21,669 results match your criteria Kidney Trauma


Page kidney phenomenon in kidney allograft following abdominal trauma.

Urol Case Rep 2020 Sep 23;32:101274. Epub 2020 May 23.

University of Utah School of Medicine, Department of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, USA.

The page kidney phenomenon is often associated in patients with abdominal trauma. External compression from a renal hematoma can cause hypertension, and presentation can be delayed following the initial injury. For patients who have a kidney allograft, page kidneys may lead to renal insufficiency and acute renal failure due to the absence of a contralateral kidney to compensate. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260421PMC
September 2020

Cisplatin-induced renal toxicity in elderly people.

Ther Adv Med Oncol 2020 18;12:1758835920923430. Epub 2020 May 18.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.

Despite available prevention and treatment measures, such as hydration, diuresis, magnesium supplementation, and amifostine, renal toxicity is still one of the major dose-limiting side effects of cisplatin. The aim of this review is to discuss the issue of cisplatin-induced nephrotoxicity in the elderly. Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, and survival time may be decreased. Read More

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http://dx.doi.org/10.1177/1758835920923430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238313PMC

β1-Blocker improves survival and ventricular remodelling in rats with lethal crush injury.

Eur J Trauma Emerg Surg 2020 Jun 2. Epub 2020 Jun 2.

Institute of Disaster Medicine, Tianjin University, Tianjin, 300072, China.

Background: Crush injury/crush syndrome (CI/CS) is the second most common cause of death during earthquakes. Most studies of CI/CS have mainly focused on kidney injury after decompression. Few studies have focused on myocardial injury caused by crush injury and its potential mechanisms. Read More

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http://dx.doi.org/10.1007/s00068-020-01408-yDOI Listing

The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction.

Biomed Pharmacother 2020 May 30;128:110259. Epub 2020 May 30.

Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.

Moringa Oleifera (MO) is a herbal plant native to South Asia known for its anti-oxidative and anti-inflammatory properties. This study explored the protective effects of MO leaf extract (MOLE) against oxidative stress and hepatic and renal injuries caused by methotrexate (MTX) therapy. Mice received a single intraperitoneal injection of 20 mg/kg body weight MTX to induce hepatic and kidney injuries. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110259DOI Listing

Atraumatic splenic rupture in a patient treated with apixaban: A case report.

Int J Surg Case Rep 2020 May 11;71:270-273. Epub 2020 May 11.

Sir Charles Gairdner Hospital, General Surgery - Western Australia Liver and Kidney (WALK), WA, Australia.

Introduction: Splenic rupture is often seen in the context of significant trauma. Atraumatic ruptures are described in the context of malignancy, inflammation or infection directly affecting the spleen. Splenic ruptures occurring in patients taking apixaban, a factor Xa inhibitor, are challenging due to the scarcity of a direct reversal agent. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.050DOI Listing

Mob Justice in South Africa: A comparison of blunt trauma secondary to community and non-community assaults.

Injury 2020 May 22. Epub 2020 May 22.

University of KwaZulu Natal, Pietermaritzburg, KwaZulu Natal, South Africa; University of Witwatersrand, Johannesburg, Gauteng, South Africa. Electronic address:

Background: The phenomenon of extrajudicial "mob justice" and community assault (CA) has been documented in news reports and anecdotes from a number of low- and middle-income countries, but there is little literature on its burden on trauma systems. This study reviews a single center's management of CA victims and compares the spectrum of injuries seen following mob assault with those sustained via other forms of interpersonal violence (IPV).

Methods: Clinical data, injury details, and mortality among injured patients (age≥18) hospitalized in a South African tertiary referral center from 2012-2018 were abstracted. Read More

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http://dx.doi.org/10.1016/j.injury.2020.04.014DOI Listing

Organ injury scaling 2018 update: spleen, liver and kidney.

Authors:
Ballari Sanjay

J Trauma Acute Care Surg 2020 May 27. Epub 2020 May 27.

Resident, Department of Radiodiagnosis.

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http://dx.doi.org/10.1097/TA.0000000000002821DOI Listing

Determination of arsenicals in mouse tissues after simulated exposure to arsenic from rice for sixteen weeks and the effects on histopathological features.

Ecotoxicol Environ Saf 2020 May 26;200:110742. Epub 2020 May 26.

Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China. Electronic address:

The accumulation of arsenic in rice has become a worldwide concern. In this study, dose-dependency in tissues (intestine, liver and kidney) and blood distribution of inorganic arsenicals and their methylated metabolites were investigated in male C57BL/6 mice exposed to four arsenic species (arsenite [iAs], arsenate [iAs], monomethylarsonate [MMA], and dimethylarsinate [DMA]) at four doses (control [C]: 0 μg/g, simulation [S]: 0.91 μg/g, medium [M]: 9. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110742DOI Listing

Contribution of Bone Tissue to Regulation of Calcium and Phosphate Metabolism. Role of FGF23 and Klotho Protein.

Ortop Traumatol Rehabil 2020 Apr;22(2):69-76

Klinika Ortopedii z Pododdziałem Ortopedii Dziecięcej, Centralny Szpital Kliniczny Uniwersytetu Medycznego w Łodzi, Polska / Department of Orthopaedics with Paediatric Orthopaedics Ward, Central Teaching Hospital of the Medical University of Lodz, Poland.

Bone tissue actively contributes to the regulation of systemic homoeostasis, and particularly the maintenance of calcium-phosphate balance. The parathyroid hormone-vitamin D feedback axis is balanced by the recently discovered bone-FGF23-kidney hormonal axis. An active complex consisting of FGF23, a receptor and Klotho protein blocks phosphate reabsorption in the proximal tubules, increasing urine phosphate levels and decreasing blood phosphate levels. Read More

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http://dx.doi.org/10.5604/01.3001.0014.1153DOI Listing

Severe Kidney Injury After a 110-km Trail Race.

Authors:
Volker Scheer

Cureus 2020 Apr 24;12(4):e7814. Epub 2020 Apr 24.

Sports Medicine, Ultra Sports Science Foundation, Pierre-Benite, FRA.

We present a case of severe, acute kidney injury, rhabdomyolysis and dehydration in a 49-year-old, competitive trail runner, after a 110-km trail race in mountainous terrain. Six days after the event, he presented to the hospital with fatigue, weight gain and oedema. Biochemically the diagnosis of severe, acute kidney injury was made, with increased serum creatinine levels of 13. Read More

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http://dx.doi.org/10.7759/cureus.7814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249747PMC

Vasopressor selection during critical care management of brain dead organ donors and the effects on kidney graft function.

J Trauma Acute Care Surg 2020 Jun;88(6):783-788

From the Medical Scientist Training Program (E.A.S.), Oregon Health and Science University, Portland, Oregon; Department of Surgery (M.S.P.), Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada; Surgical Critical Care Section (T.G., N.E.J., M.K.M.E., M.P.H., D.J.M., M.B.S.), Veterans Affairs Portland Health Care System; Department of Anesthesiology and Perioperative Medicine (M.K.M.E.), Oregon Health and Science University, Portland, Oregon; Department of Anesthesia and Perioperative Care (C.U.N.), University of California San Francisco, San Francisco, California; and Department of Surgery (D.J.M., M.B.S.), Oregon Health and Science University, Portland, Oregon.

Background: Delayed graft function (DGF), the need for dialysis in the first week following kidney transplant, affects approximately one quarter of deceased-donor kidney transplant recipients. Donor demographics, donor serum creatinine, and graft cold ischemia time are associated with DGF. However, there is no consensus on the optimal management of hemodynamic instability in organ donors after brain death (DBDs). Read More

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http://dx.doi.org/10.1097/TA.0000000000002688DOI Listing

Small bowel stenosis after blunt abdominal trauma: a case report.

Surg Case Rep 2020 May 26;6(1):115. Epub 2020 May 26.

Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8503, Japan.

Background: Small bowel stenosis after blunt abdominal trauma is relatively rare, and progression from trauma to bowel stenosis might sometimes be delayed. Herein, we report the case of a patient who was diagnosed with small bowel stenosis relatively early and received laparoscopic surgery.

Case Presentation: An 18-year-old Japanese male was in a traffic accident and was urgently transported to our hospital. Read More

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http://dx.doi.org/10.1186/s40792-020-00874-1DOI Listing

Double Ureter: Incidence, Types, and Its Applied Significance-A Cadaveric Study.

Cureus 2020 Apr 21;12(4):e7760. Epub 2020 Apr 21.

Anatomy, Chettinad Hospital and Research Institute, Chennai, IND.

