4,657 results match your criteria Keratitis Herpes Simplex


Macrodendrite in a Patient With Herpes Simplex Virus Keratitis.

JAMA Ophthalmol 2019 Feb 14;137(2):e183979. Epub 2019 Feb 14.

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamaophthalmol.2018.3979DOI Listing
February 2019

Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies.

Arch Soc Esp Oftalmol 2019 Feb 1. Epub 2019 Feb 1.

Departamento de Oftalmología, Hospital Ramón y Cajal, Madrid, España.

Neurotrophic keratopathy (NK) is a degenerative corneal disease caused by damage of trigeminal innervation. This leads to epithelial defects, ulceration and, eventually, perforation. Both herpes simplex and varicella zoster keratitis are reported to be the main causes of NK. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.01.002DOI Listing
February 2019
1 Read

Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14191

Department of Ophthalmology and Visual Science, Daejeon St. Mary's Hospital.

Rationale: To report a case of herpes simplex virus (HSV) linear endotheliitis in a 57-year-old male who had underwent keratoplasty 10 years ago. The characteristic linear keratic precipitates (KPs) resembled the Khodadoust line in graft rejection. The differential diagnosis is essential, because the treatment regimen is different between HSV linear endotheliitis and graft rejection. Read More

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http://dx.doi.org/10.1097/MD.0000000000014191DOI Listing
January 2019
1 Read

Exploring the role of programmed cell death protein 1 and its ligand 1 in eye diseases.

Crit Rev Clin Lab Sci 2019 Jan 3;56(1):18-32. Epub 2019 Jan 3.

a Tianjin Medical University Eye Hospital , Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin Medical University , Tianjin , China.

Programmed death receptor-1 (PD-1) and its ligand, PD-L1, as negative co-stimulatory molecules, are indispensable for regulating both physiological and pathological immune responses. The PD-1/PD-L1-mediated signaling pathway has been studied extensively in cancer research and has become a hotspot for biopharmaceuticals and immunotherapy. Furthermore, monoclonal antibodies to PD-1 have just been approved by the US Food and Drug Administration to treat certain types of malignancies. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408363.2018.1
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http://dx.doi.org/10.1080/10408363.2018.1522292DOI Listing
January 2019
11 Reads

Role of Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein K (gK) Pathogenic CD8 T Cells in Exacerbation of Eye Disease.

Front Immunol 2018 7;9:2895. Epub 2018 Dec 7.

Department of Surgery, Center for Neurobiology and Vaccine Development, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

HSV-1-induced corneal scarring (CS), also broadly referred to as Herpes Stromal Keratitis (HSK), is the leading cause of infectious blindness in developed countries. It is well-established that HSK is in fact an immunopathological disease. The contribution of the potentially harmful T cell effectors that lead to CS remains an area of intense study. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292954PMC
December 2018

Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors.

PLoS One 2018 28;13(11):e0208163. Epub 2018 Nov 28.

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

To investigate the clinical characteristics, treatment, risk factors of occurrence and graft transparency of corneal epithelial defects after penetrating keratoplasty in patients with infectious keratitis. 594 patients (594 eyes) with infectious keratitis treated by penetrating keratoplasty at Shandong Eye Institute were reviewed retrospectively between January 2008 and January 2018. We investigated the demographic data, diameter and sources of graft, onset time, location, scope, time of healing and treatment of epithelial defects, as well as other postoperative complications and graft clarity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208163PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261636PMC
November 2018
7 Reads

Clinical management of herpes simplex virus infections: past, present, and future.

F1000Res 2018 31;7. Epub 2018 Oct 31.

Department of Pathobiology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.

Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Read More

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https://f1000research.com/articles/7-1726/v1
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http://dx.doi.org/10.12688/f1000research.16157.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213787PMC
October 2018
8 Reads

Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty.

J Ophthalmol 2018 22;2018:4351460. Epub 2018 Oct 22.

Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Jinan, China.

Purpose: To observe clinical characteristics and treatment outcomes of new onset herpes simplex keratitis (HSK) after keratoplasty.

