45,174 results match your criteria Kennedy Disease


Fruit for thought: anaphylaxis to fruit pectin in foods.

J Allergy Clin Immunol Pract 2018 Dec 12. Epub 2018 Dec 12.

Division of Allergy & Immunology, Children's Hospital of Philadelphia, Philadelphia, PA; Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA.

Clinical Implications: Pectin is a structural heteropolysaccharide previously associated with occupational asthma and only rare accounts of allergy. Few case reports, however, suggest that pectin may contribute to atypical or idiopathic food reactions, particularly in patients with IgE-mediated allergy to tree nuts. Read More

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December 2018

Association Between Red Blood Cell Transfusion and Clinical Outcomes Among Patients Undergoing Transcatheter Aortic Valve Replacement.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Cardiology and Cardiothoracic Surgery, Alpert Medical School of Brown University, Providence, RI.

Background: We evaluated the association between post-procedural packed red blood cell (PRBC) transfusion and morbidity and mortality in patients undergoing transcatheter aortic valve replacement (TAVR).

Methods: We retrospectively analyzed 429 patients with severe aortic stenosis (AS), who underwent TAVR. Propensity-score adjusted multivariable logistic and Cox regression models were used to determine the association of PRBC transfusion to the composite endpoint of death, myocardial infarction (MI) or stroke at 30 days, in-hospital, and 1-year mortality. Read More

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December 2018

Substance Use and Depression Among Recently Migrated African Gay and Bisexual Men Living in the United States.

J Immigr Minor Health 2018 Dec 14. Epub 2018 Dec 14.

HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Unit 15, New York, NY, 10032, USA.

Immigrant African gay and bisexual men (GBM) are at risk for substance use and adverse mental health outcomes due to negative experiences in home and host countries. Little is known about correlates of substance use and mental health outcomes in this population. We explored pre- and post-migratory factors associated with substance use and depression in recently migrated African GBM. Read More

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December 2018

Motor Cortex Excitability Reflects the Subjective Value of Reward and Mediates its Effects on Incentive Motivated Performance.

J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA

Performance-based incentives tend to increase an individual's motivation, resulting in enhancements in behavioral output. While much work has focused on understanding how the brain's reward circuitry influences incentive motivated performance, fewer studies have investigated how such reward representations act on the motor system. Here we measured motor cortical excitability with transcranial magnetic stimulation (TMS) while female and male human participants performed a motoric incentive motivation task for prospective monetary gains and losses. Read More

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December 2018

Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?

Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

Objectives: Controlled immune responses rely on integrated crosstalk between cells and their microenvironment. We investigated whether targeting proinflammatory signals from the extracellular matrix that persist during pathological inflammation provides a viable strategy to treat rheumatoid arthritis (RA).

Methods: Monoclonal antibodies recognising the fibrinogen-like globe (FBG) of tenascin-C were generated by phage display. Read More

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December 2018

A versatile mouse model of epitope-tagged histone H3.3 to study epigenome dynamics.

J Biol Chem 2018 Dec 14. Epub 2018 Dec 14.

Nat'l Inst of Child Health & Human Developoment, Division of Developmental Biology, National Institute of Child Health and Human Development, NIH, United States.

The variant histone H3.3 is incorporated into the genome in a transcription dependent manner. This histone is thus thought to play a role in epigenetic regulation. Read More

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December 2018

Cardiovascular and Metabolic Risk in Women in the First Year Postpartum: Allostatic Load as a Function of Race, Ethnicity, and Poverty Status.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine, UCLA Geffen School of Medicine, Los Angeles, California.

Objective:  Allostatic load (AL) represents multisystem physiological "wear-and-tear" reflecting emerging chronic disease risk. We assessed AL during the first year postpartum in a diverse community sample with known health disparities.

Methods:  The Shriver National Institute for Child Health and Human Development Community Child Health Network enrolled 2,448 predominantly low-income African-American, Latina, and White women immediately after delivery of liveborn infants at ≥20 weeks' gestation, following them over time with interviews, clinical measures, and biomarkers. Read More

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December 2018

Subtle motor signs in children with chronic traumatic brain injury.

Am J Phys Med Rehabil 2018 Dec 13. Epub 2018 Dec 13.

Kennedy Krieger Institute.

Objective: To characterize subtle motor signs in children with moderate-severe traumatic brain injury (TBI) in the chronic phase of injury.

Design: Fourteen children with moderate (n=6) or severe (n=8) TBI, ages 11-18 years, who had sustained their injury at least 1-year prior to study participation (Range 1-14 years since injury), and 14 matched typically-developing controls were examined using the Physical and Neurological Examination of Subtle Signs (PANESS). To examine the neural correlates of subtle motor signs, measures of total cerebral volume and motor/premotor volume were derived from MRI. Read More

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December 2018
1 Read

"Same but different": Associations between multiple aspects of self-regulation, cognition, and academic abilities.

J Pers Soc Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology.

Self-regulation describes the ability to control both behaviors and internal states against a backdrop of conflicting or distracting situations, drives, or impulses. In the cognitive psychology tradition, individual differences in self-regulation are commonly measured with performance-based tests of executive functioning, whereas in the personality psychology tradition, individual differences in self-regulation are typically assessed with report-based measures of impulse control, sustained motivation, and perseverance. The goal of this project was (a) to comprehensively examine the structure of associations between multiple self-regulatory constructs stemming from the cognitive and personality psychology traditions; (b) to estimate how these constructs, individually and collectively, related to mathematics and reading ability beyond psychometric measures of processing speed and fluid intelligence; and (c) to estimate the extent to which genetic and environmental factors mediated the observed associations. Read More

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December 2018
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Catastrophic individuation failures in infancy: A new model and predictions.

Psychol Rev 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology.

Comparison of infant findings from the physical-reasoning and object-individuation literatures reveals a contradictory picture. On the one hand, physical-reasoning results indicate that young infants can use featural information to guide their actions on objects and to detect interaction violations (when objects interact in ways that are not physically possible) as well as change violations (when objects spontaneously undergo featural changes that are not physically possible). On the other hand, object-individuation results indicate that young infants typically cannot use featural information to detect individuation violations (when the number of objects revealed at the end of an event is less than the number of objects introduced during the event). Read More

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December 2018
7.972 Impact Factor

What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics.

J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.

Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario, Canada.

The International Society of Psychiatric Genetics (ISPG) created a Residency Education Committee with the purpose of identifying key genetic knowledge that should be taught in psychiatric training programs. Thirteen committee members were appointed by the ISPG Board of Directors, based on varied training, expertise, gender, and national origin. The Committee has met quarterly for the past 2 years, with periodic reports to the Board and to the members of the Society. Read More

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November 2018

Age but no sex effects on subareas of the amygdala.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

School of Psychology, University of Auckland, Auckland, New Zealand.

The amygdala, an anatomical composite of several nuclei that have been grouped anatomically and functionally into three major subareas, has been reported to decrease in size with increasing age and to differ in size between male and female brains. However, findings are rather inconsistent across existing studies, possibly reflecting differences in the cohorts examined or the approaches chosen to define and measure the dimensions of the amygdala. Here, we investigated possible effects of age and sex on the amygdala as well as age-by-sex interactions in 100 healthy subjects (50 men/50 women) aged 18-69 years. Read More

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December 2018
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Lactation intensity and duration to postpartum diabetes and prediabetes in women with gestational diabetes.

Diabetes Metab Res Rev 2018 Dec 13:e3115. Epub 2018 Dec 13.

Pennington Biomedical Research Center, Baton Rouge, LA.

Objective: To investigate the association of lactation intensity and duration with postpartum diabetes and prediabetes risks among Chinese women with a history of GDM.

Methods: We included 1260 women with a history of GDM who participated in the whole populationꞋs GDM universal screening survey by using World Health OrganizationꞋs criteria. Lactation intensity and lactation duration were collected by a standardized questionnaire. Read More

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December 2018
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Mortality and losses to follow-up among adolescents living with HIV in the IeDEA global cohort collaboration.

J Int AIDS Soc 2018 Dec;21(12):e25215

TREAT Asia/amfAR, The Foundation for AIDS Research, Bangkok, Thailand.

