4,251 results match your criteria Keratitis Bacterial


Corneal cross-linking (CXL)-A clinical study to evaluate CXL as a treatment in comparison with medical treatment for ulcerative keratitis in horses.

Vet Ophthalmol 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Objective: Compare CXL treatment with medical treatment alone in horses with stromal, ulcerative keratitis.

Animals Studied: 24 horses (24 eyes) with stromal, ulcerative keratitis were included.

Procedure: 12 horses were initially treated with CXL, and 12 horses were given conventional medical treatment. Read More

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http://dx.doi.org/10.1111/vop.12662DOI Listing

Microbial Keratitis in Stevens-Johnson Syndrome: A Prospective Study.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To evaluate the microbiological profile and outcome in cases with infective keratitis in Stevens-Johnson syndrome (SJS).

Methods: Eighty-three eyes of 68 patients with SJS presenting with microbial keratitis were recruited and managed with standard antimicrobial therapy.

Results: Microbial keratitis developed in 34% of patients with SJS (83 eyes, 68 patients) over a period of 5 years. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001960DOI Listing
April 2019
1 Read

A New Topical Eye Drop Containing LyeTxI-b, A Synthetic Peptide Designed from A Venom Toxin, Was Effective to Treat Resistant Bacterial Keratitis.

Toxins (Basel) 2019 Apr 4;11(4). Epub 2019 Apr 4.

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901 MG, Brazil.

Bacterial keratitis is an ocular infection that can lead to severe visual disability. is a major pathogen of the eye. We recently demonstrated the strong antimicrobial activity of LyeTxI-b, a synthetic peptide derived from a toxin. Read More

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http://dx.doi.org/10.3390/toxins11040203DOI Listing
April 2019
6 Reads

Microbial Keratitis in Taiwan: A 20-Year update.

Am J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Purpose: To investigate the demographics, risk factors, microbiology and resistance pattern at a tertiary hospital and to detect the shifting trend over two decades.

Design: A retrospective observational case series.

Methods: We reviewed all records of patients with microbial keratitis (MK) that were hospitalized in National Taiwan University Hospital between 2007 and 2016. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.023DOI Listing
April 2019
1 Read

Evaluation of acute corneal damage induced by 222-nm and 254-nm ultraviolet light in Sprague-Dawley rats.

Free Radic Res 2019 Apr 5:1-151. Epub 2019 Apr 5.

a Department of Ophthalmology , Faculty of Medicine , Shimane University , Izumo , Japan.

Two hundred twenty-two nanometers ultraviolet (UV) light produced by a krypton-chlorine excimer lamp is harmful to bacterial cells but not skin. However, the effects of 222-nm UV light exposure to the eye are not fully known. We evaluated acute corneal damage induced by 222- and 254-nm UV light in albino rats. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2019.1
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http://dx.doi.org/10.1080/10715762.2019.1603378DOI Listing
April 2019
4 Reads

keratitis: passive immunotherapy with antibodies raised against divalent flagellin.

Iran J Basic Med Sci 2019 Jan;22(1):58-64

Medical Biotechnology Research Center, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.

Objectives: infections such as keratitis are considered among the major health problems worldwide due to the complexity of pathogenesis and antibiotic resistance crisis, thus, finding new effective approaches for prevention and treatment of the infections seem to be still vital. In this report, we aimed to investigate the therapeutic effects of topical administration of the antibodies against type a and b-flagellin (FLA and FLB) in keratitis model of infection in mice.

Materials And Methods: Scratched corneas of mice were treated with approximately 10 CFUs/eye of PAK and/or PAO1 strains of . Read More

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http://dx.doi.org/10.22038/ijbms.2018.31499.7643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437458PMC
January 2019
1 Read

Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion.

Cell Host Microbe 2019 Apr 28;25(4):526-536.e4. Epub 2019 Mar 28.

