4,675 results match your criteria Keratitis Herpes Simplex


Development of lacrimal gland inflammation in the mouse model of herpes stromal keratitis.

Exp Eye Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA; Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

Herpes stromal keratitis (HSK) is a chronic immunoinflammatory condition which develops in response to recurrent herpes simplex virus-1 (HSV-1) infection of the cornea. Patients with HSK often demonstrate the concurrence of corneal desiccation and the loss of blink reflex. However, the relationship between severity of HSK, level of basal tears and inflammation of the lacrimal gland is mostly unexplored. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144835193013
Publisher Site
http://dx.doi.org/10.1016/j.exer.2019.04.022DOI Listing
April 2019
1 Read

Antagonizing the glucocorticoid receptor impairs explant-induced reactivation in mice latently infected with herpes simplex virus 1.

J Virol 2019 Apr 10. Epub 2019 Apr 10.

Oklahoma State University, Center for Veterinary Health Sciences, Department of Veterinary Pathobiology, Stillwater, OK 74078

Herpes simplex virus 1 (HSV-1) establishes life-long latent infections in neurons. Reactivation from latency can lead to serious recurrent disease, including stromal keratitis, corneal scarring, blindness, and encephalitis. Although numerous studies link stress to an increase in the incidence of reactivation from latency and recurrent disease, the mechanism of action is not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00418-19DOI Listing
April 2019
1 Read

Short-term results of acellular porcine corneal stroma keratoplasty for herpes simplex keratitis.

Xenotransplantation 2019 Apr 10:e12509. Epub 2019 Apr 10.

China Regenerative Medicine International Limited, Wanchai, Hong Kong.

Background: Corneal transplantation is a common surgical intervention for restoring vision loss due to corneal damages. However, for cultural reasons, there is a huge shortage of donor corneas in China. Acellular porcine corneal stromas (APCSs) can be used as corneal substitutes in lamellar keratoplasty for corneal ulcers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12509DOI Listing
April 2019
1 Read

Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan.

Ann Rheum Dis 2019 Apr 6. Epub 2019 Apr 6.

Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan

Objective: Patients with systemic lupus erythematosus (SLE) are susceptible to herpes simplex virus (HSV) infection, which occasionally leads to severe complications including meningoencephalitis and keratitis. However, few attempts to analyse the associated incidence and risk factors have been made.

Methods: We enrolled patients with SLE recorded between 1997 and 2012 and compared the incidence rate (IR) of severe HSV infection, including meningoencephalitis, septicaemia, ocular and visceral involvement, and other specific complications demanding hospitalisation, with that of a non-SLE cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2018-214844DOI Listing
April 2019
2 Reads

The Role of T Cells in Herpes Stromal Keratitis.

Front Immunol 2019 19;10:512. Epub 2019 Mar 19.

Biomedical and Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN, United States.

The blinding inflammatory lesion stromal keratitis (SK), which occurs in some patients in response to ocular herpes simplex virus (HSV) infection, represents mainly an immune cell mediated inflammatory response to the virus infection. The principal orchestrators of the immunopathological lesions are T cells although additional events participate that include the extent of recruitment of non-lymphoid cells, the extent of neoangiogenesis, and the extent of damage to nerve function. This review focuses on evidence that the balance of the functional subsets of T cells has a major impact on lesion severity and duration. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00512
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433787PMC
March 2019
6 Reads

Corneal esthesiometry and sub-basal nerves morphological changes in herpes simplex virus keratitis/uveitis patients.

Int J Ophthalmol 2019 18;12(3):407-411. Epub 2019 Mar 18.

Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania.

Aim: To describe and compare corneal sensation and morphological changes of sub-basal corneal nerves by laser scanning confocal microscopy (LSCM) in herpes simplex virus (HSV) keratitis/uveitis and contralateral, clinically unaffected eyes.

