2,225 results match your criteria Keratoacanthoma


Malignant transformation of a conjunctival keratoacanthoma requiring enucleation.

Clin Ter 2019 Mar-Apr;170(2):e81-e83

Ophthalmology Department. Hospital General. Granollers, España.

Purpose: We report a rare case of rapid transformation of a conjunctival keratoacanthoma (KA) into a highly aggressive squamous cell carcinoma requiring enucleation. To our knowledge, this is the second such case reported in the literature.

Methods: Case report. Read More

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http://dx.doi.org/10.7417/CT.2019.2113DOI Listing

Ineffectiveness of radiotherapy for the treatment of keratoacanthoma centrifugum marginatum: A case report.

Dermatol Ther 2019 Apr 12:e12920. Epub 2019 Apr 12.

Department of Dermatology, Hitachi General Hospital, Hitachi, Japan.

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http://dx.doi.org/10.1111/dth.12920DOI Listing

Patterns of LC3A Autophagy Protein Expression in Keratoacanthomas.

Head Neck Pathol 2019 Apr 11. Epub 2019 Apr 11.

Departments of Pathology, Democritus University of Thrace Medical School and University General Hospital of Alexandroupolis, 68100, Alexandroupolis, Greece.

To investigate the expression patterns of autophagy marker light chain protein 3 (LC3A) in keratoacanthoma (KA). KAs are generally regarded as benign but malignant behavior, including rare metastases, may occur. 85 KAs were assessed for the LC3A autophagic protein by immunohistochemistry. Read More

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http://dx.doi.org/10.1007/s12105-019-01033-1DOI Listing

Aberrant expression and high-frequency mutations of in nonmelanoma skin cancer.

Exp Ther Med 2019 Apr 12;17(4):2746-2756. Epub 2019 Feb 12.

Department of Dermatology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518100, P.R. China.

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) have exhibited a marked increase in incidence in previous decades and are the most common malignancies in Caucasian populations. Src homology 3 and multiple ankyrin repeat domains protein-associated RH domain-interacting protein (SHARPIN) has been identified as a commonly overexpressed proto-oncogene in several types of visceral cancer. However, to the best of our knowledge, the functions of SHARPIN in nonmelanoma skin cancer (NMSC) have not been described. Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7261
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http://dx.doi.org/10.3892/etm.2019.7261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434243PMC
April 2019
7 Reads

Intralesional therapy for the treatment of keratoacanthoma.

Dermatol Ther 2019 Mar 13:e12872. Epub 2019 Mar 13.

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.

Keratoacanthoma (KA) is a common epidermal tumor that originates from the hair follicle of the skin. It is generally considered as a benign neoplasm, but in rare cases, it can also transform into squamous cell carcinoma. Although surgical excision with a safety margin is considered to be the gold standard treatment for most subtypes of KA, several other treatment options are also available. Read More

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http://dx.doi.org/10.1111/dth.12872DOI Listing
March 2019
6 Reads

XB130 deficiency enhances carcinogen-induced skin tumorigenesis.

Carcinogenesis 2019 Mar 1. Epub 2019 Mar 1.

Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network.

XB130 is an adaptor protein that functions as a mediator of multiple tyrosine kinases important for regulating cell proliferation, survival, migration and invasion. Formerly predicted as an oncogene, alterations of its expression are documented in various human cancers. However, the exact role of XB130 in tumorigenesis is unknown. Read More

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http://dx.doi.org/10.1093/carcin/bgz042DOI Listing
March 2019
2 Reads
5.334 Impact Factor

Successful Treatment of Generalized Eruptive Keratoacanthoma of Grzybowski with Acitretin.

Dermatol Ther (Heidelb) 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.

Introduction: Keratoacanthomas (KA) are common cutaneous skin tumors originating from the hair follicles. Unlike squamous cell carcinoma, KA can regress spontaneously and have a benign evolution. Solitary KA is the most common form but familial multiple KA (Ferguson-Smith type), genetically predisposed KA (such as in xeroderma pigmentosum, or Muir-Torre syndrome), or sporadic multiple eruptive KA (Grzybowski type) have been described. Read More

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http://dx.doi.org/10.1007/s13555-019-0287-0DOI Listing
February 2019
5 Reads

Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience.

