19,707 results match your criteria Kidney international[Journal]


Clinicopathological spectrum of renal parenchymal involvement in B-cell lymphoproliferative disorders.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Department of Nephrology and Renal Transplantation, Centre Hospitalier Universitaire, Université de Poitiers, Poitiers, France; CNRS UMR 7276, INSERM UMR 1262, Université de Limoges, Limoges, France; INSERM CIC 1402, Centre Hospitalier Universitaire, Poitiers, France.

The clinicopathological characteristics of kidney infiltration in B-cell lymphoproliferative disorders remain poorly described. We retrospectively studied 52 adults with biopsy-proven malignant B-cell kidney infiltration, including Waldenström's macroglobulinemia (n=21), chronic lymphocytic leukemia (n=11), diffuse large B-cell lymphoma (DLBCL) (n=8), other lymphoma (n=11), and multiple myeloma (n=1). Kidney disease varied according to the underlying lymphoproliferative disorder. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.027DOI Listing

Dialysis initiation, modality choice, access, and prescription: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2019 Apr 12. Epub 2019 Apr 12.

University of Sydney, Sydney, NSW, Australia. Electronic address:

Globally, the number of patients undergoing maintenance dialysis is increasing, yet throughout the world there is significant variability in the practice of initiating dialysis. Factors such as availability of resources, reasons for starting dialysis, timing of dialysis initiation, patient education and preparedness, dialysis modality and access, as well as varied "country-specific" factors significantly affect patient experiences and outcomes. As the burden of end-stage kidney disease (ESKD) has increased globally, there has also been a growing recognition of the importance of patient involvement in determining the goals of care and decisions regarding treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193013
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http://dx.doi.org/10.1016/j.kint.2019.01.017DOI Listing
April 2019
4 Reads

Atypical and secondary hemolytic uremic syndromes have a distinct presentation and no common genetic risk factors.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Centre de Recherche en Transplantation et Immunologie, UMR 1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie, CHU Nantes, Nantes, France; Department of Nephrology and Immunology, Center Hospitalier Universitaire de Nantes, Nantes, France. Electronic address:

Secondary hemolytic uremic syndrome (HUS) is a heterogeneous group of thrombotic microangiopathies associated with various underlying conditions. Whether it belongs to the spectrum of complement-mediated HUS remains controversial. We analysed the presentation, outcome, and frequency of complement gene rare variants in a cohort of 110 patients with secondary HUS attributed to drugs (29%), autoimmune diseases (24%), infections (17%), malignancies (10%), glomerulopathies (9%), extra-renal organ transplantation (8%), and pancreatitis (3%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193016
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http://dx.doi.org/10.1016/j.kint.2019.01.023DOI Listing
March 2019
5 Reads

Tissue inhibitor metalloproteinase-2 (TIMP-2) • IGF-binding protein-7 (IGFBP7) levels are associated with adverse outcomes in patients in the intensive care unit with acute kidney injury.

Kidney Int 2019 Mar 9. Epub 2019 Mar 9.

International Renal Research Institute of Vicenza (IRRIV), San Bortolo Hospital, Vicenza, Italy; Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy; Department of Medicine, University of Padova, Padova, Italy.

The G1 cell cycle inhibitors tissue inhibitor metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been identified as novel biomarkers for the prediction of moderate to severe acute kidney injury (AKI) risk. However, the prognostic value of [TIMP-2]•[IGFBP7] in predicting adverse outcomes in intensive care unit (ICU) patients with AKI was not previously described. To evaluate this, we conducted a cohort study, measuring [TIMP2]•[IGFBP7] levels in critically ill patients admitted to the ICU and classified the patients as NephroCheck (NC) (+) or NC (-) according to [TIMP-2]•[IGFBP7] values and AKI (+) or AKI (-) according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.020DOI Listing

Interleukin-17A blockade reduces albuminuria and kidney injury in an accelerated model of diabetic nephropathy.

Kidney Int 2019 Mar 8. Epub 2019 Mar 8.

Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Diabetic nephropathy (DN) is one of the most common complications of diabetes, and currently the first end-stage renal disease worldwide. New strategies to treat DN using agents that target inflammatory pathways have attracted special interest. Recent pieces of evidences suggest a promising effect of IL-17A, the Th17 effector cytokine. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.031DOI Listing

Big science and big data in nephrology.

Kidney Int 2019 Mar 5. Epub 2019 Mar 5.

RWTH Aachen, Department of Nephrology and Clinical Immunology, Aachen, Germany; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address:

There have been tremendous advances during the last decade in methods for large-scale, high-throughput data generation and in novel computational approaches to analyze these datasets. These advances have had a profound impact on biomedical research and clinical medicine. The field of genomics is rapidly developing toward single-cell analysis, and major advances in proteomics and metabolomics have been made in recent years. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.048DOI Listing

Comprehensive three-dimensional analysis (CUBIC-kidney) visualizes abnormal renal sympathetic nerves after ischemia/reperfusion injury.

Kidney Int 2019 Apr 4. Epub 2019 Apr 4.

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

The sympathetic nervous system is critical in maintaining the homeostasis of renal functions. However, its three-dimensional (3D) structures in the kidney have not been elucidated due to limitation of conventional imaging methods. CUBIC (Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis) is a newly developed tissue-clearing technique, which enables whole-organ 3D imaging without thin-sectioning. Read More

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http://dx.doi.org/10.1016/j.kint.2019.02.011DOI Listing

Mechanisms of GLP-1 receptor-independent renoprotective effects of the dipeptidyl peptidase type 4 inhibitor linagliptin in GLP-1 receptor knockout mice with 5/6 nephrectomy.

Kidney Int 2019 Feb 27. Epub 2019 Feb 27.

Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany; LADR GmbH Neuruppin MVZ, Neuruppin, Germany; Department of Basic Medicine, Medical college of Hunan Normal University, Changsha, China. Electronic address:

Dipeptidyl peptidase type 4 (DPP-4) inhibitors were reported to have beneficial effects in experimental models of chronic kidney disease. The underlying mechanisms are not completely understood. However, these effects could be mediated via the glucagon-like peptide-1 (GLP-1)/GLP-1 receptor (GLP1R) pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193005
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http://dx.doi.org/10.1016/j.kint.2019.01.010DOI Listing
February 2019
2 Reads

Poor accordance to a DASH dietary pattern is associated with higher risk of ESRD among adults with moderate chronic kidney disease and hypertension.

Kidney Int 2019 Mar 4. Epub 2019 Mar 4.

Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, California, USA; Department of Medicine, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.

The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure, an important risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, it is unclear whether adherence to a DASH diet confers protection against future ESRD, especially among those with pre-existing CKD and hypertension. We examined whether a DASH diet is associated with lower risk of ESRD among 1,110 adults aged ≥ 20 years with hypertension and CKD (estimated glomerular filtration rate, eGFR 30-59 ml/min/1. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.027DOI Listing

MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation.

Kidney Int 2019 Mar 5. Epub 2019 Mar 5.

Department of Nephrology, State Key Laboratory of Reproductive Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China. Electronic address:

Mitochondria are critical in determining a cell's energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs that were enriched in the mitochondrial fraction. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.028DOI Listing
March 2019
8.563 Impact Factor

Epitope load identifies kidney transplant recipients at risk of allosensitization following minimization of immunosuppression.

Kidney Int 2019 Mar 5. Epub 2019 Mar 5.

Laboratoire d'Immunologie et Histocompatibilité Hôpital Saint-Louis, Paris, France; INSERM UMRs 1160, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris, France.