Methods: A prospective clinical study included 30 HSV eyes and 30 contralateral eyes of 30 patients, diagnosed with unilateral HSV keratitis/uveitis. Both eyes underwent a complete ophthalmological examination, Cochet-Bonnet aesthesiometry and LSCM of the central cornea, using the Heidelberg Retina Tomograph III Rostock Cornea Module. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18240/ijo.2019.03.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423398PMC

Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice.

mSphere 2019 03 27;4(2). Epub 2019 Mar 27.

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Sex differences related to immune response and inflammation play a role in the susceptibility and pathogenesis of a variety of viral infections and disease (S. L. Klein, Bioessays 34:1050-1059, 2012, https://doi. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mSphere.00073-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437272PMC
March 2019
2 Reads

Successful Management of Herpes Simplex Keratitis With Oral Valganciclovir in Patients Unresponsive or Allergic to Conventional Antiviral Therapy.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA.

Purpose: To describe 4 cases of presumably immunocompetent patients with herpes simplex virus (HSV) keratitis unresponsive (n = 3) or allergic (n = 1) to conventional antiviral therapy that improved with oral valganciclovir treatment.

Methods: Retrospective case series of 4 patients with HSV keratitis treated with oral valganciclovir between March 2016 and June 2018.

Results: We reviewed the records of 4 patients with recurrent epithelial HSV keratitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICO.0000000000001917DOI Listing
March 2019
3 Reads

Bilateral herpes simplex keratitis: lactation a trigger for recurrence!

BMJ Case Rep 2019 Mar 9;12(3). Epub 2019 Mar 9.

Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

A young lactating woman presenting to us with simultaneous bilateral corneal lesions was clinically diagnosed to have herpes simplex keratitis, which was confirmed by herpes simplex virus (HSV) PCR. The patient was administered topical and systemic acyclovir therapy and therapeutic penetrating keratoplasty was done in right eye. She was advised to continue breast feeding under strict hygienic conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2017-223713DOI Listing
March 2019
2 Reads

Bilateral Herpes Simplex Virus-related Peripheral Ulcerative Keratitis Leading to Corneal Perforation in a Patient with Primary Herpes Simplex Virus Infection.

J Ophthalmic Vis Res 2019 Jan-Mar;14(1):93-96

Department of Ophthalmology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Purpose: To present a case of bilateral peripheral ulcerative keratitis (PUK) caused by primary herpes simplex virus-1 (HSV-1) infection resulting in corneal perforation.

Case Report: A 24-year-old man presented at the eye casualty of our clinic, with a 20-day history of severe pain, redness, photophobia, and tearing in both of his eyes. Slit-lamp examination revealed bilateral superior corneal perforation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jovr.jovr_3_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388516PMC
March 2019
2 Reads

Case Series: Pediatric Herpes Simplex Keratitis.

Authors:
Marie I Bodack

Optom Vis Sci 2019 Mar;96(3):221-226

Significance: Although the clinical appearance of pediatric ocular herpes simplex virus (HSV) is similar in children and adults, there is evidence that stromal disease and recurrences are more common in pediatric patients. Misdiagnosis of these patients is common, and patients can develop corneal scarring and amblyopia.

Purpose: This case series will review important clinical concepts on pediatric ocular HSV including differences in presentation and current treatment recommendations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/OPX.0000000000001345DOI Listing
March 2019
9 Reads

Macrodendrite in a Patient With Herpes Simplex Virus Keratitis.

JAMA Ophthalmol 2019 Feb 14;137(2):e183979. Epub 2019 Feb 14.

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia.

View Article

Download full-text PDF

Source
http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaophthalmol.2018.3979DOI Listing
February 2019
5 Reads

Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies.

Arch Soc Esp Oftalmol 2019 Apr 2;94(4):171-183. Epub 2019 Feb 2.

Departamento de Oftalmología, Hospital Ramón y Cajal, Madrid, España.

Neurotrophic keratopathy (NK) is a degenerative corneal disease caused by damage of trigeminal innervation. This leads to epithelial defects, ulceration and, eventually, perforation. Both herpes simplex and varicella zoster keratitis are reported to be the main causes of NK. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oftal.2019.01.002DOI Listing
April 2019
2 Reads

Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14191

Department of Ophthalmology and Visual Science, Daejeon St. Mary's Hospital.

