24,259 results match your criteria Kidney Trauma


Kidney Organoids: A pioneering model for kidney diseases.

Transl Res 2022 Jun 21. Epub 2022 Jun 21.

Nephrology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute (HSCI), Cambridge, MA, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. Electronic address:

The kidney is a vital organ that regulates the bodily fluid and electrolyte homeostasis via tailored urinary excretion. Kidney injuries that cause severe or progressive chronic kidney disease have driven the growing population of patients with end-stage kidney disease, leading to substantial patient morbidity and mortality. This irreversible kidney damage has also created a huge socioeconomical burden on the healthcare system, highlighting the need for novel translational research models for progressive kidney diseases. Read More

View Article and Full-Text PDF

Liquiritigenin protects against myocardial ischemic by inhibiting oxidative stress, apoptosis, and L-type Ca channels.

Phytother Res 2022 Jun 23. Epub 2022 Jun 23.

College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China.

Liquiritigenin (Lq) offers cytoprotective effects against various cardiac injuries, but its beneficial effects on myocardial ischemic (MI) injury and the related mechanisms remain unclear. In the in vivo study, an animal model of MI was induced by intraperitoneal injection of isoproterenol (Iso, 85 mg/kg). ECG, heart rate, serum levels of CK and CK-MB, histopathological changes, and reactive oxygen species (ROS) levels were all measured. Read More

View Article and Full-Text PDF

Systemic injury caused by taurocholate-induced severe acute pancreatitis in rats.

Exp Ther Med 2022 Jul 26;24(1):468. Epub 2022 May 26.

Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.

Systemic injury plays a central role in severe acute pancreatitis (SAP). Retrograde biliopancreatic duct infusion of sodium taurocholate (NaT) is commonly used to establish SAP animal models. To better characterize the systemic injury in this model, SAP was induced in Sprague-Dawley rats by NaT administration (3. Read More

View Article and Full-Text PDF

Renal Protective Effects of Melatonin in Animal Models of Diabetes Mellitus-Related Kidney Damage: A Systematic Review and Meta-Analysis.

J Diabetes Res 2022 14;2022:3770417. Epub 2022 Jun 14.

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100700, China.

Diabetic nephropathy (DN)-chronic kidney damage caused by hyperglycemia-eventually develops into end-stage renal disease (ESRD). Melatonin is a powerful antioxidant that has a wide range of biological activities. Potentially helpful effects of melatonin on diabetic kidney disease have been found in several studies. Read More

View Article and Full-Text PDF

CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators.

Molecules 2022 Jun 16;27(12). Epub 2022 Jun 16.

Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiological Disorders, Wuhan 430030, China.

Inflammation plays a crucial role in the initiation and development of a wide range of systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) metabolized by CYP450 epoxygenase (CYP450) and are subsequently hydrolyzed by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs), which are merely biologically active. EETs possess a wide range of established protective effects on many systems of which anti-inflammatory actions have gained great interest. Read More

View Article and Full-Text PDF

Evaluation of the Effect of Wheat Germ Oil and Olmutinib on the Thioacetamide-Induced Liver and Kidney Toxicity in Mice.

Life (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Department of Anatomy, College of Medicine, King Khalid University Hospital, Riyadh 11451, Saudi Arabia.

Thioacetamide (TAA) intoxication produces a reproducible standard animal model of induced liver and kidney injuries where free radicals are produced by phase I oxidation reactions, which eventually leads to liver and kidney failure. Wheat germ oil (WGO) is a unique food supplement with concentrated nutrient efficiency and has remarkable antioxidant functions. Olmutinib, on the other hand, is a chemotherapy drug considered safe for kidneys and the liver. Read More

View Article and Full-Text PDF

Effect of L. on the Efficacy and Toxicity of Doxorubicin in Mice Bearing Ehrlich Ascites Carcinoma.

Antioxidants (Basel) 2022 May 31;11(6). Epub 2022 May 31.