Introduction: We assessed mortality and losses to follow-up (LTFU) during adolescence in routine care settings in the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium.

Methods: Cohorts in the Asia-Pacific, the Caribbean, Central, and South America, and sub-Saharan Africa (Central, East, Southern, West) contributed data, and included adolescents living with HIV (ALHIV) enrolled from January 2003 and aged 10 to 19 years (period of adolescence) while under care up to database closure (June 2016). Follow-up started at age 10 years or the first clinic visit, whichever was later. Read More

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December 2018
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Kinetics of T-cell subset reconstitution following treatment with bendamustine and rituximab for low-grade lymphoproliferative disease: a population-based analysis.

Br J Haematol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Delayed lymphocyte and T-cell immune reconstitution following bendamustine-rituximab (BR) for indolent non-Hodgkin lymphoma (iNHL) has been described, but no information is available for chronic lymphocytic leukaemia (CLL). We present a population-based retrospective analysis of immune reconstitution and risk of infection following BR. Outcomes included timing/correlates of CD4+ recovery and risk of ≥grade 3 infections. Read More

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December 2018

Evaluating different values of effort and reinforcement parameters under concurrent- and single-operant arrangements.

J Appl Behav Anal 2018 Dec 12. Epub 2018 Dec 12.

University of Maryland, Baltimore County.

If particular parameters (e.g., reinforcer quality) are found to be preferred in a concurrent-operant arrangement, then these should be incorporated into interventions for maintaining skills in individuals with intellectual disabilities. Read More

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December 2018

The nature of the association between number line and mathematical performance: An international twin study.

Br J Educ Psychol 2018 Dec 11. Epub 2018 Dec 11.

Laboratory for Cognitive Investigations and Behavioral Genetics, Department of Psychology, Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Tomsk, Oblast, Russia.

Background: The number line task assesses the ability to estimate numerical magnitudes. People vary greatly in this ability, and this variability has been previously associated with mathematical skills. However, the sources of individual differences in number line estimation and its association with mathematics are not fully understood. Read More

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December 2018

The role of polysomnography in decannulation of children with brain and spinal cord injuries.

Pediatr Pulmonol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatric Rehabilitation Medicine, Kennedy Krieger Institute, Baltimore, Maryland.

Objective: The objective of this retrospective review was to determine the utility of polysomnography (PSG) in influencing the decision to decannulate pediatric patients with brain and spinal cord injuries in an inpatient rehabilitation hospital setting.

Methods: Between 2010 and 2016, data were collected on pediatric patients with brain and/or spinal cord injuries who had PSG performed with the goal of decannulation. Patients underwent a decannulation protocol involving toleration of continuous tracheostomy capping and bedside tracheoscopy by otolaryngology. Read More

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December 2018

fMRI activation optimization in the setting of brain tumor-induced neurovascular uncoupling using resting state BOLD ALFF.

Brain Connect 2018 Dec 14. Epub 2018 Dec 14.

Johns Hopkins University School of Medicine, Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, Maryland, United States.

Aim: To demonstrate that a novel resting state BOLD ALFF (the amplitude of low-frequency fluctuation)-based correction method can substantially enhance the detectability of motor task activation in the presence of tumor-induced neurovascular uncoupling (NVU).

Methods: Twelve de novo brain tumor patients who underwent comprehensive clinical BOLD fMRI exams including task fMRI and resting state fMRI (rsfMRI) were evaluated. Each patient displayed decreased/absent task fMRI activation in the primary ipsilesional primary motor cortex in the absence of corresponding motor deficit or suboptimal task performance, consistent with NVU. Read More

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December 2018

Evidence for the Associated Production of a Single Top Quark and a Photon in Proton-Proton Collisions at sqrt[s]=13  TeV.

