20,374 results match your criteria Kidney Trauma


Therapeutic Opportunities for Hepcidin in Acute Care Medicine.

Crit Care Clin 2019 Apr 30;35(2):357-374. Epub 2019 Jan 30.

La Jolla Pharmaceutical Company, 4550 Towne Centre Court, San Diego, CA 92121, USA; Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

Iron homeostasis is often disrupted in acute disease with an increase in catalytic free iron leading to the formation of reactive oxygen species and subsequent tissue-specific oxidative damage. This article highlights the potential therapeutic benefit of exogenous hepcidin to prevent and treat iron-induced injury, specifically in the management of infection from enteric gram-negative bacilli or fungi, malaria, sepsis, acute kidney injury, trauma, transfusion, cardiopulmonary bypass surgery, and liver disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccc.2018.11.014DOI Listing

Propolis and Its Combination with Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats.

Biol Trace Elem Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, Faculty of Science, Dokuz Eylül University, Izmir, Turkey.

Ischemia reperfusion (I/R) injury which causes kidney dysfunction is one of the most studied diseases directly linked to oxidative stress. In this regard, it is important to protect cells against damage by inducing antioxidant response. Herein, we aimed to evaluate the therapeutic roles and possible mechanisms of propolis and boric acid in kidney I/R injury based on relevant basic research and clinical studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12011-019-1649-2DOI Listing
February 2019

Response to "Are fluids resuscitation the "Keyser Soze" of acute kidney injury in trauma patients?"

Crit Care 2019 Feb 19;23(1):59. Epub 2019 Feb 19.

Department of Anesthesiology and Critical Care, Bicêtre Hôpitaux Universitaires Paris Sud, Université Paris Saclay, AP-HP, 78 Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-019-2344-6DOI Listing
February 2019

Protective effect of salvianolic acid B against oxidative injury associated with cystine stone formation.

Urolithiasis 2019 Feb 18. Epub 2019 Feb 18.

Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, China.

The aim of this study was to investigate the role of oxidative stress in cystine crystal formation and whether salvianolic acid B, a natural antioxidant, could prevent cystine-mediated oxidative injury in vivo and in vitro. The levels of oxidative stress and antioxidase activity in cystine stone patients were assessed. Then, the oxidative stress exerted by cystine on human kidney-2 (HK-2) cell viability and biochemical parameters including antioxidase activity and antioxidant protein expression were evaluated, and the protective action of salvianolic acid B was also examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00240-019-01114-4DOI Listing
February 2019

Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?

Oxid Med Cell Longev 2019 15;2019:9109473. Epub 2019 Jan 15.

Department of Nephrology, Medical School, University of Ioannina, Ioannina, Greece.

The disruption of balance between production of reactive oxygen species and antioxidant systems in favor of the oxidants is termed oxidative stress (OS). To counteract the damaging effects of prooxidant free radicals, all aerobic organisms have antioxidant defense mechanisms that are aimed at neutralizing the circulating oxidants and repair the resulting injuries. Antioxidants are either endogenous (the natural defense mechanisms produced by the human body) or exogenous, found in supplements and foods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/9109473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350615PMC
January 2019

Validation of a methodology for neuro-urological and lumbosacral stimulation studies in domestic pigs: a humanlike animal model.

J Neurosurg Spine 2019 Feb 15:1-11. Epub 2019 Feb 15.

7Neurosurgery, Pellegrin Hospital, Bordeaux, Nouvelle Aquitaine; and.

OBJECTIVESpinal cord injuries (SCIs) result in loss of movement and sensory feedback, but also organ dysfunction. Nearly all patients with complete SCI lose bladder control and are prone to kidney failure if intermittent catheterization is not performed. Electrical stimulation of sacral spinal roots was initially considered to be a promising approach for restoring continence and micturition control, but many patients are discouraged by the need for surgical deafferentation as it could lead to a loss of sensory functions and reflexes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.11.SPINE18676DOI Listing
February 2019
1 Read

Computed Tomography with Intravenous Contrast Is Not Associated with Development of Acute Kidney Injury in Severely Injured Pediatric Patients.