Indian Council of Medical Research, National Institute of Traditional Medicine, Belagavi 590010, Karnataka, India.

Background And Objective: Doxorubicin is a widely used chemotherapeutic agent that causes oxidative stress leading to cardiotoxicity, hepatotoxicity, and nephrotoxicity. In contrast, L. has been recorded as an anticancer agent and found to be protective against multiple chemical-induced organ injuries, including heart, liver, and kidney injuries. Read More

View Article and Full-Text PDF

Outcome of post-traumatic acute respiratory distress syndrome in young patients requiring extracorporeal membrane oxygenation (ECMO).

Sci Rep 2022 Jun 23;12(1):10609. Epub 2022 Jun 23.

Department of Internal Medicine, Hamad General Hospital, Doha, Qatar.

We aimed to evaluate the outcomes of post-traumatic acute respiratory distress syndrome (ARDS) in young patients with and without Extracorporeal membrane oxygenation (ECMO) support. A retrospective analysis was conducted for trauma patients who developed ARDS at a level I trauma facility between 2014 and 2020. Data were analyzed and compared between ECMO and non-ECMO group. Read More

View Article and Full-Text PDF

Role of Contrast Enhanced Ultrasound (CEUS) in the Paediatric Population with Blunt Abdominal Trauma: A Prospective Study from a Single Center Experience for Paediatric Blunt Abdominal Trauma.

Maedica (Bucur) 2022 Mar;17(1):44-51

Department of Pediatric Surgery, Democritus University of Thrace, University Hospital of Alexandroupolis, Dragana, Alexandroupolis, 68100, Greece, ORCID ID: 0000-0003-0817-6513.

The aim of our study is to evaluate the diagnostic ability of contrast-enhanced ultrasonography (CEUS) in pediatric population with history of blunt abdominal trauma (BAT). In an eight-year period (1/2012-1/2020), fifty-nine children (4-14 years old) were transferred to the Emergency Department with referred BAT. The initial imaging method was ultrasound scan (US). Read More

View Article and Full-Text PDF

SERS based Y-shaped aptasensor for early diagnosis of acute kidney injury.

RSC Adv 2022 May 26;12(25):15910-15917. Epub 2022 May 26.

Laboratory of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University Haikou 571199 China

Considering the pivotal role of biomarkers in plasma, the development of biomarker specific sensing platforms is of great significance to achieve accurate diagnosis and monitor the occurrence and progress in acute kidney injury (AKI). In this paper, we develop a promising surface-enhanced Raman scattering-based aptasensor for duplex detection of two protein biomarkers in AKI. Exploiting the base-pairing specificity of nucleic acids to form a Y-shaped self-assembled aptasensor, the MGITC labelled gold nanoparticles will be attached to the surface of magnetic beads. Read More

View Article and Full-Text PDF

Melioidosis: an unusual diagnosis for deep temporal and masticatory space infection following trauma.

BMJ Case Rep 2022 Jun 22;15(6). Epub 2022 Jun 22.

Oral & Maxillofacial Surgery, AB Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India.

We report a patient in his early 70s, with an alleged history of trauma to the right temporal region, following which a swelling developed. A week later, erythematous changes, throbbing pain and occasional fever spikes were noted. A month after the initial trauma, he presented to our institution with necrosed skin over the right temporal region and swelling extending up to the vertex of the skull. Read More

View Article and Full-Text PDF

Intraoperative complications in kidney tumor surgery: critical grading for the European Association of Urology intraoperative adverse incident classification.

Scand J Urol 2022 Jun 22:1-8. Epub 2022 Jun 22.

Deparment of Urology, Tampere University Hospital and University of Tampere, Tampere, Finland.

Introduction: The European Association of Urology committee in 2020 suggested a new classification, intraoperative adverse incident classification (EAUiaiC), to grade intraoperative adverse events (IAE) in urology.

Aims: We applied and validated EAUiaiC, for kidney tumor surgery.