University of Calgary, Department of Physiology and Pharmacology, Calvin Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary, AB, Canada. Electronic address:

Bacterial biofilm infections are difficult to eradicate because of antibiotic insusceptibility and high recurrence rates. Biofilm formation by Pseudomonas aeruginosa, a leading cause of bacterial keratitis, is facilitated by the bacterial Psl exopolysaccharide and associated with heightened virulence. Using intravital microscopy, we observed that neutrophilic recruitment to corneal infections limits P. Read More

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http://dx.doi.org/10.1016/j.chom.2019.02.007DOI Listing
April 2019
1 Read

Molecular characterization of bacterial, viral and fungal endosymbionts of Acanthamoeba isolates in keratitis patients of Iran.

Exp Parasitol 2019 Mar 24;200:48-54. Epub 2019 Mar 24.

Division of Molecular Biology & Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Free-living amoebae belong to the genus Acanthamoeba; can feed on microbial population by phagocytosis, and with the capability to act as a reservoir and a vehicle of microorganisms to susceptible host. Therefore, the role of endosymbiosis in the pathogenesis of Acanthamoeba is complex and not fully understood. The aim of the present study was to identify bacterial, fungal, and human adenovirus (HADV) endosymbionts as well as evaluating the endosymbionts role of such organisms in the pathogenesis of Acanthamoeba in keratitis patients living in Iran. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.03.013DOI Listing

Visual impairment in fungal versus bacterial corneal ulcers four years after successful antimicrobial treatment.

Am J Ophthalmol 2019 Mar 19. Epub 2019 Mar 19.

Department of Ophthalmology; Francis I. Proctor Foundation. Electronic address:

Purpose: To compare longitudinal visual acuity outcomes of fungal corneal ulcers with those of bacterial ulcers.

Design: Prospective cohort study SETTING: Tertiary eye hospital in South India STUDY POPULATION: 100 individuals who had been diagnosed four years prior with either fungal or bacterial keratitis and had been enrolled in one of two concurrent randomized trials, out of 152 consecutive participants eligible for the study.

Exposure: Causative organism of infectious keratitis (bacteria versus fungus) MAIN OUTCOME MEASURES: Presenting visual acuity, best spectacle corrected visual acuity (BSCVA), and hard contact lens-corrected visual acuity (CLVA). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.010DOI Listing

Predicting factors and prediction model for discriminating between fungal infection and bacterial infection in severe microbial keratitis.

PLoS One 2019 20;14(3):e0214076. Epub 2019 Mar 20.

Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

A retrospective medical record review including 344 patients who were admitted with severe microbial keratitis at Ramathibodi Hospital, Bangkok, Thailand, from January 2010 to December 2016 was conducted. Causative organisms were identified in 136 patients based on positive culture results, pathological reports and confocal microscopy findings. Eighty-six eyes (63. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214076PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426210PMC

Equine ulcerative keratitis with furrow: A review of the outcomes of 72 cases from 1987 to 2015.

Equine Vet J 2019 Mar 18. Epub 2019 Mar 18.

Comparative Ophthalmology, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.

Background: Ulcerative keratitis with peripheral furrow formation is a poorly-described condition which has been associated with a grave prognosis due to rapid necrosis of the cornea.

Objective: To describe the infectious aetiologies associated with furrow-forming ulcerative keratitis, its overall clinical course and the efficacy of medical and surgical intervention in horses.

Study Design: Retrospective clinical case series. Read More

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http://dx.doi.org/10.1111/evj.13101DOI Listing

Differential Expression of Antimicrobial Peptides in Streptococcus pneumoniae Keratitis and STAT3-Dependent Expression of LL-37 by Streptococcus pneumoniae in Human Corneal Epithelial Cells.

Pathogens 2019 Mar 6;8(1). Epub 2019 Mar 6.

Prof. Brien Holden Eye Research Center, LV Prasad Eye Institute, Hyderabad 500034, India.

is the leading cause of bacterial keratitis in the developing world with a growing trend of acquiring resistance against various antibiotics. In the current study, we determined the expression of different antimicrobial peptides (AMPs) in response to in patients, as well as in primary and immortalized human corneal epithelial cells. We further focused on LL-37 and determined its expression in human cornea infected with and studied the killing ability of LL-37 against The expression of AMPs was determined by quantitative PCR and the phosphorylation of signaling proteins was evaluated by immunoblot analysis. Read More

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http://dx.doi.org/10.3390/pathogens8010031DOI Listing
March 2019
1 Read

Endophthalmitis associated with fungal keratitis and penetrating injuries in North China.

