2,302 results match your criteria Keratoacanthoma


An Analysis of Biopsies for Suspected Skin Cancer at a Tertiary Care Dermatology Clinic in the Western Cape Province of South Africa.

J Skin Cancer 2020 27;2020:9061532. Epub 2020 Jan 27.

Division of Dermatology, Department of Medicine, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa.

Background: Skin cancer is a growing health concern worldwide. It is the most common malignancy in South Africa and places a large burden on the public healthcare sector. There is a paucity of published scientific data on skin cancer in South Africa. Read More

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http://dx.doi.org/10.1155/2020/9061532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204328PMC
January 2020

Altered hydroxymethylation in cutaneous squamous cell carcinoma and keratoacanthoma.

Br J Dermatol 2020 May 14. Epub 2020 May 14.

Translational Skin Cancer Research, DKTK Partner Site Essen/Düsseldorf, West German Cancer Center, Dermatology, University Duisburg-Essen, Essen, Germany.

We studied formalin-fixed and paraffin-embedded tissue of patients with cSCC, AK, and KA. We included only lesions that were located on the head and neck region. The study was approved by the ethics review board of the Ruhr-University Bochum (#16-5985). Read More

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http://dx.doi.org/10.1111/bjd.19219DOI Listing

Comment on: "Intralesional methotrexate for keratoacanthomas: a retrospective cohort study".

J Am Acad Dermatol 2020 May 5. Epub 2020 May 5.

Department of Dermatology, University Clinic of Navarra, School of Medicine, University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1016/j.jaad.2020.04.162DOI Listing

Photodynamic therapy for keratoacanthoma on the upper lip.

Photodiagnosis Photodyn Ther 2020 Apr 29:101798. Epub 2020 Apr 29.

Department of Dermatology, Maoming People's hospital, Maoming, Guangdong, China. Electronic address:

Background: Keratoacanthoma (KA) is a cutaneous neoplasm, which is similar to squamous cell carcinoma (SCC) clinically, cytologically, and histopathologically. Surgical resection is the first choice for treating KA, but it may be impractical when a KA is located in a cosmetically sensitive area.

Observation: We describe a patient with a nodule on the right upper lip. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101798DOI Listing

Tumor immunotherapy - A lot to learn from Keratoacanthoma.

Med Hypotheses 2020 Apr 7;141:109719. Epub 2020 Apr 7.

Department of Maxillofacial Surgery and Diagnostic Science, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Dysfunctionalinty and exhaustion of T cells in the tumor microenvironment is a harsh reality of anti-tumor immune response where tumor cells can escape it. A considerable effort is going on in the field of research that tries to harness the power of T cells against cancer cells to design new anti-cancer immunotherapeutic designs. All these efforts are getting a setback due to the fact that T cells become dysfunctional in tumors while expressing exhaustion markers, so it is necessary to understand from the perspective of cancer itself that what is lacking in tumor-specific T cells in tumor microenvironment so they are getting evaded. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109719DOI Listing

Keratoacanthoma centrifugum marginatum associated with mechanical trauma: Response to acitretin-A case report and review of the literature.

Dermatol Ther 2020 Apr 10:e13397. Epub 2020 Apr 10.

Clinic of Dermatolovenereology, Clinical Center of Serbia, Belgrade, Serbia.

Keratoacanthoma centrifugum marginatum (KCM) is a very rare variant of keratoacanthoma, characterized with progressive centrifugal growth, central healing, and atrophy. Due to its rarity and lack of distinctive histopathological features, KCM often raises diagnostic and therapeutic challenge. We present a case of a 76-year-old Caucasian woman with a single large tumor on her right shin that responded to oral retinoids. Read More

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http://dx.doi.org/10.1111/dth.13397DOI Listing

Onycholemmal variant of keratoacanthoma centrifugum marginatum as an expression of mutated committed stem cells in a conceptual pathway.

Australas J Dermatol 2020 Mar 12. Epub 2020 Mar 12.

Newcastle Dermatology, Georgetown, New South Wales, Australia.

