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    845 results match your criteria Keloid and Hypertrophic Scar

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    Robotic retroauricular thyroid surgery.
    Gland Surg 2016 Dec;5(6):603-606
    Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
    Surgery is the gold standard treatment for patients with thyroid cancer or nodules suspicious for cancer. Open conventional approach is the standard surgical approach. However, a visible neck incision could be a concern for most young female patients, especially for patients with a history of healing with keloid or hypertrophic scars. Read More

    The effect of moisturizers or creams on scars: a systematic review protocol.
    JBI Database System Rev Implement Rep 2017 Jan;15(1):15-19
    1The Joanna Briggs Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Australia 2Adult Burn Service, Royal Adelaide Hospital, Adelaide, Australia.
    Review Question/objective: The objectives of the review are to identify the effect of any moisturizers or creams (medicated or unmedicated) on immature scars (linear, keloid or hypertrophic) on any persons of any age. Effects will be assessed by changes in scar activity, changes in the final appearance/cosmesis of the scar, improvements in patient reported features of scars (e.g. Read More

    Differential Expression of Hedgehog and Snail in Cutaneous Fibrosing Disorders: Implications for Targeted Inhibition.
    Am J Clin Pathol 2016 Dec;146(6):709-717
    From the Dermatopathology Unit, Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston
    Objectives: To examine Hedgehog signaling in cutaneous fibrosing disorders for which effective approved therapies are lacking, expand our knowledge of pathophysiology, and explore the rationale for targeted inhibition.

    Methods: Stain intensity and percentage of cells staining for Sonic hedgehog (Shh), Indian hedgehog (Ihh), Patched (Ptch), glycogen synthase kinase 3 β (GSK3-β), β-catenin, and Snail were evaluated in human skin biopsy specimens of keloid, hypertrophic scar (Hscar), scleroderma, nephrogenic systemic fibrosis (NSF), scar, and normal skin using a tissue microarray.

    Results: Ihh, but not Shh, was detected in a significantly larger proportion of cells for all case types. Read More

    Novel Insights on Understanding of Keloid Scar: Article Review.
    J Am Coll Clin Wound Spec 2015 Dec 30;7(1-3):1-7. Epub 2016 Nov 30.
    Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States.
    Keloid scar, dermal benign fibro-proliferative growth that extends outside the original wound and invades adjacent dermal tissue due to extensive production of extracellular matrix, especially collagen, which caused by over expression of cytokines and growth factors. Although many attempts were made to understand the exact pathophysiology and the molecular abnormalities, the pathogenesis of keloid scar is yet to be determined. Even though there are several treatment options for keloid scars include combination of medical and surgical therapies like combination of surgical removal followed by cryotherapy or intralesional steroid therapy, the reoccurrence rate is still high despite the present treatment. Read More

    Delayed allergic dermatitis presenting as a keloid-like reaction caused by sting from an Indo-Pacific Portuguese man-o'-war (Physalia utriculus).
    Clin Exp Dermatol 2017 Mar 2;42(2):182-184. Epub 2017 Jan 2.
    Department of Dermatology, Botucatu Medical School, São Paulo State University, São Paulo, Brazil.
    Cnidarian envenomations are common occurrences in the tropics that can affect holidaymakers. The cutaneous reactions are classified as immediate or delayed types. Delayed allergic reactions are persistently recurring dermatitis, which can occur within 1-4 weeks from the initial sting, and may last for several months. Read More

    A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study.
    Dermatol Surg 2017 Jan;43 Suppl 1:S37-S46
    Department of Plastic Surgery, Linkou Burn Center, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.
    Background: The formation of hypertrophic scaring (HSc) is an abnormal wound-healing response. In a previous study, an animal model with human scar tissue implanted into nude mice (BALB/c) has been successfully established. The effects of verapamil as well as combination therapy with verapamil and kenacort have been studied and compared. Read More

    Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars.
    Rev Assoc Med Bras (1992) 2016 Dec;62(9):862-866
    PhD Professor and Head of the Division of Plastic Surgery, FMRP-USP, Ribeirão Preto, SP, Brazil.
    Introduction: Since the 1980s, the use of autologous fat grafting has been growing in plastic surgery. Recently, this procedure has come to be used as a treatment for keloids and hypertrophic scars mainly due to the lack of satisfactory results with other techniques. So far, however, it lacks more consistent scientific evidence to recommend its use. Read More

    Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders.
    Med Hypotheses 2016 Nov 28;96:51-60. Epub 2016 Sep 28.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.
    Keloids and hypertrophic scars are fibroproliferative disorders (FPDs) of the skin that result from abnormal healing of injured or irritated skin. They can be called pathological or inflammatory scars. Common causes are trauma, burn, surgery, vaccination, skin piercing, folliculitis, acne, and herpes zoster infection. Read More

    Endothelial cell-derived endothelin-1 is involved in abnormal scar formation by dermal fibroblasts through RhoA/Rho-kinase pathway.
    Exp Dermatol 2016 Nov 28. Epub 2016 Nov 28.
    Department of Plastic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
    Hypertrophic scars and keloids are characterized by excessive dermal deposition of extracellular matrix due to fibroblast-to-myofibroblast differentiation. Endothelin-1 (ET-1) is primarily produced by vascular endothelial cells, and plays multiple roles in the wound-healing response and organ fibrogenesis. In this study, we investigated the pathophysiological significance of ET-1 and involvement of RhoA, a member of the Rho GTPases, in hypertrophic scar/keloid formation. Read More

    Comparative effect and safety of verapamil in keloid and hypertrophic scar treatment: a meta-analysis.
    Ther Clin Risk Manag 2016 9;12:1635-1641. Epub 2016 Nov 9.
    Department of Dermatology, Yanbian University Affiliated hospital, Yanji, Jilin, People's Republic of China.
    Background: Keloids and hypertrophic scars are the most common types of pathological scarring. Traditionally, keloids have been considered as a result of aberrant wound healing, involving excessive fibroblast participation that is characterized by hyalinized collagen bundles. However, the usefulness of this characterization has been questioned. Read More

    Can subphysiological cold application be utilized in excessive dermal scarring prophylaxis and treatment?: A promising hypothetical perspective.
    Med Hypotheses 2016 Dec 19;97:4-6. Epub 2016 Oct 19.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.
    Excessive dermal scarring (EDS) is a wound healing complication, characterized by protruded erythematous and inelastic 'proliferative scar tissue' which is associated with increased and prolonged inflammation process within the wound microenvironment. As inflammation plays a key role in this process, methods to contain or attenuate excessive inflammation hold promise in treatment and prophylaxis of EDS conditions. While cold exposure is notorious as the causative agent a wide array of morbidities and fatalities, its tempered use is exploited in medicine for ablative and therapeutic applications. Read More

    S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis.
    J Invest Dermatol 2016 Nov 10. Epub 2016 Nov 10.
    Laboratory for Wound Repair and Regenerative Surgery, Department of Surgery/Plastic Surgery Division, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:
    Disruption of the barrier function of skin increases transepidermal water loss and up-regulates inflammatory pathways in the epidermis. Consequently, sustained expression of proinflammatory cytokines from the epidermis is associated with dermal scarring. We found increased expression of S100A12 in the epidermis of human hypertrophic and keloid scar. Read More

    Comparing Two Methods of Cryotherapy and Intense Pulsed Light with Triamcinolone Injection in the Treatment of Keloid and Hypertrophic Scars: A Clinical Trial.
    Osong Public Health Res Perspect 2016 Oct 23;7(5):313-319. Epub 2016 Aug 23.
    Department of Dermatology, Kerman University of Medical Sciences, Kerman, Iran.
    Objectives: Keloid and hypertrophic scars are abnormal manifestations of wounds that occur following skin injuries in the form of local proliferation of fibroblasts and increased production of collagen. There are several ways to cure these scars; treatment must be selected based on the nature of the scars. In this clinical trial, two methods-cryotherapy and intense pulsed light (IPL)-are compared in the treatment of scars, and the results are presented in terms of improvement level, complications, and patient satisfaction. Read More