Eur J Ophthalmol 2019 Mar 4:1120672119833896. Epub 2019 Mar 4.

3 Clinical Lab of Qilu Hospital (Qingdao), Shandong University, Qingdao, P.R.China.

Purpose:: To report the laboratory findings, management strategies, and visual outcomes of culture-proven exogenous fungal endophthalmitis in North China.

Methods:: The microbiological and treatment records of patients with culture-positive exogenous fungal endophthalmitis who visited the Affiliated Hospital of Qingdao University from January 2012 to December 2016 were reviewed.

Results:: A total of 39 eyes (39 patients) were identified over a 5-year period. Read More

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http://dx.doi.org/10.1177/1120672119833896DOI Listing
March 2019
3 Reads

Staphylococcus aureus alpha-hemolysin impairs corneal epithelial wound healing and promotes intracellular bacterial invasion.

Exp Eye Res 2019 Apr 27;181:263-270. Epub 2019 Feb 27.

Stem Cell Therapy and Corneal Tissue Engineering Laboratory, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1905 W. Taylor St., L-213, Chicago, IL, 60612, United States. Electronic address:

Colonization by Staphylococcus aureus (S. aureus) has been implicated in many infectious and wound healing disorders. This study was performed to characterize the pathogenic role of S. Read More

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http://dx.doi.org/10.1016/j.exer.2019.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447303PMC
April 2019
6 Reads
2.709 Impact Factor

Ten-year analysis of microbiological profile and antibiotic sensitivity for bacterial keratitis in Korea.

PLoS One 2019 1;14(3):e0213103. Epub 2019 Mar 1.

Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea.

Purpose: To investigate the risk factors, microbiological profiles, antibiotic susceptibility patterns, and treatment outcome in patients with bacterial keratitis at a Korean tertiary hospital.

Methods: A retrospective chart review was performed of patients who were diagnosed with infectious keratitis and underwent corneal scrapings for cultures at Seoul National University Hospital between 2007 and 2016. Demographics, clinical characteristics, microbiological data, antibiotic resistance and sensitivity, and treatment outcome were collected. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213103PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396910PMC
March 2019
3 Reads

Corneal lymphangiogenesis ameliorates corneal inflammation and edema in late stage of bacterial keratitis.

Sci Rep 2019 Feb 27;9(1):2984. Epub 2019 Feb 27.

Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

Lymphatic vessels play a crucial role in systemic immune response and regulation of tissue fluid homeostasis. Corneal lymphangiogenesis in bacterial keratitis has not been studied. In this study, we investigated the mechanism and the role of corneal lymphangiogenesis in a murine bacterial keratitis model using Pseudomonas aeruginosa. Read More

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http://dx.doi.org/10.1038/s41598-019-39876-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393676PMC
February 2019
2 Reads

Conjunctival microbiome changes associated with fungal keratitis: metagenomic analysis.

Int J Ophthalmol 2019 18;12(2):194-200. Epub 2019 Feb 18.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, China.

Aim: To investigate the ocular surface microbiome profile of patients with fungal keratitis (FK) through bacterial 16S rDNA sequencing.

Methods: The swab samples were collected from 8 patients with FK (Group 1 from the corneal ulcer, Group 2 from the conjunctival sac of the infected eyes, and Group 3 from the conjunctival sac of the fellow eyes) and 10 healthy eyes (Group 4 from the conjunctival sac). Bacterial 16S rDNA V4-V5 region sequencing was performed to characterize the bacterial communities on the ocular surfaces of the patients with FK. Read More

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http://dx.doi.org/10.18240/ijo.2019.02.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376244PMC
February 2019

Mechanisms of Fluoroquinolone and Aminoglycoside Resistance in Keratitis-Associated Pseudomonas aeruginosa.

