4,776 results match your criteria Keratitis Herpes Simplex


Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators.

Front Immunol 2020 13;11:766. Epub 2020 May 13.

Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, China.

Herpes stromal keratitis (HSK) is one of the primary diseases that cause vision loss or even blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is predominantly due to corneal scarring and neovascularization caused by inflammation. In the infected cornea, HSV can activate innate and adaptive immune responses of host cells, which triggers a cascade of reactions that leads to the release of inflammatory cytokines, chemokines, microRNA, and other regulatory factors that have stimulating or inhibitory effects on tissue. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237736PMC

Arthrographis kalrae Keratitis Complicated by Endophthalmitis: A Case Report With Literature Review.

Eye Contact Lens 2020 May 14. Epub 2020 May 14.

Division of Clinical Neuroscience (D.S.J.T.), Academic Ophthalmology, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Ophthalmology (D.S.J.T.), Queen's Medical Centre, Nottingham, United Kingdom; Departments of Ophthalmology (D.S.J.T., M.M., S.N.S., T.P.), and Microbiology (J.M.), James Cook University Hospital, Middlesbrough, United Kingdom; and National Specialist Ophthalmic Pathology Service (H.S.M.), Royal Hallamshire Hospital, Sheffield, United Kingdom.

Objectives: To report the first case of Arthrographis kalrae keratitis complicated by endophthalmitis in the UK and to review the current literature.

Methods: A case report with literature review.

Results: A 65-year-old male patient, with a background of treated B-cell lymphoma and herpes simplex virus-related neurotrophic keratopathy, presented with a large infiltrative corneal ulcer in the right eye. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000713DOI Listing

Shotgun sequencing to determine corneal infection.

Am J Ophthalmol Case Rep 2020 Sep 8;19:100737. Epub 2020 May 8.

International Center for Ocular Physiopathology, The Veneto Eye Bank Foundation, Venice, Italy.

Purpose: To investigate if shotgun-sequencing method could be useful in detailed diagnosis of herpes simplex virus (HSV) infection and compare it with the conventional diagnostic method.

Observations: Using a sterile scraper, the infectious part of the ocular surface was scraped gently and placed on a glass slide for conventional diagnosis using PCR and histology and in RNA stabilizing reagent for shotgun sequencing respectively. Concentration of the DNA was determined using a sensitive fluorescence dye-based Qubit dsDNA HS Assay Kit. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229483PMC
September 2020

Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection.

mBio 2020 May 12;11(3). Epub 2020 May 12.

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

Ocular herpes simplex virus 1 (HSV-1) infection leads to an immunopathogenic disease called herpes stromal keratitis (HSK), in which CD4 T cell-driven inflammation contributes to irreversible damage to the cornea. Herpesvirus entry mediator (HVEM) is an immune modulator that activates stimulatory and inhibitory cosignals by interacting with its binding partners, LIGHT (TNFSF14), BTLA (B and T lymphocyte attenuator), and CD160. We have previously shown that HVEM exacerbates HSK pathogenesis, but the involvement of its binding partners and its connection to the pathogenic T cell response have not been elucidated. Read More

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http://dx.doi.org/10.1128/mBio.00790-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218284PMC

BX795 Demonstrates Potent Antiviral Benefits against Herpes Simplex Virus-1 Infection of Human Cell Lines.

Antiviral Res 2020 May 4:104814. Epub 2020 May 4.

Department of Ophthalmology and Visual Sciences, University of Illinois Medical Center, Chicago, IL 60612, USA; Department of Bioengineering, University of Illinois, Chicago, IL 60607, USA. Electronic address:

Herpes simplex virus-1 (HSV-1) infection is known to cause skin blisters, keratitis as well as deadly cases of encephalitis in some situations. Only a few therapeutic modalities are available for this globally prevalent infection. Very recently, a small molecule BX795 was identified as an inhibitor of HSV-1 protein synthesis in an ocular model of infection. Read More

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http://dx.doi.org/10.1016/j.antiviral.2020.104814DOI Listing
May 2020
3.938 Impact Factor

TRIM21 Aggravates Herpes Simplex Virus Epithelial Keratitis by Attenuating STING-IRF3-Mediated Type I Interferon Signaling.

Front Microbiol 2020 16;11:703. Epub 2020 Apr 16.

Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, China.

