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Antimicrob Agents Chemother 2019 Feb 4. Epub 2019 Feb 4.

Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China.

Bacterial keratitis is an aggressive infectious corneal disease. With the continuing rise in antibiotic resistance and a decline in the discovery of new antibiotics, new antimicrobial drugs are now required. In the present study, we determined the antibacterial activity of diacerein, an anti-inflammatory drug, against 76 Gram-positive cocci isolated from bacterial keratitis patients in vitro and anti- activity in mouse bacterial keratitis model in vivo. Read More

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland

Background/aims: To describe the risk factors, clinical features, bacterial subspecies characteristics and treatment outcomes of Moraxella keratitis in a single centre.

Methods: A retrospective review of all patients diagnosed with Moraxella keratitis between November 2012 and December 2017 at the Royal Victoria Eye and Ear Hospital, Dublin, Ireland was performed. Matrix-assisted laser desorption ionisation time-of-flight (MALDI-TOF) mass spectrometry was used to identify subspecies. Read More

PLoS One 2019 30;14(1):e0211757. Epub 2019 Jan 30.

[This corrects the article DOI: 10.1371/journal.pone. Read More

J Leukoc Biol 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Pseudomonas aeruginosa-induced corneal keratitis is a sight-threatening disease. The rise of antibiotic resistance among P. aeruginosa keratitis isolates makes treatment of this disease challenging, emphasizing the need for alternative therapeutic modalities. Read More

Klin Monbl Augenheilkd 2019 Jan 7. Epub 2019 Jan 7.

Universitätsklinik für Augenheilkunde, Inselspital, Bern, Schweiz.

Background: Infectious keratitis is a serious corneal disease and may lead to permanent visual deterioration if not treated rapidly and effectively. In order to determine possible changes in the spectrum of pathogens over time, we evaluated the pathogenic organisms of keratitis at a university hospital in Switzerland, comparing two time periods within a decade.

Methods: In this retrospective study, 417 patients with the clinical diagnosis of bacterial or fungal keratitis in 2006/07 and 2015/16 were enrolled. Read More

Br J Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

School of Optometry and Vision Science, University of New South Wales, Kensington, Queensland, Australia.

Aims: To estimate the incidence of culture-positive microbial keratitis in Queensland and analyse trends in the organisms and their sensitivities cultured from corneal scrapes, especially low-incidence organisms.

Methods: Retrospective multicentre case series of all positive corneal scrapes in Queensland, Australia between 2005 and 2015. Pathology organisations in Queensland were identified by online and local directory search and agreed to participate. Read More

Surv Ophthalmol 2018 Dec 24. Epub 2018 Dec 24.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA; Infectious Disease Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Microbial keratitis (MK) is a potentially blinding condition which must be treated emergently to preserve vision. Although long recognized as a significant cause of corneal blindness, our understanding of its true global scale, associated burden of disease, and etiological patterns remains somewhat limited. Current epidemiological data suggests that MK may be epidemic in parts of the world--particularly within South, South-East and East Asia--and may exceed two million cases per year world-wide. Read More

Indian J Ophthalmol 2019 Jan;67(1):49-53

Jhaveri Microbiology Centre, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To report the distribution and trends of types of organisms and antibiotic susceptibility of the bacterial isolates obtained from patients with microbial keratitis.

Methods: Microbiology records of culture-positive microbial keratitis that underwent a diagnostic corneal scraping and cultures were reviewed. Fungal, bacterial, and parasitic culture results and antibiotic susceptibility profile of bacteria were analyzed and comparisons were made between two halves of the study period (2007-2010 vs. Read More

Clin Ophthalmol 2018 10;12:2567-2573. Epub 2018 Dec 10.

Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, Saitama, Japan,

Purpose: To determine risk factors and clinical signs for severe keratitis (AK) by comparing severe cases with mild cases with good prognosis.

Patients And Methods: We reviewed medical records of ten cases of AK (five males and five females) referred to our hospital and classified cases into two groups. One eye that required therapeutic keratoplasty and three eyes with a poor visual acuity (<0. Read More

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5993-6002

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, United States.