Dermatol Ther (Heidelb) 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

Introduction: Keratoacanthomas are cutaneous neoplasms known for their rapid growth and spontaneous regression over a long time period. Their treatment can be difficult because of the potentially large field size and number of lesions. Intralesional methotrexate constitutes an effective, nonsurgical treatment of keratoacanthomas, as proven by our experience. Read More

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http://dx.doi.org/10.1007/s13555-019-0286-1DOI Listing
February 2019

Koebnerization of Eruptive Keratoacanthoma Into Lesions of Classic Lichen Planus Treated With Oral Acitretin.

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

DermSurgery Associates, Houston, Texas Dermatology Associates of Sugar Land, Sugar Land, Texas DermSurgery Associates, Houston, Texas Department of Medicine Houston Methodist Hospital, Houston, Texas Department of Dermatology, Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1097/DSS.0000000000001793DOI Listing
February 2019
3 Reads

Angiolymphoid hyperplasia with eosinophilia with clinical pictures of keratoacanthoma: A rare case report.

Clin Case Rep 2019 Jan 4;7(1):189-192. Epub 2018 Dec 4.

Sanglah General Public Hospital Denpasar Indonesia.

Angiolymphoid Hyperplasia with Eosinophilia (ALHE) is a benign tumor of the skin which may mimic other benign or malignant lesion of the skin. Practitioners should consider this diagnosis as a differential when encounter such lesion as papule or nodule on the face and scalp area. Read More

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http://dx.doi.org/10.1002/ccr3.1949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332754PMC
January 2019
5 Reads

Management of Keratoacanthoma: 157 Tumors Managed With Surgery or Intralesional Methotrexate.

Dermatol Surg 2019 Jan 2. Epub 2019 Jan 2.

The Skin Cancer Surgery Center, Anne Arundel Dermatology, Bethesda, Maryland.

Background: Keratoacanthomas (KAs) are common tumors of squamous cell origin that grow rapidly and may regress; however, differentiation from an aggressive squamous cell carcinoma is problematic.

Objective: To report the authors' experience in managing KA with intralesional methotrexate (MTX) or surgical excision.

Materials And Methods: The authors collected data on 157 tumors (136 patients) over 6 months from a single institution. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001739DOI Listing
January 2019
1 Read

Eyelid molluscum contagiosum presenting as a giant solitary ulcerating mass.

Saudi J Ophthalmol 2018 Oct-Dec;32(4):338-340. Epub 2018 Feb 8.

Oculoplastics and Orbit Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Molluscum contagiosum is a benign viral cutaneous infection. It typically presents as an asymptomatic centrally umbilicated nodule 3-5 mm in diameter. Susceptible patients are children and adults receiving immunosuppressive therapy. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300784PMC
February 2018
2 Reads

Efficacy and Safety of Intralesional Methotrexate in the Treatment of a Large Keratoacanthoma of the Dorsal Hand in a 99-Year-Old Woman.

Case Rep Dermatol 2018 Sep-Dec;10(3):247-250. Epub 2018 Nov 14.

Medical Department, Cantabria Labs Difa Cooper, Caronno Pertusella, Italy.

Several case reports and retrospective studies have demonstrated that intralesional methotrexate (MTX) could be a very effective and safe alternative treatment of keratoacanthoma (KA). Here, we report a rapid clinical efficacy of two intralesional MTX injections (total dose 40 mg) that were performed 1 week apart in the treatment of a large KA lesion of the dorsal hand in a 99-year-old woman. The lesion, with a 3-cm major axis diameter and a thickness of 2 cm with a central ulceration had rapidly appeared on the right dorsal hand. Read More

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http://dx.doi.org/10.1159/000494322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276738PMC
November 2018
4 Reads

Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis.

