4,409 results match your criteria Keloid and Hypertrophic Scar


Detection of Angiotensin II and AT Receptor Concentrations in Keloid and Hypertrophic Scar.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):36-39. Epub 2018 Oct 1.

Drs. Niazi, Hooshyar, Doroodgar, and Niazi are with the Department of Plastic and Reconstructive Surgery at Modarres Hospital School of Medicine at Shahid Beheshti University of Medical Sciences in Tehran, Iran.

Keloid and hypertrophic scars (HTS) are formed by excessive collagen formation. Angiotensin II, through the AT receptor, plays an important role in extracellular matrix production. However, less is known about angiotensin II and AT receptor concentrations in HTS and keloid tissues. Read More

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October 2018
1 Read

Single-fraction radiation: A promising adjuvant therapy to prevent keloid recurrence.

J Cancer Res Ther 2018 Oct-Dec;14(6):1251-1255

Department of Radiation Oncology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.

Introduction: Keloids are characterized by collection of atypical fibroblasts with excessive deposition of extracellular matrix components. Keloids are prone to high recurrence (50%-80%) with unimodality treatment. Radiation is a promising approach among the adjuvant modalities in vogue though consensus is lacking on dose-fractionation schedule. Read More

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November 2018
1 Read

The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review.

Scars Burn Heal 2018 Jan-Dec;4:2059513118808773. Epub 2018 Nov 18.

Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.

Introduction: Autologous platelet-based concentrates represent increasingly popular adjuncts to a variety of medical, surgical and aesthetic interventions. Their beneficial potential rests on the ability to deliver a high concentration of growth factors to the target tissues. There are currently no reports in the literature appraising the evidence behind the use of platelet-rich plasma (PRP) in scar management. Read More

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November 2018

A microRNA-29 mimic (remlarsen) represses extracellular matrix expression and fibroplasia in the skin.

J Invest Dermatol 2018 Nov 22. Epub 2018 Nov 22.

miRagen Therapeutics, Inc. Boulder, CO.

MicroRNA-29 negatively regulates fibrosis, and miR-29 is downregulated in multiple fibrotic organs and tissues, including in the skin. miR-29 mimics prevent pulmonary fibrosis in mouse models but have not previously been tested in the skin. This study aimed to identify pharmacodynamic (PD) biomarkers of miR-29 in mouse skin, to translate those biomarkers across multiple species and to assess the PD activity of a miR-29b mimic (remlarsen) in a clinical trial. Read More

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November 2018
2 Reads

A Role for the E3 Ubiquitin Ligase NEDD4 in Keloid Pathogenesis.

J Invest Dermatol 2018 Nov 21. Epub 2018 Nov 21.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

The molecular pathomechanisms that drive keloid formation are only partially understood. Genetic studies have provided evidence for a genetic predisposition to keloid formation, and a keloid risk allele has been reported in the gene locus for the E3 ubiquitin ligase NEDD4. Fujita et al. Read More

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November 2018

Epithelial-mesenchymal transition in keloid tissue.

Arch Plast Surg 2018 Nov 15;45(6):600-601. Epub 2018 Nov 15.

Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul, Korea.

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November 2018

Two Cases of Sclerotic Fibroma of the Skin that Mimicked Keloids Clinically.

J Nippon Med Sch 2018 ;85(5):283-286

Department of Plastic, Reconstructive & Aesthetic Surgery, Nippon Medical School.

Sclerotic fibromas of the skin (SFSs) have a very characteristic histology but the clinical signs are non-specific. Consequently, it is extremely difficult to make a diagnosis of SFS on the basis of the clinical findings only. We report here two cases of SFS arising on the right scapular region and the right lower leg, respectively. Read More

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January 2018
1 Read

Adjuvant Radiotherapy After Keloid Excision: Preliminary Experience in Taiwan.

Ann Plast Surg 2018 Nov 17. Epub 2018 Nov 17.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo, Japan.

Background: Surgical excision with adjuvant radiotherapy has gained attention as an effective treatment of keloid. The Asian population is challenged with a high incidence of keloid occurrence with a specific genetic predominance. The annual reported incidence of new keloid cases in Taiwan is around 30,000, but the disease control rate and effectiveness by means of surgical excision with adjuvant radiotherapy is not yet clear. Read More

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November 2018

Recurrent, Activating Variants in the Receptor Tyrosine Kinase DDR2 Cause Warburg-Cinotti Syndrome.