Microb Drug Resist 2019 Feb 26. Epub 2019 Feb 26.

1 Department of Ocular Microbiology and Aravind Medical Research Foundation, Madurai, India.

Global emergence of multidrug resistant (MDR) strains limits therapeutic efficacy in Pseudomonas aeruginosa corneal ulcers. Identifying the primary causal factors of resistance shall improve clinical management. In this study, we sought to identify the underlying mechanisms of fluoroquinolone and aminoglycoside resistance in MDR, non-MDR, and drug susceptible P. Read More

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http://dx.doi.org/10.1089/mdr.2018.0218DOI Listing
February 2019
1 Read

Povidone-iodine concentration and in vitro killing time of bacterial corneal ulcer isolates.

Digit J Ophthalmol 2018 19;24(4):24-26. Epub 2018 Dec 19.

Albany Medical College, Albany, New York.

Background: The concentration and dosing of povidone-iodine (PI) solution used in surgical site prophylaxis are variable. Prior in vitro work has demonstrated that dilute PI solutions (<1%) had greater bactericidal activity than stock solutions (10%). Studies using pathologic clinical isolates from the eye have yielded mixed results. Read More

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http://dx.doi.org/10.5693/djo.01.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380258PMC
March 2019
1 Read

Antimicrobial Activity of Diacerein on 76 Isolates of Gram-Positive Cocci from Bacterial Keratitis Patients and Study of Diacerein Eye Drops on Staphylococcus aureus Keratitis in Mice.

Antimicrob Agents Chemother 2019 Apr 27;63(4). Epub 2019 Mar 27.

Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China

Bacterial keratitis is an aggressive infectious corneal disease. With the continuing rise in antibiotic resistance and a decline in the discovery of new antibiotics, new antimicrobial drugs are now required. In the present study, we determined the antibacterial activity of diacerein, an anti-inflammatory drug, against 76 Gram-positive cocci isolated from bacterial keratitis patients and anti- activity in a mouse bacterial keratitis model The MICs of diacerein were tested using the broth microdilution method A BALB/c keratitis animal model was selected and the corneal clinical observation, viable bacteria, and hematoxylin-eosin and Gram staining of infected corneas were measured to evaluate the antibacterial efficacy of diacerein eye drops An eye irritation study was carried out by a modified Draize test in rabbits. Read More

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http://dx.doi.org/10.1128/AAC.01874-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437483PMC
April 2019
10 Reads

Clinical and microbiological characteristics of Moraxella keratitis.

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland

Background/aims: To describe the risk factors, clinical features, bacterial subspecies characteristics and treatment outcomes of Moraxella keratitis in a single centre.

Methods: A retrospective review of all patients diagnosed with Moraxella keratitis between November 2012 and December 2017 at the Royal Victoria Eye and Ear Hospital, Dublin, Ireland was performed. Matrix-assisted laser desorption ionisation time-of-flight (MALDI-TOF) mass spectrometry was used to identify subspecies. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313557DOI Listing
February 2019
2 Reads

Frontline Science: Employing enzymatic treatment options for management of ocular biofilm-based infections.

J Leukoc Biol 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Pseudomonas aeruginosa-induced corneal keratitis is a sight-threatening disease. The rise of antibiotic resistance among P. aeruginosa keratitis isolates makes treatment of this disease challenging, emphasizing the need for alternative therapeutic modalities. Read More

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http://dx.doi.org/10.1002/JLB.4HI0918-364RRDOI Listing
January 2019

Bacterial and Fungal Keratitis: A Retrospective Analysis at a University Hospital in Switzerland.

Klin Monbl Augenheilkd 2019 Apr 7;236(4):358-365. Epub 2019 Jan 7.

Universitätsklinik für Augenheilkunde, Inselspital, Bern, Schweiz.

Background: Infectious keratitis is a serious corneal disease and may lead to permanent visual deterioration if not treated rapidly and effectively. In order to determine possible changes in the spectrum of pathogens over time, we evaluated the pathogenic organisms of keratitis at a university hospital in Switzerland, comparing two time periods within a decade.

