953 results match your criteria Keloid and Hypertrophic Scar


Surgery for scar revision and reduction: from primary closure to flap surgery.

Authors:
Rei Ogawa

Burns Trauma 2019 1;7. Epub 2019 Mar 1.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, 1-1-5 Sendagi Bunkyo-ku, Tokyo, 113-8603 Japan.

Scars are the final result of the four processes that constitute cutaneous wound healing, namely, coagulation, inflammation, proliferation, and remodeling. Permanent scars are produced if the wounds reach the reticular dermis. The nature of these scars depends on the four wound healing processes. Read More

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http://dx.doi.org/10.1186/s41038-019-0144-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404336PMC
March 2019
1 Read

Discussion: Treatment of Keloid Scars with Botulinum Toxin Type A versus Triamcinolone in an Athymic Nude Mouse Model.

Authors:
Rei Ogawa

Plast Reconstr Surg 2019 03;143(3):768-769

Tokyo, Japan From the Department of Plastic, Reconstructive, and Aesthetic Surgery, Nippon Medical School.

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http://dx.doi.org/10.1097/PRS.0000000000005324DOI Listing
March 2019
1 Read

The 1470 nm diode laser with an intralesional fiber device: a proposed solution for the treatment of inflamed and infected keloids.

Burns Trauma 2019 15;7. Epub 2019 Feb 15.

1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011 China.

Background: Keloids are the result of abnormal wound healing and often are subject to infections and recurrent inflammation. We present a study conducted with a 1470 nm diode laser using an intralesional optical fiber device for the treatment of inflamed keloid scars. We evaluate its efficacy as a novel alternative method to decrease keloid infection and inflammation. Read More

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http://dx.doi.org/10.1186/s41038-019-0143-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376646PMC
February 2019
1 Read

Fibrosarcomatous dermatofibrosarcoma protuberans from scar following trauma.

Autops Case Rep 2018 Oct-Dec;8(4):e2018039. Epub 2018 Sep 26.

Mercer University School of Medicine. Columbus, GA, United States of America.

Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue neoplasm of low metastatic potential notable for its progressive growth and high rate of local recurrence after surgical excision. Fibrosarcomatous transformation of DFSP (FS-DFSP) is a rare variant characterized by higher rates of local recurrence and metastasis. Trauma has been hypothesized as a potential risk factor for the development of DFSP, although clear evidence has been lacking. Read More

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http://autopsyandcasereports.org/article/doi/10.4322/acr.201
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http://dx.doi.org/10.4322/acr.2018.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360829PMC
September 2018
5 Reads

Topical Oxandrolone Reduces Ear Hypertrophic Scar Formation in Rabbits.

Plast Reconstr Surg 2019 02;143(2):481-487

Cluj-Napoca and Oradea, Romania From the Department of Plastic Surgery and Burns Unit, Emergency County Hospital Cluj, "Iuliu Haţieganu" University of Medicine and Pharmacy; and the Plastic Surgery Department, County Hospital Oradea, University of Oradea.

Background: Wound healing is a complex process. Despite extensive studies, hypertrophic and keloid scars still occur, and can be functionally and cosmetically problematic. In an attempt to prevent hypertrophic scar formation, the effects of topical oxandrolone, using hyaluronic acid as a biomaterial, were studied on ear wounds in rabbits. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005275DOI Listing
February 2019
2 Reads

Normal Expression of SRY-related HMG-BOX Gene 10 (SOX-10) in Recent and Old Cutaneous Scars is a Potential Mimicker of Desmoplastic Malignant Melanoma.

Appl Immunohistochem Mol Morphol 2019 Jan 21. Epub 2019 Jan 21.

Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL.

Desmoplastic malignant melanoma (DMM) is an amelanotic spindle cell proliferation that can be mistaken for a cutaneous scar. The distinction can be difficult in reexcisions because DMM is negative for conventional melanoma markers such as HMB-45 and Melan-A, and scars may be positive for S-100 protein and SOX-10. We compare a total of 12 DMM cases with 8 reexcision and 35 old non-reexcision cutaneous scars using SOX-10 immunohistochemical stains. Read More

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http://Insights.ovid.com/crossref?an=00129039-900000000-9874
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http://dx.doi.org/10.1097/PAI.0000000000000729DOI Listing
January 2019
12 Reads

Minimally Invasive Video-Assisted Thyroidectomy: Analysis of Complications From a Systematic Review.

