832,606 results match your criteria Kidney & blood pressure research[Journal]


Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois.

Background: Prostatic inflammation and various proinflammatory systemic comorbidities, such as diabetes and obesity are associated with human benign prostatic hyperplasia (BPH). There is a paucity of in vivo models reflecting specific aspects of BPH pathogenesis. Our aim was to investigate the nonobese diabetic (NOD) mouse as a potential model for subsequent intervention studies. Read More

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http://dx.doi.org/10.1002/pros.23809DOI Listing
April 2019
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How Effective Is Retrograde Semirigid and Flexible Ureteroscopic Lithotripsy for the Treatment of Large Ureteral Stones Equal of or Greater than 15 mm? Results from a Single Center.

Urol Int 2019 Apr 18:1-7. Epub 2019 Apr 18.

Department of Urology, General Hospital of Volos "Achillopouleio", Volos, Magnesia, Greece.

Purpose: To present the results and complications of retrograde ureteroscopic lithotripsy for treatment of large ureteral stones.

Methods: Nineteen patients were treated for ureteral stones ≥15 mm detected in CT or plain KUB film. Endoscopy was performed with either a semirigid or flexible ureteroscope. Read More

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http://dx.doi.org/10.1159/000499573DOI Listing

Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?

Nephron 2019 Apr 18:1-5. Epub 2019 Apr 18.

Department of Anaesthesiology, Critical Care Medicine and Burn unit, AP-HP, Saint Louis University Hospitals, Paris, France,

The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade leading to the synthesis of angiotensin 2. The activation of the RAAS system after acute kidney injury triggers renal inflammation and fibrotic process with long-term damaging consequences. To date, there is still a debate on the benefits of RAAS for the kidney in acute settings. Read More

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http://dx.doi.org/10.1159/000499940DOI Listing

Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 3;1117:49-57. Epub 2019 Apr 3.

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Changes in metabolites composition can reflect currently present pathological processes in a living organism and constitute a basis for diagnosis and treatment improvements. Thus, the multiplatform metabolomics approach was applied for the investigation of molecular mechanisms of chronic kidney disease (CKD) progression. The high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ/MS) serum metabolic fingerprinting followed by uni- and multivariate statistical analysis was carried out to determine metabolic pattern differentiating CKD patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.003DOI Listing

Molecular cloning and mRNA expression of IFIT5 in tissues of ducklings infected with virulent duck hepatitis A virus type 3.

Res Vet Sci 2019 Apr 8;124:256-262. Epub 2019 Apr 8.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, Heilongjiang Province, PR China; Northeastern Science Inspection Station, China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of proteins strongly induced downstream of type I interferon signaling. The function of IFITs has been investigated extensively in mammals. IFIT5 is the sole protein in this family found in birds and little information is available about the function of avian IFIT5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183132
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http://dx.doi.org/10.1016/j.rvsc.2019.04.003DOI Listing
April 2019
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Solitary contralateral adrenal metastasis of renal cell carcinoma 15 years following radical nephrectomy: A case report and review of literature.

Int J Surg Case Rep 2019 Apr 5;58:33-36. Epub 2019 Apr 5.

University of Sulaymaniyah, Faculty of Medical Sciences, School of Medicine, Department of Radiology, Iraq.

Introduction: Renal cell carcinoma (RCC) is known to metastasize to almost every organ. A well-recognized phenomenon in RCC is late metastatic recurrence after nephrectomy which is arbitrarily defined as more than 10 years. The incidence of solitary ipsilateral and contralateral adrenal metastasis is 3% and 0. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.049DOI Listing

Molecular characterization of manganese superoxide dismutase (MnSOD) from sterlet Acipenser ruthenus and its responses to Aeromonas hydrophila challenge and hypoxia stress.

Comp Biochem Physiol A Mol Integr Physiol 2019 Apr 15. Epub 2019 Apr 15.