    Measurements of scar properties by SkinFibroMeter(®) , SkinGlossMeter(®) , and Mexameter(®) and comparison with Vancouver Scar Scale.
    Skin Res Technol 2016 Oct 30. Epub 2016 Oct 30.
    Department of Dermatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    Background: An objective measurement of scar is important for evaluating treatment outcomes. However, to date, there is no 'gold standard' for quantitative measurement of properties of hypertrophic scar. Existing objective modalities are neither portable nor easy to use. Read More

    The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management.
    Curr Pharm Des 2016 Oct 25. Epub 2016 Oct 25.
    Department of Plastic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, China.
    Cutaneous scars (particularly hypertrophic and keloid scars), always follow after a dermal injury to the skin cutaneous scars leave a negative impact on people, both physically and mentally. Comparing to other surgical treatments, patients who do not opt for or can't opt for invasion therapy are more eligible for using the topical anti-scarring agents. In this mini-review, we have researched for and collected the data between October 2005 and October 2015, in PubMed and Web of Science, and identified those agents including silicone-based products, imiquimod, corticosteroids, 5- fluorouracil, bleomycin, mitomycin, and plant extracts such as onion extract, asiaticoside, aloe vera, vitamin E, and so on. Read More

    Objective and subjective treatment evaluation of scars using optical coherence tomography, sonography, photography, and standardised questionnaires.
    Eur J Dermatol 2016 Dec;26(6):599-608
    Department of Dermatology and Allergology, University Hospital of Munich (LMU), Munich.
    Background: Currently, different types of treatments for pathological scars are available, however, to date, there is no established method of measurement to objectively assess therapeutic outcome. Treatment success is usually evaluated clinically by the physician and patient. Non-invasive imaging techniques, such as HD-OCT (high-definition optical coherence tomography), may represent a valuable diagnostic tool to objectively measure therapeutic outcome. Read More

    [Specificities in children wound healing].
    Ann Chir Plast Esthet 2016 Oct 8;61(5):341-347. Epub 2016 Jun 8.
    Chirurgie plastique reconstructrice et esthétique, hôpital Maison-Blanche, CHU de Reims, 45, rue Cognacq-Jay, 51100 Reims, France; Chirurgie pédiatrique, American Memorial Hospital, CHU de Reims, 47, rue Cognacq-Jay, 51100 Reims, France; EA 3801, université de Champagne-Ardenne, 41, rue Cognacq-Jay, 51095 Reims cedex, France. Electronic address:
    Children have specific characteristics of wound healing. The aim of this study was to describe the specific clinical characteristics of wounds healing in children and to present the current knowledge on the specific mechanisms with regard to infant age. The tissue insult or injury in fetus can heal without scar, mainly due to reduced granulation tissue associated to diminished or even no inflammatory phase, modified extracellular matrix such as the concentration of hyaluronic acid in amniotic liquid, expression and arrangement of collagen and tenascin. Read More

    Keloids: Current Therapies in Barbados.
    West Indian Med J 2016 Mar 10. Epub 2016 Mar 10.
    Faculty of Medical Sciences, The University of the West Indies, Cave Hill, St Michael, Barbados, West Indies, e-mail:
    Keloids are characterised by scar tissue overgrowth on the skin beyond the borders of the original wound following an abnormal wound healing process and tend not to regress. These disfiguring scars can cause pain, itching and inflammation for the patient leading to an emotional and psychological impact and a sub-standard quality of life. A variety of treatments using surgical and non-surgical approaches exists that have been reported to be beneficial. Read More