Authors:
A M Sirunyan A Tumasyan W Adam F Ambrogi E Asilar T Bergauer J Brandstetter M Dragicevic J Erö A Escalante Del Valle M Flechl R Frühwirth V M Ghete J Hrubec M Jeitler N Krammer I Krätschmer D Liko T Madlener I Mikulec N Rad H Rohringer J Schieck R Schöfbeck M Spanring D Spitzbart A Taurok W Waltenberger J Wittmann C-E Wulz M Zarucki V Chekhovsky V Mossolov J Suarez Gonzalez E A De Wolf D Di Croce X Janssen J Lauwers M Pieters H Van Haevermaet P Van Mechelen N Van Remortel S Abu Zeid F Blekman J D'Hondt I De Bruyn J De Clercq K Deroover G Flouris D Lontkovskyi S Lowette I Marchesini S Moortgat L Moreels Q Python K Skovpen S Tavernier W Van Doninck P Van Mulders I Van Parijs D Beghin B Bilin H Brun B Clerbaux G De Lentdecker H Delannoy B Dorney G Fasanella L Favart R Goldouzian A Grebenyuk A K Kalsi T Lenzi J Luetic N Postiau E Starling L Thomas C Vander Velde P Vanlaer D Vannerom Q Wang T Cornelis D Dobur A Fagot M Gul I Khvastunov D Poyraz C Roskas D Trocino M Tytgat W Verbeke B Vermassen M Vit N Zaganidis H Bakhshiansohi O Bondu S Brochet G Bruno C Caputo P David C Delaere M Delcourt B Francois A Giammanco G Krintiras V Lemaitre A Magitteri A Mertens M Musich K Piotrzkowski A Saggio M Vidal Marono S Wertz J Zobec F L Alves G A Alves M Correa Martins Junior G Correia Silva C Hensel A Moraes M E Pol P Rebello Teles E Belchior Batista Das Chagas W Carvalho J Chinellato E Coelho E M Da Costa G G Da Silveira D De Jesus Damiao C De Oliveira Martins S Fonseca De Souza H Malbouisson D Matos Figueiredo M Melo De Almeida C Mora Herrera L Mundim H Nogima W L Prado Da Silva L J Sanchez Rosas A Santoro A Sznajder M Thiel E J Tonelli Manganote F Torres Da Silva De Araujo A Vilela Pereira S Ahuja C A Bernardes L Calligaris T R Fernandez Perez Tomei E M Gregores P G Mercadante S F Novaes Sandra S Padula A Aleksandrov R Hadjiiska P Iaydjiev A Marinov M Misheva M Rodozov M Shopova G Sultanov A Dimitrov L Litov B Pavlov P Petkov W Fang X Gao L Yuan M Ahmad J G Bian G M Chen H S Chen M Chen Y Chen C H Jiang D Leggat H Liao Z Liu F Romeo S M Shaheen A Spiezia J Tao Z Wang E Yazgan H Zhang S Zhang J Zhao Y Ban G Chen A Levin J Li L Li Q Li Y Mao S J Qian D Wang Z Xu Y Wang C Avila A Cabrera C A Carrillo Montoya L F Chaparro Sierra C Florez C F González Hernández M A Segura Delgado B Courbon N Godinovic D Lelas I Puljak T Sculac Z Antunovic M Kovac V Brigljevic D Ferencek K Kadija B Mesic A Starodumov T Susa M W Ather A Attikis M Kolosova G Mavromanolakis J Mousa C Nicolaou F Ptochos P A Razis H Rykaczewski M Finger M Finger E Ayala E Carrera Jarrin H Abdalla A A Abdelalim E Salama S Bhowmik A Carvalho Antunes De Oliveira R K Dewanjee K Ehataht M Kadastik M Raidal C Veelken P Eerola H Kirschenmann J Pekkanen M Voutilainen J Havukainen J K Heikkilä T Järvinen V Karimäki R Kinnunen T Lampén K Lassila-Perini S Laurila S Lehti T Lindén P Luukka T Mäenpää H Siikonen E Tuominen J Tuominiemi T Tuuva M Besancon F Couderc M Dejardin D Denegri J L Faure F Ferri S Ganjour A Givernaud P Gras G Hamel de Monchenault P Jarry C Leloup E Locci J Malcles G Negro J Rander A Rosowsky M Ö Sahin M Titov A Abdulsalam C Amendola I Antropov F Beaudette P Busson C Charlot R Granier de Cassagnac I Kucher A Lobanov J Martin Blanco C Martin Perez M Nguyen C Ochando G Ortona P Paganini P Pigard J Rembser R Salerno J B Sauvan Y Sirois A G Stahl Leiton A Zabi A Zghiche J-L Agram J Andrea D Bloch J-M Brom E C Chabert V Cherepanov C Collard E Conte J-C Fontaine D Gelé U Goerlach M Jansová A-C Le Bihan N Tonon P Van Hove S Gadrat S Beauceron C Bernet G Boudoul N Chanon R Chierici D Contardo P Depasse H El Mamouni J Fay L Finco S Gascon M Gouzevitch G Grenier B Ille F Lagarde I B Laktineh H Lattaud M Lethuillier L Mirabito S Perries A Popov V Sordini G Touquet M Vander Donckt S Viret A Khvedelidze Z Tsamalaidze C Autermann L Feld M K Kiesel K Klein M Lipinski M Preuten M P Rauch C Schomakers J Schulz M Teroerde B Wittmer V Zhukov A Albert D Duchardt M Endres M Erdmann S Erdweg T Esch R Fischer S Ghosh A Güth T Hebbeker C Heidemann K Hoepfner H Keller L Mastrolorenzo M Merschmeyer A Meyer P Millet S Mukherjee T Pook M Radziej H Reithler M Rieger A Schmidt D Teyssier S Thüer G Flügge O Hlushchenko T Kress A Künsken T Müller A Nehrkorn A Nowack C Pistone O Pooth D Roy H Sert A Stahl M Aldaya Martin T Arndt C Asawatangtrakuldee I Babounikau K Beernaert O Behnke U Behrens A Bermúdez Martínez D Bertsche A A Bin Anuar K Borras V Botta A Campbell P Connor C Contreras-Campana V Danilov A De Wit M M Defranchis C Diez Pardos D Domínguez Damiani G Eckerlin T Eichhorn A Elwood E Eren E Gallo A Geiser A Grohsjean M Guthoff M Haranko A Harb J Hauk H Jung M Kasemann J Keaveney C Kleinwort J Knolle D Krücker W Lange A Lelek T Lenz J Leonard K Lipka W Lohmann R Mankel I-A Melzer-Pellmann A B Meyer M Meyer M Missiroli G Mittag J Mnich V Myronenko S K Pflitsch D Pitzl A Raspereza M Savitskyi P Saxena P Schütze C Schwanenberger R Shevchenko A Singh H Tholen O Turkot A Vagnerini G P Van Onsem R Walsh Y Wen K Wichmann C Wissing O Zenaiev R Aggleton S Bein L Benato A Benecke V Blobel T Dreyer E Garutti D Gonzalez P Gunnellini J Haller A Hinzmann A Karavdina G Kasieczka R Klanner R Kogler N Kovalchuk S Kurz V Kutzner J Lange D Marconi J Multhaup M Niedziela C E N Niemeyer D Nowatschin A Perieanu A Reimers O Rieger C Scharf P Schleper S Schumann J Schwandt J Sonneveld H Stadie G Steinbrück F M Stober M Stöver A Vanhoefer B Vormwald I Zoi M Akbiyik C Barth M Baselga S Baur E Butz R Caspart T Chwalek F Colombo W De Boer A Dierlamm K El Morabit N Faltermann B Freund M Giffels M A Harrendorf F Hartmann S M Heindl U Husemann F Kassel I Katkov S Kudella H Mildner S Mitra M U Mozer Th Müller M Plagge G Quast K Rabbertz M Schröder I Shvetsov G Sieber H J Simonis R Ulrich S Wayand M Weber T Weiler S Williamson C Wöhrmann R Wolf G Anagnostou G Daskalakis T Geralis A Kyriakis D Loukas G Paspalaki I Topsis-Giotis G Karathanasis S Kesisoglou P Kontaxakis A Panagiotou I Papavergou N Saoulidou E Tziaferi K Vellidis K Kousouris I Papakrivopoulos G Tsipolitis I Evangelou C Foudas P Gianneios P Katsoulis P Kokkas S Mallios N Manthos I Papadopoulos E Paradas J Strologas F A Triantis D Tsitsonis M Bartók M Csanad N Filipovic P Major M I Nagy G Pasztor O Surányi G I Veres G Bencze C Hajdu D Horvath Á Hunyadi F Sikler T Á Vámi V Veszpremi G Vesztergombi N Beni S Czellar J Karancsi A Makovec J Molnar Z Szillasi P Raics Z L Trocsanyi B Ujvari S Choudhury J R Komaragiri P C Tiwari S Bahinipati C Kar P Mal K Mandal A Nayak D K Sahoo S K Swain S Bansal S B Beri V Bhatnagar S Chauhan R Chawla N Dhingra R Gupta A Kaur M Kaur S Kaur R Kumar P Kumari M Lohan A Mehta K Sandeep S Sharma J B Singh A K Virdi G Walia A Bhardwaj B C Choudhary R B Garg M Gola S Keshri Ashok Kumar S Malhotra M Naimuddin P Priyanka K Ranjan Aashaq Shah R Sharma R Bhardwaj M Bharti R Bhattacharya S Bhattacharya U Bhawandeep D Bhowmik S Dey S Dutt S Dutta S Ghosh K Mondal S Nandan A Purohit P K Rout A Roy S Roy Chowdhury G Saha S Sarkar M Sharan B Singh S Thakur P K Behera R Chudasama D Dutta V Jha V Kumar P K Netrakanti L M Pant P Shukla T Aziz M A Bhat S Dugad G B Mohanty N Sur B Sutar Ravindra Kumar Verma S Banerjee S Bhattacharya S Chatterjee P Das M Guchait Sa Jain S Karmakar S Kumar M Maity G Majumder K Mazumdar N Sahoo T Sarkar S Chauhan S Dube V Hegde A Kapoor K Kothekar S Pandey A Rane S Sharma S Chenarani E Eskandari Tadavani S M Etesami M Khakzad M Mohammadi Najafabadi M Naseri F Rezaei Hosseinabadi B Safarzadeh M Zeinali M Felcini M Grunewald M Abbrescia C Calabria A Colaleo D Creanza L Cristella N De Filippis M De Palma A Di Florio F Errico L Fiore A Gelmi G Iaselli M Ince S Lezki G Maggi M Maggi G Miniello S My S Nuzzo A Pompili G Pugliese R Radogna A Ranieri G Selvaggi A Sharma L Silvestris R Venditti P Verwilligen G Zito G Abbiendi C Battilana D Bonacorsi L Borgonovi S Braibant-Giacomelli R Campanini P Capiluppi A Castro F R Cavallo S S Chhibra C Ciocca G Codispoti M Cuffiani