We describe a 43-year-old woman with a 10-year history of grossly hyperkeratotic nodules which progressively extended over the right ring finger. These involuted leaving pale, atrophic skin in their wake. At presentation, the advancing border had an arciform series of nodules in the pattern of keratoacanthoma centrifugum marginatum. Read More

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http://dx.doi.org/10.1111/ajd.13271DOI Listing

When to suspect a non-melanoma skin cancer.

BMJ 2020 Mar 11;368:m692. Epub 2020 Mar 11.

Department of Dermatology, Nottingham NHS Treatment Centre, Nottingham NG7 2FT, UK.

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http://dx.doi.org/10.1136/bmj.m692DOI Listing

Efficacy of oral retinoids for keratoacanthoma centrifugum marginatum.

Dermatol Ther 2020 Mar 3:e13291. Epub 2020 Mar 3.

Department of Dermatologic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma. This condition is difficult to diagnose because of its large size and expansive nature and may be diagnosed as a malignant tumor. There are various treatments such as surgery and oral retinoids; however, limited studies have verified their effectiveness. Read More

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http://dx.doi.org/10.1111/dth.13291DOI Listing

Do Not Judge a Book by its Cover: Masquerading as Keratoacanthoma.

Acta Derm Venereol 2020 Mar 12;100(6):adv00074. Epub 2020 Mar 12.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, PL-50-368 Wroclaw, Poland.

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http://dx.doi.org/10.2340/00015555-3423DOI Listing

Skin Metastasis of Laryngeal Carcinoma Presenting as Multiple Eruptive Nodules.

Head Neck Pathol 2020 Feb 10. Epub 2020 Feb 10.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Metastasis of head and neck squamous cell carcinoma (SCC) to the skin of this region is extremely rare and reported in 1-2% of cases. The cutaneous metastases of head and neck cancers often present as multiple papulonodular lesions; however, sporadic cases of solitary or multiple keratoacanthoma-like lesions are reported. We describe a rare case of cutaneous metastases of laryngeal SCC presenting as multiple eruptive keratoacanthoma-like lesions with concomitant scrofuloderma in an area of previous radiotherapy. Read More

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http://dx.doi.org/10.1007/s12105-020-01143-1DOI Listing
February 2020

Quality assessment of a large primary GP skin cancer service in Auckland, New Zealand.

N Z Med J 2020 02 7;133(1509):17-27. Epub 2020 Feb 7.

Cutaneous Surgical Oncologist, Department of Cutaneous Oncology, North Shore Hospital, Waitemata District Health Board, Auckland.

Aim: Waitemata District Health Board has implemented a new approach to the management of skin cancers by triaging lesions to specialist-trained general practitioners (GPSI) with the aim of reducing patient wait times and treatment costs. The primary outcome was to determine positive margin rates for the GP surgeons, with secondary outcome being infection rates.

Method: A retrospective audit was conducted on all excisions (n=2,705) performed between 1 January 2016 and 31 December 2016 by the 13 WDHB GPSIs. Read More

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February 2020

Human Orf: An Under-recognized Entity.

Acta Dermatovenerol Croat 2019 Dec;27(4):280-281

Luis Santiago, MD, Dermatology Department Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal;

Dear Editor, Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats, and humans are infected either through direct transmission from active lesions on infected animals or through contact with fomites (2). Orf is an occupational hazard and the population at risk includes shepherds, butchers, farmers, wool shearers, and veterinarians (2,3). Read More

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December 2019

Chemical composition and distribution of tattoo inks within tattoo-associated keratoacanthoma.

J Eur Acad Dermatol Venereol 2020 Jan 21. Epub 2020 Jan 21.

«Tattoo» Consultation, Department of Dermatology, Bichat-Claude Bernard Hospital, HUPNVS, Paris, France.

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http://dx.doi.org/10.1111/jdv.16220DOI Listing
January 2020

An exophytic and symptomatic lesion of the labial mucosa diagnosed as labial seborrheic keratosis.

Int J Clin Exp Pathol 2019 1;12(7):2749-2752. Epub 2019 Jul 1.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu 610041, Sichuan, P. R. China.