Human leukocyte antigen (HLA) mismatching and minimization of immunosuppression are two major risk factors for the development of de novo donor-specific antibodies, which are associated with reduced kidney graft survival. Antibodies do not recognize whole HLA antigens but rather individual epitopes, which are short sequences of amino acids in accessible positions. However, compatibility is still assessed by the simple count of mismatched HLA antigens. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193011
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http://dx.doi.org/10.1016/j.kint.2018.12.029DOI Listing
March 2019
4 Reads

Limited health literacy is associated with reduced access to kidney transplantation.

Kidney Int 2019 Mar 27. Epub 2019 Mar 27.

Academic Unit of Primary Care and Population Sciences, University of Southampton, Southampton, UK.

Limited health literacy is common in patients with chronic kidney disease (CKD) and has been variably associated with adverse clinical outcomes. The prevalence of limited health literacy is lower in kidney transplant recipients than in individuals starting dialysis, suggesting selection of patients with higher health literacy for transplantation. We investigated the relationship between limited health literacy and clinical outcomes, including access to kidney transplantation, in a prospective UK cohort study of 2,274 incident dialysis patients aged 18-75 years. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.021DOI Listing
March 2019
1 Read

CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial cross talk and promotes peritoneal fibrosis.

Kidney Int 2019 Mar 5. Epub 2019 Mar 5.

Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany. Electronic address:

Peritoneal dialysis (PD) is limited by chronic fibrotic remodeling of the peritoneal wall, a transforming growth factor-β (TGF-β)-mediated process. The fractalkine (CX3CL1) receptor CX3CR1 is expressed on macrophages and monocytes, where it is a marker of TGFβ expression. Detection of its ligand CX3CL1 on the peritoneal mesothelium led us to hypothesize a pathophysiologic role of CX3CL1-CX3CR1 interaction in peritoneal fibrosis. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.030DOI Listing

Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis.

Kidney Int 2019 Mar 6. Epub 2019 Mar 6.

Department of Pediatrics, Division of Genetics, University of California, San Diego, La Jolla, California, USA. Electronic address:

Inflammation is involved in the pathogenesis of many disorders. However, the underlying mechanisms are often unknown. Here, we test whether cystinosin, the protein involved in cystinosis, is a critical regulator of galectin-3, a member of the β-galactosidase binding protein family, during inflammation. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.029DOI Listing
March 2019
1 Read

Fluid management in the critically ill.

Kidney Int 2019 Mar 4. Epub 2019 Mar 4.

Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium. Electronic address:

Fluid therapy, which is provided to restore and maintain tissue perfusion, is part of routine management for almost all critically ill patients. However, because either too much or too little fluid can have a negative impact on patient outcomes, fluid administration must be titrated carefully for each patient. The "salvage, optimization, stabilization, de-escalation" (SOSD) mnemonic should be used as a general guide to fluid resuscitation, and fluid administration should be adapted according to the course of the disease. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.047DOI Listing

Long-term trajectory of kidney function in autosomal-dominant polycystic kidney disease.

Kidney Int 2019 Mar 4. Epub 2019 Mar 4.

Legacy Good Samaritan Hospital, Portland, Oregon, USA.

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by cyst and kidney growth, which is hypothesized to cause loss of functioning renal mass and eventually end-stage kidney disease. However, the time course of decline in glomerular filtration rate (GFR) is poorly defined. The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease study is a 14-year observational cohort study of 241 adults with ADPKD. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.023DOI Listing
March 2019
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Multifactorial functions of the inflammasome component NLRP3 in pathogenesis of chronic kidney diseases.

Authors:
Shrikant R Mulay

Kidney Int 2019 Mar 4. Epub 2019 Mar 4.

Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India. Electronic address:

The NLRP3 inflammasome is a cytosolic multiprotein caspase-activating complex platform involved in innate immunity required for the maturation and release of interleukin (IL)-1β and IL-18. Both cytokines activate their respective receptors present on cells inside and outside kidneys, resulting in the release of other proinflammatory cytokines to set up an inflammatory milieu both within the kidney and systemically. The canonical NLRP3-ASC-caspase-1-IL-1β-IL-18 axis has been shown to contribute to the pathophysiology of several kidney diseases by regulating renal necroinflammation. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.014DOI Listing
March 2019
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Innovations in vascular access for hemodialysis.

