24,071 results match your criteria Keratitis Herpes Simplex


Microbial keratitis complicated by acute hydrops following corneal collagen cross-linking for keratoconus.

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, The James Cook University Hospital, Middlesbrough, UK.

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December 2018

Diagnosis, Clinical Trend, and Treatment of Diffuse Lamellar Keratitis after Femtosecond Laser-Assisted in situ Keratomileusis: A Case Report.

Case Rep Ophthalmol 2018 Sep-Dec;9(3):457-464. Epub 2018 Nov 14.

Balestrazzi Associated Ophthalmological Practice, Rome, Italy.

We report a severe case of diffuse lamellar keratitis (DLK) following femtosecond laser-assisted in situ keratomileusis (femto-LASIK). A 25-year-old man was submitted to 150 kHz iFS® IntraLase-assisted LASIK in both eyes for compound myopic astigmatism. The day after surgery, clinical examination showed a diffuse whitish granular cell reaction particularly in the right eye. Read More

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November 2018
5 Reads

A presentation of culture-positive corneal donors and the effect on clinical outcomes.

Graefes Arch Clin Exp Ophthalmol 2018 Nov 30. Epub 2018 Nov 30.

Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.

Purpose: Donor-to-host transmission of infectious agents is a rare but well-recognised complication of corneal transplantation and may carry a grave visual prognosis. In this case series, we describe the clinical features and risk factors of using culture-positive donor corneas for transplantation.

Methods: Retrospective chart review of a series of patients who underwent either penetrating keratoplasty (PK) or Descemet's stripping automated endothelial keratoplasty (DSAEK) with positive microbiology cultivation during routine assessment of donor corneal tissue obtained at the time of surgery. Read More

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November 2018

keratitis in a patient with neurotrophic keratopathy and severe neurosensory hypoacusis: Treatment with penetrating keratoplasty and amniotic membrane grafting.

Oman J Ophthalmol 2018 Sep-Dec;11(3):291-293

Department of Anatomic pathology, Hospital Provincial de Castellón, Castellón de la Plana, Castellón, Spain.

We describe a case of a man with neurotrophic keratitis of unknown ethiology, who developed a massive stromal melting during treatment of a persistent epithelial defect. A tectonic keratoplasty combined with amniotic membrane grafting was made. Host cornea specimen was analyzed, and Sphingomonas paucimobilis was isolated. Read More

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December 2018

The epidemiology of nonviral microbial keratitis in a tertiary care center in Muscat, Oman.

Oman J Ophthalmol 2018 Sep-Dec;11(3):213-219

Department of Ophthalmology, Al-Nahdah Hospital, Muscat, Oman.

Objective: The objective of this study is to describe the epidemiology, risk factors, etiology, and outcome of microbial keratitis in a tertiary care center in Muscat, Oman.

Methods: The electronic records of all patients diagnosed with keratitis or corneal ulcer between January 2013 and January 2016 in Al-Nahdha Hospital were retrospectively reviewed. Patients who presented with a corneal ulcer requiring admission and who underwent culture and sensitivity studies were included in the study. Read More

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December 2018

Analysis of penetrating keratoplasty in Northern Alberta, Canada, from 2000 to 2015.

Can J Ophthalmol 2018 Dec 10;53(6):568-573. Epub 2018 Apr 10.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address:

Objective: To study indications for penetrating keratoplasty (PK) at a single site. The trends in the causative organisms for infectious keratitis requiring surgery were also evaluated.

Design: Retrospective observational study. Read More

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December 2018

Riboflavin-induced Type 1 photo-oxidation of tryptophan using a high intensity 365 nm light emitting diode.

Free Radic Biol Med 2018 Nov 28. Epub 2018 Nov 28.

Pontificia Universidad Católica de Chile(,) Facultad de Química, Departamento de Química Física, Santiago, Chile. Electronic address:

The mechanism of photo-oxidation of tryptophan (Trp) sensitized by riboflavin (RF) was examined employing high concentrations of Trp and RF, with a high intensity 365 nm light emitting diode (LED) source under N, 20% and 100% O atmospheres. Dimerization of Trp was a major pathway under the N atmosphere, though this occurred with a low yield (φ = 5.9 x 10), probably as a result of extensive back electron transfer reactions between RF and Trp(H). Read More

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November 2018

Phacoemulsification with coexisting corneal opacities.

