2,205 results match your criteria Keratoacanthoma
Case Rep Dermatol 2018 Sep-Dec;10(3):247-250. Epub 2018 Nov 14.
Medical Department, Cantabria Labs Difa Cooper, Caronno Pertusella, Italy.
Several case reports and retrospective studies have demonstrated that intralesional methotrexate (MTX) could be a very effective and safe alternative treatment of keratoacanthoma (KA). Here, we report a rapid clinical efficacy of two intralesional MTX injections (total dose 40 mg) that were performed 1 week apart in the treatment of a large KA lesion of the dorsal hand in a 99-year-old woman. The lesion, with a 3-cm major axis diameter and a thickness of 2 cm with a central ulceration had rapidly appeared on the right dorsal hand. Read More
Case Rep Oncol 2018 Sep-Dec;11(3):671-675. Epub 2018 Oct 24.
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Keratoacanthoma centrifugum marignatum (KCM) is a rare variant of keratoacanthoma, which is characterized by the dense infiltration of inflammatory cells throughout the dermis, especially around the keratinocytic islands. Therefore, it is sometimes difficult to differentiate between KCM and cutaneous T-cell lymphomas. In this report, we describe a case of KCM with spontaneous regression that showed dense infiltration of CD3+CD8+ T cells. Read More
Postepy Dermatol Alergol 2018 Oct 19;35(5):535-537. Epub 2018 Jul 19.
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
Cureus 2018 Aug 23;10(8):e3196. Epub 2018 Aug 23.
Dermatologist, San Diego Family Dermatology, San Diego, USA.
Sporotrichosis is a fungal infection known for its distinct pattern of infectious skin nodules. Several conditions can present with lesions that appear in a sporotrichoid pattern. An 82-year-old man that presented with three cutaneous nodules on his right leg in a sporotrichoid manner is described; biopsy of each lesion revealed a keratoacanthoma. Read More
BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.
Department of Dermatology, Medway NHS Foundation Trust, Gillingham, UK.
Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA), characterised by a progressively expanding tumour with a lack of spontaneous remission and significant scarring. KCM has been reported previously in less than 50 cases worldwide. We present the case of a large solitary KCM on the right shin of a 71-year-old woman. Read More
Indian J Dermatol Venereol Leprol 2018 Oct 29. Epub 2018 Oct 29.
Department of Dermatology and Venereology, Goa Medical College, North Goa, Goa, India.
J Dermatol 2018 Oct 24. Epub 2018 Oct 24.
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Clin Exp Dermatol 2018 Oct 2. Epub 2018 Oct 2.
Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Background: Vemurafenib has been linked to dermatological adverse events in patients with melanoma, including an increased risk of rash, cutaneous squamous cell carcinoma, photosensitivity reaction and keratoacanthoma. However, there has been no systematic attempt to assess the dermatological toxicity data of vemurafenib associated with melanoma treatment.
Aim: To evaluate the point prevalence of dermatological toxicities associated with vemurafenib treatment in patients with melanoma. Read More
Pan Afr Med J 2018 5;30:12. Epub 2018 May 5.
Service de Dermatologie Hôpital Militaire d'Instruction Mohamed V, Rabat, Maroc.
We here report the case of a 54-year old woman presenting with a swelling in the left forearm occurred eight weeks before and rapidly increasing in volume. Clinical examination showed ulcero-budding painless purplish skin lesion measuring 2 cm along its longer axis (A). The patient underwent simple biopsy. Read More
J Oral Maxillofac Surg 2018 Jul 30. Epub 2018 Jul 30.
Private Practitioner, Department of Dermatology, Hospital de Clinicas da Universidade Federal do Parana, Curitiba, Brazil.
A 58-year-old woman presented with a 30-day history of a moderately painful enlarging nodule on her upper cutaneous lip. Two weeks prior to presentation, she fell on the sidewalk leading to injuries of the oral mucosa, right temple, and knees. Physical examination revealed a 1. Read More
JAAD Case Rep 2018 Aug 15;4(7):701-704. Epub 2018 Aug 15.
Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas.
Dermatol Pract Concept 2018 Jul 31;8(3):204-207. Epub 2018 Jul 31.
Dermatology Unit, University of Campania, Naples, Italy.
Australas J Dermatol 2018 Aug 15. Epub 2018 Aug 15.
Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Background And Objectives: While dermatoscopy improves diagnostic accuracy for raised nonpigmented lesions, those with white surface keratin can be problematical. We investigated whether retention of povidone-iodine by surface keratin provides a clue to benignity.
Methods: We performed a retrospective pilot study (n = 57) followed by a prospective study (n = 117) on raised nonpigmented lesions with white surface keratin. Read More
Recent Results Cancer Res 2018;211:77-89
Division of Dermatooncology, Department of Dermatology, University Medical Centre, Liebermeisterstr. 25, 72074, Tuebingen, Germany.
The activating BRAF mutation V600E and related mutations in this codon are most important for the activation of the RAS/RAF/MEK/ERK mitogen-activated protein kinase (MAPK) signalling pathway in melanoma. BRAF V600E mutations have been detected in ~40% of melanoma patients and BRAF V600K mutations in ~5% of melanoma patients. Activation of the MAPK pathway results in continuous stimulation of cell proliferation and inhibits programmed cell death. Read More
Dermatol Surg 2018 07;44(7):1028-1030
Marmur Medical, New York, New York Department of Dermatology, University of California, Irvine, Irvine, California Marmur Medical, New York, New York Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
Photodiagnosis Photodyn Ther 2018 09 18;23:151-153. Epub 2018 Jun 18.
Department of Dermatology, Huadong Hospital, Fudan University, Shanghai 200040, PR China. Electronic address:
BMC Public Health 2018 Jun 8;18(1):713. Epub 2018 Jun 8.
Department of Public Health, Mount Kenya University, School of Health Sciences, P. O. Box 5826, Kigali Campus, Kigali, Rwanda.
Background: All over the globe shisha smoking is fast growing among different age brackets. Shisha use has been reported to be increasing among youths in African major cities. Its use is documented to result in health effects such as lung cancer, cardiovascular and respiratory conditions, periodontal diseases, keratoacanthoma which are also associated with cigarette smoking. Read More
Ann Burns Fire Disasters 2017 Sep;30(3):218-219
Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Marjolin's ulcer refers to any malignant transformation of chronic wounds. Different chronic wounds may be transformed into malignancies, although they usually have a latency period of between 25 to 40 years after the primary injury. We herein present an otherwise healthy man who developed squamous cell carcinoma (SCC) three weeks after burn injury. Read More
Cancer Immunol Immunother 2018 07 24;67(7):1147-1157. Epub 2018 May 24.
Department of Dermatology, Venereology and Allergy, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University and Centre of Excellence of Dermatology of Baden-Württemberg, Mannheim, Germany.
Background: T-lymphocytes are involved in tumor progression and regression. Actinic keratoses (AK) are atypical proliferations of keratinocytes of the skin. Some AK progress into invasive cutaneous squamous cell carcinomas (cSCC). Read More
Cureus 2018 Mar 15;10(3):e2331. Epub 2018 Mar 15.
Dermatology, Derm Surgery Associates, PA.
Keratoacanthoma (KA) is a squamous neoplasm exhibiting a triphasic growth pattern involving rapid growth, stabilization, and eventual spontaneous resolution. Historically, keratoacanthomas were thought to originate on hair-bearing skin or sun-exposed surfaces. However, recent reports demonstrate that they can occur on the mucous membranes, subungual regions, and palms and soles. Read More
Jpn J Clin Oncol 2018 Jun;48(6):514-521
Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
Background: Muir-Torre syndrome (MTS) is currently considered as a clinical variant of Lynch syndrome (LS). The clinical significance of the screening of patients with MTS-associated cutaneous tumors for the identification of LS has not yet been established. In addition, the prevalence and molecular characteristics of mismatch repair (MMR) protein deficiency in such tumors has scarcely been investigated in the Japanese population. Read More
J Eur Acad Dermatol Venereol 2018 Oct 27;32(10):1638-1644. Epub 2018 May 27.
Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Mohs micrographic surgery (MMS) is a good treatment option for epithelial neoplasms, especially when localized in areas where tissue conservation is crucial, such as the nail unit (NU). MMS is a method of radical excision offering high cure rates due to the margin control and functional preservation. Our aim is to provide a review on the use of MMS for the treatment of the most common nail tumours. Read More
J Cutan Pathol 2018 Jul 16;45(7):539-544. Epub 2018 May 16.
Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.
