375 results match your criteria Keratosis Pilaris


Cutaneous adverse events in children treated with vemurafenib for refractory BRAF mutated Langerhans cell histiocytosis.

Pediatr Blood Cancer 2021 Jun 9:e29140. Epub 2021 Jun 9.

French Reference Center for Langerhans Cell Histiocytosis, Trousseau Hospital, Paris, France.

Background: The somatic BRAF mutation occurs in 38-64% of pediatric cases of Langerhans cell histiocytosis (LCH). Vemurafenib (VMF), a BRAF inhibitor, was approved for refractory BRAF mutated LCH. In adults, VMF causes frequent cutaneous adverse events (CAE) including skin tumors (squamous cell carcinomas, melanomas), but little is known in children. Read More

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Impaired glucose-1,6-biphosphate production due to bi-allelic PGM2L1 mutations is associated with a neurodevelopmental disorder.

Am J Hum Genet 2021 06 11;108(6):1151-1160. Epub 2021 May 11.

de Duve Institute, UCLouvain, 1200 Brussels, Belgium. Electronic address:

We describe a genetic syndrome due to PGM2L1 deficiency. PGM2 and PGM2L1 make hexose-bisphosphates, like glucose-1,6-bisphosphate, which are indispensable cofactors for sugar phosphomutases. These enzymes form the hexose-1-phosphates crucial for NDP-sugars synthesis and ensuing glycosylation reactions. Read More

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Cutaneous Manifestations of Nutritional Excess: Pathophysiologic Effects of Hyperglycemia and Hyperinsulinemia on the Skin.

Cutis 2021 Feb;107(2):74-78

Mr. Svoboda is from the Virginia Tech Carilion School of Medicine, Roanoke. Dr. Shields is from the Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison.

Hyperglycemia is defined by excess blood glucose and, when persistent, may lead to prediabetic and diabetic states. Insulin is a hormone produced by the beta cells of the pancreas in response to elevated blood glucose. Dysregulated insulin secretion or clearance results in hyperinsulinemia, which also is closely associated with type 2 diabetes mellitus (T2DM) and metabolic disturbances. Read More

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February 2021

Dermoscopy of Anserine Folliculosis.

Dermatol Pract Concept 2021 Mar 8;11(2):e2021019. Epub 2021 Mar 8.

Department of Dermatology, Kasturba Medical College, MAHE, Manipal, India.

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Spiky/keratosis-pilaris-like early follicular mycosis fungoides: A clinicopathologic study of 20 cases with extended follow-up.

J Cutan Pathol 2021 Mar 6. Epub 2021 Mar 6.

Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy.

Backgrounds: Follicular mycosis fungoides (FMFs) is a distinct form of T-cell lymphoma whose course is considered aggressive.

Methods: A retrospective study with long-term follow-up of 20 patients diagnosed with spiky/keratosis-pilaris-like FMF between 2008 and 2017 was conducted.

Results: Twelve males and eight females were identified, with a mean age at first diagnosis of 59 years (range 42-86). Read More

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Systemic isotretinoin treatment in a renal transplant patient developing sebaceous hyperplasia due to cyclosporine.

North Clin Istanb 2020 22;7(6):628-630. Epub 2020 Jul 22.

Department of Dermatology, Haseki Training and Research Hospital, Istanbul, Turkey.

Sebaceous hyperplasia (SH) is a benign tumor with telangiectasia on it, yellowish or skin-colored, with papulosis. Besides genetic factors, aging, ultraviolet rays, sex hormones, calcineurin inhibitors, such as cyclosporin, tacrolimus and systemic steroids, play a role in the development of sebaceous hyperplasia. Cyclosporin is widely used in organ transplant patients. Read More

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Keratosis pilaris with adjacent haemosiderin deposition: a clue to scurvy.

Pathology 2020 Dec 11. Epub 2020 Dec 11.

Pathology Queensland, Princess Alexandra Hospital Laboratory, Woolloongabba, QLD, Australia.

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December 2020

Skin manifestations after bariatric surgery.

BMC Dermatol 2020 12 9;20(1):21. Epub 2020 Dec 9.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Skin and Allergy Research Unit, Chulalongkorn University, 1873 Rama IV Road, Pathumwan, Bangkok, 10330, Thailand.

