20,529 results match your criteria Kidney Trauma


Laparoscopy First Approach in Acute Care Surgery.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Introduction: The use of laparoscopic management as a first choice for the treatment of duodenal perforation is gaining ground but is not routine in many centers. In this report we aim to report our experience with laparoscopy as the first approach for the repair of duodenal perforation.

Materials And Methods: This is a retrospective review of patients during our initial experience with the use of laparoscopy for the treatment of duodenal perforation between 2009 and 2013. Read More

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http://dx.doi.org/10.1159/000500107DOI Listing
April 2019
2 Reads

Characteristics of Nonpulmonary Organ Dysfunction at Onset of ARDS Based on the Berlin Definition.

Respir Care 2019 Apr 16. Epub 2019 Apr 16.

Department of Pulmonary and Critical Care Medicine, University of California, San Francisco at San Francisco General Hospital, San Francisco, California.

Background: The Berlin definition of ARDS does not account for nonpulmonary organ failure, which is a major determinant of outcome. We examined whether an increasing severity of hypoxemia across the Berlin definition classifications also corresponded with evidence of multiple organ dysfunction on the day of ARDS onset. We also examined the representation of major etiologies for ARDS across the Berlin definition classifications. Read More

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http://rc.rcjournal.com/lookup/doi/10.4187/respcare.06165
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http://dx.doi.org/10.4187/respcare.06165DOI Listing
April 2019
2 Reads

Acute Tubular Injury is Associated With Severe Traumatic Brain Injury: in Vitro Study on Human Tubular Epithelial Cells.

Sci Rep 2019 Apr 15;9(1):6090. Epub 2019 Apr 15.

Department of Anesthesia and Intensive Care, University of Turin, Città della Salute e della Scienza - Molinette University Hospital, Turin, Italy.

Acute kidney injury following traumatic brain injury is associated with poor outcome. We investigated in vitro the effects of plasma of brain injured patients with acute tubular kidney injury on kidney tubular epithelial cell function. we performed a prospective observational clinical study in ICU in a trauma centre of the University hospital in Italy including twenty-three ICU patients with traumatic brain injury consecutively enrolled. Read More

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http://dx.doi.org/10.1038/s41598-019-42147-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465296PMC
April 2019
1 Read

Pre-hospital adenosine, lidocaine and magnesium has inferior survival compared to tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock.

J Trauma Acute Care Surg 2019 Apr 12. Epub 2019 Apr 12.

Naval Medical Research Unit San Antonio, JBSA-Ft. Sam Houston, TX.

Background: Adenosine, lidocaine, and magnesium (ALM) is a cardioplegic agent shown to improve survival by improving cardiac function, tissue perfusion, and coagulopathy in animal models of shock. We hypothesized pre-hospital ALM treatment in hemorrhagic shock would improve survival compared to current Tactical Combat Casualty Care (TCCC) resuscitation beyond the Golden Hour.

Methods: Swine were randomized to: 1) TCCC, 2) 2cc/kg vehicle control (VC), 3) 2cc/kg ALM+drip, 4) 4cc/kg ALM+drip, 5) 4cc/kg ALM+delayed drip at 0. Read More

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http://dx.doi.org/10.1097/TA.0000000000002308DOI Listing
April 2019
2 Reads

Electrical stimulation for neuroregeneration in urology: a new therapeutic paradigm.

Curr Opin Urol 2019 Apr 9. Epub 2019 Apr 9.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic.

Purpose Of Review: The present review highlights regenerative electrical stimulation (RES) as potential future treatment options for patients with nerve injuries leading to urological dysfunction, such as urinary incontinence, voiding dysfunction or erectile dysfunction. Additionally, it will highlight the mechanism of nerve injury and regeneration as well as similarities and differences between RES and current electrical stimulation treatments in urology, functional electrical stimulation (FES) and neuromodulation.

Recent Findings: It has been demonstrated that RES upregulates brain-derived neurotrophic factor (BDNF) and its receptor to facilitate neuroregeneration, facilitating accurate reinnervation of muscles by motoneurons. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000632DOI Listing
April 2019
2 Reads

Early intensive treatment to prevent kidney failure in post-traumatic rhabdomyolysis: Case report.

SAGE Open Med Case Rep 2019 3;7:2050313X19839529. Epub 2019 Apr 3.

Department of Intensive Care, "Pugliese-Ciaccio" General Hospital, Catanzaro, Italy.