Methods: Among 1,443 patients (1,443 eyes) who underwent keratoplasty (excluding cases of primary HSK) in Shandong Eye Hospital, 17 patients suffered postoperative HSK. The clinical manifestations, treatment regimens, and prognoses of the patients were evaluated. Read More

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https://www.hindawi.com/journals/joph/2018/4351460/
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http://dx.doi.org/10.1155/2018/4351460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217905PMC
October 2018
64 Reads

Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea.

Cell Mol Life Sci 2019 Feb 16;76(3):405-419. Epub 2018 Oct 16.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor St, Chicago, IL, 60612, USA.

Herpes simplex virus type-1 (HSV-1) is a ubiquitous pathogen that infects a large majority of the human population worldwide. It is also a leading cause of infection-related blindness in the developed world. HSV-1 infection of the cornea begins with viral entry into resident cells via a multistep process that involves interaction of viral glycoproteins and host cell surface receptors. Read More

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http://link.springer.com/10.1007/s00018-018-2938-1
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http://dx.doi.org/10.1007/s00018-018-2938-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349487PMC
February 2019
25 Reads
5.810 Impact Factor

Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation.

Ocul Surf 2019 Jan 11;17(1):40-49. Epub 2018 Oct 11.

Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA.

Herpes simplex virus type 1 (HSV) keratitis is a leading cause of infectious blindness. Clinical disease occurs variably throughout the cornea from epithelium to endothelium and recurrent HSV stromal keratitis is associated with corneal scarring and neovascularization. HSV keratitis can be associated with ocular pain and subsequent neutrophic keratopathy. Read More

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http://dx.doi.org/10.1016/j.jtos.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340725PMC
January 2019
4 Reads

Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence.

Korean J Ophthalmol 2018 Oct;32(5):353-360

Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea.

Purpose: To describe the clinical manifestations of herpes simplex keratitis (HSK) in a tertiary referral center in South Korea and to determine whether ascorbic acid treatment prevents recurrence of herpetic epithelial keratitis.

Methods: This retrospective cohort study included all consecutive patients with herpetic keratitis referred to our center from January 2010 to January 2015. Clinical features, ocular complications, and recurrences were recorded. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3341/kjo.2017.01
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http://dx.doi.org/10.3341/kjo.2017.0131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182212PMC
October 2018
4 Reads

Topical cyclosporine-A versus prednisolone for herpetic stromal keratitis: a randomized controlled trial.

Acta Ophthalmol 2018 Oct 3. Epub 2018 Oct 3.

Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose: To compare topical cyclosporine-A 2% eye drop (Cs-A) with prednisolone acetate 1% eye drop for treatment of herpetic stromal keratitis (HSK).

Methods: In this randomized clinical trial, 38 eyes of 33 patients with HSK were randomly assigned to receive either 2% Cs-A or 1% prednisolone acetate eye drops. All subjects received oral acyclovir 400 mg twice a day. Read More

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http://doi.wiley.com/10.1111/aos.13913
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http://dx.doi.org/10.1111/aos.13913DOI Listing
October 2018
4 Reads

Herpes simplex virus keratitis mimicking Acanthamoeba keratitis: a clinicopathological correlation.

BMJ Case Rep 2018 Sep 19;2018. Epub 2018 Sep 19.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York City, New York, USA.

A 36-year-old male, soft contact lens wearer was referred by his primary ophthalmologist for corneal ulcer of the right eye (OD), which was persistent despite topical fluoroquinolone therapy for 1 month. A ring-shaped infiltrate typically seen in Acanthamoeba infection was noted, and topical therapy with chlorhexidine and polyhexamethylene biguanide was initiated. However, the patient's condition deteriorated over the next several weeks; thus, diagnostic and therapeutic penetrating keratoplasty was performed. Read More

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http://dx.doi.org/10.1136/bcr-2018-226100DOI Listing
September 2018
4 Reads

A Review of the Cytokine IL-17 in Ocular Surface and Corneal Disease.

Curr Eye Res 2018 Sep 19:1-10. Epub 2018 Sep 19.

d Institute of Ophthalmology , University College London , London , England.

Aim: To investigate the role of interleukin-17 in ocular surface and corneal disease. Ocular surface and corneal disease is a leading cause of blindness and is an ongoing challenge for the public health sector to implement effective therapies. The majority of cells in corneal lesions are derived primarily from neutrophils that induce inflammatory events that lead to tissue damage. Read More

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http://dx.doi.org/10.1080/02713683.2018.1519834DOI Listing
September 2018
3 Reads

Current Practice Patterns and Opinions on the Management of Recent-Onset or Chronic Herpes Zoster Ophthalmicus of Zoster Eye Disease Study Investigators.