Rationale: To report a case of herpes simplex virus (HSV) linear endotheliitis in a 57-year-old male who had underwent keratoplasty 10 years ago. The characteristic linear keratic precipitates (KPs) resembled the Khodadoust line in graft rejection. The differential diagnosis is essential, because the treatment regimen is different between HSV linear endotheliitis and graft rejection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370012PMC
January 2019
2 Reads

Exploring the role of programmed cell death protein 1 and its ligand 1 in eye diseases.

Crit Rev Clin Lab Sci 2019 01 3;56(1):18-32. Epub 2019 Jan 3.

a Tianjin Medical University Eye Hospital , Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin Medical University , Tianjin , China.

Programmed death receptor-1 (PD-1) and its ligand, PD-L1, as negative co-stimulatory molecules, are indispensable for regulating both physiological and pathological immune responses. The PD-1/PD-L1-mediated signaling pathway has been studied extensively in cancer research and has become a hotspot for biopharmaceuticals and immunotherapy. Furthermore, monoclonal antibodies to PD-1 have just been approved by the US Food and Drug Administration to treat certain types of malignancies. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10408363.2018.1
Publisher Site
http://dx.doi.org/10.1080/10408363.2018.1522292DOI Listing
January 2019
27 Reads

Role of Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein K (gK) Pathogenic CD8 T Cells in Exacerbation of Eye Disease.

Front Immunol 2018 7;9:2895. Epub 2018 Dec 7.

Department of Surgery, Center for Neurobiology and Vaccine Development, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

HSV-1-induced corneal scarring (CS), also broadly referred to as Herpes Stromal Keratitis (HSK), is the leading cause of infectious blindness in developed countries. It is well-established that HSK is in fact an immunopathological disease. The contribution of the potentially harmful T cell effectors that lead to CS remains an area of intense study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.02895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292954PMC
December 2018

Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors.

PLoS One 2018 28;13(11):e0208163. Epub 2018 Nov 28.

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

To investigate the clinical characteristics, treatment, risk factors of occurrence and graft transparency of corneal epithelial defects after penetrating keratoplasty in patients with infectious keratitis. 594 patients (594 eyes) with infectious keratitis treated by penetrating keratoplasty at Shandong Eye Institute were reviewed retrospectively between January 2008 and January 2018. We investigated the demographic data, diameter and sources of graft, onset time, location, scope, time of healing and treatment of epithelial defects, as well as other postoperative complications and graft clarity. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208163PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261636PMC
November 2018
14 Reads

Clinical management of herpes simplex virus infections: past, present, and future.

F1000Res 2018 31;7. Epub 2018 Oct 31.

Department of Pathobiology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.

Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Read More

View Article

Download full-text PDF

Source
https://f1000research.com/articles/7-1726/v1
Publisher Site
http://dx.doi.org/10.12688/f1000research.16157.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213787PMC
March 2019
9 Reads

Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty.

J Ophthalmol 2018 22;2018:4351460. Epub 2018 Oct 22.

Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Jinan, China.

Purpose: To observe clinical characteristics and treatment outcomes of new onset herpes simplex keratitis (HSK) after keratoplasty.

Methods: Among 1,443 patients (1,443 eyes) who underwent keratoplasty (excluding cases of primary HSK) in Shandong Eye Hospital, 17 patients suffered postoperative HSK. The clinical manifestations, treatment regimens, and prognoses of the patients were evaluated. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/joph/2018/4351460/
Publisher Site
http://dx.doi.org/10.1155/2018/4351460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217905PMC
October 2018
75 Reads

Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea.

Cell Mol Life Sci 2019 Feb 16;76(3):405-419. Epub 2018 Oct 16.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor St, Chicago, IL, 60612, USA.

Herpes simplex virus type-1 (HSV-1) is a ubiquitous pathogen that infects a large majority of the human population worldwide. It is also a leading cause of infection-related blindness in the developed world. HSV-1 infection of the cornea begins with viral entry into resident cells via a multistep process that involves interaction of viral glycoproteins and host cell surface receptors. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00018-018-2938-1
Publisher Site
http://dx.doi.org/10.1007/s00018-018-2938-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349487PMC
February 2019
36 Reads
5.810 Impact Factor

Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation.