Patients And Methods: A retrospective multicenter study was conducted based on chart review. Read More

View Article and Full-Text PDF

Blocking cell cycle progression through CDK4/6 protects against chronic kidney disease.

JCI Insight 2022 Jun 22;7(12). Epub 2022 Jun 22.

Division of Nephrology and Hypertension, Department of Medicine, Washington University St. Louis, St. Louis, Missouri, USA.

Acute and chronic kidney injuries induce increased cell cycle progression in renal tubules. While increased cell cycle progression promotes repair after acute injury, the role of ongoing tubular cell cycle progression in chronic kidney disease is unknown. Two weeks after initiation of chronic kidney disease, we blocked cell cycle progression at G1/S phase by using an FDA-approved, selective inhibitor of CDK4/6. Read More

View Article and Full-Text PDF

Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6.

Phytomedicine 2022 Jun 13;104:154276. Epub 2022 Jun 13.

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Background: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. DN is the main cause of end-stage renal disease (ESRD). SIRT6 becomes the important target of DN. Read More

View Article and Full-Text PDF

Comparison of Application of MD-VF-Auto SEM Method and Plankton Gene Multiplex PCR System in the Diagnosis of Drowning.

Fa Yi Xue Za Zhi 2022 Feb;38(1):114-118

Huadu District Branch of Guangzhou Public Security Bureau, Guangzhou 510800, China.

Objectives: To compare the application effect of microwave digestion - vacuum filtration - automated scanning electron microscopy (MD-VF-Auto SEM) method and plankton gene multiplex PCR system in the diagnosis of drowning.

Methods: Lung, liver and kidney tissue of 10 non-drowning cases and 50 drowning cases were prepared for further MD-VF-Auto SEM method analysis and plankton gene multiplex PCR system analysis. The positive detection rate of the two methods in each tissue was calculated. Read More

View Article and Full-Text PDF
February 2022

Application of Diatoms Quantitative Analysis in the Diagnosis of Drowning.

Fa Yi Xue Za Zhi 2022 Feb;38(1):110-113

Guangzhou Forensic Science Institute & Key Laboratory of Forensic Pathology, Ministry of Public Security, Guangzhou 510442, China.

Objectives: To retrospectively analyze diatom test cases of corpses in water and discuss the value of quantitative analysis of diatoms in the diagnosis of drowning.

Methods: A total of 490 cases of water-related death were collected. They were divided into drowning group and postmortem immersion group according to the cause of death. Read More

View Article and Full-Text PDF
February 2022

Pathway of Diatoms Enter Experimental Rabbits through the Lymphatic System of the Digestive Tract.

Fa Yi Xue Za Zhi 2022 Feb;38(1):67-70

Guangzhou Forensic Science Institute & Key Laboratory of Forensic Pathology, Ministry of Public Security, Guangzhou 510442, China.

Objectives: To study whether diatoms can enter the body through the lymphatic system of the digestive tract.

Methods: Twenty experimental rabbits were divided into the test group and the control group randomly, and intragastric administration was performed with 20 mL water sample from the Pearl River and 20 mL ultrapure water, respectively. After 30 min, lymph, lungs, livers and kidneys were extracted for the diatom test. Read More

View Article and Full-Text PDF
February 2022

Construction and Application of YOLOv3-Based Diatom Identification Model of Scanning Electron Microscope Images.

Fa Yi Xue Za Zhi 2022 Feb;38(1):46-52

Department of Forensic Medicine, Nanjing Medical University, Nanjing 211126, China.

Objectives: To construct a YOLOv3-based model for diatom identification in scanning electron microscope images, explore the application performance in practical cases and discuss the advantages of this model.

Methods: A total of 25 000 scanning electron microscopy images were collected at 1 500× as an initial image set, and input into the YOLOv3 network to train the identification model after experts' annotation and image processing. Diatom scanning electron microscopy images of lung, liver and kidney tissues taken from 8 drowning cases were identified by this model under the threshold of 0. Read More

View Article and Full-Text PDF
February 2022

Evaluation of Inspection Efficiency of Diatom Artificial Intelligence Search System Based on Scanning Electron Microscope.