Cornea 2019 Jan;38(1):13-17

Department of Ophthalmology, New York University School of Medicine, New York, NY.

Purpose: To determine practices and opinions among study investigators in the Zoster Eye Disease Study (ZEDS) regarding suppressive valacyclovir treatment for recent-onset and chronic herpes zoster ophthalmicus (HZO).

Methods: An Internet-based survey was distributed to 170 ZEDS study investigators with questions regarding treatment practices for stromal keratitis in HZO and opinions regarding the efficacy of prolonged antiviral prophylaxis.

Results: The response rate was 72. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279559PMC
January 2019
23 Reads

Rituximab and bilateral HSV epithelial keratitis in a patient with mucous membrane pemphigoid.

J Ophthalmic Inflamm Infect 2018 Aug 23;8(1):12. Epub 2018 Aug 23.

Department of Dermatology, University Hospital of Bern, Bern, Switzerland.

Background: B cell depleting therapy is widely used for lymphoproliferative diseases and immune-mediated disorders, including mucous membrane pemphigoid. The latter is an autoimmune blistering disease affecting predominantly the mucosae potentially associated with devastating complications.

Methods: A 71-year-old patient with severe mucous membrane pemphigoid involving ocular, oral pharyngeal and laryngeal involvement is described. Read More

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http://dx.doi.org/10.1186/s12348-018-0153-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107448PMC
August 2018
1 Read

Effect of storage time and temperature on the detection of Pseudomonas aeruginosa, Acanthamoeba and Herpes Simplex Virus from corneal impression membranes.

J Med Microbiol 2018 Sep 27;67(9):1321-1325. Epub 2018 Jul 27.

1​St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.

The effect of storage time and temperature on the recovery of pathogen DNA from polytetrafluorethylene (PTFE) was investigated. PTFE impression membranes were inoculated with Pseudomonas aeruginosa, Herpes Simplex Virus-1 (HSV-1) or Acanthamoeba and stored at -70 °C, -20 °C, +4 °C or +35 °C. PCR was performed on days 0, 1, 2, 3, 7 and months 1, 3 and 10 post-inoculation. Read More

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http://dx.doi.org/10.1099/jmm.0.000812DOI Listing
September 2018
3 Reads

Transcriptional Profile and Integrative Analyses of Long Noncoding RNAs in Primary Human Corneal Epithelial Cells in Response to HSV-1 Infection.

Curr Eye Res 2018 Dec 17;43(12):1422-1431. Epub 2018 Aug 17.

c Institute of Ophthalmology, School of Medicine , Jinan University , Guangzhou , China.

Purpose: Long noncoding RNAs (lncRNAs) have been demonstrated to have important regulatory functions in diverse cellular processes; however, the role of lncRNAs in the pathogenesis of herpes simplex keratitis (HSK) remains poorly understood.

Methods: Primary human corneal epithelial cells (HCECs) were infected with herpes simplex virus-1 (HSV-1) and the total RNAs extracted from both the infected group and the mock-infected group subjected to microarray analysis to identify the differential expression of lncRNAs and mRNAs. We also performed bioinformatic analysis including gene ontology (GO) analysis, pathway analysis and co-expression network analysis. Read More

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http://dx.doi.org/10.1080/02713683.2018.1504085DOI Listing
December 2018
15 Reads
1.663 Impact Factor

PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice.

Invest Ophthalmol Vis Sci 2018 Jun;59(7):2923-2931

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.

Purpose: The purpose of this study was to explore the effects of pigment epithelium derived factor (PEDF) and PEDF-derived peptides Mer44 and Mer34 on the severity of herpetic simplex keratitis (HSK) in mice.

Methods: Adult C57BL/6 mice were infected ocularly with the herpes simplex virus type 1 (HSV-1, McKrae strain) and injected subconjunctivally with PEDF, Mer44, or Mer34. Corneal nerve degeneration, neovascularization, sensitivity, neutrophils, macrophages and CD4+ T-cell infiltration, virus contents, and expressions of VEGF, PEDF, and proinflammatory factors were evaluated during acute period. Read More

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http://dx.doi.org/10.1167/iovs.18-23942DOI Listing
June 2018
6 Reads
3.400 Impact Factor

Diagnosing superinfection keratitis with multiplex polymerase chain reaction.