Herpes simplex virus-1 (HSV-1) is the leading cause of infectious blindness in the developed world. HSV-1 infection can occur anywhere in the eye, and the most common presentation is epithelial keratitis. In the HSV epithelial keratitis mice model, we detected the expression of TRIM21 and then investigated the clinical relationship between TRIM21 and HSV epithelial keratitis by silencing TRIM21. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176818PMC

Corneal Neurotization for Postherpetic Neurotrophic Keratopathy: Initial Experience and Clinical Outcomes.

Ophthalmic Plast Reconstr Surg 2020 Apr 23. Epub 2020 Apr 23.

Department of Ophthalmology, Duke University, Durham, North Carolina, U.S.A.

Purpose: To assess early outcomes of corneal neurotization for postherpetic neurotrophic keratopathy (NK).

Methods: Retrospective analysis of patients who underwent corneal neurotization for postherpetic NK by a single experienced oculoplastic surgeon was performed. Collected data included stage and etiology of NK as well as comorbidities, prior treatment history, neurotization technique, donor nerve site, preoperative and postoperative examination findings (i. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001676DOI Listing

Lipidomic profiling of virus infection identifies mediators that resolve herpes simplex virus-induced corneal inflammatory lesions.

Analyst 2020 Apr 22. Epub 2020 Apr 22.

Minhang Hospital & Institutes of Biomedical Sciences & Department of Systems Biology for Medicine, Fudan University, Shanghai, 200032, P. R. China.

Lipid mediators (LMs) play a pivotal role in the induction and resolution of inflammation. To identify and elucidate their involvement during virus infection, multiple reaction monitoring (MRM) based liquid chromatography-tandem mass spectrometry lipidomic profiling of 62 lipid species was performed in this study. Results show that RAW264. Read More

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http://dx.doi.org/10.1039/d0an00263aDOI Listing

MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway.

Sci Rep 2020 Apr 21;10(1):6671. Epub 2020 Apr 21.

Department of Cell Biology, Kyoto Pharmaceutical University, Misasagi-Shichonocho 1, Yamashinaku, Kyoto, 607-8412, Japan.

Herpes simplex virus 1 (HSV-1) causes a number of clinical manifestations including cold sores, keratitis, meningitis and encephalitis. Although current drugs are available to treat HSV-1 infection, they can cause side effects such as nephrotoxicity. Moreover, owing to the emergence of drug-resistant HSV-1 strains, new anti-HSV-1 compounds are needed. Read More

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http://dx.doi.org/10.1038/s41598-020-63438-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174428PMC

HSV-1 infection and pathogenesis in the tree shrew eye following corneal inoculation.

J Neurovirol 2020 Apr 16. Epub 2020 Apr 16.

Key Laboratory of Animal Models and Human Disease Mechanism of the Chinese Academy of Science/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.

Herpes simplex virus type I (HSV-1) infection causes inflammation in the cornea known as herpes simplex virus keratitis (HSK), a common but serious corneal disease. It is not entirely clear whether the virus during recurring infection comes from the trigeminal ganglia or the eye tissue, including the retina and ciliary ganglion. Because the tree shrew is closely related to primates and tree shrew eye anatomic structures are similar to humans, we studied HSV-1 corneal infection in the tree shrew. Read More

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http://dx.doi.org/10.1007/s13365-020-00837-0DOI Listing
April 2020
2.595 Impact Factor

Protective effect of total flavonoids from Ixeris Sonchifolia on herpes simplex virus keratitis in mice.

BMC Complement Med Ther 2020 Apr 15;20(1):113. Epub 2020 Apr 15.

Department of Dermatology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Background: To investigate the protective effect of Ixeris Sonchifolia (Bae.) Hance (ISH) extract on herpes simplex virus keratitis (HSK) in mice.

Methods: A mouse model of HSK was established by inoculating 60 mice (60 right eyes) with herpes simplex virus type 1 (HSV-1) by corneal scratch. Read More

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http://dx.doi.org/10.1186/s12906-020-02911-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160970PMC

Concomitant herpes simplex keratitis and autoimmune-associated ulcerative keratitis in rheumatoid arthritis patients.

Am J Ophthalmol Case Rep 2020 Jun 9;18:100648. Epub 2020 Mar 9.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Purpose: To describe four cases of concomitant herpes simplex keratitis (HSK) and autoimmune-associated ulcerative keratitis (UK) in patients with rheumatoid arthritis (RA).