G M Dallavalle F Fabbri A Fanfani E Fontanesi P Giacomelli C Grandi L Guiducci F Iemmi S Lo Meo S Marcellini G Masetti A Montanari F L Navarria A Perrotta F Primavera T Rovelli G P Siroli N Tosi S Albergo A Di Mattia R Potenza A Tricomi C Tuve G Barbagli K Chatterjee V Ciulli C Civinini R D'Alessandro E Focardi G Latino P Lenzi M Meschini S Paoletti L Russo G Sguazzoni D Strom L Viliani L Benussi S Bianco F Fabbri D Piccolo F Ferro F Ravera E Robutti S Tosi A Benaglia A Beschi L Brianza F Brivio V Ciriolo S Di Guida M E Dinardo S Fiorendi S Gennai A Ghezzi P Govoni M Malberti S Malvezzi A Massironi D Menasce F Monti L Moroni M Paganoni D Pedrini S Ragazzi T Tabarelli de Fatis D Zuolo S Buontempo N Cavallo A Di Crescenzo F Fabozzi F Fienga G Galati A O M Iorio W A Khan L Lista S Meola P Paolucci C Sciacca E Voevodina P Azzi N Bacchetta D Bisello A Boletti A Bragagnolo R Carlin P Checchia M Dall'Osso P De Castro Manzano T Dorigo U Dosselli F Gasparini U Gasparini A Gozzelino S Y Hoh S Lacaprara P Lujan M Margoni A T Meneguzzo J Pazzini P Ronchese R Rossin F Simonetto A Tiko E Torassa M Zanetti P Zotto G Zumerle A Braghieri A Magnani P Montagna S P Ratti V Re M Ressegotti C Riccardi P Salvini I Vai P Vitulo M Biasini G M Bilei C Cecchi D Ciangottini L Fanò P Lariccia R Leonardi E Manoni G Mantovani V Mariani M Menichelli A Rossi A Santocchia D Spiga K Androsov P Azzurri G Bagliesi L Bianchini T Boccali L Borrello R Castaldi M A Ciocci R Dell'Orso G Fedi F Fiori L Giannini A Giassi M T Grippo F Ligabue E Manca G Mandorli A Messineo F Palla A Rizzi P Spagnolo R Tenchini G Tonelli A Venturi P G Verdini L Barone F Cavallari M Cipriani D Del Re E Di Marco M Diemoz S Gelli E Longo B Marzocchi P Meridiani G Organtini F Pandolfi R Paramatti F Preiato S Rahatlou C Rovelli F Santanastasio N Amapane R Arcidiacono S Argiro M Arneodo N Bartosik R Bellan C Biino N Cartiglia F Cenna S Cometti M Costa R Covarelli N Demaria B Kiani C Mariotti S Maselli E Migliore V Monaco E Monteil M Monteno M M Obertino L Pacher N Pastrone M Pelliccioni G L Pinna Angioni A Romero M Ruspa R Sacchi K Shchelina V Sola A Solano D Soldi A Staiano S Belforte V Candelise M Casarsa F Cossutti A Da Rold G Della Ricca F Vazzoler A Zanetti D H Kim G N Kim M S Kim J Lee S Lee S W Lee C S Moon Y D Oh S I Pak S Sekmen D C Son Y C Yang H Kim D H Moon G Oh J Goh T J Kim S Cho S Choi Y Go D Gyun S Ha B Hong Y Jo K Lee K S Lee S Lee J Lim S K Park Y Roh H S Kim J Almond J Kim J S Kim H Lee K Lee K Nam S B Oh B C Radburn-Smith S H Seo U K Yang H D Yoo G B Yu D Jeon H Kim J H Kim J S H Lee I C Park Y Choi C Hwang J Lee I Yu V Dudenas A Juodagalvis J Vaitkus I Ahmed Z A Ibrahim M A B Md Ali F Mohamad Idris W A T Wan Abdullah M N Yusli Z Zolkapli J F Benitez A Castaneda Hernandez J A Murillo Quijada H Castilla-Valdez E De La Cruz-Burelo M C Duran-Osuna I Heredia-De La Cruz R Lopez-Fernandez J Mejia Guisao R I Rabadan-Trejo M Ramirez-Garcia G Ramirez-Sanchez R Reyes-Almanza A Sanchez-Hernandez S Carrillo Moreno C Oropeza Barrera F Vazquez Valencia J Eysermans I Pedraza H A Salazar Ibarguen C Uribe Estrada A Morelos Pineda D Krofcheck S Bheesette P H Butler A Ahmad M Ahmad M I Asghar Q Hassan H R Hoorani A Saddique M A Shah M Shoaib M Waqas H Bialkowska M Bluj B Boimska T Frueboes M Górski M Kazana M Szleper P Traczyk P Zalewski K Bunkowski A Byszuk K Doroba A Kalinowski M Konecki J Krolikowski M Misiura M Olszewski A Pyskir M Walczak M Araujo P Bargassa C Beirão Da Cruz E Silva A Di Francesco P Faccioli B Galinhas M Gallinaro J Hollar N Leonardo M V Nemallapudi J Seixas G Strong O Toldaiev D Vadruccio J Varela S Afanasiev P Bunin M Gavrilenko I Golutvin I Gorbunov A Kamenev V Karjavine A Lanev A Malakhov V Matveev P Moisenz V Palichik V Perelygin S Shmatov S Shulha N Skatchkov V Smirnov N Voytishin A Zarubin V Golovtsov Y Ivanov V Kim E Kuznetsova P Levchenko V Murzin V Oreshkin I Smirnov D Sosnov V Sulimov L Uvarov S Vavilov A Vorobyev Yu Andreev A Dermenev S Gninenko N Golubev A Karneyeu M Kirsanov N Krasnikov A Pashenkov D Tlisov A Toropin V Epshteyn V Gavrilov N Lychkovskaya V Popov I Pozdnyakov G Safronov A Spiridonov A Stepennov V Stolin M Toms E Vlasov A Zhokin T Aushev R Chistov M Danilov P Parygin D Philippov S Polikarpov E Tarkovskii V Andreev M Azarkin I Dremin M Kirakosyan S V Rusakov A Terkulov A Baskakov A Belyaev E Boos V Bunichev M Dubinin L Dudko V Klyukhin O Kodolova N Korneeva I Lokhtin I Miagkov S Obraztsov M Perfilov V Savrin P Volkov A Barnyakov V Blinov T Dimova L Kardapoltsev Y Skovpen I Azhgirey I Bayshev S Bitioukov D Elumakhov A Godizov V Kachanov A Kalinin D Konstantinov P Mandrik V Petrov R Ryutin S Slabospitskii A Sobol S Troshin N Tyurin A Uzunian A Volkov A Babaev S Baidali V Okhotnikov P Adzic P Cirkovic D Devetak M Dordevic J Milosevic J Alcaraz Maestre A Álvarez Fernández I Bachiller M Barrio Luna J A Brochero Cifuentes M Cerrada N Colino B De La Cruz A Delgado Peris C Fernandez Bedoya J P Fernández Ramos J Flix M C Fouz O Gonzalez Lopez S Goy Lopez J M Hernandez M I Josa D Moran A Pérez-Calero Yzquierdo J Puerta Pelayo I Redondo L Romero M S Soares A Triossi C Albajar J F de Trocóniz J Cuevas C Erice J Fernandez Menendez S Folgueras I Gonzalez Caballero J R González Fernández E Palencia Cortezon V Rodríguez Bouza S Sanchez Cruz P Vischia J M Vizan Garcia I J Cabrillo A Calderon B Chazin Quero J Duarte Campderros M Fernandez P J Fernández Manteca A García Alonso J Garcia-Ferrero G Gomez A Lopez Virto J Marco C Martinez Rivero P Martinez Ruiz Del Arbol F Matorras J Piedra Gomez C Prieels T Rodrigo A Ruiz-Jimeno L Scodellaro N Trevisani I Vila R Vilar Cortabitarte N Wickramage D Abbaneo B Akgun E Auffray G Auzinger P Baillon A H Ball D Barney J Bendavid M Bianco A Bocci C Botta E Brondolin T Camporesi M Cepeda G Cerminara E Chapon Y Chen G Cucciati D d'Enterria A Dabrowski N Daci V Daponte A David A De Roeck N Deelen M Dobson M Dünser N Dupont A Elliott-Peisert P Everaerts F Fallavollita D Fasanella G Franzoni J Fulcher W Funk D Gigi A Gilbert K Gill F Glege M Guilbaud D Gulhan J Hegeman C Heidegger V Innocente A Jafari P Janot O Karacheban J Kieseler A Kornmayer M Krammer C Lange P Lecoq C Lourenço L Malgeri M Mannelli F Meijers J A Merlin S Mersi E Meschi P Milenovic F Moortgat M Mulders J Ngadiuba S Nourbakhsh S Orfanelli L Orsini F Pantaleo L Pape E Perez M Peruzzi A Petrilli G Petrucciani A Pfeiffer M Pierini F M Pitters D Rabady A Racz T Reis G Rolandi M Rovere H Sakulin C Schäfer C Schwick M Seidel M Selvaggi A Sharma P Silva P Sphicas A Stakia J Steggemann M Tosi D Treille A Tsirou V Veckalns M Verzetti W D Zeuner L Caminada K Deiters W Erdmann R Horisberger Q Ingram H C Kaestli D Kotlinski U Langenegger T Rohe S A Wiederkehr M Backhaus L Bäni P Berger N Chernyavskaya G Dissertori M Dittmar M Donegà C Dorfer T A Gómez Espinosa C Grab D Hits T Klijnsma W Lustermann R A Manzoni M Marionneau M T Meinhard F Micheli P Musella F Nessi-Tedaldi J Pata F Pauss G Perrin L Perrozzi S Pigazzini M Quittnat C Reissel D Ruini D A Sanz Becerra M Schönenberger L Shchutska V R Tavolaro K Theofilatos M L Vesterbacka Olsson R Wallny D H Zhu T K Aarrestad C Amsler D Brzhechko M F Canelli A De Cosa R Del Burgo S Donato C Galloni T Hreus B Kilminster S Leontsinis I Neutelings D Pinna G Rauco P Robmann D Salerno K Schweiger C Seitz Y Takahashi A Zucchetta Y H Chang K Y Cheng T H Doan R Khurana C M Kuo W Lin A Pozdnyakov S S Yu P Chang Y Chao K F Chen P H Chen W-S Hou Arun Kumar Y F Liu R-S Lu E Paganis A Psallidas A Steen B Asavapibhop N Srimanobhas N Suwonjandee A Bat F Boran S Cerci S Damarseckin Z S Demiroglu F Dolek C Dozen I Dumanoglu S Girgis G Gokbulut Y Guler E Gurpinar I Hos C Isik E E Kangal O Kara A Kayis Topaksu U Kiminsu M Oglakci G Onengut K Ozdemir S Ozturk D Sunar Cerci B Tali U G Tok S Turkcapar I S Zorbakir C Zorbilmez B Isildak G Karapinar M Yalvac M Zeyrek I O Atakisi E Gülmez M Kaya O Kaya S Ozkorucuklu S Tekten E A Yetkin M N Agaras A Cakir K Cankocak Y Komurcu S Sen B Grynyov L