Introduction Congenital ureter anomalies such as double ureters are uncommon developmental anomalies of the renal system. An abnormal branching pattern of ureteric bud results in the formation of double ureter. This study examined the incidence of double ureter in cadavers of a South Indian population. Read More

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http://dx.doi.org/10.7759/cureus.7760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243094PMC

Subcapsular Renal Hematoma in Simultaneous Pancreas Kidney Transplantation.

Case Rep Transplant 2020 11;2020:6152035. Epub 2020 May 11.

Department of Clinical and Experimental Medicine, Division of Metabolism and Cell Transplantation, University of Pisa, Pisa, Italy.

Subcapsular renal hematoma (SRH) is a challenging condition, which may jeopardize kidney function or constitute a life-threatening event. This is particularly true in single-kidney patients, such as kidney-transplant recipients. SRH may exert an excessive pressure on the surrounding parenchyma, thus resulting in hypoperfusion and ischemia, with high risk of acute kidney failure and graft loss. Read More

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http://dx.doi.org/10.1155/2020/6152035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238346PMC

The role of uric acid in inflammasome-mediated kidney injury.

Curr Opin Nephrol Hypertens 2020 Jul;29(4):423-431

Nephrology Division, Federal University of São Paulo.

Purpose Of Review: Uric acid is produced after purine nucleotide degradation, upon xanthine oxidase catalytic action. In the evolutionary process, humans lost uricase, an enzyme that converts uric acid into allantoin, resulting in increased serum uric acid levels that may vary according to dietary ingestion, pathological conditions, and other factors. Despite the controversy over the inflammatory role of uric acid in its soluble form, crystals of uric acid are able to activate the NLRP3 inflammasome in different tissues. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000619DOI Listing

Galectins as potential pharmacological targets in renal injuries of diverse etiology.

Eur J Pharmacol 2020 May 22:173213. Epub 2020 May 22.

Neurology Department, China-Japan Union Hospital of Jilin University, Changchun, 130000, PR China. Electronic address:

Galectins are carbohydrate-binding proteins, and their importance in renal diseases of diverse etiology has been documented. Amongst different galectins, the role of galectin-3 in the pathophysiology of renal diseases has been well documented. There is an increase in galectin-3 in the circulation as well as on the kidneys in chronic kidney disease patients. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173213DOI Listing

Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis.

Eur J Trauma Emerg Surg 2020 May 24. Epub 2020 May 24.

Division of Trauma, Burns, Surgical Critical Care and Acute Care Surgery, Department of Surgery, Irvine Medical Center, University of California, 333 The City Blvd West, Suite 1600, Orange, CA, 92868-3298, USA.

Background: Given the growing number of people worldwide living with huma immunodeficiency virus (HIV), a larger subset of these patients are now susceptible to sustaining a traumatic injury. However, the impact of HIV on outcomes in trauma with modern antiretroviral treatment remains unclear. We hypothesized mortality and rates of infectious and inflammatory complications would be higher in HIV positive (HIV+) trauma patients. Read More

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http://dx.doi.org/10.1007/s00068-020-01402-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246034PMC

Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

Kidney Int 2020 May 21. Epub 2020 May 21.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

A wide spectrum of immunological functions has been attributed to Interleukin 9 (IL-9), including effects on the survival and proliferation of immune and parenchymal cells. In; recent years, emerging evidence suggests that IL-9 expression can promote tissue repair in; inflammatory conditions. However, data about the involvement of IL-9 in kidney tissue protection is very limited. Read More

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http://dx.doi.org/10.1016/j.kint.2020.04.036DOI Listing

Renal ultrasound to evaluate for blunt renal trauma in children: A retrospective comparison to contrast enhanced CT imaging.

J Pediatr Urol 2020 Apr 29. Epub 2020 Apr 29.

University of Texas Southwestern Department of Urology, USA. Electronic address:

Introduction: The standard imaging modality for hemodynamically stable blunt abdominal trauma patients is a contrast enhanced CT scan, which is reflected in the current AUA urotrauma guidelines. This comes, however, with radiation exposure and the potential sequalae of IV contrast administration in the pediatric patient.

Objective: We hypothesize that ultrasound imaging would be able to diagnose and rule out clinically significant renal injuries when compared to the gold standard of CT scan in the setting of pediatric blunt abdominal trauma. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.04.020DOI Listing

Evaluation of biomarkers for prediction of drug-induced nephrotoxicity in RPTEC/TERT1 cells.