Kidney Int 2019 Mar 4. Epub 2019 Mar 4.

Department of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian School of Medicine at Seton Hall University, Neptune, New Jersey, USA.

Worldwide, hemodialysis remains the prevalent dialysis modality for more than 2 million patients who require well-functioning vascular access for this procedure. Creation of an arteriovenous fistula for long-term hemodialysis was the first innovation since the Scribner shunt and was followed by the development of an arteriovenous graft and catheter. Bioengineered vessels were developed during the last century, but this field has been energized by recent technology relating to the creation of human vessels. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.046DOI Listing
March 2019
2 Reads

Estimating glomerular filtration rate at the transition from pediatric to adult care.

Kidney Int 2019 Feb 28. Epub 2019 Feb 28.

Nephrology-Dialysis-Transplantation, University of Liège, Centre Hospitalier Universitaire du Sart Tilman, Liège, Belgium.

The current Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend the use of the bedside creatinine-based Chronic Kidney Disease in Children (CKiD) equation to estimate glomerular filtration rate (GFR) in children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in adults. However, this approach causes implausible changes in estimated GFR (eGFR) at the transition from pediatric to adult care. We investigated the performance of the KDIGO strategy and various creatinine-based eGFR equations in a cross-sectional dataset of 5,764 subjects (age 10-30 years), using directly measured GFR (mGFR) as reference. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.020DOI Listing
February 2019
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Bone mineral density, bone turnover markers, and incident fractures in de novo kidney transplant recipients.

Kidney Int 2019 Mar 4. Epub 2019 Mar 4.

Department of Nephrology and Renal Transplantation, University Hospitals Leuven and Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.

Kidney transplant recipients are at increased risk of fractures. This prospective observational study investigated whether areal bone mineral density (aBMD) as assessed by dual-energy x-ray absorptiometry can predict incident fragility fractures in de novo kidney transplant recipients and whether bone turnover markers increase diagnostic accuracy. Parameters of bone mineral metabolism including parathyroid hormone (PTH), fibroblast growth factor 23, sclerostin, calcidiol and calcitriol, and bone turnover markers were assessed in blood samples collected immediately prior to kidney transplantation in 518 adult recipients. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.024DOI Listing
March 2019
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Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome-related factor H mutation.

Kidney Int 2019 Feb 27. Epub 2019 Feb 27.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) caused by dysregulated complement activation. Clinically, aHUS is effectively treated by an anti-C5 monoclonal antibody (mAb) but whether the disease is mediated by the C5a receptor (C5aR) or C5b-9 pathway, or both, is unknown. Here we address this in a factor H mutant mouse (FH) which developed complement-mediated TMA as well as macrovascular thrombosis caused by an aHUS-related factor H point mutation (mouse W1206R, corresponding to human W1183R). Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.009DOI Listing
February 2019
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Performance of creatinine- or cystatin C-based equations to estimate glomerular filtration rate in sub-Saharan African populations.

Kidney Int 2019 Mar 12. Epub 2019 Mar 12.

Division of Nephrology-Dialysis-Transplantation, CHU Sart Tilman (ULg CHU), University of Liège, Liège, Belgium.

Glomerular filtration rate (GFR) is the best index for kidney function; however, the applicability of GFR estimating equations in sub-Saharan African populations remains unclear. In a cross-sectional study of adults living in Kinshasa, Democratic Republic of Congo (n=210) and Abidjan, Ivory Coast (n=284), we evaluated the performance of creatinine and cystatin C-based equations using plasma clearance of iohexol as the reference standard. The race coefficient did not improve the performance of creatinine-based GFR estimates; in fact, both the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology (CKD-EPI) equations performed better without the race coefficient in participants with GFR ≥60 mL/min/1. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.045DOI Listing

Identification of 22 novel loci associated with urinary biomarkers of albumin, sodium, and potassium excretion.