Case Rep Oncol 2018 Sep-Dec;11(3):671-675. Epub 2018 Oct 24.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Keratoacanthoma centrifugum marignatum (KCM) is a rare variant of keratoacanthoma, which is characterized by the dense infiltration of inflammatory cells throughout the dermis, especially around the keratinocytic islands. Therefore, it is sometimes difficult to differentiate between KCM and cutaneous T-cell lymphomas. In this report, we describe a case of KCM with spontaneous regression that showed dense infiltration of CD3+CD8+ T cells. Read More

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http://dx.doi.org/10.1159/000493089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244034PMC
October 2018
4 Reads

Multiple disseminated keratoacanthoma-like nodules: a rare form of distant metastases to the skin.

Postepy Dermatol Alergol 2018 Oct 19;35(5):535-537. Epub 2018 Jul 19.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

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https://www.termedia.pl/doi/10.5114/ada.2018.77245
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http://dx.doi.org/10.5114/ada.2018.77245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232540PMC
October 2018
15 Reads

Sporotrichoid Keratoacanthomas: Case Report and Review of Neoplasms Presenting in a Sporotrichoid Pattern.

Cureus 2018 Aug 23;10(8):e3196. Epub 2018 Aug 23.

Dermatologist, San Diego Family Dermatology, San Diego, USA.

Sporotrichosis is a fungal infection known for its distinct pattern of infectious skin nodules. Several conditions can present with lesions that appear in a sporotrichoid pattern. An 82-year-old man that presented with three cutaneous nodules on his right leg in a sporotrichoid manner is described; biopsy of each lesion revealed a keratoacanthoma. Read More

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https://www.cureus.com/articles/14274-sporotrichoid-keratoac
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http://dx.doi.org/10.7759/cureus.3196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200441PMC
August 2018
13 Reads

Case of keratoacanthoma centrifugum marginatum treated with acitretin.

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Department of Dermatology, Medway NHS Foundation Trust, Gillingham, UK.

Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA), characterised by a progressively expanding tumour with a lack of spontaneous remission and significant scarring. KCM has been reported previously in less than 50 cases worldwide. We present the case of a large solitary KCM on the right shin of a 71-year-old woman. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22681
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http://dx.doi.org/10.1136/bcr-2018-226818DOI Listing
November 2018
21 Reads

Keratoacanthoma-like cutaneous metastases in a case of squamous cell carcinoma of the tongue.

Indian J Dermatol Venereol Leprol 2018 Oct 29. Epub 2018 Oct 29.

Department of Dermatology and Venereology, Goa Medical College, North Goa, Goa, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_595_17DOI Listing
October 2018
2 Reads
1.325 Impact Factor

Eruptive keratoacanthoma with spontaneous regression arising from a cervical squamous cell carcinoma patient treated with nivolumab.

J Dermatol 2018 Oct 24. Epub 2018 Oct 24.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1111/1346-8138.14684DOI Listing
October 2018
1 Read

Systematic review and meta-analysis of prevalence of dermatological toxicities associated with vemurafenib treatment in patients with melanoma.

Authors:
P Chen F Chen B Zhou

Clin Exp Dermatol 2019 Apr 2;44(3):243-251. Epub 2018 Oct 2.

Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Vemurafenib has been linked to dermatological adverse events in patients with melanoma, including an increased risk of rash, cutaneous squamous cell carcinoma, photosensitivity reaction and keratoacanthoma. However, there has been no systematic attempt to assess the dermatological toxicity data of vemurafenib associated with melanoma treatment.

Aim: To evaluate the point prevalence of dermatological toxicities associated with vemurafenib treatment in patients with melanoma. Read More

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http://dx.doi.org/10.1111/ced.13751DOI Listing
April 2019
4 Reads

[Keratoacanthoma of the left forearm].

Pan Afr Med J 2018 5;30:12. Epub 2018 May 5.

Service de Dermatologie Hôpital Militaire d'Instruction Mohamed V, Rabat, Maroc.

We here report the case of a 54-year old woman presenting with a swelling in the left forearm occurred eight weeks before and rapidly increasing in volume. Clinical examination showed ulcero-budding painless purplish skin lesion measuring 2 cm along its longer axis (A). The patient underwent simple biopsy. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.12.15293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110548PMC
September 2018
17 Reads

Embedded Tooth: Unique Mimicker of Keratoacanthoma.

