Search Our Scientific Publications & Authors

Dermatol Ther 2020 Jul 4:e13957. Epub 2020 Jul 4.

School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

In this study, we examine keratosis pilaris search patterns using Google Trends to determine any seasonality. Monthly searches were collected from January 2004 to January 2020 using "keratosis pilaris" as the search term in the Google Trends database. United States search data was compared to monthly temperatures and tested for correlation. Read More

Pediatr Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, University Hospital La Paz, Madrid, Spain.

Nilotinib is a new multitargeted tyrosine kinase inhibitor, which is used to treat chronic myelogenous leukemia when intolerance or recurrence to imatinib occurs. We report the case of a 14-year-old patient being treated with nilotinib who developed a keratosis pilaris-like eruption. This cutaneous adverse effect is a rare but increasingly reported side effect of this therapy. Read More

Australas J Dermatol 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Peking University Third Hospital, Beijing, China.

Objectives: The study examines the changes in dermoscopic features of actinic keratosis (AK) after photodynamic therapy, and delineates the association between AK dermoscopic and histopathological findings.

Methods: A total of 21 patients (23 lesions) with pathologically confirmed actinic keratosis who received 5-aminolaevulinic acid (ALA) photodynamic therapy (ALA-PDT) were enrolled. The numbers of PDT treatments were: 1, n = 1; 2, n = 2; 3, n = 10; 4, n = 6; 5, n = 2; 6, n = 2). Read More

J Cosmet Dermatol 2020 Apr 6. Epub 2020 Apr 6.

William Beaumont Hospital-Royal Oak, Royal Oak, MI.

Background: Many companies capitalized on treatable skin conditions by providing expensive prescription medications or high-end over-the-counter cosmetics. However, patients have become more apprehensive toward these medications in lieu of their often-detrimental side effect profile and reactivity with sensitive skin.

Aims: We developed a serum was created to counteract this budding problem. Read More

Pediatr Dermatol 2020 May 11;37(3):517-519. Epub 2020 Feb 11.

Department of Dermatology, Hospital Universitario La Paz, Madrid, Spain.

Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome is a rare, severe, and recently described multisystem developmental disorder characterized by delayed psychomotor development and intellectual disability, characteristic facial features, hypotonia, poor overall growth, and visual abnormalities. Mucocutaneous manifestations have not been reported so far among individuals with ZTTK syndrome. Herein, we present a patient with ZTTK syndrome due to a de novo mutation in SON gene, who has dental abnormalities and retronychia of the toenails. Read More

J Clin Aesthet Dermatol 2019 Oct 1;12(10):E53-E57. Epub 2019 Oct 1.

Drs. Maitriwong, Tangkijngamvong, and Asawanonda are with Division of Dermatology in the Department of Medicine, Faculty of Medicine at the Chulalongkorn University in Bangkok, Thailand.

Keratosis pilaris (KP) is a common benign follicular disorder for which various topical and laser treatments have been used, with limited efficacy. We evaluated the efficacy of intense pulsed light (IPL) therapy for the reduction of skin roughness, erythema, and hyperpigmentation in Thai subjects with KP. Twenty-four Thai patients with untreated KP on the upper outer arms were enrolled in a randomized, double-blind study. Read More

Drug Saf 2020 May;43(5):395-408

Oncodermatology, Institut Claudius REGAUD and Institut Universitaire du Cancer Toulouse Oncopole, 1 avenue Irène Joliot-Curie 31059, Toulouse Cedex 9, France.

Hyperkeratotic skin adverse events are a group of toxic effects, characterized by the disruption of epidermal homeostasis and interaction with keratinocyte proliferation/differentiation or keratinocyte survival, and frequently reported with systemic anticancer treatments. These types of reactions include hand-foot skin reaction or palmoplantar keratoderma, induced psoriasis, keratosis pilaris-like or pityriasis rubra pilaris-like rashes, Grover's disease, and contact hyperkeratosis. Cutaneous squamoproliferative lesions are also described because of the presence of abnormal keratinocyte proliferation. Read More

Lasers Med Sci 2020 Jan 11. Epub 2020 Jan 11.

Kasr El Aini Cairo University Hospital, Cairo, Egypt.