Am J Hum Genet 2018 Nov 8. Epub 2018 Nov 8.

Department of Ophthalmology, Haukeland University Hospital, N-5021 Bergen, Norway; Department of Medical Genetics, Haukeland University Hospital, N-5021 Bergen, Norway; Department of Clinical Medicine, University of Bergen, N-5021 Bergen, Norway.

We have investigated a distinct disorder with progressive corneal neovascularization, keloid formation, chronic skin ulcers, wasting of subcutaneous tissue, flexion contractures of the fingers, and acro-osteolysis. In six affected individuals from four families, we found one of two recurrent variants in discoidin domain receptor tyrosine kinase 2 (DDR2): c.1829T>C (p. Read More

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November 2018
4 Reads

Treatment of keloid scars with intralesional triamcinolone and 5-fluorouracil injections - a randomized controlled trial.

J Plast Reconstr Aesthet Surg 2018 Jun 25. Epub 2018 Jun 25.

Department of Musculoskeletal Surgery and Diseases, Tampere University Hospital, Tampere, Finland.

Keloids have high recurrence rates. Current first-line therapy is triamcinolone (TAC) injection, but it has been suggested that approximately 50% of keloids are steroid resistant. We compared the efficacy of intralesional 5-fluorouracil (5-FU) and triamcinalone injections in a double-blind randomized controlled trial. Read More

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June 2018
2 Reads

Keloid negatively affects body image.

Burns 2018 Nov 11. Epub 2018 Nov 11.

Universidade Federal de São Paulo (UNIFESP/EPM) - Plastic Surgery Division, São Paulo, Brazil.

Background/objectives: Keloid is a healing disorder that occurs exclusively in humans. This pathology is considered a benign cicatricial neoplasm, whose physiopathogenesis has not yet completely clarified. Its disfiguring appearance often could potentially cause a disturbance in the patient regarding his/her body image. Read More

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November 2018
1 Read

Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study.

Dermatol Ther 2018 Nov 13:e12781. Epub 2018 Nov 13.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Cutaneous injury can ignite excessive fibroproliferative growth that results in keloid formation. Keloids are associated with significant morbidity related to disfigurement and/or symptoms (e.g. Read More

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November 2018
5 Reads

Sensory perception and nerve fibre innervation in patients with keloid scars: an investigative study.

Eur J Dermatol 2018 Nov 8. Epub 2018 Nov 8.

Department of Anesthesiology, Unit of Pain Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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November 2018
6 Reads

Combined Non-Ablative Laser and Microfat Grafting for Burn Scar Treatment.

Aesthet Surg J 2018 Oct 25. Epub 2018 Oct 25.

ONEP Plastic Surgery Science Institute, Istanbul, Turkey.

Background: Burn scar treatment persists as an unsolved problem, with thousands of affected patients disfigured for life.

Objectives: We present our experience with the use of combined treatments for patients with burn scars.

Methods: This is a case series report of the senior author's experience over the course of 8 years using the combined treatments of Fraxel Restore (fractional laser) and microfat graft injection for 288 patients with burn scars. Read More

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October 2018
2 Reads

Development of Individualized Induced Pluripotent Stem Cells From Fibroblasts of Keloid Lesions in Patients.

Transplant Proc 2018 Nov 11;50(9):2868-2871. Epub 2018 Apr 11.

Research Center of Stem Cell and Regenerative Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China; Department of Dermatology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. Electronic address:

Objective: Presently, interesting research related to induced pluripotent stem cells (iPSCs) is emerging. However, the development of new therapies and techniques for treatment of refractory diseases is still required in dermatology. We are exploring novel methods to provide stem cell therapy and elucidate research mechanisms underlying troublesome diseases by reprogramming iPSCs from the fibroblasts of keloid lesions from patients in vitro. Read More

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November 2018
4 Reads

A parasternal intercostal perforator flap for esthetic reconstruction after complete chest keloid resection: A retrospective observational cohort study.

J Cosmet Dermatol 2018 Nov 4. Epub 2018 Nov 4.

Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, CAMS and PUMC, Beijing, China.