J Oral Maxillofac Surg 2018 Nov 30;76(11):2360.e1-2360.e2. Epub 2018 Jul 30.

Private Practitioner, Department of Dermatology, Hospital de Clinicas da Universidade Federal do Parana, Curitiba, Brazil.

A 58-year-old woman presented with a 30-day history of a moderately painful enlarging nodule on her upper cutaneous lip. Two weeks prior to presentation, she fell on the sidewalk leading to injuries of the oral mucosa, right temple, and knees. Physical examination revealed a 1. Read More

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http://dx.doi.org/10.1016/j.joms.2018.07.026DOI Listing
November 2018
1 Read

Multiple reactive keratoacanthomas treated with zinc oxide wraps and intralesional corticosteroids.

JAAD Case Rep 2018 Aug 15;4(7):701-704. Epub 2018 Aug 15.

Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098212PMC

A prospective diagnostic study on povidone-iodine retention in lesions suspected to be squamous cell carcinoma or keratoacanthoma.

Australas J Dermatol 2019 Feb 15;60(1):e33-e39. Epub 2018 Aug 15.

Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Background And Objectives: While dermatoscopy improves diagnostic accuracy for raised nonpigmented lesions, those with white surface keratin can be problematical. We investigated whether retention of povidone-iodine by surface keratin provides a clue to benignity.

Methods: We performed a retrospective pilot study (n = 57) followed by a prospective study (n = 117) on raised nonpigmented lesions with white surface keratin. Read More

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http://dx.doi.org/10.1111/ajd.12897DOI Listing
February 2019
21 Reads

Vemurafenib.

Recent Results Cancer Res 2018;211:77-89

Division of Dermatooncology, Department of Dermatology, University Medical Centre, Liebermeisterstr. 25, 72074, Tuebingen, Germany.

The activating BRAF mutation V600E and related mutations in this codon are most important for the activation of the RAS/RAF/MEK/ERK mitogen-activated protein kinase (MAPK) signalling pathway in melanoma. BRAF V600E mutations have been detected in ~40% of melanoma patients and BRAF V600K mutations in ~5% of melanoma patients. Activation of the MAPK pathway results in continuous stimulation of cell proliferation and inhibits programmed cell death. Read More

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http://dx.doi.org/10.1007/978-3-319-91442-8_6DOI Listing
November 2018
4 Reads

A Multiple Recurrent Keratoacanthoma of the Lower Leg After Repeated Wide-Excision and Mohs Micrographic Surgery.

Dermatol Surg 2018 07;44(7):1028-1030

Marmur Medical, New York, New York Department of Dermatology, University of California, Irvine, Irvine, California Marmur Medical, New York, New York Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1097/DSS.0000000000001422DOI Listing
July 2018
6 Reads

Topical aminolevulinic acid-photodynamic therapy in the treatment of keratoacanthoma: A case report.

Photodiagnosis Photodyn Ther 2018 09 18;23:151-153. Epub 2018 Jun 18.

Department of Dermatology, Huadong Hospital, Fudan University, Shanghai 200040, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15721000183011
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http://dx.doi.org/10.1016/j.pdpdt.2018.06.005DOI Listing
September 2018
9 Reads

Shisha use among students in a private university in Kigali city, Rwanda: prevalence and associated factors.

BMC Public Health 2018 Jun 8;18(1):713. Epub 2018 Jun 8.

Department of Public Health, Mount Kenya University, School of Health Sciences, P. O. Box 5826, Kigali Campus, Kigali, Rwanda.

Background: All over the globe shisha smoking is fast growing among different age brackets. Shisha use has been reported to be increasing among youths in African major cities. Its use is documented to result in health effects such as lung cancer, cardiovascular and respiratory conditions, periodontal diseases, keratoacanthoma which are also associated with cigarette smoking. Read More

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http://dx.doi.org/10.1186/s12889-018-5596-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994055PMC
June 2018
1 Read

An odd very early marjolin's ulcer after minimal hand burn.