LL-37 is a naturally occurring 37-amino-acid peptide that is part of the innate immune system in human skin. Preclinical studies have showed that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a phase 1 clinical trial for melanoma patients with cutaneous metastases. Read More
Gan To Kagaku Ryoho 2018 Apr;45(4):622-624
Dept. of Dermatology, Hyogo Cancer Center.
Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
Department of Dermatology, University of California San Diego, La Jolla, California, USA.
Osteoma cutis, the development of bone in the dermis and/or subcutaneous fat, can occur as either a primary or secondary condition. Perforating osteoma cutis is rare. A man with a solitary lesion of perforating osteoma cutis is described and the features of individuals with a single perforating osteoma cutis skin lesion are reviewed. Read More
Open Access Maced J Med Sci 2018 Mar 8;6(3):531-535. Epub 2018 Mar 8.
University Clinic of Dermatology, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
Background: Keratoacanthoma (KA) is a rapidly growing epithelial tumour with histopathologic and clinical features similar to squamous cell carcinoma (SCC) and a certain tendency toward spontaneous regression.
Case Presentation: This article presents a unique and rare case of keratoacanthoma arising from the upper lip of a young male patient. These two features are in contrast to most of the reported cases in elder male individuals and on the lower lip. Read More
Georgian Med News 2018 Feb(Issue):77-80
Clinica Goldman, Porto Alegre, Rio Grande do Sul, Brazil; Department of Dermatology and Allergology, Municipal Hospital Dresden, Academic Teaching Hospital of the Technical University of Dresden, Germany.
Keratoakanthoma (KA) is a common non-melanoma skin tumor of sun-exposed skin. Recently it has been classified as a highly differentiated squamous cell carcinoma, based on the evidence of local destruction, tissue invasion and malignant transformation with metastatic spread described in the medical literature. Lower lip KA is not uncommon on lower lip, and quite rare on upper lip. Read More
Int J Dermatol 2018 09 25;57(9):1125-1127. Epub 2018 Mar 25.
Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Clin Dermatol 2018 Mar - Apr;36(2):167-176. Epub 2017 Oct 13.
Sinclair Dermatology, East Melbourne, VIC Australia; Faculty of Medicine, The University of Melbourne, Parkville, VIC Australia. Electronic address:
Epidermal cancers include keratinocyte cancer, melanocyte cancer, and Merkel cell carcinoma. These cancers account for the vast majority of new cancers diagnosed in Australia, North America, and Europe. Keratinocyte cancer is the most common epidermal cancer and accounts for 7 out of 8 new cancers diagnosed in Australia. Read More
Lancet Oncol 2018 Apr 21;19(4):510-520. Epub 2018 Feb 21.
Department of Dermatology, University Hospital Essen, Essen, Germany; German Cancer Consortium, Heidelberg, Germany.
Background: Systemic adjuvant treatment might mitigate the high risk of disease recurrence in patients with resected stage IIC-III melanoma. The BRIM8 study evaluated adjuvant vemurafenib monotherapy in patients with resected, BRAF mutation-positive melanoma.
Methods: BRIM8 was a phase 3, international, double-blind, randomised, placebo-controlled study that enrolled 498 adults (aged ≥18 years) with histologically confirmed stage IIC-IIIA-IIIB (cohort 1) or stage IIIC (cohort 2) BRAF mutation-positive melanoma that was fully resected. Read More
Front Microbiol 2018 5;9:117. Epub 2018 Feb 5.
Virology Unit, Department of Translational Medicine, Novara Medical School, University of Eastern Piedmont, Novara, Italy.
Many malignancies that occur in high excess in kidney transplant recipients (KTRs) are due to viruses that thrive in the setting of immunosuppression. Keratinocyte carcinoma (KC), the most frequently occurring cancer type in KTR, has been associated with skin infection by human papillomavirus (HPV) from the beta genus. In this report, we extend our previous investigation aimed at identifying the presence of active β-HPV infection in skin tumors from KTRs through detection of viral protein expression. Read More
J Cutan Pathol 2018 Apr 18;45(4):296-298. Epub 2018 Feb 18.
Associates in Dermatology, MD PL, Fort Myers, Florida.