Objective: To report on the outcome of 35 patients with chest keloids who were treated with intercostal perforator flap surgery plus local radiotherapy at our hospital.

Methods: We retrospectively analyzed the data of patients with chest keloid who under surgical resection at the Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing, China between March 2014 and July 2017. We retrieved patient demographic data, donor site position, the perforator pedicle, flap size, angle of flap rotation, complications, and recurrences from the medical records. Read More

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November 2018
5 Reads

A pilot study comparing two sites for incision during pacemaker implantation and their influence on the scar.

Indian Heart J 2018 Sep - Oct;70(5):704-708. Epub 2018 May 9.

K.J. Somaiya Medical College and Research Centre, Mumbai, India; Cosmetic Plastic Surgery & Laser Superspecialities, Mumbai, India; Cardiac Safety Services, Quintiles, Mumbai, India; Arrhythmia Associates, Mumbai, India. Electronic address:

Objective: There are two most common incisions that are used during most pacemaker implantation procedures, with the first type of incision being inferior and parallel to the clavicle (Group C) and the second type of incision along the deltopectoral groove (Group D). We evaluated the scars resulting from the two types of incision to objectively evaluate the degree of superiority in cosmetic outcomes, between these two types of incisions.

Methods: Seventy-six patients who underwent left pre-pectoral pacemaker insertion were evaluated, close to 6 months after the date of the pacemaker implantation, using a simple scoring system based on atrophy, contour and colour of the scar. Read More

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May 2018
2 Reads

Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate.

J Zhejiang Univ Sci B 2018 Nov.;19(11):853-862

Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing 100730, China.

Objective: Keloids are exuberant cutaneous scars that form due to abnormal growth of fibrous tissue following an injury. The primary aim of this study was to assess the efficacy and mechanism of hyperbaric oxygen therapy (HBOT) to reduce the keloid recurrence rate after surgical excision and radiotherapy.

Methods: (1) A total of 240 patients were randomly divided into two groups. Read More

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November 2018
6 Reads

Patient-reported outcomes for keloids: a systematic review.

G Ital Dermatol Venereol 2018 Oct 29. Epub 2018 Oct 29.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA -

Introduction: Keloids are exuberant responses to cutaneous wound healing. Many research studies utilize keloid recurrence, scar thickness, and objective physician-reported data as outcome measures. Patients may have different perceptions and evaluations of treatment success from physicians, however. Read More

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October 2018
3 Reads

MiR-203 regulates keloid fibroblast proliferation, invasion, and extracellular matrix expression by targeting EGR1 and FGF2.

Biomed Pharmacother 2018 Dec 3;108:1282-1288. Epub 2018 Oct 3.

Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, 130021, China. Electronic address:

Keloid is a fibrous benign tumor of the skin caused by increased fibroblast proliferation and overproduction of extracellular matrix (ECM) in the dermis. Several miRNAs exhibit critical roles in regulating keloid development. This is study aimed to investigate the effects and mechanisms of miR-203 in keloid fibroblasts. Read More

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December 2018
6 Reads

Reconstructed human keloid models show heterogeneity within keloid scars.

Arch Dermatol Res 2018 Dec 28;310(10):815-826. Epub 2018 Oct 28.

Department of Molecular Cell Biology and Immunology, O|2 Lab Building, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Keloid scars are often described as having an actively growing peripheral margin with a regressing centre. The aim of this study was to examine the possible heterogeneity within keloids and the involvement of different regions within and around keloid scars in the pathogenesis, using an in vitro keloid scar model. In vitro skin models were constructed from keratinocytes and fibroblasts from normal skin and different regions within and around keloid scars: periphery, centre, and (adjacent) surrounding-normal-skin regions. Read More

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December 2018

[Effects of N-(4-hydroxyphenyl) retinamide lipid microbubble combined with ultrasound on human keloid fibroblasts].

Zhonghua Shao Shang Za Zhi 2018 Oct;34(10):683-689

Department of Dermatology, Yanbian University Hospital, Yanji 133000, China.

