2,430 results match your criteria Keratoacanthoma

Radiographic features of subungual keratoacanthomas in dogs.

Vet Radiol Ultrasound 2022 May 16. Epub 2022 May 16.

Department of Diagnostic Imaging, Schwarzman Animal Medical Center, New York, NY, 10065, USA.

Subungual keratoacanthoma (SK) is a digital neoplasm that has rarely been reported in dogs and carries an excellent prognosis following surgical removal. Radiographic features of canine SK have only been briefly discussed in two prior case reports. Both articles described extensive distal phalangeal osteolysis, a feature more commonly associated with malignant digital neoplasms (e. Read More

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Extraordinarily aggressive cutaneous sarcomatoid squamous cell carcinoma of the face: a case report.

Arch Craniofac Surg 2022 Apr 20;23(2):77-82. Epub 2022 Apr 20.

Department of Plastic and Reconstructive Surgery, Daegu Fatima Hospital, Daegu, Korea.

Sarcomatoid squamous cell carcinoma (SSCC), a biphasic malignant tumor consisting of atypical squamous epithelial and mesenchymal elements mixed with epithelioid and spindle cells, is a variant of squamous cell carcinoma. Cutaneous SSCC is very rare and aggressive and has a poor prognosis. Here, we report a case of cutaneous SSCC with satellites and in-transit metastases. Read More

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Large Crateriform Molluscum on Penis Masquerading as Keratoacanthoma.

J Glob Infect Dis 2022 Jan-Mar;14(1):41-42. Epub 2022 Feb 16.

Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

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February 2022

Not all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling.

J Am Acad Dermatol 2022 Apr 6. Epub 2022 Apr 6.

Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis.

Front Oncol 2022 22;12:868781. Epub 2022 Mar 22.

Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, China.

The prevalence of Merkel cell polyomavirus(MCPyV) in Merkel cell carcinoma(MCC) and non-MCC skin lesions and its possible role in the etiology of other skin diseases remain controversial. To systematically assess the association between MCPyV infection and MCC, non-MCC skin lesions, and normal skin. For this systematic review and meta-analysis, a comprehensive search for eligible studies was conducted using Medline Ovid, Pubmed, Web of Science, and the Cochrane CENTRAL databases until August 2021; references were searched to identify additional studies. Read More

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Radiographic characteristics of canine subungual keratoacanthoma.

Vet Radiol Ultrasound 2022 Mar 29. Epub 2022 Mar 29.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, Indiana, USA.

Subungual keratoacanthoma (SKA) is a rare benign nail bed tumor in dogs, and its radiographic characteristics have not been reported based on the authors' review of the literature. The purpose of this multicenter, retrospective, observational, descriptive study was to describe the radiographic features of SKA in dogs. Twelve dogs for a total of 12 digits with histologically confirmed SKA met the inclusion criteria. Read More

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Multiple eruptive squamoproliferative lesions during anti-PD1 immunotherapy for metastatic melanoma: Pathogenesis, immunohistochemical analysis and treatment.

Dermatol Ther 2022 Mar 29:e15472. Epub 2022 Mar 29.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.

Treatment with anti-PD1 inhibitors may enhance the risk for developing low grade squamoproliferative skin tumors. Immunohistochemical (IHC) analysis of the immune tumor microenvironment (TME) allows exploration of the pathogenesis and relationship with the PD1/PDL1 axis. Patients with eruptive keratoacanthoma (KA)-like lesions were recruited from the Melanoma Institute Australia, a tertiary referral specialist melanoma treatment center from January 2015 to August 2017. Read More

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Giant Keratoacanthoma of the Hand.

J Cutan Med Surg 2022 Mar 23:12034754221088564. Epub 2022 Mar 23.

37895 Department of Dermatology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

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Self-involution of a Solitary Keratoacanthoma: A Case Report with Photographic Documentation.

J Cutan Aesthet Surg 2021 Oct-Dec;14(4):433-435

Clinical Oncology Institute, Arturo López Pérez Foundation, Santiago, Chile.

Keratoacanthoma (KA) is a common and distinctive cutaneous neoplasm that behaves in a benign fashion, displaying rapid growth followed by spontaneous involution. Clinical and histological examinations are essential to confirm this diagnosis, although differentiating KA from squamous cell carcinoma is often difficult. In general, complete surgical excision is a standard of care for solitary KAs; however, the conservative approach could be considered in some selected situations. Read More

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Squamous Cell Carcinoma and Tattoo: A Man With a Tattoo-Associated Squamous Cell Carcinoma and Review of Benign Tumors, Lymphoid Conditions, and Malignant Neoplasms Occurring Within a Tattoo.

Philip R Cohen

Cureus 2022 Jan 10;14(1):e21083. Epub 2022 Jan 10.

Dermatology, University of California, Davis Medical Center, Sacramento, USA.