Purpose: Pseudomonas aeruginosa is the leading cause of contact lens-associated bacterial keratitis. Secreted bacterial proteases have a key role in keratitis, including the P. aeruginosa small protease (PASP), a proven corneal virulence factor. Read More

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8063-8075

Department of Laboratory, Longhua District Central Hospital, Longhua District, Shenzhen, China.

Objective: To investigate the role of NLRP12 in regulating Pseudomonas aeruginosa (P. aeruginosa) keratitis.

Materials And Methods: Real-Time-PCR and Western blot were performed to measure the NLRP12 level in corneas and bone marrow-derived macrophages (BMDMs) of C57BL/6 (B6) mice. Read More

J Biosci 2018 Dec;43(5):835-856

Jhaveri Microbiology Centre, Prof. Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Kallam Anji Reddy campus, Hyderabad 500 034, India.

Dysbiosis, or imbalance in the gut microbiome, has been implicated in auto-immune, inflammatory, neurological diseases as well as in cancers. More recently it has also been shown to be associated with ocular diseases. In the present study, the association of gut microbiome dysbiosis with bacterial Keratitis, an inflammatory eye disease which significantly contributes to corneal blindness, was investigated. Read More

Interdiscip Perspect Infect Dis 2018 13;2018:2525173. Epub 2018 Nov 13.

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. Read More

Prostaglandins Other Lipid Mediat 2019 Feb 4;140:18-25. Epub 2018 Dec 4.

Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, United States. Electronic address:

Vasoactive intestinal peptide (VIP) has been shown to regulate corneal inflammation. Formyl peptide receptor 2 (FPR2) is a transmembrane protein belonging to the GPCR family. Ligands include pro-resolving lipids, lipoxin A4 (LXA4) and resolvin D1 (RvD1). Read More

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):902-910

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.

To study the effects of ultraviolet light combined with riboflavin treatment (corneal collagen-crosslinking, CXL) on infectious control and stromal reconstruction of bacterial keratitis. Experimental Study. A Staphylococcus aureus rabbit keratitis model was established by injecting Staphylococcus aureus broth into the shallow stromal layer of the right eye cornea of New Zealand white rabbits. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Jan 30;257(1):135-141. Epub 2018 Nov 30.

Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.

Purpose: Donor-to-host transmission of infectious agents is a rare but well-recognised complication of corneal transplantation and may carry a grave visual prognosis. In this case series, we describe the clinical features and risk factors of using culture-positive donor corneas for transplantation.

Methods: Retrospective chart review of a series of patients who underwent either penetrating keratoplasty (PK) or Descemet's stripping automated endothelial keratoplasty (DSAEK) with positive microbiology cultivation during routine assessment of donor corneal tissue obtained at the time of surgery. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):213-219

Department of Ophthalmology, Al-Nahdah Hospital, Muscat, Oman.

Objective: The objective of this study is to describe the epidemiology, risk factors, etiology, and outcome of microbial keratitis in a tertiary care center in Muscat, Oman.

Methods: The electronic records of all patients diagnosed with keratitis or corneal ulcer between January 2013 and January 2016 in Al-Nahdha Hospital were retrospectively reviewed. Patients who presented with a corneal ulcer requiring admission and who underwent culture and sensitivity studies were included in the study. Read More

Can J Ophthalmol 2018 Dec 10;53(6):568-573. Epub 2018 Apr 10.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address:

Objective: To study indications for penetrating keratoplasty (PK) at a single site. The trends in the causative organisms for infectious keratitis requiring surgery were also evaluated.

Design: Retrospective observational study. Read More

PLoS One 2018 28;13(11):e0208163. Epub 2018 Nov 28.