To explore the effects of N-(4-hydroxyphenyl) retinamide (4HPR), 4HPR liposome (4HPR-L), and 4HPR lipid microbubble (4HPR-LM) combined with ultrasound on proliferation, apoptosis, and cell cycle of human keloid fibroblasts (Fbs). (1) 4HPR-L and 4HPR-LM were prepared by hydration ultrasonic method. The appearance morphology, particle size distribution, Zeta potential, loading drug concentration, encapsulation efficiency, and drug loading rate of 4HPR-L were investigated by high performance liquid chromatography, dynamic light scattering, and transmission electron microscope. Read More

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October 2018
5 Reads

Efficacy of 5-aminolevulinic acid-based photodynamic therapy against keloid compromised by downregulation of SIRT1-SIRT3-SOD2-mROS dependent autophagy pathway.

Redox Biol 2018 Oct 17;20:195-203. Epub 2018 Oct 17.

Department of Plastic and Reconstructive Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, People's Republic of China.

Keloids exhibit cancer-like properties without spontaneous regression and usually recur post excision. Although photodynamic therapy (PDT) is a promising treatment, details of the mechanisms remain to be elucidated. In this study, we investigated mechanisms involved in 5-Aminolevulinic Acid (5-ALA)-based PDT against keloid. Read More

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October 2018

Resveratrol Activated Sonic Hedgehog Signaling to Enhance Viability of NIH3T3 Cells in Vitro via Regulation of Sirt1.

Cell Physiol Biochem 2018 24;50(4):1346-1360. Epub 2018 Oct 24.

Background/aims: Injuries of the brain and spinal cord result in the formation of glial (reactive gliosis) and fibrotic (formed by fibroblasts) scars. Recent studies have shown that the fibrotic scar was much more important for hindering regeneration after brain or spinal cord injury than the astrocytic scar. However, it has been given much less attention for effects and mechanism of fibroblasts during formation of the fibrotic scar. Read More

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November 2018
2 Reads

Increased Cthrc1 Activates Normal Fibroblasts and Suppresses Keloid Fibroblasts by Inhibiting TGF-β/Smad Signal Pathway and Modulating YAP Subcellular Location.

Curr Med Sci 2018 Oct 20;38(5):894-902. Epub 2018 Oct 20.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Keloid may induce severe impairment of life quality for the patients, although keloid is a cutaneous benign tumor. Collagen triple helix repeat containing protein 1 (Cthrc1) was identified as a novel gene that was originally found in adventitial fibroblasts after arterial injury. To address the role of Cthrc1 in keloid, the expression level of Cthrc1 was assessed in normal skin and keloid tissue, as well as in normal fibroblasts (NFs) and keloid fibroblasts (KFs) by using quantitative PCR, Western blotting and immunohistochemical analysis. Read More

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October 2018

Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial.

Burns 2018 Oct 16. Epub 2018 Oct 16.

Jinnah Burn and Reconstructive Surgery Center, Allama Iqbal Medical College, Lahore, Pakistan.

The treatment of keloid and hypertrophic scar is challenging with no universally accepted mode for permanent ablation. Conventional therapies yield unpredictable results, significant complications and require elaborate hardware.

Objective: The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars. Read More

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October 2018
4 Reads

Gene Expression of Neurotrophins and Their Receptors in Keloids.

Ann Plast Surg 2018 Dec;81(6):646-652

From the Division of Plastic Surgery, Department of Surgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

The aim of this study was to assess gene expression of neurotrophins and their receptors in keloids. Skin samples of normal skin and keloids were obtained from patients in the control (n = 12) and keloid (n = 12) groups, respectively. Ribonucleic acid was extracted from the skin specimens, purified, evaluated by spectrophotometry, and used to synthesize complementary DNA. Read More

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December 2018
9 Reads

Minimally invasive video-assisted thyroidectomy: a critical analysis of long-term cosmetic results using a validated tool.

Ann R Coll Surg Engl 2018 Oct 16:1-6. Epub 2018 Oct 16.

Brandenburg Medical School, Department of Surgery, University Hospital, Brandenburg/Havel , Brandenburg , Germany.

Introduction: Since its first publication in 1997, minimally invasive video-assisted thyroidectomy (MIVAT) has developed into the predominant minimally invasive surgery of the thyroid. A major advantage over conventional thyroid surgery is the superior cosmetic result. However, there are still few data comparing the long-term cosmetic results of the two methods. Read More

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October 2018

Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis.

Chem Sci 2018 Aug 20;9(30):6340-6347. Epub 2018 Jun 20.