J Cataract Refract Surg 2018 Nov 30. Epub 2018 Nov 30.

From the Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

The treatment of choice for cases of corneal opacity with significant cataract is often a triple procedure. However, in certain situations the chances of graft survival are poor, for example in cases with deep vascularization, secondary glaucoma, and healed viral keratitis. Under these circumstances, performing cataract surgery only might improve the visual acuity enough to maintain the patient's day-to-day activities. Read More

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November 2018

[Use of the autologous dorsal dermis in reconstruction of the posterior palpebral lamella in blepharopoiesis].

Ann Chir Plast Esthet 2018 Nov 30. Epub 2018 Nov 30.

Département de chirurgie plastique, reconstructrice, brûlés, plaies et cicatrisation, CHU Lapeyronie, 371, avenue de Doyen Gaston Giraud, 34295 Montpellier, France. Electronic address:

Objectives: Blepharopoiesis represents a double aesthetic and functional challenge. If anterior lamellar reconstruction is less discussed, the variety of posterior lamellar substitutes testifies that none is ideal. We report here our experience of the use of autologous dermal dermis as posterior lamellar substitutes in bilamellar blepharopoiesis. Read More

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November 2018

Incidence of and risk factors for secondary ocular hypertension in moderate to severe infectious ulcerative keratitis.

Clin Ophthalmol 2018 24;12:2121-2128. Epub 2018 Oct 24.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand,

Purpose: The aim of this study was to investigate the incidence of and risk factors for secondary ocular hypertension (OHT) in patients with moderate to severe infectious ulcerative keratitis and to evaluate the long-term outcome of patients with secondary OHT.

Patients And Methods: A retrospective chart review of 346 patients with moderate to severe infectious keratitis admitted to Siriraj Hospital during the period from 1 January 2005 to 31 May 2008 was conducted. Secondary OHT was defined as intraocular pressure (IOP) greater than 21 mmHg or a consistent demonstration of higher IOP in the affected eye of 8 mmHg or greater, at any time before resolution of the ulcer. Read More

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October 2018

Neocucurbitaria keratinophila: An emerging opportunistic fungus causing superficial mycosis in Spain.

Med Mycol 2018 Nov 29. Epub 2018 Nov 29.

Mycology Unit, Medical School and IISPV, University Rovira i Virgili, C/ Sant Llorenç 21, 43201 Reus, Spain.

Although there have been few reports of opportunistic infections (superficial and systemic) caused by coelomycetous fungi, they are becoming more frequent. Neocucurbitaria keratinophila (formerly Pyrenochaeta keratinophila), characterized by producing pycnidial conidiomata and small hyaline conidia, seems to be an emergent opportunistic pathogen in Spain. Since this fungus was first reported from human keratitis, eight strains have been isolates from clinical cases in Spain. Read More

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November 2018
1 Read

Emergency management: microbial keratitis.

Community Eye Health 2018 ;31(103):66-67

Professor of International Eye Health: International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, UK.

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January 2018

Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors.

PLoS One 2018 28;13(11):e0208163. Epub 2018 Nov 28.

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

To investigate the clinical characteristics, treatment, risk factors of occurrence and graft transparency of corneal epithelial defects after penetrating keratoplasty in patients with infectious keratitis. 594 patients (594 eyes) with infectious keratitis treated by penetrating keratoplasty at Shandong Eye Institute were reviewed retrospectively between January 2008 and January 2018. We investigated the demographic data, diameter and sources of graft, onset time, location, scope, time of healing and treatment of epithelial defects, as well as other postoperative complications and graft clarity. Read More

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November 2018
2 Reads

Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections.

J Ocul Pharmacol Ther 2018 Nov 8. Epub 2018 Nov 8.

1 Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi , Oxford, Mississippi.