National Freshwater Fisheries Engineering Technology Research Center, Ministry of Science and Technology of China, Beijing Key Laboratory of Fishery Biotechnology (No.BZ0301), Beijing Fisheries Research Institute, Beijing 100068, China. Electronic address:

A novel gene encoding the mitochondrial manganese superoxide dismutase from sterlet Acipenser ruthenus (Ar-MnSOD) was cloned. The full-length cDNA of MnSOD was of 1040 bp with a 672 bp open reading frame encoding 224 amino acids and the deduced amino acid sequence was located in mitochondria. Sequence comparison analysis showed that Ar-MnSOD was highly similar to MnSODs of invertebrates and vertebrates, especially those of freshwater Cyprinidae fishes and mammals. Read More

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http://dx.doi.org/10.1016/j.cbpa.2019.04.010DOI Listing

Feed and immersion challenges with lymphocystis disease virus (LCDV) reveals specific mechanisms for horizontal transmission and immune response in senegalese sole post-larvae.

Fish Shellfish Immunol 2019 Apr 15. Epub 2019 Apr 15.

IFAPA Centro El Toruño, Junta de Andalucía, Camino Tiro Pichón s/n, 11500, El Puerto de Santa María, Cádiz, Spain. Electronic address:

The horizontal transmission of lymphocystis disease virus (LCDV) through contaminated water and feed (using artemia as vehicle) and the associated immune gene expression profiles in Senegalese sole post-larvae were investigated. All specimens analyzed were positive for LCDV DNA detection at 1-day post-challenge (1 dpc) with the highest viral levels in specimens infected through the immersion route. However, the percentage of LCDV-positive animals and number of viral DNA copies dropped progressively at 2 and 7 dpc. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.049DOI Listing

Leaves and stems of Capparis erythrocarpos, more sustainable than roots, show antiarthritic effects.

J Ethnopharmacol 2019 Apr 15:111890. Epub 2019 Apr 15.

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Ethnopharmacological Relevance: Capparis erythrocarpos is a medicinal plant used widely in many parts of Africa for the management of pain and inflammatory conditions such as rheumatoid arthritis. Its wide range of use, popularity and high value, make C. erythrocarpos containing products a target for economically driven adulteration. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111890DOI Listing

Abnormal Chest Radiograph in Rapidly Progressive Glomerulonephritis - Not the Usual Pulmonary-Renal Syndrome.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Renal Medicine, Singapore General Hospital. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.03.038DOI Listing

Chronic Kidney Disease in Agricultural Communities.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Informatics, The Ohio State University. Electronic address:

Patients residing in agricultural communities have a high risk of developing chronic kidney disease. In the Great Plains, geo-environmental risk factors (variable climate, temperature, air quality, water quality and drought) combine with agro-environmental risk factors (exposure to fertilizers, soil conditioners, herbicides, fungicides and pesticides) to increase risk for toxic nephropathy. However, research defining the specific influence of agricultural chemicals on the progression of kidney disease in rural communities has been somewhat limited. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.03.036DOI Listing

Individual Differences in Behavioral Responses to Palatable Food or to Cholecystokinin Predict Subsequent Diet-Induced Obesity.

Obesity (Silver Spring) 2019 Apr 18. Epub 2019 Apr 18.

Graduate Group in Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Objective: This study investigated whether individual differences in behavioral responses to palatable food and to the satiation signal cholecystokinin (CCK) in outbred chow-maintained Sprague-Dawley rats enabled prediction of individual differences in weight gained after subsequent high-fat/high-sugar diet (HFHSD) maintenance.

Methods: Meal size, meal number, and early dark cycle intake during initial HFHSD exposure were measured, as were early dark cycle sucrose solution and chow intake, chow meal size and meal number, the intake-suppressive effects of 0.5-µg/kg CCK injection, and CCK-induced c-Fos activation in the nucleus tractus solitarius. Read More

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http://dx.doi.org/10.1002/oby.22459DOI Listing

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice.

PLoS One 2019 18;14(4):e0211559. Epub 2019 Apr 18.

Kidney Disease Section, NIDDK, NIH, Bethesda, Maryland, United States of America.

Apolipoprotein L1 (APOL1) genetic variants G1 and G2, compared to the common allele G0, are major risk factors for non-diabetic kidney disease in African descent populations. APOL1 is a minor protein component of HDL, as well as being expressed in podocytes and vascular cells. Reverse cholesterol transport involves the transport of cholesterol to HDL by cellular ATP-binding cassette; ABCA1 and ABCG1 with subsequent delivery from peripheral tissues to the liver. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211559PLOS

Development of a novel linear model for predicting recipient's post-transplant serum creatinine level after living donor kidney transplantation: A multicenter cross-validation study.

PLoS One 2019 18;14(4):e0214247. Epub 2019 Apr 18.

