19,638 results match your criteria Kidney international[Journal]


Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy.

Kidney Int 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Ectopic fat deposition (EFD) in the kidney has been shown to play a causal role in diabetic nephropathy; however, the mechanism underlying EFD remains elusive. By transcriptome analysis, we found decreased expression levels of disulfide-bond A oxidoreductase-like protein (DsbA-L) in the kidneys of diabetic mice (induced by high-fat diet plus Streptozotocin) compared with control mice. Increased expression of adipocyte differentiation-related protein and abnormal levels of collagen I, fibronectin, and phosphorylated 5'AMP-activated kinase (p-AMPK), adipose triglyceride lipase (p-ATGL), and HMG-CoA reductase (p-HMGCR) were also observed in diabetic mice. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.038DOI Listing
February 2019

The Case | Posttransplant upper limb inflammatory nodules.

Kidney Int 2019 Mar;95(3):721-722

Department of Kidney Transplantation, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, RTRS "Centaure," Paris, France.

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http://dx.doi.org/10.1016/j.kint.2018.10.012DOI Listing

Giant calcified mass in a hemodialysis patient.

Kidney Int 2019 Mar;95(3):719

Department of Nephrology, Hospital Clínic - IDIBAPS (Institut d'Investigacions Biomèdiques August Pi I Sunyer), University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.08.006DOI Listing

Embedded peritoneal dialysis catheter.

Kidney Int 2019 Mar;95(3):718

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, Florida, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.08.007DOI Listing

The quest for optimal control of relapses in children with nephrotic syndrome.

Kidney Int 2019 Mar;95(3):717

Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.kint.2019.01.002DOI Listing

Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy.

Kidney Int 2019 Mar;95(3):666-679

Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 Valbonne Sophia Antipolis, France. Electronic address:

Autoantibodies against phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type 1 domain-containing 7A (THSD7A) are emerging as biomarkers to classify membranous nephropathy (MN) and to predict outcome or response to treatment. Anti-THSD7A autoantibodies are detected by Western blot and indirect immunofluorescence test (IIFT). Here, we developed a sensitive enzyme-linked immunosorbent assay (ELISA) optimized for quantitative detection of anti-THSD7A autoantibodies. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.024DOI Listing

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics.

Kidney Int 2019 Mar;95(3):624-635

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK; Division of Medicine and Manchester Heart Centre, Manchester University National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms of kidney aging. We sought to define the signatures of age on the renal transcriptome using 563 human kidneys. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.029DOI Listing

Executive summary for the 2015 Annual Data Report of the China Kidney Disease Network (CK-NET).

Kidney Int 2019 Mar;95(3):501-505

Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China.

Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease Network (CK-NET) was initiated in 2014 and further developed in accordance with the national strategy of prompting Big Data application in China. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183081
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http://dx.doi.org/10.1016/j.kint.2018.11.011DOI Listing
March 2019
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The elusive podocyte crossmatch for recurrent focal segmental glomerulosclerosis.

Kidney Int 2019 Mar;95(3):498-500

Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, Miami, Florida, USA; Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA. Electronic address:

Focal segmental glomerulosclerosis is a glomerular disorder with a high rate of recurrence. Although kidney biopsies remain the gold standard to diagnose recurrent focal segmental glomerulosclerosis, non-invasive prognostic assays could facilitate preventive treatments and offer insight into disease pathogenicity and heterogeneity. Srivastava et al. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.032DOI Listing

Renal biopsy findings in patients with extreme obesity: more heterogeneous than you think.

Kidney Int 2019 Mar;95(3):495-498

Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

The number of obese and morbidly obese patients is increasing and so is the burden of renal disease in these patients. In a large series of biopsies from the morbidly obese patient population, Choung et al. show that there is heterogeneity in the renal disease affecting this population. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.008DOI Listing

eGFR conundrum: is this the "truth" or simply another "label"?

Kidney Int 2019 Mar;95(3):494-495

Department of Renal Medicine, Sir Charles Gairdner Hospital, Western Australia, Australia.

Accurate assessment of true kidney function allows early identification, management, and prognostication of persons at risk of having kidney disease. Estimation of glomerular filtration rate using serum creatinine-based equations is frequently used in clinical practice. The majority of these equations are developed in white populations, with very few that are specific to patients of Chinese ethnic backgrounds. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183089
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http://dx.doi.org/10.1016/j.kint.2018.11.022DOI Listing
March 2019
1 Read

Kidney aging: an irresistible slope.

