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    889 results match your criteria Keloid and Hypertrophic Scar

    1 OF 18

    Inhibition of IRE1 Results in Decreased Scar Formation.
    Wound Repair Regen 2018 Jan 8. Epub 2018 Jan 8.
    Department of Surgery, Stanford University School of Medicine, Stanford, California.
    Wound healing is characterized by the production of large amounts of protein necessary to replace lost cellular mass and extracellular matrix. The unfolded protein response (UPR) is an important adaptive cellular response to increased protein synthesis. One of the main components of the UPR is IRE1, an ER transmembrane protein with endonuclease activity that produces the activated form of the transcription factor XBP1. Read More

    Comparison of the effectiveness of topical silicone gel and corticosteroid cream on the pfannenstiel scar prevention - a randomized controlled trial.
    Ginekol Pol 2017 ;88(11):591-598
    Acıbadem Kozyatagı Hospital, Department of Obstetrics and Gynecology, Inonu Caddesi, Okur Sokak, No:20 Kozyatagı, 34742 Istanbul, Turkey.
    Objectives: To compare the effects of topical silicone gel and corticosteroid cream for preventing hypertrophic scar and keloid formation following Pfannenstiel incisions.

    Material And Methods: Fifty patients operated for benign gynecological diseases through primary Pfannenstiel incision were included. The wounds were randomly allocated to the treatment and control arms. Read More

    High-Mobility Group Box 1 Mediates Fibroblast Activity via RAGE-MAPK and NF-κB Signaling in Keloid Scar Formation.
    Int J Mol Sci 2017 Dec 28;19(1). Epub 2017 Dec 28.
    Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul 03722, Korea.
    Emerging studies have revealed the involvement of high-mobility group box 1 (HMGB1) in systemic fibrotic diseases, yet its role in the cutaneous scarring process has not yet been investigated. We hypothesized that HMGB1 may promote fibroblast activity to cause abnormal cutaneous scarring. In vitro wound healing assay with normal and keloid fibroblasts demonstrated that HMGB1 administration promoted the migration of both fibroblasts with increased speed and a greater traveling distance. Read More

    Techniques for Optimizing Surgical Scars, Part 2: Hypertrophic Scars and Keloids.
    Skinmed 2017 1;15(6):451-456. Epub 2017 Dec 1.
    Refresh Dermatology, Houston, TX;
    Surgical management of benign or malignant cutaneous tumors may result in noticeable scars that are of great concern to patients, regardless of sex, age, or ethnicity. Techniques to optimize surgical scars are discussed in this three-part review. Part 2 focuses on scar revision for hypertrophic and keloids scars. Read More

    Identification of the potential targets for keloid and hypertrophic scar prevention.
    J Dermatolog Treat 2018 Jan 10:1-6. Epub 2018 Jan 10.
    b Department of Thyroid Surgery , China-Japan Union Hospital of Jilin University , Changchun , China.
    Purpose: We aimed to explore the molecular mechanism of pathologic skin scar and novel target for scar prevention.

    Materials And Methods: Microarray data derived from keloid and hypertrophic scar were downloaded from ArrayExpress database. The common differentially expressed genes (DEGs) in keloid and hypertrophic scar samples were investigated by function and pathway analysis. Read More

    Wound healing.
    J Chin Med Assoc 2017 Nov 21. Epub 2017 Nov 21.
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Obstetric and Gynecology, National Yang-Ming University, Taipei, Taiwan, ROC; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
    Wound healing is an important physiological process to maintain the integrity of skin after trauma, either by accident or by intent procedure. The normal wound healing involves three successive but overlapping phases, including hemostasis/inflammatory phase, proliferative phase, and remodeling phase. Aberration of wound healing, such as excessive wound healing (hypertrophic scar and keloid) or chronic wound (ulcer) impairs the normal physical function. Read More