School of Chemical and Biomedical Engineering , Nanyang Technological University , 637457 Singapore . Email:

Development of molecular probes for the detection of reactive oxygen and nitrogen species (RONS) is important for the pathology and diagnosis of diseases. Although an abnormally high RONS level has been identified in keloids - a benign dermal tumour developed after lesion, the ability of employing RONS probes for keloid detection has not yet been exploited. Herein, we report two near-infrared (NIR) fluorescent probes ( and ) that can specifically distinguish keloid fibroblasts from normal dermal fibroblasts. Read More

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August 2018
8 Reads

[Mutations in A((8)) and A((9)) loci of exon 8 of retinoblastoma protein-interacting zinc finger gene of keloid patients].

Zhonghua Shao Shang Za Zhi 2018 Sep;34(9):643-647

Department of Plastic Surgery, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.

To study the situation of the mutations in the A((8)) and A((9)) loci of exon 8 of retinoblastoma protein-interacting zinc finger gene (RIZ) of keloid patients. From January 2003 to December 2007, 19 outpatient and hospitalized keloid patients of our hospital were conforming to the inclusion criteria. Both 3-5 g keloid tissue and 3 mL peripheral venous blood were collected from each patient to extract their genomic DNA, and the concentration was determined. Read More

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September 2018
7 Reads

NEDD4 Is Involved in Inflammation Development during Keloid Formation.

J Invest Dermatol 2018 Sep 28. Epub 2018 Sep 28.

Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. Electronic address:

Keloids mark a chronic inflammatory disease characterized by a fibroproliferative disorder of the skin. A genome-wide association study showed that single-nucleotide polymorphism rs8032158 in the neural precursor cell-expressed NEDD4 gene, which has six protein-coding transcript variants (TVs), is genetically linked to keloids. Here, we show that the high frequency of risk allele C in rs8032158 in keloid patients is associated with a selectively higher expression of TV3 of NEDD4 to activate the NF-κB pathway. Read More

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September 2018
3 Reads

Laser-Assisted Drug Delivery.

Actas Dermosifiliogr 2018 Sep 25. Epub 2018 Sep 25.

Unidad de Láser, Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

Absorption of topical products through the epidermis is limited by the skin's barrier function. Numerous techniques and agents such as microneedling, dermabrasion, radiofrequency, and lasers have been used to increase penetration within an approach known as transdermal drug delivery. One of these techniques is laser-assisted drug delivery (LADD), which often uses ablative fractional lasers (CO or erbium:YAG lasers) because of their capacity to produce microscopic ablated channels. Read More

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September 2018
7 Reads

Gallic acid inhibits fibroblast growth and migration in keloids through the AKT/ERK signaling pathway.

Acta Biochim Biophys Sin (Shanghai) 2018 Nov;50(11):1114-1120

Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Keloids are a fibroproliferative disorder of the skin resulted from abnormal healing of injured or irritated skin and are characterized by the ability to spread beyond the original boundary of the wound. Here, we tested the effect of gallic acid (GA), a plant polyphenol with selective growth inhibitory effects in cancer, on the proliferation and invasion of keloid fibroblasts (KFs) isolated from patients undergoing surgery. GA inhibited KF proliferation, migration, and invasion in parallel with the downregulation of matrix metalloproteinase-1 and -3 and upregulation of tissue inhibitors of metalloproteinase-1. Read More

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November 2018

The role and regulation of TMEM2 (transmembrane protein 2) in HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/ KIAA1199/CEMIP)-mediated HA depolymerization in human skin fibroblasts.

Biochem Biophys Res Commun 2018 Oct 18;505(1):74-80. Epub 2018 Sep 18.

Department of Cosmetic Health Science, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan. Electronic address:

We have previously reported that HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/KIAA1199/CEMIP) is a specific HA-binding protein that is essential for HA depolymerization in skin and synovial fibroblasts. HA is incorporated into cells in the presence of HYBID and clathrin, degraded in endosomes, and excreted into the extracellular space. However, it is not yet clear whether HYBID itself catalytically cleaves HA. Read More

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October 2018

Wnt2 knock down by RNAi inhibits the proliferation of in vitro-cultured human keloid fibroblasts.

Medicine (Baltimore) 2018 Sep;97(37):e12167

Department of Plastic Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.

