821,247 results match your criteria Kidney international[Journal]


The renoprotective effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on adenine-induced kidney disease in rats.

Biomed Pharmacother 2018 Dec 12;110:667-676. Epub 2018 Dec 12.

Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, 123, Oman.

We assessed the effect of treatment with the dipeptidyl peptidase-4 inhibitor, sitagliptin, on adenine-induced chronic kidney disease (CKD). Six equal groups of rats were given either normal food or food mixed with adenine (0.25% w/w for five weeks) to induce CKD. Read More

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December 2018

Comparison of fatigue, pain and depression in patients with advanced kidney disease and cancer - symptom burden and clusters.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA.

Context: While symptom clusters have been studied in the context of cancer, few data exist in chronic and end stage kidney disease (CKD/ESKD) patients.

Objectives: To (1) characterize and compare symptom cluster phenotypes in patients with advanced CKD, ESKD and cancer, and (2) explore predictors of symptom clusters.

Methods: We conducted secondary data analysis of three prospective studies in which pain, depression, and fatigue were assessed in patients with stage 4-5 CKD, ESKD and gastrointestinal (GI) cancer. Read More

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December 2018

Focal Ablative Therapy for Renal Cell Carcinoma in Transplant Allograft Kidneys.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Objectives: To evaluate outcomes after focal ablative therapy for renal cell carcinoma (RCC) in transplant allograft kidneys METHODS: After institutional review board approval, patients with a history of RCC in a transplanted allograft kidney who underwent focal ablative therapy were identified. Complete chart reviews were performed and the relevant data were extracted for cumulative analysis.

Results: Six patients were treated with focal ablative therapy for RCC in a transplanted allograft kidney at our institutional between 2010-2017. Read More

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December 2018

Lower incidence of de novo donor-specific antibodies against HLA-DR in ABO-incompatible renal transplantation.

Hum Immunol 2018 Dec 12. Epub 2018 Dec 12.

Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. Electronic address:

Recently, in vitro experiments have demonstrated that anti-blood group A/B antibody binding to endothelial cells induce a protective effect against antibody-mediated injury. This study aimed to clarify the potential clinical benefit of ABO incompatibility in donor-specific HLA antibody (DSA)-induced chronic antibody-mediated rejection (ABMR). We enrolled 215 ABO-incompatible renal transplant (ABO-I) and 467 ABO-identical/compatible renal transplant recipients (ABO-Id/C). Read More

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December 2018

EDITORIAL COMMENT.

Urology 2018 Dec;122:49-50

Center for Urologic Oncology, Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, OH.

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December 2018

EDITORIAL COMMENT.

Urology 2018 Dec;122:42

Center for Urologic Oncology, Glickman Urologic and Kidney Institute, Cleveland Clinic.

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December 2018

Calcitriol loading before total parathyroidectomy with autotransplant in patients with end stage kidney disease: Does it prevent postoperative hypocalcaemia?

Intern Med J 2018 Dec 15. Epub 2018 Dec 15.

Endocrine and General Surgery, Department of Surgery, John Hunter Hospital and Newcastle Private Hospital, Lookout Road New Lambton Heights, New South Wales, Australia, 2305.

Background: Hungry bone syndrome (HBS) is one of the most serious complications following parathyroidectomy for severe hyperparathyroidism. There is a lack of literature informing the treatment and risk factors for this condition and the ideal pre-operative strategy for prevention.

Aims: The primary aims of this study were to examine the incidence of HBS with pre-operative calcitriol loading for 10 days and to determine the risk factors for HBS. Read More

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December 2018

Parents' experiences of donation to their child before kidney transplantation: A qualitative study.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Institute, University of Southern, Denmark.

Aim And Objectives: To explore Parents' experiences of donation to their child before kidney transplantation.

Background: Transplantation is the treatment of choice for pediatric patients with end-stage renal disease. Living donor kidney transplantation has shown a higher long-term transplant survival compared to deceased donor transplantation and entails a more controllable process, with shorter waiting time. Read More

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December 2018

A population pharmacokinetic model to predict the individual starting dose of tacrolimus in adult renal transplant recipients.