Am Surg 2019 01;85(1):e1-e5

Data for the incidence of acute kidney injury (AKI) related to intravenous contrast administration in the pediatric trauma population are limited. Obtaining a creatinine value before elective CT scans is a relatively accepted standard of care. We sought to determine whether there was any significant difference in the incidence of AKI between severely injured patients who received IV contrast and those who did not. Read More

View Article

Download full-text PDF

Source
January 2019
2 Reads

Computed Tomography with Intravenous Contrast Is Not Associated with Development of Acute Kidney Injury in Severely Injured Pediatric Patients.

Am Surg 2019 Jan;85(1):e1-e5

Data for the incidence of acute kidney injury (AKI) related to intravenous contrast administration in the pediatric trauma population are limited. Obtaining a creatinine value before elective CT scans is a relatively accepted standard of care. We sought to determine whether there was any significant difference in the incidence of AKI between severely injured patients who received IV contrast and those who did not. Read More

View Article

Download full-text PDF

Source
January 2019
2 Reads

Permissive hypotensive resuscitation in patients with traumatic hemorrhagic shock.

Scand J Trauma Resusc Emerg Med 2019 Feb 12;27(1):14. Epub 2019 Feb 12.

Division of Acute Care Surgery, Department of Critical Care Medicine, Kaohsiung Veterans General Hospital, 386, Da-Chung 1st Road, Kaohsiung City, 813, Taiwan.

We read the article "Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis" by Natthida Owattanapanich et al. with great interest and found it to be insightful. In our commentary, we propose possible reasons why mortality was lower in the permissive hypotension group and how the need for blood transfusion decreased in this group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13049-019-0595-5DOI Listing
February 2019

[The association between blood lipids and calcaneus bone mineral density in children and adolescents aged 6-16 years in Beijing].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):196-201

Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.

To investigate the association between blood lipid and calcaneus bone mineral density (BMD) in children and adolescents aged 6-16 years in Beijing. Children and adolescents were selected in 30 schools (8 primary schools, 21 middle schools and one 12-year education school) from Dongcheng, Tongzhou, Fangshan and Miyun districts of Beijing by using a stratified cluster sampling method from November 2017 to January 2018. A total of 14 303 students in grade 1 to 4 of primary school, grade 1 of junior and senior middle school were enrolled after excluding subjects who were not able to participate into this study due to trauma or other uncomfortable physical conditions or with missing key values or with diabetes and kidney diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.014DOI Listing
February 2019
2 Reads

[The association between body fat distribution and calcaneal bone mineral density in children and adolescents aged 6-16 years in Beijing].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):191-195

Department of Epidemiology, Capital Institute of Pediatric, Beijing 100020, China.

To understand the association between body fat distribution and calcaneal bone mineral density (BMD) in children and adolescents aged 6-16 years in Beijing. Children and adolescents were selected in 30 schools (8 primary schools, 21 middle schools and one 12-year education school) from Dongcheng, Tongzhou, Fangshan and Miyun districts of Beijing by using a stratified cluster sampling method from November 2017 to January 2018. A total of 15 030 students in grade 1 to 4 of primary school, grade 1 of junior and senior middle school were enrolled after excluding subjects who were not able to participate into this study due to trauma or other uncomfortable physical conditions or with missing key values or with diabetes and kidney diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.013DOI Listing
February 2019

Pediatric Blunt Renal Trauma Practice Management Guidelines: Collaboration between the Eastern Association for the Surgery of Trauma and the Pediatric Trauma Society.

J Trauma Acute Care Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Surgery, Division of Pediatric Surgery, University of Kentucky, Lexington, Kentucky.