To study the effect of knocking down wingless-related MMTV integration site 2 (Wnt2) expression by RNAi on the growth and signaling pathways of ex vitro-cultured keloid fibroblasts (KFB).Human KFB were isolated from 10 keloid patient specimens. The KFB cells were then transfected with 4 pairs of small interfering RNA (siRNA) targeting human Wnt2, respectively. Read More

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September 2018
4 Reads

Arm Contouring After Massive Weight Loss: Liposuction-Assisted Brachioplasty Versus Standard Technique.

J Cutan Aesthet Surg 2018 Apr-Jun;11(2):73-78

Department of Plastic and Reconstructive Surgery, University of Rome "Tor Vergata", Rome, Italy.

Massive weight loss (MWL) brachioplasty is frequently requested for the improvement of the appearance and function of arms. Despite its diffusion, this procedure can be associated with significant complications. Liposuction-assisted brachioplasty (LAB) preserves the vascular, nervous, and lymphatic network and reduces the incidence of postoperative complications. Read More

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September 2018
4 Reads

Keloid formation after pediatric male genital surgeries: an uncommon and difficult problem to manage.

J Pediatr Urol 2018 Aug 8. Epub 2018 Aug 8.

Division of Urology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada; Department of Surgery, Division of Urology, Sidra Medical and Research Center, Doha, Qatar.

Introduction: Penile and genital keloids are uncommon despite frequent surgeries in the genital area. Keloid scar pathogenesis is not well understood, and a uniform effective therapeutic regimen for keloids has not yet been established. In the present study, the clinical features and subsequent management in cases of severe keloid formation after pediatric genital surgery are described. Read More

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Epidermolysis Bullosa Patients' Perception of Surgical Wound and Scar Healing.

Dermatol Surg 2018 Sep 10. Epub 2018 Sep 10.

Department of Dermatology, St. George Hospital, Sydney, Australia.

Background: There is limited evidence to suggest patients with epidermolysis bullosa (EB) have more postoperative wound complications than the general population. Despite this, the authors have noted reluctance among some surgeons to operate on these patients.

Objective: A cross-sectional study was designed to investigate postoperative wound and scar healing outcomes in patients with EB. Read More

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September 2018
1 Read

Annular scaly plaque confined to presternal keloid treated with intralesional injections.

Indian J Dermatol Venereol Leprol 2018 Sep 6. Epub 2018 Sep 6.

Department of Dermatology and Venereology, AIIMS, New Delhi, India.

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September 2018
3 Reads
1.320 Impact Factor

Laser Ablation of the Recipient Area With Platelet-Rich Plasma-Enriched Epidermal Suspension Transplant in Vitiligo Surgery: A Pilot Study.

Dermatol Surg 2018 Aug 27. Epub 2018 Aug 27.

All authors are affiliated with the Department of Dermatology, Aesthetic Surgery, and Intervention Dermatology, Aura Skin Institute, Chandigarh, India.

Background: Noncultured epidermal cell suspension transplantation is a very popular surgical modality for treating vitiligo. However, the procedure can be modified to improve results.

Objective: To study the extent of repigmentation with noncultured trypsinized fragmented epidermal suspension using platelet-rich plasma (PRP) as a suspending agent and pixel erbium yttrium aluminium garnet laser for ablation of recipient area in patients with stable vitiligo. Read More

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August 2018
2 Reads

A Myxoid Fibrotic Reaction Pattern is Associated with Metastatic Risk in Cutaneous Squamous Cell Carcinoma.

Acta Derm Venereol 2018 Sep 3. Epub 2018 Sep 3.

Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Universitat Autònoma de Barcelona, ES-08003 Barcelona, Spain.

Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carcinomas). Read More

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September 2018
6 Reads

Current and upcoming therapies to modulate skin scarring and fibrosis.

Adv Drug Deliv Rev 2018 Aug 30. Epub 2018 Aug 30.

Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Biomedical Sciences Building, National University of Ireland Galway (NUI, Galway), Galway, Ireland; Science Foundation Ireland (SFI), Centre for Research in Medical Devices (CÚRAM), Biomedical Sciences Building, National University of Ireland Galway (NUI, Galway), Galway, Ireland. Electronic address:

Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response that invariably ends in the formation of scar at the wounded dermal area. Read More

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August 2018
20 Reads

Management of epidermal cysts arising from scar tissues: A retrospective clinical study.