Surg Innov 2019 Jan 11:1553350618823425. Epub 2019 Jan 11.

1 University of Palermo, Palermo, Italy.

Background: Nowadays, minimally invasive video-assisted thyroidectomy (MIVAT) is considered a safe and effective option. However, its complication rate has not been specifically discussed yet. The aim of this systematic review was enrolling a large number of studies to estimate early and late complications (transient and definitive, uni- and bilateral laryngeal nerve palsy; transient and definitive hypocalcemia; cervical hematoma; hypertrophic or keloid scar) of MIVAT compared with conventional technique. Read More

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http://dx.doi.org/10.1177/1553350618823425DOI Listing
January 2019
12 Reads

Detection of Angiotensin II and AT Receptor Concentrations in Keloid and Hypertrophic Scar.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):36-39. Epub 2018 Oct 1.

Drs. Niazi, Hooshyar, Doroodgar, and Niazi are with the Department of Plastic and Reconstructive Surgery at Modarres Hospital School of Medicine at Shahid Beheshti University of Medical Sciences in Tehran, Iran.

Keloid and hypertrophic scars (HTS) are formed by excessive collagen formation. Angiotensin II, through the AT receptor, plays an important role in extracellular matrix production. However, less is known about angiotensin II and AT receptor concentrations in HTS and keloid tissues. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239163PMC
October 2018
7 Reads

A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin.

J Invest Dermatol 2018 Nov 22. Epub 2018 Nov 22.

miRagen Therapeutics, Inc, Boulder, Colorado, USA.

MicroRNA-29 (miR-29) negatively regulates fibrosis and is downregulated in multiple fibrotic organs and tissues, including in the skin. miR-29 mimics prevent pulmonary fibrosis in mouse models but have not previously been tested in the skin. This study aimed to identify pharmacodynamic biomarkers of miR-29 in mouse skin, to translate those biomarkers across multiple species, and to assess the pharmacodynamic activity of a miR-29b mimic (remlarsen) in a clinical trial. Read More

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http://dx.doi.org/10.1016/j.jid.2018.11.007DOI Listing
November 2018
4 Reads

Two Cases of Granular Cell Tumors that Clinically Mimicked Hypertrophic Scars and Keloids.

J Nippon Med Sch 2018 ;85(5):279-282

Department of Plastic, Reconstructive & Aesthetic Surgery, Nippon Medical School.

We report two cases of granular cell tumors (GCTs) arising on rare sites, namely, the nape and umbilicus. While GCTs have a very characteristic histology, their clinical signs and symptoms are non-specific. Therefore, it is extremely difficult to make a diagnosis of GCT on the basis of clinical findings only. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2018_85-44DOI Listing
February 2019
5 Reads

Combined Non-Ablative Laser and Microfat Grafting for Burn Scar Treatment.

Aesthet Surg J 2019 Mar;39(4):NP55-NP67

ONEP Plastic Surgery Science Institute, Istanbul, Turkey.

Background: Burn scar treatment persists as an unsolved problem, involving thousands of affected patients disfigured for life.

Objectives: We sought to present our experience with the use of combined treatments for patients with burn scars.

Methods: This was a case series report of the senior author's experience during 8 years utilizing the combined treatments of Fraxel Restore (fractional laser) and microfat graft injection for 288 patients with burn scars. Read More

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https://academic.oup.com/asj/advance-article/doi/10.1093/asj
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http://dx.doi.org/10.1093/asj/sjy291DOI Listing
March 2019
6 Reads

Reconstructed human keloid models show heterogeneity within keloid scars.

Arch Dermatol Res 2018 Dec 28;310(10):815-826. Epub 2018 Oct 28.