Traumatic rhabdomyolysis is a clinical and biological syndrome secondary to lysis of striated muscle fibers resulting in extended musculoskeletal damage. An acute muscle damage causes the release of constituent elements of the sarcoplasmic reticulum, such as muscle enzymes, potassium, and myoglobin in plasma circulation; these conditions are at great risk of dangerous systemic complications for life such as hypovolemic shock, hyperkalemia, and acute kidney injury. We describe the case of a patient who suffered a severe musculoskeletal and vascular trauma with elevated creatine kinase values and myoglobinemia treated early with coupled plasma filtration adsorption in order to prevent kidney damage, associated with volume replacement, loop diuretics, and correction of metabolic acidosis. Read More

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http://dx.doi.org/10.1177/2050313X19839529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448103PMC
April 2019
1 Read

A novel cross-linked haemoglobin-based oxygen carrier is beneficial to sepsis in rats.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1496-1504

a State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital , Third Military Medical University (Army Medical University) , Chongqing , P.R. China.

Pathological hypoxia-induced organ dysfunction contributes to the high mortality of sepsis. Because of the microcirculation dysfunction following severe sepsis, it is difficult for erythrocytes to transport oxygen to hypoxic tissues. Haemoglobin-based oxygen carriers (HBOCs) are capable of delivering oxygen to hypoxic tissues. Read More

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http://dx.doi.org/10.1080/21691401.2019.1602049DOI Listing
December 2019
1 Read

Long-term renal outcomes in patients with traumatic renal injury after nephrectomy: A nationwide cohort study.

Int J Surg 2019 Apr 9;65:140-146. Epub 2019 Apr 9.

Division of Trauma and Emergency Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan, ROC.

Background: The long-term renal outcomes of patients who underwent nephrectomy for traumatic renal injury (TRI) have rarely been reported. Therefore, we investigated the impact of nephrectomy for TRI on long-term renal outcomes.

Methods And Materials: We extracted data from the National Health Insurance Research Database (NHIRD) of Taiwan from 1999 to 2013 and identified patients with TRI. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.04.001DOI Listing

Selective non-operative management for penetrating splenic trauma: a systematic review.

Eur J Trauma Emerg Surg 2019 Apr 10. Epub 2019 Apr 10.

Department of Trauma, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Introduction: The treatment of abdominal solid organ injuries has shifted towards non-operative management (NOM). However, the feasibility of NOM for penetrating splenic trauma is unclear and outcome is believed to be worse than NOM for penetrating liver and kidney injuries. Hence, the aim of the current systematic review was to evaluate the feasibility of selective NOM in penetrating splenic injury. Read More

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http://link.springer.com/10.1007/s00068-019-01117-1
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http://dx.doi.org/10.1007/s00068-019-01117-1DOI Listing
April 2019
2 Reads

The role of toll-like receptors in multifactorial mechanisms of early and late renal allotransplant injury, with a focus on the TLR4 receptor and mononuclear cells.

Adv Clin Exp Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Poland.

The innate immune system is activated before an adaptive immune response. An expression of a particular toll-like receptor (TLR) in a transplanted kidney depends on the localization of specific cells (e.g. Read More

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http://dx.doi.org/10.17219/acem/94139DOI Listing
April 2019
1 Read

Optical Metabolic Imaging for Assessment of Radiation-Induced Injury to Rat Kidney and Mitigation by Lisinopril.

Ann Biomed Eng 2019 Apr 8. Epub 2019 Apr 8.

Department of Electrical Engineering, Biophotonics Lab, University of Wisconsin Milwaukee, Milwaukee, WI, USA.

The kidney is one of the most radiosensitive organs; it is the primary dose-limiting organ in radiotherapies for upper abdominal cancers. The role of mitochondrial redox state in the development and treatment of renal radiation injury, however, remains ill-defined. This study utilizes 3D optical cryo-imaging to quantify renal mitochondrial bioenergetics dysfunction after 13 Gy leg-out partial body irradiation (PBI). Read More

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http://dx.doi.org/10.1007/s10439-019-02255-8DOI Listing

FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.

Oxid Med Cell Longev 2019 6;2019:3286928. Epub 2019 Mar 6.

Department of Endocrinology and Metabolism, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 Henan Province, China.

Objective: The generation of hyperglycemia-induced reactive oxygen species (ROS) is a key event in diabetic nephropathy (DN) development. Since forkhead box class O1 (FOXO1) is associated with oxidative stress and shows a positive effect on DN, its role on renal function and the underlying mechanism is still unclear.