    The Superficial Dermis May Initiate Keloid Formation: Histological Analysis of the Keloid Dermis at Different Depths.
    Front Physiol 2017 7;8:885. Epub 2017 Nov 7.
    The Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce. The aim of this study was to investigate the histology of the keloid dermis at different depths. This study included 19 keloid tissue samples that were collected from 19 patients and 19 normal skin samples, which were harvested from subjects without keloids or hypertrophic scar. Read More

    Surgical management of extensive hypertrophic scarring of the halluces secondary to a decade of untreated onychocryptosis: An illustrative case report.
    SAGE Open Med Case Rep 2017 6;5:2050313X17740514. Epub 2017 Nov 6.
    Australasian College of Podiatric Surgeons, Melbourne, VIC, Australia.
    Extensive hypertrophic scarring of the halluces secondary to chronic onychocryptosis is a rare condition, which causes significant physical and psychosocial effects. In this case, a 31-year-old male developed large lesions on both great toes after he delayed treatment of chronic hallucal onychocryptosis for over a decade. Current treatment options for hypertrophic and keloid lesions in the foot and ankle vary considerably and differentiation is critical for appropriate treatment planning. Read More

    The role of TGFβ in wound healing pathologies.
    Mech Ageing Dev 2017 Nov 11. Epub 2017 Nov 11.
    Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
    Wound healing is one of the most complex processes in multicellular organisms, involving numerous intra- and intercellular signalling pathways in various cell types. It involves extensive communication between the cellular constituents of diverse skin compartments and its extracellular matrix. Miscommunication during healing may have two distinct damaging consequences: the development of a chronic wound or the formation of a hypertrophic scar/keloid. Read More

    [Therapy of scars with lasers].
    Hautarzt 2018 Jan;69(1):17-26
    Skin House, Mailand, Italien.
    Scar formation is the consequence of trauma to the skin that affects the deep parts of the dermis. Different scar types like immature, mature, atrophic, hypertrophic, or keloid scars can develop depending on factors like age, anatomic localization, cause of trauma, the course of the healing process, and individual predispositions. Keloids and hypertrophic scars are often associated with itching, pain, tautness of the skin, and functional impairments, thus, leading to significantly reduced quality of life in some patients. Read More

    The tension biology of wound healing.
    Exp Dermatol 2017 Nov 4. Epub 2017 Nov 4.
    International Research Center of Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan.
    Following skin wounding, the healing outcome can be: regeneration, repair with normal scar tissue, repair with hypertrophic scar tissue or the formation of keloids. The role of chemical factors in wound healing has been extensively explored, and while there is evidence suggesting the role of mechanical forces, its influence is much less well defined. Here, we provide a brief review on the recent progress of the role of mechanical force in skin wound healing by comparing laboratory mice, African spiny mice, fetal wound healing and adult scar keloid formation. Read More

    Observer-blind randomized controlled study of a cosmetic blend of safflower, olive and other plant oils in the improvement of scar and striae appearance.
    Int J Cosmet Sci 2017 Nov 2. Epub 2017 Nov 2.
    proDERM, Institute for Applied Dermatological Research GmbH, Kiebitzweg 2, Schenefeld/Hamburg, DE 22869, Germany.
    Objective: The normal process of skin tissue repair following injury invariably results in visual scarring. It is known that topical treatment with hydrophobic cosmetics rich in silicone and mineral oil content can improve the appearance of scars and striae. Given lifestyle preferences of many cosmetic consumers towards so-called natural treatments, the objective of this controlled randomized study was to investigate the efficacy of a plant body oil rich in oleic and linoleic acids (Bio Skin Oil® ) for improving the appearance of scars and striae. Read More

    Downregulation of microRNA-31 inhibits proliferation and induces apoptosis by targeting HIF1AN in human keloid.
    Oncotarget 2017 Sep 16;8(43):74623-74634. Epub 2017 Aug 16.
    Department of Dermatology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
    microRNAs (miRNAs) play a pivotal role in the regulation of cell proliferation and apoptosis in keloid scarring. Integrative analysis of the previous miRNA microarray revealed miRNA-31 was among the most frequently altered miRNAs in keloid and hypertrophic scar. Using qRT-PCR, we further validated miRNA-31 was increased in keloid tissues and keloid-derived fibroblasts. Read More