Department of Molecular Cell Biology and Immunology, O|2 Lab Building, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Keloid scars are often described as having an actively growing peripheral margin with a regressing centre. The aim of this study was to examine the possible heterogeneity within keloids and the involvement of different regions within and around keloid scars in the pathogenesis, using an in vitro keloid scar model. In vitro skin models were constructed from keratinocytes and fibroblasts from normal skin and different regions within and around keloid scars: periphery, centre, and (adjacent) surrounding-normal-skin regions. Read More

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http://dx.doi.org/10.1007/s00403-018-1873-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244653PMC
December 2018
3 Reads

Adipose-derived mesenchymal stem cells treatments for fibroblasts of fibrotic scar via downregulating TGF-β1 and Notch-1 expression enhanced by photobiomodulation therapy.

Lasers Med Sci 2019 Feb 26;34(1):1-10. Epub 2018 Oct 26.

Ninth Department of Plastic Surgery, Plastic Surgery Hospital of Chinese Academy of Medical Sciences, No. 33, Ba-Da-Chu Road, Beijing, China.

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http://dx.doi.org/10.1007/s10103-018-2567-9DOI Listing
February 2019
2 Reads

Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial.

Burns 2019 02 16;45(1):69-75. Epub 2018 Oct 16.

Jinnah Burn and Reconstructive Surgery Center, Allama Iqbal Medical College, Lahore, Pakistan.

The treatment of keloid and hypertrophic scar is challenging with no universally accepted mode for permanent ablation. Conventional therapies yield unpredictable results, significant complications and require elaborate hardware.

Objective: The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars. Read More

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http://dx.doi.org/10.1016/j.burns.2018.08.011DOI Listing
February 2019
6 Reads

Arm Contouring After Massive Weight Loss: Liposuction-Assisted Brachioplasty Versus Standard Technique.

J Cutan Aesthet Surg 2018 Apr-Jun;11(2):73-78

Department of Plastic and Reconstructive Surgery, University of Rome "Tor Vergata", Rome, Italy.

Massive weight loss (MWL) brachioplasty is frequently requested for the improvement of the appearance and function of arms. Despite its diffusion, this procedure can be associated with significant complications. Liposuction-assisted brachioplasty (LAB) preserves the vascular, nervous, and lymphatic network and reduces the incidence of postoperative complications. Read More

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http://dx.doi.org/10.4103/JCAS.JCAS_102_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128150PMC
September 2018
7 Reads

Keloid formation after pediatric male genital surgeries: an uncommon and difficult problem to manage.

J Pediatr Urol 2019 Feb 8;15(1):48.e1-48.e8. Epub 2018 Aug 8.

Division of Urology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada; Department of Surgery, Division of Urology, Sidra Medical and Research Center, Doha, Qatar.

Introduction: Penile and genital keloids are uncommon despite frequent surgeries in the genital area. Keloid scar pathogenesis is not well understood, and a uniform effective therapeutic regimen for keloids has not yet been established. In the present study, the clinical features and subsequent management in cases of severe keloid formation after pediatric genital surgery are described. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14775131183043
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http://dx.doi.org/10.1016/j.jpurol.2018.08.003DOI Listing
February 2019
4 Reads

Epidermolysis Bullosa Patients' Perception of Surgical Wound and Scar Healing.

Dermatol Surg 2019 02;45(2):280-289

Department of Dermatology, St. George Hospital, Sydney, Australia.

Background: There is limited evidence to suggest patients with epidermolysis bullosa (EB) have more postoperative wound complications than the general population. Despite this, the authors have noted reluctance among some surgeons to operate on these patients.

Objective: A cross-sectional study was designed to investigate postoperative wound and scar healing outcomes in patients with EB. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001673DOI Listing
February 2019
2 Reads

Current and upcoming therapies to modulate skin scarring and fibrosis.

Adv Drug Deliv Rev 2018 Aug 30. Epub 2018 Aug 30.

Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Biomedical Sciences Building, National University of Ireland Galway (NUI, Galway), Galway, Ireland; Science Foundation Ireland (SFI), Centre for Research in Medical Devices (CÚRAM), Biomedical Sciences Building, National University of Ireland Galway (NUI, Galway), Galway, Ireland. Electronic address:

Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response that invariably ends in the formation of scar at the wounded dermal area. Read More

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http://dx.doi.org/10.1016/j.addr.2018.08.009DOI Listing
August 2018
26 Reads

Management of epidermal cysts arising from scar tissues: A retrospective clinical study.