Kidney Int 2019 Mar 12. Epub 2019 Mar 12.

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Electronic address:

Urine biomarkers reflecting kidney function and handling of dietary sodium and potassium are strongly associated with several common diseases including chronic kidney disease, cardiovascular disease, and diabetes mellitus. Knowledge about the genetic determinants of these biomarkers may shed light on pathophysiological mechanisms underlying the development of these diseases. We performed genome-wide association studies of urinary albumin: creatinine ratio (UACR), urinary potassium: creatinine ratio (UK/UCr), urinary sodium: creatinine ratio (UNa/UCr) and urinary sodium: potassium ratio (UNa/UK) in up to 218,450 (discovery) and 109,166 (replication) unrelated individuals of European ancestry from the UK Biobank. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193004
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http://dx.doi.org/10.1016/j.kint.2018.12.017DOI Listing
March 2019
3 Reads

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis.

Kidney Int 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, Augusta University, Augusta, Georgia, USA; Vascular Biology Center, Augusta University, Augusta, Georgia, USA; Department of Pharmacology and Toxicology, Augusta University, Augusta, Georgia, USA. Electronic address:

In mice, the initial stage of nephrotoxic serum-induced nephritis (NTN) mimics antibody-mediated human glomerulonephritis. Local immune deposits generate tumor necrosis factor (TNF), which activates pro-inflammatory pathways in glomerular endothelial cells (GECs) and podocytes. Because TNF receptors mediate antibacterial defense, existing anti-TNF therapies can promote infection; however, we have previously demonstrated that different functional domains of TNF may have opposing effects. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.022DOI Listing
March 2019
1 Read
8.563 Impact Factor

Delayed stricture of irradiated iliac arteries after renal transplantation mimicking transplant renal artery stenosis.

Kidney Int 2019 Apr;95(4):999

Department of Renal Transplantation, Royal Free London NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/j.kint.2018.09.010DOI Listing
April 2019
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Effectiveness and safety of sofosbuvir-based direct-acting antiviral combinations in HCV-2 and HCV-3 kidney transplant recipients.

Kidney Int 2019 Apr;95(4):993-995

CRC "A.M. and A. Migliavacca" Center for Liver Disease, Gastroenterology and Hepatology Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1016/j.kint.2018.11.037DOI Listing

Concerning "Acute kidney injury complicating nephrotic syndrome of minimal change disease".

Kidney Int 2019 Apr;95(4):993

Department of Pathology, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.12.009DOI Listing
April 2019
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The authors reply.

Kidney Int 2019 Apr;95(4):992-993

Aurinia Pharmaceuticals Inc., Victoria Ringgold Standard Institution, Victoria, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.kint.2018.12.010DOI Listing

Data monitoring committees and randomized clinical trials.

Kidney Int 2019 Apr;95(4):992

Department of Population Health, Division of Medical Ethics, NYU Langone Health, NYU, New York, New York, USA.

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http://dx.doi.org/10.1016/j.kint.2018.12.012DOI Listing

Tissue hypoxia, inflammation, and loss of glomerular filtration rate in human atherosclerotic renovascular disease.

Kidney Int 2019 Apr;95(4):948-957

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

The relationships between renal blood flow (RBF), tissue oxygenation, and inflammatory injury in atherosclerotic renovascular disease (ARVD) are poorly understood. We sought to correlate RBF and tissue hypoxia with glomerular filtration rate (GFR) in 48 kidneys from patients with ARVD stratified by single kidney iothalamate GFR (sGFR). Oxygenation was assessed by blood oxygenation level dependent magnetic resonance imaging (BOLD MRI), which provides an index for the levels of deoxyhemoglobin within a defined volume of tissue (R2*). Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.039DOI Listing
April 2019
1 Read
8.563 Impact Factor

Prevalence, incidence, and risk factors for hepatitis C virus infection in hemodialysis patients.

Kidney Int 2019 Apr;95(4):939-947

Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA.