Br J Clin Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Aims: The aims of this study were to describe the pharmacokinetics of tacrolimus immediately after kidney transplantation, and to develop a clinical tool for selecting the best starting dose for each patient.

Methods: Data on tacrolimus exposure were collected for the first three months following renal transplantation. A population pharmacokinetic analysis was conducted using nonlinear mixed-effects modeling (NONMEM). Read More

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December 2018

Surgical outcomes of acute type A aortic dissection in dialysis patients.

Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanumacho, Omiya-ku, Saitama, 330-8503, Japan.

Background: Acute type A aortic dissection (ATAAD) is relatively uncommon in dialysis patients, and characteristics and repair outcomes are not fully understood.

Patients And Methods: Patients with ATAAD (n = 960) were divided into a dialysis group (n = 19) and non-dialysis group (n = 941), depending on whether they required dialysis for preoperative end-stage renal disease (ESRD). Hospital charts and imaging data were reviewed, and characteristics and outcomes were compared between the groups. Read More

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December 2018

Impact of medication therapy management on pharmacotherapy safety in an intensive care unit.

Int J Clin Pharm 2018 Dec 15. Epub 2018 Dec 15.

Laboratório de Pesquisa em Ensino e Serviços de Saúde (LaPESS), Faculdade de Farmácia, Universidade Federal de Goiás - UFG, 240th street corner of 5th Avenue, Goiânia, GO, 74650-170, Brazil.

Background Drug-related problems are mostly preventable or predictable circumstances that may impact on health outcomes. Clinical pharmacy activities such as medication therapy management can identify and solve these problems, with potential to improve medication safety and effectiveness. Objective To evaluate ability of medication therapy management service to detect drug-related problems and prevent adverse drug events. Read More

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December 2018

Pharmacokinetics of Prolonged-Release Once-Daily Formulations of Tacrolimus in De Novo Kidney Transplant Recipients: A Randomized, Parallel-Group, Open-Label, Multicenter Study.

Adv Ther 2018 Dec 14. Epub 2018 Dec 14.

Service de Néphrologie, Dialyse, Aphérèses et Transplantation, CHU Grenoble Alpes, Grenoble, France.

Introduction: Different prolonged-release formulations of tacrolimus are available. To date, the pharmacokinetic (PK) profile of LCP-tacrolimus (LCPT; Envarsus) has not been compared with PR-Tac (Advagraf) in de novo kidney transplant recipients. These profiles will guide clinical recommendations for the initiation and dose titration strategies of once-daily tacrolimus formulations. Read More

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December 2018

What's new in autoinflammation?

Authors:
Seza Ozen

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Hacettepe University, Ankara, Turkey.

The pathogenesis of autoinflammatory diseases has shed light on the concept of inflammation in general and on our understanding of the role of the innate immune system. The autoinflammatory diseases have a large spectrum with varying features of inflammation. The most common autoinflammatory diseases are those associated with periodic fevers. Read More

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December 2018

Growth plate alterations in chronic kidney disease.

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Division of Pediatrics, Department of Medicine, Faculty of Medicine, University of Oviedo, CP 33006, Oviedo, Asturias, Spain.

Growth retardation is a major feature of chronic kidney disease (CKD) of onset in infants or children and is associated with increased morbidity and mortality. Several factors have been shown to play a causal role in the growth impairment of CKD. All these factors interfere with growth by disturbing the normal physiology of the growth plate of long bones. Read More

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December 2018
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Out-of-home informal support important for medication adherence, diabetes distress, hemoglobin A1c among adults with type 2 diabetes.

J Behav Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA.

Adults with type 2 diabetes mellitus (T2DM) often receive self-management support from adult children, siblings or close friends residing outside of their home. However, the role of out-of-home support in patients' self-management and well-being is unclear. Patients (N = 313) with HbA1c > 7. Read More

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December 2018

Heller myotomy is the optimal index procedure for esophageal achalasia in adolescents and young adults.