Tattoos, a common form of body adornment, have been associated with numerous cutaneous complications. These include not only benign neoplasms and malignant tumors but also lymphoid conditions occurring within the tattoo. Tattoo-associated dermatomyofibroma, epidermoid inclusion cyst, hemangioma, lipoma, milia, and pilomatricoma are benign lesions that have each only been described in one individual. Read More

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January 2022

A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa.

JAAD Case Rep 2022 Mar 10;21:49-51. Epub 2022 Jan 10.

Dermatology Service, San Francisco VA Health Care System, San Francisco, California.

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Development and validation of a HPLC-UV based method for the extraction and quantification of methotrexate in the skin.

Biomed Chromatogr 2022 May 9;36(5):e5349. Epub 2022 Feb 9.

Department of Food and Drug, University of Parma, Parma, Italy.

An innovative and sensitive HPLC-UV method for the extraction and quantification of methotrexate (MTX) in skin layers was developed and validated. Owing to the physico-chemical characteristics of the drug and the nature of the tissue, it was necessary to use folic acid (FA) as an internal standard for MTX quantification in the dermis. MTX (and FA) analysis was performed on a Phenomenex Jupiter C column, using a 50 mm sodium acetate buffer (pH 3. Read More

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Intravascular Basal Cell Carcinoma Hiding under a Keratoacanthoma.

Case Rep Dermatol 2021 Sep-Dec;13(3):537-541. Epub 2021 Nov 29.

Glick Skin Institute, Margate, Florida, USA.

A 79-year-old male presented for removal of what was proven to be a keratoacanthoma. Additional tissue removed deep to the initial lesion revealed intravascular basal cell carcinoma (BCC). Intravascular BCC is exceedingly rare with only 8 cases previously reported in the literature. Read More

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November 2021

Cutaneous leishmaniasis over a tattoo mimicking keratoacanthoma in Southern Europe.

J Eur Acad Dermatol Venereol 2022 05 25;36(5):e387-e389. Epub 2022 Jan 25.

Department of Contact Eczema and Immunoallergic Diseases, Dermatology, Hospital Universitario San Cecilio, Granada, Spain.

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Clinical, histopathological and immunohistochemical study of keratoacanthoma.

Rom J Morphol Embryol 2021 Apr-Jun;62(2):445-456

Department of Dermatology, University of Medicine and Pharmacy of Craiova, Romania; e-mail:

Keratoacanthoma (KA) is an epithelial tumor of the skin, classically considered as having a malignant transformation risk of 15%; however, many authors and the new World Health Organization (WHO) Classification of skin tumors consider KA as an incipient variant of the cutaneous squamous cell carcinoma (SCC). The aims of the study were to assess the clinical, histopathological (HP) and immunohistochemical (IHC) aspects of the KA and the role of these factors in malignancy occurrence. The studied group comprises 194 patients diagnosed with KA or malignant KA, hospitalized in the Clinic of Dermatology, Emergency County Hospital, Craiova, Romania, between 2006 and 2019. Read More

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January 2022

Cutaneous Horn Revisited: A Woman With a Verruca Vulgaris-Associated Cornu Cutaneum.

Cureus 2021 Nov 26;13(11):e19925. Epub 2021 Nov 26.

Dermatology, University of California Davis Medical Center, Sacramento, USA.

A cutaneous horn, sometimes referred to as cornu cutaneum, is a projection arising on the skin due to an overgrowth of the epidermal stratum corneum. This lesion is a clinical presentation of an underlying skin tumor. A woman with a verruca vulgaris-associated cutaneous horn is described. Read More

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November 2021

Dermoscopy of inflamed seborrheic keratosis: A great mimic of malignancy.

Australas J Dermatol 2022 Feb 27;63(1):53-61. Epub 2021 Dec 27.

Department of Dermatology, Hospital de Sant Pau i Santa Tecla, Tarragona, Spain.

Background: Clinical and dermoscopic recognition of seborrheic keratoses (SKs) is often straightforward, and biopsy might not be required. However, inflamed SKs (iSKs) can pose a diagnostic challenge. Dermoscopic features of iSKs have not yet been evaluated to date. Read More

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February 2022

Clinical utility of intralesional methotrexate to distinguish crateriform keratinocytic tumors before surgery.

J Dtsch Dermatol Ges 2022 01 21;20(1):102-105. Epub 2021 Dec 21.

Department of Dermatology, University Clinic of Navarra, School of Medicine, University of Navarra, Pamplona, Spain.

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January 2022

Keratoacanthoma or cutaneous squamous cell carcinoma revealing a DNA mismatch repair default (Muir-Torre Syndrome).

J Eur Acad Dermatol Venereol 2022 Jan;36 Suppl 1:74-76

Dermatology Service, Department of Medicine, Gustave Roussy, Villejuif, France.