The aim of this study was to assess and compare the efficacy of fractional CO2 laser, Q-switched Nd:YAG laser (1064 nm), and their combined use in treatment of keratosis pilaris. The study included twenty female patients. For each patient, three areas were randomly assigned to treatment by either fractional CO2 laser (area A) or Q-switched laser (1064 nm) (area C), or both types of laser (area B). Read More

J Drugs Dermatol 2019 Dec;18(12):1211-1217

INTRODUCTION: Diabetes mellitus (DM) associated skin changes, which may be the first sign of DM in undiagnosed patients. Frequently these patients present with dry skin, which may benefit from the use of gentle cleansers and moisturizers. A review paper was developed to explore DM-associated skin changes and possible benefits of cleanser and moisturizer use. Read More

Int J Dermatol 2020 Mar 29;59(3):314-320. Epub 2019 Nov 29.

1st Department of Dermatology-Venereology, Faculty of Medicine, National and Kapodistrian University of Athens, Cutaneous Lymphoma Clinic, "A. Sygros" Hospital for Skin & Venereal Diseases, Athens, Greece.

Background: Mycosis fungoides (MF) accounts for the majority of cutaneous lymphomas. Apart from the predominant Alibert-Bazin type, several clinicopathological variants of diverse prevalence and biological behavior have been described. Data on clinical and epidemiological aspects of MF clinical subtypes are still weak. Read More

Pediatr Dermatol 2019 Nov;36(6):937-938

Lasers Surg Med 2020 Jul 11;52(6):509-514. Epub 2019 Nov 11.

Department of Medicine, Division of Dermatology, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Road, Bangkok, 10330, Thailand.

Background And Objective: Keratosis pilaris (KP) is a common follicular disorder for which various topical agents and energy-based devices have been used with some efficacy. To evaluate the efficacy of a novel 1064-nm Nd:YAG laser for the reduction of skin roughness, erythema, and hyperpigmentation in KP subjects.

Study Design/materials And Methods: Twenty-three subjects with untreated KP on the upper outer arms participated in a randomized, single-blind fashion. Read More

Pan Afr Med J 2019 30;33:274. Epub 2019 Jul 30.

Hôpital Civil Tétouan, Tétouan, Maroc.

Keratosis pilaris is characterized by small bumps around hair follicles. Keratosis pilaris simplex results in gray and keratotic papules mainly on the arms, thighs and buttocks. It mainly affects women. Read More

Drug Discov Ther 2019 Nov 27;13(5):294-296. Epub 2019 Oct 27.

Department of Tropical Medicine, School of Tropical Medicine, Kolkata, West Bengal, India.

Graham Little Piccardi Lassueur syndrome (GLPLS) is a rare dermatosis characterized by patchy cicatricial alopecia of scalp, rapidly developing keratosis pilaris like follicular papules over trunk and extremities, and noncicatricial loss of axillary and pubic hair. This syndrome which is mostly seen in middle aged post-menopausal females (between ages 30-70)has rarely ever been described in the pediatric age group. We report a case of a 15 year old girl presenting to us with this rare syndrome. Read More

Pediatr Dermatol 2020 Jan 18;37(1):219-221. Epub 2019 Oct 18.

Department of Dermatology, Baylor College of Medicine, Houston, TX, USA.

Disorders involving follicular occlusion, such as hidradenitis suppurativa, folliculitis, acneiform eruptions, and pilonidal cysts, have shown an increased prevalence in the Down syndrome (DS) population, but there are limited published data examining this association. We conducted a retrospective chart review of 243 DS patients presenting to a pediatric dermatology clinic to further examine the prevalence of disorders of follicular occlusion in DS patients. Our study showed high rates of disorders of follicular occlusion in DS patients, with prevalent disorders including folliculitis (21. Read More

J Am Acad Dermatol 2019 Nov;81(5):1037-1057

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida; Veterans Affairs Miami Health Care System, Miami, Florida. Electronic address:

Obesity is a worldwide major public health problem with an alarmingly increasing prevalence over the past 2 decades. The consequences of obesity in the skin are underestimated. In this paper, we review the effect of obesity on the skin, including how increased body mass index affects skin physiology, skin barrier, collagen structure, and wound healing. Read More

Indian Dermatol Online J 2019 Sep-Oct;10(5):613-614. Epub 2019 Aug 28.

Department of Dermatology, Poornima Hospital, HMT Layout, RT Nagar, Bengaluru, Karnataka, India.

J Cosmet Dermatol 2020 May 16;19(5):1110-1120. Epub 2019 Sep 16.

Department of Dermatology, Venereology & Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: Numerous treatment modalities for keratosis pilaris have been tried with limited success.