Levchuk F Ball L Beck J J Brooke D Burns E Clement D Cussans O Davignon H Flacher J Goldstein G P Heath H F Heath L Kreczko D M Newbold S Paramesvaran B Penning T Sakuma D Smith V J Smith J Taylor A Titterton K W Bell A Belyaev C Brew R M Brown D Cieri D J A Cockerill J A Coughlan K Harder S Harper J Linacre E Olaiya D Petyt C H Shepherd-Themistocleous A Thea I R Tomalin T Williams W J Womersley R Bainbridge P Bloch J Borg S Breeze O Buchmuller A Bundock D Colling P Dauncey G Davies M Della Negra R Di Maria Y Haddad G Hall G Iles T James M Komm C Laner L Lyons A-M Magnan S Malik A Martelli J Nash A Nikitenko V Palladino M Pesaresi D M Raymond A Richards A Rose E Scott C Seez A Shtipliyski G Singh M Stoye T Strebler S Summers A Tapper K Uchida T Virdee N Wardle D Winterbottom J Wright S C Zenz J E Cole P R Hobson A Khan P Kyberd C K Mackay A Morton I D Reid L Teodorescu S Zahid K Call J Dittmann K Hatakeyama H Liu C Madrid B Mcmaster N Pastika C Smith R Bartek A Dominguez A Buccilli S I Cooper C Henderson P Rumerio C West D Arcaro T Bose D Gastler D Rankin C Richardson J Rohlf L Sulak D Zou G Benelli X Coubez D Cutts M Hadley J Hakala U Heintz J M Hogan K H M Kwok E Laird G Landsberg J Lee Z Mao M Narain S Sagir R Syarif E Usai D Yu R Band C Brainerd R Breedon D Burns M Calderon De La Barca Sanchez M Chertok J Conway R Conway P T Cox R Erbacher C Flores G Funk W Ko O Kukral R Lander M Mulhearn D Pellett J Pilot S Shalhout M Shi D Stolp D Taylor K Tos M Tripathi Z Wang F Zhang M Bachtis C Bravo R Cousins A Dasgupta A Florent J Hauser M Ignatenko N Mccoll S Regnard D Saltzberg C Schnaible V Valuev E Bouvier K Burt R Clare J W Gary S M A Ghiasi Shirazi G Hanson G Karapostoli E Kennedy F Lacroix O R Long M Olmedo Negrete M I Paneva W Si L Wang H Wei S Wimpenny B R Yates J G Branson P Chang S Cittolin M Derdzinski R Gerosa D Gilbert B Hashemi A Holzner D Klein G Kole V Krutelyov J Letts M Masciovecchio D Olivito S Padhi M Pieri M Sani V Sharma S Simon M Tadel A Vartak S Wasserbaech J Wood F Würthwein A Yagil G Zevi Della Porta N Amin R Bhandari J Bradmiller-Feld C Campagnari M Citron A Dishaw V Dutta M Franco Sevilla L Gouskos R Heller J Incandela A Ovcharova H Qu J Richman D Stuart I Suarez S Wang J Yoo D Anderson A Bornheim J M Lawhorn H B Newman T Q Nguyen M Spiropulu J R Vlimant R Wilkinson S Xie Z Zhang R Y Zhu M B Andrews T Ferguson T Mudholkar M Paulini M Sun I Vorobiev M Weinberg J P Cumalat W T Ford F Jensen A Johnson M Krohn E MacDonald T Mulholland R Patel K Stenson K A Ulmer S R Wagner J Alexander J Chaves Y Cheng J Chu A Datta K Mcdermott N Mirman J R Patterson D Quach A Rinkevicius A Ryd L Skinnari L Soffi S M Tan Z Tao J Thom J Tucker P Wittich M Zientek S Abdullin M Albrow M Alyari G Apollinari A Apresyan A Apyan S Banerjee L A T Bauerdick A Beretvas J Berryhill P C Bhat G Bolla K Burkett J N Butler A Canepa G B Cerati H W K Cheung F Chlebana M Cremonesi J Duarte V D Elvira J Freeman Z Gecse E Gottschalk L Gray D Green S Grünendahl O Gutsche J Hanlon R M Harris S Hasegawa J Hirschauer Z Hu B Jayatilaka S Jindariani M Johnson U Joshi B Klima M J Kortelainen B Kreis S Lammel D Lincoln R Lipton M Liu T Liu J Lykken K Maeshima J M Marraffino D Mason P McBride P Merkel S Mrenna S Nahn V O'Dell K Pedro C Pena O Prokofyev G Rakness L Ristori A Savoy-Navarro B Schneider E Sexton-Kennedy A Soha W J Spalding L Spiegel S Stoynev J Strait N Strobbe L Taylor S Tkaczyk N V Tran L Uplegger E W Vaandering C Vernieri M Verzocchi R Vidal M Wang H A Weber A Whitbeck D Acosta P Avery P Bortignon D Bourilkov A Brinkerhoff L Cadamuro A Carnes M Carver D Curry R D Field S V Gleyzer B M Joshi J Konigsberg A Korytov K H Lo P Ma K Matchev H Mei G Mitselmakher D Rosenzweig K Shi D Sperka J Wang S Wang X Zuo Y R Joshi S Linn A Ackert T Adams A Askew S Hagopian V Hagopian K F Johnson T Kolberg G Martinez T Perry H Prosper A Saha C Schiber R Yohay M M Baarmand V Bhopatkar S Colafranceschi M Hohlmann D Noonan M Rahmani T Roy F Yumiceva M R Adams L Apanasevich D Berry R R Betts R Cavanaugh X Chen S Dittmer O Evdokimov C E Gerber D A Hangal D J Hofman K Jung J Kamin C Mills I D Sandoval Gonzalez M B Tonjes H Trauger N Varelas H Wang X Wang Z Wu J Zhang M Alhusseini B Bilki W Clarida K Dilsiz S Durgut R P Gandrajula M Haytmyradov V Khristenko J-P Merlo A Mestvirishvili A Moeller J Nachtman H Ogul Y Onel F Ozok A Penzo C Snyder E Tiras J Wetzel B Blumenfeld A Cocoros N Eminizer D Fehling L Feng A V Gritsan W T Hung P Maksimovic J Roskes U Sarica M Swartz M Xiao C You A Al-Bataineh P Baringer A Bean S Boren J Bowen A Bylinkin J Castle S Khalil A Kropivnitskaya D Majumder W Mcbrayer M Murray C Rogan S Sanders E Schmitz J D Tapia Takaki Q Wang S Duric A Ivanov K Kaadze D Kim Y Maravin D R Mendis T Mitchell A Modak A Mohammadi L K Saini N Skhirtladze F Rebassoo D Wright A Baden O Baron A Belloni S C Eno Y Feng C Ferraioli N J Hadley S Jabeen G Y Jeng R G Kellogg J Kunkle A C Mignerey S Nabili F Ricci-Tam Y H Shin A Skuja S C Tonwar K Wong D Abercrombie B Allen V Azzolini A Baty G Bauer R Bi S Brandt W Busza I A Cali M D'Alfonso Z Demiragli G Gomez Ceballos M Goncharov P Harris D Hsu M Hu Y Iiyama G M Innocenti M Klute D Kovalskyi Y-J Lee P D Luckey B Maier A C Marini C Mcginn C Mironov S Narayanan X Niu C Paus C Roland G Roland G S F Stephans K Sumorok K Tatar D Velicanu J Wang T W Wang B Wyslouch S Zhaozhong A C Benvenuti R M Chatterjee A Evans P Hansen Sh Jain S Kalafut Y Kubota Z Lesko J Mans N Ruckstuhl R Rusack J Turkewitz M A Wadud J G Acosta S Oliveros E Avdeeva K Bloom D R Claes C Fangmeier F Golf R Gonzalez Suarez R Kamalieddin I Kravchenko J Monroy J E Siado G R Snow B Stieger A Godshalk C Harrington I Iashvili A Kharchilava C Mclean D Nguyen A Parker S Rappoccio B Roozbahani G Alverson E Barberis C Freer A Hortiangtham D M Morse T Orimoto R Teixeira De Lima T Wamorkar B Wang A Wisecarver D Wood S Bhattacharya O Charaf K A Hahn N Mucia N Odell M H Schmitt K Sung M Trovato M Velasco R Bucci N Dev M Hildreth K Hurtado Anampa C Jessop D J Karmgard N Kellams K Lannon W Li N Loukas N Marinelli F Meng C Mueller Y Musienko M Planer A Reinsvold R Ruchti P Siddireddy G Smith S Taroni M Wayne A Wightman M Wolf A Woodard J Alimena L Antonelli B Bylsma L S Durkin S Flowers B Francis A Hart C Hill W Ji T Y Ling W Luo B L Winer S Cooperstein P Elmer J Hardenbrook S Higginbotham A Kalogeropoulos D Lange M T Lucchini J Luo D Marlow K Mei I Ojalvo J Olsen C Palmer P Piroué J Salfeld-Nebgen D Stickland C Tully S Malik S Norberg A Barker V E Barnes S Das L Gutay M Jones A W Jung A Khatiwada B Mahakud D H Miller N Neumeister C C Peng S Piperov H Qiu J F Schulte J Sun F Wang R Xiao W Xie T Cheng J Dolen N Parashar Z Chen K M Ecklund S Freed F J M Geurts M Kilpatrick W Li B P Padley R Redjimi J Roberts J Rorie W Shi Z Tu J Zabel A Zhang A Bodek P de Barbaro R Demina Y T Duh J L Dulemba C Fallon T Ferbel M Galanti A Garcia-Bellido J Han O Hindrichs A Khukhunaishvili P Tan R Taus A Agapitos J P Chou Y Gershtein E Halkiadakis M Heindl E Hughes S Kaplan R Kunnawalkam Elayavalli S Kyriacou A Lath R Montalvo K Nash M Osherson H Saka S Salur S Schnetzer D Sheffield S Somalwar R Stone S Thomas P Thomassen M Walker A G Delannoy J Heideman G Riley S Spanier O Bouhali A Celik M Dalchenko M De Mattia A Delgado S Dildick R Eusebi J Gilmore T Huang T Kamon S Luo R Mueller A Perloff L Perniè D Rathjens A Safonov N Akchurin J Damgov F De Guio P R Dudero S Kunori K Lamichhane S W Lee T Mengke S Muthumuni T Peltola S Undleeb I Volobouev Z Wang S Greene A Gurrola R Janjam W Johns C Maguire A Melo H Ni K Padeken J D Ruiz Alvarez P Sheldon S Tuo J Velkovska M Verweij Q Xu M W Arenton P Barria B Cox R Hirosky M Joyce A Ledovskoy H Li C Neu T Sinthuprasith Y Wang E Wolfe F Xia R Harr P E Karchin N Poudyal J Sturdy P Thapa S Zaleski M Brodski J Buchanan C Caillol D Carlsmith S Dasu L Dodd B Gomber M Grothe M Herndon A Hervé U Hussain P Klabbers A Lanaro K Long R Loveless T Ruggles A Savin V Sharma N Smith W H Smith N Woods