Ocul Surf 2019 Jan 11;17(1):40-49. Epub 2018 Oct 11.

Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA.

Herpes simplex virus type 1 (HSV) keratitis is a leading cause of infectious blindness. Clinical disease occurs variably throughout the cornea from epithelium to endothelium and recurrent HSV stromal keratitis is associated with corneal scarring and neovascularization. HSV keratitis can be associated with ocular pain and subsequent neutrophic keratopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtos.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340725PMC
January 2019
7 Reads

Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence.

Korean J Ophthalmol 2018 Oct;32(5):353-360

Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea.

Purpose: To describe the clinical manifestations of herpes simplex keratitis (HSK) in a tertiary referral center in South Korea and to determine whether ascorbic acid treatment prevents recurrence of herpetic epithelial keratitis.

Methods: This retrospective cohort study included all consecutive patients with herpetic keratitis referred to our center from January 2010 to January 2015. Clinical features, ocular complications, and recurrences were recorded. Read More

View Article

Download full-text PDF

Source
https://synapse.koreamed.org/DOIx.php?id=10.3341/kjo.2017.01
Publisher Site
http://dx.doi.org/10.3341/kjo.2017.0131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182212PMC
October 2018
6 Reads

Topical cyclosporine-A versus prednisolone for herpetic stromal keratitis: a randomized controlled trial.

Acta Ophthalmol 2019 Mar 3;97(2):e194-e198. Epub 2018 Oct 3.

Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose: To compare topical cyclosporine-A 2% eye drop (Cs-A) with prednisolone acetate 1% eye drop for treatment of herpetic stromal keratitis (HSK).

Methods: In this randomized clinical trial, 38 eyes of 33 patients with HSK were randomly assigned to receive either 2% Cs-A or 1% prednisolone acetate eye drops. All subjects received oral acyclovir 400 mg twice a day. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/aos.13913
Publisher Site
http://dx.doi.org/10.1111/aos.13913DOI Listing
March 2019
4 Reads

Herpes simplex virus keratitis mimicking Acanthamoeba keratitis: a clinicopathological correlation.

BMJ Case Rep 2018 Sep 19;2018. Epub 2018 Sep 19.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York City, New York, USA.

A 36-year-old male, soft contact lens wearer was referred by his primary ophthalmologist for corneal ulcer of the right eye (OD), which was persistent despite topical fluoroquinolone therapy for 1 month. A ring-shaped infiltrate typically seen in Acanthamoeba infection was noted, and topical therapy with chlorhexidine and polyhexamethylene biguanide was initiated. However, the patient's condition deteriorated over the next several weeks; thus, diagnostic and therapeutic penetrating keratoplasty was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-226100DOI Listing
September 2018
4 Reads

A Review of the Cytokine IL-17 in Ocular Surface and Corneal Disease.

Curr Eye Res 2018 Sep 19:1-10. Epub 2018 Sep 19.

d Institute of Ophthalmology , University College London , London , England.

Aim: To investigate the role of interleukin-17 in ocular surface and corneal disease. Ocular surface and corneal disease is a leading cause of blindness and is an ongoing challenge for the public health sector to implement effective therapies. The majority of cells in corneal lesions are derived primarily from neutrophils that induce inflammatory events that lead to tissue damage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02713683.2018.1519834DOI Listing
September 2018
3 Reads

[Bilateral dendritic keratitis].

J Fr Ophtalmol 2018 Oct 11;41(8):782-783. Epub 2018 Sep 11.

Service d'ophtalmologie, CHU Bretonneau, 2, boulevard Tonnellé, 37044 Tours cedex, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfo.2018.01.018DOI Listing
October 2018

Current Practice Patterns and Opinions on the Management of Recent-Onset or Chronic Herpes Zoster Ophthalmicus of Zoster Eye Disease Study Investigators.