Authors:
Imari Mimura

Kidney Int 2019 Mar;95(3):492-494

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. Electronic address:

Kidney aging is a multifactorial process. Using genome-wide database analysis, Rowland et al. identified testis-specific Y-encoded-like protein 5 as a candidate age-related renal gene, and reported that with aging, testis-specific Y-encoded-like protein 5 expression decreases in response to increased testis-specific Y-encoded-like protein 5 promoter methylation. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.036DOI Listing

DAMPening sterile inflammation of the kidney.

Kidney Int 2019 Mar;95(3):489-491

Institute of Experimental Immunology, University Clinic of Bonn, Rheinische Friedrich Wilhelm University, Bonn, Germany. Electronic address:

Renal ischemia reperfusion injury (IRI) is a serious cause of acute kidney injury (AKI). Danger-associated-molecular pattern molecules (DAMPs) are thought to promote IRI by initiating immune cell infiltration and driving disease progression, but the underlying pathophysiological mechanisms are mainly unclear. Poluzzi et al. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.007DOI Listing

Tubule repair: with a little help from my "unexpected" friends.

Kidney Int 2019 Mar;95(3):487-489

Department of Biomedical Experimental and Clinical Sciences "Mario Serio," University of Florence, Florence, Italy; Excellence Center DENOTHE, University of Florence, Florence, Italy; Nephrology and Dialysis Unit, Meyer Children's University Hospital, Florence, Italy. Electronic address:

Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease. Nakamura and colleagues show that, upon injury, myofibroblasts promote epithelial repair by producing retinoic acid in place of injured tubular cells. These results suggest that resident fibroblasts turning into myofibroblasts maintain a cross-talk that protects tubular epithelial cells from injury and can restore tissue integrity and functionality, challenging the concept that fibrosis is only detrimental in nature. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.019DOI Listing

Beta-blockers for osteoporosis: the sequel.

Kidney Int 2019 Mar;95(3):484-486

Institut National de la Santé et de la Recherche Médicale 1059, Université de Lyon, Saint-Etienne, France. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.01.004DOI Listing

Iron and oxygen sensing: discovering intricate links.

Authors:
Kai-Uwe Eckardt

Kidney Int 2019 Mar;95(3):482-484

Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.01.003DOI Listing

Citius, altius, fortius . . . . faster, higher, stronger.

Kidney Int 2019 Mar;95(3):476-478

The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1016/j.kint.2019.01.001DOI Listing

Predilution online hemodiafiltration is associated with improved survival compared with hemodialysis.

Kidney Int 2019 Feb 16. Epub 2019 Feb 16.

Renal Data Registry Committee, Japanese Society for Dialysis Therapy, Tokyo, Japan; Yabuki Hospital, Yamagata, Japan.

On-line hemodiafiltration is an increasingly common alternative to chronic hemodialysis in some countries, based on the results of randomized controlled trials of post-dilution on-line hemodiafiltration. There are now more than 60,000 patients treated with on-line hemodialfiltration in Japan, over 95% of whom use predilution on-line hemodiafiltration; however, large-scale data on clinical outcomes with this modality are lacking. We created a propensity-matched cohort of 5,000 pairs of patients treated with conventional hemodialysis or predilution on-line hemodiafiltration, using the Japanese Society for Dialysis Therapy Renal Data Registry database from December 31, 2012 to December 31, 2013. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.036DOI Listing
February 2019

Intestinal Toll-like receptor 9 deficiency leads to Paneth cell hyperplasia and exacerbates kidney, intestine, and liver injury after ischemia/reperfusion injury.

Kidney Int 2019 Feb 15. Epub 2019 Feb 15.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York, USA. Electronic address:

Intestinal Paneth cells play a critical role in ischemic acute kidney injury (AKI) by releasing interleukin 17A (IL-17A). Because Toll-like receptor 9 (TLR9) activation degranulates Paneth cells and necrotic tubular epithelial cells release several damage associated molecular patterns that target TLR9, we tested the hypothesis that intestinal TLR9 deficiency would protect against ischemic AKI and associated remote intestinal and hepatic dysfunction by decreasing Paneth cell degranulation. We generated mice lacking TLR9 in intestinal epithelia (TLR9fl/fl Villin Cre mice) and compared them to wild type (TLR9fl/fl) mice following right nephrectomy and left ischemia/reperfusion. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.035DOI Listing
February 2019

Challenges and opportunities for nephrology in Western Europe.

Kidney Int 2019 Feb 16. Epub 2019 Feb 16.