Aim: To determine the efficacy, safety, and tolerability of fractional CO2 laser in the treatment of KP.

Patients And Methods: This prospective, single-blinded split-body placebo-controlled comparative study was conducted on 60 patients with bilateral KP of arms (group A) and thighs (group B). Read More

Cureus 2019 Jun 22;11(6):e4970. Epub 2019 Jun 22.

Dermatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, USA.

Hidradenitis suppurativa (HS) is an inflammatory disorder characterized by recurrent painful nodules and draining sinus tracts with subsequent scarring. HS has been associated with several dermatologic syndromes including the follicular occlusion tetrad, PASH (pyoderma gangrenosum, acne, and suppurativa hidradenitis), PAPASH (pyogenic arthritis, pyoderma gangrenosum, acne, and suppurativa hidradenitis), and SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndromes. However, aside from the well-established association between HS and Down Syndrome, it has rarely been reported in association with other multisystem genetic diseases. Read More

J Cosmet Dermatol 2020 Apr 24;19(4):960-963. Epub 2019 Aug 24.

Department of Dermatology, Allergology and Venereology, Helsinki University Central Hospital, Helsinki, Finland.

The search for clinical signs suggestive of diseases and medical analysis in works of art and portraits is also known as iconodiagnosis. It raises discussions about underlying diseases and about whether the artist intended to represent them. We assessed the frequency of cutaneous signs in paintings on display in the permanent collections of the Ateneum and Sinebrychoff Art Museums, Finnish National Gallery in Helsinki. Read More

J Dtsch Dermatol Ges 2019 Jul;17(7):748-751

Department of Dermatology, Hospital Universitario de Cabueñes, Gijón, Spain.

J Allergy Clin Immunol Pract 2020 Jan 25;8(1):102-112. Epub 2019 Jul 25.

Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Fla.

Allergists/immunologists see a variety of skin disorders, some of which have a known immunologic basis whereas others do not. We review the prevalence, etiology, clinical presentation, and effective and low-cost care of common dermatologic conditions seen in outpatient practices. Conditions discussed include pityriasis alba, seborrheic dermatitis, rosacea, acne, tinea infections, intertrigo, lichen planus, tinea versicolor, lichen simplex chronicus, scabies, pityriasis rosea, keratosis pilaris, and seborrheic keratosis. Read More

G Ital Dermatol Venereol 2019 Jul 12. Epub 2019 Jul 12.

Dermatology Department, Ramon y Cajal University Hospital, Madrid, Spain.

J Dtsch Dermatol Ges 2019 Jul 18;17(7):749-751. Epub 2019 Jun 18.

Department of Dermatology, Hospital Universitario de Cabueñes, Gijón, Spain.

JAAD Case Rep 2019 Apr 5;5(4):352-354. Epub 2019 Apr 5.

Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah.

Int J Dermatol 2019 Aug 9;58(8):e151-e152. Epub 2019 Apr 9.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

J Eur Acad Dermatol Venereol 2019 08 3;33(8):1450-1451. Epub 2019 Apr 3.

Department of Dermatology, Allergology and Venereology, Helsinki University Central Hospital, Meilahdentie 2, PO Box 160, 00029 HUS, Helsinki, Finland.

Int J Dermatol 2019 Oct 20;58(10):1160-1164. Epub 2019 Feb 20.

Marshfield Medical Center, Marshfield, WI, USA.

Background: Bardet-Biedl syndrome (BBS) is a rare, pleiotropic syndrome and member of a diverse group of disorders known as ciliopathies. Improved understanding of dermatoses in BBS will further understanding of the syndrome and will help define the role of dermatologists in providing care for patients with BBS. The purpose of this study was to describe the cutaneous phenotype of BBS in patients attending a large, multispecialty BBS clinic. Read More

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Department of Dermatology, Hospital Universitario Fundacion Alcorcon, Madrid.

Vemurafenib, a kinase inhibitor that targets tumors with the BRAF V600E mutation, is a promising option for unresectable or metastatic melanoma. Cutaneous side-effects have been reported including alopecia, photosensitivity, squamous cell carcinoma, keratoacanthomas, keratosis pilaris-like eruption, and palmoplantar hyperkeratosis. Acneiform eruptions have been reported in 3%-6% of the patients treated with BRAF inhibitors,and 5 cases are described in the literature. Read More

Skinmed 2018;16(6):421-422. Epub 2018 Dec 21.

Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.