Methods: We examined the role of FOXO1 (in a transgenic diabetic mouse model overexpressing ) and (in human HK-2 cells with knockin (KI) and knockout (KO) cultured under high glucose). Read More

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https://www.hindawi.com/journals/omcl/2019/3286928/
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http://dx.doi.org/10.1155/2019/3286928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431359PMC
March 2019
2 Reads

Radiation Mitigation Techniques in Kidney Stone Management.

Urol Clin North Am 2019 May 4;46(2):265-272. Epub 2019 Mar 4.

Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

Patients with nephrolithiasis are exposed to significant quantities of ionizing radiation with the potential to cause secondary malignancy. This risk is magnified by the high recurrence rate of nephrolithiasis. In this article, we identify the risks of ionizing radiation as they pertain to patients with nephrolithiasis. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.12.008DOI Listing
May 2019
2 Reads

Tips and Tricks for Performing a Retrograde Pyelogram.

Urology 2019 Apr 5. Epub 2019 Apr 5.

Department of Urology and Division of Urogynecology, University of New Mexico Health Science Center, Albuquerque, New Mexico.

Objective: To demonstrate indications, review tools and techniques, as well as abnormal findings when performing a retrograde pyelogram.

Methods: Retrograde pyelogram is a procedure which consists of introducing water-soluble contrast in a retrograde fashion into the ureter and collecting system of the kidney under fluoroscopic guidance. Conditions in which a retrograde pyelogram are indicated include iatrogenic ureteral injuries, ureteral obstruction, identification of stones or tumors, assistance for stent placement or ureteroscopy, and trauma evaluation. Read More

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http://dx.doi.org/10.1016/j.urology.2019.03.027DOI Listing

Effect of TIPE1 on immune function of dendritic cells and its signaling pathway in septic mice.

J Infect Dis 2019 Apr 8. Epub 2019 Apr 8.

Trauma Research Center, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People's Republic of China.

Dendritic cell (DC) dysfunction plays a pivotal role in sepsis-induced immunosuppression. TIPE1, a new member of the TNFAIP8 (tumor necrosis factor-α-induced protein 8) family, may be related to cell death. The aim of present study was to elucidate the effect of TIPE1 on immune function of DCs and its regulatory mechanism via PD-L1/PD-1 signaling in mice. Read More

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http://dx.doi.org/10.1093/infdis/jiz158DOI Listing
April 2019
1 Read
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Thoracoabdominal Approach for Large Retroperitoneal Masses: Case Series and Review.

Case Rep Urol 2019 10;2019:8071025. Epub 2019 Mar 10.

Section of Urology, University of Manitoba, Winnipeg, MB, Canada.

The thoracoabdominal incision was first described in 1946 as an approach to concomitant abdominal, retroperitoneal, and thoracic injuries. In urology, this technique was popularized in 1949 for the resection of large renal tumours. Today, it is reserved for complex cases where optimal exposure of the renal hilum and adrenal and superior pole of the kidney is necessary. Read More

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http://dx.doi.org/10.1155/2019/8071025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431445PMC
March 2019
1 Read

Rate and Outcome of Acute Kidney Injury Following Hip Fracture Surgery in Diabetic Older Patients Treated with Renin-Angiotensin-Aldosterone Antagonists.

Drugs Aging 2019 Apr 4. Epub 2019 Apr 4.

Department of Geriatrics, Rabin Medical Center, Beilinson Hospital, Petach Tikvah, Israel.

Background: The use of renin-angiotensin-aldosterone system inhibitors has increased over the past few years. There are conflicting data as to their relationship with acute kidney injury following surgery.

Objectives: The objective of the article was to evaluate the risk of acute kidney injury in diabetic older patients treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and their medical outcomes following fragility hip fracture surgery. Read More

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http://dx.doi.org/10.1007/s40266-019-00671-yDOI Listing
April 2019
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Penetrating Renal Trauma: Nonoperative Management Is Safe in Selected Patients.

Am Surg 2019 Mar;85(3):266-272

Present literature seems to support the nonoperative management of penetrating renal trauma although data remain limited. We conducted a nine-year retrospective review of nonoperative operative management and mechanism of injury [stab wound (SW) gunshot wound (GSW)] among patients admitted with penetrating renal trauma. Of 203 patients, the median age was 24 years, with the majority being male and having GSW injuries. Read More

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Validity of routine reimaging of blunt renal trauma managed conservatively.

Medicine (Baltimore) 2019 Apr;98(14):e15135

Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine, Warsaw, Poland.