    Water-filtered near-infrared influences collagen synthesis of keloid-fibroblasts in contrast to normal foreskin fibroblasts.
    J Photochem Photobiol B 2016 Oct 15;163:194-202. Epub 2016 Aug 15.
    Goethe-University, Medical School, Department of Dermatology, Venereology and Allergology, Frankfurt/Main, Germany.
    Hypertrophic scar development is associated to impaired wound healing, imbalanced fibroblast proliferation and extracellular matrix synthesis. Stigmatization, physical restrictions and high recurrence rates are only some aspects that illustrate the severe influence impaired wound healing can have on patients' life. The treatment of hypertrophic scars especially keloids is still a challenge. Read More

    Evidence-Based Scar Management: How to Improve Results with Technique and Technology.
    Plast Reconstr Surg 2016 Sep;138(3 Suppl):165S-78S
    Columbus, Ohio; and Dallas, Texas From the Department of Plastic Surgery, the Ohio State University Wexner Medical Center; and Department of Plastic Surgery, the University of Texas-Southwestern Medical Center.
    Background: Scars represent the visible sequelae of trauma, injury, burn, or surgery. They may induce distress in the patient because of their aesthetically unpleasant appearance, especially if they are excessively raised, depressed, wide, or erythematous. They may also cause the patient symptoms of pain, tightness, and pruritus. Read More

    Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars.
    Int J Dermatol 2016 Nov;55(11):1255-1258
    Department of Dermatology, Universidade Federal de São Paulo (UNIFESP; Federal University of São Paulo), São Paulo, SP, Brazil.
    Background: Acne vulgaris is a chronic inflammatory disease characterized by non-inflammatory and inflammatory lesions that can cause scarring. Oral isotretinoin is the current recommended treatment for moderate and severe cases; however, there are reports of possible influences on the healing process of the skin, leading to an increase in the risk for hypertrophic scars and keloids. This hypothesis, although unproven, represents a contraindication to the treatment of acne scars during the 6-12 months after the cessation of isotretinoin. Read More

    The Role of Elastic Fibers in Scar Formation and Treatment.
    Dermatol Surg 2017 Jan;43 Suppl 1:S19-S24
    *The Ronald O. Perelman Department of Dermatology, NYU Langone Medical Center, New York, New York; †Laser & Skin Surgery Center of New York, New York, New York; ‡McDaniel Institute of Anti-Aging Research, Virginia Beach, Virginia.
    Background: Laser therapy is a continuously evolving treatment option for scars, and the underlying therapeutic mechanisms continue to be elucidated.

    Objective: To comprehensively review the literature to summarize the role of elastin in the formation scars, as well as treatment via therapeutic lasers.

    Methods: Review of the PubMED/MEDLINE database for available studies pertaining to the role of elastic fibers in scar formation and after laser-based therapy. Read More

    Surgical Outcome in Patients Taking Concomitant or Recent Intake of Oral Isotretinoin: A Multicentric Study-ISO-AIMS Study.
    J Cutan Aesthet Surg 2016 Apr-Jun;9(2):106-14
    Skinnovation Laser Clinic, New Delhi, India.
    Background: The current standard recommendation is to avoid surgical interventions in patients taking oral isotretinoin. However, this recommendation has been questioned in several recent publications.

    Aim: To document the safety of cosmetic and surgical interventions, among patients receiving or recently received oral isotretinoin. Read More

    Nodular Scleroderma Revisited: Systemic Sclerosis Presenting as Annular Keloidal Sclerotic Plaques.
    J Clin Aesthet Dermatol 2016 Jun 1;9(6):56-7. Epub 2016 Jun 1.
    The Division of Dermatology, University of California San Diego, San Diego, California;
    Background: Nodular scleroderma, also known as keloidal scleroderma, is a rare variant of systemic sclerosis.

    Purpose: The clinical features, pathologic findings and postulated pathogenesis of nodular scleroderma are discussed.

