4,994 results match your criteria Keratitis Herpes Simplex

First reported case of corneal infection caused by .

BMJ Case Rep 2022 Jun 27;15(6). Epub 2022 Jun 27.

Microbiology services, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, India

A man in his 20s, with irritation, pain and photophobia in the left eye, was clinically diagnosed with herpes simplex virus nummular keratitis at our institute and advised topical antivirals and corticosteroids, causing resolution of active infiltrates. The infection recurred after 7 months and the patient did not respond to the previous regimen, so corneal scraping was sent for microbiological evaluation. Gram-positive bacilli grew on culture, which were identified as using VITEK 2 Compact system (bioMérieux, Marcy l'Etoile, France). Read More

View Article and Full-Text PDF

Incidence and Risk Factors of Bilateral Herpetic Keratitis: 2022 Update.

Trop Med Infect Dis 2022 Jun 7;7(6). Epub 2022 Jun 7.

Ophthalmology Department, General Hospital of Volos, 134, Polymeri Str., 38221 Volos, Greece.

Simultaneously occurring bilateral herpetic keratitis is a rare clinical manifestation of ocular herpes. Immunocompromised patients are more susceptible to develop bilateral disease. The purpose of this study is to review recent literature on the topic and to highlight latest updates, regarding risk factors and possible correlations to the disease, as well as new therapeutic options. Read More

View Article and Full-Text PDF

[Two cases of herpes simplex keratitis after trans-epithelial photorefractive keratectomy].

Zhonghua Yan Ke Za Zhi 2022 Jun;58(6):448-452

Department of Ophthalmology, Dalian Third People's Hospital, Dalian 116033, China.

We herein report 2 cases of herpes simplex keratitis after trans-epithelial photorefractive keratectomy. Patients' medical histories, symptoms, signs, clinical examination results, diagnosis and treatment were showed in detail. Following precision diagnosis and medical intervention, including topical and systemic antiviral treatmented for 1 to 2 weeks. Read More

View Article and Full-Text PDF

Efficacy of an HSV-1 Neuro-Attenuated Vaccine in Mice Is Reduced by Preventing Viral DNA Replication.

Viruses 2022 04 22;14(5). Epub 2022 Apr 22.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

We previously isolated an HSV-1 mutant, KOS-NA, that contains two non-synonymous mutations in UL39. One of the mutations, resulting in an R950H amino acid substitution in ICP6, renders KOS-NA severely neuro-attenuated and significantly reduces HSV-1 latency. Vaccination of mice with KOS-NA prior to corneal challenge provides significant protection against HSV-1-mediated eye diseases even at a very low immunizing dose, indicating its utility as a vaccine scaffold. Read More

View Article and Full-Text PDF

Comparative Efficacy of Topical Ophthalmic Ganciclovir and Oral Famciclovir in Cats with Experimental Ocular Feline Herpesvirus-1 Epithelial Infection.

J Ocul Pharmacol Ther 2022 06 25;38(5):339-347. Epub 2022 May 25.

Department of Population Medicine & Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.

To determine the comparative efficacy of ganciclovir ophthalmic gel and famciclovir oral tablets in cats with experimentally induced ocular feline herpesvirus-1 (FHV-1) epithelial infection. A randomized, placebo-controlled trial was performed using 16 nonvaccinated, specific pathogen-free cats with experimental FHV-1 infection induced by topical ocular inoculation. Cats received topical ganciclovir 0. Read More

View Article and Full-Text PDF

Infectious keratitis: A review.

Clin Exp Ophthalmol 2022 May 24. Epub 2022 May 24.

Save Sight Institute, Discipline of Ophthalmology, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

Globally, infectious keratitis is the fifth leading cause of blindness. The main predisposing factors include contact lens wear, ocular injury and ocular surface disease. Staphylococcus species, Pseudomonas aeruginosa, Fusarium species, Candida species and Acanthamoeba species are the most common causal organisms. Read More

View Article and Full-Text PDF

Recurrence of Herpetic Keratitis after COVID-19 Vaccination: A Report of Two Cases.

Case Rep Ophthalmol Med 2022 19;2022:7094893. Epub 2022 May 19.

Ross Eye Institute, Department of Ophthalmology, Jacobs School of Medicine and Biomedical Sciences, State University at Buffalo, Buffalo, New York, USA.