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

To investigate the clinical characteristics, treatment, risk factors of occurrence and graft transparency of corneal epithelial defects after penetrating keratoplasty in patients with infectious keratitis. 594 patients (594 eyes) with infectious keratitis treated by penetrating keratoplasty at Shandong Eye Institute were reviewed retrospectively between January 2008 and January 2018. We investigated the demographic data, diameter and sources of graft, onset time, location, scope, time of healing and treatment of epithelial defects, as well as other postoperative complications and graft clarity. Read More

Parasit Vectors 2018 Nov 26;11(1):604. Epub 2018 Nov 26.

Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.

Background: Acanthamoeba spp. can cause serious human infections, including Acanthamoeba keratitis, granulomatous amoebic encephalitis and cutaneous acanthamoebiasis. Cysteine biosynthesis and the L-serine metabolic pathway play important roles in the energy metabolism of Acanthamoeba spp. Read More

Exp Parasitol 2019 Jan 22;196:22-27. Epub 2018 Nov 22.

University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Island, Spain.

Acanthamoeba keratitis (AK) is a sight-threatening corneal infection. The early symptoms include redness, pain, photophobia and intense tearing. Chronic infection usually progresses to stromal inflammation, ring ulcers, corneal opacification and hypopyon. Read More

Ocul Surf 2019 Jan 12;17(1):119-133. Epub 2018 Nov 12.

School of Optometry, University of California, Berkeley, CA, 94720, USA; Graduate Group in Vision Science, University of California, Berkeley, CA, 94720, USA; Graduate Groups in Microbiology, Infectious Diseases & Immunity, University of California, Berkeley, CA, 94720, USA. Electronic address:

Purpose: Contact lens wear carries a risk of complications, including corneal infection. Solving these complications has been hindered by limitations of existing animal models. Here, we report development of a new murine model of contact lens wear. Read More

Cornea 2019 Feb;38(2):146-150

Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To investigate the rate and agents of contamination in bandage soft contact lenses fitted for management of persistent corneal epithelial defects.

Methods: This prospective comparative case series enrolled 57 consecutive eyes fitted with bandage contact lenses for treatment of persistent corneal epithelial defects. The lenses were collected at the time of epithelial closure or when it was necessary to exchange contact lenses and were immediately placed in sterile tubes containing an enriched thioglycolate liquid medium. Read More

Antimicrob Agents Chemother 2019 Jan 21;63(1). Epub 2018 Dec 21.

Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

and are two of the most common causes of bacterial keratitis and corresponding corneal blindness. Accordingly, such infections are predominantly treated with broad-spectrum fluoroquinolones, such as moxifloxacin. Yet, the rising fluoroquinolone resistance has necessitated the development of alternative therapeutic options. Read More

J Ocul Pharmacol Ther 2018 Nov 8. Epub 2018 Nov 8.

1 Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine , Detroit, Michigan.

Purpose: High mobility group box 1 (HMGB1) contributes to adverse disease outcome in Pseudomonas aeruginosa keratitis. This study tests Box A, an HMGB1 antagonist, in a model of the disease.

Methods: C57BL/6 mice (B6) were injected subconjunctivally (1 day before infection) with Box A or phosphate-buffered saline (PBS), infected with P. Read More

Jpn J Infect Dis 2018 Oct 31. Epub 2018 Oct 31.

Section of Microbiology. University Hospital of Guadalajara.

Infectious keratitis is a serious ocular infection that can lead to loss of vision. The aim of the study was to investigate the microbiological characteristics of this infection at the University Hospital of Guadalajara (Spain). We retrospectively reviewed all cases diagnosed between January 2010 and December 2016. Read More

J Vet Med Sci 2018 Dec 29;80(12):1914-1917. Epub 2018 Oct 29.

College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.

Although Moraxella lacunata causes conjunctivitis, keratitis, endocarditis, and otolaryngitis in humans, its infection is rare in animals. We report three cases of asymptomatic pulmonary abscesses caused by M. lacunata in zoo herbivores, including two elks (Cervus canadensis) and a common eland (Taurotragus oryx). Read More

Ophthalmology 2019 Jan 23;126(1):P1-P55. Epub 2018 Oct 23.

Departments of Cornea and External Diseases, Scripps Clinic Torrey Pines, La Jolla, California.