Methods: In this retrospective study, 417 patients with the clinical diagnosis of bacterial or fungal keratitis in 2006/07 and 2015/16 were enrolled. Read More

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http://dx.doi.org/10.1055/a-0774-7756DOI Listing
April 2019
11 Reads

Queensland Microbial Keratitis Database: 2005-2015.

Br J Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

School of Optometry and Vision Science, University of New South Wales, Kensington, Queensland, Australia.

Aims: To estimate the incidence of culture-positive microbial keratitis in Queensland and analyse trends in the organisms and their sensitivities cultured from corneal scrapes, especially low-incidence organisms.

Methods: Retrospective multicentre case series of all positive corneal scrapes in Queensland, Australia between 2005 and 2015. Pathology organisations in Queensland were identified by online and local directory search and agreed to participate. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3128
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-312881DOI Listing
January 2019
10 Reads

The persistent dilemma of microbial keratitis: Global burden, diagnosis, and antimicrobial resistance.

Surv Ophthalmol 2018 Dec 24. Epub 2018 Dec 24.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA; Infectious Disease Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Microbial keratitis is a potentially blinding condition that must be treated emergently to preserve vision. Although long recognized as a significant cause of corneal blindness, our understanding of its true global scale, associated burden of disease, and etiological patterns remains somewhat limited. Current epidemiological data suggest that microbial keratitis may be epidemic in parts of the world-particularly within South, South-East, and East Asia-and may exceed 2 million cases per year worldwide. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396257183021
Publisher Site
http://dx.doi.org/10.1016/j.survophthal.2018.12.003DOI Listing
December 2018
14 Reads

Shewanella algae keratitis.

Indian J Ophthalmol 2019 Jan;67(1):148-150

Department of Ophthalmology, The University of Texas Medical Branch College of Medicine, Galveston; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston; Department of Ophthalmology, Houston Methodist Eye Associates, Houston Methodist Hospital, Houston, TX; Department of Ophthalmology, Weill Cornell Medicine, New York, NY, USA.

A 75-year-old male with a right eye history of chronic dry eye syndrome, glaucoma status post tube shunt, and Fuchs dystrophy status post Descemet stripping endothelial keratoplasty followed by penetrating keratoplasty (PKP) presented with a 2.7 × 4.2 mm corneal ulcer, culture positive for Shewanella algae and Klebsiella oxytoca. Read More

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http://dx.doi.org/10.4103/ijo.IJO_617_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324159PMC
January 2019
3 Reads

Types of organisms and susceptibility of bacterial isolates from patients with microbial keratitis: A trend analysis of 8 years.

Indian J Ophthalmol 2019 Jan;67(1):49-53

Jhaveri Microbiology Centre, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To report the distribution and trends of types of organisms and antibiotic susceptibility of the bacterial isolates obtained from patients with microbial keratitis.

Methods: Microbiology records of culture-positive microbial keratitis that underwent a diagnostic corneal scraping and cultures were reviewed. Fungal, bacterial, and parasitic culture results and antibiotic susceptibility profile of bacteria were analyzed and comparisons were made between two halves of the study period (2007-2010 vs. Read More

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http://www.ijo.in/text.asp?2019/67/1/49/248148
Publisher Site
http://dx.doi.org/10.4103/ijo.IJO_500_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324162PMC
January 2019
3 Reads
0.927 Impact Factor

Risk factors and clinical signs of severe keratitis.

Clin Ophthalmol 2018 10;12:2567-2573. Epub 2018 Dec 10.

Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, Saitama, Japan,

Purpose: To determine risk factors and clinical signs for severe keratitis (AK) by comparing severe cases with mild cases with good prognosis.

Patients And Methods: We reviewed medical records of ten cases of AK (five males and five females) referred to our hospital and classified cases into two groups. One eye that required therapeutic keratoplasty and three eyes with a poor visual acuity (<0. Read More

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http://dx.doi.org/10.2147/OPTH.S179360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292401PMC
December 2018
2 Reads

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5993-6002

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, United States.