A 12-year-old girl was referred to the University Hospital of Southern Denmark with multiple small, punched-out scars on both cheeks, proximal and lateral on the nose, and in the auricular conchae. According to the history, the skin lesions had been progressing since the age of 3 years. The family had consulted several dermatologists and one plastic surgeon without any specific diagnosis or therapeutic solution. Read More

Am J Clin Dermatol 2019 02;20(1):165

Private practice, St Albans, UK.

Pediatr Dermatol 2019 Jan 26;36(1):e62-e63. Epub 2018 Nov 26.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Vemurafenib, a selective BRAF kinase inhibitor, has been found to induce several cutaneous adverse effects, ranging from a keratosis pilaris-like reaction to squamous cell carcinoma. While photosensitivity has been well described as one of these manifestations, we report a case of a 6-year-old boy on vemurafenib who developed a severe blistering sunburn after only two 30-minute episodes of sun exposure. A brief review of other common cutaneous adverse effects of vemurafenib is also provided. Read More

Br J Dermatol 2019 06 18;180(6):1438-1448. Epub 2019 Jan 18.

University of Paris-Diderot, Paris, France.

Background: Data on dermatological manifestations of Noonan syndrome (NS) remain heterogeneous and are based on limited dermatological expertise.

Objectives: To describe the dermatological manifestations of NS, compare them with the literature findings, and test for dermatological phenotype-genotype correlations with or without the presence of PTPN11 mutations.

Methods: We performed a large 4-year, prospective, multicentric, collaborative dermatological and genetic study. Read More

Eur J Dermatol 2018 Aug;28(4):566-567

Department of Dermatology and Venereology, Hospital de Santo António dos Capuchos - Centro Hospitalar de Lisboa Central, Alameda de Santo António dos Capuchos, 1169-050 Lisbon, Portugal.

J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1295

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetology, Saarland University Medical Center, Homburg, Germany.

With an incidence of 1 in 700 births, Down syndrome (DS) is not an uncommon condition. It is associated with various disorders of different organ systems. Serious disorders include cardiac defects and leukemia. Read More

J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1296

Universität des Saarlandes, Kliniken für Kinder- und Jugendmedizin, Sektion Pädiatrische Endokrinologie und Diabetologie, Homburg.

Das Down-Syndrom (DS) ist mit einer Inzidenz von 1 : 700 aller Geburten nicht selten und mit diversen Erkrankungen unterschiedlicher Organsysteme assoziiert. Zu den schwerwiegenden Erkrankungen zählen Herzfehler und Leukämie. Letztere zeigt sich im Neugeborenenalter und geht nicht immer in eine klassische myeloische Leukämie über (transiente myeloproliferative Erkrankung). Read More

J Cutan Pathol 2018 Dec 21;45(12):958-961. Epub 2018 Oct 21.

Department of Dermatology, University of California Irvine, Irvine, California.

Keratosis pilaris (KP) is a benign cutaneous disorder characterized by folliculocentric hyperkeratotic papules most often occurring on the proximal extremities. Erythema is usually limited to perifollicular skin, but when keratosis pilaris presents on a background of confluent erythema, the term keratosis pilaris rubra (KPR) is used. The histological findings associated with KP have not been well described in the literature. Read More

Am J Med Genet A 2018 11 23;176(11):2395-2403. Epub 2018 Sep 23.

Laboratory of Cytogenetics, Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia.

The application of array-based comparative genomic hybridization and next-generation sequencing has identified many chromosomal microdeletions and microduplications in patients with different pathological phenotypes. Different copy number variations are described within the short arm of chromosome 18 in patients with skin diseases. In particular, full or partial monosomy 18p has also been associated with keratosis pilaris. Read More

Clin Dermatol 2018 Sep - Oct;36(5):631-640. Epub 2018 Jun 1.

Department of Dermatology, Mt Sinai West, Icahn School of Medicine at Mt Sinai, New York, NY. Electronic address:

Atopic dermatitis is a common chronic pruritic inflammatory skin disorder, characterized by an abnormal skin barrier, immune dysfunction, and an altered skin microbiome. Atopic dermatitis may be seen in conjunction with a variety of other skin disorders due to the complex pathogenesis of atopic dermatitis, involving genetic and environmental factors that are associated with immune dysfunction, barrier defects, and altered skin microbiomes. Skin disorders associated with atopic dermatitis include diseases sharing similar genetic origins like ichthyosis vulgaris, infectious diseases such as impetigo, and eczema herpeticum, in addition to the cutaneous autoimmune diseases, alopecia areata, and vitiligo. Read More

Int J Dermatol 2018 11 27;57(11):e140-e141. Epub 2018 Aug 27.