J Colloid Interface Sci 2019 Feb 17;536:112-126. Epub 2018 Oct 17.

Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan, ROC; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan, ROC. Electronic address:

Staphylococcus aureus (S. aureus) is a leading cause of keratitis worldwide and a significant threat to healthy vision. Pathological manifestations of bacterial keratitis (BK) caused by S. Read More

Exp Eye Res 2019 Feb 23;179:47-54. Epub 2018 Oct 23.

The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, USA. Electronic address:

Neutrophil-mediated inflammation plays a critical role in corneal damage following injury or infection. Previous studies demonstrated that membrane-bound FasL (mFasL) induces neutrophil chemokine production. However, the extracellular domain of mFasL is normally cleaved by matrix metalloproteinases to release a soluble form of FasL (sFasL) and sFasL antagonizes mFasL-mediated chemokine production. Read More

Cornea 2019 Feb;38(2):135-140

School of Optometry and Vision Science, University of New South Wales, Australia.

Purpose: To describe the usage patterns of steroids in bacterial keratitis and to analyze the effect of steroids on patients' visual outcomes.

Methods: This was a single-center retrospective review of patients with culture-positive bacterial keratitis treated between 1999 and 2015 at Princess Alexandra Hospital (Brisbane, Australia). Patients with culture-positive bacterial keratitis were identified through the Queensland Pathology Database, and clinical information was gathered through a subsequent medical record review. Read More

J Ophthalmic Inflamm Infect 2018 Oct 24;8(1):19. Epub 2018 Oct 24.

Department of Microbiology and Immunology, Tulane School of Medicine, New Orleans, LA, 70102, USA.

Background: A multipurpose contact lens cleaning solution (MPS) containing novel active ingredients under development was compared to two commercially available MPS solutions for effectiveness against Acanthamoeba isolates.

Methods: The Acanthamoeba isolate A. castellanii was propagated for trophozoite or cyst-containing cultures for the purpose of assessment of effectiveness of each MPS. Read More

Zhonghua Yan Ke Za Zhi 2018 Oct;54(10):767-774

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.

To study the relationship between genetic typing and the antibiotic susceptibility of () isolated from keratitis or conjunctivitis patients. Experimental study. Thirty-four (34) strains of were isolated from 34 cases of keratitis or conjunctivitis. Read More

Cornea 2019 Feb;38(2):246-248

Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA.

Purpose: To report our experience with 2 cases of Capnocytophaga keratitis.

Methods: This is a retrospective study of case reports. We present the clinical presentation, diagnosis, and treatment strategies of 2 patients who presented with Capnocytophaga keratitis. Read More

Exp Eye Res 2019 Feb 19;179:1-7. Epub 2018 Oct 19.

School of Optometry, University of California, Berkeley, CA, USA; Vision Science Program, University of California, Berkeley, CA, USA; Graduate Groups in Microbiology, And Infectious Diseases & Immunity, University of California, Berkeley, CA, USA. Electronic address:

Research with animal models of Pseudomonas aeruginosa keratitis has shown that use of a topical corticosteroid alone against an established infection can significantly increase the number of colonizing bacteria or worsen clinical disease. Moreover, retrospective analysis has suggested that corticosteroid use in humans is associated with an increased risk of keratitis in eyes with pre-existing disease. Thus, while corticosteroids are often used to reduce ocular inflammation in the absence of infection, the risk of opportunistic infection remains a concern. Read More

Cornea 2019 Jan;38(1):84-88

Ophthalmic Plastic and Reconstructive Surgery Service, L. V. Prasad Eye Institute, Bhubaneswar, Odisha, India.

Purpose: Nasolacrimal duct obstruction (NLDO) is believed to be a risk factor for microbial keratitis (MK). The primary objective of this study was to look at microbiological concordance between corneal scraping and lacrimal sac flora in patients with concurrent MK and NLDO. The secondary objective was to compare microbiological isolates from MK and NLDO, MK alone, NLDO alone, and healthy subjects. Read More

J Ocul Pharmacol Ther 2018 Nov 12;34(9):621-627. Epub 2018 Oct 12.