Polyenes and azoles constitute 2 major drug classes in the antifungal armamentarium used to treat fungal infections of the eye such as fungal keratitis, endophthalmitis, conjunctivitis, and blepharitis. These classes of drugs have come to occupy an important niche in ophthalmic antifungal therapy due to their broad spectrum of activity against a variety of filamentous and yeast-like fungi. Natamycin suspension (Natacyn), a polyene antifungal drug, is currently the only US FDA-approved formulation for treating ophthalmic fungal infections, whereas the other polyene and azole antifungals such as amphotericin B, fluconazole, itraconazole, ketoconazole, miconazole, voriconazole, and posaconazole are routinely used off-label in the clinical setting. Read More

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November 2018
2 Reads

Caprine Model to Study Virulence Factors in Keratitis.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):383-391

Department of Microbiology and Biotechnology Centre, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.

Purpose: To develop an infectious keratitis model using caprine (goat) corneas and to investigate the expression of virulence factors during infection.

Methods: Goat eyes were surface-sterilized and dissected, and the corneas were placed on an agarose-gelatin solid support (0.5% in phosphate-buffered saline) in a 12-well culture plate containing 10% fetal bovine serum-supplemented culture medium for 3 weeks. Read More

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November 2018
1 Read

Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii.

Parasit Vectors 2018 Nov 26;11(1):604. Epub 2018 Nov 26.

Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.

Background: Acanthamoeba spp. can cause serious human infections, including Acanthamoeba keratitis, granulomatous amoebic encephalitis and cutaneous acanthamoebiasis. Cysteine biosynthesis and the L-serine metabolic pathway play important roles in the energy metabolism of Acanthamoeba spp. Read More

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November 2018
1 Read

Orthokeratology for the Prevention of Myopic Progression in Children A report by the American Academy of Ophthalmology.

Ophthalmology 2018 Nov 23. Epub 2018 Nov 23.

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California.

Objective: To review the published evidence to evaluate the ability of orthokeratology (Ortho-K) treatment to reduce myopic progression in children and adolescents compared with the use of spectacles or daytime contact lenses for standard refractive correction.

Methods: Literature searches of the PubMed database, the Cochrane Library, and the databases of clinical trials were last conducted on May 23, 2017 with no date restrictions but limited to articles published in English. These searches yielded 162 citations, of which 13 were deemed clinically relevant for full-text review and inclusion in this assessment. Read More

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November 2018
2 Reads

An unusual case of post-cochlear implant performance degradation in a patient with suspected Cogan's syndrome.

Cochlear Implants Int 2018 Nov 24:1-6. Epub 2018 Nov 24.

d KK Children's & Women's Hospital , Singapore.

Cogan's Syndrome is an autoimmune disorder that can affect the ear, eye and other organs. Although rare, Cogan's Syndrome is particularly relevant to the cochlear implant surgeon because the resulting hearing loss is often bilateral and the majority of cases progresses to profound levels where cochlear implantation may be indicated. There are many issues relating to this condition that concern the cochlear implant surgeon. Read More

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November 2018
3 Reads

Ulcerative keratitis due to Kocuria palustris: An emerging pathogen.

Enferm Infecc Microbiol Clin 2018 Nov 22. Epub 2018 Nov 22.

Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Faculty of Medicine, Ludwig Maximilian University, Munich, Germany.

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November 2018

Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome.

Exp Parasitol 2018 Nov 22. Epub 2018 Nov 22.

University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Island, Spain.

Acanthamoeba keratitis (AK) is a sight-threatening corneal infection. The early symptoms include redness, pain, photophobia and intense tearing. Chronic infection usually progresses to stromal inflammation, ring ulcers, corneal opacification and hypopyon. Read More

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November 2018

Corneal neurotisation by great auricular nerve transfer and scleral-corneal tunnel incisions for neurotrophic keratopathy.

Br J Ophthalmol 2018 Nov 23. Epub 2018 Nov 23.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, USA.

Background/aims: Medical management of neurotrophickeratopathy is challenging and costly. Supra-orbital nerve transfer to thecornea has proven effective for management of keratopathy, but yieldsconsiderable donor site morbidity. Herein, a novel technique for reinnervationof the anaesthetic cornea is presented and early results characterised. Read More

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November 2018
2 Reads

Clinical presentations, management outcomes, and diagnostic dilemma in Kocuria endophthalmitis.

J Ophthalmic Inflamm Infect 2018 Nov 20;8(1):21. Epub 2018 Nov 20.

Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, 500034, India.