The purpose of this study was to determine the need of repeat follow-up computed tomography imaging in patients with renal trauma.All patients who were admitted in the trauma center of the Military Institute of Medicine with a diagnosis of kidney injury from January 2008 to December 2017 were identified. A retrospective review of all patients' medical records and radiologic imaging was conducted. Read More

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http://dx.doi.org/10.1097/MD.0000000000015135DOI Listing
April 2019
3 Reads

Renoprotective effect of oral rehydration solution III in exertional heatstroke rats.

Ren Fail 2019 Nov;41(1):190-196

a Department of Nephrology , General Hospital of Northern Theater Command , Liaoning , China.

Aim: Exertional heastroke (EHS) can lead to acute kidney injury. Oral rehydration solution III (ORS III), recommended by WHO in 2004, is used to rehydrate children with gastroenteritis. This study aimed to characterize the renoprotective effect of ORS III in EHS rats. Read More

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https://www.tandfonline.com/doi/full/10.1080/0886022X.2019.1
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http://dx.doi.org/10.1080/0886022X.2019.1590211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450508PMC
November 2019
14 Reads

Subcutaneous Injection of Myrrh Essential Oil in Mice: Acute and Subacute Toxicity Study.

Evid Based Complement Alternat Med 2019 3;2019:8497980. Epub 2019 Mar 3.

Wonkwang University, College of Pharmacy, Department of Oriental Pharmacy & Wonkwang Oriental Medicines Research Institute, Iksan, Jeonbuk, Republic of Korea.

Myrrh essential oil (MEO) is widely used as remedies for the different human ailment in different parts of the world. The misuse of this natural product in higher doses may lead to fever, inflammation, and liver and kidney problems. In this study, we performed the acute and subacute toxicity analysis of MEO in mice model after subcutaneous injection and evaluated the safe dose to prevent the possible risk and side effects. Read More

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http://dx.doi.org/10.1155/2019/8497980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421018PMC
March 2019
3 Reads

Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-B-Mediated Inflammation.

Evid Based Complement Alternat Med 2019 3;2019:2190847. Epub 2019 Mar 3.

Hospital of Nephrology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, China.

Acute kidney injury (AKI) is a critical care syndrome, which is usually associated with sepsis-related endotoxemia. Evodiamine (EVO) is an active ingredient of many traditional medicinal formulations that possess a battery of biological activities. In the study, we aimed to evaluate the potential protective effect of EVO against lipopolysaccharide- (LPS-) induced AKI and cytotoxicity. Read More

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http://dx.doi.org/10.1155/2019/2190847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421037PMC
March 2019
2 Reads

Nephrogenic diabetes insipidus after esophagectomy in a patient with remote history of lithium treatment: A case report.

Int J Surg Case Rep 2019 Mar 19;57:71-73. Epub 2019 Mar 19.

Department of Internal Medicine, Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI, USA.

Introduction: Nephrogenic diabetes insipidus occurs in patients on chronic lithium treatment even after lithium discontinuation. Patients affected by this disorder are highly vulnerable to hypernatremia when they cannot respond to their thirst mechanism. We report a rare case of hypernatremia due to undiagnosed nephrogenic diabetes insipidus post esophagectomy in a patient with remote history of lithium use. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438906PMC
March 2019
1 Read

Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses.

Cell Death Discov 2019 18;5:78. Epub 2019 Mar 18.

1Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032 China.

Cyclic helix B peptide (CHBP) is a peptide derivant of erythropoietin with powerful tissue-protective efficacies in a variety of organ injuries, but without erythropoietic effect. However, the role of CHBP in acute myocardial infarction (AMI) and related mechanisms are not studied yet. In this study, we found in a murine AMI model that the administration of CHBP could ameliorate cardiac injury, increase the survival rate, inhibit cardiomyocyte apoptosis, improve cardiac function and remodeling, and reduce the expression of inflammatory cytokines in the serum and kidney tissue both at 24 h and 8 weeks following AMI. Read More

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http://dx.doi.org/10.1038/s41420-019-0161-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423043PMC
March 2019
1 Read

Traumatic renal injury in a UK major trauma centre - current management strategies and the role of early re-imaging.

BJU Int 2019 Mar 23. Epub 2019 Mar 23.

Department of Urology, St Mary's Hospital, Imperial College NHS Trust, London, UK.

Objectives: To analyse the contemporary management of renal injuries in a UK major trauma centre and to evaluate the utility and value of re-imaging.

Patients And Methods: The prospectively maintained 'Trauma Audit and Research Network' database was interrogated to identify patients with urinary tract injuries between January 2014 and December 2017. Patients' records and imaging were reviewed to identify injury grades, interventions, outcomes, and follow-up. Read More

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http://dx.doi.org/10.1111/bju.14752DOI Listing

Risk-Adjusted Comparison of In-Hospital Outcomes of Transcatheter and Surgical Aortic Valve Replacement.