Background: Injury to the kidney from either blunt or penetrating trauma is the most common urinary tract injury. Children are at higher risk of renal injury from blunt trauma than adults, but no pediatric renal trauma guidelines have been established. The authors reviewed the literature to guide clinicians in the appropriate methods of management of pediatric renal trauma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000002209DOI Listing
February 2019
2 Reads

Perforated appendicitis in the setting of a massive ventral hernia, morbid obesity, and multiple severe comorbidities: challenges in acute management.

Trauma Surg Acute Care Open 2019 24;4(1):e000243. Epub 2019 Jan 24.

Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

A 57-year-old woman with morbid obesity (body mass index [BMI] of 43), systemic lupus on steroids, type 2 insulin-dependent diabetes, peripheral vascular disease, unprovoked pulmonary embolism on rivaroxaban, and hypertension presented with 3 days of worsening abdominal pain and nausea. She had an extensive surgical history including a cesarean section, multiple laparotomies for small bowel obstructions (one complicated by bowel perforation requiring resection), and a double-barrelled ileostomy, which had been since reversed. As a result, she had a massive incisional hernia (figure 1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/tsaco-2018-000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347851PMC
January 2019
1 Read

Is fluid resuscitation the "Keyser Soze" of acute kidney injury in trauma patients?

Crit Care 2019 Feb 8;23(1):35. Epub 2019 Feb 8.

Intensive Care Unit, Poissy Saint Germain Hospital, 9-10 rue du champ Gaillard, 78300, Poissy, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-019-2333-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367830PMC
February 2019

Emphysematous Pyelonephritis Following Ureterovesical Reimplantation for Congenital Obstructive Megaureter. Pediatric Case Report and Review of the Literature.

Front Pediatr 2019 24;7. Epub 2019 Jan 24.

Pediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Emphysematous pyelonephritis (EPN) is a rare, life-threatening necrotizing infection of the kidney. To date, very few cases of EPN have been described in the pediatric age. The first case of EPN in a toddler occurring after ureterovesical reimplantation for congenital obstructive megaureter is reported with a literature review. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fped.2019.00002/
Publisher Site
http://dx.doi.org/10.3389/fped.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354553PMC
January 2019
7 Reads

Increasing Enteral Protein Intake in Critically Ill Trauma and Surgical Patients.

Nutr Clin Pract 2019 Feb 7. Epub 2019 Feb 7.

Harborview Injury Prevention and Research Center, Seattle, Washington, USA.

Background: Published guidelines recommend providing at least 2 g/kg/d of protein for critically ill surgical patients. It may be difficult to achieve this level of intake using standard enteral formulas, thus necessitating protein or amino acid supplementation. Herein, we report our approach to enteral protein supplementation and its relationship with urinary nitrogen excretion and serum transthyretin concentrations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ncp.10256DOI Listing
February 2019

Relationship Between level of heart type Fatty Acid binding protein (Before and After Procedures) with Acute Renal Failure after PCI in Patients under PCI.

Cardiovasc Hematol Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz. Iran.

Background & Objective: Acute renal failure (AKI) is one of the most important complications of PCI. Due to delay in creatinine increase, we need specific factors to detect AKI earlier. The aim of this study is to evaluate the valuable factors with a focus on (HFAB-P) that can be predictive for AKI after Percutaneous Coronary Intervention (PCI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871529X19666190206153012DOI Listing
February 2019

Acute kidney injury in trauma patients admitted to the ICU: a systematic review and meta-analysis.

Intensive Care Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Anaesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital Ullevål, Oslo, Norway.

Purpose: To perform a systematic review and meta-analysis of acute kidney injury (AKI) in trauma patients admitted to the intensive care unit (ICU).

Methods: We conducted a systematic literature search of studies on AKI according to RIFLE, AKIN, or KDIGO criteria in trauma patients admitted to the ICU (PROSPERO CRD42017060420). We searched PubMed, Cochrane Database of Systematic Reviews, UpToDate, and NICE through 3 December 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00134-019-05535-yDOI Listing
February 2019
1 Read

Donor characteristics, recipient outcomes, and histologic findings of kidney allografts with diffuse donor-derived glomerular fibrin thrombi.