Department of Surgery, Seoul National University College of Medicine, Seoul Korea.

Background: This study was designed to develop and cross-validate a statistical model for predicting post-transplant serum creatinine of living donor kidney transplantation.

Materials And Methods: Adult recipients of living donor kidney transplantation from August 2012 to October 2017 at Samsung Medical Center (SMC) and Seoul National University Hospital (SNUH) with normal post-transplant protocol biopsy were included for modelling. Demographic data including recipient and donor's sex, age, body measurements and comorbidities, pre-transplant donor serum creatinine, graft weight, post-transplant recipient serum creatinine and the result of protocol biopsy were collected. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214247PLOS

XGBoost Model for Chronic Kidney Disease Diagnosis.

IEEE/ACM Trans Comput Biol Bioinform 2019 Apr 17. Epub 2019 Apr 17.

Chronic Kidney Disease (CKD) is a menace that is affecting 10% of the world population and 15% of the South African population. The early and cheap diagnosis of this disease with accuracy and reliability will save 20,000 lives in South Africa per year. Scientists are developing smart solutions with Artificial Intelligence (AI). Read More

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http://dx.doi.org/10.1109/TCBB.2019.2911071DOI Listing

Favorable Bioactivity of the SDHI Fungicide Benzovindiflupyr Against Mycelial Growth, Sclerotial Production, and Myceliogenic and Carpogenic Germination of Sclerotia.

Plant Dis 2019 Apr 17:PDIS05180729RE. Epub 2019 Apr 17.

1 Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai'an, Shandong 271018, P. R. China.

, which can cause Sclerotinia stem rot, is a prevalent plant pathogen. This study aims to evaluate the application potential of benzovindiflupyr, a new generation of succinate dehydrogenase inhibitor (SDHI), against . In our study, 181 isolates collected from different crops (including eggplant [ = 34], cucumber [ = 27], tomato [ = 29], pepper [ = 35], pumpkin [ = 32], and kidney bean [ = 25]) in China were used to establish baseline sensitivity to benzovindiflupyr. Read More

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http://dx.doi.org/10.1094/PDIS-05-18-0729-REDOI Listing

Assessing alignment between functional markers and ordinal outcomes based on broad sense agreement.

Biometrics 2019 Apr 18. Epub 2019 Apr 18.

Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia.

Functional markers and their quantitative features (eg, maximum value, time to maximum, area under the curve [AUC], etc) are increasingly being used in clinical studies to diagnose diseases. It is thus of interest to assess the diagnostic utility of functional markers by assessing alignment between their quantitative features and an ordinal gold standard test that reflects the severity of disease. The concept of broad sense agreement (BSA) has recently been introduced for studying the relationship between continuous and ordinal measurements, and provides a promising tool to address such a question. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/biom.13063
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http://dx.doi.org/10.1111/biom.13063DOI Listing
April 2019
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Efficacy and safety of 20% albumin fluid loading in healthy subjects: a comparison of four resuscitation fluids.

J Appl Physiol (1985) 2019 Apr 18. Epub 2019 Apr 18.

Flinders University, Australia.

Recently, buffered salt solutions and 20% albumin (small volume resuscitation) have been advocated as an alternative fluid for intravenous resuscitation. The relative comparative efficacy and potential adverse effects of these solutions have not been evaluated. In a randomized, double blind, cross over study of 6 healthy male subjects we compared the pulmonary and hemodynamic effects of intravenous administration of 30 ml/kg of 0. Read More

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http://dx.doi.org/10.1152/japplphysiol.01058.2018DOI Listing

Role of Nrf2-antioxidant in radioprotection by root extract of Inula racemosa.

Int J Radiat Biol 2019 Apr 18:1-34. Epub 2019 Apr 18.

a Division of Capacity Enhancement and Product Induction , Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization , Timarpur , Delhi , India 110054.

Purpose: Inula racemosa, a Trans-Himalayan plant is an important medicinal herb. In the present study, the radio-modulatory efficacy of aqueous root extract of I. racemosa was investigated. Read More

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http://dx.doi.org/10.1080/09553002.2019.1607607DOI Listing

Protective effects of ghrelin on kidney tissue in rats with partial ureteral obstruction

Turk J Med Sci 2019 Apr 18;49(2):696-702. Epub 2019 Apr 18.