    Methods: A woman with previously undiagnosed systemic sclerosis who presented with nodular scleroderma is described. Read More

    Increased epidermal thickness and abnormal epidermal differentiation in keloid scars.
    Br J Dermatol 2017 Jan 26;176(1):116-126. Epub 2016 Nov 26.
    Department of Dermatology, VU Medical Centre, Amsterdam, the Netherlands.
    Background: The pathogenesis underlying keloid formation is still poorly understood. Research has focused mostly on dermal abnormalities, while the epidermis has not yet been studied.

    Objectives: To identify differences within the epidermis of mature keloid scars compared with normal skin and mature normotrophic and hypertrophic scars. Read More

    Patient-Reported Outcome Instruments for Surgical and Traumatic Scars: A Systematic Review of their Development, Content, and Psychometric Validation.
    Aesthetic Plast Surg 2016 Oct 29;40(5):792-800. Epub 2016 Jun 29.
    Plastic and Reconstructive Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
    Background: Patient-reported outcomes (PROs) are of growing importance in research and clinical care and may be used as primary outcomes or as compliments to traditional surgical outcomes. In assessing the impact of surgical and traumatic scars, PROs are often the most meaningful. To assess outcomes from the patient perspective, rigorously developed and validated PRO instruments are essential. Read More

    Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment.
    Dermatol Surg 2017 Jan;43 Suppl 1:S3-S18
    *Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida; †Dermatology Resident, University of Miami Miller School of Medicine, Miami, Florida; ‡Micrographic Surgery and Dermatologic Oncology, SkinCare Physicians, Chestnut Hill, Massachusetts.
    Background: Keloid and hypertrophic scars represent an aberrant response to the wound healing process. These scars are characterized by dysregulated growth with excessive collagen formation, and can be cosmetically and functionally disruptive to patients.

    Objective: Objectives are to describe the pathophysiology of keloid and hypertrophic scar, and to compare differences with the normal wound healing process. Read More

    Three-dimensional imaging for volume measurement of hypertrophic and keloid scars, reliability of a previously validated simplified technique in clinical setting.
    Skin Res Technol 2016 Nov 10;22(4):513-518. Epub 2016 Jun 10.
    Plastic Surgery, Maastricht University Medical Center, Maastricht, Limburg, The Netherlands.
    Introduction: Evidence behind many of the current treatments in hypertrophic and keloid scars remains limited. Current objective methods to assess efficacy and provide follow-up can be complex and are not easily applied in clinical setting. The aim of this study was to assess reliability of a recently validated simplified technique for volume measurement in clinical practice. Read More

    Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling.
    J Dermatol Sci 2016 Aug 4;83(2):95-105. Epub 2016 Mar 4.
    Department of Aesthetic, Plastic, and Burn Surgery, Shangdong Provincial Hospital, Shangdong University, No. 324 Jing 5 wei 7 Road, Jinan 250021, China. Electronic address:
    Background: Hypertrophic scars and keloids, characterized by over-proliferation of fibroblasts and aberrant formation of the extracellular matrix (ECM), are considered fibrotic diseases. Accumulating evidence indicates that mesenchymal stem cells (MSCs) promote scar-free wound healing and inhibit fibrotic tissue formation, making them a potentially effective therapeutic treatment for hypertrophic scars and keloids.

    Objective: To investigate the paracrine effects of bone marrow derived MSCs (BMSCs) on the biological behavior of hypertrophic scar fibroblasts (HSFs) and keloid fibroblasts (KFs). Read More

    [Verapamil in conjunction with pressure therapy in the treatment of pathologic scar due burn injury].
    Rev Med Inst Mex Seguro Soc 2016 Jul-Aug;54(4):454-7
    Unidad de Atención al Niño Quemado, Nuevo Nuevo Hospital Civil de Guadalajara "Juan I. Menchaca", Guadalajara, Jalisco, México.
    Background: Keloids and hypertrophic scars are dermal fibro-proliferative disorders unique to humans. Their treatment is a true challenge with multiple options, but not all the time with good results. Unfortunately this problem is not uncommon in patients with history of burn injury. Read More