Aim: To describe the clinical presentations and management outcomes of Kocuria endophthalmitis and discuss diagnostic dilemmas DESIGN: Retrospective interventional comparative case series INTERVENTION: Eight unilateral cases with culture-proven Kocuria endophthalmitis from January 2013 to December 2017 underwent vitrectomy/vitreous biopsy and intravitreal antibiotic with or without additional procedures. The undiluted vitreous was subjected to microbiologic evaluation.

Main Outcome Measures: The mean age at presentation, etiology, number of interventions, interval between inciting event and presentation, type of intravitreal antibiotic used, and anatomic and functional outcomes were reported. Read More

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November 2018
1 Read

Ocular Surface Disease in Birds.

Authors:
Angela Griggs

Vet Clin North Am Exot Anim Pract 2019 Jan;22(1):53-68

North Houston Veterinary Ophthalmology, 1646 Spring Cypress Road, Suite 116, Spring, TX 77388, USA. Electronic address:

Avian ocular disease may be primary or a manifestation of systemic disease. Various infectious and noninfectious diseases have been reported to cause ocular pathology. Thorough physical examination and diagnostic testing are necessary to determine a treatment plan. Read More

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January 2019

Ocular Surface Disease of Rabbits.

Vet Clin North Am Exot Anim Pract 2019 Jan;22(1):1-14

Comparative Ophthalmology, University of Georgia, 2200 College Station Road, Athens, GA 30202, USA. Electronic address:

Rabbits have become a popular house pet that is encountered with increasing frequency in small animal veterinary practice. The unique anatomy of the rabbit predisposes them to developing surface ocular problems including the development of dacryocystitis, as well as conjunctivitis and keratitis. This article endeavors to give an updated outline of the various conditions affecting the rabbit ocular surface, with emphasis on diagnosis and treatment. Read More

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January 2019

Identification of hypocrealean reptile pathogenic isolates with MALDI-TOF MS.

Med Mycol 2018 Nov 16. Epub 2018 Nov 16.

Clinic for Birds and Reptiles, University of Leipzig, Leipzig, Germany.

Biotyper analysis of Nannizziopsis guarroi, a fatal fungal pathogen in lizards, was described recently. Hypocrealean fungal infections in captive reptiles appear with an increasing frequency during the last decade. Therefore, the aim of this study was to proof Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) as diagnostic tool for the identification of reptile pathogenic hypocrealean fungi. Read More

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November 2018

SPINT2 (HAI-2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI-2 to inhibit prostasin but not matriptase.

Hum Mol Genet 2018 Nov 15. Epub 2018 Nov 15.

Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.

The syndromic form of congenital sodium diarrhea (SCSD) is caused by bi-allelic mutations in SPINT2, which encodes a Kunitz type serine protease inhibitor (HAI-2). We report three novel SCSD patients, two novel SPINT2 mutations, and review published cases. The most common findings in SCSD patients were choanal atresia (20/34), and keratitis of infantile onset (26/34). Read More

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November 2018
4 Reads

Clinical management of herpes simplex virus infections: past, present, and future.

F1000Res 2018 31;7. Epub 2018 Oct 31.

Department of Pathobiology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.

Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Read More

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October 2018
3 Reads

A novel murine model for contact lens wear reveals clandestine IL-1R dependent corneal parainflammation and susceptibility to microbial keratitis upon inoculation with Pseudomonas aeruginosa.

Ocul Surf 2018 Nov 12. Epub 2018 Nov 12.

School of Optometry, University of California, Berkeley, CA, 94720, USA; Graduate Group in Vision Science, University of California, Berkeley, CA, 94720, USA; Graduate Groups in Microbiology, Infectious Diseases & Immunity, University of California, Berkeley, CA, 94720, USA. Electronic address:

Purpose: Contact lens wear carries a risk of complications, including corneal infection. Solving these complications has been hindered by limitations of existing animal models. Here, we report development of a new murine model of contact lens wear. Read More

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November 2018
8 Reads

Incidence and Outcomes of Sterile Multifocal Inflammatory Keratitis and Diffuse Lamellar Keratitis After SMILE.

J Refract Surg 2018 Nov;34(11):751-759

Purpose: To report the incidence outcomes of sterile multifocal inflammatory keratitis and diffuse lamellar keratitis (DLK) after small incision lenticule extraction (SMILE) in a large population.