Surg Endosc 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

Background: There is limited and conflicting data on the optimal intervention for the treatment of achalasia in adolescents and young adults (AYA), Heller myotomy (HM), esophageal dilation (ED) or botulinum toxin injection (botox). The goal of this study is to determine the most appropriate index intervention for achalasia in the AYA population.

Methods: We completed a longitudinal, population-based analysis of the California (2005-2010) and New York (1999-2014) statewide databases. Read More

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December 2018

Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues.

Arch Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

Exposure to environmental chemicals has been shown to have an impact on the epigenome. One example is a known human carcinogen 1,3-butadiene which acts primarily by a genotoxic mechanism, but also disrupts the chromatin structure by altering patterns of cytosine DNA methylation and histone modifications. Sex-specific differences in 1,3-butadiene-induced genotoxicity and carcinogenicity are well established; however, it remains unknown whether 1,3-butadiene-associated epigenetic alterations are also sex dependent. Read More

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December 2018

Juvenile dermatomyositis with IgA nephropathy: case-based review.

Rheumatol Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Juvenile dermatomyositis (JDM) is the most common childhood idiopathic inflammatory myopathy (IIM). It is characterized by the classic skin rash in the form of Gottron papules and heliotrope rash, and symmetric proximal muscle weakness. Renal involvement in JDM is rare which includes acute kidney injury and glomerulonephritis. Read More

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December 2018
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Pediatric percutaneous renal biopsies: comparison of complications between real-time ultrasound guidance and pre-procedure ultrasound-aided skin-marking techniques.

Pediatr Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Texas Children's Hospital, 6701 Fannin St., #470, Houston, TX, 77030, USA.

Background: Percutaneous renal biopsy is a commonly performed procedure that guides decision-making for children with renal disease.

Objective: To compare complications from renal biopsies using real-time ultrasound (US) guidance versus pre-procedure US-aided skin-marking in children.

Materials And Methods: We conducted a priori power analysis using a risk-adjusted model, which indicated we needed a sample size of 643-714 procedures (effect size: 0. Read More

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December 2018
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Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury.

Sci Rep 2018 Dec 14;8(1):17870. Epub 2018 Dec 14.

UW Medicine South Lake Union, University of Washington, Seattle, WA, 98109, USA.

Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered early and late phases of a pathologic continuum of interconnected disease states. Although changes in gene expression patterns have recently been elucidated for the transition of AKI to CKD, the epigenetic regulation of key kidney injury related genes remains poorly understood. We used multiplex RT-qPCR, ChIP-qPCR and integrative analysis to compare transcriptional and epigenetic changes at renal disease-associated genes across mouse AKI and CKD models. Read More

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December 2018

Connectivity of the Superficial Muscles of the Human Perineum: A Diffusion Tensor Imaging-Based Global Tractography Study.

Sci Rep 2018 Dec 14;8(1):17867. Epub 2018 Dec 14.

Department of Bioengineering, Medicine & Radiology, University of California, San Diego, CA, USA.

Despite the importance of pelvic floor muscles, significant controversy still exists about the true structural details of these muscles. We provide an objective analysis of the architecture and orientation of the superficial muscles of the perineum using a novel approach. Magnetic Resonance Diffusion Tensor Images (MR-DTI) were acquired in 10 healthy asymptomatic nulliparous women, and 4 healthy males. Read More

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December 2018
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Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, uromodulin, and cystatin C concentrations in an experimental rat model of ascending acute kidney injury induced by pyelonephritis.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Department of Pathophysiology, Jagiellonian University Medical College, Cracow, Poland.

Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), cystatin C (CysC), uromodulin (UMOD), and some interleukins (IL-6 and IL-18) can be considered as diagnostic markers of acute kidney injury (AKI). The aim of this study was to verify the applicability of four urinary (u) markers, namely uNGAL, uKIM-1, uCysC, and uUMOD, for the diagnosis of ascending AKI induced by bacterial pyelonephritis. The study included 30 female rats that were divided into three groups (n = 10 each) and were inoculated transurethrally with various doses of Escherichia coli to induce isolated pyelonephritis (group 1, 10 CFU/ml), pyelonephritis-induced AKI (group 2, 10 CFU/ml), or AKI and urosepsis (group 3, 10 CFU/ml). Read More

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Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study.

BMJ Open 2018 Dec 14;8(12):e020759. Epub 2018 Dec 14.

Center of Biotechnology, Khalifa University, Abu Dhabi, United Arab Emirates.

Objectives: Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.

Research Design And Methods: Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Read More

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December 2018

Albumin-Binding PSMA Ligands: Implications for Expanding the Therapeutic Window.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Weill Cornell Medicine, United States.

Despite significant gains in the treatment of metastatic castration-resistant prostate cancer by radioligands targeting PSMA, 30% of patients never respond to therapy. One possible explanation is insufficient dose delivery to the tumor, which is related to suboptimal pharmacokinetics. We have recently described RPS-063, a trifunctional ligand targeting PSMA with high uptake in LNCaP xenograft tumors, but also in kidneys. Read More

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December 2018

Parathyroid carcinoma.

Best Pract Res Clin Endocrinol Metab 2018 Dec 1. Epub 2018 Dec 1.

Departments of Laboratory Medicine and Pathobiology, Medicine and Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Parathyroid carcinoma (PC) is a rare disease with an indolent behavior due to the low malignant potential. The etiology is unknown. Somatic mutations of CDC73 gene, the same gene involved in the hyperparathyroidism-jaw tumor syndrome, can be identified in up to 70% of patients with PC and in one-third of cases the mutations are germline. Read More

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December 2018

HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation.

Kidney Int 2018 Dec 7. Epub 2018 Dec 7.

Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu. Electronic address:

Hypoxia promotes tubulointerstitial inflammation in the kidney. Although hypoxia inducible factor-1α (HIF-1α) is a master regulator of the response to hypoxia, the exact mechanisms through which HIF-1α modulates the induction of tubulointerstitial inflammation are still largely unclear. We demonstrated tubulointerstitial inflammation and increased tubular HIF-1α expression in murine models of ischemia/reperfusion injury and unilateral ureteral obstruction. Read More

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December 2018

Recurrent Acute Kidney Injury: Can We Differentiate From Nonrecovery and CKD Progression?

Am J Kidney Dis 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, University of California San Diego, San Diego, CA. Electronic address:

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December 2018

Can immune biomarkers predict infections in solid organ transplant recipients? A review of current evidence.

Transplant Rev (Orlando) 2018 Oct 9. Epub 2018 Oct 9.

Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Australia; Department of Nephrology, Monash Medical Centre, Clayton, Victoria 3168, Australia. Electronic address:

Despite improvements in graft survival, solid organ transplantation is still associated with considerable infection induced morbidity and mortality. If we were able to show that serious infection risk was associated with excessive suppression of immune capacity, we would be justified in "personalizing" the extent of immunosuppression by carefully monitored reduction to see if we can improve immune compromize without increasing the risk of rejection. Reliable biomarkers are needed to identify this patients at an increased risk of infection. Read More

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October 2018

Candida albicans.

Authors:
Duncan Wilson

Trends Microbiol 2018 Dec 11. Epub 2018 Dec 11.

Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, Aberdeen, UK. Electronic address:

Pathogens often face zinc restriction due to the action of nutritional immunity - host processes which restrict microbial access to key micronutrients such as zinc and iron. Candida albicans scavenges environmental zinc via two pathways. The plasma membrane transporter Zrt2 is essential for zinc uptake and growth in acidic environments. Read More

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December 2018

A Polysaccharide Purified from Prevents Oxidative Stress Induced by H₂O₂ in Human Embryonic Kidney (HEK) 293T Cells.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

College of Food Science and Engineering, Jilin University, Changchun 130062, China.