Oxford Kidney Unit and Transplant Centre, Churchill Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.kint.2018.09.028DOI Listing
February 2019

Monogenic causes of chronic kidney disease in adults.

Kidney Int 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Approximately 500 monogenic causes of chronic kidney disease (CKD) have been identified, mainly in pediatric populations. The frequency of monogenic causes among adults with CKD has been less extensively studied. To determine the likelihood of detecting monogenic causes of CKD in adults presenting to nephrology services in Ireland, we conducted whole exome sequencing (WES) in a multi-centre cohort of 114 families including 138 affected individuals with CKD. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.031DOI Listing
February 2019

Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria.

Kidney Int 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

Podocyte injury is the major cause of proteinuria in primary glomerular diseases. Oxidative stress has long been thought to play a role in triggering podocyte damage; however, the underlying mechanism remains poorly understood. Here we show that the Wnt/β-catenin pathway is involved in mediating oxidative stress-induced podocyte dysfunction. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.032DOI Listing
February 2019

Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis.

Kidney Int 2019 Feb 12. Epub 2019 Feb 12.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; CECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. Electronic address:

Recent human genetic studies have suggested an intriguing link between ciliary signaling defects and altered DNA damage responses in nephronophthisis (NPH) and related ciliopathies. However, the molecular mechanism and the role of altered DNA damage response in kidney degeneration and fibrosis have remained elusive. We recently identified the kinase-regulated DNA damage response target Apoptosis Antagonizing Transcription Factor (AATF) as a master regulator of the p53 response. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.034DOI Listing
February 2019
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Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome.

Kidney Int 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

In type 2 cardiorenal syndrome, chronic heart failure is thought to cause or promote chronic kidney disease; however, the underlying mechanisms remain poorly understood. We investigated the role of Wnt signaling in heart and kidney injury in a mouse model of cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC). At 8 weeks after TAC, cardiac hypertrophy, inflammation, and fibrosis were prominent, and echocardiography confirmed impaired cardiac function. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.021DOI Listing
February 2019
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Urinary levels of the leukocyte surface molecule CD11b associate with glomerular inflammation in lupus nephritis.

Kidney Int 2019 Mar 31;95(3):680-692. Epub 2019 Jan 31.

Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

Noninvasive biomarkers of disease activity are needed to monitor response to therapy and predict disease recurrence in patients with glomerulonephritis. The leukocyte surface markers integrin Mac-1 and CD16b have been implicated in the pathogenesis of lupus nephritis (LN). Mac-1 comprises a unique α subunit (CD11b) complexed with a common β2 subunit, which are released along with CD16b from specific leukocyte subsets under inflammatory conditions including glomerulonephritis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183082
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http://dx.doi.org/10.1016/j.kint.2018.10.025DOI Listing
March 2019
3 Reads

A randomized controlled trial of the effect of spironolactone on left ventricular mass in hemodialysis patients.

Kidney Int 2019 Jan 29. Epub 2019 Jan 29.

Comprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany; Department of Medicine I, Division of Nephrology, University Hospital Würzburg, Würzburg, Germany.

Mineralocorticoid receptor antagonists have beneficial effects on left ventricular remodeling, cardiac fibrosis, and arrhythmia in heart failure, but efficacy and safety in dialysis patients is less clear. We evaluated the effect of spironolactone on left ventricular mass (LVM), an independent predictor of all-cause and cardiovascular mortality, in hemodialysis patients. In this placebo-controlled, parallel-group trial, 97 hemodialysis patients (23% female; mean age 60. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.025DOI Listing
January 2019
1 Read

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.

Kidney Int 2019 Mar 31;95(3):540-562. Epub 2019 Jan 31.

Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der JW Goethe-Universität Frankfurt am Main, Frankfurt, Germany. Electronic address:

Biglycan, a small leucine-rich proteoglycan, acts as a danger signal and is classically thought to promote macrophage recruitment via Toll-like receptors (TLR) 2 and 4. We have recently shown that biglycan signaling through TLR 2/4 and the CD14 co-receptor regulates inflammation, suggesting that TLR co-receptors may determine whether biglycan-TLR signaling is pro- or anti-inflammatory. Here, we sought to identify other co-receptors and characterize their impact on biglycan-TLR signaling. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.037DOI Listing

The spectrum of kidney biopsy findings in patients with morbid obesity.

Kidney Int 2019 Mar 31;95(3):647-654. Epub 2019 Jan 31.