J Infect Chemother 2018 Dec 11;24(12):1004-1008. Epub 2018 Jul 11.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Purpose: To report the potential usefulness of multiplex polymerase chain reaction (mPCR) for diagnosing superinfection keratitis caused by herpes simplex virus-1 (HSV-1), bacteria and fungus.

Methods: Case series. Corneal scrapings were analyzed with mPCR for human herpes virus 1-8, bacterial 16S ribosomal DNA (rDNA) and fungal 28S rDNA. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.06.012DOI Listing
December 2018
20 Reads

Evaluation of the Effectiveness of Cross-Linking Combined With Photorefractive Keratectomy for Treatment of Keratoconus.

Cornea 2018 Sep;37(9):1143-1150

Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Purpose: To evaluate the effectiveness and safety of combined epithelium-off cross-linking (CXL) with photorefractive keratectomy (CXL Plus) for correction of the myopic and astigmatic components of keratoconus.

Methods: Seventy-nine eyes of 46 patients who underwent CXL Plus were enrolled in this retrospective, multicenter, noncomparative clinical study. Uncorrected distance visual acuity, corrected distance visual acuity, refraction, keratometry, and pachymetry measurements were recorded preoperatively and at 3, 6, 12, and 18 months during follow-up. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092093PMC
September 2018
4 Reads
2.360 Impact Factor

Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease.

J Virol 2018 09 16;92(17). Epub 2018 Aug 16.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA

We previously isolated a herpes simplex virus 1 (HSV-1) mutant, KOS-NA, that carries two nonsynonymous mutations in , resulting in L393P and R950H amino acid substitutions in infected cell protein 6 (ICP6). Our published data studying KOS-NA pathogenesis strongly suggest that one of these ICP6 substitutions expressed from KOS-NA, R950H, severely impaired acute viral replication in the eyes and trigeminal ganglia of mice after inoculation onto the cornea and consequently impaired establishment and reactivation from latency. Because of its significant neuroattenuation, we tested KOS-NA as a potential prophylactic vaccine against HSV-1 in a mouse model of corneal infection. Read More

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http://dx.doi.org/10.1128/JVI.01036-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096795PMC
September 2018
11 Reads

Human Asymptomatic Epitope Peptide/CXCL10-Based Prime/Pull Vaccine Induces Herpes Simplex Virus-Specific Gamma Interferon-Positive CD107 CD8 T Cells That Infiltrate the Corneas and Trigeminal Ganglia of Humanized HLA Transgenic Rabbits and Protect against Ocular Herpes Challenge.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California, Irvine, Irvine, California, USA

Herpes simplex virus 1 (HSV-1) is a prevalent human pathogen that infects the cornea, causing potentially blinding herpetic disease. A clinical herpes vaccine is still lacking. In the present study, a novel prime/pull vaccine was tested in a human leukocyte antigen (HLA) transgenic rabbit model of ocular herpes (HLA Tg rabbits). Read More

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http://dx.doi.org/10.1128/JVI.00535-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069188PMC
August 2018
17 Reads

Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA

During herpes simplex virus (HSV) latency, most viral genes are silenced, with the exception of one region of the genome encoding the latency-associated transcript (LAT). This long noncoding RNA was originally described as having a role in enhancing HSV-1 reactivation. However, subsequent evidence showing that the LAT blocked apoptosis and promoted efficient establishment of latency suggested that its effects on reactivation were secondary to establishment. Read More

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http://dx.doi.org/10.1128/JVI.00812-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069208PMC
August 2018
3 Reads
4.439 Impact Factor

Herpetic eye disease study: lessons learned.

Curr Opin Ophthalmol 2018 Jul;29(4):340-346

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Purpose Of Review: Ophthalmic herpes simplex virus (HSV) of the anterior segment is responsible for a range of corneal complications such as scarring, thinning, neovascularization, and severe loss of vision. This review provides current guidelines for treating anterior segment disease related to HSV.