() has been used both as a medical and edible mushroom and possesses antimicrobial properties and antioxidant activities. However, the antioxidant properties of polysaccharides purified from have not been studied. The aim of this study was to investigate the in vitro antioxidant properties of a polysaccharide NMCP-2 (neutral polysaccharides-2) purified from as determined by radical scavenging assay and H₂O₂-induced oxidative stress in HEK 293T cells. Read More

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December 2018

Comparison of antidiabetic effects of saponins and polysaccharides from Momordica charantia L. in STZ-induced type 2 diabetic mice.

Biomed Pharmacother 2019 Jan 5;109:744-750. Epub 2018 Nov 5.

Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Department of Biology, College of Science, Shantou University, Shantou, Guangdong 515063, PR China. Electronic address:

Saponins as small organic molecules and polysaccharides as biomacromolecules are the main bioactive substances of Momordica charantia L. (M. charantia) with anti-hyperglycemic activities. Read More

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January 2019
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Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo.

Biomed Pharmacother 2019 Jan 30;109:2375-2386. Epub 2018 Nov 30.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Triptolide (TP) has an anti-proteinuric effect and is used for the treatment of podocytopathies. TP has also been shown to act directly on immortalized podocytes in culture to protect them from injury. In the present study, we examined the effect of TP on healthy podocytes both in vitro and in vivo to better understand the action of TP on podocytes. Read More

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January 2019

Alpinia oxyphylla oil induces apoptosis of hepatocellular carcinoma cells via PI3K/Akt pathway in vitro and in vivo.

Biomed Pharmacother 2019 Jan 30;109:2365-2374. Epub 2018 Nov 30.

Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China. Electronic address:

Background: The anti-tumor properties of Alpinia oxyphylla Miquel (A. oxyphylla) extracts and their petroleum ether (PE) fractions have long attracted scientific attention. These extracts' anti-tumor activity and mechanisms in vivo are still unclear. Read More

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January 2019
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Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway.

Biomed Pharmacother 2019 Jan 29;109:2309-2317. Epub 2018 Nov 29.

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118 China. Electronic address:

Cisplatin, as an effective chemotherapeutic agent, is widely used to treat verious types of cancers. Nephrotoxicity induced by cisplatin seriously limits its clinical application. Icariin, a major and remarkable flavonoid isolated from Epimedium koreanum, has been reported to exert anti-oxidative stress and anti-inflammation actions. Read More

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January 2019
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Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model.

Biomed Pharmacother 2019 Jan 28;109:2285-2292. Epub 2018 Nov 28.

Institute of Microbiology, University of Agriculture, Faisalabad, 38040, Pakistan.

Cinnamomum zeylanicum, a widely used spice and flavor, is used in the treatment and prevention of many diseases. In the current study, Balb/c mice were pretreated with cinnamon bark aqueous extract (200 mg/kg/day i.g. Read More

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January 2019

Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy.

Biomed Pharmacother 2019 Jan 26;109:1802-1808. Epub 2018 Nov 26.

Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Accumulating evidences indicated that hyperuricemia was an independent risk factor for kidney diseases and contributed to kidney fibrosis. Preventing and treating renal fibrosis was an optimal treatment for hyperuricemia-induced kidney diseases. In the study, pterostilbene (PTE) as a bioactive component of blueberries was confirmed to possess lowering serum uric acid and renal protective functions by the decrease of serum creatinine, BUN, urine albumin, and urine albumin-to-creatinine ratio (uACR) in a mouse model of hyperuricemic nephropathy (HN). Read More

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January 2019

Piperlongumine, a piper alkaloid targets Ras/PI3K/Akt/mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH/DSS induced experimental colon cancer.

Biomed Pharmacother 2019 Jan 13;109:1462-1477. Epub 2018 Nov 13.