Medicine (Baltimore) 2018 Aug;97(35):e12188

Department of Plastic and Reconstructive Surgery, Konyang University Hospital, University of Konyang College of Medicine, Myunggok Medical Research Center, Daejeon.

Few reports have described epidermal cysts (ECs) arising from scar tissues, and the standard course of treatment has not been established. We aimed to report the findings of a Korean patient series with ECs arising from scar tissues, to describe patient management in the context of previous publications, and to present a simple algorithm for managing ECs arising from scar tissues.We managed 6 patients with ECs arising from scar tissues, and retrospectively reviewed their demographic and clinical data. Read More

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http://dx.doi.org/10.1097/MD.0000000000012188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393145PMC
August 2018
14 Reads

Incidence of and Risk Factors for Cutaneous Scarring after Herpes Zoster.

Am J Clin Dermatol 2018 Dec;19(6):893-897

Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgium.

Background: About 20% of children have cutaneous scars following chickenpox. In contrast, skin scars are not often reported after herpes zoster (HZ). Risk factors for post-HZ scarring remain undetermined. Read More

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http://dx.doi.org/10.1007/s40257-018-0385-2DOI Listing
December 2018
8 Reads

Exuberant keloid scar associated with skin neoplasia.

Rev Assoc Med Bras (1992) 2018 04;64(4):315-317

Medical Academic at the Álvaro Alvim University Hospital/HEAA - Campos dos Goytacazes/RJ. Work performed at the Dermatology Department of the Álvaro Álvim University Hospital/HEAA, located at Rua Barão da Lagoa Dourada, 409, Campos dos Goytacazes, Rio de Janeiro.

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http://dx.doi.org/10.1590/1806-9282.64.04.315DOI Listing
April 2018
1 Read

Losartan ointment relieves hypertrophic scars and keloid: A pilot study.

Wound Repair Regen 2018 07 25;26(4):340-343. Epub 2018 Oct 25.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Keloid and hypertrophic scars are two types of fibrosis caused by extracellular matrix overexpression, and angiotensin II via AT receptor is known to play a key role in stimulation of fibrosis. A pilot placebo controlled single blind study was carried out on patients with hypertrophic scars and keloids. A total of 37 adult volunteers were randomly assigned into losartan 5% or placebo treatment groups. Read More

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http://doi.wiley.com/10.1111/wrr.12648
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http://dx.doi.org/10.1111/wrr.12648DOI Listing
July 2018
32 Reads

[Calidad de vida en adultos con cicatrices queloides].

Cir Cir 2018 ;86(4):321-326

Unidad de Investigación, Centro Dermatológico Dr. Ladislao de la Pascua, Servicios de Salud Pública, Ciudad de México, México.

Introducción: Las cicatrices queloides afectan hasta el 16% de la población hispana y pueden causar un deterioro en la calidad de vida. La mayoría de los estudios previos han estudiado pacientes con cicatrices hipertróficas secundarias a quemaduras.

Objetivo: Determinar la calidad de vida en adultos con cicatrices queloides que acuden a un centro dermatológico. Read More

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http://dx.doi.org/10.24875/CIRU.M18000049DOI Listing
March 2019
3 Reads

Isotretinoin and dermatosurgical procedures.

Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):18-23

Department of Dermatologist, Inlaks and Budhrani Hospital, Pune, Maharashtra, India.

Several early reports suggested that performance of dermatosurgical procedures in patients on oral isotretinoin is associated with abnormal skin healing, keloid or hypertrophic scar formation. However, this association has been recently questioned in some studies. This review examines this issue, analyzes the studies published and concludes that the recommendation made earlier about the need to avoid dermatosurgical procedures in patients on isotretinoin is based on inadequate and insufficient evidence and hence needs revision. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_96_17DOI Listing
April 2019
5 Reads

Photobiomodulation therapy promotes in vitro wound healing in nicastrin KO HaCaT cells.

J Biophotonics 2018 Dec 24;11(12):e201800174. Epub 2018 Jul 24.

University of Trieste, Trieste, Italy.