Phys Rev Lett 2018 Nov;121(22):221802

University of Wisconsin, Madison, Wisconsin, USA.

The first evidence of events consistent with the production of a single top quark in association with a photon is reported. The analysis is based on proton-proton collisions at sqrt[s]=13  TeV and recorded by the CMS experiment in 2016, corresponding to an integrated luminosity of 35.9  fb^{-1}. Read More

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November 2018
7.512 Impact Factor

Bronchiolitis Obliterans without Joint Disease. A rare non-articular manifestation of Rheumatoid Arthritis

Ir Med J 2018 09 10;111(8):813. Epub 2018 Sep 10.

Department of Respiratory Medicine, Cork University Hospital, Cork, Ireland

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September 2018

Examination of the Structure and Measurement of Inattentive, Hyperactive, and Impulsive Behaviors from Preschool to Grade 4.

J Abnorm Child Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, Florida State University, 1107 W. Call Street, Tallahassee, FL, 32306-4301, USA.

Attention Deficit/Hyperactivity Disorder (ADHD) is a complex and heterogeneous disorder consisting of inattentive and hyperactive/impulsive behaviors. Although, the multidimensionality of ADHD is widely accepted, questions remain regarding the extent to which the components of this disorder are overlapping or distinct. Further, although the same measures are generally used to assess inattentive, hyperactive, and impulsive behaviors across childhood, it has been argued that the structure and measurement of inattentive, hyperactive, and impulsive behaviors may be susceptible to developmental influences. Read More

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December 2018

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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December 2018
1 Read

Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes.

PLoS One 2018 13;13(12):e0208829. Epub 2018 Dec 13.

Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.

Mitochondrial DNA (mtDNA) haplogroups (hgs) are evolutionarily conserved sets of mtDNA SNP-haplotypes with characteristic geographical distribution. Associations of hgs with disease and physiological characteristics have been reported, but have frequently not been reproducible. Using 418 mtDNA SNPs on the PsychChip (Illumina), we assessed the spatio-temporal distribution of mtDNA hgs in Denmark from DNA isolated from 24,642 geographically un-biased dried blood spots (DBS), collected from 1981 to 2005 through the Danish National Neonatal Screening program. Read More

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December 2018

Trends in the Mode of Delivery of Pregnant Women in Rural Guatemala from a Quality Improvement Database.

Matern Child Health J 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA.

Purpose To evaluate trends and factors associated with mode of delivery in the rural Southwest Trifinio region of Guatemala. Description We conducted a retrospective analysis of self-reported antepartum factors and postpartum outcomes recorded in a quality improvement database among 430 women enrolled in a home-based maternal healthcare program between June 1, 2015 and August 1, 2017. Assessment Over the study period, the rates of cesarean delivery (CD) increased (from 30 to 45%) and rates of vaginal delivery (VD) decreased (70-55%) while facility-based delivery attendance remained stable around 70%. Read More

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December 2018

Structure-function relationships of donor-acceptor Stenhouse adduct photochromic switches.

Chem Sci 2018 Nov 12;9(43):8242-8252. Epub 2018 Sep 12.