Methods: This was a retrospective review of a population of 4,000 consecutive eyes treated by SMILE at the London Vision Clinic using the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany). The inclusion criterion was to have presented with inflammatory keratitis after SMILE. Read More

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November 2018
2 Reads

Recurrent PAX 6 mutation in a Chinese family with congenital aniridia, progressive cataracts and mental retardation.

Eur J Ophthalmol 2018 Nov 14:1120672118810998. Epub 2018 Nov 14.

1 Beijing Tongren Eye Center, Beijing Keynote Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background:: One prominent pathological feature of congenital aniridia is hypoplasia of the iris, often accompanied by other eye abnormalities. The objective of this study is to identify gene mutations responsible for autosomal dominance in a Chinese family with congenital aniridia, progressive cataracts and mental retardation.

Methods:: A total of 11 family members, including 6 affected and 5 unaffected individuals were recruited. Read More

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November 2018
1 Read

Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty.

J Ophthalmol 2018 22;2018:4351460. Epub 2018 Oct 22.

Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Jinan, China.

Purpose: To observe clinical characteristics and treatment outcomes of new onset herpes simplex keratitis (HSK) after keratoplasty.

Methods: Among 1,443 patients (1,443 eyes) who underwent keratoplasty (excluding cases of primary HSK) in Shandong Eye Hospital, 17 patients suffered postoperative HSK. The clinical manifestations, treatment regimens, and prognoses of the patients were evaluated. Read More

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October 2018
21 Reads

Identification and antifungal sensitivity of two new species of Diaporthe isolated.

J Infect Chemother 2018 Nov 10. Epub 2018 Nov 10.

Faculty of Agriculture and Life Science, Hirosaki University, Aomori, Japan.

Diaporhte species are plant pathogens rarely involved in human diseases, especially eye diseases. We report our findings in two undescribed Diaporhte species. Both were identified by their morphological characteristics and by DNA sequence analyses. Read More

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November 2018
1 Read

Efficacy of Luliconazole Against Broad-Range Filamentous Fungi Including Fusarium solani Species Complex Causing Fungal Keratitis.

Cornea 2018 Nov 12. Epub 2018 Nov 12.

Department of Ophthalmology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Purpose: Fungal keratitis can be difficult to medically treat. Topical antifungals are usually applied empirically as the initial option in treating fungal keratitis. Natamycin (NAT) and/or voriconazole (VRCZ) have been widely used in the treatment of fungal keratitis. Read More

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November 2018
3 Reads

Microbiological Evaluation of Bandage Soft Contact Lenses Used in Management of Persistent Corneal Epithelial Defects.

Cornea 2018 Nov 12. Epub 2018 Nov 12.

Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To investigate the rate and agents of contamination in bandage soft contact lenses fitted for management of persistent corneal epithelial defects.

Methods: This prospective comparative case series enrolled 57 consecutive eyes fitted with bandage contact lenses for treatment of persistent corneal epithelial defects. The lenses were collected at the time of epithelial closure or when it was necessary to exchange contact lenses and were immediately placed in sterile tubes containing an enriched thioglycolate liquid medium. Read More

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November 2018
3 Reads

Development of a broad-spectrum antimicrobial combination for the treatment of and corneal infections.

Antimicrob Agents Chemother 2018 Nov 12. Epub 2018 Nov 12.

Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY

and are two of the most common causes of bacterial keratitis and corresponding corneal blindness. Accordingly, such infections are predominantly treated with broad spectrum fourth generation fluoroquinolones, such as moxifloxacin. Yet rising fluoroquinolone resistance has necessitated the development of alternative therapeutic options. Read More

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November 2018
3 Reads

Bilateral Ulcerative Keratitis Associated With Afatinib Treatment for Non-Small-Cell Lung Carcinoma.

Cornea 2018 Nov 8. Epub 2018 Nov 8.

Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, NHS Trust, East Grinstead, West Sussex, United Kingdom.

Purpose: To report a case of afatinib-related bilateral ulcerative keratitis.

Methods: An 85-year-old female patient on treatment with afatinib for non-small-cell lung carcinoma presented with progressive redness, pain, and decreased vision in both eyes. Four weeks before the onset of symptoms, afatinib therapy had been commenced at a dose of 40 mg, once daily. Read More

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November 2018
3 Reads

Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes).