Department of Pathology and Cell Biology, Division of Renal Pathology, Columbia University Medical Center, New York, New York, USA. Electronic address:

Morbid obesity, defined as body mass index (BMI) ≥40 kg/m, affects approximately 8% of United States adults and is a recognized risk factor for chronic kidney disease (CKD). We present the first focused biopsy-based study exploring the range of kidney diseases in this population. Among 3263 native kidney biopsies interpreted at Columbia University in 2017, we identified 248 biopsies from morbidly obese patients. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.026DOI Listing
March 2019
1 Read

Costimulatory blockade molecules and B-cell-mediated immune response: current knowledge and perspectives.

Kidney Int 2019 Jan 31. Epub 2019 Jan 31.

Service de Néphrologie et Transplantation, Pôle Cancérologie-Immunité-Transplantation-Infectiologie, Paris-Est Creteil, France; Institut National de la Santé et de la Recherch Médicale, U955, Equipe 21 and Université Paris-Est, Créteil, France. Electronic address:

There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chronic antibody-mediated rejection and allograft loss. In the last decade, both experimental and clinical studies highlighted the major impact of costimulation molecules in the control of immune responses both in the field of transplantation and autoimmune disease. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.028DOI Listing
January 2019

Development and validation of a more accurate estimating equation for glomerular filtration rate in a Chinese population.

Kidney Int 2019 03 29;95(3):636-646. Epub 2019 Jan 29.

Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, China.

Previously published equations to estimate glomerular filtration rate (GFR) have limited accuracy in Asian populations. We aimed to develop and validate a more accurate equation for estimated GFR (eGFR) in the Chinese population, using data from 8571 adults who were referred for direct measurement of GFR by renal dynamic imaging (mGFR) at 3 representative hospitals in China. Patients from the Third Xiangya Hospital were included in our development (n=1730) and internal validation sets (n=1042) and patients from the other hospitals comprised the external validation set (n=5799). Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.019DOI Listing

Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice.

Kidney Int 2019 Mar 30;95(3):590-610. Epub 2019 Jan 30.

Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, USA; Denver VA Medical Center, Division of Nephrology, Department of Medicine, Denver, Colorado, USA. Electronic address:

Acute kidney injury (AKI) is a systemic disease associated with widespread effects on distant organs, including the heart. Normal cardiac function is dependent on constant ATP generation, and the preferred method of energy production is via oxidative phosphorylation. Following direct ischemic cardiac injury, the cardiac metabolome is characterized by inadequate oxidative phosphorylation, increased oxidative stress, and increased alternate energy utilization. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.020DOI Listing
March 2019
1 Read

Development of a novel cell-based assay to diagnose recurrent focal segmental glomerulosclerosis patients.

Kidney Int 2019 Mar 29;95(3):708-716. Epub 2019 Jan 29.

Department of Medicine, Nephrology Division, Medical University of South Carolina, Charleston, South Carolina, USA. Electronic address:

Definitive diagnosis of glomerular disease requires a kidney biopsy, an invasive procedure that may not be safe or feasible to perform in all patients. We developed a noninvasive, accurate, and economical diagnostic assay with easy commercial adaptability to detect recurrent focal segmental glomerulosclerosis (rFSGS) after kidney transplant. Since FSGS involves podocyte damage and death, our approach involved mRNA profiling of cultured podocytes treated with plasma from patients with rFSGS to identify upregulated genes involved in podocyte damage. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.030DOI Listing
March 2019
1 Read

Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?

Kidney Int 2019 Mar 26;95(3):518-525. Epub 2019 Jan 26.

Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland. Electronic address:

Staphylococcus aureus bloodstream infection can have potentially catastrophic consequences for patients on hemodialysis. Consequently, an effective vaccine to prevent S aureus infection would have a significant influence on morbidity and mortality in this group. To date, however, efforts to develop a vaccine have been unsuccessful. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183082
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http://dx.doi.org/10.1016/j.kint.2018.10.023DOI Listing
March 2019
2 Reads

Immunoproteasome inhibition induces plasma cell apoptosis and preserves kidney allografts by activating the unfolded protein response and suppressing plasma cell survival factors.

Kidney Int 2019 Mar 23;95(3):611-623. Epub 2019 Jan 23.