    Advances in scar management: prevention and management of hypertrophic scars and keloids.
    Curr Opin Otolaryngol Head Neck Surg 2016 Aug;24(4):322-9
    Department of Otolaryngology - Head and Neck Surgery, University of California, Davis, Sacramento, California, USA.
    Purpose Of Review: Abnormal scarring remains a poorly understood but functional and aesthetic consequence of surgical and traumatic wounds. The purpose of this review is to describe the current state of the science behind the prevention and management of these scars.

    Recent Findings: A recent update in the International Clinical Recommendations on Scar Management provides a wealth of information on new and revised treatments for hypertrophic scars and keloids. Read More

    Interventions for acne scars.
    Cochrane Database Syst Rev 2016 Apr 3;4:CD011946. Epub 2016 Apr 3.
    Department of Dermatology, Faculty of Medicine, Cairo University, 13th Abrag Othman, Kournish el Maadi, Cairo, Egypt, 11431.
    Background: Acne scarring is a frequent complication of acne and resulting scars may negatively impact on an affected person's psychosocial and physical well-being. Although a wide range of interventions have been proposed, there is a lack of high-quality evidence on treatments for acne scars to better inform patients and their healthcare providers about the most effective and safe methods of managing this condition. This review aimed to examine treatments for atrophic and hypertrophic acne scars, but we have concentrated on facial atrophic scarring. Read More

    Diagnosis, Management, and Histopathological Characteristics of Corneal Keloid: A Case Series and Literature Review.
    Asia Pac J Ophthalmol (Phila) 2016 Sep-Oct;5(5):354-9
    From the *Cornea and Refractive Services and †Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
    Purpose: Corneal keloids are rare lesions that develop in cases of corneal insult. We describe the clinical features, subsequent management, and histopathological characteristics of 5 of our cases of corneal keloid.

    Design: This was an interventional case series. Read More

    Forehead Mass Removal by Endoscopic Approach.
    J Craniofac Surg 2016 Mar;27(2):e215-7
    Department of Plastic and Reconstructive Surgery, Sacred Heart Hospital, Hallym University Medical Center, Hallym University, Anyang, South Korea.
    Patients with forehead mass have a cosmetic problem because the forehead is an important first impression. Conventional skin approach results in visible scar even though surgeons designed the incision along the relaxed skin tension line1. Since Onishi introduced the technique for endoscopic approach in 1995, endoscopic surgery has become rapidly popular in the field of plastic surgery. Read More

    [Application of photodynamic therapy combined with compound betamethasone in treatment of hypertrophic scar].
    Zhonghua Zheng Xing Wai Ke Za Zhi 2015 Sep;31(5):343-6
    Objective: To investigate the effect of photodynamic therapy combined with compound betamethasone in the treatment of hypertrophic scar.

    Methods: 37 cases of keloid were divided into two groups, 19 cases in the treatment group, 18 cases in the control group. The patients in treatment group were treated with photodynamic therapy combined with compound betamethasone injection therapy. Read More

    Keloids and Hypertrophic Scars: A Spectrum of Clinical Challenges.
    Am J Clin Dermatol 2016 Jun;17(3):201-23
    Hampton University Skin of Color Research Institute, Hampton University, Hampton, VA, USA.
    Since their earliest description, keloids and hypertrophic scars have beleaguered patients and clinicians alike. These scars can be aesthetically disfiguring, functionally debilitating, emotionally distressing, and psychologically damaging, culminating in a significant burden for patients. Our current understanding of keloid pathophysiology has grown and continues to advance while molecular biology, genetics, and technology provide ever-deepening insight into the nature of wound healing and the pathologic perturbations thereof. Read More