Mutations in NCSTN gene (encoding for nicastrin protein) are associated with hidradenitis suppurativa (HS), a chronic inflammatory disease involving hair follicles. HS is clinically handled with drugs but the most severe cases are treated with surgery. Photobiomodulation (PBM) therapy, already used in the treatment of skin diseases such as acne, herpes virus lesions, ultraviolet damage, vitiligo, hypertrophic scar, keloid, burn, psoriasis and diabetic chronic wounds, could be beneficial as an adjuvant supportive treatment to promote and foster the healing process after skin excision in HS. Read More

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http://dx.doi.org/10.1002/jbio.201800174DOI Listing
December 2018
17 Reads
4.450 Impact Factor

Scars: impact and management, with a focus on topical silicone-based treatments.

Br J Nurs 2018 Jun;27(Sup12):S36-S40

Dermatology Educator and Adviser, Dermatology Education Partnership.

Many people are living with scars caused by surgery or traumatic injury. Scar prevention in the early stages of wound healing is an essential aspect of care. Ongoing scar management is generally by self-care, using non-invasive methods such as silicone sheeting and/or massage. Read More

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http://www.magonlinelibrary.com/doi/10.12968/bjon.2018.27.Su
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http://dx.doi.org/10.12968/bjon.2018.27.Sup12.S36DOI Listing
June 2018
6 Reads

Distensibility and Gross Elasticity of the Skin at Various Body Sites and Association with Pathological Scarring: A Case Study.

J Clin Aesthet Dermatol 2018 Jun 1;11(6):15-18. Epub 2018 Jun 1.

Drs. Hokazono, Sano, and Ogawa are with the Department of Plastic, Reconstructive, and Aesthetic Surgery at Nippon Medical School in Tokyo, Japan.

Pathological scars, including hypertrophic scars and keloids, have a strong predilection for specific regions of the body. Such site specificity might reflect regional differences in skin properties. Greater knowledge about the characteristics of the skin at various body regions can promote the development of clinical approaches to skin incision and flap design and reduce the formation of cutaneous scars. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011867PMC
June 2018
1 Read

Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: A randomized controlled trial.

Burns 2018 09 7;44(6):1482-1488. Epub 2018 Jun 7.

Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Keloids and hypertrophic scars are due to overgrowth of dermal collagen following trauma to the skin that usually cause major physical, psychological and cosmetic problems.

Methods: In this randomized controlled trial, with a paired design, 50 patients with 2 or more keloids were included. In the control group (50 lesions), intralesional triamcinolone acetonide (40mg/mL) was injected at three-week intervals for a total of 18weeks. Read More

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http://dx.doi.org/10.1016/j.burns.2018.05.005DOI Listing
September 2018
26 Reads

Novel Stereoscopic Optical System for Objectively Measuring Above-Surface Scar Volume-First-Time Quantification of Responses to Various Treatment Modalities.

Dermatol Surg 2018 Jun;44(6):848-854

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Current approaches use subjective semiquantitative or cumbersome objective methodologies to assess physical characteristics of hypertrophic and keloid scars.

Objective: This pilot study aimed to evaluate the accuracy and feasibility of a new stereoscopic optical and high-resolution 3-dimensional imaging system, for objectively measuring changes in above-surface scar volume after various interventions.

Methods: Feasibility and accuracy were assessed by monitoring the above-surface scar volume of 5 scars in 2 patients for 5 successive months. Read More

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http://Insights.ovid.com/crossref?an=00042728-201806000-0001
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http://dx.doi.org/10.1097/DSS.0000000000001434DOI Listing
June 2018
4 Reads

Intralesional cryotherapy for hypertrophic scars and keloids: a review.

Scars Burn Heal 2017 Jan-Dec;3:2059513117702162. Epub 2017 Apr 17.

School of Medicine, Queen Mary University London, UK.

Introduction: Hypertrophic and keloid scarring remain notoriously troublesome for patients to tolerate and frustratingly difficult for clinicians to treat. Many different treatment modalities exist, signifying the failure of any method to achieve consistently excellent results. Intralesional cryotherapy is a relatively recent development that uses a double lumen needle, placed through the core of a keloid or hypertrophic scar, to deliver nitrogen vapour, which freezes the scar from its core, outwards. Read More

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http://dx.doi.org/10.1177/2059513117702162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965337PMC
April 2017
4 Reads

Autologous fat grafting in keloids and hypertrophic scars: a review.