Medicine (Baltimore) 2018 Aug;97(35):e12188

Department of Plastic and Reconstructive Surgery, Konyang University Hospital, University of Konyang College of Medicine, Myunggok Medical Research Center, Daejeon.

Few reports have described epidermal cysts (ECs) arising from scar tissues, and the standard course of treatment has not been established. We aimed to report the findings of a Korean patient series with ECs arising from scar tissues, to describe patient management in the context of previous publications, and to present a simple algorithm for managing ECs arising from scar tissues.We managed 6 patients with ECs arising from scar tissues, and retrospectively reviewed their demographic and clinical data. Read More

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August 2018
4 Reads

Incidence of and Risk Factors for Cutaneous Scarring after Herpes Zoster.

Am J Clin Dermatol 2018 Dec;19(6):893-897

Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgium.

Background: About 20% of children have cutaneous scars following chickenpox. In contrast, skin scars are not often reported after herpes zoster (HZ). Risk factors for post-HZ scarring remain undetermined. Read More

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December 2018
2 Reads

High in situ mRNA levels of IL-22, TFG-β, and ARG-1 in keloid scars.

Immunobiology 2018 Dec 20;223(12):812-817. Epub 2018 Aug 20.

Federal University of Triângulo Mineiro (UFTM) ICBN and CEFORES, Uberaba, MG, Brazil. Electronic address:

Keloid scars are currently considered a chronic inflammatory process and no longer a benign skin tumor. Keloids are defined as highly inflamed, hyperproliferative pathological scars. Growth factors and cytokines have important functions in the keloid inflammatory etiopathogenesis. Read More

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December 2018
3.040 Impact Factor

Exuberant keloid scar associated with skin neoplasia.

Rev Assoc Med Bras (1992) 2018 04;64(4):315-317

Medical Academic at the Álvaro Alvim University Hospital/HEAA - Campos dos Goytacazes/RJ. Work performed at the Dermatology Department of the Álvaro Álvim University Hospital/HEAA, located at Rua Barão da Lagoa Dourada, 409, Campos dos Goytacazes, Rio de Janeiro.

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April 2018
1 Read

[Effectiveness of internal mammary artery perforator propeller flap repair combined with radiotherapy for chest keloid in female patients].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 09;32(9):1196-1200

Department of Plastic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To investigate the effectiveness of internal mammary artery perforator (IMAP) propeller flap repair combined with radiotherapy for chest keloid in female patients.

Methods: Between January 2015 and December 2016, 15 female patients with chest keloids were treated, aged 28-75 years (mean, 45.2 years). Read More

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September 2018
2 Reads

Abdominal Fat Graft for Sellar Reconstruction: Retrospective Outcomes Review and Technical Note.

Oper Neurosurg (Hagerstown) 2018 Aug 16. Epub 2018 Aug 16.

Department of Neurological Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: The transsphenoidal approach is the standard of care for the treatment of pituitary adenomas and is increasingly employed for many anterior skull base tumors. Persistent postoperative cerebrospinal fluid (CSF) leaks can result in significant complications.

Objective: To analyze our series of patients undergoing abdominal fat graft repair of the sellar floor defect following transsphenoidal surgery, describe and investigate our current, routine technique, and review contemporary and past methods of skull base repair. Read More

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Efficacy of Autologous Platelet Concentrates as Adjuvant Therapy to Surgical Excision in the Treatment of Keloid Scars Refractory to Conventional Treatments: A Pilot Prospective Study.

Ann Plast Surg 2018 Dec;81(6):741

The 16th DepartmentPlastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical College Beijing, China

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December 2018
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Prevention of Earlobe Keloid Recurrence After Excision: Assessment of the Value of Presurgical Injection of Triamcinolone.

J Craniofac Surg 2018 Oct;29(7):e673-e675

Department of Facial Surgery, National Hospital, Abuja.

The ear is commonly involved in keloid formation, being often pierced. This study estimates the value of pre-excision triamcinolone injection of earlobe keloid, by comparing recurrence rates in patients who only received postexcision triamcinolone injection to those who had it administered before and after excision.The prospective intervention study involved 18 keloid lesions in as many consenting patients who presented with pedunculated earlobe keloid from January 2005 to January 2007. Read More

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October 2018
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