    A novel model of humanised keloid scarring in mice.
    Int Wound J 2017 Oct 27. Epub 2017 Oct 27.
    Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, P.R. China.
    Treatments for keloid scarring are a major challenge to scientists and physicians for their unknown aetiology. Although several models, including monolayer cell culture to tissue-engineered models, were developed, further research on keloid has more or less been hindered by the lack of appropriate animal models. Because these aberrant scars are specific to humans, we obtained human normal and keloid skin tissues and isolated dermal fibroblasts from them. Read More

    Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids.
    Medicine (Baltimore) 2017 Oct;96(43):e8353
    aDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine bShanghai Key Laboratory of Tissue Engineering, Shanghai, China.
    Intralesional steroid injections are the standard treatment for hypertrophic scars and keloids. The procedure is, however, quite painful and is unpopular with patients because of this. Topical application of anesthetic creams, such as Ametop gel (tetracaine) and EMLA cream (lidocaine and prilocaine), has limited efficacy because of poor drug penetration. Read More

    [Advances in the research of treatment of angiogenesis inhibitor on pathological scars].
    Zhonghua Shao Shang Za Zhi 2017 Oct;33(10):653-656
    Department of Burns and Plastic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China.
    Angiogenesis inhibitors are a class of agents that prevent the angiogenesis by inhibiting the activation, migration, and proliferation of endothelial cells. In recent years, studies have found that there was a close relationship between the occurrence of pathological scars and angiogenesis. The vascular density in pathological scars is significantly higher than that in normal skin and scars. Read More

    Effects of Topical Tamoxifen on Wound Healing of Burned Skin in Rats.
    Arch Plast Surg 2017 Sep 15;44(5):378-383. Epub 2017 Sep 15.
    Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
    Background: This study aimed to assess the effects of the topical application of tamoxifen on wound healing of burned skin in Wistar rats by evaluating 3 healing characteristics: fibrotic tissue thickness (FTT), scar surface area (SSA), and angiogenesis in the healed scar tissue.

    Methods: Eighteen male Wistar rats were used in this study. A third-degree burn wound was made on the shaved animals' back, measuring 2×2×2 cm. Read More

    Microneedle physical contact as a therapeutic for abnormal scars.
    Eur J Med Res 2017 Aug 14;22(1):28. Epub 2017 Aug 14.
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457, Singapore.
    Background: Abnormal (keloid and hypertrophic) scars are a significant affliction with no satisfactory single modality therapy to-date. Available options are often ineffective, painful, potentially hazardous, and require healthcare personnel involvement. Herein a self-administered microneedle device based on drug-free physical contact for inhibiting abnormal scars is reported. Read More

    Evaluation of nonablative fractional laser treatment in scar reduction.
    Lasers Med Sci 2017 Sep 12;32(7):1629-1635. Epub 2017 Aug 12.
    Department of Dermatology, Koç University School of Medicine, Davutpasa Cad, No:4, Topkapı, 34010, Istanbul, Turkey.
    Fractional lasers have been used for the improvement of scar tissue in the recent years but there has not been extensive research on their impact. The purpose of this study was to evaluate the efficacy of nonablative fractional laser (NAFL) on acne, burn, and surgery/traumatic scar. The scars were also categorized as atrophic, hypertrophic, and keloid, and treatment efficacy was investigated accordingly. Read More

    The "Sandwich Therapy": A Microsurgical Integrated Approach for Presternal Keloid Treatment.
    Ann Plast Surg 2017 Sep;79(3):280-285
    From the Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
    Background: Keloid therapy remains a great challenge for plastic surgeons, especially when the defect cannot be closed primarily, necessitating tissue transplantation. Here, we introduce a new treatment modality, called the sandwich therapy, for presternal keloids; the sandwich therapy incorporates preradiotherapy, superficial circumflex iliac artery perforator (SCIP) flap transplantation, and postradiotherapy.