Hepatitis C virus (HCV) infection is common in dialysis patients and is associated with increased morbidity and mortality. We used the Dialysis Outcomes and Practice Patterns Study (DOPPS, 1996-2015) to assess trends in the prevalence, incidence, and risk factors for HCV infection as defined by a documented diagnosis or antibody positivity. Among prevalent hemodialysis patients, HCV prevalence was nearly 10% in 2012-2015. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.038DOI Listing
April 2019
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Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease.

Kidney Int 2019 Apr;95(4):797-814

Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA. Electronic address:

Cisplatin is an effective chemotherapeutic agent, but significant nephrotoxicity limits its clinical use. Despite extensive investigation of the acute cellular and molecular responses to cisplatin, the mechanisms of progression from acute to chronic kidney injury have not been explored. We used functional and morphological metrics to establish a time-point when the transition from acute and reversible kidney injury to chronic and irreparable kidney disease is clearly established. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.042DOI Listing
April 2019
1 Read
8.563 Impact Factor

IgA nephropathy: "State of the art": a report from the 15th International Symposium on IgA Nephropathy celebrating the 50th anniversary of its first description.

Kidney Int 2019 Apr;95(4):750-756

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

On September 27-29, 2018, the International Symposium on IgA Nephropathy, organized by the International IgA Nephropathy Network, was held in Buenos Aires, Argentina, celebrating the 50th anniversary of the first description of IgA nephropathy by Berger and Hinglais in 1968. The meeting was attended by over 200 scientists and clinicians from 26 different countries across the globe. We report some key insights drawn from the meeting-including the molecular pathogenesis, genetics, pathology, and therapeutics of IgA nephropathy. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.007DOI Listing
April 2019
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The safety of mineralocorticoid antagonists in maintenance hemodialysis patients: two steps forward.

Kidney Int 2019 Apr;95(4):747-749

Université de Lorraine, CIC 1433, U 1116, Inserm, CHRU de Nancy, and FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

The Spin-D (Safety and Cardiovascular Efficacy of Spironolactone in Dialysis-Dependent End-Stage Renal Disease) and MiREnDa (Mineralocorticoid Receptor Antagonists in End-Stage Renal Disease) trials taken together provide the reassuring demonstration that up to 25 mg/d spironolactone is reasonably safe, provided maintenance hemodialysis patients are properly monitored and investigators use a per-protocol therapeutic algorithm to manage hyperkalemia. These results should encourage and reassure the investigators of the 2 currently ongoing, large, international, major-outcome clinical trials, both of which are using spironolactone up to 25 mg/d: ACHIEVE (Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease trial; NCT03020303) and ALCHEMIST (ALdosterone antagonist Chronic HEModialysis Interventional Survival Trial; NCT01848639). Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.006DOI Listing
April 2019
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Expanding opportunities and emerging challenges: broadening the scope of genetic testing in nephrology.

Kidney Int 2019 Apr;95(4):743-746

Department of Medicine, Division of Nephrology, Columbia University, New York, New York, USA; Institute for Genomic Medicine, Columbia University, New York, New York, USA. Electronic address:

Massively parallel sequencing technologies such as exome sequencing are increasingly applied across medicine. Connaughton et al. report a high diagnostic yield of exome sequencing among adults with hereditary nephropathy or nephropathy of unknown cause. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.032DOI Listing

Precision nosology versus precision nephrology: defining acute kidney injury, again.

Authors:
Sushrut S Waikar

Kidney Int 2019 Apr;95(4):741-743

Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Consensus definitions for acute kidney injury (AKI) use change in serum creatinine or urine output as the basis for diagnosis and risk stratification. Consensus definitions have been validated largely by prospective associations with in-hospital mortality. Applying this same approach, Sparrow and colleagues propose a further subclassification of stage 1 AKI into 2 subgroups. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.013DOI Listing
April 2019
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Evaluation of living donors: quo vadis for GFR criteria?