J Feline Med Surg 2018 Nov 12:1098612X18810867. Epub 2018 Nov 12.

1 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

Objectives: The aim of this study was to describe the clinical findings, diagnostic test results and response to therapy of cats with Schirmer tear test 1 (STT-1) values below the reference interval.

Methods: The medical records of three institutions were searched for cats with ocular surface disease and STT-1 values <9 mm/min, confirmed at two or more separate visits.

Results: Ten cats (17 eyes) were included. Read More

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November 2018

Hand hygiene is linked to microbial keratitis and corneal inflammatory events.

Cont Lens Anterior Eye 2018 Nov 7. Epub 2018 Nov 7.

Centre for Ocular Research and Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, Canada. Electronic address:

Lack of or inadequate hand washing is a risk factor in the development of contact lens related microbial keratitis and corneal inflammatory events. In the public health domain there is compelling evidence that proper hand washing with soap can save lives. The purpose of this review is to draw attention to some of the public health literature in support of hand washing and how education can influence patients' hand hygiene behavior. Read More

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November 2018
5 Reads

Pharmaceutical Approval Update.

P T 2018 Nov;43(11):659-661

Arakoda (tafenoquine) for malaria; Annovera (segesterone acetate and ethinyl estradiol vaginal system) for contraception; and Oxervate (cenegermin-bkbj) for neurotrophic keratitis. Read More

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November 2018
1 Read

HMGB1 Antagonist, Box A, Reduces TLR4, RAGE, and Inflammatory Cytokines in the Cornea of P. aeruginosa-Infected Mice.

J Ocul Pharmacol Ther 2018 Nov 8. Epub 2018 Nov 8.

1 Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine , Detroit, Michigan.

Purpose: High mobility group box 1 (HMGB1) contributes to adverse disease outcome in Pseudomonas aeruginosa keratitis. This study tests Box A, an HMGB1 antagonist, in a model of the disease.

Methods: C57BL/6 mice (B6) were injected subconjunctivally (1 day before infection) with Box A or phosphate-buffered saline (PBS), infected with P. Read More

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November 2018
3 Reads

[Contact lens complications : Diagnosis and treatment].

Ophthalmologe 2018 Dec;115(12):1087-1102

Praxis und Expert-Institut, Gammertinger Str. 33, 88499, Riedlingen, Deutschland.

Contact lens complications are all pathological alterations of the eyes caused by wearing contact lenses. Clinical manifestations particularly affect the cornea and conjunctiva. A differentiation is made between undesired manifestations and disease conditions that at least temporarily make the further wearing of contact lenses impossible. Read More

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December 2018
2 Reads

Correlation between pathogenic species and clinical findings, disease severity, and visual outcome in patients with fungal keratitis.

Arq Bras Oftalmol 2018 Nov 1. Epub 2018 Nov 1.

Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade Estadual de São Paulo, Ribeirão Preto, SP, Brazil.

Purpose: To determine whether a correlation exists between pathogenic species and clinical findings, disease severity, and visual outcome in patients with keratitis and fungal growth in microbiological culture.

Methods: A retrospective study of patients with fungal growth in the microbiological culture of corneal scrapings. Patients were treated at an ophthalmologic reference center in Southeastern Brazil from January 1992 to October 2015. Read More

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November 2018
5 Reads

Corneal targeted Sertaconazole nitrate loaded cubosomes: Preparation, statistical optimization, in vitro characterization, ex vivo permeation and in vivo studies.

Int J Pharm 2018 Dec 26;553(1-2):386-397. Epub 2018 Oct 26.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy Cairo University, Kasr El Einy St., 11562 Cairo, Egypt.

Sertaconazole nitrate (STZ) is a poorly soluble antifungal drug commonly used for treating fungal skin infections. Introducing it as a new treatment option for the management of fungal keratitis, requires the development of a delivery system capable of targeting the infected cornea with an adequate STZ concentration. Hence, Sertaconazole nitrate loaded cubosomes (STZ-CUBs) were prepared, characterized and optimized based on a 3 central composite face-centred design. Read More

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December 2018
13 Reads

The burden of serious fungal disease in the UK - infections with "rare" organisms.