Toxicol Res (Camb) 2020 Apr 24;9(2):91-100. Epub 2020 Apr 24.

Chinese Academy of Medical Sciences & Peking Union Medical College, No. 9, Dongdan Santiao, Dongcheng District, Beijing 100730, China.

There have been intensive efforts to identify biomarkers that can be used to monitor drug-induced kidney damage before significant impairment occurs. Kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, clusterin, β2-microglobulin and cystatin C (CysC) have been validated as clinical or preclinical biomarkers in urinary and plasma predictive of acute and chronic kidney injuries and diseases. A high-throughput assay predictive of nephrotoxicity could potentially be implemented in early drug discovery stage to reduce attrition at later stages of drug development. Read More

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http://dx.doi.org/10.1093/toxres/tfaa005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232964PMC

Cardiovascular Manifestation and Treatment in COVID-19.

J Chin Med Assoc 2020 May 18. Epub 2020 May 18.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

The novel coronavirus disease 2019 (COVID-19), with first presentation of atypical pneumonia, has spread rapidly from Wuhan, China on December 12, 2019 to over 200 countries, caused 2310572 infected individuals and 158691 mortalities, updated on 2020/4/19. Many studies have published timely to help global health-care workers to understand and control the disease. Vulnerable patients with risk factors such as elderly, cardiovascular diseases (e. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000352DOI Listing

Overexpression of HOXA-AS2 inhibits inflammation and apoptosis in podocytes via sponging miRNA-302b-3p to upregulate TIMP3.

Authors:
X Li H-M Yu

Eur Rev Med Pharmacol Sci 2020 May;24(9):4963-4970

Department of Thoracic Surgery, Zhejiang Putuo Hospital, Zhoushan, China.

Objective: To clarify the role of HOXA-AS2 in the progression of diabetic nephropathy (DN) and the molecular mechanism.

Materials And Methods: Relative levels of HOXA-AS2 and microRNA-302b-3p (miRNA-302b-3p) in serum and kidney tissues of DN rats induced by STZ administration and controls were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Serum levels of interleukin-1β (IL-1β), Transforming Growth Factor-α (TNF-α), creatinine, and BUN, as well as blood glucose in DN rats administrated with vector or pcDNA-HOXA-AS2 lentivirus, were detected. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21187DOI Listing

Serial hemoglobin monitoring in adult patients with blunt solid organ injury: less is more.

Trauma Surg Acute Care Open 2020 14;5(1):e000446. Epub 2020 May 14.

Surgery, University of Florida College of Medicine, Jacksonville, Florida, USA.

Background: Patients who sustain blunt solid organ injury to the liver, spleen, or kidney and are treated nonoperatively frequently undergo serial monitoring of their hemoglobin (Hb). We hypothesized that among initially hemodynamically stable patients with blunt splenic, hepatic, or renal injuries treated without an operation, scheduled monitoring of serum Hb values may be unnecessary as hemodynamic instability, not merely Hb drop, would prompt intervention.

Methods: We performed a retrospective review of patients admitted to our urban Level 1 trauma center following blunt trauma with any grade III, IV, or V liver, spleen, or kidney injury from January 1, 2016 to December 31, 2016. Read More

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http://dx.doi.org/10.1136/tsaco-2020-000446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232739PMC

Predictors of Augmented Renal Clearance in a Heterogeneous ICU Population as Defined by Creatinine and Cystatin C.

Nephron 2020 May 19:1-8. Epub 2020 May 19.

Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: The incidence of augmented renal clearance (ARC) in the intensive care unit (ICU) is highly variable, and identification of these patients remains challenging.

Objective: The objective of this study was to define the incidence of ARC in a cohort of critically ill adults, using serum Cr and cystatin C, and to identify factors associated with its development.

Methods: This is a retrospective cohort study of critically ill patients without stage 2 or 3 acute kidney injury with both serum Cr and cystatin C available. Read More

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http://dx.doi.org/10.1159/000507255DOI Listing

A "crush" course on rhabdomyolysis: risk stratification and clinical management update for the perioperative clinician.

J Anesth 2020 May 18. Epub 2020 May 18.

Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Boston, MA, 02111, USA.