Seborrheic keratosis is a common benign epidermal tumor that occurs mainly in the skin of the face and neck, trunk. The tumors are not, however, seen on the oral mucous membrane. Herein, we describe a case of labial seborrheic keratosis confirmed by histopathology. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949549PMC

Cutaneous Nodules Arranged in a Sporotrichoid Distribution Over the Lower Extremity.

Dermatol Pract Concept 2020 31;10(1):e2020013. Epub 2019 Dec 31.

Department of Dermatology, University General Hospital of Patras, Greece.

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http://dx.doi.org/10.5826/dpc.1001a13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936638PMC
December 2019

A giant keratoacanthoma of the cheek.

Acta Biomed 2019 12 23;90(4):580-582. Epub 2019 Dec 23.

Division of Plastic and Reconstructive Surgery; Department of Medicine, Surgery and Neuroscience; University Hospital "Santa Maria alle Scotte", Siena, Italy; University of Siena.

Keratoacanthoma (KA) is a cutaneous tumor arising on sun-exposed skin and characterized by self-limiting growth and involution. We reported a case of a 92-year-old man presented a 4.5x3. Read More

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http://dx.doi.org/10.23750/abm.v90i4.7409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233768PMC
December 2019

Reconstruction of Small and Medium-Sized Nasal Defects Using an Omega Advancement Flap.

J Craniofac Surg 2020 May/Jun;31(3):772-774

Başkent Universitesi, Konya Uygulama ve Araştirma Hastanesi, Department of Plastic Surgery, Konya, Turkey.

Introduction: The nose is the most common area where malignant skin tumors occur. Repair with a flap after tumor excision provides esthetically and functionally acceptable results. In this study, we aimed to present the use of an omega (Ω) advancement flap, which can be applied in all anatomic regions of the nose, in 2 cm or smaller defects. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006104DOI Listing
January 2020

Differentiating keratoacanthoma from squamous cell carcinoma-In quest of the holy grail.

J Cutan Pathol 2020 Apr 14;47(4):418-420. Epub 2020 Jan 14.

Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.

To distinguish keratoacanthomas from squamous cell carcinomas remains a diagnostic challenge in dermatopathology. Several immunohistochemical and cytogenetic markers have been evaluated; however, so far there has been no unequivocal evidence supporting practical application of any of these markers. Recent studies have evaluated the composition of tumor-associated immune infiltrate, in particular the number and distribution of CD123-positive plasmacytoid dendritic cells in making this distinction; but these cells also do not appear to be a consistent biomarker in distinguishing keratoacanthoma from squamous cell carcinoma. Read More

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http://dx.doi.org/10.1111/cup.13640DOI Listing
April 2020
1.560 Impact Factor

[Did Galileo have a dermal nevus or a keratoacanthoma?]

Authors:
N Kluger

Ann Dermatol Venereol 2020 Jan 13;147(1):74-75. Epub 2019 Dec 13.

Department of dermatology, allergology and venereology, Helsinki University Central Hospital, Helsinki, Finlande; Société française des sciences humaines sur la peau (SFSHP), maison de la dermatologie, 10, cité Malesherbes, 75009 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.annder.2019.09.599DOI Listing
January 2020

Pseudocarcinomatous Hyperplasia, Squamous Cell Carcinoma, and Keratoacanthoma Associated to Lymphomas of the Skin and External Mucous Membranes: A Case Report and Literature Review.

Am J Dermatopathol 2019 Dec 11. Epub 2019 Dec 11.

Departments of Dermatology and Pathology, Hospital Federal de Bonsucesso, Rio de Janeiro, Rio de Janeiro, Brazil.

Pseudocarcinomatous hyperplasia (PCH) is a benign reactive epithelial proliferation that may be associated to lymphomas of the skin or external mucous membranes. We present a case of single lesion mycosis fungoides (Woringer-Kollop's reticulosis pagetoid) associated with PCH that was initially misdiagnosed as squamous cell carcinoma (SCC) and review all PubMed-indexed previously reported cases on lymphomas of the skin or external mucous membranes associated to PCH, SCC, and keratoacanthomas. Including our own case, we collected data of 114 cases of cutaneous or mucosal lymphoproliferative disorders associated to PCH, 3 cases associated to SCC, and other 3 cases associated to keratoacanthomas. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001587DOI Listing
December 2019
5 Reads

Cryosurgery, Intralesional Methotrexate and Imiquimod for Keratoacanthoma: Tuning the Combination.