Scars Burn Heal 2017 Jan-Dec;3:2059513117700157. Epub 2017 Apr 6.

Department of Surgery, School of Clinical Science at Monash Health, Monash University, Monash Medical Centre, Victoria, Australia.

Keloid and hypertrophic scars are unique human dermal fibroproliferative disorders of the injured skin and are associated with pain, itch and can cause functional limitations. A number of genetic, systemic and local factors have been identified in the formation of keloids and hypertrophic scars. Studies have shown that adipose-derived stem cells have angiogenic and antiapoptotic properties which has effects on wound healing, soft-tissue restoration and scar remodelling, and thus may have a role in managing keloid scaring. Read More

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http://dx.doi.org/10.1177/2059513117700157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965318PMC
April 2017
1 Read

Human recombinant epidermal growth factor in skin lesions: 77 cases in EPItelizando project.

J Dermatolog Treat 2019 Feb 10;30(1):96-101. Epub 2018 May 10.

a Centro Médico Teknon , Barcelona , Spain.

Objective: To analyze compounded recombinant human epidermal growth factor (rhEGF) effectiveness on skin lesions through a case series.

Design: Multicentric series of skin lesions treated with topical rhEGF. Site: Patients from 56 different health professionals, three different countries, and two recruitment years. Read More

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http://dx.doi.org/10.1080/09546634.2018.1468546DOI Listing
February 2019
41 Reads

Corneal fibroma: An uncommon stromal tumor.

Indian J Ophthalmol 2018 05;66(5):699-701

Mehta Eye Clinic, Ghatkopar, Mumbai, India.

A 56-year-old male patient presented with a slow-growing, elevated, smooth, white corneal mass. The mass was excised by performing an alcohol-assisted keratoepitheliectomy and sent for histopathological examination. Subepithelially, closely packed spindle cells in "feather-stitched" or storiform pattern were seen. Read More

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http://dx.doi.org/10.4103/ijo.IJO_936_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939170PMC
May 2018
5 Reads

Centella asiatica (Centellicum®) facilitates the regular healing of surgical scars in subjects at high risk of keloids.

Minerva Chir 2018 Apr;73(2):151-156

IRVINE3 Labs, Chieti-Pescara University, Chieti, Italy.

Background: Formation of scars after surgical incisions requires the proper appositions of elements contributing to the scarring process. The structural rebuilding of damaged tissues is essential in producing a linear scar. The excess of blood, foreign particles, exuberant sutures, necrotic tissue, possible infective agents, as well as the ongoing inflammatory process may produce a non-linear, sometimes painful keloidal scar. Read More

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http://dx.doi.org/10.23736/S0026-4733.18.07666-6DOI Listing
April 2018
35 Reads

Efficacy and possible mechanisms of Botulinum Toxin type A on hypertrophic scarring.

J Cosmet Dermatol 2018 Jun 23;17(3):340-346. Epub 2018 Mar 23.

Department of Skin Cosmetology, Traditional Chinese Medicine Hospital of Chongqing, Chongqing, China.

Background: Clinical observations indicate that Botulinum toxin type A (BTXA) can inhibit the growth and improve the eventual appearance of hypertrophic scarring. However, the molecular mechanism remains unclear.

Objective: We used human keloid fibroblasts to investigate the molecular mechanism of BTXA on hypertrophic scarring. Read More

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http://doi.wiley.com/10.1111/jocd.12534
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http://dx.doi.org/10.1111/jocd.12534DOI Listing
June 2018
28 Reads

Mechanical forces in skin disorders.

J Dermatol Sci 2018 Jun 8;90(3):232-240. Epub 2018 Mar 8.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; International Research Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Mechanical forces are known to regulate homeostasis of the skin and play a role in the pathogenesis of skin diseases. The epidermis consists of keratinocytes that are tightly adhered to each other by cell junctions. Defects in keratins or desmosomal/hemidesmosomal proteins lead to the attenuation of mechanical strength and formation of intraepidermal blisters in the case of epidermolysis bullosa simplex. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.03.004DOI Listing
June 2018
14 Reads
3.419 Impact Factor

Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids.