Department of Biochemistry Basic Medical Science Block-II Sector-25, South Campus, Panjab University, Chandigarh 160014, India. Electronic address:

Colorectal cancer (CRC) is the most common carcinoma of the digestive tract. The slow growing nature of CRC offers a great opportunity for prevention strategies. The concept of chemoprevention of colorectal cancer using plant derived natural products is gaining substantial attention because it is an inherently safe and cost-effective alternative to conventional cancer therapies. Read More

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January 2019
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Zhen-wu-tang attenuates Adriamycin-induced nephropathy via regulating AQP2 and miR-92b.

Biomed Pharmacother 2019 Jan 9;109:1296-1305. Epub 2018 Nov 9.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address:

Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia and edema. The disorder of sodium and water metabolism is a critical mechanism regulating the origination and progression of NS. Zhen-wu-tang (ZWT) has been traditionally used to treat edema disease in China and Japan. Read More

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January 2019

Effect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes.

Biomed Pharmacother 2019 Jan 7;109:1206-1210. Epub 2018 Nov 7.

Eskisehir Osmangazi University, Medicine Faculty, Department of Biostatistics, Eskisehir, Turkey.

Objective Non-alcoholic fatty liver disease, steatohepatitis and nephropathy are considered among the most important complications of diabetes mellitus (DM), which recently increased due to increased frequency of DM and the prolonged life span of diabetic patients The aim of the present study was to reveal the possible effect of hesperidin (HP) on alpha-klotho (α-KL)/ fibroblast growth factor-23 (FGF-23) pathway in rats with diabetes induced by streptozotocin (STZ). Materials and methods Thirty six male Sprague-Dawley rats were randomly divided into three groups. The rats of the control, diabetes, and treatment groups were fed with standard feed and water throughout the 2-week study. Read More

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January 2019

Mechanistic role of cAMP and hepatocyte growth factor signaling in thioacetamide-induced nephrotoxicity: Unraveling the role of platelet rich plasma.

Biomed Pharmacother 2019 Jan 6;109:1078-1084. Epub 2018 Nov 6.

Biochemistry Department, Faculty of Pharmacy and Drug Manufacturing, Pharos University, Alexandria, Egypt.

Chronic kidney diseases occur as result of exposure to wide range of deleterious agents as environmental pollutants, toxins and drug. Currently, there is no effective protective therapy against renal damage, fibrosis and its sequel of end stage renal disease. Platelet-rich plasma (PRP) has a progressively gained consideration in wound healing, repair/regeneration of damaged tissues and conservation of organ function. Read More

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January 2019

SARS, MERS and coronavirus infections.

Authors:
Akihiko Kawana

Nihon Rinsho 2016 Dec;74(12):1967-1972

The human coronavirus (HCoV) contains HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV- HKU1, SARS-CoV and MERS-CoV. HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1 are pathogens of common cold. During 2002-2003, a new coronavirus, the SARS-CoV, was found to be the cause of an acute, severe frequently fatal respiratory disease with prominent systemic symptoms (severe acute respiratory syndrome). Read More

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December 2016

The New Kidney Allocation System: The First 18 Months.

Authors:
Linda S Wright

Nephrol Nurs J 2016 Nov-Dec;43(6):527-534

Clinical Manager of Abdominal Organ Transplant, Thomas Jefferson University Hospital, Philadelphia, PA.

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December 2018

Responses to a Survey on the Perceived Barriers to Effective Discharge Planning in Renal Transplant Recipients.

Authors:
Keeley Haas

Nephrol Nurs J 2016 Nov-Dec;43(6):521-525

Pulmonary Critical Care Nurse Practitioner, Veterans Affairs Hospital, Orlando, FL.

This process improvement project identified variables that interfere with a patient's timely discharge after a kidney transplant. Expert transplant clinicians employed by 10 large transplant centers were surveyed regarding variables that contribute most to an extended length of stay. Although statistically significant results were not obtained, some important clinical trends were apparent. Read More

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December 2018

Knowledge and Awareness Among Patients with Chronic Kidney Disease Stage 3.