    The Immunomodulatory Effects of Mesenchymal Stem Cells in Prevention or Treatment of Excessive Scars.
    Stem Cells Int 2016 29;2016:6937976. Epub 2015 Dec 29.
    Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
    Excessive scars, including keloids and hypertrophic scars, result from aberrations in the process of physiologic wound healing. An exaggerated inflammatory process is one of the main pathophysiological contributors. Scars may cause pain, and pruritis, limit joint mobility, and cause a range of cosmetic deformities that affect the patient's quality of life. Read More

    Savior of post-blepharoepicanthoplasty scarring: Novel use of a low-fluence 1064-nm Q-switched Nd:YAG laser.
    J Cosmet Laser Ther 2016 28;18(2):69-71. Epub 2016 Jan 28.
    a Department of Surgery , Singapore General Hospital , Singapore.
    Blepharoplasty with medial epicanthoplasty is popular in Asia. However, known complications include scarring, which can take the form of hypertrophic scars or keloids. Treatments for scars include pressure dressing, silicone gels, retinoic acids, radiotherapy, cryotherapy, triamcinolone injections, and surgical revision. Read More

    Central regions of keloids are severely ischaemic.
    J Plast Reconstr Aesthet Surg 2016 Feb 8;69(2):e35-41. Epub 2015 Dec 8.
    Department of Pathology, Osaka Medical College, Takatsuki, Osaka, Japan.
    We classified scars as keloids, hypertrophic scars and mature scars, and then examined the scars for differences in central and marginal vascularization. We found significant differences in localized hypoxia-induced factor-1α (HIF-1α) expression and vascular density in keloids, but no localized differences in hypertrophic or mature scars. The central areas of keloids exhibited higher HIF-1α expression and lower vascular density than marginal areas, suggesting that the former are severely ischaemic. Read More

    Pulsed dye laser versus long-pulsed Nd:YAG laser in the treatment of hypertrophic scars and keloid: A comparative randomized split-scar trial.
    J Cosmet Laser Ther 2016 Aug 8;18(4):208-12. Epub 2016 Mar 8.
    a Dermatology and Venereology Department, Faculty of Medicine -Al-Azhar University , Cairo , Egypt.
    Introduction: Keloids and hypertrophic scars are benign fibrous growths that occur after trauma or wounding of the skin and present a major therapeutic problem.

    Objective: The purpose of this study is to evaluate and compare the effectiveness of pulsed dye laser (PDL) versus Nd:YAG laser in hypertrophic scar and keloid.

    Methods: Twenty patients with hypertrophic scars and keloid were included in this prospective, randomized, split-scar study. Read More

    Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar.
    J Mol Histol 2016 Feb 7;47(1):35-45. Epub 2015 Dec 7.
    Discipline of Anatomy and Pathology, School of Medicine, University of Adelaide, Adelaide, SA, 5005, Australia.
    We have recently shown that Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) has a single high-affinity binding site for fibroblast growth factor-2 (FGF-2) and that LTBP-2 blocks FGF-2 induced cell proliferation. Both proteins showed strong co-localisation within keloid skin from a single patient. In the current study, using confocal microscopy, we have investigated the distribution of the two proteins in normal and fibrotic skin samples including normal scar tissue, hypertrophic scars and keloids from multiple patients. Read More

    Mechanism of Action, Efficacy, and Adverse Events of Calcium Antagonists in Hypertrophic Scars and Keloids: A Systematic Review.
    Dermatol Surg 2015 Dec;41(12):1343-50
    Department of Plastic, Reconstructive and Hand Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
    Background: Pathological scars often cause major cosmetic and functional consequences, which make effective treatment important. Intralesional therapies are widely used, with corticosteroid injection considered to be first choice. An emerging and promising treatment option is the calcium antagonist verapamil. Read More