Transplantation 2019 Jan 30. Epub 2019 Jan 30.

Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, CA, USA.

Background: Limited data is available regarding whether donor kidneys with diffuse glomerular fibrin thrombi (GFT) are safe to use. In this study, the clincopathologic characteristics of allografts with diffuse donor-derived GFT were examined.

Methods: All deceased donor kidney transplant implantation biopsies from our institution between 07/2011 to 02/2018 with diffuse GFT were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000002578DOI Listing
January 2019
2 Reads

The value of volume substitution in patients with septic and haemorrhagic shock with respect to the microcirculation.

Swiss Med Wkly 2019 Jan 4;149:w20007. Epub 2019 Feb 4.

Departement für Anästhesie, Operative Intensivbehandlung, präklinische Notfallmedizin und Schmerztherapie, Universitätsspital Basel, Departement klinische Forschung, Universität Basel, Switzerland.

After decades of ordinary scientific interest, fluid resuscitation of patients with septic and haemorrhagic shock took centre stage in intensive care research at the turn of the millennium. By that time, resuscitation fluids were the mainstay of haemodynamic stabilisation, avoidance of vasopressors and treatment of hypovolaemia in patients in shock, but were accompanied by adverse events such as excessive tissue oedema. With the spread of early goal-directed therapy research intensified and it was realised that type, volume and timing of resuscitation fluids might affect the course and outcome of critically ill patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4414/smw.2019.20007DOI Listing
January 2019
3 Reads

[Experience in the conservative treatment of renal trauma].

Cir Pediatr 2019 Jan 21;32(1):6-10. Epub 2019 Jan 21.

Servicio de Urología infantil. Hospital Universitari i Politècnic la Fe. Valencia.

Objective: The management of renal trauma has been changing in recent years so that nowadays, even in high grades, an initial conservative treatment is advocated. The aim of this work is to review the presentation, initial attitude and evolution of the renal traumas treated in our institution.

Material And Methods: Retrospective review of patients with renal trauma treated at our institution in the last 10 years. Read More

View Article

Download full-text PDF

Source
January 2019
2 Reads

Effect of Kangxianling Decoction on Expression of TGF-1/Smads and Extracellular Matrix Deposition.

Authors:
Jing Ji Liqun He

Evid Based Complement Alternat Med 2019 1;2019:5813549. Epub 2019 Jan 1.

Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Kangxianling (KXL) decoction is a traditional Chinese herbal formulation which has been used to treat early and midterm chronic renal failure. Renal fibrosis is a common characteristic of progressive chronic kidney diseases (CKD). The formation of renal fibrosis is caused by kidney trauma, infection, and immune response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/5813549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332943PMC
January 2019

Pilates exercises and quality of life of patients with chronic kidney disease.

Complement Ther Clin Pract 2019 Feb 1;34:35-40. Epub 2018 Nov 1.

Autoimmune Diseases Research Center, Department of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Background And Purpose: There is a need to investigate the effects of pilates exercises on the quality of life (QOL) of patients with chronic kidney diseases (CKD). The purpose of this study was to determine the effect of pilates exercises on the QOL of CKD patients.

Materials And Methods: For this randomized controlled clinical trial, we enrolled 50 CKD patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctcp.2018.10.017DOI Listing
February 2019

Activation of the cannabinoid CB2 receptor increases renal perfusion.

Physiol Genomics 2019 Feb 1. Epub 2019 Feb 1.

Pharmaceutical Sciences, University of Tennessee Health Sciences Center, United States.

Acute kidney injury (AKI) is an increasing problem clinically and is associated with chronic kidney disease progression. Cannabinoid type 2 receptor activation has been shown to mitigate some of the deleterious tubular effects due to AKI, but its role on the renal vasculature has not been fully described. In this study, we investigated the effects of our novel cannabinoid CB2 receptor agonist, SMM-295, on renal vasculature by assessing cortical perfusion using laser Doppler flowmetry and changes in luminal diameter using isolated afferent arterioles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00001.2019DOI Listing
February 2019

Factors associated with renal Doppler resistive index in critically ill patients: a prospective cohort study.

