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Vestn Oftalmol 2021 ;137(3):21-25

Children's Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Kazan, Russia.

Currently, the number of contact lens users in the world is approximately 10% of the total population of developed countries. Despite the undeniable advantages of contact lenses over eyeglasses, complications are an unpleasant aspect of their use. An analysis of the literature showed that purulent-inflammatory complications have not been fully described. Read More

Mol Biotechnol 2021 Jun 22. Epub 2021 Jun 22.

School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.

Riboflavin is widely regarded as an essential nutrient that is involved in biological oxidation in vivo. In addition to preventing and treating acyl-CoA dehydrogenase deficiency in patients with keratitis, stomatitis, and glossitis, riboflavin is also closely related to the treatment of radiation mucositis and cardiovascular disease. Chemical synthesis has been the dominant method for producing riboflavin for approximately 50 years. Read More

Sci Rep 2021 Jun 21;11(1):13007. Epub 2021 Jun 21.

Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.

Infectious keratitis (IK) is the 5th leading cause of blindness globally. Broad-spectrum topical antimicrobial treatment is the current mainstay of treatment for IK, though adjuvant treatment or surgeries are often required in refractory cases of IK. This systematic review aimed to examine the effectiveness and safety of adjuvant amniotic membrane transplantation (AMT) for treating IK. Read More

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

University Health Systems of Eastern Carolina, Greenville, North Carolina, USA.

Two months following penetrating keratoplasty for keratitis, a 76-year-old man was referred due to inability to wean high-dose topical steroids. Despite a very healthy graft and minimal pain, a scleral abscess involving three clock hours of the superior conjunctiva was present. The patient underwent conjunctival and scleral excision of the area of apparent infection with adjuvant mitomycin C and double freeze-thaw cryotherapy treatment followed by amniotic membrane graft. Read More

J Ophthalmol 2021 8;2021:5514055. Epub 2021 Jun 8.

Royal Victoria Eye and Ear, Dublin, Ireland.

Objectives: To compare presentation of infectious keratitis during COVID-19 lockdown with previous years, assess relative severity, and compare outcomes between COVID-19 and pre-COVID-19 era groups.

Methods: Acute presentations of infectious keratitis during a strict government-mandated COVID-19 lockdown period were analysed retrospectively (March-May 2020). Data were compared with the same periods in 2018-2019. Read More

Glycoconj J 2021 Jun 19. Epub 2021 Jun 19.

Department of Studies in Biochemistry, Karnatak University, Dharwad, 580003, India.

Physiological role of a core fucose specific lectin from Cephalosporium curvulum isolated from mycotic keratitis patient in mediating pathogenesis was reported earlier. CSL has opposite effects on HCECs, at the initiation of infection when lectin concentration is low, CSL induces proinflammatory response and at higher concentration it inhibits growth as the infection progresses. Here we delineate detailed mechanism of opposing effects of CSL by confirming the binding of CSL and anti TLR 2 and 4 antibodies to TLRs 2 and 4 purified from HCECs using Galectin-3 Sepharose 4B column. Read More

Indian J Ophthalmol 2021 Jul;69(7):1658-1669

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Laser-assisted in situ keratomileusis (LASIK) is one of the most commonly performed kerato-refractive surgery globally. Since its introduction in 1990, there has been a constant evolution in its technology to improve the visual outcome. The safety, efficacy, and predictability of LASIK are well known, but complications with this procedure, although rare, are not unknown. Read More

Nat Commun 2021 06 18;12(1):3738. Epub 2021 Jun 18.

Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.

Keratitis is the main cause of corneal blindness worldwide. Most vision loss caused by keratitis can be avoidable via early detection and treatment. The diagnosis of keratitis often requires skilled ophthalmologists. Read More

Med Mycol Case Rep 2021 Sep 25;33:1-4. Epub 2021 May 25.

Institute of Ophthalmology, University of Modena and Reggio Emilia, Modena, Italy.

We report an atypical presentation of keratitis which unusually presented in a 85-year-old patient with a corneal ulcer with an anterior segment inflammation and . Despite negative culture and unspecific results from panfungal PCR-based sequencing, the patient was treated for a presumed fungal infection. Following clinical deterioration an emergency surgical intervention with apposition of a corneal patch was performed. Read More

Sci Transl Med 2021 Jun;13(598)

Innovative Molecules GmbH, Leopoldshöher Str. 7, 32107 Bad-Salzuflen, Germany.

More than 50% of the world population is chronically infected with herpesviruses. Herpes simplex virus (HSV) infections are the cause of herpes labialis (cold sores), genital herpes, and sight-impairing keratitis. Less frequently, life-threatening disseminated disease (encephalitis and generalized viremia) can also occur, mainly in immunocompromised patients and newborns. Read More

Clin Exp Optom 2021 Jun 16:1-7. Epub 2021 Jun 16.

