can modulate kidney cells/stem cells migration to the lesion site and increase the survival of these cells at that site with imitating the role of the kidney extracellular matrix. In this study, bone morphogenetic protein-7 (BMP7) as a vital factor for kidney development and regeneration was incorporated in the polycaprolactone (PCL) nanofibers and after morphological, mechanical, and biocompatible characterization, proliferation, and survival of the human embryonic kidney cells (HEK) were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), flow cytometry, and gene expression while cultured on scaffolds. Read More
Transpl Infect Dis 2018 Dec 12:e13037. Epub 2018 Dec 12.
Division of Infectious Diseases, Carver College of Medicine University of Iowa, Iowa City, IA, USA.
Q fever is uncommon in solid organ transplant (SOT) recipients. We describe a case of granulomatous lung disease as an unusual presentation of chronic Q fever in a kidney-pancreas transplant recipient. This article is protected by copyright. Read More
J Ren Care 2018 Dec 12. Epub 2018 Dec 12.
University of Nottingham, Nottingham, UK.
Background: Young people with chronic kidney disease (CKD) have a number of key issues and life changes to manage while also possibly transitioning into adult care. During this time, the nature of their support networks including, social, romantic, family and health care relationships, is changing.
Objective: To explore these young people's experience and perceptions of their past, current and future relationships and support networks. Read More
Catheter Cardiovasc Interv 2018 Dec 12. Epub 2018 Dec 12.
University of Miami-JFK Medical Center Palm Beach Regional GME Consortium, Atlantis, Florida.
Objectives: To assess the impact of WATCHMAN™ on quality of life (QoL) in octogenarians and nonagenarians.
Background: QoL after WATCHMAN™ device in the elderly remains unknown.
Methods: This is a prospective and retrospective cohort study of patients that underwent WATCHMAN™ implantation in a tertiary cardiovascular center from April 1, 2015 to September 27, 2017. Read More
J Diabetes Investig 2018 Dec 11. Epub 2018 Dec 11.
Laboratório de Carboidratos e Radioimunoensaio LIM-18, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR. Av. Dr. Arnaldo, 455São Paulo, SP, BR.
Aims/introduction: Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications.
Material And Methods: We assessed the frequency of 5 single nucleotide polymorphisms (SNPs) in the gene encoding DNA methytransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414, and rs10854076) and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy (CAN) in 359 long-term Type 1 diabetes individuals. Read More
J Clin Pharm Ther 2018 Dec 11. Epub 2018 Dec 11.
Department of Pharmacy, The First Hospital of Jilin University, Changchun, Jilin, China.
What Is Known And Objective: Aristolochic acid (AA) is an abundant compound in Aristolochia plants and various natural herbs. In the 1990s, a slimming formula used in Belgium that contains Aristolochia fangchi was reported to cause kidney damage and bladder cancer, and aristolochic acid nephropathy (AAN) is now well recognized worldwide. In October 2017, researchers reported an AA signature that is closely associated with hepatocellular carcinoma (HCC) worldwide. Read More