Department of Ophthalmology, School of Medicine, Marmara University , Istanbul, Turkey .

Purpose: The aim of the study was to assess the efficacy of a topical regenerating agent (RGTA) for management of persistent epithelial defects (PEDs) resistant to conventional therapy.

Methods: Twenty-one patients (23 eyes) with PEDs despite the use of conventional therapy for lagophthalmos (n = 4), neurotrophic ulcer (n = 9), chemical burn (n = 3), Stevens-Johnson syndrome (n = 1), atopic keratoconjunctivitis (n = 1), severe dry eye (n = 2), peripheral ulcerative keratitis (n = 1), fungal keratitis (n = 1), and bacterial keratitis (n = 1) were enrolled in the study. Patients were treated with RGTA (Cacicol; Thea, Paris, France) instilled at a dosage of one drop on alternate days. Read More

J Fr Ophtalmol 2018 Nov 3;41(9):823-829. Epub 2018 Oct 3.

Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction: Infectious keratitis is a serious ocular infection that can lead to severe visual impairment and blindness. Bacterial pathogens are responsible for nearly half of infectious keratitis cases. This study was performed to determine the virulence factors, antimicrobial resistance patterns, and biofilm formation ability of Pseudomonas aeruginosa and Staphylococcus spp. Read More

Pract Neurol 2018 Dec 3;18(6):455-464. Epub 2018 Oct 3.

Neurology Department, Wessex Neurosciences Centre, Southampton General Hospital, Tremona Road, Southampton, UK.

Lyme disease (borreliosis) is a tick-borne bacterial infection caused by the spirochaete , transmitted by hard-backed ticks. Actual numbers of cases are increasing and it appears that the distribution across the UK is widening; however, it occurs most frequently in area of woodland, with temperate climate. It typically presents in mid to late summer. Read More

Mater Sci Eng C Mater Biol Appl 2018 Dec 31;93:902-910. Epub 2018 Aug 31.

Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. Electronic address:

The antibacterial effect of the already known water-soluble compound {[Ag(μ-Hmna)(μ-mna)]·[(EtNH)]·(DMSO)·(HO)} (AGMNA) (Hmna = 2‑mercapto‑nicotinic acid) was evaluated by the mean of the Minimum Inhibitory Concentration (MIC), the Minimum Bactericidal Concentration (MBC) and the Inhibitory Zone (IZ), against the bacterial strains Pseudomonas aeruginosa (PAO1) and Staphylococcus aureus (St. aureus) which settle in the cornea, in bacterial keratitis. The MICs' of AGMNA against PAO1 and St. Read More

Am J Ophthalmol Case Rep 2018 Dec 12;12:73-75. Epub 2018 Sep 12.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.

Purpose: To report the resolution of a fluoroquinolone-resistant keratitis with use of a prosthetic replacement of the ocular surface ecosystem (PROSE) device for enhanced targeted delivery of moxifloxiacin.

Observations: A 62-year-old female presented with a 3-day history of pain, photophobia, and declining vision in left eye. The patient had a 2-year history of binocular PROSE treatment for ocular chronic graft-vs-host disease (cGVHD). Read More

Arch Soc Esp Oftalmol 2019 Jan 27;94(1):4-11. Epub 2018 Sep 27.

Centro Oftalmológico Virgilio Galvis, Floridablanca, Colombia.

Background And Objective: In view of the increasing bacterial resistance to antibiotics, it is necessary to determine it locally in order to serve as a guide in clinical management. The purpose of this study was to characterise the pattern of antibiotic sensitivity in cases of eye infections in a third level ophthalmological institution in Floridablanca (Colombia).

Materials And Methods: An observational cross-sectional study in which an analysis was made of the culture and antibiogram reports of specimens taken from cases of conjunctivitis, infectious keratitis, and endophthalmitis between January 2013 and June 2016. Read More

Cornea 2018 Nov;37 Suppl 1:S99-S105

Department of Ophthalmology, Ehime University School of Medicine, Ehime, Japan.

