2,368 results match your criteria Keratoacanthoma

Papillary Renal Cell Carcinoma in Lynch/Muir-Torre Syndrome with Germline Pathogenic Variant in and Molecular Analysis: Report of a Case and Review of the Literature.

J Kidney Cancer VHL 2021 21;8(2):8-19. Epub 2021 Apr 21.

Department of Pathology & Immunology.

Lynch syndrome (LS) is an autosomal dominant inherited disorder due to pathogenic variations in the mismatch repair genes, which predisposes to malignancies, most commonly colon and endometrial carcinoma. Muir-Torre syndrome is a subset of LS with cutaneous sebaceous adenoma and keratoacanthoma in addition to the malignancies. Renal cell carcinoma (RCC) in patients with LS is extremely rare. Read More

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Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia.

Acta Derm Venereol 2021 May 6. Epub 2021 May 6.

Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Keratoacanthomas are common keratinocyte skin tumours. However, there is little community-based data on the patient and tumour characteristics of keratoacanthoma. The aim of this study was to investigate this subject using data from the QSkin study, a prospective cohort of 40,438 randomly sampled and consented participants aged 40-69 years in Queensland, Australia. Read More

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Dermoscopy as a Tool in Differentiating Cutaneous Squamous Cell Carcinoma From Its Variants.

Dermatol Pract Concept 2021 Mar 12;11(2):e2021050. Epub 2021 Apr 12.

Second Department of Dermatology & Venereology, Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Background: Dermoscopic features of cutaneous squamous cell carcinoma (cSCC) have been widely studied, but their accuracy should be further investigated.

Objectives: This study assessed the diagnostic accuracy of a set of predetermined dermoscopic structures for 3 variants of cSCC, namely Bowen disease, keratoacanthoma and invasive cSCC.

Methods: Dermoscopic images of 56 histopathologically confirmed cSCC lesions (9 Bowen disease lesions, 7 keratoacanthomas, and 40 invasive cSCCs) were examined, and the diagnostic accuracy of dermoscopic structures was assessed. Read More

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Actinic Granuloma of the Conjunctiva: Case series and review of the literature.

Am J Ophthalmol 2021 Apr 22. Epub 2021 Apr 22.

Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

Purpose: To report the clinical and histopathological features of actinic granuloma of the conjunctiva.

Design: Retrospective observational case series.

Methods: Institutional pathology records between 2014 and 2020 were searched for all cases of conjunctival actinic granuloma. Read More

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Clinical profile of cutaneous adverse events of immune checkpoint inhibitors in a single tertiary center.

J Dermatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors have demonstrated their efficacy in the treatment of various malignancies. Despite their benefits, their immunomodulatory activities can cause unpredictable cutaneous adverse events (CAE). This study aimed to identify characteristics of CAE in patients treated with PD-1/PD-L1 inhibitors through the medical records, photographs, and pathology reports. Read More

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Keratoacanthoma centrifugum marginatum.

Dermatol Online J 2021 Mar 15;27(3). Epub 2021 Mar 15.

Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN.

Keratoacanthoma centrifugum marginatum (KCM) is an uncommon variant of keratoacanthoma. Keratoacanthoma centrifugum marginatums are most commonly seen on sun-exposed surfaces and present with progressive peripheral expansion and raised, hyperkeratotic borders. Central clearing with atrophy and lack of spontaneous clearance are other key clinical characteristics. Read More

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A Clinical and Biologic Review of Keratoacanthoma.

Br J Dermatol 2021 Apr 16. Epub 2021 Apr 16.

Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.

Keratoacanthoma (KA) is a common skin tumor that remains controversial regarding classification, epidemiology, diagnosis, prognosis, and management. Classically, a KA manifests as a rapidly growing, well-differentiated, squamoid lesion with a predilection for sun-exposed sites in the elderly and a tendency to spontaneously regress. Historically, KAs have been considered a variant of cutaneous squamous cell carcinoma (cSCC) and are often reported as KA-type cSCC. Read More

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Evaluation of relationship between antihypertensive drug usage and dermatoscopic features in patients with keratinizing skin cancer.

Dermatol Ther 2021 Apr 11:e14957. Epub 2021 Apr 11.