Purpose: Pseudomonas aeruginosa is the leading cause of contact lens-associated bacterial keratitis. Secreted bacterial proteases have a key role in keratitis, including the P. aeruginosa small protease (PASP), a proven corneal virulence factor. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
Publisher Site
http://dx.doi.org/10.1167/iovs.18-25834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306078PMC
December 2018
22 Reads

and keratitis in a contact lens user.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Microbiology, Aravind Eye Hospital Coimbatore, Coimbatore, Tamil Nadu, India.

The oomycete and the protozoan can cause fulminant and recalcitrant keratitis, respectively. These infections are not only sight-threatening but can also threaten the structural integrity of the eye. A high index of suspicion is required to identify keratitis given its uncommon occurrence. Read More

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http://dx.doi.org/10.1136/bcr-2018-226386DOI Listing
December 2018
3 Reads

NLRP12 promotes host resistance against Pseudomonas aeruginosa keratitis inflammatory responses through the negative regulation of NF-κB signaling.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8063-8075

Department of Laboratory, Longhua District Central Hospital, Longhua District, Shenzhen, China.

Objective: To investigate the role of NLRP12 in regulating Pseudomonas aeruginosa (P. aeruginosa) keratitis.

Materials And Methods: Real-Time-PCR and Western blot were performed to measure the NLRP12 level in corneas and bone marrow-derived macrophages (BMDMs) of C57BL/6 (B6) mice. Read More

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http://dx.doi.org/10.26355/eurrev_201812_16496DOI Listing
December 2018

Alterations in gut bacterial and fungal microbiomes are associated with bacterial Keratitis, an inflammatory disease of the human eye.

J Biosci 2018 Dec;43(5):835-856

Jhaveri Microbiology Centre, Prof. Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Kallam Anji Reddy campus, Hyderabad 500 034, India.

Dysbiosis, or imbalance in the gut microbiome, has been implicated in auto-immune, inflammatory, neurological diseases as well as in cancers. More recently it has also been shown to be associated with ocular diseases. In the present study, the association of gut microbiome dysbiosis with bacterial Keratitis, an inflammatory eye disease which significantly contributes to corneal blindness, was investigated. Read More

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December 2018
1 Read
2.064 Impact Factor

The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.

Interdiscip Perspect Infect Dis 2018 13;2018:2525173. Epub 2018 Nov 13.

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. Read More

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https://www.hindawi.com/journals/ipid/2018/2525173/
Publisher Site
http://dx.doi.org/10.1155/2018/2525173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257906PMC
November 2018
12 Reads

VIP modulates the ALX/FPR2 receptor axis toward inflammation resolution in a mouse model of bacterial keratitis.

Prostaglandins Other Lipid Mediat 2019 02 4;140:18-25. Epub 2018 Dec 4.

Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, United States. Electronic address:

Vasoactive intestinal peptide (VIP) has been shown to regulate corneal inflammation. Formyl peptide receptor 2 (FPR2) is a transmembrane protein belonging to the GPCR family. Ligands include pro-resolving lipids, lipoxin A4 (LXA4) and resolvin D1 (RvD1). Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326851PMC
February 2019
4 Reads

[Therapeutic efficacy of ultraviolet combined with riboflavin for the rabbit bacterial keratitis].

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):902-910

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.

To study the effects of ultraviolet light combined with riboflavin treatment (corneal collagen-crosslinking, CXL) on infectious control and stromal reconstruction of bacterial keratitis. Experimental Study. A Staphylococcus aureus rabbit keratitis model was established by injecting Staphylococcus aureus broth into the shallow stromal layer of the right eye cornea of New Zealand white rabbits. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.12.007DOI Listing
December 2018
2 Reads

A presentation of culture-positive corneal donors and the effect on clinical outcomes.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 30;257(1):135-141. Epub 2018 Nov 30.

Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.

Purpose: Donor-to-host transmission of infectious agents is a rare but well-recognised complication of corneal transplantation and may carry a grave visual prognosis. In this case series, we describe the clinical features and risk factors of using culture-positive donor corneas for transplantation.