Department of Dermatology, University of Health Sciences, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Lasers Med Sci 2018 Nov 24;33(8):1631-1637. Epub 2018 Aug 24.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., 2nd Floor, Unit 2099, Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA.

Usage of photopneumatic technology has recently increased for treatment of different skin conditions such as acne, keratosis pilaris (KP), and rosacea. Photopneumatic devices combine gentle negative pressure with broad band pulsed light simultaneously to attack multiple targets in the skin for better treatment outcomes. In this literature review, we evaluate the efficacy of photopneumatic therapy on treatment of acne, keratosis pilaris (KP), and rosacea. Read More

Br J Dermatol 2019 01 30;180(1):172-180. Epub 2018 Sep 30.

Department of Clinical Genetics, Arnaud de Villeneuve Hospital, University of Montpellier, Montpellier, France.

Background: Data on dermatological manifestations of cardiofaciocutaneous syndrome (CFCS) remain heterogeneous and almost without expert dermatological classification.

Objectives: To describe the dermatological manifestations of CFCS; to compare them with the literature findings; to assess those discriminating CFCS from other RASopathies, including Noonan syndrome (NS) and Costello syndrome (CS); and to test for dermatological phenotype-genotype correlations.

Methods: We performed a 4-year, large, prospective, multicentric, collaborative dermatological and genetic study. Read More

Indian J Dermatol Venereol Leprol 2018 Sep-Oct;84(5):591-594

Department of Dermatology, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Mol Med Rep 2018 Sep 31;18(3):3153-3158. Epub 2018 Jul 31.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Keratosis pilaris (KP) and nevus comedonicus (NC) are congenital keratinized dermatoses; however, the exact etiology of these two diseases is unclear. The objective of the present study was to identify the disease‑causing genes and their association with functional alterations in the development of KP and NC. Peripheral blood samples of one KP family, two NC families and 100 unrelated healthy controls were collected. Read More

Am J Clin Dermatol 2018 Oct;19(5):733-757

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 240 East 38th Street, 11th Floor, New York, NY, 10016, USA.

Keratosis pilaris is a common skin disorder comprising less common variants and rare subtypes, including keratosis pilaris rubra, erythromelanosis follicularis faciei et colli, and the spectrum of keratosis pilaris atrophicans. Data, and critical analysis of existing data, are lacking, so the etiologies, pathogeneses, disease associations, and treatments of these clinical entities are poorly understood. The present article aims to fill this knowledge gap by reviewing literature in the PubMed, EMBASE, and CINAHL databases and providing a comprehensive, analytical summary of the clinical characteristics and pathophysiology of keratosis pilaris and its subtypes through the lens of disease associations, genetics, and pharmacologic etiologies. Read More

BMC Med Genet 2018 07 18;19(1):120. Epub 2018 Jul 18.

Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan, 430000, China.

Background: X-linked ichthyosis (XLI) is a recessive keratinization condition caused by deficient activity of steroid-sulfatase due to mutations in steroid sulfatase (STS) gene located on the X chromosome. In contrast, ichthyosis vulgaris (IV) is caused by filaggrin deficiency due to semi-dominant loss-of-function mutations of filaggrin (FLG) gene. Filaggrin defects could synergize with XLI to exacerbate its phenotype. Read More

Acta Derm Venereol 2018 Aug;98(8):809-810

Department of Dermatology, "Emek" Medical Center, Afula, Israel.

J Cutan Med Surg 2018 Nov/Dec;22(6):621-623. Epub 2018 May 13.

4 Division of Clinical Dermatology and Cutaneous Science, Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Background: Dasatinib is a tyrosine kinase inhibitor indicated for the treatment of chronic myeloid leukemia (CML). Skin rashes are common, occurring in about a quarter of patients treated, and are generally mild. The commonest rash is a keratosis pilaris-like eruption. Read More

J Drugs Dermatol 2018 May;17(5):554-556

Chlorine dioxide complex™ is a new molecule to dermatology that is a unique, non-toxic, broad spectrum anti-microbial and keratolytic compound. Chlorine dioxide has been used as an antiseptic in industrial settings for decades, primarily in water treatment facilities for municipal water supplies and food preparation. The compound has exceptional antiseptic properties with no known potential for development of resistance. Read More