Cornea 2019 Jan;38(1):13-17

Department of Ophthalmology, New York University School of Medicine, New York, NY.

Purpose: To determine practices and opinions among study investigators in the Zoster Eye Disease Study (ZEDS) regarding suppressive valacyclovir treatment for recent-onset and chronic herpes zoster ophthalmicus (HZO).

Methods: An Internet-based survey was distributed to 170 ZEDS study investigators with questions regarding treatment practices for stromal keratitis in HZO and opinions regarding the efficacy of prolonged antiviral prophylaxis.

Results: The response rate was 72. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICO.0000000000001732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279559PMC
January 2019
28 Reads

[Optical coherence tomography and in vivo confocal microscopy in pseudophakic bullous keratopathy].

J Fr Ophtalmol 2018 Sep 22;41(7):682-684. Epub 2018 Aug 22.

Centre hospitalier national d'ophtalmologie des XV-XX, 28, rue de Charenton, 75571 Paris cedex 12, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfo.2017.11.031DOI Listing
September 2018

Rituximab and bilateral HSV epithelial keratitis in a patient with mucous membrane pemphigoid.

J Ophthalmic Inflamm Infect 2018 Aug 23;8(1):12. Epub 2018 Aug 23.

Department of Dermatology, University Hospital of Bern, Bern, Switzerland.

Background: B cell depleting therapy is widely used for lymphoproliferative diseases and immune-mediated disorders, including mucous membrane pemphigoid. The latter is an autoimmune blistering disease affecting predominantly the mucosae potentially associated with devastating complications.

Methods: A 71-year-old patient with severe mucous membrane pemphigoid involving ocular, oral pharyngeal and laryngeal involvement is described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12348-018-0153-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107448PMC
August 2018
2 Reads

Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions.

Mucosal Immunol 2018 11 7;11(6):1705-1715. Epub 2018 Aug 7.

Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.

This report deals with the possible mechanism by which IL-18 can contribute to the control and resolution of inflammatory lesions in the cornea caused by herpes simplex virus infection. Our results demonstrate that the expression of the IL-18R by both regulatory T cells (Treg) and effector T cells was a pivotal event that influenced lesion pathogenesis. The engagement of IL-18R on Treg with its cytokine ligand resulted in Amphiregulin expression a molecule associated with tissue repair. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41385-018-0058-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279570PMC
November 2018
1 Read

A Mutation in the Gene Abolishes Expression of the Newly Identified UL24.5 Protein of Herpes Simplex Virus 1 and Leads to an Increase in Pathogenicity in Mice.

J Virol 2018 10 26;92(20). Epub 2018 Sep 26.

INRS-Institut Armand-Frappier, Laval, Québec, Canada

Herpes simplex virus 1 (HSV-1) infects the host via epithelia and establishes latency in sensory neurons. The gene is conserved throughout the family, and the UL24 protein is important for efficient viral replication and pathogenesis. Multiple transcripts are expressed from the gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00671-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158418PMC
October 2018
13 Reads

Effect of storage time and temperature on the detection of Pseudomonas aeruginosa, Acanthamoeba and Herpes Simplex Virus from corneal impression membranes.

J Med Microbiol 2018 Sep 27;67(9):1321-1325. Epub 2018 Jul 27.

1​St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.

The effect of storage time and temperature on the recovery of pathogen DNA from polytetrafluorethylene (PTFE) was investigated. PTFE impression membranes were inoculated with Pseudomonas aeruginosa, Herpes Simplex Virus-1 (HSV-1) or Acanthamoeba and stored at -70 °C, -20 °C, +4 °C or +35 °C. PCR was performed on days 0, 1, 2, 3, 7 and months 1, 3 and 10 post-inoculation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jmm.0.000812DOI Listing
September 2018
4 Reads

Transcriptional Profile and Integrative Analyses of Long Noncoding RNAs in Primary Human Corneal Epithelial Cells in Response to HSV-1 Infection.

Curr Eye Res 2018 Dec 17;43(12):1422-1431. Epub 2018 Aug 17.

c Institute of Ophthalmology, School of Medicine , Jinan University , Guangzhou , China.