    S100A8 and S100A9 Are Induced by Decreased Hydration in the Epidermis and Promote Fibroblast Activation and Fibrosis in the Dermis.
    Am J Pathol 2016 Jan 18;186(1):109-22. Epub 2015 Nov 18.
    Laboratory for Wound Repair and Regenerative Surgery, Department of Surgery, Plastic Surgery Division, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Electronic address:
    The most critical function of the epidermis is to prevent water loss and maintain skin homeostasis. Disruption of the functional skin barrier causes delayed wound healing, hypertrophic scarring, and many skin diseases. Herein, we show that reduced hydration increases the expression of S100 protein family members, S100A8/S100A9, in stratified keratinocyte culture and human ex vivo skin culture. Read More

    [Keloid scars (part I): Clinical presentation, epidemiology, histology and pathogenesis].
    Ann Chir Plast Esthet 2016 Apr 3;61(2):128-35. Epub 2015 Nov 3.
    Service de chirurgie plastique et réparatrice, hôpital Nord, AP-HM, CHU de Marseille, chemin des Bourrely, 13915 Marseille cedex 20, France.
    Keloid scars are a dysregulated response to cutaneous wound healing and are characterized by excessive deposition of collagen. Clinical and histological aspects are typical but they are often confused with hypertrophic scars. Principal pathogenesis is abnormal regulation of the collagen equilibrium because of TGFβ. Read More

    Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring.
    Adv Wound Care (New Rochelle) 2015 Nov;4(11):687-703
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology (MIB), The University of Manchester , Manchester, United Kingdom .
    Significance: Cutaneous scarring is an almost inevitable end point of adult human wound healing. It is associated with significant morbidity, both physical and psychological. Pathological scarring, including hypertrophic and keloid scars, can be particularly debilitating. Read More

    Treatment of hypertrophic scars and keloids by fractional carbon dioxide laser: a clinical, histological, and immunohistochemical study.
    Lasers Med Sci 2016 Jan;31(1):9-18
    Treatment of keloids (K) and hypertrophic scars (HTS) is challenging. A few case reports reported good results in HTS treated by fractional CO2 laser. The aim of the present study was the assessment of the clinical response as well as histological changes in K and HTS treated by fractional CO2 laser and the role of matrix metalloproteinase 9 (MMP9) in the response. Read More

    Creation of a head and neck Keloid quality of life questionnaire.
    Laryngoscope 2015 Dec 30;125(12):2672-6. Epub 2015 Sep 30.
    Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.
    Objectives: Create a head-and-neck keloid quality of life (QOL) questionnaire. Demonstrate the reliability of the keloid-specific QOL scale according to test-retest and internal consistency standards.

    Study Design: Prospective cohort study. Read More

    Evaluation of the Role of Granzyme B in Exuberant Scar Pathogenesis: An Immunohistochemical Study.
    Anal Quant Cytopathol Histpathol 2015 Aug;37(4):221-6
    Objective: To evaluate the possible role of Granzyme B (GzmB) in abnormal wound healing through its immunohistochemical expression in keloid and hypertrophic scars and to study the relationship of its expression with the clinicopathologic parameters of studied cases.

    Study Design: Using immunohistochemical techniques, GzmB was analyzed in skin biopsies of 44 patients (30 cases with abnormal scars [21 with keloid and 9 with hypertrophic scars] and 14 age- and gender-matched cases with surgical scars as a control group).

    Results: GzmB was expressed in keratinocytes in 28. Read More

    Ingenol mebutate treatment in keloids.
    BMC Res Notes 2015 Sep 22;8:466. Epub 2015 Sep 22.
    A.O.R.N. Sant'Anna e San Sebastiano Caserta, 81100, Caserta, Italy.
    Background: Ingenol-mebutate has been used for the treatment of actinic keratosis. It has been shown that ingenol-mebutate inhibits the growth of cancer cells or induces tumor cell death through pro-apoptotic effects. Keloids are benign skin tumours and are the effect of a deregulated wound-healing process in genetically predisposed patients. Read More

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