Department of Ophthalmology, Başkent University Faculty of Medicine, Ankara, Turkey.

: Effective treatment of corneal epithelial defects is crucial to prevent secondary infectious keratitis and visual impairment due to loss of corneal transparency. Therefore, it is important to determine the effect of different topical agents on corneal wound healing response.: The aim was to compare the effects of three different eye drops on corneal epithelial wound healing in an experimental model. Read More

Clin Exp Optom 2021 Jun 16:1-3. Epub 2021 Jun 16.

Department of Confocal Scan, Central Eye Bank of Iran, Tehran, Iran.

J Clin Microbiol 2021 Jun 16:JCM0022821. Epub 2021 Jun 16.

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA.

Infections caused by , spp., and result in a variety of clinical manifestations in humans. These amoebae are found in water and soil worldwide. Read More

Am J Case Rep 2021 Jun 16;22:e930467. Epub 2021 Jun 16.

Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

BACKGROUND Herpes simplex virus (HSV) stromal keratitis with ulceration is one of the most serious forms of herpes corneal infection and is one of the most difficult conditions in terms of clinical management. We assessed the efficacy of intravenous acyclovir in the treatment of this condition. CASE REPORT Two cases of HSV stromal keratitis with ulceration were reported in terms of clinical presentation, investigation, treatment, and outcome. Read More

J Int Med Res 2021 Jun;49(6):3000605211020246

Department of Ophthalmology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.

The coexistence of Mooren's ulcer and a pterygium is an extremely rare ocular condition that has been infrequently reported in the literature to date. We herein present the first case of treatment of Mooren's ulcer coexisting with a pterygium using a lenticule obtained by myopic small-incision lenticule extraction (SMILE). A 61-year-old woman presented with a 3-month history of recurrent ocular pain and red eye caused by Mooren's ulcer coexisting with a pterygium. Read More

Sci Rep 2021 Jun 14;11(1):12502. Epub 2021 Jun 14.

Department of Ophthalmology, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan.

Spectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement. We detect subclinical limbal pathologies based on five parameters, including (1) decreased epithelial thickness, (2) loss of the sharp stromal tip, (3) loss of the smooth epithelial-stromal interface, (4) dilated stromal vessels, and (5) decreased POV density. Read More

Acta Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, Homburg/Saar, Germany.

Purpose: To determine herpes simplex virus (HSV) DNA prevalence and mean cycle threshold of polymerase chain reaction (PCR) in corneal tissue of patients with penetrating keratoplasty (PKP), with (HSK+) and without (HSK-) previous clinical herpetic keratitis history.

Methods: Retrospective review of recipient corneal buttons which were explanted through PKP between March 2010 and September 2018 at the Department of Ophthalmology, Saarland University Medical Center in Homburg/Saar, Germany. Corneal tissue samples were analysed by real-time PCR for the presence of HSV DNA. Read More

GMS Ophthalmol Cases 2021 17;11:Doc09. Epub 2021 May 17.

Department of Microbiology, J. N. Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Microbial keratitis is an important cause of ocular morbidity, with emerging organisms and drug resistance posing a real threat to vision of patients. A 30-year-old female presented with infective keratitis in the left eye. She had been using rose nectar as home remedy for her ailment. Read More

Eur J Ophthalmol 2021 Jun 12:11206721211024827. Epub 2021 Jun 12.

Department of Ophthalmology, University of Rome Campus BioMedico, Rome, Italy.

The red eye is one of the most common cause encountered in ophthalmic practice but a red eye is not always related to eye diseases, instead, it may be a clinical sign of several systemic diseases which may the alarmin signal of sight-threatening or life-threatening condition. Frequently, GPs, pediatricians, immunologists, and rheumatologists are the first landing of patients with a "red eye." This paper is addressed to non-ophthalmic specialists who may be faced with patients having a red eye. Read More

Am J Ophthalmol 2021 Jun 9. Epub 2021 Jun 9.

University of Ferrara, Department of Translational Medicine, Ferrara, Italy; Ospedali Privati Forlì "Villa Igea", Department of Ophthalmology, Forlì, Italy; Istituto Internazionale per la Ricerca e Formazione in Oftalmologia (IRFO), Forlì, Italy.

Purpose: To examine the ultrastructure of the natural plane of separation in grafted corneas and evaluate the outcomes of stromal peeling.

Design: Interventional case series METHODS: In this multicenter study, stromal peeling was attempted in 96 consecutive eyes with unsatisfactory vision following penetrating keratoplasty (PK) for keratoconus(n=79), herpetic keratitis(n=11) and granular dystrophy(n=6). Stromal exchange was performed by: 1) 9mm partial-thickness trephination; 2) creation of a corneal flap across the PK wound; 3) opening of the stromal component of the PK wound until a smooth, translucent natural plane was identified; 4) severing the attachment of the PK scar; 5) stromal peeling along the identified plane; 6) suturing of donor lamella. Read More

Clin Exp Ophthalmol 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, University of Auckland, Auckland, New Zealand.