Purpose: Long noncoding RNAs (lncRNAs) have been demonstrated to have important regulatory functions in diverse cellular processes; however, the role of lncRNAs in the pathogenesis of herpes simplex keratitis (HSK) remains poorly understood.

Methods: Primary human corneal epithelial cells (HCECs) were infected with herpes simplex virus-1 (HSV-1) and the total RNAs extracted from both the infected group and the mock-infected group subjected to microarray analysis to identify the differential expression of lncRNAs and mRNAs. We also performed bioinformatic analysis including gene ontology (GO) analysis, pathway analysis and co-expression network analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02713683.2018.1504085DOI Listing
December 2018
21 Reads
1.663 Impact Factor

PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice.

Invest Ophthalmol Vis Sci 2018 06;59(7):2923-2931

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.

Purpose: The purpose of this study was to explore the effects of pigment epithelium derived factor (PEDF) and PEDF-derived peptides Mer44 and Mer34 on the severity of herpetic simplex keratitis (HSK) in mice.

Methods: Adult C57BL/6 mice were infected ocularly with the herpes simplex virus type 1 (HSV-1, McKrae strain) and injected subconjunctivally with PEDF, Mer44, or Mer34. Corneal nerve degeneration, neovascularization, sensitivity, neutrophils, macrophages and CD4+ T-cell infiltration, virus contents, and expressions of VEGF, PEDF, and proinflammatory factors were evaluated during acute period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.18-23942DOI Listing
June 2018
6 Reads
3.400 Impact Factor

Diagnosing superinfection keratitis with multiplex polymerase chain reaction.

J Infect Chemother 2018 Dec 11;24(12):1004-1008. Epub 2018 Jul 11.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Purpose: To report the potential usefulness of multiplex polymerase chain reaction (mPCR) for diagnosing superinfection keratitis caused by herpes simplex virus-1 (HSV-1), bacteria and fungus.

Methods: Case series. Corneal scrapings were analyzed with mPCR for human herpes virus 1-8, bacterial 16S ribosomal DNA (rDNA) and fungal 28S rDNA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2018.06.012DOI Listing
December 2018
25 Reads

Evaluation of the Effectiveness of Cross-Linking Combined With Photorefractive Keratectomy for Treatment of Keratoconus.

Cornea 2018 Sep;37(9):1143-1150

Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Purpose: To evaluate the effectiveness and safety of combined epithelium-off cross-linking (CXL) with photorefractive keratectomy (CXL Plus) for correction of the myopic and astigmatic components of keratoconus.

Methods: Seventy-nine eyes of 46 patients who underwent CXL Plus were enrolled in this retrospective, multicenter, noncomparative clinical study. Uncorrected distance visual acuity, corrected distance visual acuity, refraction, keratometry, and pachymetry measurements were recorded preoperatively and at 3, 6, 12, and 18 months during follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICO.0000000000001663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092093PMC
September 2018
6 Reads
2.360 Impact Factor

Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease.

J Virol 2018 09 16;92(17). Epub 2018 Aug 16.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA

We previously isolated a herpes simplex virus 1 (HSV-1) mutant, KOS-NA, that carries two nonsynonymous mutations in , resulting in L393P and R950H amino acid substitutions in infected cell protein 6 (ICP6). Our published data studying KOS-NA pathogenesis strongly suggest that one of these ICP6 substitutions expressed from KOS-NA, R950H, severely impaired acute viral replication in the eyes and trigeminal ganglia of mice after inoculation onto the cornea and consequently impaired establishment and reactivation from latency. Because of its significant neuroattenuation, we tested KOS-NA as a potential prophylactic vaccine against HSV-1 in a mouse model of corneal infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01036-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096795PMC
September 2018
13 Reads

Human Asymptomatic Epitope Peptide/CXCL10-Based Prime/Pull Vaccine Induces Herpes Simplex Virus-Specific Gamma Interferon-Positive CD107 CD8 T Cells That Infiltrate the Corneas and Trigeminal Ganglia of Humanized HLA Transgenic Rabbits and Protect against Ocular Herpes Challenge.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California, Irvine, Irvine, California, USA