Background: Skin signs observed in morbid obesity may change as the weight reduces, especially post-bariatric surgery (BaS). Data concerning the skin findings exclusively in post-BaS patients remain limited.

Methods: Seventy post-BaS patients were examined for cutaneous abnormalities. Read More

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December 2020

Nilotinib-induced keratosis pilaris associated with cicatricial alopecia resembling frontal fibrosing alopecia.

Dermatol Ther 2021 01 3;34(1):e14579. Epub 2020 Dec 3.

Department of Dermatology, University of Tunis, Military Hospital of Instruction of Tunis, Tunis, Tunisia.

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January 2021

Co-existent Erythromelanosis Follicularis Faciei Colli and Erythroses Pigmentosa Mediofacialis in a Patient of Generalized Keratosis Pilaris - A Rare Report in a Young Female.

Indian Dermatol Online J 2020 Sep-Oct;11(5):818-822. Epub 2020 Sep 19.

Department of Dermato-Venereo-Leprology, Government Medical College and Hospital, Nagpur, Maharashtra, India.

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September 2020

"Extraction Dermoscopy": Expanding the Utility of Epiluminescence Microscopy.

Skin Appendage Disord 2020 Jul 25;6(4):220-223. Epub 2020 Jun 25.

Department of Dermatology, LTMMC and LTMGH, Sion West, Mumbai, India.

Introduction: Many dermatological conditions require extraction of material from the lesion followed by visualization under a microscope. However, visualization of the extracted material can be done using a dermoscope instead. We propose "extraction dermoscopy" as an addition to the already existing treasury that dermoscopy holds. Read More

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Follicular psoriasis: a report of 5 cases and review of the literature, likely an under-recognized yet distinctive variant of psoriasis.

Dermatol Online J 2020 Jul 15;26(7). Epub 2020 Jul 15.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.

Psoriasis is a common autoimmune dermatosis representing an interplay between certain genetic predisposing factors along with clonally restricted Th1 T cells responding to epidermal keratinocyte derived antigen. A unique IL17/IL23 cytokine-rich milieu is pathogenetically significant and conducive to its salient histomorphologic features, such as epidermal hyperplasia and intraepidermal influx of neutrophils. The classic cutaneous manifestation is that of plaque psoriasis also referred to as psoriasis vulgaris with characteristic well-circumscribed erythematous plaques covered by silvery scales. Read More

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Treatment of keratosis pilaris and its variants: a systematic review.

J Dermatolog Treat 2020 Sep 14:1-12. Epub 2020 Sep 14.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Introduction: Keratosis pilaris (KP) is a common, benign skin condition of follicular hyperkeratosis. Although KP is asymptomatic, the cosmetic appearance of KP can lead to psychosocial distress among patients. New emerging treatments are increasingly being utilized. Read More

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September 2020

Light and Laser Treatments for Keratosis Pilaris: A Systematic Review.

Dermatol Surg 2020 11;46(11):1397-1402

Department of Dermatology, Hotel Dieu de France University Hospital, Beirut, Lebanon.

Background: Keratosis pilaris (KP) is a common hereditary keratinization disorder. Keratosis pilaris rubra and KP atrophicans faciei are less frequent variants of the disease. Topical treatments often yield ineffective and temporary results. Read More

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November 2020

Costello syndrome model mice with a Hras mutation are susceptible to develop house dust mite-induced atopic dermatitis.

Cell Death Dis 2020 08 13;11(8):617. Epub 2020 Aug 13.

Department of Medical Genetics, Tohoku University Graduate School of Medicine, Sendai, Japan.

Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations. Patients with Costello syndrome present craniofacial abnormalities, cardiac defects, and cancer predisposition, as well as skin abnormalities, including papillomas, keratosis pilaris, and eczematous dermatitis. However, the mechanisms underlying the dermatological abnormalities remain unclear. Read More

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The versatility of azelaic acid in dermatology.

J Dermatolog Treat 2020 Aug 4:1-11. Epub 2020 Aug 4.

Department of Dermatology, Aalborg University Hospital, Aalborg, Denmark.

Azelaic acid has numerous pharmacological uses in dermatology. Its anti-inflammatory and anti-oxidant properties are thought to correlate with its efficacy in papulopustular rosacea and acne vulgaris, amongst other cutaneous conditions. We conducted a review of the literature on the use of azelaic acid in dermatology using key terms 'acne', 'azelaic acid', 'dermatology', 'melasma', 'rosacea', searching databases such as MEDLINE, EMBASE and PubMed. Read More

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Āyuṛveda management of keratosis pilaris - a case report.