Background: Recurrence of herpetic keratitis following vaccination has been documented following vaccination with the Zostavax, trivalent flu, hepatitis A, and rabies vaccines. The USFDA and WHO have acknowledged that the novel COVID-19 vaccines similarly have a risk of reactive immunologic-based inflammation, namely, myositis, pericarditis, and Guillain-Barré syndrome. . Read More

View Article and Full-Text PDF

Bell's palsy with Herpes simplex disciform keratitis: A case report.

Am J Ophthalmol Case Rep 2022 Sep 6;27:101575. Epub 2022 May 6.

Nassau University Medical Center, Department of Ophthalmology, East Meadow, NY, USA.

Purpose: To report a novel case of unilateral peripheral facial nerve palsy manifesting as a complication of Herpes simplex keratitis.

Observations: A 51-year-old immunocompetent male presented with severe eye pain for 3 weeks. He was found to have Herpes simplex keratitis in the left eye and started on valacyclovir 3g per day for 10 days. Read More

View Article and Full-Text PDF
September 2022

Initial TK-deficient HSV-1 infection in the lip alters contralateral lip challenge immune dynamics.

Sci Rep 2022 May 19;12(1):8489. Epub 2022 May 19.

Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB), Commissariat à l'énergie Atomique et Aux Énergies Renouvelables, Université Paris-Saclay, INSERM U1184, Fontenay-aux-Roses, France.

Primary infection with herpes simplex type 1 (HSV-1) occurring around the mouth and nose switches rapidly to lifelong latent infection in sensitive trigeminal ganglia (TG) neurons. Sporadic reactivation of these latent reservoirs later in life is the cause of acute infections of the corneal epithelium, which can cause potentially blinding herpes simplex keratitis (HSK). There is no effective vaccine to protect against HSK, and antiviral drugs provide only partial protection against recurrences. Read More

View Article and Full-Text PDF

Reply : Cataract surgery in herpes simplex virus ocular disease.

J Cataract Refract Surg 2022 07;48(7):873-874

From the Department of Ophthalmology, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand (Lu, Al-Ani, Meyer, Niederer); Department of Ophthalmology, University of Auckland, Auckland, New Zealand (Al-Ani, Meyer, Niederer).

View Article and Full-Text PDF

Comment on: Cataract surgery in herpes simplex virus ocular disease.

J Cataract Refract Surg 2022 07;48(7):872-873

From the Department of Ophthalmology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea (Cho); University of Oregon, Eugene, Oregon (Thomson, Ambati).

View Article and Full-Text PDF

The C-Terminal Penta-Peptide Repeats of Major Royal Jelly Protein 3 Ameliorate the Progression of Inflammation in Vivo and in Vitro.

Biol Pharm Bull 2022 ;45(5):583-589

Microbiology and Immunology, Gifu Pharmaceutical University.

Royal jelly (RJ) has been used as a functional foodstuff and in cosmetics for many years. RJ contains various molecules, including major royal jelly proteins (MRJPs), and affords a number of health benefits such as anti-inflammatory activity. As MRJP3 has been reported to possess anti-inflammatory properties by the in vitro analysis, we investigated the anti-inflammatory effects of MRJP3 and its derived peptides both in vitro and in vivo. Read More

View Article and Full-Text PDF

A proof-of-concept study for the efficacy of dispirotripiperazine PDSTP in a rabbit model of herpes simplex epithelial keratitis.

Antiviral Res 2022 06 27;202:105327. Epub 2022 Apr 27.

Research Centre of Biotechnology RAS, 33-2 Leninsky Prospect, 119071, Moscow, Russia. Electronic address:

Herpes simplex keratitis is an important infectious cause of blindness worldwide. The mainstay of antiviral therapy is treatment with long-established nucleoside analogues orally or topically. However, the emergence of resistant strains may become a major health concern in the future. Read More

View Article and Full-Text PDF

Analysis of MicroRNA Expression in Tears of Patients with Herpes Epithelial Keratitis: A Preliminary Study.

Invest Ophthalmol Vis Sci 2022 04;63(4):21

Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea.

Purpose: Herpes epithelial keratitis (HEK) is the most common form of herpes simplex virus (HSV) eye involvement, and understanding the molecular mechanisms underlying HEK is important. We investigated the expression of microRNAs (miRNAs) in the tears of patients with HEK.

Methods: Tear samples from eight patients with HEK and seven age-matched controls were evaluated. Read More

View Article and Full-Text PDF

Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection.

Front Microbiol 2022 8;13:869064. Epub 2022 Apr 8.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.