    Methods: From December 2012 to October 2013, 12 patients received the "sandwich therapy. Read More

    MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment.
    Mol Diagn Ther 2017 Dec;21(6):633-642
    Department of Physiology, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong, Kunming, 650500, Yunnan, China.
    Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix. However, the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-21 may play pivotal roles in the regulation of a variety of skin fibrosis, including keloid, scleroderma, and hypertrophic scar. Read More

    Isotretinoin and Timing of Procedural Interventions: A Systematic Review With Consensus Recommendations.
    JAMA Dermatol 2017 Aug;153(8):802-809
    Pennsylvania State University, Hershey.
    Importance: The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s.

    Objective: To evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions performed either concurrently with, or immediately following the cessation of systemic isotretinoin therapy.

    Evidence Review: A panel of national experts in pediatric dermatology, procedural/cosmetic dermatology, plastic surgery, scars, wound healing, acne, and isotretinoin was convened. Read More

    Reconstitution of Human Keloids in Mouse Skin.
    Plast Reconstr Surg Glob Open 2017 Apr 25;5(4):e1304. Epub 2017 Apr 25.
    Department of Plastic Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
    Background: Keloids are a dermal fibroproliferative scar of unknown etiology. There is no good animal model for the study of keloids, which hinders the development and assessment of treatments for keloids.

    Methods: Human keratinocytes and dermal fibroblasts were isolated from 3 human skin tissues: normal skin, white scars, and keloids. Read More

    Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection.
    Asia Pac Allergy 2017 Apr 6;7(2):115-118. Epub 2017 Apr 6.
    Division of Allergy, Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
    Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. Read More

    Safety and Patient Satisfaction of AbobotulinumtoxinA for Aesthetic Use: A Systematic Review.
    Aesthet Surg J 2017 05;37(suppl_1):S32-S44
    Full Professor of Plastic and Reconstructive Surgery, Department of Surgery, Sapienza University of Rome, Rome, Italy.
    A systematic review of the published literature (from January 2000 to January 2016) to ascertain the safety of, and patient satisfaction with, the aesthetic use of abobotulinumtoxinA was conducted. In addition to the licensed indications, other special populations were considered for discussion. The potential impact of neutralizing antibodies and systemic toxicity were also addressed. Read More

    New Uses of AbobotulinumtoxinA in Aesthetics.
    Aesthet Surg J 2017 05;37(suppl_1):S45-S58
    Dermatologist in private practice in Miami, FL, USA.
    BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

    Hypochlorous acid gel technology-Its impact on postprocedure treatment and scar prevention.
    J Cosmet Dermatol 2017 Jun 30;16(2):162-167. Epub 2017 Mar 30.
    Faculty of Medicine, McGill University,Montreal, Canada.
    Background: A pre-and postprocedure regime aimed at prevention of infection, reduction of inflammation and risk of scarring, is to enable optimal outcomes.

    Objectives: The role of a hypochlorous acid containing spray and translucent scar gel formulation that combines modified silicon oil with hypochlorous acid, was explored for pre- and postprocedure treatment and scar management.

    Methods: For this purpose a literature review was conducted to explore the value of the technology used in pre-and postprocedural regimes. Read More

    The Use of Silgel STC-SE, a Topical Silicone Gel for the Treatment and Reduction of Hypertrophic and Keloid Scars.
    Plast Reconstr Surg Glob Open 2016 Dec 23;4(12):e1183. Epub 2016 Dec 23.
    Clinical Research Department, GC Aesthetics, Cumbernauld, Scotland.
    Background: A single-center study assessing the efficacy of Nagor's Silgel STC-SE silicone gel to reduce the appearance of hypertrophic and keloid scars.