Herpes simplex virus 1 (HSV-1) is a prevalent human pathogen that infects the cornea, causing potentially blinding herpetic disease. A clinical herpes vaccine is still lacking. In the present study, a novel prime/pull vaccine was tested in a human leukocyte antigen (HLA) transgenic rabbit model of ocular herpes (HLA Tg rabbits). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00535-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069188PMC
August 2018
18 Reads

Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA

During herpes simplex virus (HSV) latency, most viral genes are silenced, with the exception of one region of the genome encoding the latency-associated transcript (LAT). This long noncoding RNA was originally described as having a role in enhancing HSV-1 reactivation. However, subsequent evidence showing that the LAT blocked apoptosis and promoted efficient establishment of latency suggested that its effects on reactivation were secondary to establishment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00812-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069208PMC
August 2018
3 Reads
4.439 Impact Factor

Herpetic eye disease study: lessons learned.

Curr Opin Ophthalmol 2018 Jul;29(4):340-346

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Purpose Of Review: Ophthalmic herpes simplex virus (HSV) of the anterior segment is responsible for a range of corneal complications such as scarring, thinning, neovascularization, and severe loss of vision. This review provides current guidelines for treating anterior segment disease related to HSV.

Recent Findings: We first review findings from the Herpetic Eye Disease Study (HEDS) clinical trials, and then review new topical and antiviral therapies developed since the HEDS studies. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00055735-201807000-0001
Publisher Site
http://dx.doi.org/10.1097/ICU.0000000000000482DOI Listing
July 2018
43 Reads

On the role of retinoic acid in virus induced inflammatory response in cornea.

Microbes Infect 2018 Jun - Jul;20(6):337-345. Epub 2018 May 26.

Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, 37996, USA. Electronic address:

Ocular infection with herpes simplex virus (HSV) can result in a chronic immune inflammatory lesion that is a significant cause of human blindness. A key to controlling stromal keratitis (SK) lesion severity is to identify cellular and molecular events responsible for tissue damage and to counteract them. One potentially useful approach to achieve such therapy is Retinoic Acid (RA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micinf.2018.04.007DOI Listing
May 2018
2 Reads

Herpes zoster ophthalmicus: acute keratitis.

Authors:
Jennifer Y Li

Curr Opin Ophthalmol 2018 Jul;29(4):328-333

University of California, Davis, UC Davis Eye Center Sacramento, California, USA.

Purpose Of Review: Herpes zoster is a common condition, and involvement of the trigeminal nerve results in herpes zoster ophthalmicus (HZO). Acute keratitis is one of the most common of these ocular complications associated with HZO. The findings associated with and the management of acute zoster keratitis will be reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICU.0000000000000491DOI Listing
July 2018
3 Reads

Management of Herpes Simplex Virus Keratitis in the Pediatric Population.

Pediatr Infect Dis J 2018 09;37(9):949-951

From the Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD.

Herpes simplex virus (HSV) keratitis is a highly prevalent and visually disabling disease in both the pediatric and adult population. While many studies have investigated the treatment of HSV keratitis in adult patients, few have focused on managing this condition in children. Children are at particularly high risk for visual morbidity due to unique challenges in diagnosis and treatment, and the often more aggressive disease course that results in corneal scarring, and subsequently amblyopia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/INF.0000000000002114DOI Listing
September 2018
7 Reads

Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis.

Clin Exp Ophthalmol 2018 Dec 30;46(9):1008-1016. Epub 2018 May 30.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

Importance: To standardize initial anti-viral therapy for herpes simplex keratitis (HSK).

Background: To determine prescribing trends for the management of HSK and compare the trends to available clinical trial evidence.

Design: Retrospective review of patients at the Sydney Eye Hospital, Australia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ceo.13319DOI Listing
December 2018
7 Reads

Surgical management of herpetic keratitis.

Curr Opin Ophthalmol 2018 Jul;29(4):347-354

Department of Ophthalmology, University of Florida, Gainesville, Florida, USA.