Rhabdomyolysis, the release of myoglobin and other cellular breakdown products from necrotic muscle tissue, is seen in patients with crush injuries, drug overdose, malignant hyperthermia, muscular dystrophy, and with increasing frequency in obese patients undergoing routine procedures. For the perioperative clinician, managing the resultant shock, hyperkalemia, acidosis, and myoglobinuric acute kidney injury can present a significant challenge. Prompt recognition, hydration, and correction of metabolic disturbances may reduce or eliminate the need for long-term renal replacement therapy. Read More

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http://dx.doi.org/10.1007/s00540-020-02792-wDOI Listing

Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.

J Physiol Biochem 2020 May 18. Epub 2020 May 18.

Department of Central Laboratory, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China.

The epithelial-to-mesenchymal transition (EMT)-based tubulointerstitial fibrosis is the major pathological feature of diabetic kidney disease (DKD). While several studies have linked cell cycle dysregulation to various kidney injuries in recent years, its involvement in fibrosis of DKD is far from being clarified. ING2 (inhibitor of growth 2) is the second member of the inhibitor of growth family and participates in the regulation of many cellular processes. Read More

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http://dx.doi.org/10.1007/s13105-020-00743-3DOI Listing
May 2020
1.969 Impact Factor

Interleukin-36β activates autophagy of CD4+CD25+ regulatory T cells and inhibits its immunosuppressive activity in sepsis.

J Infect Dis 2020 May 18. Epub 2020 May 18.

Department of General Intensive Care Unit, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Background: CD4+CD25+ regulatory T cells (Tregs) play an essential role in sepsis-induced immunosuppression. How, the effects of interleukin (IL)-36 cytokines on CD4+CD25+ Tregs and their underlying mechanism(s) in sepsis remain unknown.

Methods: Our study was designed to investigate the impacts of IL-36 cytokines on murine CD4+CD25+ Tregs in presence of lipopolysaccharide (LPS) and in a mouse model of sepsis induced by caecal ligation and puncture (CLP). Read More

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http://dx.doi.org/10.1093/infdis/jiaa258DOI Listing

Esculin reduces P2X7 and reverses mitochondrial dysfunction in the renal cortex of diabetic rats.

Life Sci 2020 May 14;254:117787. Epub 2020 May 14.

Translational Medicine, Universidade Federal de Sao Paulo (UNIFESP-EPM), Brazil; Laboratory of Nitric Oxide and Oxidative Stress, Universidade Federal de Sao Paulo (UNIFESP-EPM), Brazil; Nephrology Division, Universidade Federal de Sao Paulo (UNIFESP-EPM), Brazil; Emergency Division, Universidade Federal de Sao Paulo (UNIFESP-EPM), Brazil.

Aims: To evaluate the effects of esculin treatment on P2X7 receptor and mitochondrial dysfunction in the renal cortex of diabetic rats.

Main Methods: Male Wistar rats, 7 weeks old, were unilaterally nephrectomized. Part of these animals were induced to diabetes using streptozotocin (60 mg/kg). Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117787DOI Listing

Free DNA, a reason for severe COVID-19 infection?

Authors:
Bin Liu

Med Hypotheses 2020 May 5;142:109812. Epub 2020 May 5.

Department of Biobank, Shenzhen Baoan Women's and Children's Hospital, Jinan University, 56 Yulv Road, Baoan District, Shenzhen 518102, Guangdong, China. Electronic address:

The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. However, the etiology of severe COVID-19 has been largely unknown. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199685PMC

Molecular Mechanism of Mesenchyme Homeobox 1 in Transforming Growth Factor β1-Induced Gene Transcription in Fibrosis.

Front Mol Biosci 2020 28;7:59. Epub 2020 Apr 28.

Institute of Burn Research, PLA, State Key Laboratory of Trauma, Burn and Combined Injury, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.

Organ fibrosis is characterized by excessive fibroblast, and extracellular matrix and the molecular basis are not fully elucidated. Recent studies have proven that P311, an 8-kDa conserved protein, could promote various organ fibrosis, such as skin, kidney, liver, and lung, partially through upregulating transforming growth factor β1 (TGF-β1) translation. However, the upstream regulators and mechanism of P311 gene regulation remain unclear, although we previously found that cytokines, hypoxia, and TGF-β1 could upregulate P311 transcription. Read More

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http://dx.doi.org/10.3389/fmolb.2020.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199492PMC

Traumatic renal artery pseudoaneurysm on a pelvic kidney.