    Methods: A 16-week controlled study of 36 patients with hypertrophic or keloid scars. The subjects were divided between 2 cohorts: one assessing recently healed scars (<6 mo) and other assessing older scars (6 mo to 2 y). Read More

    Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis.
    Int J Mol Sci 2017 Mar 10;18(3). Epub 2017 Mar 10.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo 113-8603, Japan.
    Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. Read More

    Vibration Anesthesia for Pain Reduction During Intralesional Steroid Injection for Keloid Treatment.
    Dermatol Surg 2017 May;43(5):724-727
    *Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea; †Lexington High School, Lexington, Massachusetts; ‡Yonsei Star Skin & Laser Clinic, Seoul, Korea.
    Background: Patients suffer significant pain during intralesional steroid injection treatment for keloids and hypertrophic scars. Vibration anesthesia has been shown to effectively and safely alleviate pain sensations, likely by reducing pain transmission from peripheral receptors to the brain.

    Objective: The objective was to evaluate the efficacy, safety, and patient satisfaction associated with vibration anesthesia for reducing pain during intralesional corticosteroid injection. Read More

    Robotic retroauricular thyroid surgery.
    Gland Surg 2016 Dec;5(6):603-606
    Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
    Surgery is the gold standard treatment for patients with thyroid cancer or nodules suspicious for cancer. Open conventional approach is the standard surgical approach. However, a visible neck incision could be a concern for most young female patients, especially for patients with a history of healing with keloid or hypertrophic scars. Read More

    β-Adrenergic Receptor Blockers Reduce the Occurrence of Keloids and Hypertrophic Scars after Cardiac Device Implantation: A Single-Institution Case-Control Study.
    Plast Reconstr Surg 2017 May;139(5):1248-1256
    Kyoto, Fukui, and Saga, Japan From the Departments of Plastic and Reconstructive Surgery and Cardiovascular Medicine, Graduate School of Medicine, Kyoto University; the Department of Plastic and Reconstructive Surgery, Fukui Red Cross Hospital; and the Section of Clinical Cooperation System, Center for Comprehensive Community Medicine, Faculty of Medicine, Saga University.
    Background: Keloids and hypertrophic scars are characterized by excessive proliferation of fibroblasts; abnormal accumulation of extracellular matrix; and clinical findings of raised, red, itchy, and painful lesions. There are few sufficient interventions for keloids, and the development of new therapeutic agents is urgently needed. Several studies suggest that a therapeutic possibility is β-adrenergic receptor blocker treatment. Read More

    The effect of moisturizers or creams on scars: a systematic review protocol.
    JBI Database System Rev Implement Rep 2017 Jan;15(1):15-19
    1The Joanna Briggs Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Australia 2Adult Burn Service, Royal Adelaide Hospital, Adelaide, Australia.
    Review Question/objective: The objectives of the review are to identify the effect of any moisturizers or creams (medicated or unmedicated) on immature scars (linear, keloid or hypertrophic) on any persons of any age. Effects will be assessed by changes in scar activity, changes in the final appearance/cosmesis of the scar, improvements in patient reported features of scars (e.g. Read More

    Differential Expression of Hedgehog and Snail in Cutaneous Fibrosing Disorders: Implications for Targeted Inhibition.
    Am J Clin Pathol 2016 Dec;146(6):709-717
    From the Dermatopathology Unit, Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston
    Objectives: To examine Hedgehog signaling in cutaneous fibrosing disorders for which effective approved therapies are lacking, expand our knowledge of pathophysiology, and explore the rationale for targeted inhibition.

    Methods: Stain intensity and percentage of cells staining for Sonic hedgehog (Shh), Indian hedgehog (Ihh), Patched (Ptch), glycogen synthase kinase 3 β (GSK3-β), β-catenin, and Snail were evaluated in human skin biopsy specimens of keloid, hypertrophic scar (Hscar), scleroderma, nephrogenic systemic fibrosis (NSF), scar, and normal skin using a tissue microarray.