Herpes simplex virus type 1 (HSV1) remains one of the most ubiquitous human pathogens on earth. The classical presentation of HSV1 infection occurs as a recurrent lesions of the oral mucosa commonly refer to as the common cold sore. However, HSV1 also is responsible for a range of ocular diseases in immunocompetent persons that are of medical importance, causing vision loss that may result in blindness. Read More

View Article and Full-Text PDF

Bilateral Severe Herpes Simplex Endotheliitis with a Possible Association with Latanoprost.

Ocul Immunol Inflamm 2022 Apr 20:1-3. Epub 2022 Apr 20.

Jhaveri Microbiology Centre, LV Prasad Eye Institute, Hyderabad, India.

Purpose: To report bilateral Herpes Simplex virus (HSV) keratitis in a patient on latanoprost for primi]k=8ary open angle glaucoma (POAG).

Methods: Case report.

Results: A 76-year-old healthy male on latanoprost monotherapy for POAG polresented with sudden bilateral decreased vision. Read More

View Article and Full-Text PDF

Author Reply: Relapsed Disciform Stromal Herpetic Keratitis and mRNA COVID-19 Vaccination.

Kook Young Kim

Korean J Ophthalmol 2022 04 4;36(2):176-177. Epub 2022 Apr 4.

Department of Cornea, Kim's Eye Hospital, Seoul, Korea.

View Article and Full-Text PDF

Relapsed Disciform Stromal Herpetic Keratitis and mRNA COVID-19 Vaccination.

Korean J Ophthalmol 2022 04 4;36(2):176-177. Epub 2022 Apr 4.

Honorary Professor, Department of Community Medicine, Dr DY Patil University, Pune, India.

View Article and Full-Text PDF

Case Report: Novel Patient Training Technique for the Application and Removal of Scleral Lenses.

Optom Vis Sci 2022 Apr 13. Epub 2022 Apr 13.

BostonSight, Needham, Massachusetts.

Significance: This report shares a technique that can be utilized to assist training patients to properly and safely apply and remove prosthetic replacement of the ocular surface ecosystem devices (PD) or scleral lenses in order to reduce patient training nervousness, limit adverse events from training and limit training failures.

Purpose: To introduce a novel scleral lens application and removal training method.

Case Report: A 28-year-old female with limbal stem cell deficiency secondary to contact lens overwear in the left eye greater than the right eye presented for prosthetic replacement of the ocular surface ecosystem treatment. Read More

View Article and Full-Text PDF

Herpes Simplex Virus-1 Induced Serotonin-Associated Metabolic Pathways Correlate With Severity of Virus- and Inflammation-Associated Ocular Disease.

Front Microbiol 2022 22;13:859866. Epub 2022 Mar 22.

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.

Herpes simplex virus-associated diseases are a complex interaction between cytolytic viral replication and inflammation. Within the normally avascular and immunoprivileged cornea, HSV ocular infection can result in vision-threatening immune-mediated herpetic keratitis, the leading infectious cause of corneal blindness in the industrialized world. Viral replicative processes are entirely dependent upon numerous cellular biosynthetic and metabolic pathways. Read More

View Article and Full-Text PDF

Optineurin in ocular herpes infection.

Exp Eye Res 2022 Jun 4;219:109059. Epub 2022 Apr 4.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA; Department of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA. Electronic address:

Herpes Simplex Virus-1 (HSV-1) is a neurotropic virus that can infect humans in the eye and travel to the trigeminal ganglion to establish latency. HSV-1 causes various disease states in both the primary and secondary sites of infection including the eye and the nervous system. This DNA virus exploits various adaptive measures to infect host cells, hijack host cell proteins, evade host immune response and spread from cell-to-cell to avoid immune detection. Read More

View Article and Full-Text PDF

Chlorhexidine in the treatment of microsporidial stromal keratitis and the effect of host immunity: A case series and literature review.

J Chin Med Assoc 2022 04;85(4):532-536

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Microsporidial stromal keratitis is an increasingly well-known vision-threatening disease. A large proportion of cases are initially misdiagnosed as herpes simplex keratitis and treated with topical steroids. In most of such cases, medical treatment failed, and corneal transplantation was required. Read More

View Article and Full-Text PDF

Dry eye symptoms in interferon regulatory factor 3-deficient mice due to herpes simplex virus infection in harderian gland and lacrimal gland.