Department of Dermatology, Health Science University, Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Keratinizing skin cancers including actinic keratoses (AK), in situ squamous cell carcinoma/Bowen's disease/intraepidermal carcinoma (IEC), invasive cutaneous squamous cell carcinoma (cSCC) and keratoacanthoma share similar dermatoscopic features and also reveal different patterns that assist in their diagnosis. Recently epidemiological studies reveal the association between antihypertensive drugs and skin cancer risk, especially cSCC. This study aims to determine the dermatoscopic features of keratinizing skin cancer in patients using antihypertensive drug and compare with non-users. Read More

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Complete cure of a large resistant keratoacanthoma of the eyelid with intralesional methotrexate.

Can J Ophthalmol 2021 Apr 8. Epub 2021 Apr 8.

Ocular Oncology service, Princess Margaret Cancer Centre/UHN, University of Toronto, Toronto, Ontario, Canada.

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Dermoscopic Features of Giant Molluscum Contagiosum in a Patient with Acquired Immunodeficiency Syndrome.

Acta Dermatovenerol Croat 2020 Dec;28(7):233-235

Martyna Sławińska MD, PhD, Department of Dermatology, Venereology and Allergology Medical University of Gdańsk, Smoluchowskiego 17 Street, 80-214 Gdańsk;

Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In contrast to typical molluscum contagiosum, dermoscopic features of giant lesions have been poorly described, and none of the reports included multiple giant lesions in an immunocompromised patient. We present a patient with acquired immunodeficiency syndrome diagnosed with multiple giant molluscum contagiosum along with the dermoscopic features of this entity. Read More

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December 2020

Perianal keratoacanthoma in a 76-year-old man.

ANZ J Surg 2021 Mar 31. Epub 2021 Mar 31.

Department of Dermatopathology, Clinpath Pathology, Adelaide, South Australia, Australia.

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Management of keratoacanthoma with perineural invasion: case reports and literature review.

Australas J Dermatol 2021 Mar 24. Epub 2021 Mar 24.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

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[Cancer-associated genodermatoses].

Hautarzt 2021 Apr 4;72(4):288-294. Epub 2021 Mar 4.

Klinik für Dermatologie und Allergologie, LMU Klinikum, Frauenlobstr. 9-11, 80337, München, Deutschland.

Hereditary tumor syndromes are characterized by a familial occurrence of tumors/cancer. A hereditary tumor syndrome should be suspected if a familial occurrence of cancer is seen and/or persons at younger age are affected. Some of the currently known tumor syndromes are associated with specific skin symptoms that can aid the physician in establishing the correct diagnosis. Read More

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Cutaneous Squamous Cell Carcinoma in Lynch Syndrome - An Overlooked Association.

Cureus 2021 Feb 25;13(2):e13553. Epub 2021 Feb 25.

Internal Medicine, B. J. Medical College, Ahmedabad, IND.

Lynch syndrome is an autosomal dominant disorder caused by germline mutation affecting mismatch-repair genes. Genetic testing is performed selectively. Diagnosed individuals are to undergo surveillance to detect and manage Lynch syndrome-related cancers early in the course. Read More

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February 2021

Grzybowski's Generalized Eruptive Keratoacanthomas in a Patient with Terminal Kidney Disease-An Unmet Medical Need Equally Ameliorated by Topical Imiquimod Cream and Lapacho Tea Wraps: A Case Report.

Dermatol Ther (Heidelb) 2021 Apr 23;11(2):625-638. Epub 2021 Feb 23.

Department of Dermatology and Allergy, University Hospital Bonn, Venusberg Campus 1, 53127, Bonn, Germany.

Introduction: Development of singular keratoacanthoma (KA) is generally considered a benign condition as it has a tendency to regress spontaneously in spite of histological similarity to squamous cell carcinoma. Most KAs undergo excision to rule out differential diagnoses. Several alternative treatment modalities (keratinolytic, ablative, immunomodulating, antiproliferative, or targeted therapy) have been described in the past with varying success, underlining the therapeutic challenges associated with large or multiple lesions. Read More

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Multiple Keratoacanthomas after a Recent Tattoo: A Case Report.

Case Rep Dermatol 2021 Jan-Apr;13(1):23-27. Epub 2021 Jan 25.

Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.