Recent Findings: We first review findings from the Herpetic Eye Disease Study (HEDS) clinical trials, and then review new topical and antiviral therapies developed since the HEDS studies. Read More

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http://Insights.ovid.com/crossref?an=00055735-201807000-0001
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http://dx.doi.org/10.1097/ICU.0000000000000482DOI Listing
July 2018
25 Reads

On the role of retinoic acid in virus induced inflammatory response in cornea.

Microbes Infect 2018 Jun - Jul;20(6):337-345. Epub 2018 May 26.

Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, 37996, USA. Electronic address:

Ocular infection with herpes simplex virus (HSV) can result in a chronic immune inflammatory lesion that is a significant cause of human blindness. A key to controlling stromal keratitis (SK) lesion severity is to identify cellular and molecular events responsible for tissue damage and to counteract them. One potentially useful approach to achieve such therapy is Retinoic Acid (RA). Read More

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http://dx.doi.org/10.1016/j.micinf.2018.04.007DOI Listing
May 2018
1 Read

Herpes zoster ophthalmicus: acute keratitis.

Authors:
Jennifer Y Li

Curr Opin Ophthalmol 2018 Jul;29(4):328-333

University of California, Davis, UC Davis Eye Center Sacramento, California, USA.

Purpose Of Review: Herpes zoster is a common condition, and involvement of the trigeminal nerve results in herpes zoster ophthalmicus (HZO). Acute keratitis is one of the most common of these ocular complications associated with HZO. The findings associated with and the management of acute zoster keratitis will be reviewed. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000491DOI Listing
July 2018
2 Reads

Management of Herpes Simplex Virus Keratitis in the Pediatric Population.

Pediatr Infect Dis J 2018 Sep;37(9):949-951

From the Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD.

Herpes simplex virus (HSV) keratitis is a highly prevalent and visually disabling disease in both the pediatric and adult population. While many studies have investigated the treatment of HSV keratitis in adult patients, few have focused on managing this condition in children. Children are at particularly high risk for visual morbidity due to unique challenges in diagnosis and treatment, and the often more aggressive disease course that results in corneal scarring, and subsequently amblyopia. Read More

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http://dx.doi.org/10.1097/INF.0000000000002114DOI Listing
September 2018
6 Reads

Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis.

Clin Exp Ophthalmol 2018 Dec 30;46(9):1008-1016. Epub 2018 May 30.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

Importance: To standardize initial anti-viral therapy for herpes simplex keratitis (HSK).

Background: To determine prescribing trends for the management of HSK and compare the trends to available clinical trial evidence.

Design: Retrospective review of patients at the Sydney Eye Hospital, Australia. Read More

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http://dx.doi.org/10.1111/ceo.13319DOI Listing
December 2018
3 Reads

Surgical management of herpetic keratitis.

Curr Opin Ophthalmol 2018 Jul;29(4):347-354

Department of Ophthalmology, University of Florida, Gainesville, Florida, USA.

Purpose Of Review: The purpose of this review is to discuss the options for, and recent developments in, the surgical treatment of herpes keratitis. Although the mainstay of treatment of herpetic keratitis is topical or oral antiviral agents, surgical intervention may be necessary for corneal melting or long-term complications such as scarring, lipid keratopathy, necrotizing keratitis, and neurotrophic keratitis.

Recent Findings: There are a number of surgical therapies available for herpes keratitis. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000484DOI Listing
July 2018
3 Reads

Management of herpes simplex virus epithelial keratitis.

Curr Opin Ophthalmol 2018 Jul;29(4):360-364

Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Purpose Of Review: To review recent advancements in the management of herpes simplex virus (HSV) epithelial keratitis.

Recent Findings: Trifluridine eye drop, acyclovir (ACV) ointment, ganciclovir gel, and oral ACV are still the main therapeutic agents. Cryopreserved amniotic membrane has been recently used as an adjuvant treatment. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000483DOI Listing
July 2018
5 Reads

Bilateral herpes simplex keratitis reactivation after lacrimal gland botulinum toxin injection.

Indian J Ophthalmol 2018 05;66(5):697-699

Cornea Services, LJ Eye Institute, Ambala, Haryana, India.