Ann Intensive Care 2019 Jan 31;9(1):23. Epub 2019 Jan 31.

Emergency Medicine Discipline, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av Enéas de Carvalho Aguiar 255 Sala 5023, São Paulo, SP, Postal Code: 05403-000, Brazil.

Background: The renal Doppler resistive index (renal RI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. However, many parameters have been described as influential on the values of renal RI. Therefore, we proposed this study to evaluate the variables that could impact renal RI in critically ill patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13613-019-0500-4DOI Listing
January 2019

Renal trauma: a 3-year audit from a Gold Coast trauma centre.

ANZ J Surg 2019 Jan 30. Epub 2019 Jan 30.

Department of Surgery, Gold Coast University Hospital, Gold Coast, Queensland, Australia.

Background: Limited data Exists ? on the Australian epidemiology of renal trauma, with very few studies published in the literature. The authors aim to detail the trends of renal trauma in the coastal city of the Gold Coast.

Methods: Retrospective data collection yielded 81 patients who sustained renal trauma from our 3-year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ans.15026DOI Listing
January 2019
2 Reads

Does β-caryophyllene protect against renal dysfunction following ischemia-reperfusion injury in the rat?

Int J Physiol Pathophysiol Pharmacol 2018 25;10(6):163-171. Epub 2018 Dec 25.

Department of Surgery, College of Medicine & Health Sciences, United Arab Emirates University Al Ain, United Arab Emirates.

Introduction: Renal ischemia-reperfusion injury (IRI) causes renal functional alterations which may lead to permanent renal impairment. β-caryophyllene (BCP), a natural bicyclic sesquiterpene, is an important constituent of many edible plants including spices. It is an FDA-approved food additive which possesses potent anti-inflammatory and antioxidant activities and has been shown to protect against chemotherapeutics-induced organ toxicities and against ischemic injuries to heart, liver and brain. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334221PMC
December 2018

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.

Cell Death Dis 2019 Jan 28;10(2):78. Epub 2019 Jan 28.

Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Renal fibrosis is the final common pathway of various renal injuries and it leads to chronic kidney disease. Autophagy is a cellular process of degradation of damaged cytoplasmic components and regulates cell death and proliferation. Cellular response during unilateral ureteral obstruction (UUO) is tubular segment specific. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-019-1356-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349890PMC
January 2019
1 Read
5.014 Impact Factor

Development of a national minimum data set to monitor deceased organ donation performance in Canada.

Can J Anaesth 2019 Jan 28. Epub 2019 Jan 28.

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Purpose: Deceased donation data requires standardization to enable accurate interprovincial and international comparisons of deceased donation performance. In Canada, most provincial organ donation organizations (ODOs) have developed different processes and infrastructures for referring potential donors and subsequent data collection. This has led to differing definitions of the performance measures used for each step in the donation process, from potential donor identification to consent to transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12630-018-01290-8DOI Listing
January 2019
1 Read

A scrutiny of circulating microRNA biomarkers for drug-induced tubular and glomerular injury in rats.

Toxicology 2019 Mar 22;415:26-36. Epub 2019 Jan 22.

Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagaya 466-8550, Japan. Electronic address:

Drug-induced acute kidney injury (AKI) is a frequent cause of adverse drug reaction. Serum creatinine (CRE) and blood urea nitrogen (BUN) are widely used as standard biomarkers for kidney injury; however, the sensitivity and specificity are considered to be low. In recent years, circulating microRNA (miRNAs) have been attracting considerable attention as novel biomarkers for organ injury, but there are currently no established miRNA biomarkers for drug-induced AKI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tox.2019.01.011DOI Listing
March 2019
2 Reads

Trauma induced acute kidney injury.