Nephrol Nurs J 2016 Nov-Dec;43(6):513-519

Assistant Professor of Clinical Medicine, Indiana University, Indianapolis, IN.

Knowledge is a prerequisite for changing behavior, and is useful for improving outcomes and reducing mortality rates in patients diagnosed with chronic kidney disease (CKD). The purpose of this article is to describe baseline CKD knowledge and awareness obtained as part of a larger study testing the feasibility of a self-management intervention. Thirty patients were recruited who had CKD Stage 3 with coexisting diabetes and hypertension. Read More

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December 2018

The Evaluation of an Orientation Program of Self-Care Abilities for Patients on Hemodialysis.

Nephrol Nurs J 2016 Nov-Dec;43(6):501-534

Clinical Nurse Educator, Hemodialysis Unit, Providence Health Care, Vancouver, British Columbia, Canada.

Effective management of end stage renal disease for individuals undergoing hemodialysis (HD) requires the acquisition of self-care abilities, which have been shown to improve outcomes. Studies have indicated that educational interventions improve self-care abilities in patients with chronic kidney failure. A self-care coaching intervention was designed to bridge this gap. Read More

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December 2018

Decisional Needs Assessment to Help Patients with Advanced Chronic Kidney Disease Make Better Dialysis Choices.

Nephrol Nurs J 2016 Nov-Dec;43(6):463-493

Emeritus Professor Faculty of Health Sciences, University of Ottawa, Ottawa, Canada.

Patients with advanced chronic kidney disease (CKD) face many choices regarding future dialysis modalities. Decision-making is difficult for patients. The objective of this study was to describe the decision-making needs from the perspectives of patients with advanced CKD, professionals, and others involved in the decision. Read More

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December 2018

In Patients with Chronic Kidney Disease, There Is No Such Thing as 'Stable'.

Authors:
Candice Halinski

Nephrol Nurs J 2016 Sep-Oct;43(5):445-446

Director, Service Line-Clinical, Division of Nephrology, Northwell Health, Manhasset, NY.

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December 2018

Peritoneal Dialysis Catheter Obstruction by Uterine Tubaric Fimbriae in an Adult Woman with Developmental Abnormalities.

Nephrol Nurs J 2016 Sep-Oct;43(5):439-441

Professor of Nephrology, University of Pavia, Chief of Unit of Nephrology, Dialysis and Transplant, Fondazione IRCCS Policlinico, San Matteo, Pavia. Italy.

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December 2018
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The Relationship of the Spiritual and Religious Dimensions with Quality of Life and Health of Patients with Chronic Kidney Disease: An Integrative Literature Review.

Nephrol Nurs J 2016 Sep-Oct;43(5):411-426

Professor, University of São Paulo, Ribeirão Preto College of Nursing, Ribeirão Preto, São Paulo, Brazil.

An integrative literature review examining the relationship of the spiritual and religious dimensions in quality of life (QoL) to the health of patients with chronic kidney disease was conducted. Questions included: "What is the relationship of the religious and spiritual dimension with QoL and health of people with chronic kidney disease (CKD)?" and "How does religious and spiritual coping influence the patient with CKD?" From the studies selected for review, it appears patients' spiritual and religious dimensions can positively influence the patients' QoL, increase their survival rate, and improve their health status. Read More

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December 2018

Over-the-Counter Drugs to Avoid in Older Adults with Kidney Impairment.

Nephrol Nurs J 2016 Sep-Oct;43(5):389-400

Associate Professor, University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO.

Older adults (age 65 years or older) are at especially high risk of having adverse events from over-the-counter (OTC) drugs, and older adults who have kidney disease are at an even higher risk. These older adults with kidney impairment may need to completely avoid, or at the least reduce, their exposure to certain OTC products, such as nonsteroidal inhibitors. When older adults with kidney impairment are counseled about the safety of OTC drugs, they need to be made aware that some drugs may also require dose adjustments. Read More

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December 2018
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