Background/aim: The aim was to investigate the protective and therapeutic effects of ghrelin, which has antioxidant and antiinflammatory activity, on preventing kidney damage that occurs by induced partial ureteral obstruction in rats

Materials And Methods: Twenty-eight adult male rats were included in the study, and the rats were divided into 4 groups. After the laparotomy operation on the sham group, the ureter was identified in the retroperitoneal area and was duly sutured (n = 7). Ghrelin was administered for seven days intraperitoneally, and after the nephrectomy performed on the 15th day, the rats were sacrificed (n = 7). Read More

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http://dx.doi.org/10.3906/sag-1802-17DOI Listing

SGLT2 inhibition to address the unmet needs in diabetic nephropathy.

Diabetes Metab Res Rev 2019 Apr 18:e3171. Epub 2019 Apr 18.

Department of Medical Sciences, University of Turin, Turin, Italy.

Current treatment of diabetic nephropathy is effective; however, substantial gaps in care still remain and new therapies are urgently needed to reduce the global burden of the complication. Desirable properties of an "ideal" new drug should include: primary prevention of microalbuminuria, additive/synergistic anti-proteinuric effect in combination therapy with renin angiotensin system blockers, reduction of chronic kidney disease progression to lower the risk of end-stage renal disease, and cardiovascular protection. Growing evidence suggests that sodium-glucose cotransporter 2 inhibitors (SGLT2i) may fulfill many of these criteria and represent novel tools to cover the unmet needs in diabetic nephropathy care. Read More

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http://dx.doi.org/10.1002/dmrr.3171DOI Listing

Age of HIV Acquisition Affects the Risk of Multi-Morbidity after 25 Years of Infection Exposure.

J Frailty Aging 2019 ;8(2):88-92

Giovanni Guaraldi, Universita degli Studi di Modena e Reggio Emilia, Italy,

Introduction: Understanding the intersection of HIV, aging and health is crucial due to the increasing number of people aging with HIV.

Objective: The objective of the study was to assess the prevalence of, and risk factors for individual comorbidities and multi-morbidity in people living with HIV with similar duration of HIV infection, notwithstanding a 25-year difference at the time of HIV acquisition.

Methods: In a cross-sectional multicentre retrospective study, we compared three match-control age groups. Read More

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http://dx.doi.org/10.14283/jfa.2019.6DOI Listing
January 2019

Prevalence of nervous necrosis virus (NNV) and Streptococcus species in wild marine fish and crustaceans from the Levantine Basin, Mediterranean Sea.

Dis Aquat Organ 2019 Feb;133(1):7-17

Morris Kahn Marine Research Station, Department of Marine Biology, Leon H. Charney School of Marine Sciences, University of Haifa, 3498838, Israel.

Infectious diseases in marine animals have ecological, socio-economic and environmental impacts. Nervous necrosis virus (NNV) and Streptococcus iniae have become major threats to marine aquaculture and have been detected in morbid marine organisms worldwide. However, despite their importance, there is a lack of knowledge regarding the prevalence of these pathogens in wild fish species. Read More

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http://dx.doi.org/10.3354/dao03339DOI Listing
February 2019

Expression patterns and prognostic value of miR-210, miR-494, and miR-205 in middle-aged and old patients with sepsis-induced acute kidney injury.

Bosn J Basic Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Department of Intensive Care Unit, Sir Run Run Shaw Hospital, Medicine School of Zhejiang University, Hangzhou, China.

Septic patients suffer a 'cytokine storm' from proinflammatory cytokines, chemokines and other inflammatory mediators, resulting in acute kidney injury (AKI) and death. The purpose of the present study was to determine the expression patterns of microRNA-210 (miR-210), miR-494, and miR-205 in middle-aged and old patients with sepsis-induced AKI and to evaluate their association with patient prognosis. Serum blood urea nitrogen (BUN), creatinine (Cr) and cystatin C levels were determined in peripheral venous blood collected from 110 patients with sepsis-induced AKI and 110 healthy controls. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4131DOI Listing

Assessing the nephrotoxicity of intravenous iodinated contrast agents in patients with chronic renal failure in the absence of interfering acute disease.

Acta Radiol 2019 Apr 18:284185119840764. Epub 2019 Apr 18.

1 Department of Radiology, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Sabadell, Spain.

Background: The existence of contrast-induced nephropathy is widely accepted. Recent studies suggest its incidence has been overestimated.