Ann Burns Fire Disasters 2017 Sep;30(3):218-219

Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Marjolin's ulcer refers to any malignant transformation of chronic wounds. Different chronic wounds may be transformed into malignancies, although they usually have a latency period of between 25 to 40 years after the primary injury. We herein present an otherwise healthy man who developed squamous cell carcinoma (SCC) three weeks after burn injury. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946743PMC
September 2017
3 Reads

T-lymphocyte profiles differ between keratoacanthomas and invasive squamous cell carcinomas of the human skin.

Cancer Immunol Immunother 2018 07 24;67(7):1147-1157. Epub 2018 May 24.

Department of Dermatology, Venereology and Allergy, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University and Centre of Excellence of Dermatology of Baden-Württemberg, Mannheim, Germany.

Background: T-lymphocytes are involved in tumor progression and regression. Actinic keratoses (AK) are atypical proliferations of keratinocytes of the skin. Some AK progress into invasive cutaneous squamous cell carcinomas (cSCC). Read More

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http://dx.doi.org/10.1007/s00262-018-2171-7DOI Listing
July 2018
5 Reads

Solitary Palmar Keratoacanthoma: Case Report.

Cureus 2018 Mar 15;10(3):e2331. Epub 2018 Mar 15.

Dermatology, Derm Surgery Associates, PA.

Keratoacanthoma (KA) is a squamous neoplasm exhibiting a triphasic growth pattern involving rapid growth, stabilization, and eventual spontaneous resolution. Historically, keratoacanthomas were thought to originate on hair-bearing skin or sun-exposed surfaces. However, recent reports demonstrate that they can occur on the mucous membranes, subungual regions, and palms and soles. Read More

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http://dx.doi.org/10.7759/cureus.2331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953505PMC
March 2018
5 Reads

Prevalence and molecular characteristics of DNA mismatch repair protein-deficient sebaceous neoplasms and keratoacanthomas in a Japanese hospital-based population.

Jpn J Clin Oncol 2018 Jun;48(6):514-521

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

Background: Muir-Torre syndrome (MTS) is currently considered as a clinical variant of Lynch syndrome (LS). The clinical significance of the screening of patients with MTS-associated cutaneous tumors for the identification of LS has not yet been established. In addition, the prevalence and molecular characteristics of mismatch repair (MMR) protein deficiency in such tumors has scarcely been investigated in the Japanese population. Read More

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http://dx.doi.org/10.1093/jjco/hyy055DOI Listing
June 2018
16 Reads

Distinct variants affecting differential splicing of TGFBR1 exon 5 cause either Loeys-Dietz syndrome or multiple self-healing squamous epithelioma.

Eur J Hum Genet 2018 08 30;26(8):1151-1158. Epub 2018 Apr 30.

Department of Cardiovascular Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Tokyo, 113-8655, Japan.

Variants in TGFBR1 have been reported to induce two completely distinct diseases, namely Loeys-Dietz syndrome (LDS) and multiple self-healing squamous epithelioma (MSSE). However, detailed mechanisms underlying this effect remain unknown. We report a Japanese familial case of LDS with a novel splice donor site variant in TGFBR1 gene (c. Read More

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http://dx.doi.org/10.1038/s41431-018-0127-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057981PMC
August 2018
9 Reads

Mohs micrographic surgery for nail unit tumours: an update and a critical review of the literature.

J Eur Acad Dermatol Venereol 2018 Oct 27;32(10):1638-1644. Epub 2018 May 27.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Mohs micrographic surgery (MMS) is a good treatment option for epithelial neoplasms, especially when localized in areas where tissue conservation is crucial, such as the nail unit (NU). MMS is a method of radical excision offering high cure rates due to the margin control and functional preservation. Our aim is to provide a review on the use of MMS for the treatment of the most common nail tumours. Read More

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http://dx.doi.org/10.1111/jdv.15036DOI Listing
October 2018
6 Reads

Keratoacanthomatous Changes: Unifying the Histologic Spectrum of Actinic Granuloma.

Am J Dermatopathol 2018 Oct;40(10):762-766

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.