J Med Vasc 2020 May 27;45(3):158-160. Epub 2020 Mar 27.

Mohammed V University, Rabat, Morocco; Department of Urology A, CHU Ibn Sina, 10104 Souissi, Rabat, Morocco.

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http://dx.doi.org/10.1016/j.jdmv.2020.03.003DOI Listing

The inhibition of eIF5A hypusination by GC7, a preconditioning protocol to prevent brain death-induced renal injuries in a preclinical porcine kidney transplantation model.

Am J Transplant 2020 May 13. Epub 2020 May 13.

INSERM, UMR-1082 IRTOMIT, Poitiers, F-86021, France.

The eIF5A hypusination inhibitor GC7 (N1-guanyl-1,7-diaminoheptane) was shown to protect from ischemic injuries. We hypothesized that GC7 could be useful for preconditioning kidneys from donors prior transplantation. Using a preclinical porcine brain-death (BD) donation model, we carried out in vivo evaluation of GC7 pre-treatment (3 mg/kg iv, 5 min after BD) at the beginning of the 4h-donor management, after which kidneys were collected, cold-stored (18h in UW) and one was allo-transplanted. Read More

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http://dx.doi.org/10.1111/ajt.15994DOI Listing

Effects and Mechanism of lncRNA CRNDE on Sepsis-Induced Acute Kidney Injury.

Anal Cell Pathol (Amst) 2020 1;2020:8576234. Epub 2020 May 1.

Department of Emergency, Shanghai Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China 200011.

Objective: To investigate the effects of lncRNA CRNDE on sepsis-associated acute kidney injury in the human kidney 2 cell line and explore the potential mechanisms.

Methods: HK-2 cells were treated with lipopolysaccharides to induce injuries. The expression of CRNDE and miR-146a in HK-2 cells were altered by a transient transfection assay. Read More

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http://dx.doi.org/10.1155/2020/8576234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211233PMC

Lactoferrin Contributes a Renoprotective Effect in Acute Kidney Injury and Early Renal Fibrosis.

Pharmaceutics 2020 May 8;12(5). Epub 2020 May 8.

Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.

Patients with acute kidney injury (AKI) who survive the acute stage are at notable risk for chronic kidney disease (CKD) progression. There is no single therapy that can effectively prevent the AKI to CKD transition. Autophagy is a cytoplasmic component degradation pathway and has complex functions in several diseases, such as renal fibrosis. Read More

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http://dx.doi.org/10.3390/pharmaceutics12050434DOI Listing

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries.

Redox Rep 2020 Dec;25(1):51-58

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

This study explores the protective role of losartan (LT) against oxidative and inflammatory damages in different physiological systems including heart, liver, and kidney tissue in hypercholesterolemic rats. After induction of hypercholesterolemia by high cholesterol diet for 6 weeks, LT was administered for 4 weeks. In serum, the levels of lipoproteins, aminotransferases, creatine kinases, urea, apoptosis, and inflammatory markers were measured. Read More

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http://dx.doi.org/10.1080/13510002.2020.1763714DOI Listing
December 2020
1.522 Impact Factor

Hyperkalemia mimicking brugada pattern in electrocardiogram: A rare case report from Nepal.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):524-527

Department of Cardiology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.

Hyperkalemia is one of the dangerous complications of renal impairment (acute kidney injury or chronic kidney disease). Hyperkalemia may present with the electrocardiogram (ECG) changes as nonspecific repolarization abnormalities. Here, we report a case of AKI with hyperkalemia and the Brugada pattern of ECG, which reverted to normal after effective management of hyperkalemia. Read More

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http://dx.doi.org/10.4103/1319-2442.284030DOI Listing

Pregnancy-related acute kidney injury and urological comorbidities in morbidly adherent placenta: A potential challenge to AKI-0by25.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):368-379

Department of Nephrology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Pregnancy-related acute kidney injury (PRAKI) and urological complications can significantly increase the maternal morbidity and mortality, and morbidly adherent placenta (MAP) has been found to increase the risk of both. This is a four-year prospective study, conducted on patients with MAP. Baseline parameters (demographic/antenatal/perinatal), operative details (obstetric/urological/hemostatic), peri-operative complications (AKI/urological), and maternal/fetal outcomes were studied till six weeks after delivery. Read More

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http://dx.doi.org/10.4103/1319-2442.284011DOI Listing

Effect of Shenfu Injection on Porcine Renal Function after Cardiopulmonary Resuscitation.