Purpose: Pseudomonas aeruginosa produces pyoverdine, encoded by the pvdE gene, for high-affinity iron uptake from transferrin and lactoferrin. This study investigated the contribution of pyoverdine to P. aeruginosa keratitis pathogenesis using in vitro and in vivo models. Read More

Indian J Ophthalmol 2018 Oct;66(10):1478-1480

Department of Cornea, Anterior Segment and Refractive Services, C L Gupta Eye Institute, Ram Ganga Vihar Phase II, Moradabad, Uttar Pradesh, India.

We report a case of a 46-year-old female who developed infectious crystalline keratopathy (ICK) after Descemet's stripping endothelial keratoplasty (DSEK). She underwent DSEK for pseudophakic corneal edema in her left eye. Ten weeks after the procedure, the patient presented with complaints of blurred vision, redness in eye, and ocular pain. Read More

Exp Eye Res 2019 Jan 20;178:10-14. Epub 2018 Sep 20.

Universiti Kuala Lumpur, Malaysian Institute of Chemical and Engineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000, Alor Gajah, Melaka, Malaysia.

Microbial keratitis is the infection caused by pathogenic microorganisms that commonly occurs among the contact lens users. Various antimicrobial compounds were coated on contact lenses to kill keratitis causing microorganisms, however these compounds caused several adverse side effects. Hence, the aim of this study is to develop a silicone hydrogel contact lens coated with phomopsidione nanoparticle that inhibit keratitis causing clinical isolates. Read More

Cells 2018 Sep 20;7(10). Epub 2018 Sep 20.

Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, USA.

With increasing multidrug resistance and contraindication for corticosteroid use, the goal of this study was to develop thymosin beta-4 (Tβ4) as an adjunctive therapy to antibiotics for the treatment of bacterial keratitis that effectively promotes enhanced wound healing, host defense, and inflammation resolution. Disease outcome was assessed by clinical score, slit lamp photography, and histopathology. Cytokine profile, bacterial load, PMN infiltration, and Griess and reactive oxygen species (ROS) levels were determined. Read More

Am J Pathol 2018 Dec 18;188(12):2717-2728. Epub 2018 Sep 18.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan. Electronic address:

Ischemia is associated with the pathogenesis of retinal disease, including diabetic retinopathy and glaucoma. As a result, the retinal ischemia/reperfusion injury model has been used to study neurovascular changes. Historically, murine models of retinal disease are established in C57BL/6J (B6) mice, which have been described as type 1-dominant responders. Read More

Cornea 2018 Dec;37(12):1555-1560

Cornea Department, Manchester Royal Eye Hospital, Manchester, United Kingdom.

Purpose: Microbial keratitis (MK) is a major cause of corneal blindness worldwide. Variations in season and temperature can affect MK incidence due to specific causative organisms; however, few studies have examined these factors in the UK.

Methods: Retrospective review of all corneal scrapes from patients with MK presenting to Manchester Royal Eye Hospital, UK, between January 2004 and December 2015. Read More

Curr Eye Res 2018 Sep 19:1-10. Epub 2018 Sep 19.

d Institute of Ophthalmology , University College London , London , England.

Aim: To investigate the role of interleukin-17 in ocular surface and corneal disease. Ocular surface and corneal disease is a leading cause of blindness and is an ongoing challenge for the public health sector to implement effective therapies. The majority of cells in corneal lesions are derived primarily from neutrophils that induce inflammatory events that lead to tissue damage. Read More

Cornea 2018 Dec;37(12):1551-1554

Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.

Purpose: Changing trends of infective keratitis have been identified worldwide. The aim of this study was to define the clinical associations, characteristics, and outcomes of patients with culture-proven Moraxella keratitis from a large tertiary corneal unit in the United Kingdom.

Methods: Patients with confirmed Moraxella isolates presenting between January 2004 and November 2016 were analyzed. Read More