Int J Mol Sci 2018 Mar 2;19(3). Epub 2018 Mar 2.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus, these significantly affect patients' quality of life. There have been many studies on hypertrophic scars and keloids; but the mechanisms underlying scar formation have not yet been well established, and prophylactic and treatment strategies remain unsatisfactory. Read More

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http://dx.doi.org/10.3390/ijms19030711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877572PMC
March 2018
8 Reads

Characterization of In Vitro Reconstructed Human Normotrophic, Hypertrophic, and Keloid Scar Models.

Tissue Eng Part C Methods 2018 04 2;24(4):242-253. Epub 2018 Apr 2.

1 Department of Dermatology, VU Medical Centre (VUMC) , Amsterdam, The Netherlands .

To understand scar pathology, develop new drugs, and provide a platform for personalized medicine, physiologically relevant human scar models are required, which are characteristic of different scar pathologies. Hypertrophic scars and keloids are two types of abnormal scar resulting from unknown abnormalities in the wound healing process. While they display different clinical behavior, differentiation between the two can be difficult-which in turn means that it is difficult to develop optimal therapeutic strategies. Read More

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http://dx.doi.org/10.1089/ten.TEC.2017.0464DOI Listing
April 2018
41 Reads

Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study.

Int Wound J 2018 Aug 21;15(4):538-546. Epub 2018 Feb 21.

Wound Healing and Cytoprotection Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba.

Hypertrophic scars (HTS) and keloids are forms of aberrant cutaneous healing with excessive extracellular matrix (ECM) deposition. Current therapies still fall short and cause undesired effects. We aimed to thoroughly evaluate the ability of growth hormone releasing peptide 6 (GHRP6) to both prevent and reverse cutaneous fibrosis and to acquire the earliest proteome data supporting GHRP6's acute impact on aesthetic wound healing. Read More

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http://dx.doi.org/10.1111/iwj.12895DOI Listing
August 2018
18 Reads

The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review.

Dermatol Surg 2018 Feb;44(2):149-157

Department of Dermatology, University of California at Davis, Sacramento, California.

Background: Keloids and hypertrophic scars are conditions of pathologic scarring characterized by fibroblast hyperproliferation and excess collagen deposition. These conditions significantly impact patients by causing psychosocial, functional, and aesthetic distress. Current treatment modalities have limitations. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001360DOI Listing
February 2018
23 Reads

A new treatment of hypertrophic and keloid scars with combined triamcinolone and verapamil: a retrospective study.

Eur J Plast Surg 2018 8;41(1):69-80. Epub 2017 Jun 8.

1Department of Plastic Surgery, Maastricht University Medical Center, P Debyelaan 25, 6229HX Maastricht, The Netherlands.

Background: Since the management of keloid and hypertrophic scars still remains a difficult clinical problem, there is need for adequate, effective therapy. In this study, we explored for the first time the efficacy and the potential synergetic effect of combined triamcinolone and verapamil for the treatment of hypertrophic and keloid scars. The objective was to assess the efficacy of combined intralesional triamcinolone and verapamil therapy for hypertrophic and keloid scars. Read More

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http://dx.doi.org/10.1007/s00238-017-1322-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780547PMC
June 2017
5 Reads

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation.

Adv Wound Care (New Rochelle) 2018 Feb;7(2):47-56

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California.

Excessive scarring is major clinical and financial burden in the United States. Improved therapies are necessary to reduce scarring, especially in patients affected by hypertrophic and keloid scars. Advances in our understanding of mechanical forces in the wound environment enable us to target mechanical forces to minimize scar formation. Read More

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http://dx.doi.org/10.1089/wound.2016.0709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792236PMC
February 2018
20 Reads

[Advances in the research of relationship between CD26 and hypertrophic scar and keloid].

Authors:
C L Song M Yao

Zhonghua Shao Shang Za Zhi 2018 Jan;34(1):54-56

Department of Plastic Surgery and Burns, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China.