Evid Based Complement Alternat Med 2020 22;2020:3789268. Epub 2020 Apr 22.

Shengli Clinical Medical College, Fujian Medical University, Fuzhou 350001, China.

Objective: To comprehensively evaluate the protective effect of Shenfu injection (SFI) on renal ischaemia/reperfusion injury (IRI) after cardiopulmonary resuscitation (CPR) through neutrophil gelatinase-associated lipocalin (NGAL) and to explore effective monitoring of early renal injuries after CPR.

Methods: Thirty healthy minipigs were randomly divided into 3 groups: sham operation (SO) ( = 6), control ( = 12), and SFI ( = 12). The SO group underwent only catheterization, whereas the control and SFI groups were subjected to program-controlled electrical stimulation to establish a cardiac arrest (CA) model due to ventricular fibrillation. Read More

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http://dx.doi.org/10.1155/2020/3789268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193270PMC

[Single-Incision Laparoscopic Colectomy for Descending Colon Cancer in a Patient with a Horseshoe Kidney].

Gan To Kagaku Ryoho 2020 Feb;47(2):301-303

Dept. of Gastroenterological Surgery, Osaka Police Hospital.

A 67-year-old woman presented with bloody stools to a local physician. Lower gastrointestinal endoscopy revealed a type 3 all-circumferential tumor at descending colon. She was diagnosed with descending colon cancer and referred to our hospital for surgery. Read More

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February 2020

Traumatic hip fracture and primary elective total hip patients are not the same: A comparison of comorbidity burden, hospital course, postoperative complications and cost of care analysis.

J Orthop Trauma 2020 May 4. Epub 2020 May 4.

University of Arizona College of Medicine Phoenix, Department of Orthopaedic Surgery, Phoenix, AZ.

Objectives: To compare patient admission comorbidity profiles, length of stay, readmission rate, postoperative complications, mortality rate and cost of care between acute geriatric hip fractures (HF) and elective total hip arthroplasties (THA) METHODS:: Retrospective Cohort SETTING:: Multi-center healthcare system PATIENTS:: 18,042 geriatric hip fractures treated with operative fixation or arthroplasty and 8,761 elective total hip patients were reviewed MAIN OUTCOME MEASUREMENTS:: Charlson Comorbidty Index, length of stay, ICU admission, readmission rate, postoperative complications, mortality rates and cost of care RESULTS:: Medical comorbidities: chronic pulmonary disease, chronic kidney disease, coronary artery disease, heart failure, liver cirrhosis, and cerebrovascular disease were higher in HF patients as was mean Charlson Comorbidity Index (p<0.001). Albumin was lower and HgbA1c higher in HF patients (p<0. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001800DOI Listing

Postmortem Computed Tomography and Magnetic Resonance Imaging of an Abdominal Gunshot Wound.

Am J Forensic Med Pathol 2020 Jun;41(2):119-123

From the Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Zurich.

The use of postmortem computed tomography (CT) has been described in many articles concerning gunshot injuries. Postmortem magnetic resonance imaging (MRI) for better assessment of soft tissue injuries has also been mentioned in the literature, albeit much less often. The use of postmortem MRI for abdominal gunshot wounds has not been previously presented in the literature. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000547DOI Listing

[Report on management of severe renal trauma.]

Arch Esp Urol 2020 May;73(4):274-280

Departamento de Cirugía. Sección de Urología Universidad del Valle. Cali. Colombia. Profesor Escuela de Medicina. Universidad del Valle. Cali. Colombia.

Objective: To characterize the clinical condition, the type of therapeutic approach and outcome of patients with severe renal trauma (AAST: 4 and 5) treated in a tertiary hospital. Cali, Colombia.

Methods: A descriptive observational study was conducted with patients older than 15 years treated between January 1, 2015 and January 1, 2019, with a diagnosis of renal trauma and renal vessel trauma. Read More

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Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis.

Research (Wash D C) 2020 19;2020:2402961. Epub 2020 Apr 19.

The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.