    Results: Ihh, but not Shh, was detected in a significantly larger proportion of cells for all case types. Read More

    Novel Insights on Understanding of Keloid Scar: Article Review.
    J Am Coll Clin Wound Spec 2015 Dec 30;7(1-3):1-7. Epub 2016 Nov 30.
    Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States.
    Keloid scar, dermal benign fibro-proliferative growth that extends outside the original wound and invades adjacent dermal tissue due to extensive production of extracellular matrix, especially collagen, which caused by over expression of cytokines and growth factors. Although many attempts were made to understand the exact pathophysiology and the molecular abnormalities, the pathogenesis of keloid scar is yet to be determined. Even though there are several treatment options for keloid scars include combination of medical and surgical therapies like combination of surgical removal followed by cryotherapy or intralesional steroid therapy, the reoccurrence rate is still high despite the present treatment. Read More

    Delayed allergic dermatitis presenting as a keloid-like reaction caused by sting from an Indo-Pacific Portuguese man-o'-war (Physalia utriculus).
    Clin Exp Dermatol 2017 Mar 2;42(2):182-184. Epub 2017 Jan 2.
    Department of Dermatology, Botucatu Medical School, São Paulo State University, São Paulo, Brazil.
    Cnidarian envenomations are common occurrences in the tropics that can affect holidaymakers. The cutaneous reactions are classified as immediate or delayed types. Delayed allergic reactions are persistently recurring dermatitis, which can occur within 1-4 weeks from the initial sting, and may last for several months. Read More

    A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study.
    Dermatol Surg 2017 Jan;43 Suppl 1:S37-S46
    Department of Plastic Surgery, Linkou Burn Center, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.
    Background: The formation of hypertrophic scaring (HSc) is an abnormal wound-healing response. In a previous study, an animal model with human scar tissue implanted into nude mice (BALB/c) has been successfully established. The effects of verapamil as well as combination therapy with verapamil and kenacort have been studied and compared. Read More

    Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars.
    Rev Assoc Med Bras (1992) 2016 Dec;62(9):862-866
    PhD Professor and Head of the Division of Plastic Surgery, FMRP-USP, Ribeirão Preto, SP, Brazil.
    Introduction: Since the 1980s, the use of autologous fat grafting has been growing in plastic surgery. Recently, this procedure has come to be used as a treatment for keloids and hypertrophic scars mainly due to the lack of satisfactory results with other techniques. So far, however, it lacks more consistent scientific evidence to recommend its use. Read More

    A modern method of treatment: The role of silver dressings in promoting healing and preventing pathological scarring in patients with burn wounds.
    J Med Life 2016 Jul-Sep;9(3):306-315
    Department of Plastic, Reconstructive Surgery and Burns, Clinical Emergency Hospital for Plastic, Reconstructive Surgery and Burns, Bucharest, Romania.
    Burn wounds are a global public health problem, which affects all countries, no matter the development stage and occurs in all age groups, from toddlers to elderly. In spite of burns being the cause of numerous household and work accidents, there are still no clear stated unanimous rules for their treatment. Every day new products appear on the market, each of them trying to prove more effective. Read More

    Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders.
    Med Hypotheses 2016 Nov 28;96:51-60. Epub 2016 Sep 28.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.
    Keloids and hypertrophic scars are fibroproliferative disorders (FPDs) of the skin that result from abnormal healing of injured or irritated skin. They can be called pathological or inflammatory scars. Common causes are trauma, burn, surgery, vaccination, skin piercing, folliculitis, acne, and herpes zoster infection. Read More

    Endothelial cell-derived endothelin-1 is involved in abnormal scar formation by dermal fibroblasts through RhoA/Rho-kinase pathway.
    Exp Dermatol 2017 Aug 10;26(8):705-712. Epub 2017 Mar 10.
    Department of Plastic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
    Hypertrophic scars and keloids are characterized by excessive dermal deposition of extracellular matrix due to fibroblast-to-myofibroblast differentiation. Endothelin-1 (ET-1) is primarily produced by vascular endothelial cells and plays multiple roles in the wound-healing response and organ fibrogenesis. In this study, we investigated the pathophysiological significance of ET-1 and involvement of RhoA, a member of the Rho GTPases, in hypertrophic scar/keloid formation. Read More