Division of Immunology, Department of Biology, University of Konstanz, Konstanz, Germany; Biotechnology Institute Thurgau at the University of Konstanz, Kreuzlingen, Switzerland. Electronic address:

Chronic antibody-mediated rejection is the leading cause of allograft dysfunction and loss after kidney transplantation, and current immunosuppressive regimens fail to target the plasma cells that produce alloantibodies. We previously showed that treatment with the immunoproteasome inhibitor ONX 0914 prevented the expansion of plasma cells and prevented chronic allograft nephropathy and organ failure after kidney transplantation in rats, but the mechanism has remained elusive. In the current study, we confirmed a long-term reduction in alloantibody production and improvements in allograft histology in rats treated with ONX 0914 or with the broad-spectrum proteasome inhibitor bortezomib. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.022DOI Listing
March 2019
2 Reads
8.563 Impact Factor

Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney.

Kidney Int 2019 Mar 19;95(3):563-576. Epub 2019 Jan 19.

Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia, USA. Electronic address:

The cholinergic anti-inflammatory pathway (CAP) links the nervous and immune systems and modulates innate and adaptive immunity. Activation of the CAP by vagus nerve stimulation exerts protective effects in a wide variety of clinical disorders including rheumatoid arthritis and Crohn's disease, and in murine models of acute kidney injury including ischemia/reperfusion injury (IRI). The canonical CAP pathway involves activation of splenic alpha7-nicotinic acetylcholine receptor (α7nAChR)-positive macrophages by splenic β2-adrenergic receptor-positive CD4+ T cells. Read More

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http://dx.doi.org/10.1016/j.kint.2018.09.020DOI Listing
March 2019
1 Read

The Case | A 78-year-old woman with acute kidney injury and hemolytic anemia.

Kidney Int 2019 Feb;95(2):473-474

Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Friedrich Schiller University, Jena, Germany.

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http://dx.doi.org/10.1016/j.kint.2018.10.013DOI Listing
February 2019
1 Read

Brugada phenocopy induced by hyperkalemia.

Kidney Int 2019 Feb;95(2):471

Renal Division, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.kint.2018.07.014DOI Listing
February 2019
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Paradoxically normal location of peritoneal dialysis catheter.

Kidney Int 2019 Feb;95(2):470

Department of Nephrology and Hypertension, Carmel Medical Center, Haifa, Israel.

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http://dx.doi.org/10.1016/j.kint.2018.07.016DOI Listing
February 2019

The authors reply.

Kidney Int 2019 Feb;95(2):468

Renal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.kint.2018.11.005DOI Listing
February 2019

Proliferative glomerulonephritis with monoclonal Ig deposits (PGNMID): diagnostic and treatment challenges for the nephrologist!

Kidney Int 2019 Feb;95(2):467-468

Department of Nephrology, Hammersmith Hospital, West London Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, UK.

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http://dx.doi.org/10.1016/j.kint.2018.10.016DOI Listing
February 2019

Noninvasive diagnosis of primary membranous nephropathy using phospholipase A2 receptor antibodies.

Kidney Int 2019 Feb;95(2):429-438

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Kidney biopsy is the gold standard to diagnose membranous nephropathy (MN). Approximately 70%-80% of patients with primary MN have anti-phospholipase A2 receptor (PLA2R) antibodies. We hypothesized that PLA2R antibody testing without kidney biopsy may be a valid strategy to make a non-invasive diagnosis of MN in patients with a negative work-up for secondary causes. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.021DOI Listing
February 2019
1 Read

A distinct bone phenotype in ADPKD patients with end-stage renal disease.

Kidney Int 2019 Feb;95(2):412-419

KU Leuven Department of Microbiology and Immunology, Laboratory of Nephrology; University Hospitals Leuven, Department of Nephrology, Leuven, Belgium.

Autosomal dominant polycystic kidney disease (ADPKD) is among the most common hereditary nephropathies. Low bone turnover osteopenia has been reported in mice with conditional deletion of the PKD1 and PKD2 genes in osteoblasts, and preliminary clinical data also suggest suppressed bone turnover in patients with ADPKD. The present study compared the bone phenotype between patients with end stage renal disease (ESRD) due to ADPKD and controls with ESRD due to other causes. Read More

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http://dx.doi.org/10.1016/j.kint.2018.09.018DOI Listing
February 2019
1 Read

Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.

Kidney Int 2019 Feb;95(2):321-332

Division of Nephrology, Department of Medicine, Duke University Health System, Durham, North Carolina, USA; Durham VA Medical Center, Durham, North Carolina, USA. Electronic address:

Gain-of-function mutations in TRPC6 cause familial focal segmental glomerulosclerosis, and TRPC6 is upregulated in glomerular diseases including diabetic kidney disease. We studied the effect of systemic TRPC6 knockout in the Akita model of type 1 diabetes. Knockout of TRPC6 inhibited albuminuria in Akita mice at 12 and 16 weeks of age, but this difference disappeared by 20 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183078
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http://dx.doi.org/10.1016/j.kint.2018.09.026DOI Listing
February 2019
3 Reads

Sodium and water handling during hemodialysis: new pathophysiologic insights and management approaches for improving outcomes in end-stage kidney disease.