PLoS One 2019 25;14(1):e0211001. Epub 2019 Jan 25.

St Bartholomew's Hospital and Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.

Background: Injured patients are at risk of developing acute kidney injury (AKI), which is associated with increased morbidity and mortality. The aim of this study is to describe the incidence, timing, and severity of AKI in a large trauma population, identify risk factors for AKI, and report mortality outcomes.

Methods: A prospective observational study of injured adults, who met local criteria for trauma team activation, and were admitted to a UK Major Trauma Centre. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211001PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347290PMC
January 2019
5 Reads

Intravenous injection of post-hemorrhagic shock mesenteric lymph induces multiple organ injury in rats.

Exp Ther Med 2019 Feb 5;17(2):1449-1455. Epub 2018 Dec 5.

Institute of Microcirculation, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China.

Post-hemorrhagic shock mesenteric lymph (PHSML) has an important role in the multiple organ injuries caused by severe shock. The current study investigated whether intravenous injection of PHSML induces organ injury in normal rats. Following the establishment of hemorrhagic shock in donor rats (40±2 mmHg, 3 h), PHSML was drained during hypotension at 1-3 h and then injected to normal rats through the femoral vein within 30 min. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2018.7048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327623PMC
February 2019
1 Read

First description of a fatal equine infection with Halicephalobus gingivalis in Portugal. Relevance for public health.

Vet Med Sci 2019 Jan 22. Epub 2019 Jan 22.

CIISA, Interdisciplinary Centre of Research in Animal Health, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, Lisbon, Portugal.

Halicephalobus gingivalis is a small saprophytic rhabditid nematode, represented only by females with a typical rhabditoid oesophagus and one egg in the uterus, capable of infecting vertebrates. This opportunistic parasite present in the soil, manure and decaying humus, is thought to penetrate through previous injuries to the mouth, eyes and skin of horses and migrate to various organs. The brain is one such organ, where the females lay their eggs, leading to malacia and causing a sudden onset of neurological signs, such as anorexia, ataxia, urinary incontinence, blindness, decreased menace and tonal reflexes, tremors and aggressiveness. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/vms3.142
Publisher Site
http://dx.doi.org/10.1002/vms3.142DOI Listing
January 2019
3 Reads

23.4% Hypertonic Saline and Intracranial Pressure in Severe Traumatic Brain Injury Among Children: A 10-Year Retrospective Analysis.

Pediatr Crit Care Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Pediatrics, Hennepin Healthcare, Minneapolis, MN.

Objective: To explore the effect of 23.4% hypertonic saline for management of elevated intracranial pressure in children admitted to our institution for severe traumatic brain injury.

Design: Single-center, retrospective medical chart analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PCC.0000000000001867DOI Listing
January 2019
3 Reads
2.338 Impact Factor

Exosomes from human umbilical cord mesenchymal stem cells enhance fracture healing through HIF-1α-mediated promotion of angiogenesis in a rat model of stabilized fracture.

Cell Prolif 2019 Jan 20:e12570. Epub 2019 Jan 20.

Department of Emergency and Trauma, Shanghai Changhai Hospital Affiliated to the Second Military Medical University, Shanghai, China.

Objectives: Exosomes, as important players in intercellular communication due to their ability to transfer certain molecules to target cells, are believed to take similar effects in promoting bone regeneration with their derived stem cells. Studies have suggested that umbilical cord mesenchymal stem cells (uMSCs) could promote angiogenesis. This study investigated whether exosomes derived from uMSCs (uMSC-Exos) could enhance fracture healing as primary factors by promoting angiogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cpr.12570DOI Listing
January 2019
2 Reads

Assessment of acute kidney injury in neurologically and traumatically injured intensive care patients receiving large vancomycin doses.

Int J Crit Illn Inj Sci 2018 Oct-Dec;8(4):194-200

Department of Pharmacy, University of Alabama at Birmingham Medical Center, Birmingham, AL, USA.