Purpose: To determine the effect of intravenous iodinated contrast agents on renal function in patients with chronic renal failure without acute disease that can interfere with the assessment of renal function. Read More

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http://dx.doi.org/10.1177/0284185119840764DOI Listing

Mild to moderate proteinuria is a heralding sign for acute kidney injury and mortality for intensive care unit patients

Turk J Med Sci 2019 Apr 18;49(2):543-550. Epub 2019 Apr 18.

Background/aim: Lack of early predictors of acute kidney injury is currently delaying timely diagnosis.This study was done to evaluate the relationship between mild to moderate proteinuria and incidence of acute kidney injury (AKI) and 28-day mortality in intensive care unit (ICU) patients.

Materials And Methods: This observational, retrospective study was conducted in the internal medicine ICU. Read More

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http://dx.doi.org/10.3906/sag-1802-183DOI Listing

Protein kinase D1 inhibition interferes with mitosis progression.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Inmunología, Genética y Metabolismo, Facultad de Farmacia y Bioquímica, Hospital de Clínicas "José de San Martín," Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires (CABA), Buenos Aires, Argentina.

Protein kinase D1 (PKD1) plays a vital role in signal transduction, cell proliferation, membrane trafficking, and cancer; however, the majority of the studies up to date had centered primarily on PKD1 functions in interphase, very little is known about its role during cell division. We previously demonstrated that during mitosis PKD1 is activated and associated with centrosomes, spindles, and midbodies. However, these observations did not address whether PKD1 was associated with mitosis regulation. Read More

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http://dx.doi.org/10.1002/jcp.28651DOI Listing

Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina.

Mol Neurobiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by electron microscopy and immunocytochemistry. We also tested cultured Müller glia for their response to S1P. Read More

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http://dx.doi.org/10.1007/s12035-019-1599-xDOI Listing

Comparative Effects of Medical Versus Surgical Weight Loss on Body Composition: a Pilot Randomized Trial.

Obes Surg 2019 Apr 17. Epub 2019 Apr 17.

Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objective: Bariatric surgery leads to more rapid and greater weight loss (WL) compared to medical weight loss (MWL), but the differences in body composition (BC) changes for these modalities remain unclear. Due to the known health risks associated with central adiposity, we compared the changes in regional distribution of fat mass (FM) and lean mass (LM) after surgical versus MWL.

Methods: In this 1:1:1 randomized trial among 15 persons with type 2 diabetes and body mass index (BMI) 30-39. Read More

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http://dx.doi.org/10.1007/s11695-019-03879-4DOI Listing

Evaluation of heat stress and cumulative incidence of acute kidney injury in sugarcane workers in Guatemala.

Int Arch Occup Environ Health 2019 Apr 17. Epub 2019 Apr 17.

Department of Environmental and Occupational Health, Center for Health, Work, and Environment Colorado School of Public Health, University of Colorado, Anschutz Medical Campus 13001 E. 17th Pl., Ste. W3111, Aurora, CO, 80045, USA.

Objective: Agricultural workers worldwide exposed to heat stress could be at the risk of kidney injury, which could lead to chronic kidney disease of an unknown origin (CKDu). Hydration has been promoted as a key measure to reduce kidney injury. In the presence of a hydration intervention, the incidence of acute kidney injury (AKI) was calculated in a sugarcane worker population in Guatemala and several risk factors were evaluated. Read More

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http://dx.doi.org/10.1007/s00420-019-01426-3DOI Listing

Capability of iturin from Bacillus subtilis to inhibit Candida albicans in vitro and in vivo.

Appl Microbiol Biotechnol 2019 Apr 17. Epub 2019 Apr 17.

Key Laboratory for Space Bioscience and Space Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi'an, 710072, Shaanxi Province, China.

Candida albicans is a fungal pathogen that is difficult to cure clinically. The current clinic C. albicans-inhibiting drugs are very harmful to humans. Read More

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http://dx.doi.org/10.1007/s00253-019-09805-zDOI Listing

[Arterioureteral fistulas in the last 10 years at the University of Lübeck].

Urologe A 2019 Apr 17. Epub 2019 Apr 17.

Klinik und Poliklinik für Urologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Introduction: Arterioureteral fistulas are rare, life-threatening, and difficult to diagnose. Risk factors are medical interventions in the lesser pelvis (general, urological, gynecological, and vascular surgery), radiation therapy of the lesser pelvis, permanent double J catheters, and previous vessel malformations.