J Am Heart Assoc 2019 Apr;8(7):e011504

1 University Heart Center Freiburg Department of Cardiology and Angiology I Faculty of Medicine University of Freiburg Freiburg Germany.

Background Transfemoral transcatheter aortic valve replacement (TF-TAVR) is recommended for patients suffering from aortic valve stenosis at increased operative risk. Beyond that, patients with different comorbidities could benefit from TF-TAVR. The present study compares real-world in-hospital outcomes of surgical aortic valve replacement and TF-TAVR. Read More

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http://dx.doi.org/10.1161/JAHA.118.011504DOI Listing
April 2019
2 Reads

[Retrospective study on the characteristics of early organ injury in elderly patients with severe burns].

Zhonghua Shao Shang Za Zhi 2019 Mar;35(3):163-168

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

To analyze the clinical characteristics of early organ injury in elderly patients with severe burns and the effects on the prognosis of patients. From January 2010 to August 2018, 62 patients with severe burns (43 men and 19 women, aged from 60 to 89 years at the time of admission) who were hospitalized in the Institute of Burn Research of the First Affiliated Hospital of Army Medical University (the Third Military Medical University, hereinafter referred to as the author's affiliation), meeting the inclusion criteria, were included in elderly (E) group, and 124 patients with severe burns (86 men and 38 women, aged from 18 to 59 years at the time of admission) at the same term were included in young and middle-aged (YM) group. Treatment of patients in the 2 groups followed the conventional procedures of the author's affiliation. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.03.002DOI Listing
March 2019
1 Read

Neuroimmune crosstalk in the pathophysiology of hypertension.

Nat Rev Cardiol 2019 Mar 20. Epub 2019 Mar 20.

Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy.

Hypertension is an important risk factor for cardiovascular morbidity and mortality and for events such as myocardial infarction, stroke, heart failure and chronic kidney disease and is a major determinant of disability-adjusted life-years. Despite the importance of hypertension, the pathogenesis of essential hypertension, which involves the complex interaction of several mechanisms, is still poorly understood. Evidence suggests that interplay between bone marrow, microglia and immune mediators underlies the development of arterial hypertension, in particular through mechanisms involving cytokines and peptides, such as neuropeptide Y, substance P, angiotensin II and angiotensin-(1-7). Read More

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http://dx.doi.org/10.1038/s41569-019-0178-1DOI Listing
March 2019
1 Read

Loss of the androgen receptor suppresses intrarenal calcium oxalate crystals deposition via altering macrophage recruitment/M2 polarization with change of the miR-185-5p/CSF-1 signals.

Cell Death Dis 2019 Mar 20;10(4):275. Epub 2019 Mar 20.

George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 14646, USA.

Crystals can trigger a wide range of kidney injuries that may link to the development of kidney stones. Infiltrating macrophages may influence hyperoxaluria-induced intrarenal calcium oxalate (CaOx) crystals deposition, yet their linkage to sex hormones remains unclear. Here we demonstrated that suppressing the androgen receptor (AR) expression in renal tubular epithelial cells increased the macrophage recruitment/M2 polarization that may result in enhancing the phagocytosis of intrarenal CaOx crystals. Read More

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http://dx.doi.org/10.1038/s41419-019-1358-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427030PMC
March 2019
1 Read

Vitamin D-Binding Protein Deficiency and Homozygous Deletion of the Gene.

N Engl J Med 2019 03;380(12):1150-1157

From the Departments of Laboratory Medicine (C.M.H., S.L.F., T.J.L., K.J.J., A.N.H.) and Medicine (A.N.H.) and the Kidney Research Institute (A.N.H.), University of Washington, Seattle; and the Department of Endocrinology and Metabolism (H.B.) and the Alberta Children's Hospital Research Institute (B.A.), University of Calgary, and the Division of Medical Genetics, Alberta Children's Hospital (R.L., P.F., J.L.M.), Calgary, and the Department of Pathology, Children's & Women's Health Centre of British Columbia, Vancouver (L.B.) - all in Canada.

A 58-year-old woman with debilitating ankylosing spondylitis who was born to consanguineous parents was found to have an apparent severe vitamin D deficiency that did not respond to supplementation. Liquid chromatography-tandem mass spectrometry showed the absence of circulating vitamin D-binding protein, and chromosomal microarray confirmed a homozygous deletion of the group-specific component () gene that encodes the protein. Congenital absence of vitamin D-binding protein resulted in normocalcemia and a relatively mild disruption of bone metabolism, in this case complicated by severe autoimmune disease. Read More

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http://dx.doi.org/10.1056/NEJMoa1807841DOI Listing
March 2019
2 Reads

Nationwide Analysis of Resuscitative Endovascular Balloon Occlusion of the Aorta in Civilian Trauma.