Purpose Of Review: The purpose of this review is to discuss the options for, and recent developments in, the surgical treatment of herpes keratitis. Although the mainstay of treatment of herpetic keratitis is topical or oral antiviral agents, surgical intervention may be necessary for corneal melting or long-term complications such as scarring, lipid keratopathy, necrotizing keratitis, and neurotrophic keratitis.

Recent Findings: There are a number of surgical therapies available for herpes keratitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICU.0000000000000484DOI Listing
July 2018
5 Reads

Management of herpes simplex virus epithelial keratitis.

Curr Opin Ophthalmol 2018 Jul;29(4):360-364

Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Purpose Of Review: To review recent advancements in the management of herpes simplex virus (HSV) epithelial keratitis.

Recent Findings: Trifluridine eye drop, acyclovir (ACV) ointment, ganciclovir gel, and oral ACV are still the main therapeutic agents. Cryopreserved amniotic membrane has been recently used as an adjuvant treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICU.0000000000000483DOI Listing
July 2018
6 Reads

Bilateral herpes simplex keratitis reactivation after lacrimal gland botulinum toxin injection.

Indian J Ophthalmol 2018 05;66(5):697-699

Cornea Services, LJ Eye Institute, Ambala, Haryana, India.

Botulinum toxin A (BTA) injections into lacrimal gland are being used for refractory epiphora due to intractable lacrimal disorders with success rates reported from 18% to 86%. Most common side effects are transient ptosis and diplopia. We report a case of a 59-year-old female injected with 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijo.IJO_904_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939169PMC
May 2018
12 Reads

[Uveitis treated with biotherapy and/or DMARD: Analysis from the French Pharmacovigilance Study Base].

J Fr Ophtalmol 2018 Apr 13;41(4):350-356. Epub 2018 Apr 13.

Service de rhumatologie, hôpital Pasteur 2, CHU de Nice, 30, voie Romaine, CS 51069, 06001 Nice cedex 1, France. Electronic address:

Purpose: To report the characteristics of uveitis cases occurring while on biologic therapy or disease-modifying antirheumatic drugs (DMARDs) reported to the French national pharmacovigilance database.

Methods: All the uveitis cases occurring in patients with chronic rheumatologic diseases, chronic inflammatory intestinal diseases or connective tissue diseases, while treated with DMARDs and/or biologic therapies between 2000 and 2015 and reported to the French National Pharmacovigilance Database were collected.

Results: During the study period, 32 cases of uveitis were reported (15 men, 17 women). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfo.2017.11.012DOI Listing
April 2018
1 Read

Epithelial Keratitis After Cataract Surgery.

Cornea 2018 Jun;37(6):755-759

Department of Ophthalmology, University of Utah College of Medicine, Salt Lake City, UT.

Purpose: To evaluate the incidence, related perioperative factors, clinical characteristics, and possible etiologies of epithelial keratitis after cataract surgery.

Methods: A retrospective chart review of 666 eyes in 666 patients who underwent cataract surgery was performed to evaluate the incidence of epithelial keratitis and related factors in the postoperative period.

Results: Postoperative epithelial keratitis developed in 15 eyes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICO.0000000000001592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376864PMC
June 2018
19 Reads

Improvement of chronic corneal opacity in ocular surface disease with prosthetic replacement of the ocular surface ecosystem (PROSE) treatment.

Am J Ophthalmol Case Rep 2018 Jun 15;10:108-113. Epub 2018 Feb 15.

BostonSight, 464 Hillside Ave, Suite 205, Needham, MA, 02494, United States.

Purpose: To demonstrate clearing of chronic corneal opacities and improvement of visual acuity with the use of BostonSight prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in ocular surface disease.

Observations: We undertook retrospective analysis of the medical records of a series of patients who underwent PROSE treatment from August 2006 to December 2014. Patients were referred for ocular surface disease of various etiologies. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24519936173016
Publisher Site
http://dx.doi.org/10.1016/j.ajoc.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852325PMC
June 2018
2 Reads