Materials And Methods: We retrospectively evaluated all cases of arterioureteral fistulas registered over the last 10 years in the clinic's documentation system. Read More

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http://dx.doi.org/10.1007/s00120-019-0923-4DOI Listing

Challenges in urogenital tuberculosis.

World J Urol 2019 Apr 17. Epub 2019 Apr 17.

Novosibirsk Research TB Institute, Urogenital Clinic, Novosibirsk, Russian Federation.

Purpose: For better understanding of urogenital tuberculosis (UGTB), its clinical spectrum and characteristic features need to be evaluated.

Materials And Methods: One hundred and forty-two cases of UGTB patients were analyzed retrospectively. We considered age, gender, symptoms, and diagnostic procedures. Read More

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http://dx.doi.org/10.1007/s00345-019-02767-xDOI Listing

[Laboratory tests for kidney disease].

Authors:
G M Fiedler B Vogt

Internist (Berl) 2019 Apr 17. Epub 2019 Apr 17.

Universitätsklinik für Nephrologie und Hypertonie, Inselspital, Universitätsspital Bern, Universität Bern, 3010, Bern, Schweiz.

Kidney diseases are among the most frequently reported diseases with a poor prognosis that are diagnosed too late. According to current Kidney Disease Improving Global Outcomes (KDIGO) guidelines, diagnosis and risk stratification are mainly based on functional markers (creatinine and cystatin C), which are used to determine the estimated glomerular filtration rate (eGFR) and the analysis of urinary albumin excretion as a marker of kidney damage. These methods have limitations that can complicate the interpretation of the results and can lead to a delay of the diagnosis as well as to a misinterpretation of the prognosis. Read More

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http://dx.doi.org/10.1007/s00108-019-0598-3DOI Listing

Increased body fatness adversely relates to 24-hour urine pH during childhood and adolescence: evidence of an adipo-renal axis.

Am J Clin Nutr 2019 Apr 17. Epub 2019 Apr 17.

DONALD Study Center, Department of Nutritional Epidemiology, Institute of Nutrition and Food Science, University of Bonn, Dortmund, Germany.

Background: Reduced net acid excretion (NAE) capacity indicates a decrease in renal function. This reduction manifests as a disproportionally low 24-h urine pH in relation to the sum of actually excreted ammonium and titratable acidity by the kidney.

Objective: The aim of this study was to test the hypothesis that higher body fatness is one determinant of kidney function impairment with a lowered urine pH even at a young age. Read More

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http://dx.doi.org/10.1093/ajcn/nqy379DOI Listing

Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies.

Kidney Int Rep 2019 Apr 21;4(4):541-550. Epub 2018 Dec 21.

Department of Pediatrics, Division of Pediatric Nephrology, Duke University, Durham, North Carolina, USA.

Introduction: Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non-human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific antibodies (DSAs). Our aim was to examine serum cytokine profiles associated with AT1R-Ab and distinguish them from those associated with HLA DSA in serially collected blood samples from a cohort of pediatric renal transplant recipients.

Methods: Blood samples from 65 pediatric renal transplant recipients drawn during the first 3 months posttransplant, at 6, 12, and 24 months posttransplant, and during suspected episodes of kidney transplant rejection were tested for AT1R-Ab, HLA DSA, and a panel of 6 cytokines (tumor necrosis factor [TNF]-α, interferon [IFN]-γ, interleukin [IL]-8, IL-1β, IL-6, and IL-17). Read More

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http://dx.doi.org/10.1016/j.ekir.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451195PMC

Establishment of a monoclonal antibody PMab-225 against alpaca podoplanin for immunohistochemical analyses.

Biochem Biophys Rep 2019 Jul 5;18:100633. Epub 2019 Apr 5.

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Podoplanin (PDPN) is known as a lymphatic endothelial cell marker. Monoclonal antibodies (mAbs) against human, mouse, rat, rabbit, dog, cat, bovine, pig, and horse PDPN have been established in our previous studies. However, mAbs against alpaca PDPN (aPDPN), required for immunohistochemical analysis, remain to be developed. Read More

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http://dx.doi.org/10.1016/j.bbrep.2019.100633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451175PMC

Introducing an AKI predictive tool for patients undergoing orthopaedic surgery.

BMJ Open Qual 2019 29;8(1):e000306. Epub 2019 Mar 29.