In recent years, researchers have found that CD26 (dipeptidyl peptidase 4) is closely related to the formation and development of many fibrotic diseases. Hypertrophic scar, keloid, and other skin fibrosis diseases are major problems nowadays, which may affect the patient's appearance and cause joints deformity and dysfunction due to scar contracture. This article briefly reviews the relationship between CD26 and hypertrophic scar and keloid to provide new insights into the treatment of skin fibrotic diseases. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2018.01.011DOI Listing
January 2018
1 Read

Inhibition of IRE1 results in decreased scar formation.

Wound Repair Regen 2017 11 6;25(6):964-971. Epub 2018 Feb 6.

Department of Surgery, Stanford University School of Medicine, Stanford, California.

Wound healing is characterized by the production of large amounts of protein necessary to replace lost cellular mass and extracellular matrix. The unfolded protein response (UPR) is an important adaptive cellular response to increased protein synthesis. One of the main components of the UPR is IRE1, an endoplasmic reticulum transmembrane protein with endonuclease activity that produces the activated form of the transcription factor XBP1. Read More

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http://dx.doi.org/10.1111/wrr.12603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854534PMC
November 2017
9 Reads

Commentary on The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review.

Dermatol Surg 2018 02;44(2):158

Carruthers Dermatology Centre, Dermatology Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/DSS.0000000000001425DOI Listing
February 2018
16 Reads

Comparison of the effectiveness of topical silicone gel and corticosteroid cream on the pfannenstiel scar prevention - a randomized controlled trial.

Ginekol Pol 2017 ;88(11):591-598

Acıbadem Kozyatagı Hospital, Department of Obstetrics and Gynecology, Inonu Caddesi, Okur Sokak, No:20 Kozyatagı, 34742 Istanbul, Turkey.

Objectives: To compare the effects of topical silicone gel and corticosteroid cream for preventing hypertrophic scar and keloid formation following Pfannenstiel incisions.

Material And Methods: Fifty patients operated for benign gynecological diseases through primary Pfannenstiel incision were included. The wounds were randomly allocated to the treatment and control arms. Read More

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http://dx.doi.org/10.5603/GP.a2017.0107DOI Listing
July 2018
11 Reads

High-Mobility Group Box 1 Mediates Fibroblast Activity via RAGE-MAPK and NF-κB Signaling in Keloid Scar Formation.

Int J Mol Sci 2017 Dec 28;19(1). Epub 2017 Dec 28.

Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul 03722, Korea.

Emerging studies have revealed the involvement of high-mobility group box 1 (HMGB1) in systemic fibrotic diseases, yet its role in the cutaneous scarring process has not yet been investigated. We hypothesized that HMGB1 may promote fibroblast activity to cause abnormal cutaneous scarring. In vitro wound healing assay with normal and keloid fibroblasts demonstrated that HMGB1 administration promoted the migration of both fibroblasts with increased speed and a greater traveling distance. Read More

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http://dx.doi.org/10.3390/ijms19010076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796026PMC
December 2017
17 Reads

Techniques for Optimizing Surgical Scars, Part 2: Hypertrophic Scars and Keloids.

Skinmed 2017 1;15(6):451-456. Epub 2017 Dec 1.

Refresh Dermatology, Houston, TX;

Surgical management of benign or malignant cutaneous tumors may result in noticeable scars that are of great concern to patients, regardless of sex, age, or ethnicity. Techniques to optimize surgical scars are discussed in this three-part review. Part 2 focuses on scar revision for hypertrophic and keloids scars. Read More

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December 2017
13 Reads

Identification of the potential targets for keloid and hypertrophic scar prevention.

J Dermatolog Treat 2018 Sep 10;29(6):600-605. Epub 2018 Jan 10.

b Department of Thyroid Surgery , China-Japan Union Hospital of Jilin University , Changchun , China.

Purpose: We aimed to explore the molecular mechanism of pathologic skin scar and novel target for scar prevention.

Materials And Methods: Microarray data derived from keloid and hypertrophic scar were downloaded from ArrayExpress database. The common differentially expressed genes (DEGs) in keloid and hypertrophic scar samples were investigated by function and pathway analysis. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2017.1
Publisher Site
http://dx.doi.org/10.1080/09546634.2017.1421309DOI Listing
September 2018
15 Reads