J Infect 2018 Oct 31. Epub 2018 Oct 31.

PHE UK National Mycology Reference Laboratory, Science Quarter, Southmead Hospital, Bristol, United Kingdom.

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October 2018
1 Read

Contact lens wear and the diabetic corneal epithelium: A happy or disastrous marriage?

J Diabetes Complications 2018 Sep 27. Epub 2018 Sep 27.

The Department of Ophthalmology, The University of Texas Southwestern Medical Center, United States of America. Electronic address:

Diabetes mellitus is an epidemic in the US and abroad. With the advent of new contact lens technology, the use of contact lenses as glucose sensors in lieu of the traditional finger stick is quickly becoming realized. This has the potential to rapidly expand the contact lens market into this growing patient population. Read More

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September 2018
2 Reads

Persistence of Efficacy of 0.1% Cyclosporin A Cationic Emulsion in Subjects with Severe Keratitis Due to Dry Eye Disease: A Nonrandomized, Open-label Extension of the SANSIKA Study.

Clin Ther 2018 Nov 30;40(11):1894-1906. Epub 2018 Oct 30.

Quinze-Vingts National Ophthalmology Hospital, Paris, France; UPMC University, Paris 6, Vision Institute, INSERM UMRS968, CNRS UMR7210, Paris, France; University of Versailles Saint-Quentin en Yvelines, Versailles, France.

Purpose: Results from a 6-month double-masked and a 6-month open-label study (SANSIKA) established the efficacy and safety of once-daily 0.1% cyclosporin A cationic emulsion (CsA CE) in severe keratitis due to dry eye disease (DED). This article presents results from the Post-SANSIKA study, a 24-month extension of SANSIKA assessing the sustained efficacy of CsA CE after treatment discontinuation. Read More

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November 2018
2 Reads

Box Behnken design of siRNA-loaded liposomes for the treatment of a murine model of ocular keratitis caused by Acanthamoeba.

Colloids Surf B Biointerfaces 2018 Oct 18;173:725-732. Epub 2018 Oct 18.

Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:

Acanthamoeba keratitis is an ophthalmic disease with no specific treatment that specially affects contact lens users. The silencing of serine phosphatase (SP) and glycogen phosphorylase (GP) proteins produced by Acanthamoeba has been shown to significantly reduce the cytopathic effect, although no vehicle was proposed yet to deliver the siRNA sequences to the trophozoites. In this study, PEGylated cationic liposomes were proposed and optimized using Box-Behnken design. Read More

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October 2018
3 Reads

Infectious keratitis: microbiological review of 297 cases.

Jpn J Infect Dis 2018 Oct 31. Epub 2018 Oct 31.

Section of Microbiology. University Hospital of Guadalajara.

Infectious keratitis is a serious ocular infection that can lead to loss of vision. The aim of the study was to investigate the microbiological characteristics of this infection at the University Hospital of Guadalajara (Spain). We retrospectively reviewed all cases diagnosed between January 2010 and December 2016. Read More

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October 2018
1 Read

Ocular Surface Stem Cell Transplantation for Treatment of Keratitis-Ichthyosis-Deafness Syndrome.

Cornea 2019 Jan;38(1):123-126

Department of Ophthalmology, Cincinnati Eye Institute, University of Cincinnati, Cincinnati, OH.

Purpose: To report our surgical experience with ocular surface stem cell transplantation (OSST) for limbal stem cell deficiency (LSCD) in the setting of keratitis-ichthyosis-deafness (KID) syndrome.

Methods: Retrospective interventional case series.

Results: We present 5 eyes of 3 patients with KID syndrome that developed LSCD and underwent OSST. Read More

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January 2019
7 Reads

Identification of Moraxella lacunata from pulmonary abscesses in three zoo herbivores.

J Vet Med Sci 2018 Oct 29. Epub 2018 Oct 29.

College of Veterinary Medicine, Kyungpook National University.

Although Moraxella lacunata causes conjunctivitis, keratitis, endocarditis, and otolaryngitis in humans, its infection is rare in animals. We report three cases of asymptomatic pulmonary abscesses caused by M. lacunata in zoo herbivores, including two elks (Cervus canadensis) and a common eland (Taurotragus oryx). Read More

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October 2018
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