Case Rep Dermatol Med 2019 11;2019:3489748. Epub 2019 Nov 11.

Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Keratoacanthomas (KA) are self-regressing, destructively expanding keratinocyte skin neoplasms typically characterized by sudden onset of explosive growth followed by complete involution. Cryosurgery, intralesional methotrexate and imiquimod have been used alone or in combination of two for the treatment of KA. Presently 3 patients (49, 60, and 65 years old; two females, one suspected with Ferguson-Smith syndrome), with 5 KA (6-24 mm maximal diameter) were treated with the combination of cryosurgery (liquid N, open spray, 2 cycles of 15 sec each) and intralesional methotrexate (2. Read More

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http://dx.doi.org/10.1155/2019/3489748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877974PMC
November 2019

Recurrent malignant peripheral nerve sheath tumor as a friable nodule within a scar.

Clin Case Rep 2019 Nov 13;7(11):2019-2021. Epub 2019 Sep 13.

Department of Dermatology San Antonio Uniformed Services Health Education Consortium (SAUSHEC) San Antonio Texas.

This case enforces the importance of a patient's medical history in assisting with the diagnosis of nonspecific cutaneous lesions. Also, other types of lesions occurring within a scar are reviewed. Read More

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http://dx.doi.org/10.1002/ccr3.2179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878082PMC
November 2019

Giant Squamous Cell Papilloma of the Eyelid-Diagnostic and Therapeutic Challenges.

Case Rep Ophthalmol Med 2019 29;2019:5830493. Epub 2019 Oct 29.

Department of Ophthalmology, University of Szeged, Szeged, Hungary.

Squamous cell papilloma (SCP) is generally a human papillomavirus (HPV) induced exophytic or endophytic proliferation on the surface of the skin, oral cavity, larynx, esophagus, cervix, vagina, and anal canal. The endophytic type SCP can cause differential diagnostic difficulties with keratoacanthoma, inverted follicular keratosis, and squamous cell carcinoma; however, these lesions are not associated with HPV infection. The authors present a female patient who noticed an extremely rapidly growing tumor destructing the left lower eyelid. Read More

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http://dx.doi.org/10.1155/2019/5830493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875255PMC
October 2019

Multiple keratoacanthomas arising within red tattoo pigment.

Cutis 2019 Oct;104(4):E15-E17

Department of Dermatology, Columbia University Irving Medical Center, USA.

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October 2019

Conjunctival keratoacanthoma/keratoacanthoma like squamous cell carcinoma: Err on the side of caution.

Indian J Ophthalmol 2019 12;67(12):2044-2045

Kanupriya Dalmia Ophthalmic Pathology Laboratory, Mithu Tulsi Chanrai Campus, LV Prasad Eye Institute, Bhubaneswar, India.

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http://dx.doi.org/10.4103/ijo.IJO_314_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896558PMC
December 2019

Keratoacanthoma-like nodules as first manifestation of metastatic epithelioid trophoblastic tumor.

Dermatol Online J 2019 Oct 15;25(10). Epub 2019 Oct 15.

Department of Dermatology, Hospital de Santarém EPE, Santarém.

Cutaneous metastases are rarely the initial manifestation of a previously undiagnosed malignancy and keratoacanthoma-like lesions are a notoriously unusual presentation pattern of cutaneous dissemination of a primary tumor. Herein, we report a 40-year-old woman presenting to our dermatology department with multiple keratoacanthoma-like scalp nodules. Subsequent investigation determined it to be the first manifestation of a disseminated endometrial epithelioid trophoblastic tumor, eventually causing the patient's death. Read More

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October 2019

Differential expression of nicotinamide N-methyltransferase in cutaneous keratoacanthoma and squamous cell carcinoma: an immunohistochemical study.

J Eur Acad Dermatol Venereol 2020 03 28;34(3):e121-e123. Epub 2019 Nov 28.

Department of Clinical Sciences, Marche Polytechnic University, Ancona, Italy.