School of Chemistry , UNSW Sydney , High St, Kensington , Sydney , NSW , Australia . Email:

The first in-depth, systematic study of the photoswitching properties of Donor-Acceptor Stenhouse Adducts (DASAs) is reported. Barbituric acid derived DASAs functionalised with 14 different amines ranging from dimethylamine to 4-methoxy--methylaniline were structurally characterised in solution using H and C NMR spectroscopy and, in eight cases, in the solid state by single crystal X-ray diffraction. The distribution of coloured and colourless isomers in the dark, their photostationary states under irradiation, apparent thermal half-lives, and fatigue resistance are systematically compared. Read More

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November 2018
1 Read

Anterolateral Complex Reconstruction: Another Fad or Method to Improve ACL Outcomes?

Tech Orthop 2018 Dec 25;33(4):239-245. Epub 2017 Dec 25.

The Fowler Kennedy Sport Medicine Clinic.

Anterolateral rotational laxity of the knee is a persistent problem following anterior cruciate ligament reconstruction (ACLR) that can lead to increased rates of graft failure. Renewed interest in the anterolateral complex of the knee has led to a resurgence in the use of adjunctive techniques such as lateral extra-articular tenodesis and anterolateral ligament reconstruction. Use of these techniques can restore normal knee kinematics and potentially thereby reduce the rate of graft failure. Read More

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December 2018

An Overview of Clinically Relevant Biomechanics of the Anterolateral Structures of the Knee.

Tech Orthop 2018 Dec 25;33(4):213-218. Epub 2017 Dec 25.

Steadman Philippon Research Institute.

Residual anterolateral rotatory laxity following injury and reconstruction of the anterior cruciate ligament (ACL) has become a popular topic and has generated interest in characterizing the relative contribution from the anterolateral structures of the knee. Studies have reported on the anatomic and biomechanical features of the anterolateral ligament (ALL), revealing a role in restraining internal tibial rotation in both ACL-intact and ACL-deficient knees. The Kaplan fibers of the iliotibial band have also been reported to provide significant restraint to internal tibial rotation. Read More

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December 2018

The Anterolateral Complex: More than Just One Ligament ….

Authors:
Alan Getgood

Tech Orthop 2018 Dec 25;33(4):205. Epub 2017 Dec 25.

Fowler Kennedy Sports Medicine Clinic/Department of Surgery, Western University, London ON, Canada.

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December 2018

Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.

Proc Natl Acad Sci U S A 2018 Dec 12. Epub 2018 Dec 12.

Génétique Reproduction & Développement, CNRS UMR 6293, Inserm U1103, Université Clermont Auvergne, 63001 Clermont-Ferrand, France;

Adrenal cortex steroids are essential for body homeostasis, and adrenal insufficiency is a life-threatening condition. Adrenal endocrine activity is maintained through recruitment of subcapsular progenitor cells that follow a unidirectional differentiation path from zona glomerulosa to zona fasciculata (zF). Here, we show that this unidirectionality is ensured by the histone methyltransferase EZH2. Read More

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December 2018

Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain.

Sci Transl Med 2018 Dec;10(471)

Division of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD 21287, USA.

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant. One of the most important long-term complications observed in children who survive NEC early in life is the development of profound neurological impairments. However, the pathways leading to NEC-associated neurological impairments remain unknown, thus limiting the development of prevention strategies. Read More

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December 2018
15.843 Impact Factor

Transposable element insertions in fission yeast drive adaptation to environmental stress.

Genome Res 2018 Dec 12. Epub 2018 Dec 12.

Section on Eukaryotic Transposable Elements, Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

Cells are regularly exposed to a range of naturally occurring stress that can restrict growth or cause lethality. In response, cells activate expression networks with hundreds of genes that together increase resistance to common environmental insults. However, stress response networks can be insufficient to ensure survival, which raises the question of whether cells possess genetic programs that can promote adaptation to novel forms of stress. Read More

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December 2018

Re-comparing of three different epidemic seasons of bronchiolitis: different prophylaxis approaches.

Ital J Pediatr 2018 Dec 12;44(1):148. Epub 2018 Dec 12.

Neonatology-NICU Casilino General Hospital, via Casilina 1049, 00169, Rome, Italy.

During the last epidemic season of bronchiolitis (S2, years 2016-2017) we performed a single Centre analysis in inborn infant of 30-32 gestational age and age < 12 months who did not receive prophylaxis with palivizumab (PLV), in light of the current AIFA (Italian Drug Agency) guidelines restricting the time of the prophylaxis to those born < 30 weeks of gestational age. During that epidemic season, we observed a rising trend of bronchiolitis-related hospitalization and an increased rate of mechanical ventilation in preterm child compared to the previous one (S1, years 2015-2016) during which infants of this same gestational age received palivizumab (PLV) prophylaxis, according to the 2015 Italian Guidelines.In light of the revised AIFA guidelines (November 2017), allowing once again prophylaxis with PLV in infants of > 30 weeks gestational age, we decided to repeat our observation during the last epidemic season (S3, years 2017-2018), in order to compare ours infants of 30-32 gestational age with preterm of the same gestational age born in our unit in the previous seasons (S1 and S2), to evaluate the clinical impact of the different prophylaxis approaches. Read More

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December 2018

Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate.

Genome Biol 2018 Dec 13;19(1):216. Epub 2018 Dec 13.

Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA.

Background: The organization of chromatin in the nucleus plays an essential role in gene regulation. About half of the mammalian genome comprises transposable elements. Given their repetitive nature, reads associated with these elements are generally discarded or randomly distributed among elements of the same type in genome-wide analyses. Read More

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December 2018

Rationale, design, and methods for the Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD) study.

BMC Pregnancy Childbirth 2018 Dec 12;18(1):488. Epub 2018 Dec 12.

The University of North Carolina at Chapel Hill School of Medicine, Campus Box 7516, Chapel Hill, NC, 27599-7516, USA.

Background: Annually in the US, over 100,000 pregnant women with overt type 2 diabetes give birth. Strict maternal glycemic control is the key to optimizing infant outcomes. Medical treatment of type 2 diabetes in pregnancy is generally restricted to insulin, as data on the safety and efficacy of oral hypoglycemic agents in pregnancy are limited. Read More

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December 2018

Statistical learning as a window into developmental disabilities.

Authors:
Jenny R Saffran

J Neurodev Disord 2018 Dec 13;10(1):35. Epub 2018 Dec 13.

Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI, 53705, USA.

Until recently, most behavioral studies of children with intellectual and developmental disabilities (IDD) have used standardized assessments as a means to probe etiology and to characterize phenotypes. Over the past decade, however, tasks originally developed to investigate learning processes in typical development have been brought to bear on developmental processes in children with IDD.This brief review will focus on one learning process in particular-statistical learning-and will provide an overview of what has been learned thus far from studies using statistical learning tasks with different groups of children with IDD conditions. Read More

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December 2018

ADHD-related sex differences in fronto-subcortical intrinsic functional connectivity and associations with delay discounting.

J Neurodev Disord 2018 Dec 13;10(1):34. Epub 2018 Dec 13.

Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, 21205, USA.

Background: Attention-deficit/hyperactivity disorder (ADHD) is associated with atypical fronto-subcortical neural circuitry and heightened delay discounting, or a stronger preference for smaller, immediate rewards over larger, delayed rewards. Recent evidence of ADHD-related sex differences in brain structure and function suggests anomalies in fronto-subcortical circuitry may differ among girls and boys with ADHD. The current study examined whether the functional connectivity (FC) within fronto-subcortical neural circuitry differs among girls and boys with ADHD compared to same-sex typically developing (TD) controls and relates to delay discounting. Read More

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December 2018

Cerebrospinal fluid and the early brain development of autism.

Authors:
Mark D Shen

J Neurodev Disord 2018 Dec 13;10(1):39. Epub 2018 Dec 13.

Carolina Institute for Developmental Disabilities, Department of Psychiatry, and the UNC Intellectual and Developmental Disabilities Research Center, University of North Carolina at Chapel Hill School of Medicine, Campus Box 3367, Chapel Hill, NC, 27599-3367, USA.