Botulinum toxin A (BTA) injections into lacrimal gland are being used for refractory epiphora due to intractable lacrimal disorders with success rates reported from 18% to 86%. Most common side effects are transient ptosis and diplopia. We report a case of a 59-year-old female injected with 2. Read More

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http://dx.doi.org/10.4103/ijo.IJO_904_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939169PMC
May 2018
10 Reads

[Uveitis treated with biotherapy and/or DMARD: Analysis from the French Pharmacovigilance Study Base].

J Fr Ophtalmol 2018 Apr 13;41(4):350-356. Epub 2018 Apr 13.

Service de rhumatologie, hôpital Pasteur 2, CHU de Nice, 30, voie Romaine, CS 51069, 06001 Nice cedex 1, France. Electronic address:

Purpose: To report the characteristics of uveitis cases occurring while on biologic therapy or disease-modifying antirheumatic drugs (DMARDs) reported to the French national pharmacovigilance database.

Methods: All the uveitis cases occurring in patients with chronic rheumatologic diseases, chronic inflammatory intestinal diseases or connective tissue diseases, while treated with DMARDs and/or biologic therapies between 2000 and 2015 and reported to the French National Pharmacovigilance Database were collected.

Results: During the study period, 32 cases of uveitis were reported (15 men, 17 women). Read More

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http://dx.doi.org/10.1016/j.jfo.2017.11.012DOI Listing

Epithelial Keratitis After Cataract Surgery.

Cornea 2018 Jun;37(6):755-759

Department of Ophthalmology, University of Utah College of Medicine, Salt Lake City, UT.

Purpose: To evaluate the incidence, related perioperative factors, clinical characteristics, and possible etiologies of epithelial keratitis after cataract surgery.

Methods: A retrospective chart review of 666 eyes in 666 patients who underwent cataract surgery was performed to evaluate the incidence of epithelial keratitis and related factors in the postoperative period.

Results: Postoperative epithelial keratitis developed in 15 eyes. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376864PMC
June 2018
17 Reads

Improvement of chronic corneal opacity in ocular surface disease with prosthetic replacement of the ocular surface ecosystem (PROSE) treatment.

Am J Ophthalmol Case Rep 2018 Jun 15;10:108-113. Epub 2018 Feb 15.

BostonSight, 464 Hillside Ave, Suite 205, Needham, MA, 02494, United States.

Purpose: To demonstrate clearing of chronic corneal opacities and improvement of visual acuity with the use of BostonSight prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in ocular surface disease.

Observations: We undertook retrospective analysis of the medical records of a series of patients who underwent PROSE treatment from August 2006 to December 2014. Patients were referred for ocular surface disease of various etiologies. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852325PMC
June 2018
1 Read

Role of Dendritic Cells and Inflammatory Cells in Herpetic Endotheliitis: Analysis Using In Vivo Confocal Microscopy.

Cornea 2018 Jun;37(6):748-754

Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Jinan, China.

Purpose: To observe the pathological changes in dendritic cells (DCs) and inflammatory cells in the corneal epithelium and endothelium using in vivo confocal microscopy during the management of herpetic endotheliitis.

Methods: A total of 110 eyes with herpetic endotheliitis were included. All patients were treated with antiviral agents combined with glucocorticoids. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001571DOI Listing
June 2018
4 Reads

A 20-year experience of ocular herpes virus detection using immunofluorescence and polymerase chain reaction.

Clin Exp Optom 2018 Sep 6;101(5):648-651. Epub 2018 Mar 6.

Department of Ocular Microbiology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Background: To detect the presence of herpes virus in corneal scrapings/corneal grafts of suspected herpetic keratitis patients attending the outpatient department/casualty of the Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi for the past 20 years with immunofluorescence assay and to analyse the efficacy of polymerase chain reaction over immunofluorescence for routine laboratory diagnosis in some of the specimens.

Methods: Corneal scrapings and corneal grafts were collected by the ophthalmologists from 1,926 suspected herpetic keratitis patients between 1996 and 2015, among whom 1,863 patients were processed with immunofluorescence assay and 302 patients were processed with polymerase chain reaction assay for the detection of herpes virus. Of the 302 patients, clinical specimens from 239 patients were analysed by both polymerase chain reaction and immunofluorescence assay. Read More

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http://dx.doi.org/10.1111/cxo.12669DOI Listing
September 2018
11 Reads

Corneal perforation after noncontact tonometry in patients with active recurrent herpes simplex keratitis: case report.