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http://dx.doi.org/10.1111/jdv.16048DOI Listing

Myriad facades of keratocanthoma: Benignity VS malignancy.

J Oral Biol Craniofac Res 2019 Oct-Dec;9(4):352-354. Epub 2019 Sep 19.

Dept of Oral Pathology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.

Keratoacanthoma (KA) is a self-limiting benign epithelial neoplasm. It occurs predominantly on sun-exposed areas of the body and is believed to arise from hair follicle. It shows a unique behavior in being clinically benign and microscopically malignant. Read More

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http://dx.doi.org/10.1016/j.jobcr.2019.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812000PMC
September 2019

The role of p53, Ki-67 and laminin expression in the differential diagnosis of keratoacanthoma and well-differentiated SCC.

Indian J Pathol Microbiol 2019 Oct-Dec;62(4):561-565

Department of Pathology, Adana Numune Training and Research Hospital, Health Science University, Adana, Turkey.

Introduction: We have aimed to evaluate the difference between the expression of p53, Ki-67, and laminin in keratoacanthoma and well-differentiated SCC (SCC) and to determine its importance in differential diagnosis.

Methods: This study totally included 46 cases consisting of 23 cases with keratoacanthoma and 23 with SCC. As well as age, gender, localization, and diameter of the lesion, the expression of p53, Ki-67 and laminin was evaluated. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_752_18DOI Listing
February 2020
1 Read

From Editor's desk.

Authors:
Ranjan Agrawal

Indian J Pathol Microbiol 2019 Oct-Dec;62(4):521-522

MD; FIC Path; MIAC, DHA, Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/0377-4929.269091DOI Listing

Keratoacanthoma occurring in a recent skin tattoo and self-involuted after a punch biopsy.

G Ital Dermatol Venereol 2019 Sep 30. Epub 2019 Sep 30.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.23736/S0392-0488.19.06407-1DOI Listing
September 2019
2 Reads

Relative Efficacy of Nonoperative Treatment of Keratoacanthomas.

J Cutan Med Surg 2020 Jan/Feb;24(1):41-46. Epub 2019 Oct 8.

21638 Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas, USA.

Background: Keratoacanthomas (KAs) are neoplasms of squamous epithelium which exhibit rapid growth and are often difficult to distinguish clinically from squamous cell carcinoma. Excision is the most common treatment, but in refractory cases or for KAs in cosmetically sensitive areas, nonoperative modalities may be better suited.

Objective: To compare efficacies of topical and intralesional therapies for the treatment of KAs. Read More

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http://dx.doi.org/10.1177/1203475419882336DOI Listing
October 2019
1 Read
0.714 Impact Factor

Pembrolizumab-induced pseudoepitheliomatous eruption consistent with hypertrophic lichen planus.

J Cutan Pathol 2020 Mar 20;47(3):275-279. Epub 2019 Oct 20.

Department of Pathology and Dermatology, Tulane University, New Orleans, Louisiana.

Pembrolizumab, an anti-programmed cell death-1 (PD-1) antibody preparation, has been shown to induce various dermatologic adverse events which may present with delayed onset or even after discontinuation of therapy. We report a 78-year-old female patient with a stage II lung adenocarcinoma treated with pembrolizumab, who developed lichenoid eruptions and multiple cutaneous plaque/nodular eruptions as pseudoepitheliomatous hyperplasia, during and up to 2 months after discontinuation of pembrolizumab therapy. Multiple skin biopsies revealed epidermal hyperplasia with hyperkeratosis, hypergranulosis, diffuse to patchy lichenoid lymphocyte infiltrate with scattered eosinophils and neutrophils, confluent to scant dyskeratosis of the lower epidermis, minimal to overt invagination, and cystic proliferation of squamous epithelium to papillomatosis with hypergranulosis and keratosis. Read More

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http://dx.doi.org/10.1111/cup.13587DOI Listing
March 2020
2 Reads

Cutaneous keratinocyte cancers of the head and neck: Epidemiology, risk factors and clinical, dermoscopic and reflectance confocal microscopic features.

Oral Oncol 2019 11 1;98:109-117. Epub 2019 Oct 1.

Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Brisbane, Australia; Department of Dermatology, Princess Alexandra Hospital, Brisbane, Australia. Electronic address:

Keratinocyte cancers are the most common malignancy among people with European ancestry, and are very common on sun-exposed areas of the head and neck. Incidence is directly correlated with latitude and annual ultraviolet radiation incidence, although there are a number of other environmental, occupational and genetic risk factors, and keratinocyte cancers become more common at middle age. Basal cell carcinomas (BCC) are the most common, comprising 80% of keratinocyte cancers, but have a very low rate of metastases and low mortality. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.09.019DOI Listing
November 2019
1 Read

Tattooist-Associated Tattoo Complications: "Overworked Tattoo," "Pigment Overload" and Infections Producing Early and Late Adverse Events.

Dermatology 2020 9;236(3):208-215. Epub 2019 Sep 9.

"Tattoo Clinic," Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.

Background: Tattooist-related technical failures of tattooing were hitherto unstudied and related to clinical complications. Tattooing requires talent, training and experience. Amateurism is a challenge in popular tattoo industry with no formal education and certification of the tattooists. Read More

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http://dx.doi.org/10.1159/000501962DOI Listing
September 2019
5 Reads

Plasmacytoid dendritic cells in keratoacanthoma and squamous cell carcinoma: A blinded study of CD123 as a diagnostic marker.

J Cutan Pathol 2020 Jan 1;47(1):17-21. Epub 2019 Sep 1.

Department of Internal Medicine, Scripps Mercy Hospital, San Diego, California.

Background: Histopathologic distinction between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is challenging. We surmised that a discriminatory immunostain would be clinically meaningful. Previous investigators have found CD123-positive plasmacytoid dendritic cells (PDCs) are more prominent in KA than SCC. Read More

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http://dx.doi.org/10.1111/cup.13573DOI Listing
January 2020
2 Reads

Multiple Keratoacanthoma-like Lesions in a Patient Treated with Pembrolizumab.

Acta Derm Venereol 2019 Dec;99(13):1301-1302

Department of Dermatology, Paul-Sabatier Toulouse III University; IUCT-oncopole and CHU de Toulouse, 31059 Toulouse, France.

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http://dx.doi.org/10.2340/00015555-3301DOI Listing
December 2019
2 Reads

Bilobed Flap for Reconstruction of a Large Keratoacanthoma of the Thumb.

Case Reports Plast Surg Hand Surg 2019 5;6(1):86-87. Epub 2019 Jul 5.

Tonya Vocatıonal School Health Care Servıces, Karadeniz Technical University, Trabzon, Turkey.

We present the bilobed flap principle which can be used to reconstruct of large defects located on the dorsum of the thumb. The flap provides similar texture, colour and thickness as adjacent hand skin. The final results were excellent both functionally and cosmetically. Read More

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http://dx.doi.org/10.1080/23320885.2019.1634477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691758PMC
July 2019
1 Read

Efficacy of methotrexate as anti-inflammatory and anti-proliferative drug in dermatology: Three case reports.

Exp Ther Med 2019 Aug 19;18(2):905-910. Epub 2019 Apr 19.

Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Methotrexate (MTX) is a folic acid analog with anti-proliferative (anti-neoplastic, cytotoxic), immunosuppressive and anti-inflammatory properties, which has been used in the treatment of various cutaneous disorders, such as psoriasis, keratoacanthoma, pityriasis rubra pilaris, atopic dermatitis, mycosis fungoides, bullous skin diseases, systemic sclerosis, morphea, lupus erythematosus, dermatomyositis and crusted scabies. Inhibition of cell proliferation is explained through its role in blocking DNA/RNA synthesis, by inhibiting dihydrofolate reductase, necessary for the production of pyrimidine and purine nucleotides. An anticancer effect can be related to α-oxoaldehyde metabolism (MTX increases methylglyoxal levels). Read More

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http://dx.doi.org/10.3892/etm.2019.7511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639959PMC
August 2019
12 Reads

Comment on `The detection rate of human papillomavirus in well-differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma?' - reply from authors.

Br J Dermatol 2019 Dec 15;181(6):1345-1346. Epub 2019 Oct 15.