Background: There is currently a renaissance of interest in the many functions of cerebrospinal fluid (CSF). Altered flow of CSF, for example, has been shown to impair the clearance of pathogenic inflammatory proteins involved in neurodegenerative diseases, such as amyloid-β. In addition, the role of CSF in the newly discovered lymphatic system of the brain has become a prominently researched area in clinical neuroscience, as CSF serves as a conduit between the central nervous system and immune system. Read More

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December 2018

Xq26.3 Duplication in a Boy With Motor Delay and Low Muscle Tone Refines the X-Linked Acrogigantism Genetic Locus.

J Endocr Soc 2018 Oct 3;2(10):1100-1108. Epub 2018 Aug 3.

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland.

We describe a 4-year-old boy with developmental delay who was found to carry by clinical grade (CG) molecular cytogenetics (MCs) a chromosome Xq26 microduplication. The report prompted a referral of the patient for possible X-linked acrogigantism (X-LAG), a well-defined condition (MIM300942) due to chromosomal microduplication of a nearby region. The patient was evaluated clinically and investigated for endocrine abnormalities related to X-LAG and not only did he not have acrogigantism, but his growth parameters and other hormones were all normal. Read More

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October 2018

Adoptive cell therapy with tumor-infiltrating lymphocytes in patients with metastatic ovarian cancer: a pilot study.

Oncoimmunology 2018 26;7(12):e1502905. Epub 2018 Sep 26.

Center for Cancer Immune Therapy, Department of Hematology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.

:Ovarian cancer (OC) is often diagnosed at an advanced stage with two thirds of patients experiencing recurrent disease with a poor prognosis. Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) has shown curative potential in malignant melanoma, but has only been investigated scarcely in other cancers. In this pilot study, we tested TIL based ACT in patients with metastatic OC. Read More

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September 2018

Striving to Make Massage Therapy Accessible to Older Adults: an Interview with Niki Munk, PhD, LMT.

Int J Ther Massage Bodywork 2018 Dec 1;11(4):1-3. Epub 2018 Dec 1.

Department of Biomedical Sciences, Division of Behavioral, Social, and Population Health, University of South Carolina School of Medicine Greenville, Greenville, SC, USA.

First she became a licensed massage therapist in Kentucky. Then, in a quest to improve the care she provided to her elderly clinical population, Niki Munk continued her journey by furthering her education and receiving her doctorate in gerontology. Dr. Read More

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December 2018

Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy.

J Clin Oncol 2018 Dec 3:JCO1801314. Epub 2018 Dec 3.

1 University of Leeds, Leeds, United Kingdom.

Purpose: Biologic heterogeneity is a feature of diffuse large B-cell lymphoma (DLBCL), and the existence of a subgroup with poor prognosis and phenotypic proximity to Burkitt lymphoma is well known. Conventional cytogenetics identifies some patients with rearrangements of MYC and BCL2 and/or BCL6 (double-hit lymphomas) who are increasingly treated with more intensive chemotherapy, but a more biologically coherent and clinically useful definition of this group is required.

Patients And Methods: We defined a molecular high-grade (MHG) group by applying a gene expression-based classifier to 928 patients with DLBCL from a clinical trial that investigated the addition of bortezomib to standard rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy. Read More

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December 2018

A population-based examination of maltreatment referrals and substantiation for children with autism spectrum disorder.

Autism 2018 Dec 7:1362361318813998. Epub 2018 Dec 7.

3 Vanderbilt Kennedy Center, USA.

Children with disabilities experience elevated rates of maltreatment, but little is known about the interaction of children with autism spectrum disorder with child protection systems. A population-based dataset of 24,306 children born in 2008 in Tennessee, which included 387 children with autism spectrum disorder identified through the Autism and Developmental Disabilities Monitoring network, was linked with state child protection records. Rates of maltreatment referrals, screening for further action, and substantiated maltreatment were examined for children with versus without autism spectrum disorder. Read More

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December 2018

Improving Quality, Reproducibility, and Usability of FRET-Based Tension Sensors.

Cytometry A 2018 Dec 6. Epub 2018 Dec 6.

Department of Biomedical Engineering, Duke University, Durham, North Carolina, 27708.

Mechanobiology, the study of how mechanical forces affect cellular behavior, is an emerging field of study that has garnered broad and significant interest. Researchers are currently seeking to better understand how mechanical signals are transmitted, detected, and integrated at a subcellular level. One tool for addressing these questions is a Förster resonance energy transfer (FRET)-based tension sensor, which enables the measurement of molecular-scale forces across proteins based on changes in emitted light. Read More

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December 2018

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.

EMBO J 2018 Dec 6. Epub 2018 Dec 6.

Peninsula Dental School, University of Plymouth, Plymouth, UK

Proper temporal and spatial activation of stem cells relies on highly coordinated cell signaling. The primary cilium is the sensory organelle that is responsible for transmitting extracellular signals into a cell. Primary cilium size, architecture, and assembly-disassembly dynamics are under rigid cell cycle-dependent control. Read More

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December 2018

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).

Bioorg Med Chem 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacy, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy. Electronic address:

Collagen degradation and proMMP-2 activation are major functions of MT1-MMP to promote cancer cell invasion. Since both processes require MT1-MMP homodimerization on the cell surface, herein we propose that the use of bifunctional inhibitors of this enzyme could represent an innovative approach to efficiently reduce tumor growth. A small series of symmetrical dimers derived from previously described monomeric arylsulfonamide hydroxamates was synthesized and tested in vitro on isolated MMPs. Read More

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November 2018

Adequate evidence to support improved outcomes in depression by primary care physicians compared to psychiatrists when using combinatorial pharmacogenomics.

J Psychiatr Res 2018 Nov 15. Epub 2018 Nov 15.

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. Electronic address:

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November 2018

30-Day Readmissions After Endovascular Thrombectomy for Acute Ischemic Stroke.

JACC Cardiovasc Interv 2018 Dec;11(23):2414-2424

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

Objectives: The authors sought to investigate the incidence, predictors, and causes of 30-day nonelective readmissions after endovascular thrombectomy (EVT).

Background: Randomized trials have demonstrated that EVT improves outcomes in patients with acute ischemic stroke.

Methods: The Nationwide Readmissions Database, years 2013 and 2014, was used to identify hospitalizations for a primary diagnosis of acute ischemic stroke during which patients underwent EVT, with or without intravenous thrombolysis. Read More

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December 2018

Short- and long-term reproducibility of diffusion-weighted magnetic resonance imaging of lower extremity musculature in asymptomatic individuals and a comparison to individuals with spinal cord injury.

BMC Musculoskelet Disord 2018 Dec 6;19(1):433. Epub 2018 Dec 6.

Department of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Diffusion-weighted magnetic resonance imaging (DW-MRI) of skeletal muscle has the potential to be a sensitive diagnostic and/or prognostic tool in complex, enigmatic neuromusculoskeletal conditions such as spinal cord injury and whiplash associated disorder. However, the reliability and reproducibility of clinically accessible DW-MRI parameters in skeletal muscle remains incompletely characterized - even in individuals without neuromusculoskeletal injury - and these parameters have yet to be characterized for many clinical populations. Here, we provide normative measures of the apparent diffusion coefficient (ADC) in healthy muscles of the lower limb; assess the rater-based reliability and short- and long-term reproducibility of the ADC in the same muscles; and quantify ADC of these muscles in individuals with motor incomplete spinal cord injury. Read More

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December 2018

Roles of Ventromedial Prefrontal Cortex and Anterior Cingulate in Subjective Valuation of Prospective Effort.

Cereb Cortex 2018 Dec 12. Epub 2018 Dec 12.

Department of Biomedical Engineering, Johns Hopkins School of Medicine, 773 North Broadway, Baltimore, MD, USA.

The perceived effort level of an action shapes everyday decisions. Despite the importance of these perceptions for decision-making, the behavioral and neural representations of the subjective cost of effort are not well understood. While a number of studies have implicated anterior cingulate cortex (ACC) in decisions about effort/reward trade-offs, none have experimentally isolated effort valuation from reward and choice difficulty, a function that is commonly ascribed to this region. Read More

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December 2018