Kidney Int 2019 Apr;95(4):738-740

Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. Electronic address:

The evaluation of potential living donors for kidney transplantation is rigorous and is facilitated by guidelines. The assessment of glomerular filtration rate (GFR) is crucial to this process. The methods of ascertaining GFR and thresholds used for determining eligibility of donors are not uniform. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.015DOI Listing

Don't trick me twice!

Kidney Int 2019 Apr;95(4):736-738

Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany. Electronic address:

Chemotherapy-induced nephrotoxicity limits the success of cancer therapy. Landau et al. now describe a mechanism by which a first dose of cisplatin renders the kidney sensitive to necroptosis mediated by a second dose. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.004DOI Listing
April 2019
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A knowledge-guided kidney cell census-reconciling bulk omics with cellular heterogeneity?

Kidney Int 2019 Apr;95(4):733-735

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Systems Biology of Ageing Cologne (Sybacol), University of Cologne, Cologne, Germany. Electronic address:

Clark et al. present a curated knowledge-based census of 43 known canonical kidney cell types, based on calculated contribution to total kidney mass and expression of molecular markers. Their study illustrates limitations of bulk transcriptomics but also provides guidance to their fruitful interpretation. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.016DOI Listing

Placental growth factor in pre-eclampsia: friend or foe?

Authors:
Salem J Almaani

Kidney Int 2019 Apr;95(4):730-732

Department of Medicine, Division of Nephrology; Ohio State University Wexner Medical Center, Columbus, Ohio, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.02.002DOI Listing
April 2019
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High-dose IV iron for anemia correction in chronic kidney disease.

Kidney Int 2019 Apr;95(4):727-730

Inserm U-1018, Team 5, CESP, Hôpital Paul Brousse, Paris-Sud University (UPS), Paris, France; Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France.

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http://dx.doi.org/10.1016/j.kint.2019.01.013DOI Listing
April 2019
2 Reads

The Case | Mass in nonfunctioning first renal allograft in a recipient of 2 transplant kidneys.

Kidney Int 2019 Apr;95(4):1001-1002

Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.11.017DOI Listing

A dialysis patient with isolated persistent left superior vena cava.

Kidney Int 2019 Apr;95(4):1000

Department of Nephrology, Changzheng Hospital, Naval Medical University, Shanghai, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.08.008DOI Listing
April 2019
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Increasing access to integrated ESKD care as part of universal health coverage.

Kidney Int 2019 Apr;95(4S):S1-S33

School of Medicine, Catholic University of Santisima Concepción, Concepcion, Chile.

The global nephrology community recognizes the need for a cohesive strategy to address the growing problem of end-stage kidney disease (ESKD). In March 2018, the International Society of Nephrology hosted a summit on integrated ESKD care, including 92 individuals from around the globe with diverse expertise and professional backgrounds. The attendees were from 41 countries, including 16 participants from 11 low- and lower-middle-income countries. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.005DOI Listing
April 2019
1 Read
8.563 Impact Factor

Health-related quality of life in glomerular disease.

Kidney Int 2019 Feb 27. Epub 2019 Feb 27.

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.018DOI Listing
February 2019
3 Reads

Intensive BP control and incident kidney disease: what can we learn from urinary biomarkers?

Kidney Int 2019 Mar 7. Epub 2019 Mar 7.

Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.kint.2019.02.004DOI Listing

Higher body mass index is associated with incident diabetes and chronic kidney disease independent of genetic confounding.

Kidney Int 2019 Feb 27. Epub 2019 Feb 27.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

It is unknown whether the association between body mass index (BMI) and chronic kidney disease (CKD) is mediated by genetic confounding or obesity-associated diabetes. We investigated the association between BMI and incident CKD in 29,136 Swedish twins with no history of CKD or diabetes, first using traditional Cox regression in a cohort design, and second controlling for shared genetic factors within twin pairs. Hazard ratios (HR) per unit increase in BMI were calculated and adjusted for age, sex, comorbidities, and lifestyle factors. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.019DOI Listing
February 2019
1 Read