Cutaneous intravascular CD30+ pseudolymphoma is an uncommon incidental finding that may mimic intravascular or angiotropic lymphoma. We describe a 78-year-old female with a traumatized regressing keratoacanthoma on her left cheek. A shave biopsy revealed intravascular staining of atypical lymphocytes positive for CD45, CD3 and CD30. Read More
Dermatol Ther (Heidelb) 2018 Mar 24;8(1):143-146. Epub 2018 Jan 24.
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Introduction: Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300-700 fold has been intensely investigated.
Case Presentation: Keratoacanthoma in an 86-year-old patient was treated with intralesional bleomycin combined with electroporation. Read More
Regul Toxicol Pharmacol 2018 Feb 24;92:382-389. Epub 2017 Dec 24.
Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:
Vismodegib (also known as GDC-0449) is a novel small molecule inhibitor of the Hedgehog (Hh) signaling pathway currently approved for the treatment of metastatic or locally advanced basal cell carcinoma (BCC) in humans. Its tumorigenic potential was assessed in dedicated carcinogenicity studies in rasH2 transgenic (Tg.rasH2) mice and Sprague Dawley (SD) rats. Read More
An Bras Dermatol 2017 ;92(5 Suppl 1):132-134
Dermatological Surgery Outpatient Clinic of the Department of Tropical Dermatology of Hospital Central do Exército (HCE) - Rio de Janeiro (RJ), Brazil.
In some cases, keratoacanthomas can be indistinguishable from squamous cell carcinoma, making the gold standard treatment surgical excision with histopathological evaluation. The surgical defects created on the back of the hand can be challenging to repair. We describe the use of bilateral rotation flap as an option in this area, and discuss the indications and contraindications of some of the possible surgical techniques for reconstruction of the dorsum of the hand. Read More
J Dermatol 2018 Apr 21;45(4):501-504. Epub 2017 Dec 21.
Department of Dermatology, Kansai Medical University, Osaka, Japan.
A 61-year-old man presented with a dome-shaped nodule, 1.2 cm in size, with a central crater covered by keratinous material near the left lateral malleolus. Histological findings demonstrated a basophilic circular cone in the center, surrounded and sharply demarcated by a broad eosinophilic area. Read More
Indian J Dermatol 2017 Nov-Dec;62(6):654-657
Department of Plastic Surgery, Medical College and Hospital, Kolkata, West Bengal, India.
Keratoacanthoma (KA) is a rapidly evolving benign cutaneous tumor, occurring in elderly individuals with a tendency towards spontaneous regression and histopathologic similarity to squamous cell carcinoma. Tumoral calcinosis is an uncommon condition, associated with the deposition of painless calcific masses. The occurrence of these two conditions in the same patient is a rarity itself, whereas deposition of calcium within the KA lesion in our 13-year-old patient makes it even more intriguing. Read More
Biomedicines 2017 Dec 20;5(4). Epub 2017 Dec 20.
Department of Dermatology, Dipartimento di Medicina Interna e Specialità Mediche, La Sapienza University of Rome, 00161 Rome, Italy.
Non-melanoma skin cancer (NMSC) is the most frequently diagnosed cancer in humans. Several different non-melanoma skin cancers have been reported in the literature, with several histologic variants that frequently cause important differential diagnoses with other cutaneous tumors basal cell carcinoma (BCC) is the most common malignant skin tumor, with different histologic variants that are associated with a greater or less aggressive behavior and that usually may be confused with other primitive skin tumors. Actinic keratosis, Bowen's disease, keratoacanthoma, and invasive squamous cell carcinoma (SCC) correspond to the other line of NMSC, that may have only local tumoral behavior, easy to treat and with local management (as in the case of actinic keratosis (AK), Bowen's disease, and keratoacanthoma) or a more aggressive behavior with a potential metastatic spread, as in case of invasive SCC. Read More
J Dermatol 2018 Jun 13;45(6):e152-e153. Epub 2017 Dec 13.
Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
Ann Dermatol Venereol 2017 Dec 7;144(12):776-783. Epub 2017 Nov 7.
Consultation « tatouage », service de dermatologie, hôpital Bichat - Claude-Bernard, hôpitaux universitaires Paris-Nord-Val-de-Seine, 46, rue Henri-Huchard, 75018 Paris, France.