Observations: All patients developed HSK and UK while undergoing treatment for RA. The average age of onset for RA, UK and HSK was 49. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136173PMC

Herpetic Eye Disease Study: A Controlled Trial of Topical Corticosteroids for Herpes Simplex Stromal Keratitis.

Ophthalmology 2020 Apr;127(4S):S5-S18

Purpose: To evaluate the efficacy of topical corticosteroids in treating herpes simplex stromal keratitis.

Methods: The authors performed a randomized, double-masked, placebo-con- trolled, multicenter clinical trial of 106 patients with active herpes simplex stromal keratitis who had not received any corticosteroids for at least 10 days before study enrollment. Patients were assigned to the placebo group (n = 49) or the steroid group (topical prednisolone phosphate; n = 57); both regimens were tapered over 10 weeks. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.01.037DOI Listing

Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1.

Acta Pharm Sin B 2020 Mar 22;10(3):383-398. Epub 2019 Jun 22.

Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.

Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral tissues nerve termini. The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny, and thus latency is established in the cell. Read More

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http://dx.doi.org/10.1016/j.apsb.2019.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049575PMC

Role of Insulin-Like Growth Factor Binding Protein-3 in the Pathogenesis of Herpes Stromal Keratitis.

Invest Ophthalmol Vis Sci 2020 02;61(2):46

.

Purpose: The goal of this study was to determine the role of insulin-like growth factor-binding protein-3 (IGFBP-3) in the pathogenesis of herpes stromal keratitis (HSK).

Methods: In an unbiased approach, a membrane-based protein array was carried out to determine the level of expression of pro- and anti-angiogenic molecules in uninfected and HSV-1 infected corneas. Quantitative RT-PCR and ELISA assays were performed to measure the amounts of IGFBP-3 at mRNA and protein levels. Read More

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http://dx.doi.org/10.1167/iovs.61.2.46DOI Listing
February 2020
3.404 Impact Factor

Bowman Layer Onlay Transplantation to Manage Herpes Corneal Scar.

Cornea 2020 Feb 17. Epub 2020 Feb 17.

Netherlands Institute for Innovative Ocular Surgery (NIIOS), Rotterdam, The Netherlands.

Purpose: To introduce the concept of using a Bowman layer (BL) onlay graft to manage superficial herpetic corneal scarring and to describe the clinical outcomes of the first 2 cases undergoing this procedure.

Methods: Two patients with a quiescent superficial corneal scar after herpes (varicella zoster virus [n = 1] and herpes simplex virus [n = 1]) keratitis underwent BL onlay transplantation. After the removal of the host epithelium and limited superficial keratectomy, an isolated BL graft was placed onto the host corneal surface. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002292DOI Listing
February 2020

Herpes Simplex DNA in Tears of Atypical Dendritic Keratitis and Multiple Punctate Subepithelial Stromal Opacity: A Case Report.

Cornea 2020 Feb 17. Epub 2020 Feb 17.

Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.

Purpose: To report an atypical presentation of herpes simplex virus (HSV) keratitis followed up using expression levels of HSV DNA in tears.

Methods: A 22-year-old Japanese woman with hyperemia and foreign body sensation in her left eye was diagnosed with atypical dendritic keratitis. A slit-lamp examination at presentation indicated the presence of a rush of dendritic lesions with a sparse branching pattern and poor development of terminal bulbs; follicular conjunctivitis was also observed. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002293DOI Listing
February 2020

Development, Implementation, and Evaluation of Treatment Guidelines for Herpes Simplex Keratitis in Sydney, Australia.

Cornea 2020 Feb 11. Epub 2020 Feb 11.

Discipline of Ophthalmology, The University of Sydney, Save Sight Institute, Sydney Medical School, Sydney, New South Wales, Australia.

Purpose: To develop and measure the uptake of a local guideline for herpes simplex keratitis (HSK) and to standardize initial antiviral therapy in Australia.

Methods: The Registered Nurses' Association of Ontario Toolkit: "Implementation of Best Practice Guidelines" was used to develop, implement, and evaluate the guideline at Sydney Eye Hospital. An implementation team was established to reach consensus on antiviral therapy guidelines through review of available evidence, identifying stakeholders, facilitators and barriers, creating strategies for implementation, and developing a sustainability plan. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002273DOI Listing
February 2020

Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis.