J Complement Integr Med 2020 Jul 21;18(1):223-230. Epub 2020 Jul 21.

Department of Panchakarma, Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidhyapeetham, Kollam, India.

Objectives: Keratosis pilaris (KP) is the condition of the skin with extensive keratin follicular plugging. It may be associated with the erythema. The upper arm extensor area, shoulders, back of neck and thighs, as well as face and the upper trunk are the areas of presentation. Read More

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Cutaneous reactions in children treated with MEK inhibitors, BRAF inhibitors, or combination therapy: A multicenter study.

J Am Acad Dermatol 2021 Jun 17;84(6):1554-1561. Epub 2020 Jul 17.

Division of Pediatric Medicine Section of Dermatology, University of Toronto, Toronto, Canada.

Background: Treatment with BRAF inhibitors (BRAFI) and MEK inhibitors (MEKI) causes cutaneous reactions in children, limiting dosing or resulting in treatment cessation. The spectrum and severity of these reactions is not defined.

Objective: To determine the frequency and spectrum of cutaneous reactions in children receiving BRAFI and MEKI and their effects on continued therapy. Read More

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Seasonal variability in public searches of keratosis pilaris: How the internet can illuminate a pattern in public interest.

Dermatol Ther 2020 11 25;33(6):e13957. Epub 2020 Jul 25.

School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

In this study, we examine keratosis pilaris search patterns using Google Trends to determine any seasonality. Monthly searches were collected from January 2004 to January 2020 using "keratosis pilaris" as the search term in the Google Trends database. The US search data were compared to monthly temperatures and tested for correlation. Read More

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November 2020

Keratosis pilaris-like eruption secondary to nilotinib in a child.

Pediatr Dermatol 2020 Sep 29;37(5):968-969. Epub 2020 Jun 29.

Department of Dermatology, University Hospital La Paz, Madrid, Spain.

Nilotinib is a new multitargeted tyrosine kinase inhibitor, which is used to treat chronic myelogenous leukemia when intolerance or recurrence to imatinib occurs. We report the case of a 14-year-old patient being treated with nilotinib who developed a keratosis pilaris-like eruption. This cutaneous adverse effect is a rare but increasingly reported side effect of this therapy. Read More

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September 2020

Assessment of 5-Aminolaevulinic Acid Photodynamic Therapy (ALA-PDT) in Chinese patients with actinic keratosis: Correlation of dermoscopic features with histopathology.

Australas J Dermatol 2020 Aug 18;61(3):e339-e343. Epub 2020 May 18.

Department of Dermatology, Peking University Third Hospital, Beijing, China.

Objectives: The study examines the changes in dermoscopic features of actinic keratosis (AK) after photodynamic therapy, and delineates the association between AK dermoscopic and histopathological findings.

Methods: A total of 21 patients (23 lesions) with pathologically confirmed actinic keratosis who received 5-aminolaevulinic acid (ALA) photodynamic therapy (ALA-PDT) were enrolled. The numbers of PDT treatments were: 1, n = 1; 2, n = 2; 3, n = 10; 4, n = 6; 5, n = 2; 6, n = 2). Read More

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Two is better than one: The combined effects of glycolic acid and salicylic acid on acne-related disorders.

J Cosmet Dermatol 2020 Sep 6;19(9):2349-2351. Epub 2020 Apr 6.

William Beaumont Hospital-Royal Oak, Royal Oak, MI.

Background: Many companies capitalized on treatable skin conditions by providing expensive prescription medications or high-end over-the-counter cosmetics. However, patients have become more apprehensive toward these medications in lieu of their often-detrimental side effect profile and reactivity with sensitive skin.

Aims: We developed a serum was created to counteract this budding problem. Read More

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September 2020

Skin and nails abnormalities in a patient with ZTTK syndrome and a de novo mutation in SON.

Pediatr Dermatol 2020 May 11;37(3):517-519. Epub 2020 Feb 11.

Department of Dermatology, Hospital Universitario La Paz, Madrid, Spain.

Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome is a rare, severe, and recently described multisystem developmental disorder characterized by delayed psychomotor development and intellectual disability, characteristic facial features, hypotonia, poor overall growth, and visual abnormalities. Mucocutaneous manifestations have not been reported so far among individuals with ZTTK syndrome. Herein, we present a patient with ZTTK syndrome due to a de novo mutation in SON gene, who has dental abnormalities and retronychia of the toenails. Read More

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Intense Pulsed-light Therapy Significantly Improves Keratosis Pilaris: A Randomized, Double-blind, Sham Irradiation-controlled Trial.

J Clin Aesthet Dermatol 2019 Oct 1;12(10):E53-E57. Epub 2019 Oct 1.

Drs. Maitriwong, Tangkijngamvong, and Asawanonda are with Division of Dermatology in the Department of Medicine, Faculty of Medicine at the Chulalongkorn University in Bangkok, Thailand.

Keratosis pilaris (KP) is a common benign follicular disorder for which various topical and laser treatments have been used, with limited efficacy. We evaluated the efficacy of intense pulsed light (IPL) therapy for the reduction of skin roughness, erythema, and hyperpigmentation in Thai subjects with KP. Twenty-four Thai patients with untreated KP on the upper outer arms were enrolled in a randomized, double-blind study. Read More

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October 2019

Hyperkeratotic Skin Adverse Events Induced by Anticancer Treatments: A Comprehensive Review.

Drug Saf 2020 05;43(5):395-408

Oncodermatology, Institut Claudius REGAUD and Institut Universitaire du Cancer Toulouse Oncopole, 1 avenue Irène Joliot-Curie 31059, Toulouse Cedex 9, France.

Hyperkeratotic skin adverse events are a group of toxic effects, characterized by the disruption of epidermal homeostasis and interaction with keratinocyte proliferation/differentiation or keratinocyte survival, and frequently reported with systemic anticancer treatments. These types of reactions include hand-foot skin reaction or palmoplantar keratoderma, induced psoriasis, keratosis pilaris-like or pityriasis rubra pilaris-like rashes, Grover's disease, and contact hyperkeratosis. Cutaneous squamoproliferative lesions are also described because of the presence of abnormal keratinocyte proliferation. Read More

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"Comparative study between the efficacy of fractional CO2 laser, Q-switched Nd:YAG laser (1064 nm), and both types in treatment of keratosis pilaris".

Lasers Med Sci 2020 Aug 11;35(6):1367-1376. Epub 2020 Jan 11.

Kasr El Aini Cairo University Hospital, Cairo, Egypt.

The aim of this study was to assess and compare the efficacy of fractional CO2 laser, Q-switched Nd:YAG laser (1064 nm), and their combined use in treatment of keratosis pilaris. The study included twenty female patients. For each patient, three areas were randomly assigned to treatment by either fractional CO2 laser (area A) or Q-switched laser (1064 nm) (area C), or both types of laser (area B). Read More

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Diabetic Skin Changes Can Benefit from Moisturizer and Cleanser Use: A Review

J Drugs Dermatol 2019 Dec;18(12):1211-1217

INTRODUCTION: Diabetes mellitus (DM) associated skin changes, which may be the first sign of DM in undiagnosed patients. Frequently these patients present with dry skin, which may benefit from the use of gentle cleansers and moisturizers. A review paper was developed to explore DM-associated skin changes and possible benefits of cleanser and moisturizer use. Read More

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December 2019

The different faces of mycosis fungoides: results of a single-center study.

Int J Dermatol 2020 Mar 29;59(3):314-320. Epub 2019 Nov 29.

1st Department of Dermatology-Venereology, Faculty of Medicine, National and Kapodistrian University of Athens, Cutaneous Lymphoma Clinic, "A. Sygros" Hospital for Skin & Venereal Diseases, Athens, Greece.

Background: Mycosis fungoides (MF) accounts for the majority of cutaneous lymphomas. Apart from the predominant Alibert-Bazin type, several clinicopathological variants of diverse prevalence and biological behavior have been described. Data on clinical and epidemiological aspects of MF clinical subtypes are still weak. Read More

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Queratosis Pilaris.

Authors:

Pediatr Dermatol 2019 Nov;36(6):e106-e107

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November 2019

Keratosis Pilaris.

Authors:

Pediatr Dermatol 2019 Nov;36(6):937-938

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November 2019