JAMA Surg 2019 Mar 20. Epub 2019 Mar 20.

Division of Acute Care Surgery, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia.

Importance: The need for improved methods of hemorrhage control and resuscitation has resulted in a reappraisal of resuscitative endovascular balloon occlusion of the aorta (REBOA). However, there is a paucity of data regarding the use of REBOA on a multi-institutional level in the United States.

Objective: To evaluate the outcomes in trauma patients after REBOA placement. Read More

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http://dx.doi.org/10.1001/jamasurg.2019.0096DOI Listing
March 2019
3 Reads

4-Factor Prothrombin Complex Concentrate is associated with Improved Survival in Trauma Related Hemorrhage: A Nationwide Propensity Matched Analysis.

J Trauma Acute Care Surg 2019 Mar 15. Epub 2019 Mar 15.

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona.

Introduction: Post-traumatic hemorrhage is the most common preventable cause of death in trauma. Numerous small single-center studies have shown the superiority of 4-factor prothrombin complex concentrate(4-PCC) along with fresh frozen plasma (FFP) over FFP-alone in resuscitation of trauma patients. The aim of our study was to evaluate outcomes of severely injured trauma patients who received 4-PCC+FFP compared to FPP-alone. Read More

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http://dx.doi.org/10.1097/TA.0000000000002262DOI Listing
March 2019
4 Reads

Use of a subcutaneous ureteral bypass device for treatment of bilateral proximal ureteral injury in a 9-month-old cat.

JFMS Open Rep 2019 Jan-Jun;5(1):2055116919831856. Epub 2019 Mar 11.

The Animal Referral Hospital Homebush, NSW, Australia.

Case Summary: A 9-month-old male domestic longhair cat presented following iatrogenic ureteral trauma after an attempted laparoscopic ovariectomy. Prior to identifying that the cat was male, both ureters were transected approximately 4 mm from the renal pelves. Initial management involved a left-sided Boari flap neoureterocystostomy, cystonephropexy and right ureteronephrectomy. Read More

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http://dx.doi.org/10.1177/2055116919831856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415474PMC
March 2019
7 Reads

Oxidative Stress in Animal Models of Acute and Chronic Renal Failure.

Dis Markers 2019 11;2019:8690805. Epub 2019 Feb 11.

Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

Introduction: Kidney disease is a worldwide health and economic burden, with rising prevalence. The search for biomarkers for earlier and more effective disease screening and monitoring is needed. Oxidative stress has been linked to both, acute kidney injury (AKI) and chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1155/2019/8690805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388331PMC
February 2019
1 Read

Higher Body Mass Index and Black Race Increase Risk of Rhabdomyolysis and Acute Kidney Injury After Trauma.

J Invest Surg 2019 Mar 19:1-2. Epub 2019 Mar 19.

a Department of Surgery , Morristown Medical Center , Morristown , NJ , USA.

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http://dx.doi.org/10.1080/08941939.2018.1502378DOI Listing
March 2019
1 Read

Inhibition of Cerebral High-Mobility Group Box 1 Protein Attenuates Multiple Organ Damage and Improves T Cell-Mediated Immunity in Septic Rats.

Mediators Inflamm 2019 10;2019:6197084. Epub 2019 Feb 10.

School of Medicine, Nankai University, Tianjin 300071, China.

Sepsis remains one of the leading causes of mortality in intensive care units, but there is a shortage of effective treatments. A dysregulated host immune response and multiple organ injury are major factors for the pathogenesis and progression of sepsis, which require specific mechanism and treatment. In the present study, we performed an intracerebroventricular (ICV) injection of BoxA, a specific antagonist of high-mobility group box 1 protein (HMGB1), in septic rats that were produced by cecal ligation and puncture surgery; we further assessed the functional changes of multiple organs and splenic T lymphocytes. Read More

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http://dx.doi.org/10.1155/2019/6197084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387733PMC
February 2019

External Iliac Artery Dissection During Renal Transplantation: A Case Report and Literature Review.

Transplant Proc 2019 Mar 3;51(2):538-540. Epub 2019 Jan 3.

Department of Surgery, Division of Renal and Pancreas Transplant, Saint Barnabas Medical Center, Livingston, New Jersey, USA.