Background: Increasing numbers of reports of rapidly arising, isolated or eruptive keratoacanthomas (KA) and squamous cell carcinomas (CSC) on the red part of tattoos tend to suggest a non-fortuitous link with the procedure. We report herein two different presentations of KAs on tattoos: one patient with multiple eruptive KAs on sun-exposed areas of a recent red tattoo and another with a solitary lesion on a recent tattoo. We discuss the issues related to the distinction between KAs and CSCs in this particular context. Read More
Aesthetic Plast Surg 2018 Feb 9;42(1):310-321. Epub 2017 Nov 9.
Department of Plastic, Aesthetic, Reconstructive and Hand Surgery, AGAPLESION Diakonieklinikum Rotenburg, Elise-Averdieck-Straße 17, 27356, Rotenburg (Wümme), Germany.
Background: The literature reports many cases of cutaneous malignancy in the setting of skin tattoos. In this study, we review the reported incidence of and risk factors for tattoo-associated skin cancer.
Methods: A PubMed literature review was performed for all cases of tattoo-associated skin cancer, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, keratoacanthoma, and other rare skin malignancies (source: PubMed/until June 2017). Read More
Br J Dermatol 2017 Nov 30;177(5):1225-1233. Epub 2017 Oct 30.
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A.
Although tremendous progress has been made in recent years in skin cancer care for organ transplant recipients, significant gaps remain in data-driven clinical guidelines, particularly for the treatment and prevention of cutaneous squamous cell carcinoma (cSCC), the most common malignancy among this population. In this review, we aim to summarize current knowledge around the management of cSCC and highlight the most significant gaps in knowledge that continue to pose challenges in the delivery of skin cancer care for organ transplant recipients. We suggest future directions for research that will bridge existing gaps and establish evidence-driven guidelines for primary prevention, screening and treatment of cSCC in this high-risk patient population. Read More
Eur J Dermatol 2017 Oct;27(5):482-486
Unit of Dermatology, University of Padua, Via Gallucci 4, 35128 Padova, Italy.
Patients with advanced melanoma have a poor prognosis. Since the discovery of BRAF mutations in cutaneous melanoma, new pharmacological agents have been developed to inhibit this target. Although the survival of patients with advanced melanoma has improved with BRAF inhibitors, the emergence of drug resistance and the high incidence of cutaneous side effects represent important limitations. Read More
J Dermatol 2018 Feb 23;45(2):211-215. Epub 2017 Oct 23.
Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Herein, we report a unique case of generalized eruptive keratoacanthoma (GEKA) in a 47-year-old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions. He also had a 2-year history of vitiligo and long-term experience of working outdoors. Biopsies were consistent with keratoacanthoma . Read More
Pan Afr Med J 2017 2;27:238. Epub 2017 Aug 2.
Service Chirurgie Plastique, Brûlés et Chirurgie de la Main, Hôpital Avicenne, Rabat, Maroc.
We report the case of a 65-year old patient presenting with well-defined nodular basal cell carcinom measuring 5mm in diameter in the right paramedian nasal tip and the superior margin of the nasal wing, near the free edge. The tumor was removed, with resection margin of 1mm. It was associated with multiple hyperkeratotic lesions spread across his face. Read More
JAAD Case Rep 2017 Sep 8;3(5):457-459. Epub 2017 Sep 8.
Department of Dermatology, Cleveland Clinic, Cleveland, Ohio.
G Ital Dermatol Venereol 2017 Oct;152(5):524-526
Molecular Dermatology Research Center and Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
We report here a case of a child with multiple keratoacanthoma centrifugum marginatum in association with corneal epithelial defect and juvenile arthritis. Keratoacanthoma is a skin tumor and the patient presented with an uncommon type of it. Read More
G Ital Dermatol Venereol 2017 Sep 8. Epub 2017 Sep 8.
Laboratorio di Dermatopatologia, Istituto San Gallicano di Roma, Roma, Italy.
Dermatol Clin 2017 Oct 7;35(4):417-437. Epub 2017 Aug 7.
Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 16 East 60th Street, New York, NY 10022, USA. Electronic address:
Dermoscopy increases the sensitivity for skin cancer detection, decreases the number of benign lesions biopsied for each malignant diagnosis, and enables the diagnosis of thinner melanomas compared with naked eye examination. Multiple meta-analyses have identified that dermoscopy improves the diagnostic accuracy for melanoma when compared with naked eye examination. In addition, studies have established that dermoscopy can aid in the detection of keratinocyte carcinomas. Read More