Methods: Retrospective chart review of a series of patients who underwent either penetrating keratoplasty (PK) or Descemet's stripping automated endothelial keratoplasty (DSAEK) with positive microbiology cultivation during routine assessment of donor corneal tissue obtained at the time of surgery. Read More

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http://dx.doi.org/10.1007/s00417-018-4200-9DOI Listing
January 2019
3 Reads

The epidemiology of nonviral microbial keratitis in a tertiary care center in Muscat, Oman.

Oman J Ophthalmol 2018 Sep-Dec;11(3):213-219

Department of Ophthalmology, Al-Nahdah Hospital, Muscat, Oman.

Objective: The objective of this study is to describe the epidemiology, risk factors, etiology, and outcome of microbial keratitis in a tertiary care center in Muscat, Oman.

Methods: The electronic records of all patients diagnosed with keratitis or corneal ulcer between January 2013 and January 2016 in Al-Nahdha Hospital were retrospectively reviewed. Patients who presented with a corneal ulcer requiring admission and who underwent culture and sensitivity studies were included in the study. Read More

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http://dx.doi.org/10.4103/ojo.OJO_4_2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219341PMC
December 2018
4 Reads

Analysis of penetrating keratoplasty in Northern Alberta, Canada, from 2000 to 2015.

Can J Ophthalmol 2018 Dec 10;53(6):568-573. Epub 2018 Apr 10.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address:

Objective: To study indications for penetrating keratoplasty (PK) at a single site. The trends in the causative organisms for infectious keratitis requiring surgery were also evaluated.

Design: Retrospective observational study. Read More

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http://dx.doi.org/10.1016/j.jcjo.2018.01.024DOI Listing
December 2018
4 Reads
1.299 Impact Factor

Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors.

PLoS One 2018 28;13(11):e0208163. Epub 2018 Nov 28.

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

To investigate the clinical characteristics, treatment, risk factors of occurrence and graft transparency of corneal epithelial defects after penetrating keratoplasty in patients with infectious keratitis. 594 patients (594 eyes) with infectious keratitis treated by penetrating keratoplasty at Shandong Eye Institute were reviewed retrospectively between January 2008 and January 2018. We investigated the demographic data, diameter and sources of graft, onset time, location, scope, time of healing and treatment of epithelial defects, as well as other postoperative complications and graft clarity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208163PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261636PMC
November 2018
14 Reads

Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii.

Parasit Vectors 2018 Nov 26;11(1):604. Epub 2018 Nov 26.

Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.

Background: Acanthamoeba spp. can cause serious human infections, including Acanthamoeba keratitis, granulomatous amoebic encephalitis and cutaneous acanthamoebiasis. Cysteine biosynthesis and the L-serine metabolic pathway play important roles in the energy metabolism of Acanthamoeba spp. Read More

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http://dx.doi.org/10.1186/s13071-018-3188-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257972PMC
November 2018
3 Reads

Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome.

Exp Parasitol 2019 Jan 22;196:22-27. Epub 2018 Nov 22.

University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Island, Spain.

Acanthamoeba keratitis (AK) is a sight-threatening corneal infection. The early symptoms include redness, pain, photophobia and intense tearing. Chronic infection usually progresses to stromal inflammation, ring ulcers, corneal opacification and hypopyon. Read More

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http://dx.doi.org/10.1016/j.exppara.2018.11.005DOI Listing
January 2019
3 Reads

A novel murine model for contact lens wear reveals clandestine IL-1R dependent corneal parainflammation and susceptibility to microbial keratitis upon inoculation with Pseudomonas aeruginosa.

Ocul Surf 2019 Jan 12;17(1):119-133. Epub 2018 Nov 12.