Renal Medicine, Ninewells Hospital, Dundee, UK.

Patients undergoing surgery are at increased risk of acute kidney injury (AKI). AKI is associated with adverse outcomes such as increased mortality and future risk of developing chronic kidney disease. We have developed a validated preoperative scoring tool to predict postoperative AKI in patients undergoing orthopaedic surgery using seven readily available parameters. Read More

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http://qir.bmj.com/lookup/doi/10.1136/bmjoq-2017-000306
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http://dx.doi.org/10.1136/bmjoq-2017-000306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440603PMC
March 2019
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Calcium isotope ratios in blood and urine: A new biomarker for the diagnosis of osteoporosis.

Bone Rep 2019 Jun 16;10:100200. Epub 2019 Mar 16.

Clinical Research Center Kiel GmbH, Schauenburgerstraße 116, 24118 Kiel, Germany.

We assessed the potential of Calcium (Ca) isotope fractionation measurements in blood (δCa) and urine (δCa) as a new biomarker for the diagnosis of osteoporosis. One hundred post-menopausal women aged 50 to 75 years underwent dual-energy X-ray absorptiometry (DXA), the gold standard for determination of bone mineral density. After exclusion of women with kidney failure and vitamin D deficiency (<25 nmol/l) 80 women remained in the study. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453776PMC

Clinical Conundrums in the Management of Diabetic Ketoacidosis in the Elderly.

J Transl Int Med 2019 Mar 29;7(1):10-14. Epub 2019 Mar 29.

St. Vincent Hospital Indianapolis, IN, Indianapolis, USA.

One of the dreaded life-threatening complications of diabetes mellitus (DM) is diabetic ketoacidosis (DKA). American Diabetic Association (ADA) came out with 2018 guidelines on the management of DM and its complications, but these are woefully silent on the clinical conundrums that accompany DKA in elderly patients. In elderly patients, DKA is often complicated by sepsis, atrial fibrillation, polypharmacy, nonketotic hyperosmolar states, atypical clinical presentations, acute kidney injury (AKI), dementia, and noncompliance with medications. Read More

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http://content.sciendo.com/view/journals/jtim/7/1/article-p1
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http://dx.doi.org/10.2478/jtim-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463825PMC
March 2019
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Comparison of long-term kidney functions after radical nephrectomy and simple nephrectomy.

PeerJ 2019 12;7:e6701. Epub 2019 Apr 12.

Clinic of Urology, University of Health Sciences, Sultan Abdulhamit Han Training and Research Hospital, Istanbul, Turkey.

Objective: To determine if there is a difference in proceeding to CKD between patients who had undergone radical nephrectomy (RN) and simple nephrectomy (SN) for different indications by comparing the short- and long-term renal function.

Materials And Methods: We retrospectively analyzed the records of all patients who underwent nephrectomy (either for malign or benign indications) in our clinic between January 2007 and September 2017. The patients were divided into 2 groups according the type of surgery: 1) Radical nephrectomy Group, 2) Simple Nephrectomy Group. Read More

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http://dx.doi.org/10.7717/peerj.6701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463866PMC

Reporting quality of pilot clinical trials in chronic kidney disease patients on hemodialysis: a methodological survey.

Pilot Feasibility Stud 2019 6;5:53. Epub 2019 Apr 6.

3Department of Health Research, Evidence, and Impact, McMaster University, Hamilton, Ontario Canada.

Background: The conduct of high-quality pilot studies can help inform the success of larger clinical trials. Guidelines have been recently developed for the reporting of pilot trials.

Objective: This methodological survey evaluates the completeness of reporting in pilot randomized controlled trials in chronic kidney disease patients on hemodialysis (HD patients) and explores factors associated with better completion of reporting. Read More

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http://dx.doi.org/10.1186/s40814-019-0436-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451784PMC

Prevalence of early stages of heart failure in an elderly risk population: the Copenhagen Heart Failure Risk Study.

Open Heart 2019 27;6(1):e000840. Epub 2019 Feb 27.

Department of Cardiology, Herlev and Gentofte University Hospital, Herlev, Denmark.

Aims: To describe the prevalence of heart failure (HF) stages in elderly outpatients with risk factors for HF but without known HF, and characterise the clinical, biochemical and echocardiographic findings in each stage.