Dermatology Clinic, Maggiore Hospital, Piazza dell'Ospitale 1, University of Trieste, Trieste, Italy.

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http://dx.doi.org/10.1111/bjd.18385DOI Listing
December 2019
12 Reads

Comment on 'The detection rate of human papillomavirus in well-differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma?'

Br J Dermatol 2019 Dec 26;181(6):1343-1345. Epub 2019 Sep 26.

Department of Pathology, Amsterdam University Medical Centres, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/bjd.18383DOI Listing
December 2019
3 Reads

Proliferative Actinic Keratosis: An Invasive Squamous Cell Carcinoma or not?

Acta Dermatovenerol Croat 2019 Jun;27(2):75-80

Muge Gore Karaali, MD, Istanbul Training and Research Hospital , Department of Dermatology, Kasap İlyas Mah. Org. Abdurrahman , Nafiz Gürman Cd., PK: 34098, Istanbul, Turkey;

Actinic keratoses have variants that differ clinically and pathologically. Proliferative actinic keratoses (PAK) are known to be resistant against standard therapies and to create a tendency for the development of invasive squamous cell carcinoma (SCC). This study retrospectively reviewed the medical records of 50 patients with 51 PAK lesions. Read More

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June 2019
6 Reads

Keratoacanthoma arising within a linear epidermal nevus.

Indian J Dermatol Venereol Leprol 2019 Jul 26. Epub 2019 Jul 26.

Department of Dermatology, Charles Nicolle Hospital, University of Tunis El Manar, Tunis, Tunisia.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_842_18DOI Listing
July 2019
2 Reads

Treatment of Solitary Keratoacanthoma of the Nose With Intralesional Methotrexate and Review of the Literature

J Drugs Dermatol 2019 Jul;18(7):693-696

Keratoacathoma (KA) is a unique clinical pathological entity that is difficult to categorize. Differentiating a KA from a squamous cell carcinoma (SCC) is important for treatment implications but is often challenging. We report a patient with a solitary KA of the skin of the right ala successfully treated with intralesional (IL) injections of methotrexate (MTX). Read More

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July 2019
3 Reads

Spontaneous regression of conjunctival keratoacanthoma.

BMJ Case Rep 2019 Jul 11;12(7). Epub 2019 Jul 11.

Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.

An 83-year-old white man presented with a rapidly growing conjunctival mass in his left eye over the course of 1 month. While awaiting surgical intervention, the tumour underwent partial, spontaneous regression to half its original size. The lesion was ultimately excised with wide margins using a no-touch technique and application of cryotherapy to the corneal and conjunctival margins and scleral bed. Read More

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http://dx.doi.org/10.1136/bcr-2018-228833DOI Listing
July 2019
4 Reads

CT and MRI features of scalp lesions.

Radiol Med 2019 Oct 3;124(10):1049-1061. Epub 2019 Jul 3.

Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Scalp lesions can be classified as congenital, traumatic, inflammatory, or neoplastic in origin. Although patients presenting with scalp masses are frequently seen in daily practice, differentiation of scalp lesions is often challenging for radiologists who are not familiar with the imaging of cutaneous lesions. The majority of scalp lesions are fortunately benign, with cystic lesions accounting for over 50% of all benign scalp lesions. Read More

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http://dx.doi.org/10.1007/s11547-019-01060-6DOI Listing
October 2019
8 Reads

Dermatopathological characteristics of dermatofibromas from dermatoscopic clues.

Int J Dermatol 2020 Jan 1;59(1):66-75. Epub 2019 Jul 1.

Department of Dermatology, Ankara University School of Medicine, Ankara, Turkey.

Background: Several types of dermatofibroma (DF) have been identified dermatopathologically and with dermatoscopic correlation, the dermatopathology has been predictable in limited studies so far. We identify DFs with specific dermatoscopic structures and determine the respective dermatopathological correlates.

Methods: Dermatoscopic and dermatopathologic correlation of 403 DFs were assessed. Read More

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http://dx.doi.org/10.1111/ijd.14559DOI Listing
January 2020
7 Reads
1.227 Impact Factor