School of Optometry, University of California, Berkeley, CA, 94720, USA; Graduate Group in Vision Science, University of California, Berkeley, CA, 94720, USA; Graduate Groups in Microbiology, Infectious Diseases & Immunity, University of California, Berkeley, CA, 94720, USA. Electronic address:

Purpose: Contact lens wear carries a risk of complications, including corneal infection. Solving these complications has been hindered by limitations of existing animal models. Here, we report development of a new murine model of contact lens wear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15420124183022
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http://dx.doi.org/10.1016/j.jtos.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365008PMC
January 2019
26 Reads

Microbiological Evaluation of Bandage Soft Contact Lenses Used in Management of Persistent Corneal Epithelial Defects.

Cornea 2019 Feb;38(2):146-150

Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To investigate the rate and agents of contamination in bandage soft contact lenses fitted for management of persistent corneal epithelial defects.

Methods: This prospective comparative case series enrolled 57 consecutive eyes fitted with bandage contact lenses for treatment of persistent corneal epithelial defects. The lenses were collected at the time of epithelial closure or when it was necessary to exchange contact lenses and were immediately placed in sterile tubes containing an enriched thioglycolate liquid medium. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001810DOI Listing
February 2019
23 Reads

Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections.

Antimicrob Agents Chemother 2019 Jan 21;63(1). Epub 2018 Dec 21.

Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

and are two of the most common causes of bacterial keratitis and corresponding corneal blindness. Accordingly, such infections are predominantly treated with broad-spectrum fluoroquinolones, such as moxifloxacin. Yet, the rising fluoroquinolone resistance has necessitated the development of alternative therapeutic options. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01929-18
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http://dx.doi.org/10.1128/AAC.01929-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325218PMC
January 2019
10 Reads

HMGB1 Antagonist, Box A, Reduces TLR4, RAGE, and Inflammatory Cytokines in the Cornea of P. aeruginosa-Infected Mice.

J Ocul Pharmacol Ther 2018 Nov 8. Epub 2018 Nov 8.

1 Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine , Detroit, Michigan.

Purpose: High mobility group box 1 (HMGB1) contributes to adverse disease outcome in Pseudomonas aeruginosa keratitis. This study tests Box A, an HMGB1 antagonist, in a model of the disease.

Methods: C57BL/6 mice (B6) were injected subconjunctivally (1 day before infection) with Box A or phosphate-buffered saline (PBS), infected with P. Read More

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https://www.liebertpub.com/doi/10.1089/jop.2018.0073
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http://dx.doi.org/10.1089/jop.2018.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302910PMC
November 2018
7 Reads

Infectious Keratitis: Microbiological Review of 297 Cases.

Jpn J Infect Dis 2019 Mar 31;72(2):121-123. Epub 2018 Oct 31.

Section of Microbiology, University Hospital of Guadalajara.

Infectious keratitis is a serious ocular infection that can lead to loss of vision. The aim of this study was to investigate the microbiological characteristics of this infection at the University Hospital of Guadalajara (Spain). We retrospectively reviewed all cases diagnosed between January 2010 and December 2016. Read More

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https://www.jstage.jst.go.jp/article/yoken/advpub/0/advpub_J
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http://dx.doi.org/10.7883/yoken.JJID.2018.269DOI Listing
March 2019
6 Reads

Identification of Moraxella lacunata from pulmonary abscesses in three zoo herbivores.

J Vet Med Sci 2018 Dec 29;80(12):1914-1917. Epub 2018 Oct 29.

College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.

Although Moraxella lacunata causes conjunctivitis, keratitis, endocarditis, and otolaryngitis in humans, its infection is rare in animals. We report three cases of asymptomatic pulmonary abscesses caused by M. lacunata in zoo herbivores, including two elks (Cervus canadensis) and a common eland (Taurotragus oryx). Read More

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https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_18
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http://dx.doi.org/10.1292/jvms.18-0455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305504PMC
December 2018
10 Reads

Bacterial Keratitis Preferred Practice Pattern®.

Ophthalmology 2019 Jan 23;126(1):P1-P55. Epub 2018 Oct 23.

Departments of Cornea and External Diseases, Scripps Clinic Torrey Pines, La Jolla, California.

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https://linkinghub.elsevier.com/retrieve/pii/S01616420183264
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http://dx.doi.org/10.1016/j.ophtha.2018.10.018DOI Listing
January 2019
3 Reads