Fa Yi Xue Za Zhi 2022 Feb;38(1):40-45

Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

Objectives: To explore the application values of diatom artificial intelligence (AI) search system in the diagnosis of drowning.

Methods: The liver and kidney tissues of 12 drowned corpses were taken and were performed with the diatom test, the view images were obtained by scanning electron microscopy (SEM). Diatom detection and forensic expert manual identification were carried out under the thresholds of 0. Read More

View Article and Full-Text PDF
February 2022

Penetrating renal injuries: an observational study of non-operative management and the impact of opening Gerota's fascia.

World J Emerg Surg 2022 Jun 20;17(1):35. Epub 2022 Jun 20.

Groote Schuur Hospital, University of Cape Town, Main Road, Observatory, Cape Town, 7925, South Africa.

Background: Non-operative management has become increasingly popular in the treatment of renal trauma. While data are robust in blunt mechanisms, the role of non-operative management in penetrating trauma is less clear. Additionally, there is a paucity of data comparing gunshot and stab wounds. Read More

View Article and Full-Text PDF

Sickle cell trait and multisystem trauma: an unaddressed urgent knowledge gap.

Trauma Surg Acute Care Open 2022 5;7(1):e000955. Epub 2022 Jun 5.

Department of Surgery, Biological Sciences Division, University of Chicago, Chicago, Illinois, USA.

Sickle cell trait (SCT) has historically been considered a benign condition, but SCT-positive patients have increased baseline risk of venous thromboembolism and chronic kidney disease, as well as increased risk of sickled erythrocytes in settings of hypoxia, acidosis, and hypovolemia. Multisystem traumatic injuries are a common clinical scenario, in which hypoxia, acidosis, and hypovolemia occur; however, little is known about how SCT-positive status impacts outcomes in multisystem trauma. We conducted a scoping literature review to investigate what was known about SCT in the setting of multisystem trauma. Read More

View Article and Full-Text PDF

Whole transcriptome sequencing analysis revealed key RNA profiles and toxicity in mice after chronic exposure to microplastics.

Chemosphere 2022 Oct 16;304:135321. Epub 2022 Jun 16.

Division of Cardiology, Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 200336, China. Electronic address:

Investigating the long-term effects of microplastics (MPs) in vivo is necessary for evaluating its biological toxicity. Previously, we showed that MPs elicit vascular dysfunctions in atherosclerotic mice. However, the effects of long-term treatment with environmental levels of MPs on biological functions and RNA expression profiles in wild-type mice are unknown. Read More

View Article and Full-Text PDF
October 2022

Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3.

Phytomedicine 2022 Aug 8;103:154256. Epub 2022 Jun 8.

Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application of the Ministry of Agriculture and Rural Affairs and State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.

Background: Hyperuricemia is characterized with high serum uric acids (SUAs) and directly causes suffering gout. Caffeic acid phenethyl ester (CAPE) is widely included in dietary plants and especially propolis of honey hives.

Hypothesis/purpose: Since CAPE exerts a property resembling a redox shuttle, the hypothesis is that it may suppress xanthine oxidase (XOD) and alleviate hyperuricemia. Read More

View Article and Full-Text PDF

Using Two Predictor Scoring Systems Together to Increase the Chance of Identifying the Augmented Renal Clearance Phenomenon: A Cross-sectional Study.

Iran J Kidney Dis 2022 May;16(3):179-187

Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Augmented Renal Clearance (ARC) reflects a measured creatinine clearance (CrCl) of more than 130 ml/min. Also, there are two scoring systems for the prediction of the ARC phenomenon i.e. Read More

View Article and Full-Text PDF

The Scientific Rationale for the Introduction of Renalase in the Concept of Cardiac Fibrosis.

Front Cardiovasc Med 2022 31;9:845878. Epub 2022 May 31.