Actinic granuloma (AG) manifests as annular plaques on sun-damaged skin. There remains no universal consensus on the nosology, etiology, or clinicopathologic criteria of AG as a distinct entity. Broadly, AG is characterized by granulomatous inflammation, multinucleated giant cells, elastophagocytosis, and the absence of mucin and necrobiosis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001156DOI Listing
October 2018
4 Reads

Dermatologic toxicity from novel therapy using antimicrobial peptide LL-37 in melanoma: A detailed examination of the clinicopathologic features.

J Cutan Pathol 2018 Jul 16;45(7):539-544. Epub 2018 May 16.

Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.

LL-37 is a naturally occurring 37-amino-acid peptide that is part of the innate immune system in human skin. Preclinical studies have showed that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a phase 1 clinical trial for melanoma patients with cutaneous metastases. Read More

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http://dx.doi.org/10.1111/cup.13262DOI Listing
July 2018
17 Reads
1.560 Impact Factor

[III. Diagnosis and Management of Keratoacanthoma].

Authors:
Toshihiro Takai

Gan To Kagaku Ryoho 2018 Apr;45(4):622-624

Dept. of Dermatology, Hyogo Cancer Center.

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Perforating osteoma cutis: case report and literature review of patients with a solitary perforating osteoma cutis lesion.

Authors:
Philip R Cohen

Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.

Department of Dermatology, University of California San Diego, La Jolla, California, USA.

Osteoma cutis, the development of bone in the dermis and/or subcutaneous fat, can occur as either a primary or secondary condition. Perforating osteoma cutis is rare. A man with a solitary lesion of perforating osteoma cutis is described and the features of individuals with a single perforating osteoma cutis skin lesion are reviewed. Read More

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March 2018
11 Reads

Topical Imiquimod 5% as a Treatment Option in Solitary Facial Keratoacanthoma.

Open Access Maced J Med Sci 2018 Mar 8;6(3):531-535. Epub 2018 Mar 8.

University Clinic of Dermatology, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Keratoacanthoma (KA) is a rapidly growing epithelial tumour with histopathologic and clinical features similar to squamous cell carcinoma (SCC) and a certain tendency toward spontaneous regression.

Case Presentation: This article presents a unique and rare case of keratoacanthoma arising from the upper lip of a young male patient. These two features are in contrast to most of the reported cases in elder male individuals and on the lower lip. Read More

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http://dx.doi.org/10.3889/oamjms.2018.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874379PMC
March 2018
13 Reads

KERATOACANTHOMA OF THE UPPER LIP: REVIEW OF THE LITERATURE AND REPORT OF CASE WITH CENTRAL UPPER LIP RECONSTRUCTION.

Authors:
A Goldman U Wollina

Georgian Med News 2018 Feb(Issue):77-80

Clinica Goldman, Porto Alegre, Rio Grande do Sul, Brazil; Department of Dermatology and Allergology, Municipal Hospital Dresden, Academic Teaching Hospital of the Technical University of Dresden, Germany.

Keratoakanthoma (KA) is a common non-melanoma skin tumor of sun-exposed skin. Recently it has been classified as a highly differentiated squamous cell carcinoma, based on the evidence of local destruction, tissue invasion and malignant transformation with metastatic spread described in the medical literature. Lower lip KA is not uncommon on lower lip, and quite rare on upper lip. Read More

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February 2018

Multiple keratoacanthoma and oral lichen planus successfully treated with systemic retinoids and review of multiple keratoacanthoma associated with lichen planus.

Int J Dermatol 2018 09 25;57(9):1125-1127. Epub 2018 Mar 25.

Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1111/ijd.13974DOI Listing
September 2018
6 Reads

Epidemiology of skin cancer in the mature patient.

Clin Dermatol 2018 Mar - Apr;36(2):167-176. Epub 2017 Oct 13.

Sinclair Dermatology, East Melbourne, VIC Australia; Faculty of Medicine, The University of Melbourne, Parkville, VIC Australia. Electronic address:

Epidermal cancers include keratinocyte cancer, melanocyte cancer, and Merkel cell carcinoma. These cancers account for the vast majority of new cancers diagnosed in Australia, North America, and Europe. Keratinocyte cancer is the most common epidermal cancer and accounts for 7 out of 8 new cancers diagnosed in Australia. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.10.008DOI Listing
September 2018
7 Reads

Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.