Int Ophthalmol 2018 Feb 7. Epub 2018 Feb 7.

Department of Ophthalmology, Chiang Mai University, Chiang Mai, 50200, Thailand.

Purpose: To report iatrogenic complications and to review the potential complications caused by noncontact tonometry (NCT) in related literature.

Methods: This case report describes two cases of active recurrent herpes simplex keratitis (HSK) on top of a thin corneal scar. The cornea was perforated by the air pulse from the NCT, resulting in an air bubble in the anterior chamber. Read More

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http://dx.doi.org/10.1007/s10792-018-0854-xDOI Listing
February 2018
2 Reads

Reactivation of herpes simplex viral keratitis following the botulinum toxin injection.

Indian J Ophthalmol 2018 02;66(2):306-308

Jhaveri Microbiology Center, L V Prasad Eye Institute, Hyderabad, India.

We describe a case of 55-year-old male farmer presented with recurrent corneal abrasions with a spastic entropion in the left eye. Superior cornea showed typical nummular opacities suggestive resolved herpetic eye diseases. On further enquiry, he had similar episodes in the past. Read More

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http://dx.doi.org/10.4103/ijo.IJO_714_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819125PMC
February 2018
10 Reads

A comparative study of risk factors for corneal infection in diabetic and non-diabetic patients.

Int J Ophthalmol 2018 18;11(1):43-47. Epub 2018 Jan 18.

Qingdao Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, China.

Aim: To compare the clinical characteristics of infectious keratopathy in type 2 diabetes mellitus (T2DM) and non-diabetes mellitus (NDM) and to investigate risk factors for infectious keratopathy in T2DM patients.

Methods: Totally 230 patients with T2DM and 168 with NDM diagnosed as infectious keratopathy were hospitalized at Qingdao Eye Hospital from 2001 to 2015. Data including sex, age, occupation, season, smoking and alcohol consumption habits, duration between onset and treatments, duration of hospitalization were collected. Read More

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http://dx.doi.org/10.18240/ijo.2018.01.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767656PMC
January 2018
8 Reads

Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis.

Immunotherapy 2018 03;10(3):189-200

Department of Ophthalmology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing University, Nanjing, Jiangsu, China.

Aim: The aim of this study is to investigate the effects of constructed dendritic cell (DC)-based DNA vaccine (pRSC-NLDC145.gD-IL21) carried by chitosan nanoparticle in preventing primary or recurrent herpes simplex virus keratitis (HSK) in mice.

Methods: The expression of constructed plasmid 'pRSC-NLDC145. Read More

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http://dx.doi.org/10.2217/imt-2017-0060DOI Listing
March 2018
4 Reads

Richner-Hanhart syndrome (tyrosinemia type II).

Cutis 2017 12;100(6):E20-E22

Service de Dermatologie, CHU, 3 Blvd Alexandre Fleming, 25030 Besançon, France.

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December 2017
4 Reads

Hexokinase II may be dispensable for CD4 T cell responses against a virus infection.

PLoS One 2018 19;13(1):e0191533. Epub 2018 Jan 19.

Department of Genome Science and Technology, University of Tennessee, Knoxville, Tennessee, United States of America.

Activation of CD4 T cells leads to their metabolic reprogramming which includes enhanced glycolysis, catalyzed through hexokinase enzymes. Studies in some systems indicate that the HK2 isoform is the most up regulated isoform in activated T cells and in this report the relevance of this finding is evaluated in an infectious disease model. Genetic ablation of HK2 was achieved in only T cells and the outcome was evaluated by measures of T cell function. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191533PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774810PMC
February 2018
1 Read

Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis.

Ocul Immunol Inflamm 2018 18;26(3):333-337. Epub 2018 Jan 18.

d Department of Ophthalmology , University Medical Center , Utrecht , The Netherlands.

Purpose: The aim of this study is to describe the clinical characteristics of molecularly proven Herpes simplex virus (HSV) anterior uveitis.

Methods: The literature on HSV anterior uveitis whereby the diagnosis was confirmed by polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient in aqueous humor was reviewed. Three studies from Europe and one from Japan could be included. Read More

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http://dx.doi.org/10.1080/09273948.2017.1420806DOI Listing
July 2018
2 Reads

Acanthamoeba keratitis in Porto Alegre (southern Brazil): 28 cases and risk factors.