Background: Previous reports note that in a mixed patient population, vancomycin doses >4 g/day are associated with increased rates of acute kidney injury (AKI).

Objective: The objective of the study is to determine if vancomycin regimens >4 g/day are associated with a higher incidence of AKI in neurocritical care unit (NCCU) and trauma/burn Intensive Care Unit (TBICU) patients.

Materials And Methods: This single-centered, retrospective study enrolled adult patients initiated on vancomycin in the NCCU and TBICU at an academic medical center during 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJCIIS.IJCIIS_39_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311967PMC
January 2019
1 Read

Organ transplantation and gut microbiota: current reviews and future challenges.

Am J Transl Res 2018 15;10(11):3330-3344. Epub 2018 Nov 15.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology 13 Hangkong Road, Wuhan 430030, China.

Organ transplantation is often the only effective treatment for patients with end-stage diseases, such as heart, liver, kidney and small bowel failure and is carried out frequently worldwide. Still the post-transplantation complications remain health- and life-threatening outcome that needed to be resolved. With the rapid development of molecular technologies in recent years, more and more researchers realize that the gut microbiota may play a critical role in human diseases. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291689PMC
November 2018
6 Reads

[A CASE OF RETROPERITONEAL HEMORRHAGE CAUSED BY THE INSERTION OF A URETERAL ACCESS SHEATH. A RARE COMPLICATION ASSOCIATED WITH FLEXIBLE TRANSURETHRAL LITHOTRIPSY (fTUL)].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):50-53

Department of Urology, Toyohashi Municipal Hospital.

A 77-year-old man with a right kidney stone was admitted to our hospital. A ureteroscope was introduced into the ureter without dilation under direct vision. We then performed flexible transurethral lithotripsy (f-TUL) using a ureteral access sheath and successfully fragmented the stone and extracted almost all the stone fragments without any complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5980/jpnjurol.109.50DOI Listing
February 2019
2 Reads

Autophagy in Chronic Kidney Diseases.

Cells 2019 Jan 16;8(1). Epub 2019 Jan 16.

Department of Cardiology, Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan City 333, Taiwan.

Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activations and inhibitions are linked to acute kidney injuries, chronic kidney diseases, diabetic nephropathies, and polycystic kidney diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells8010061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357204PMC
January 2019
2 Reads

Migration of an intrauterine device causing severe hydronephrosis progressing to renal failure: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e13872

Department of Obstetrics and Gynecology, People's Hospital of Zhengzhou University.

Rationale: Intrauterine device (IUD) is commonly used in China. Its complications include uterine perforation, IUD ectopic migration, etc. However, a migrated IUD rarely leads to renal failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000013872DOI Listing
January 2019
2 Reads

Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity.

Stem Cells Int 2018 16;2018:8693137. Epub 2018 Dec 16.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

A kidney has the ability to regenerate itself after a variety of renal injuries. Mesenchymal stem cells (MSCs) have been shown to ameliorate tissue damages during renal injuries and diseases. The regenerations induced by MSCs are primarily mediated by the paracrine release of soluble factors and extracellular vesicles, including exosomes and microvesicles. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/sci/2018/8693137/
Publisher Site
http://dx.doi.org/10.1155/2018/8693137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311717PMC
December 2018
4 Reads

Epidemiology and Outcomes of Acute Kidney Injury in Critically Ill: Experience from a Tertiary Care Center.

Indian J Nephrol 2018 Nov-Dec;28(6):413-420

Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

There is only limited information on the epidemiology and outcomes of acute kidney injury (AKI) in critically ill patients from low- and middle-income countries. This study aims to identify the etiology, short-term outcomes, and determinants of mortality in patients with AKI admitted to multiple medical and surgical Intensive Care Units (ICU's) in a tertiary care center. The study also aims to compare the clinical characteristics and outcomes of community-acquired AKI (CAAKI) and hospital-acquired AKI (HAAKI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijn.IJN_191_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309393PMC
January 2019
1 Read

Barriers and Advances in Kidney Preservation.