Lancet Oncol 2018 04 21;19(4):510-520. Epub 2018 Feb 21.

Department of Dermatology, University Hospital Essen, Essen, Germany; German Cancer Consortium, Heidelberg, Germany.

Background: Systemic adjuvant treatment might mitigate the high risk of disease recurrence in patients with resected stage IIC-III melanoma. The BRIM8 study evaluated adjuvant vemurafenib monotherapy in patients with resected, BRAF mutation-positive melanoma.

Methods: BRIM8 was a phase 3, international, double-blind, randomised, placebo-controlled study that enrolled 498 adults (aged ≥18 years) with histologically confirmed stage IIC-IIIA-IIIB (cohort 1) or stage IIIC (cohort 2) BRAF mutation-positive melanoma that was fully resected. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30106-2DOI Listing
April 2018
19 Reads

β-HPV Infection Correlates with Early Stages of Carcinogenesis in Skin Tumors and Patient-Derived Xenografts from a Kidney Transplant Recipient Cohort.

Front Microbiol 2018 5;9:117. Epub 2018 Feb 5.

Virology Unit, Department of Translational Medicine, Novara Medical School, University of Eastern Piedmont, Novara, Italy.

Many malignancies that occur in high excess in kidney transplant recipients (KTRs) are due to viruses that thrive in the setting of immunosuppression. Keratinocyte carcinoma (KC), the most frequently occurring cancer type in KTR, has been associated with skin infection by human papillomavirus (HPV) from the beta genus. In this report, we extend our previous investigation aimed at identifying the presence of active β-HPV infection in skin tumors from KTRs through detection of viral protein expression. Read More

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http://dx.doi.org/10.3389/fmicb.2018.00117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807414PMC
February 2018
13 Reads

Cutaneous intravascular CD30+ T-cell pseudolymphoma occurring in a regressing keratoacanthoma.

J Cutan Pathol 2018 Apr 18;45(4):296-298. Epub 2018 Feb 18.

Associates in Dermatology, MD PL, Fort Myers, Florida.

Cutaneous intravascular CD30+ pseudolymphoma is an uncommon incidental finding that may mimic intravascular or angiotropic lymphoma. We describe a 78-year-old female with a traumatized regressing keratoacanthoma on her left cheek. A shave biopsy revealed intravascular staining of atypical lymphocytes positive for CD45, CD3 and CD30. Read More

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http://doi.wiley.com/10.1111/cup.13111
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http://dx.doi.org/10.1111/cup.13111DOI Listing
April 2018
23 Reads

Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report.

Dermatol Ther (Heidelb) 2018 Mar 24;8(1):143-146. Epub 2018 Jan 24.

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Caserta, Italy.

Introduction: Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300-700 fold has been intensely investigated.

Case Presentation: Keratoacanthoma in an 86-year-old patient was treated with intralesional bleomycin combined with electroporation. Read More

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http://dx.doi.org/10.1007/s13555-018-0222-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825327PMC
March 2018
4 Reads

Eruptive keratoacanthomas secondary to nivolumab immunotherapy.

Int J Dermatol 2018 03 10;57(3):e28-e29. Epub 2018 Jan 10.

Department of Pathology, Division of Dermatopathology, Geisinger Medical Center, Danville, PA, USA.

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http://dx.doi.org/10.1111/ijd.13893DOI Listing
March 2018
6 Reads

Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats.

Regul Toxicol Pharmacol 2018 Feb 24;92:382-389. Epub 2017 Dec 24.

Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

Vismodegib (also known as GDC-0449) is a novel small molecule inhibitor of the Hedgehog (Hh) signaling pathway currently approved for the treatment of metastatic or locally advanced basal cell carcinoma (BCC) in humans. Its tumorigenic potential was assessed in dedicated carcinogenicity studies in rasH2 transgenic (Tg.rasH2) mice and Sprague Dawley (SD) rats. Read More

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http://dx.doi.org/10.1016/j.yrtph.2017.12.015DOI Listing
February 2018
47 Reads