    Treating Scars in the Auricle Region.
    Facial Plast Surg Clin North Am 2017 Feb;25(1):73-81
    Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego, 3350 La Jolla Village Drive, 112-C, San Diego, CA 92161, USA. Electronic address:
    This article provides a review of the surgical and nonsurgical options available to manage a variety of auricular scars. The basics of wound healing are discussed in addition to the etiology of keloids and the cauliflower ear. Many auricular scars can be revised with scar excision techniques, but separate discussions for the treatment of keloids and the cauliflower ear are provided. Read More

    Comparative effect and safety of verapamil in keloid and hypertrophic scar treatment: a meta-analysis.
    Ther Clin Risk Manag 2016 9;12:1635-1641. Epub 2016 Nov 9.
    Department of Dermatology, Yanbian University Affiliated hospital, Yanji, Jilin, People's Republic of China.
    Background: Keloids and hypertrophic scars are the most common types of pathological scarring. Traditionally, keloids have been considered as a result of aberrant wound healing, involving excessive fibroblast participation that is characterized by hyalinized collagen bundles. However, the usefulness of this characterization has been questioned. Read More

    Can subphysiological cold application be utilized in excessive dermal scarring prophylaxis and treatment?: A promising hypothetical perspective.
    Med Hypotheses 2016 Dec 19;97:4-6. Epub 2016 Oct 19.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.
    Excessive dermal scarring (EDS) is a wound healing complication, characterized by protruded erythematous and inelastic 'proliferative scar tissue' which is associated with increased and prolonged inflammation process within the wound microenvironment. As inflammation plays a key role in this process, methods to contain or attenuate excessive inflammation hold promise in treatment and prophylaxis of EDS conditions. While cold exposure is notorious as the causative agent a wide array of morbidities and fatalities, its tempered use is exploited in medicine for ablative and therapeutic applications. Read More

    S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis.
    J Invest Dermatol 2017 Mar 10;137(3):650-659. Epub 2016 Nov 10.
    Laboratory for Wound Repair and Regenerative Surgery, Department of Surgery/Plastic Surgery Division, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:
    Disruption of the barrier function of skin increases transepidermal water loss and up-regulates inflammatory pathways in the epidermis. Consequently, sustained expression of proinflammatory cytokines from the epidermis is associated with dermal scarring. We found increased expression of S100A12 in the epidermis of human hypertrophic and keloid scar. Read More

    Comparing Two Methods of Cryotherapy and Intense Pulsed Light with Triamcinolone Injection in the Treatment of Keloid and Hypertrophic Scars: A Clinical Trial.
    Osong Public Health Res Perspect 2016 Oct 23;7(5):313-319. Epub 2016 Aug 23.
    Department of Dermatology, Kerman University of Medical Sciences, Kerman, Iran.
    Objectives: Keloid and hypertrophic scars are abnormal manifestations of wounds that occur following skin injuries in the form of local proliferation of fibroblasts and increased production of collagen. There are several ways to cure these scars; treatment must be selected based on the nature of the scars. In this clinical trial, two methods-cryotherapy and intense pulsed light (IPL)-are compared in the treatment of scars, and the results are presented in terms of improvement level, complications, and patient satisfaction. Read More

    Measurements of scar properties by SkinFibroMeter® , SkinGlossMeter® , and Mexameter® and comparison with Vancouver Scar Scale.
    Skin Res Technol 2017 Aug 30;23(3):295-302. Epub 2016 Oct 30.
    Department of Dermatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    Background: An objective measurement of scar is important for evaluating treatment outcomes. However, to date, there is no 'gold standard' for quantitative measurement of properties of hypertrophic scar. Existing objective modalities are neither portable nor easy to use. Read More

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