The recent outbreak of COVID-19 has been rapidly spreading on a global scale. To date, there is no specific vaccine against the causative virus, SARS-CoV-2, nor is there an effective medicine for treating COVID-19, thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19. By extracting and analyzing all available published clinical data, we identified several major clinical characteristics associated with increased disease severity and mortality among patients with COVID-19. Read More

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http://dx.doi.org/10.34133/2020/2402961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187729PMC

Polybrominated diphenyl ethers and decabromodiphenyl ethane in paired hair/serum and nail/serum from corresponding chemical manufacturing workers and their correlations to thyroid hormones, liver and kidney injury markers.

Sci Total Environ 2020 Aug 28;729:139049. Epub 2020 Apr 28.

School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China. Electronic address:

We detected the polybrominated diphenyl ethers (PBDEs) or decabromodiphenyl ethane (DBDPE) in paired hair-serum and nail-serum samples collected from the corresponding chemical manufacturing workers. The levels of decabrominated diphenyl ether (BDE-209) or DBDPE in the serum, hair and nail samples were all significantly higher than those reported in other studies, and the "work place" (pretreatment or posttreatment workshop) was the primary influencing factor that affected the levels of specific BFRs in vivo. For BDE-209 workers, the BDE-209 in both the hair and nail samples were significantly and positively related to the BDE-209 in the serum, indicating that both hair and nails can be used as noninvasive biomatrices to reflect internal exposure to BDE-209. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139049DOI Listing

Estimating the potential pool of uncontrolled DCD donors in the United States.

Am J Transplant 2020 May 5. Epub 2020 May 5.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Organs from uncontrolled DCD donors (uDCDs) have expanded donation in Europe since the 1980s, but are seldom used in the United States. Cited barriers include lack of knowledge about the potential donor pool, lack of robust outcomes data, lack of standard donor eligibility criteria and preservation methods, and logistical and ethical challenges. To determine whether it would be appropriate to invest in addressing these barriers and building this practice, we sought to enumerate the potential pool of uDCD donors. Read More

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http://dx.doi.org/10.1111/ajt.15981DOI Listing

Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study.

Signal Transduct Target Ther 2020 05 5;5(1):62. Epub 2020 May 5.

Department of Emergency Medicine and Laboratory of Emergency Medicine, Deep Underground Space Medical Center, Disaster Medical Center, West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1038/s41392-020-0163-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198844PMC

Oridonin Alleviates IRI-Induced Kidney Injury by Inhibiting Inflammatory Response of Macrophages via AKT-Related Pathways.

Med Sci Monit 2020 May 4;26:e921114. Epub 2020 May 4.

Research Center of Combine Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China (mainland).

BACKGROUND Acute kidney injury (AKI) is one of the most common complications in clinic, but there is still no effective treatment. Oridonin, extracted from Rabdosia rubescens, has been identified to promote inhibitory effects on tumor, inflammatory and fibrosis by previous study. This study aimed to assess the kidney-protective role of Oridonin in AKI and the underlying mechanism by which Oridonin improves AKI in vivo and inhibits inflammation in LPS-induced bone marrow-derived macrophages (BMDM) in vitro. Read More

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http://dx.doi.org/10.12659/MSM.921114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219002PMC

Physical effects of sound exposure from underwater explosions on Pacific sardines (Sardinops sagax).

J Acoust Soc Am 2020 Apr;147(4):2383

University of Maryland, College Park, Maryland 20742, USA.

Explosions from activities such as construction, demolition, and military activities are increasingly encountered in the underwater soundscape. However, there are few scientifically rigorous data on the effects of underwater explosions on aquatic animals, including fishes. Thus, there is a need for data on potential effects on fishes collected simultaneously with data on the received signal characteristics that result in those effects. Read More

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http://dx.doi.org/10.1121/10.0001064DOI Listing

Pre-operative Renal Artery Embolization in Laparoscopic Radical and Partial Nephrectomy: A Multidisciplinary Approach to Renal Tumors.

Surg Technol Int 2020 May;36:23-28

Department of Surgery, S. Andrea Hospital, La Spezia, Italy, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.

Background: Despite being widely adopted, the laparoscopic approach to radical and partial nephrectomy is still burdened by high rates of hemorrhagic complications, which require blood transfusions and conversion to open surgery with increased morbidity. While pre-operative renal artery embolization (PRAE) can prevent intraoperative blood loss and vascular injuries, its prophylactic use is still a matter of debate. This study evaluated the safety and efficacy of PRAE in overcoming the main pitfalls of laparoscopy, which are related to the absence of tactile feedback. Read More

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