Institute of Pathophysiology, Faculty of Medicine, University of Niš, Niš, Serbia.

Cardiac fibrosis represents a redundant accumulation of extracellular matrix proteins, resulting from a cascade of pathophysiological events involved in an ineffective healing response, that eventually leads to heart failure. The pathophysiology of cardiac fibrosis involves various cellular effectors (neutrophils, macrophages, cardiomyocytes, fibroblasts), up-regulation of profibrotic mediators (cytokines, chemokines, and growth factors), and processes where epithelial and endothelial cells undergo mesenchymal transition. Activated fibroblasts and myofibroblasts are the central cellular effectors in cardiac fibrosis, serving as the main source of matrix proteins. Read More

View Article and Full-Text PDF

Does the anatomical region predict blood loss or neurological deficits in embolized renal cancer spine metastases? A single-center experience with 31 patients.

World J Surg Oncol 2022 Jun 16;20(1):208. Epub 2022 Jun 16.

Department of Orthopedics, Trauma and Plastic Surgery, University Hospital Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.

Background: No comparison of a single hypervascular tumor entity in terms of major complications in different spinal regions has been performed. We aimed to evaluate post-embolic and post-operative outcomes in anatomic regions with renal cell carcinoma (RCC) metastases to the spine.

Methods: We retrospectively evaluated data from patients with confirmed, embolized, and surgically treated RCC spine metastases at a single-spine center between 2010 and 2020. Read More

View Article and Full-Text PDF

PPARα alleviates iron overload-induced ferroptosis in mouse liver.

EMBO Rep 2022 Jun 15:e52280. Epub 2022 Jun 15.

College of Veterinary Medicine/College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, China.

Ferroptosis is an iron-dependent form of non-apoptotic cell death implicated in liver, brain, kidney, and heart pathology. How ferroptosis is regulated remains poorly understood. Here, we show that PPARα suppresses ferroptosis by promoting the expression of glutathione peroxidase 4 (Gpx4) and by inhibiting the expression of the plasma iron carrier TRF. Read More

View Article and Full-Text PDF

Antidiabetic and hepato-renal protective effects of medicinal plants in STZ induced diabetic rats.

Braz J Biol 2022 10;84:e260189. Epub 2022 Jun 10.

University of Malakand, Department of Zoology, Dir Lower, Khyber Pakhtunkhwa, Pakistan.

The antidiabetic and hepato-renal protective effects of Citrullus colocynthis and Momordica charantia ethanol extracts were investigated in streptozotocin (STZ) induced diabetic male albino rats. Diabetic rats were treated with C. colocynthis, M. Read More

View Article and Full-Text PDF

RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-κB signaling pathways.

Int Immunopharmacol 2022 Aug 11;109:108904. Epub 2022 Jun 11.

Department of Nephrology, The First Clinical Medical College of Three Gorges University, Center People's Hospital of Yichang, Yichang, Hubei 443000, China. Electronic address:

Acute kidney injury (AKI) is a critical and severe clinical disease caused by a variety of factors. Toll-like receptors (TLRs) play a crucial role in pathogenesis of AKI. Radioprotective 105 kDa protein (RP105) is a member of the TLR family, but the role of RP105 in AKI is unknown. Read More

View Article and Full-Text PDF

Ischemic Postconditioning Attenuates Bilateral Renal Ischemia-induced Cognitive Impairments.

Basic Clin Neurosci 2021 Nov-Dec;12(6):789-804. Epub 2021 Nov 1.

Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: Acute Kidney Injury (AKI) is a frequent complication of kidney failure with high mortality, leading to brain dysfunction. This study aimed to investigate the possible protective effect of Ischemic Postconditioning (IPo) against brain dysfunction induced by Bilateral Renal Ischemia (BRI).

Methods: Male Wistar rats underwent BRI, sham, or IPo surgery 24h and 1w after reperfusion. Read More

View Article and Full-Text PDF
November 2021