PLoS One 2020 6;15(2):e0228252. Epub 2020 Feb 6.

Division of Biotechnology and Molecular Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America.

Herpes simplex virus type-1 (HSV-1) can cause severe ocular infection and blindness. We have previously shown that the HSV-1 VC2 vaccine strain is protective in mice and guinea pigs against genital herpes infection following vaginal challenge with HSV-1 or HSV-2. In this study, we evaluated the efficacy of VC2 intramuscular vaccination in mice against herpetic keratitis following ocular challenge with lethal human clinical strain HSV-1(McKrae). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228252PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004361PMC

Nerve growth factor inhibits TLR3-induced inflammatory cascades in human corneal epithelial cells.

J Inflamm (Lond) 2019 26;16:27. Epub 2019 Dec 26.

Department of Ophthalmology and Visual Science, Eye & ENT Hospital, NHC Key Laboratory of myopia (Fudan University); Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai Medical College of Fudan University, Shanghai, 200031 China.

Background: In herpes simplex epithelial keratitis, excessive TLR3-induced cellular responses after virus infection evoke inflammatory cascades that might be destructive to the host cornea. Nerve growth factor (NGF), a pluripotent neurotrophic factor with immune regulatory effect, was proved to be effective in Herpes simplex keratitis (HSK) treatment, although the detailed mechanisms remain unclear. This study aims to investigate the effects of NGF on modulating inflammatory responses triggered by TLR3 activation in human corneal epithelial cells (HCECs) in vitro. Read More

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http://dx.doi.org/10.1186/s12950-019-0232-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933932PMC
December 2019

Topical Tacrolimus as an adjunct to Conventional Therapy for Stromal Herpetic Keratitis: a Randomized Clinical Trial.

J Ophthalmic Vis Res 2019 Oct-Dec;14(4):400-411. Epub 2019 Oct 24.

Department of Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Purpose: This study investigates the effects of 0.05% topical tacrolimus as an adjunct therapy for patients with non-necrotizing herpetic stromal keratitis (HSK).

Methods: Patients with non-necrotizing HSK, referred to the Cornea Clinic at Hospital in Rasht, Iran, between September 2016 and February 2018, were randomly assigned to two groups. Read More

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http://dx.doi.org/10.18502/jovr.v14i4.5437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825688PMC
October 2019

[Research progress of corneal neovascularization in herpes stromal keratitis].

Authors:
Y Zhang S W Ren

Zhonghua Yan Ke Za Zhi 2019 Dec;55(12):956-960

Henan Eye Hospital, Henan Provincial People's Hospital, Henan Eye Institute, Zhengzhou 450003, China.

Herpes simplex virus (HSV) infection can cause inflammatory reactions and angiogenesis of the cornea, which significantly reduce corneal transparency. Herpes stromal keratitis (HSK) is an immune mediated disease caused by HSV infection, and is associated with inflammation and angiogenesis of the cornea. It is difficult to control HSK therapeutically. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.12.017DOI Listing
December 2019

[Interstitial keratitis diagnosis and treatment (French translation of the article)].

J Fr Ophtalmol 2020 Jan 20;43(1):80-89. Epub 2019 Dec 20.

Service d'ophtalmologie, CHU Jean-Minjoz, 2, boulevard Fleming, 25030 Besançon cedex, France; Faculté de médecine et de pharmacie - Besançon, 20, rue Ambroise Paré, 25000 Besançon, France.

Interstitial keratitis is a non-ulcerative, non-suppurative, more or less vascularized inflammation of the corneal stroma. The corneal lesions result from the host response to bacterial, viral (40% of cases) or parasitic antigens, or from an autoimmune response (1% of cases) without active corneal infection. The natural history of the disease is divided into two phases : acute and cicatricial. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.11.024DOI Listing
January 2020

Herpes Simplex Virus 1-Specific CD8 T Cell Priming and Latent Ganglionic Retention Are Shaped by Viral Epitope Promoter Kinetics.

J Virol 2020 Feb 14;94(5). Epub 2020 Feb 14.

Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Reactivation of herpes simplex virus 1 (HSV-1) from neurons in sensory ganglia such as the trigeminal ganglia (TG) is influenced by virus-specific CD8 T cells that infiltrate the ganglia at the onset of latency and contract to a stable activated tissue-resident memory population. In C57BL/6 mice, half of HSV-specific CD8 T cells (gB-CD8s) recognize one dominant epitope (residues 498 to 505) on glycoprotein B (gB), while the remainder (non-gB-CD8s) recognize 19 subdominant epitopes from 12 viral proteins. To address how expression by HSV-1 influences the formation and ganglionic retention of CD8 T cell populations, we developed recombinant HSV-1 with the native immunodominant gB epitope disrupted but then expressed ectopically from different viral promoters. Read More

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http://dx.doi.org/10.1128/JVI.01193-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022356PMC
February 2020

Clinical Pattern And Visual Impairment Associated With Herpes Simplex Keratitis.

Clin Ophthalmol 2019 12;13:2211-2215. Epub 2019 Nov 12.

Department of Cornea, Mechi Eye Hospital, Birtamode, Nepal.

Purpose: Herpes simplex keratitis (HSK) has varied presenting patterns, and is one of the leading causes of corneal scarring and subsequent visual disability. This study was carried out to determine the incidence and patterns of HSK presenting at a tertiary eye center in eastern Nepal and to assess the associated visual impairment.

Methods: This was a descriptive, cross-sectional study at a tertiary eye-care center that included 302 cases of clinically diagnosed HSK over a period of 1 year. Read More

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http://dx.doi.org/10.2147/OPTH.S219184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858806PMC
November 2019

The Role of C21orf91 in Herpes Simplex Virus Keratitis.

Medicina (Kaunas) 2019 Nov 20;55(12). Epub 2019 Nov 20.

Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.

This paper aims to describe the single nucleotide polymorphisms (SNPs) of C21orf91 rs1062202 and rs10446073 in patients with herpetic keratitis by evaluating corneal sub-basal nerves, as well as the density of Langerhans cells (LC) and endothelium cells (EC) during the acute phase of the disease. : A prospective clinical study included 260 subjects: 70 with herpetic eye disease, 101 with previous history of herpes labialis-but no history of herpetic eye disease-and 89 with no history of any herpes simplex virus (HSV) diseases. All subjects underwent a complete ophthalmological examination including in vivo laser scanning confocal microscopy (LSCM) of the central cornea. Read More

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http://dx.doi.org/10.3390/medicina55120753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956000PMC
November 2019

Atypical herpes simplex keratitis: frequency, clinical presentations and treatment results.

Int Ophthalmol 2020 Mar 21;40(3):659-665. Epub 2019 Nov 21.

Virology Department, Faculty of Medicine, Balcali Hospital, Cukurova University, 01380, Saricam, Adana, Turkey.

Aims: To determine herpes simplex virus (HSV) DNA positivity in corneal scraping samples obtained from patients with microbial keratitis whose findings were not specific for HSV keratitis and to evaluate these particular cases with respect to clinical features and antiviral treatment results.

Methods: Records of patients with microbial keratitis treated in a tertiary eye care hospital within the 3-year period were evaluated retrospectively. Real-time polymerase chain reaction (PCR) was used to identify HSV DNA. Read More

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http://dx.doi.org/10.1007/s10792-019-01226-1DOI Listing

Intrastromal bevacizumab in the management of corneal neovascularization: a retrospective review.

Graefes Arch Clin Exp Ophthalmol 2020 Jan 12;258(1):167-173. Epub 2019 Nov 12.

Department of Ophthalmology & Visual Neurosciences, University of Minnesota, Phillips Wagensteen Building, Ninth Floor, 516 Delaware Street SE, Minneapolis, MN, 55455, USA.

Purpose: To evaluate the long-term safety and efficacy of intrastromal bevacizumab for treatment of deep corneal neovascularization in candidates for high-risk cornea grafting.

Methods: A single-center retrospective study involving 14 eyes of 14 patients with chronic deep corneal neovascularization, treated with intrastromal bevacizumab by a single provider from 2011 to present. Intrastromal bevacizumab (0. Read More

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http://dx.doi.org/10.1007/s00417-019-04519-4DOI Listing
January 2020

Challenges in the diagnosis of microbial keratitis: A detailed review with update and general guidelines.

Saudi J Ophthalmol 2019 Jul-Sep;33(3):268-276. Epub 2019 Sep 11.