Biomed Res Int 2018 4;2018:9206257. Epub 2018 Dec 4.

Inserm U1082, Poitiers, F-86000, France.

Despite the fact that a significant fraction of kidney graft dysfunctions observed after transplantation is due to ischemia-reperfusion injuries, there is still no clear consensus regarding optimal kidney preservation strategy. This stems directly from the fact that as of yet, the mechanisms underlying ischemia-reperfusion injury are poorly defined, and the role of each preservation parameter is not clearly outlined. In the meantime, as donor demography changes, organ quality is decreasing which directly increases the rate of poor outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/9206257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311271PMC
December 2018

Porous Se@SiO nanospheres attenuate ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) and inflammation by antioxidative stress.

Int J Nanomedicine 2019 27;14:215-229. Epub 2018 Dec 27.

Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Objectives: Acute kidney injury (AKI) is a growing global health concern, and is associated with high rates of mortality and morbidity in intensive care units. Se is a trace element with antioxidant properties. This study aimed to determine whether porous Se@SiO nanospheres could relieve oxidative stress and inflammation in ischemia/reperfusion (I/R)-induced AKI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S184804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312062PMC
February 2019
1 Read

MicroRNA-29a Attenuates Diabetic Glomerular Injury through Modulating Cannabinoid Receptor 1 Signaling.

Molecules 2019 Jan 11;24(2). Epub 2019 Jan 11.

Department of Nephrology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.

Diabetic nephropathy often leads to end-stage renal disease and life-threatening morbidities. Simple control of risk factors is insufficient to prevent the progression of diabetic nephropathy, hence the need for discovering new treatments is of paramount importance. Recently, the dysregulation of microRNAs or the cannabinoid signaling pathway has been implicated in the pathogenesis of various renal tubulointerstitial fibrotic damages and thus novel therapeutic targets for chronic kidney diseases have emerged; however, the role of microRNAs or cannabinoid receptors on diabetes-induced glomerular injuries remains to be elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24020264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359641PMC
January 2019
4 Reads

Renal chymase-dependent pathway for angiotensin II formation mediated acute kidney injury in a mouse model of aristolochic acid I-induced acute nephropathy.

PLoS One 2019 11;14(1):e0210656. Epub 2019 Jan 11.

Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.

Angiotensin-converting enzyme (ACE) is the primary enzyme that converts angiotensin I (Ang I) to angiotensin II (Ang II) in the renin-angiotensin system (RAS). However, chymase hydrates Ang I to Ang II independently of ACE in some kidney diseases, and it may play an important role. The present study investigated whether chymase played a crucial role in aristolochic acid I (AAI)-induced nephropathy. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210656PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329531PMC
January 2019

Coxsackie B Virus Infection as a rare cause of Acute Renal Failure and Hepatitis.

Kathmandu Univ Med J (KUMJ) 2018 Jan.-Mar;16(61):100-102

Department of Nephrology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.

We report a 37 year female patient, admitted with complains of fever, jaundice and myalgia of seven days. There was no history of trauma, drug abuse, seizure or vigorous exercise nor history of renal and musculoskeletal disease. Here we have discussed the clinical features, biochemical derangements, diagnosis of coxsackie B virus, multi organ involvement and need of urgent hemodialysis for appropriate management of the case. Read More

View Article

Download full-text PDF

Source
February 2019
1 Read

[Acute abdominal trauma].

Radiologe 2019 Feb;59(2):139-145

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, Nußbaumstr. 20, 80336, München, Deutschland.

Background: In patients with multiple trauma, abdominal involvement is a particularly relevant injury pattern. Depending on the intensity and manner of injury, heterogeneous but often typical organ manifestations result. Knowledge of these injury patterns is essential for targeted diagnostics and treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00117-018-0485-2DOI Listing
February 2019