Parasitol Res 2018 Mar 14;117(3):747-750. Epub 2018 Jan 14.

Department of Microbiology, Immunology and Parasitology, Institute of Basic Health Sciences, Department of Parasitology, Universidade Federal do Rio Grande do Sul, Sarmento Leite Street, N 500, Porto Alegre, Rio Grande do Sul, 90050-170, Brazil.

The increasing use of contact lenses worldwide has led to an increase in cases of Acanthamoeba keratitis, which are often associated with inappropriate cleaning of contact lenses and lens cases. This study aimed to retrospectively review 28 cases of Acanthamoeba keratitis in Porto Alegre (southern Brazil) and identify the risk factors and clinical outcomes of affected patients. Most patients had higher education (66. Read More

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http://dx.doi.org/10.1007/s00436-017-5745-yDOI Listing
March 2018
10 Reads

Application of our understanding of pathogenesis of herpetic stromal keratitis for novel therapy.

Microbes Infect 2018 Oct - Nov;20(9-10):526-530. Epub 2018 Jan 9.

Biomedical & Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN, 37996-0845, United States. Electronic address:

HSV-1 ocular infection can cause herpes stromal keratitis (SK), an immunopathological lesion. Frequent recurrences can lead to progressive corneal scaring which can result in vision impairment if left untreated. Currently, the acute and epithelial forms of SK are usually controlled using anti-viral drugs. Read More

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http://dx.doi.org/10.1016/j.micinf.2017.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037561PMC
January 2018
3 Reads

Etiological mechanism of iridocorneal endothelial (ICE) syndrome may involve infection of herpes simplex virus (HSV) and integration of viral genes into human genome.

Med Hypotheses 2018 Jan 26;110:50-52. Epub 2017 Oct 26.

Zhongshan Ophthalmic Center, The State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China. Electronic address:

Iridocorneal (ICE) syndrome is a rare ocular disease characterized by abnormal proliferation of corneal endothelial cells, progressive obstruction of irido-corneal angle and atrophy of iris. ICE syndrome progressed slowly, but can cause serious complications such as secondary glaucoma in late stage. Because the etiology of ICE syndrome is not clear, there is still no effective treatment in clinical practice. Read More

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http://dx.doi.org/10.1016/j.mehy.2017.10.023DOI Listing
January 2018
19 Reads

Corneal nerve regeneration after herpes simplex keratitis: A longitudinal in vivo confocal microscopy study.

Ocul Surf 2018 Apr 3;16(2):218-225. Epub 2018 Jan 3.

Ocular Surface Imaging Center, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA; Center for Translational Ocular Immunology, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA. Electronic address:

Purpose: To evaluate the long-term alterations of corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM).

Design: Prospective, longitudinal, cross sectional.

Methods: This study included 16 patients with a history of HSV keratitis and 15 age-matched normal controls. Read More

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http://dx.doi.org/10.1016/j.jtos.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889330PMC
April 2018
17 Reads

keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications.

Br J Ophthalmol 2018 Oct 3;102(10):1431-1435. Epub 2018 Jan 3.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Background/aims: To determine demographic and clinical features of patients with keratitis (AK) that are independent risk factors both for bad outcomes and for severe inflammatory complications (SIC).

Methods: A retrospective audit of medical records of AK cases at Moorfields Eye Hospital from July 2000 to April 2012, including 12 earlier surgical cases. Cases with a bad outcome were defined as those having one or more of the following: corneal perforation, keratoplasty, other surgery (except biopsy), duration of antiamoebic therapy (AAT) ≥10. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2017-310806DOI Listing
October 2018
3 Reads

Are miRNAs critical determinants in herpes simplex virus pathogenesis?

Microbes Infect 2018 Oct - Nov;20(9-10):461-465. Epub 2017 Dec 26.

Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA. Electronic address:

miRNAs are small noncoding RNA that play a crucial role in gene regulation by inhibiting translation or promoting mRNA degradation. Viruses themselves express miRNAs that can target either the host or viral mRNA transcriptome. Moreover, viral infection of cells causes a drastic change in host miRNAs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12864579173022
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http://dx.doi.org/10.1016/j.micinf.2017.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019638PMC
December 2017
12 Reads