Iliac artery dissection in the setting of renal transplant is a rare but potentially catastrophic event that may result in loss of kidney and lower extremity perfusion. We report a right external iliac artery dissection in a 45-year-old man with end-stage renal disease, diabetes, and hypertension who underwent a renal transplant at our institution. An external iliac artery dissection was diagnosed intraoperatively after completion of the arterial anastomosis given the mottled appearance of the kidney and loss of Doppler signal. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.021DOI Listing
March 2019
2 Reads

A Prospective Study Analyzing the Association Between High-grade Ureteral Access Sheath Injuries and the Formation of Ureteral Strictures.

Urology 2019 Mar 14. Epub 2019 Mar 14.

Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH.

Objective: To assess the intermediate- and long-term effect of high-grade ureteral injuries from ureteral access sheaths.

Methods: Patients undergoing ureteroscopy for upper tract calculi were prospectively enrolled at 2 sites from 2010 to 2015. A 12/14 French sheath was used and the ureter was inspected with a flexible ureteroscope during withdrawal of the sheath and recorded. Read More

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http://dx.doi.org/10.1016/j.urology.2019.02.032DOI Listing
March 2019
6 Reads

Pathophysiology and Treatment of Hepatitis B and C Infections in Patients With End-Stage Renal Disease.

Adv Chronic Kidney Dis 2019 Jan;26(1):41-50

Division of Nephrology & Hypertension, Henry Ford Health System, Detroit, MI.

An in-depth understanding of viral hepatitis is important to the care of patients with end-stage renal disease undergoing hemodialysis. Both hepatitis B and C viruses are acquired through hematogenous spread and can lead to horizontal transmission. Concurrent hepatic and renal injuries have ominous outcomes with significant morbidity. Read More

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http://dx.doi.org/10.1053/j.ackd.2018.10.004DOI Listing
January 2019

An Increasing Neutrophil-to-Lymphocyte Ratio Trajectory Predicts Organ Failure in Critically-Ill Male Trauma Patients. An Exploratory Study.

Healthcare (Basel) 2019 Mar 14;7(1). Epub 2019 Mar 14.

Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35249, USA.

Although the association of neutrophil proportions with mortality in trauma patients has recently been shown, there is a paucity of research on the association with other outcomes. We sought to investigate the association of neutrophil proportions with organ failure in critically-ill trauma patients. We reviewed a randomly-selected group of trauma patients admitted to our level-1 trauma intensive care unit between July 2007 and December 2016. Read More

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http://dx.doi.org/10.3390/healthcare7010042DOI Listing
March 2019
1 Read

Characteristics and relative numbers of lethal snake bite cases in medicolegal practice in central Myanmar - A five year study.

J Forensic Leg Med 2019 Apr 5;63:52-55. Epub 2019 Mar 5.

The University of Adelaide Medical School, Frome Road, Adelaide, SA, 5005, Australia; Forensic Science SA, 21 Divett Place, Adelaide, SA, 5000, Australia. Electronic address:

Clinical and pathological case files of lethal snakebites were reviewed from the XXXX, Magway, Myanmar, over a five-year period (January 2013 December 2017). A total of 2069 postmortem examinations were performed which included 84 cases of lethal snake bite (4.1%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1752928X183050
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http://dx.doi.org/10.1016/j.jflm.2019.03.005DOI Listing
April 2019
3 Reads

Metabolitic profiling of amino acids in paraquat-induced acute kidney injury.

Clin Exp Nephrol 2019 Apr 11;23(4):474-483. Epub 2019 Mar 11.

Department of Nephrology and Rheumatology, Affiliated Shanghai Tenth Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Background: The herbicide paraquat (1, 1'-dimethyl-4, 4'-bipyridylium dichloride; PQ) is a poison well-known to cause delayed mortality due to acute kidney injuries (AKI). This study examines the changes in serum amino acids (AAs) metabolite profiles as surrogate markers of renal cell metabolism and function after paraquat poisoning.

Methods: To identify the metabolic profiling of free serum AAs and its metabolites, serum from 40 paraquat-poisoned patients with or without AKI is collected. Read More

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http://dx.doi.org/10.1007/s10157-019-01702-zDOI Listing

Phytochemical Screening and Toxicological Study of Linn Roots: Histopathological and Biochemical Evidence.

J Toxicol 2019 3;2019:8203832. Epub 2019 Feb 3.

Laboratory of Chemistry-Biochemistry, Environment, Nutrition, and Health, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, 19 rue Tarik Ibn Ziad, Casablanca, Morocco.