We report on a 39-year-old man who presented with seven skin lesions on the right thigh 3 weeks after receiving a large tattoo which included red and black pigments. Initially, the lesions grew fast, later their growth stabilized. Histopathology showed well-circumscribed symmetric tumors with a central keratin-filled crater along with further trademarks of a keratoacanthoma. Read More

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January 2021

Dermatoscopic findings and dermatopathological correlates in clinical variants of actinic keratosis, Bowen's disease, keratoacanthoma, and squamous cell carcinoma.

Dermatol Ther 2021 Feb 14:e14877. Epub 2021 Feb 14.

Faculty of Medicine, Dermatology Department, Ankara University, Ankara, Turkey.

Non-melanoma skin cancer (NMSC), predominantly squamous cell carcinoma (SCC) and basal cell carcinoma, is increasing worldwide. Dermatoscopy, which is one of the non-invasive diagnostic techniques, is important for early diagnosis of NMSC. In this study we aimed to determine dermatoscopic features of keratinocyte derived tumors including actinic keratosis (AK), Bowen's disease (BD), keratoacanthoma (KA), and SCC and correlate the dermatoscopic findings with pathology. Read More

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February 2021

Skin tumors in xeroderma pigmentosum: Evaluation of a large series and a literature review.

J Cutan Pathol 2021 Feb 11. Epub 2021 Feb 11.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Xeroderma pigmentosum (XP) is a rare genodermatosis with a lifelong propensity to develop malignant skin tumors.

Methods: In this retrospective study, 24 XP patients were evaluated with regard to frequency and clinicopathological features of benign and malignant skin tumors.

Results: Seventeen patients had at least one malignant skin tumor diagnosed: basal cell carcinoma (BCC) in 13 patients (n = 72), basosquamous carcinoma in three patients (n = 4), squamous cell carcinoma in six patients (n = 13), keratoacanthoma in three patients (n = 15), and melanoma in six patients (n = 18). Read More

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February 2021

Intralesional 5-Fluorouracil for Treatment of Non-Melanoma Skin Cancer: A Systematic Review.

J Drugs Dermatol 2021 02;20(2):192-198

Background: Surgical excision is the paradigm treatment option for non-melanoma skin cancer (NMSC), however intralesional fluorouracil (IL 5-FU) is an efficacious alternative and superior to other chemotherapy agents in NMSC. Yet, little summative data exists on the topic.

Objective: To assess the efficacy of IL 5-FU in the treatment of NMSC. Read More

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February 2021

A case of Muir-Torre syndrome with a keratoacanthoma and sebaceous neoplasms: Clinicopathological features and a speculation on the pathogenesis of cutaneous tumor type.

J Dermatol 2021 May 1;48(5):690-694. Epub 2021 Feb 1.

Department of Dermatology, Hyogo Cancer Center, Akashi, Japan.

Muir-Torre syndrome is a hereditary condition characterized by occurrence of sebaceous neoplasms or keratoacanthomas and visceral tumors. The most common mechanism for this syndrome is a constitutional defect in the mismatch repair genes. We report the case of a 67-year-old woman with a mutator L homologue 1 (MLH1) mutation. Read More

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Keratoacanthoma: Update on the Debate.

Am J Dermatopathol 2021 Apr;43(4):305-307

Australasian College of Cutaneous Oncology, Docklands, VIC, Australia.

Abstract: Keratoacanthoma (KA) is a cutaneous tumor with a biphasic pattern of growth. A rapidly growing phase is usually followed by involution. KA occurs on sun-damaged skin. Read More

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Multiple keratoacanthomas in a patient with myelodysplastic syndrome.

Lancet Haematol 2021 01 22;8(1):e94. Epub 2020 Dec 22.

Department of Dermatology and Venereology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China. Electronic address:

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January 2021

Case for diagnosis. A pruritic eruption of keratotic papules over the face and neck.

An Bras Dermatol 2021 Jan-Feb;96(1):100-102. Epub 2020 Nov 18.

Department of Dermatology, Coimbra University Hospital Center, Coimbra, Portugal.