Department of Ophthalmology, College of Medicine, King Saud University-Medical City, Riyadh, Saudi Arabia.

The incidence of microbial keratitis (MK) is variable worldwide with an estimated 1.5-2 million cases of corneal ulcers in developing countries. The complications of MK can be severe and vision threatening. Read More

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http://dx.doi.org/10.1016/j.sjopt.2019.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819704PMC
September 2019
1 Read

Bilateral Herpetic Keratitis in Atopic Dermatitis.

Mayo Clin Proc 2019 11;94(11):2270-2271

Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.mayocp.2019.04.026DOI Listing
November 2019

Fetal and neonatal abnormalities due to congenital herpes simplex virus infection: a literature review.

Prenat Diagn 2020 Mar 2;40(4):408-414. Epub 2020 Jan 2.

Service de Gynécologie-Obstétrique, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, 178 rue des Renouillers, 92701, Colombes cedex, France.

Objective: Herpes simplex virus (HSV) infection during pregnancy can cause severe neonatal infections. It is also a rare cause of congenital infections. We aimed to describe fetal and neonatal abnormalities of congenital HSV infection in order to define the features that are accessible to prenatal diagnosis during ultrasound screening and/or during a work-up for congenital malformations. Read More

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http://dx.doi.org/10.1002/pd.5587DOI Listing
March 2020
1 Read

Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections.

Microorganisms 2019 Oct 10;7(10). Epub 2019 Oct 10.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor St, Chicago, IL 60612, USA.

Herpes simplex virus type-1 (HSV-1) is a neurotropic, double-stranded DNA virus that can cause a wide variety of diseases, including many ocular pathologies. It is one of the leading causes of infectious blindness in the United States. Because of its ubiquitous nature and its potential to cause serious ocular maladies, there is a significant need for more effective antiviral therapies against ocular HSV-1. Read More

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http://dx.doi.org/10.3390/microorganisms7100429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843252PMC
October 2019

Commentary: Targeting herpetic keratitis by immunomodulation of IL-27 signaling.

Authors:
Joveeta Joseph

Indian J Ophthalmol 2019 11;67(11):1828-1829

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

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http://dx.doi.org/10.4103/ijo.IJO_1364_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836589PMC
November 2019

Blockade of IL-27 signaling ameliorates herpes stromal keratitis with upregulated CD4 Foxp3 regulatory T cells influx in mice.

Indian J Ophthalmol 2019 11;67(11):1821-1828

Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.

Purpose: The purpose of this study was to investigate the production of IL-27 p28 and EBI3 in the ocular inflammatory sites, and the role of IL-27 signaling in a model of HSV-1 induced herpetic stromal keratitis (HSK).

Methods: The BALB/c mice were injected intraperitoneally (24 h before infection) with anti-IL-27 antibody or IgG antibody as control, infected with HSV-1 via corneal scarification, and then injected intraperitoneally with anti-IL-27 antibody or IgG antibody at 1, 3, and 5 days postinfection. Slit lamp and histopathology were used to assess disease outcome. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1780_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836587PMC
November 2019
1 Read
0.927 Impact Factor

Biological Staining and Culturing in Infectious Keratitis: Controversy in Clinical Utility.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(3):145-151

Hoopes Durrie Rivera Research Center, Hoopes Vision, Draper, UT, USA.

Infectious keratitis causes significant, financial burden and is only increasing in frequency with contact lens use. Despite this, no retrospective studies, prospective studies, or clinical trials have evaluated the diagnostic validity of clinical guidelines in cases of infectious keratitis. Currently, standard of care recommends that corneal samples be obtained for staining and culturing in select patients showing evidence of corneal ulceration. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778464PMC
January 2019
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Use of Collagen Binding Domains to Deliver Molecules to the Cornea.

J Ocul Pharmacol Ther 2019 11 10;35(9):491-496. Epub 2019 Oct 10.

Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

The combined activity of the tear film and blinking is remarkably efficient at removal of foreign materials from the ocular surface. This has prevented the use of certain classes of drugs for the treatment of ocular surface problems. We propose that the use of peptide and protein domains that bind to moieties on the cornea could be used to deliver therapeutics by anchoring the drugs on the ocular surface long enough to provide therapeutic effects. Read More

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http://dx.doi.org/10.1089/jop.2019.0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839418PMC
November 2019
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Looking into nerve damage in the cornea.