(A) is a wild species of Aristolochiaceae family; its roots are used by Moroccan people against cancer for many years ago. The objective of the study was to investigate the phytochemical screening, acute and subacute toxicity of roots growing in the north of Morocco. Qualitative and quantitative analyses of roots were performed using standard methods; the acute toxicity of the root extract of the studied plant was assessed in mice by gavage of single doses of 1, 2, and 4 g/kg body weight for 14 days; by the time the subacute toxicity was done using repeated doses 1, 1. Read More

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http://dx.doi.org/10.1155/2019/8203832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377958PMC
February 2019
1 Read

Relationship Between Statin Use and Outcomes in Patients Having Cardiac Arrest (from a Nationwide Cohort Study in Taiwan).

Am J Cardiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Emergency Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine (Cardiology), College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Pretreatment with statins is associated with improved outcomes in severe sepsis, acute coronary syndrome, and stroke. Patients with cardiac arrest experience sepsis-like syndrome and ischemia reperfusion injuries in the heart and brain. The objective of this study was to investigate the effects of statin use before cardiac arrest on outcomes in cardiac arrest patients. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.018DOI Listing
February 2019
2 Reads

Value of aggressive surgical and intensive care unit in elderly patients with traumatic spinal cord injury.

Neurosurg Focus 2019 Mar;46(3):E3

Departments of1Neurological Surgery.

OBJECTIVEThe elderly are a growing subpopulation within traumatic spinal cord injury (SCI) patients. Studies have reported high morbidity and mortality rates in elderly patients who undergo surgery for SCI. In this study, the authors compare the perioperative outcomes of surgically managed elderly SCI patients with those of a younger cohort and those reported in the literature. Read More

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http://dx.doi.org/10.3171/2018.12.FOCUS18555DOI Listing
March 2019
3 Reads

Tangeretin protects renal tubular epithelial cells against experimental cisplatin toxicity.

Iran J Basic Med Sci 2019 Feb;22(2):179-186

Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.

Materials And Methods: Tangeretin was injected intraperitoneally at 2. Read More

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http://dx.doi.org/10.22038/ijbms.2018.32010.7691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396985PMC
February 2019
2 Reads
0.604 Impact Factor

Nonoperative management of solid abdominal organ injuries: From past to present.

Authors:
A Leppäniemi

Scand J Surg 2019 Mar 4:1457496919833220. Epub 2019 Mar 4.

Abdominal Center, Meilahti Hospital, University of Helsinki, Helsinki, Finland.

Background And Aims:: Today, a significant proportion of solid abdominal organ injuries, whether caused by penetrating or blunt trauma, are managed nonoperatively. However, the controversy over operative versus nonoperative management started more than a hundred years ago. The aim of this review is to highlight some of the key past observations and summarize the current knowledge and guidelines in the management of solid abdominal organ injuries. Read More

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http://dx.doi.org/10.1177/1457496919833220DOI Listing
March 2019
2 Reads

A new enzymatic method for extracting diatoms from organs of suspected drowning cases using papain: Optimal digestion and first practical application.

Forensic Sci Int 2019 Apr 13;297:204-216. Epub 2019 Feb 13.

Division of Legal Medicine, Department of Social Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake-cho, Miyazaki, 889-1692, Japan. Electronic address:

Diatom analysis is very effective for positive diagnosis of water inhalation in drowning. However, conventional strong acid diatom testing is laborious and potentially dangerous. We propose a simple, fast, and safe protocol using inexpensive reagents such as papain, SDS, and 5 N HCl for extracting diatoms from lung, kidney, and liver tissues. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.02.008DOI Listing
April 2019
2 Reads

Renal pseudoaneuryms and pulmonary embolism: A unique manifestation of complications following blunt renal trauma.

Urol Case Rep 2019 May 24;24:100835. Epub 2019 Jan 24.

Department of Urology, Cantonal Hospital Aarau, Aarau, 5001, Switzerland.

This case report presents a unique manifestation of complications in a 71-year-old man following blunt renal trauma. Initially, computed tomography (CT) revealed a traumatic left kidney laceration. Hematuria ceased quickly after ureteral stent placement. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383189PMC
May 2019
1 Read

Risk factors and outcome of acute kidney injury in elderly trauma patients.

Am J Surg 2019 Feb 12. Epub 2019 Feb 12.

Department of Surgery, University of Louisville, Louisville, KY, 40202, USA.

Background: Acute Kidney Injury (AKI) is associated with significant morbidity. The risk factors for AKI in elderly trauma patients have not been defined.

Methods: Injured patients 75 years old or older from 2014 to 2016 were evaluated. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.02.007DOI Listing
February 2019
5 Reads