Generalized eruptive keratoacanthoma of Grzybowski is a rare variant of multiple keratoacanthomas counting with about 40 cases reported. It is a chronic and progressive disease for which none of the described therapeutic options has been entirely satisfactory. We report a case of an 83-year-old female who presented with a 3-month history of extremely pruritic, multiple, skin-coloured to erythematous to brownish, millimetric papules, with a keratotic centre. Read More

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February 2021

Sebaceous Tumors of the Skin: A Study of 145 Lesions From 136 Patients Correlating Pathologic Features and DNA Mismatch Repair Staining Pattern.

Am J Dermatopathol 2021 Mar;43(3):174-181

Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.

Abstract: Sebaceous neoplasms occur sporadically or in the setting of Muir-Torre syndrome. The data regarding the correlation of pathologic features and DNA mismatch repair (MMR) staining pattern in sebaceous tumors of the skin are very scanty and based on relatively small series of patients. The goal of this study was to correlate MMR staining pattern with selected morphological features in a series of 145 sebaceous neoplasms (sebaceous adenoma, sebaceoma, and extraocular sebaceous carcinoma) from 136 patients. Read More

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A Case of Giant Proliferative Periocular Pyogenic Granuloma.

Orbit 2020 Nov 12:1-2. Epub 2020 Nov 12.

Department of Plastic Surgery, Queen Elizabeth Hospital, Birmingham, UK.

Pyogenic granuloma (PG) is a common vascular anomaly affecting the skin with occasional involvement of mucosa. Ophthalmic surgeons typically encounter these lesions as solitary, bright red, rapidly growing papules following surgery or trauma to the conjunctiva, e.g. Read More

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November 2020

The Effectiveness of Cryosurgery Combined with Curettage and Electrodessication in the Treatment of Keratoacanthoma: A Retrospective Analysis of 90 Cases.

Indian J Dermatol 2020 Sep-Oct;65(5):406-408

National and Kapodistrian University of Athens, Andreas Syggros Hospital of Cutaneous and Venereal Diseases, Cryosurgery Unit, Athens, Greece.

Background: There are several treatment options for keratoacanthoma (KA). However, there are limited data available on the use of cryosurgery.

Objective: To evaluate the effectiveness and safety of a combination treatment for KA and to evaluate the cosmetic outcome. Read More

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November 2020

Eruptive Keratoacanthomas in a Red Tattoo.

Sultan Qaboos Univ Med J 2020 08 5;20(3):e372-e373. Epub 2020 Oct 5.

Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.

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The first report of diagnosing of keratoacanthoma in Chinese Han patients using dermoscopy and reflectance confocal microscopy.

Skin Res Technol 2020 Oct 24. Epub 2020 Oct 24.

Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: Keratoacanthoma (KA) is a special kind of tumor, which is regarded as a variant of squamous cell carcinoma (SCC) in some academic disciplines. But differentiating KA from SCC remains a diagnostic challenge. The noninvasive techniques dermoscopy and reflectance confocal microscopy (RCM) can provide new insights for diagnosis. Read More

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October 2020

A review of CD30 expression in cutaneous neoplasms.

J Cutan Pathol 2021 Apr 6;48(4):495-510. Epub 2020 Nov 6.

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.

Background: The surface protein CD30 is a therapeutic target of monoclonal antibody therapy. Knowledge of the frequency of CD30 expression and its prognostic relevance is therefore interesting, not only in lymphoproliferative disorders (LPD) but also in solid tumors of the skin.

Methods: A review was completed in PubMed for all published reports of CD30 expression in cutaneous lymphomas, mastocytosis, epithelial tumors and sarcomas from 1982 to April 2019. Read More

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Intralesional methotrexate in dermatology: Diverse indications and practical considerations.

Dermatol Ther 2021 Jan 20;34(1):e14404. Epub 2020 Oct 20.

Department of Dermatology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Intralesional methotrexate (IL-MTX) is a long-established treatment, which is arguably underutilized by dermatologists. We describe the underlying evidence base and practical considerations for its broad range of cutaneous indications, including in cutaneous oncology (keratoacanthomas, squamous cell carcinomas, lymphomas), inflammatory dermatology (nail psoriasis, plaque psoriasis, pyoderma gangrenosum, cutaneous Crohn's disease, amyloidosis), cutaneous infections (viral warts) and for treatment of filler complications. In certain circumstances, IL-MTX can be more efficacious and less invasive than other treatments, with fewer adverse effects. Read More

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January 2021