Exp Eye Res 2022 Jun 26;219:109053. Epub 2022 Mar 26.

Department of Ophthalmology, Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, 400042, China. Electronic address:

Purpose: Dry eye syndrome (DES) is a multifactorial ocular disorder. The possible pathogens and pathogenic mechanisms for virus-related dry eye disease are largely unknown. The current study aimed to provide evidence for mechanisms contributing to DES induced by herpes simplex virus (HSV) infection in the harderian gland (HG) and lacrimal gland (LG). Read More

View Article and Full-Text PDF

Tripartite-Motif 21 (TRIM21) Deficiency Results in a Modest Loss of Herpes Simplex Virus (HSV)-1 Surveillance in the Trigeminal Ganglia Following Cornea Infection.

Viruses 2022 03 12;14(3). Epub 2022 Mar 12.

Department of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Tripartite-motif 21 (TRIM21) is thought to regulate the type I interferon (IFN) response to virus pathogens and serve as a cytosolic Fc receptor for immunoglobulin. Since herpes simplex virus (HSV)-1 is sensitive to type I IFN and neutralizing antibody, we investigated the role of TRIM21 in response to ocular HSV-1 infection in mice. In comparison to wild type (WT) mice, TRIM21 deficient (TRIM21 KO) mice were found to be no more susceptible to ocular HSV-1 infection than WT animals, in terms of infectious virus recovered in the cornea. Read More

View Article and Full-Text PDF

Stromal and endothelial herpes simplex virus keratitis reactivation in the convalescent period of COVID-19 - A case report.

Indian J Ophthalmol 2022 04;70(4):1410-1412

Department of Glaucoma, Disha Eye Hospitals, Barrackpore, Kolkata, West Bengal, India.

A 73-year-old lady presented with a white spot and redness in the left eye for 1 month and had been treated elsewhere as a case of fungal keratitis. She had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection 2 months before. Her past ocular history and examination gave a probable diagnosis of herpetic stromal and endothelial keratitis. Read More

View Article and Full-Text PDF

Nectin-1 and Non-muscle Myosin Heavy Chain-IIB: Major Mediators of Herpes Simplex Virus-1 Entry Into Corneal Nerves.

Front Microbiol 2022 28;13:830699. Epub 2022 Feb 28.

Department of Ophthalmology, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Herpes Simplex Virus 1 (HSV-1) invades corneal nerves upon its infection of the cornea and then establishes latency in the trigeminal ganglion (TG). The latent virus in TG is often reactivated and travels back to the cornea, causing recurrent herpes simplex keratitis (HSK). The entry of HSV-1 into the corneal nerve is considered the initial step of infection resulting in HSV-1 latency and HSK recurrence. Read More

View Article and Full-Text PDF
February 2022

Evidence in the prevention of the recurrence of herpes simplex and herpes zoster keratitis after eye surgery.

Arch Soc Esp Oftalmol (Engl Ed) 2022 Mar 19;97(3):149-160. Epub 2022 Feb 19.

Vissum Grupo Miranza, Alicante, Spain. Electronic address:

Objective: Herpetic keratitis, either due to herpes simplex keratitis (HSK) or herpes zoster ophthalmicus (HZO), can recur after eye surgery.º Prophylaxis is postulated as necessary to avoid it. The objective of this study was to review the scientific evidence on the preventive methods used in the perioperative period in patients previously affected by HSK/HZO. Read More

View Article and Full-Text PDF

Herpetic uveitis caused by herpes simplex virus after cataract surgery in a patient without prior viral keratitis or uveitis: a case report.

BMC Ophthalmol 2022 Mar 5;22(1):104. Epub 2022 Mar 5.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: To report a case of herpetic uveitis caused by herpes simplex virus after cataract surgery in a patient without prior viral keratitis or uveitis.

Case Presentation: A 70-year-old female was referred to our clinic with a 16-day history of acute blurry vision with painful redness in the right eye. She accepted cataract surgery for the right eye ten days before initial of ocular symptoms. Read More

View Article and Full-Text PDF

Bilateral interstitial keratitis in a patient with presumed brain tuberculoma.

Arq Bras Oftalmol 2022 Feb 14. Epub 2022 Feb 14.

Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Interstitial keratitis is an inflammation of the corneal stroma without epithelium or endothelium involvement. The underlying causes are mostly infectious or immune mediated. Brazil has one of the highest incidence rates of tuberculosis in the world. Read More

View Article and Full-Text PDF
February 2022