Authors:
Mihaela Gadjeva

Elife 2019 10 8;8. Epub 2019 Oct 8.

Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Boston, United States.

Interactions between T helper cells and the complement system promote loss of sensory neurons in the eye. Read More

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http://dx.doi.org/10.7554/eLife.51497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783260PMC
October 2019

Ocular manifestations of herpes simplex virus.

Curr Opin Ophthalmol 2019 Nov;30(6):525-531

Byers Eye Institute, Stanford University, Palo Alto, California, USA.

Purpose Of Review: To review ocular manifestations and complications of herpes simplex virus (HSV) and discuss recent advancements in diagnostic and treatment strategy.

Recent Findings: In-vivo confocal microscopy has expanded our understanding of corneal nerve degeneration, corneal dendritic cell activity, and changes in biomechanical properties in HSV keratitis. Although currently available only as a research tool, metagenomic deep sequencing has the potential to improve diagnostic accuracy beyond the well established PCR technology, especially in atypical cases. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000618DOI Listing
November 2019
8 Reads

Genetic Variations in Patients with Recurrent Herpes Simplex Keratitis.

Medicina (Kaunas) 2019 Sep 26;55(10). Epub 2019 Sep 26.

Emergency Center, Clinic for Emergency surgery, Clinical Center of Serbia, 11000 Belgrade, Serbia.

: Recurrent herpes simplex keratitis (HSK) is the most common cause of corneal blindness in the developed world. A relationship between host gene polymorphisms and the recurrence of herpes simplex virus (HSV) infection has previously been proposed. Thus, the aim of this study was to investigate a potential association between the host genotype and recurrent HSK. Read More

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http://dx.doi.org/10.3390/medicina55100642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843532PMC
September 2019
2 Reads

CCR6-Positive γδ T Cells Provide Protection Against Intracorneal HSV-1 Infection.

Invest Ophthalmol Vis Sci 2019 09;60(12):3952-3962

Department of Microbiology & Immunology, University of South Alabama Mobile, Alabama, United States.

Purpose: γδ T cells offer an important early immune defense against many different pathogens, both bacterial and viral. Herein, we examined the capacity of γδ T cell subsets to provide protection in the cornea against herpes simplex virus-1 (HSV-1).

Methods: C57Bl/6 (wild-type [WT]), γδ T-cell deficient (TCRδ-/-) and CCR6-deficient (CCR6-/-) mice were infected intracorneally with HSV-1. Read More

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http://dx.doi.org/10.1167/iovs.19-27810DOI Listing
September 2019
3 Reads

Herpes Simplex Virus 1 Replication, Ocular Disease, and Reactivations from Latency Are Restricted Unilaterally after Inoculation of Virus into the Lip.

J Virol 2019 12 26;93(24). Epub 2019 Nov 26.

Institut de Biologie Intégrative de la Cellule (I2BC), Département de Virologie, CNRS, Gif-sur-Yvette, France

Ocular herpes simplex keratitis (HSK) is a consequence of viral reactivations from trigeminal ganglia (TG) and occurs almost exclusively in the same eye in humans. In our murine oro-ocular (OO) model, herpes simplex virus 1 (HSV-1) inoculation in one side of the lip propagates virus to infect the ipsilateral TG. Replication here allows infection of the brainstem and infection of the contralateral TG. Read More

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http://dx.doi.org/10.1128/JVI.01586-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880161PMC
December 2019
2 Reads

Systemic IL-1β production as a consequence of corneal HSV-1 infection-contribution to the development of herpes simplex keratitis.

Int J Ophthalmol 2019 18;12(9):1493-1497. Epub 2019 Sep 18.

Department of Ophthalmology, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

This study sought to identify potential therapeutic targets in herpes simplex keratitis (HSK) patients with active and inactive infection by investigating peripheral cytokine production. Peripheral blood mononuclear cells (PBMCs) and serum were prepared from healthy controls and HSK patients during active infection or following treatment (inactive infection). Serum antibody titres were determined by ELISA. Read More

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http://dx.doi.org/10.18240/ijo.2019.09.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739588PMC
September 2019
5 Reads

MicroRNAs in Ocular Infection.