Keratoacanthoma (KA) and well-differentiated cutaneous squamous cell carcinoma (cSCC) are hardly distinguishable clinically and histologically. They both can be seen in patients with hereditary non-polyposis colorectal cancer (HNPCC) or Lynch Syndrome, corresponding to DNA microsatellite instability. In our case, a young man had the excision of two rapidly growing skin tumours for which distinction between KA and cSCC was initially clinically and pathologically challenging. Read More

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January 2022

[Repair of eyelid and periocular soft tissue defects with Pacman flap].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Nov;35(11):1463-1466

Department of Plastic and Reconstructive Surgery, Peking University People's Hospital, Beijing, 100044, P.R.China.

Objective: To explore the effectiveness and safety of Pacman flap for repair of eyelid and periocular soft tissue defects.

Methods: The clinical data of 12 patients who underwent repair of eyelid and periocular soft tissue defects with Pacman flap between April 2015 and September 2020 was retrospectively reviewed. There were 5 males and 7 females, aged from 18 to 87 years, with a median age of 63 years. Read More

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November 2021

Successful treatment of a keratoacanthoma in a young patient with the application of topical 5% imiquimod cream.

Clin Case Rep 2021 Nov 6;9(11):e04920. Epub 2021 Nov 6.

Department of Dermatology General University Hospital of Patras Patras Greece.

Keratoacanthomas (KA) are epithelial tumors that present as rapidly evolving nodules with a central hyperkeratotic plug and occasionally show signs of spontaneous regression. A 21-year-old patient strongly refused the diagnostic biopsy and insisted on a nonsurgical treatment. He was successfully treated with imiquimod 5% cream. Read More

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November 2021

Clinical and Histopathological Characteristics of Tumors Arising in Seborrheic Keratosis: A Study of 1365 Cases.

Ther Clin Risk Manag 2021 27;17:1135-1143. Epub 2021 Oct 27.

Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.

Objective: The aim of this study was to describe the clinical and histopathological characteristics of seborrheic keratosis (SK) with secondary tumor and identify associated factors.

Methods: This study was a monocentric retrospective case-control study describing the factors associated with the development of tumors in SK. A total of 1365 patients with SK were admitted to our department between 2018 and 2021. Read More

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October 2021

Skin Deep: A Fascinating Case Report of Immunotherapy-Triggered, Treatment-Refractory Autoimmune Lichen Planus and Keratoacanthoma.

Case Rep Oncol 2021 May-Aug;14(2):1189-1193. Epub 2021 Aug 16.

Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

This case discusses a 62-year-old woman with de novo metastatic lung adenocarcinoma (PD-L1 >50% with a KRAS G12C mutation, ALK and EGFR negative) who was on pembrolizumab for 1 year without any significant toxicity, only low-grade dermatitis and hypothyroidism. She was transitioned to pembrolizumab every 6 weeks at 4 mg/kg and began to develop oral sores shortly thereafter. The sores proved refractory to nystatin and mouth rinses containing corticosteroids, and the patient was ultimately diagnosed with autoimmune-triggered lichen planus. Read More

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Response to 'A clinical and biological review of keratoacanthoma': reply from authors.

Br J Dermatol 2022 03 22;186(3):592-593. Epub 2021 Dec 22.

Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.

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Considerations in the management of keratoacanthoma.

D Mazzoni J Muir

Br J Dermatol 2022 03 30;186(3):592. Epub 2021 Nov 30.

Mater Hospital, Brisbane, QLD, Australia.

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A Review of Immunocryosurgery and a Practical Guide to Its Applications.

Diseases 2021 Oct 14;9(4). Epub 2021 Oct 14.

Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.

Immunocryosurgery is a minimally invasive combinational therapeutic procedure that has been designed, developed, and evaluated in the Dermatology Department of the University of Ioannina from 2004. In a fixed time protocol, this approach combines immune stimulatory therapy with imiquimod and cryosurgery, i.e. Read More

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October 2021

What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell Carcinoma.

Diagnostics (Basel) 2021 Oct 7;11(10). Epub 2021 Oct 7.

Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki 211-8533, Japan.

We present histopathological criteria for diagnosing keratoacanthoma (KA). In KA, four histological stages are recognized, which are the early/proliferative stage, well-developed stage, regressing stage and regressed stage. In diagnosing KA, we emphasize that KA consists of the proliferation of enlarged pale pink cells with ground glass-like cytoplasm without nuclear atypia, other than crateriform architecture. Read More

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October 2021

Spironolactone-Induced Lichenoid Drug Reaction and Subsequent Diffuse Eruptive Squamous Cell Carcinomas Successfully Treated With Systemic Methotrexate.

Cureus 2021 Sep 4;13(9):e17713. Epub 2021 Sep 4.

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.

Antihypertensive agents such as spironolactone have been reported to cause lichenoid drug eruptions. Eruptive keratoacanthomas (KA), considered to be well-differentiated squamous cell carcinoma (SCC), may develop in the setting of such lichenoid reactions. Thus, definitive treatment is imperative. Read More

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September 2021