Kidney Int 2019 Feb;95(2):296-309

Division of Cardiovascular and Metabolic Disease, Duke-NUS, Singapore; Division of Nephrology, Duke University Medical Center, Durham, North Carolina, USA; Division of Nephrology and Hypertension, University Clinic Erlangen, Germany.

Space medicine and new technology such as magnetic resonance imaging of tissue sodium stores (NaMRI) have changed our understanding of human sodium homeostasis and pathophysiology. It has become evident that body sodium comprises 3 main components. Two compartments have been traditionally recognized, namely one that is circulating and systemically active via its osmotic action, and one slowly exchangeable pool located in the bones. Read More

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http://dx.doi.org/10.1016/j.kint.2018.09.024DOI Listing
February 2019

Management and treatment of glomerular diseases (part 2): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2019 Feb;95(2):281-295

Division of Nephrology, Rheinisch-Westfälische Technische Hochschule, University of Aachen, Aachen, Germany. Electronic address:

In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative brought a diverse panel of experts in glomerular diseases together to discuss the 2012 KDIGO glomerulonephritis guideline in the context of new developments and insights that had occurred over the years since its publication. During this KDIGO Controversies Conference on Glomerular Diseases, the group examined data on disease pathogenesis, biomarkers, and treatments to identify areas of consensus and areas of controversy. This report summarizes the discussions on primary podocytopathies, lupus nephritis, anti-neutrophil cytoplasmic antibody-associated nephritis, complement-mediated kidney diseases, and monoclonal gammopathies of renal significance. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.008DOI Listing
February 2019
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Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2019 Feb;95(2):268-280

Division of Nephrology, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA. Electronic address:

The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a Controversies Conference on glomerular diseases in November 2017. The conference focused on the 2012 KDIGO guideline with the aim of identifying new insights into nomenclature, pathogenesis, diagnostic work-up, and, in particular, therapy of glomerular diseases since the guideline's publication. It was the consensus of the group that most guideline recommendations, in particular those dealing with therapy, will need to be revisited by the guideline-updating Work Group. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.018DOI Listing
February 2019
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Reimagining the kidney biopsy in the era of diagnostic biomarkers of glomerular disease.

Kidney Int 2019 Feb;95(2):265-267

Hospital Fernandez, Buenos Aires, Argentina.

Anti-phospholipase A2 receptor (PLA2R) antibody is a specific biomarker for primary membranous nephropathy (MN). Testing positive for anti-PLA2R has been postulated to establish a diagnosis of MN in the absence of a kidney biopsy. Bobart et al. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.016DOI Listing
February 2019

Uncontrolled DCD donation-tilting at windmills or pushing against an open door?

Kidney Int 2019 Feb;95(2):263-265

Department of Surgery, University of Cambridge, Cambridge, UK. Electronic address:

Wider use of donation after circulatory death donors may increase transplant numbers substantially. Most countries that have adopted donation after circulatory death donation have focused on controlled donation after circulatory death donors, whereby life-supporting treatment is withdrawn in a coordinated manner. In this issue, del Río and colleagues report the Spanish experience for kidneys transplanted from uncontrolled donation after circulatory death donors (typically individuals with sudden cardiorespiratory arrest in the community). Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.018DOI Listing
February 2019
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New pathogenic insights inform therapeutic target development for renal osteodystrophy.

Kidney Int 2019 Feb;95(2):261-263

Department of Medicine Renal Division Washington University School of Medicine, Saint Louis, Missouri, USA; Department of Cell Biology, Washington University School of Medicine, Saint Louis, Missouri, USA.

In an ancillary analysis of cross-sectional observational studies of bone health in end-stage kidney disease (ESKD), Evenepoel et al. reported that subjects with autosomal-dominant polycystic kidney disease (ADPKD) had a unique phenotype in their renal osteodystrophy. ADPKD caused resistance to parathyroid hormone (PTH) producing lower turnover states and preservation of cortical bone mineral density. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183082
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http://dx.doi.org/10.1016/j.kint.2018.10.026DOI Listing
February 2019
5 Reads