Background: Early stages of HF are underdiagnosed; nevertheless, they are associated with an increased risk of hospitalisation and increased mortality. The prevalence of HF stages in elderly high-risk patients is unknown. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443139PMC
February 2019

A misdiagnosed cause of early postoperative bowel obstruction.

Clin Case Rep 2019 Apr 17;7(4):832-833. Epub 2019 Feb 17.

Department of General Surgery General Hospital of Drama Drama Greece.

In the setting of altered anatomy, diagnosis of superior mesenteric artery syndrome requires high clinical and imaging suspicion as the defined imaging criteria cannot be applied. Read More

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http://dx.doi.org/10.1002/ccr3.2052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452497PMC

Acute non-heparin-induced thrombocytopenia during hemodiafiltration in a patient with multiple myeloma.

Clin Case Rep 2019 Apr 22;7(4):699-702. Epub 2019 Feb 22.

Department of Clinical Laboratory Kyoto University Hospital Kyoto Japan.

This report demonstrates that not only heparin-induced thrombocytopenia, but also hemodialysis conditions (platelet activation due to hemodiafiltration and heparin underdosing) may markedly reduce the platelet count and cause clotting in the hemodialysis circuit in patients in a hypercoagulable state. The clot prevention effects of bortezomib are therefore of great importance. Read More

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http://dx.doi.org/10.1002/ccr3.1997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452500PMC

Refractory exudative pleural effusion in patients with chronic kidney disease not receiving dialysis: A case report.

Clin Case Rep 2019 Apr 19;7(4):675-679. Epub 2019 Feb 19.

Division of Nephrology, Department of Internal Medicine, School of Medicine, Jeju National University Hospital Jeju National University Jeju City Korea.

Although exudative pleural effusion can be caused by infections, malignancies, and connective tissue diseases, we need to consider uremic pleural effusion and pleuritis in differential diagnosis of exudative lymphocyte predominant pleural effusion in patients with chronic kidney disease not receiving dialysis. Read More

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http://dx.doi.org/10.1002/ccr3.2069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452446PMC

Effects of hydroxyapatite@poly-lactide--glycolide nanoparticles combined with Pb and Cd on liver and kidney parenchyma after the reconstruction of mandibular bone defects.

Toxicol Res (Camb) 2019 Mar 5;8(2):287-296. Epub 2019 Feb 5.

Institute of Technical Sciences , Serbian Academy of Science and Arts , Knez Mihailova 35/IV , P.O. Box 377 , 11000 Belgrade , Serbia . Email: ; Email:

Reconstruction of bone defects with the use of biomaterials based on hydroxyapatite (HAp) has been a popular approach in medicine and dentistry. Most often the process of new bone formation is analyzed with the focus only on the region of the reconstructed defect. The effects of the therapy on distant organs have been rarely reported in the literature, especially not in synergy with the exposure to other bioactive chemicals. Read More

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http://dx.doi.org/10.1039/c9tx00007kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430097PMC

Chronic low-level cadmium exposure in rats affects cytokine production by activated T cells.

Toxicol Res (Camb) 2019 Mar 4;8(2):227-237. Epub 2019 Jan 4.

Department of Pharmacology & Toxicology , Michigan State University , East Lansing , MI 48824 , USA . Email: ; Tel: +517-884-6692.

Cadmium is a toxic metal and common environmental contaminant. Chronic cadmium exposure results in kidney, bone, reproductive, and immune toxicity as well as cancer. Cadmium induces splenomegaly and affects the adaptive immune system, but specific effects vary depending on the dose, model, and endpoint. Read More

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http://dx.doi.org/10.1039/c8tx00194dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425995PMC

Endovascular intervention for iliac vein thrombosis after simultaneous kidney-pancreas transplant.

J Surg Case Rep 2019 Apr 10;2019(4):rjz024. Epub 2019 Apr 10.

Temple Heart and Vascular Institute, Temple University Hospital, 3509 N. Broad Street, Boyer Pavilion 4th Floor, Philadelphia, PA 19140, USA.

May-Thurner syndrome (MTS) is an anatomic variant where the overlying right common iliac artery compresses and chronically obstructs the left common iliac vein, leading to thrombosis. Interventions for symptomatic MTS include endovascular thrombectomy and stenting. Occluding venous thrombus can be fatal to transplanted allografts. Read More

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http://dx.doi.org/10.1093/jscr/rjz024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457065PMC
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