Microorganisms 2019 Sep 17;7(9). Epub 2019 Sep 17.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, School of Medicine, Detroit, MI 48201, USA.

MicroRNAs (miRNAs) are small, non-coding, regulatory RNA molecules and constitute a newly recognized, important layer of gene-expression regulation at post-transcriptional levels. miRNAs quantitatively fine tune the expression of their downstream genes in a cell type- and developmental stage-specific fashion. miRNAs have been proven to play important roles in the normal development and function as well as in the pathogenesis of diseases in all tissues and organ systems. Read More

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https://www.mdpi.com/2076-2607/7/9/359
Publisher Site
http://dx.doi.org/10.3390/microorganisms7090359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780979PMC
September 2019
3 Reads

Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: friends or foes?

Crit Rev Microbiol 2019 Sep - Nov;45(5-6):581-594. Epub 2019 Sep 12.

Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China.

Microglia, as brain-resident macrophages, are the first line of defense against brain invading pathogens. Further, their dysfunction has been recognized to be closely associated with mounting CNS diseases. Of note, chronic HSV-1 infection leads to the persistent activation of microglia, which elicit a comprehensive response by generating certain factors with neurotoxic and neuroprotective effects. Read More

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http://dx.doi.org/10.1080/1040841X.2019.1660615DOI Listing
May 2020
3 Reads
6.020 Impact Factor

Absence of Signal Peptide Peptidase, an Essential Herpes Simplex Virus 1 Glycoprotein K Binding Partner, Reduces Virus Infectivity .

J Virol 2019 12 13;93(23). Epub 2019 Nov 13.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA

We previously reported that herpes simplex virus (HSV) glycoprotein K (gK) binds to signal peptide peptidase (SPP), also known as minor histocompatibility antigen H13. Binding of gK to SPP is required for HSV-1 infectivity SPP is a member of the γ-secretase family, and mice lacking SPP are embryonic lethal. To determine how SPP affects HSV-1 infectivity , the SPP gene was deleted using a tamoxifen-inducible Cre recombinase driven by the ubiquitously expressed ROSA26 promoter. Read More

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http://dx.doi.org/10.1128/JVI.01309-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854508PMC
December 2019
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Recurrent herpes zoster ophthalmicus in a young, healthy individual taking high doses of l-Arginine.

Am J Ophthalmol Case Rep 2019 Dec 20;16:100547. Epub 2019 Aug 20.

LoBue Laser & Eye Medical Centers, Murrieta, CA, USA.

Purpose: To report a case of a healthy, young male with recurrent herpes zoster ophthalmicus (HZO) and high-dose l-arginine supplementation.

Observations: A 39-year-old man presented to another institution with a HZO involving the right eye. He was treated with oral acyclovir with complete resolution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183020
Publisher Site
http://dx.doi.org/10.1016/j.ajoc.2019.100547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722283PMC
December 2019
2 Reads

Descemet Membrane Endothelial Keratoplasty in Irreversible Corneal Edema Due to Herpes Simplex Virus Endotheliitis.

Cornea 2020 Jan;39(1):8-12

Cornea Department, Disha Eye Hospitals, Barrackpore, Kolkata, India.

Purpose: To report the clinical outcome and postoperative course of Descemet membrane endothelial keratoplasty (DMEK) in irreversible corneal edema due to herpes simplex virus (HSV) endotheliitis.

Methods: This is a retrospective, noncomparative, interventional case series. Nineteen eyes of 19 patients underwent standard DMEK combined with cataract surgery (triple DMEK) between May 2016 and April 2018. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002135DOI Listing
January 2020
6 Reads

Herpes Simplex Virus Keratitis.

Authors:
Karen D Harris

Home Healthc Now 2019 Sep/Oct;37(5):281-284

Karen D. Harris, MSN, RN, ACNS-BC, is an Assistant Professor, McAuley School of Nursing, University of Detroit Mercy, Detroit, Michigan.

Herpes simplex virus (HSV) is a highly prevalent infection in the United States. One complication of HSV is HSV keratitis, an ocular HSV infection thought to be the leading cause of corneal blindness in the United States. Home care clinicians with knowledge of the signs and symptoms of HSV and HSV keratitis can aid in early detection and treatment of this potentially serious infection. Read More

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http://dx.doi.org/10.1097/NHH.0000000000000791DOI Listing
February 2020
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