Background: Few studies have evaluated corneal crosslinking in a prospective, randomised fashion. This study aimed to determine the efficacy and safety of corneal crosslinking to reduce the progression of keratoconus.

Methods: Prospective, unmasked, randomised, contralateral eye controlled trial at a tertiary eye centre. Read More

Orphanet J Rare Dis 2021 Jun 11;16(1):270. Epub 2021 Jun 11.

Moorfields Eye Hospital, 51 North Block, 5 Chicheley Street, London, SE1 7PJ, UK.

Purpose: To evaluate the safety and preliminary efficacy of topical rVA576, a dual inhibitor of complement component 5 (C5) and leukotriene B4 (LTB4), in patients with recalcitrant atopic keratoconjunctivitis (AKC) in the open label phase 1 TRACKER clinical trial.

Methods: Three patients diagnosed with moderate or severe AKC who had been on maximal topical treatment (antihistamines and ciclosporin) for at least three months prior to entry, and showed persistent symptoms and signs of inflammation, were recruited into the trial. Patients received rVA576 eye drops twice a day for 8 weeks. Read More

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Cornea and Refractive Surgery, Aravind Eye Care System, Madurai, India; Department of Cataract, S.V. Aravind Eye Hospital, Aravind Eye Care System, Tirupati, India.

Purpose: The aim of this study was to study the clinical and economic impact of a teleophthalmology-based vision center (VC) in the management of corneal diseases in rural south India.

Methods: Data of patients with corneal disorders who visited the VC in the year 2019 were analyzed for the total number of outpatient visits, the proportion of corneal cases that were treated at the VC, those referred to the base hospital (BH), and the costs of treatment.

Results: In 2019, 1131 (10%) of 10,850 patients who visited the VC were diagnosed with corneal disorders. Read More

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL.

Abstract: The presence of Descemet membrane scrolls is an uncommon finding reported in syphilitic interstitial keratitis. We herein describe a novel surgical strategy for this entity; this report demonstrates that Descemet membrane endothelial keratoplasty surgery can be performed with excellent visual outcomes in the event of corneal edema as a late sequela of syphilitic keratitis. Read More

J Photochem Photobiol B 2021 Jun 8;221:112239. Epub 2021 Jun 8.

Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8551, Japan. Electronic address:

TONS504 (C51H58O5I2) is a chlorin derivative that exhibits a photodynamic antimicrobial effect (PAE) on various infectious keratitis pathogens. However, the molecular characteristics of TONS504 are not well understood. This study aimed to investigate the molecular characteristics of TONS504 by comparing its singlet oxygen (O) quantum yields and PAE with those of methylene blue (MB). Read More

J Formos Med Assoc 2021 Jun 7. Epub 2021 Jun 7.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Department of Ophthalmology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan. Electronic address:

Background/purpose: To investigate the clinical characteristics of intraocular lymphoma and to evaluate two protocols of intravitreal methotrexate injection.

Methods: A retrospective chart review was conducted of newly-diagnosed intraocular lymphoma patients between January 2013 and January 2018 at National Taiwan University Hospital. Patients were divided into two groups. Read More

Retina 2021 Jun 8. Epub 2021 Jun 8.

Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California Ophthalmology Department, Paris University, Cochin Hospital, AP-HP, F-75014, Paris, France Universite[Combining Acute Accent] de Paris, Ophthalmology Department, AP-HP, Ho[Combining Circumflex Accent]pital Lariboisière, F-75010, Paris Department of Medicine Statistics Core, University of California, Los Angeles, California, USA.

Purpose: To identify the incidence of, risk factors for, and outcomes of posterior segment complications (PSC) after Boston type 1 keratoprosthesis (KPro) implantation.

Methods: Retrospective, consecutive case series of KPro procedures at the Stein Eye Institute. Data regarding ocular history, intraoperative details, postoperative management, and outcomes were collected. Read More

Transl Vis Sci Technol 2021 Jun;10(7):10

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China.

Purpose: To investigate the relationship between Acanthamoeba cysts and inflammatory cells in Acanthamoeba keratitis (AK) by in vivo confocal microscopy (IVCM).

Methods: A case-control study included 30 patients with AK and 20 normal controls. The severity of the AK was divided into mild, moderate, and severe. Read More

Am J Ophthalmol 2021 Jun 6. Epub 2021 Jun 6.

Consultant, Cornea and Anterior Segment Services. Electronic address:

Am J Ophthalmol 2021 Jun 5. Epub 2021 Jun 5.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.

Purpose: To evaluate the long-term outcomes, anatomical retention and complications of Boston type I keratoprosthesis (KPro).

Design: Retrospective, interventional case series.

Methods: A retrospective chart review of implantations performed January 2008-December 2017 was conducted. Read More