A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency.
- Christopher M Allan,
- Deanna Tran,
- Yiping Tu,
- Patrick J Heizer,
- Lorraine C Young,
- Loren G Fong,
- Anne P Beigneux,
- Stephen G Young
Exp Dermatol 2017 Apr 18. Epub 2017 Apr 18.
Divisions of Cardiology, University of California, Los Angeles, CA, 90095.
Mutations in SLURP1, a secreted protein of keratinocytes, cause a palmoplantar keratoderma (PPK) known as mal de Meleda. Slurp1 deficiency in mice faithfully recapitulates the human disease, with increased keratinocyte proliferation and thickening of the epidermis on the volar surface of the paws. There has long been speculation that SLURP1 serves as a ligand for a receptor that regulates keratinocyte growth and differentiation. Read More