919 results match your criteria Keloid and Hypertrophic Scar


Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: A randomized controlled trial.

Burns 2018 Jun 6. Epub 2018 Jun 6.

Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Keloids and hypertrophic scars are due to overgrowth of dermal collagen following trauma to the skin that usually cause major physical, psychological and cosmetic problems.

Methods: In this randomized controlled trial, with a paired design, 50 patients with 2 or more keloids were included. In the control group (50 lesions), intralesional triamcinolone acetonide (40mg/mL) was injected at three-week intervals for a total of 18weeks. Read More

View Article
June 2018
1 Read

Novel Stereoscopic Optical System for Objectively Measuring Above-Surface Scar Volume-First-Time Quantification of Responses to Various Treatment Modalities.

Dermatol Surg 2018 Jun;44(6):848-854

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Current approaches use subjective semiquantitative or cumbersome objective methodologies to assess physical characteristics of hypertrophic and keloid scars.

Objective: This pilot study aimed to evaluate the accuracy and feasibility of a new stereoscopic optical and high-resolution 3-dimensional imaging system, for objectively measuring changes in above-surface scar volume after various interventions.

Methods: Feasibility and accuracy were assessed by monitoring the above-surface scar volume of 5 scars in 2 patients for 5 successive months. Read More

View Article

Intralesional cryotherapy for hypertrophic scars and keloids: a review.

Scars Burn Heal 2017 Jan-Dec;3:2059513117702162. Epub 2017 Apr 17.

School of Medicine, Queen Mary University London, UK.

Introduction: Hypertrophic and keloid scarring remain notoriously troublesome for patients to tolerate and frustratingly difficult for clinicians to treat. Many different treatment modalities exist, signifying the failure of any method to achieve consistently excellent results. Intralesional cryotherapy is a relatively recent development that uses a double lumen needle, placed through the core of a keloid or hypertrophic scar, to deliver nitrogen vapour, which freezes the scar from its core, outwards. Read More

View Article
April 2017
1 Read

Autologous fat grafting in keloids and hypertrophic scars: a review.

Scars Burn Heal 2017 Jan-Dec;3:2059513117700157. Epub 2017 Apr 6.

Department of Surgery, School of Clinical Science at Monash Health, Monash University, Monash Medical Centre, Victoria, Australia.

Keloid and hypertrophic scars are unique human dermal fibroproliferative disorders of the injured skin and are associated with pain, itch and can cause functional limitations. A number of genetic, systemic and local factors have been identified in the formation of keloids and hypertrophic scars. Studies have shown that adipose-derived stem cells have angiogenic and antiapoptotic properties which has effects on wound healing, soft-tissue restoration and scar remodelling, and thus may have a role in managing keloid scaring. Read More

View Article

Human recombinant epidermal growth factor in skin lesions: 77 cases in EPItelizando project.

J Dermatolog Treat 2018 May 10:1-6. Epub 2018 May 10.

a Centro Médico Teknon , Barcelona , Spain.

Objective: To analyze compounded recombinant human epidermal growth factor (rhEGF) effectiveness on skin lesions through a case series.

Design: Multicentric series of skin lesions treated with topical rhEGF. Site: Patients from 56 different health professionals, three different countries, and two recruitment years. Read More

View Article
May 2018
10 Reads

Corneal fibroma: An uncommon stromal tumor.

Indian J Ophthalmol 2018 05;66(5):699-701

Mehta Eye Clinic, Ghatkopar, Mumbai, India.

A 56-year-old male patient presented with a slow-growing, elevated, smooth, white corneal mass. The mass was excised by performing an alcohol-assisted keratoepitheliectomy and sent for histopathological examination. Subepithelially, closely packed spindle cells in "feather-stitched" or storiform pattern were seen. Read More

View Article
May 2018
1 Read

Centella asiatica (Centellicum®) facilitates the regular healing of surgical scars in subjects at high risk of keloids.

Minerva Chir 2018 Apr;73(2):151-156

IRVINE3 Labs, Chieti-Pescara University, Chieti, Italy.

Background: Formation of scars after surgical incisions requires the proper appositions of elements contributing to the scarring process. The structural rebuilding of damaged tissues is essential in producing a linear scar. The excess of blood, foreign particles, exuberant sutures, necrotic tissue, possible infective agents, as well as the ongoing inflammatory process may produce a non-linear, sometimes painful keloidal scar. Read More

View Article
April 2018
5 Reads

Mechanical forces in skin disorders.

J Dermatol Sci 2018 Jun 8;90(3):232-240. Epub 2018 Mar 8.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; International Research Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Mechanical forces are known to regulate homeostasis of the skin and play a role in the pathogenesis of skin diseases. The epidermis consists of keratinocytes that are tightly adhered to each other by cell junctions. Defects in keratins or desmosomal/hemidesmosomal proteins lead to the attenuation of mechanical strength and formation of intraepidermal blisters in the case of epidermolysis bullosa simplex. Read More

View Article
June 2018
1 Read

Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids.

Int J Mol Sci 2018 Mar 2;19(3). Epub 2018 Mar 2.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus, these significantly affect patients' quality of life. There have been many studies on hypertrophic scars and keloids; but the mechanisms underlying scar formation have not yet been well established, and prophylactic and treatment strategies remain unsatisfactory. Read More

View Article
March 2018
2 Reads

Characterization of In Vitro Reconstructed Human Normotrophic, Hypertrophic, and Keloid Scar Models.

Tissue Eng Part C Methods 2018 Apr 2;24(4):242-253. Epub 2018 Apr 2.

1 Department of Dermatology, VU Medical Centre (VUMC) , Amsterdam, The Netherlands .

To understand scar pathology, develop new drugs, and provide a platform for personalized medicine, physiologically relevant human scar models are required, which are characteristic of different scar pathologies. Hypertrophic scars and keloids are two types of abnormal scar resulting from unknown abnormalities in the wound healing process. While they display different clinical behavior, differentiation between the two can be difficult-which in turn means that it is difficult to develop optimal therapeutic strategies. Read More

View Article
April 2018
10 Reads

Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study.

Int Wound J 2018 Feb 21. Epub 2018 Feb 21.

Wound Healing and Cytoprotection Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba.

Hypertrophic scars (HTS) and keloids are forms of aberrant cutaneous healing with excessive extracellular matrix (ECM) deposition. Current therapies still fall short and cause undesired effects. We aimed to thoroughly evaluate the ability of growth hormone releasing peptide 6 (GHRP6) to both prevent and reverse cutaneous fibrosis and to acquire the earliest proteome data supporting GHRP6's acute impact on aesthetic wound healing. Read More

View Article
February 2018
8 Reads

The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review.

Dermatol Surg 2018 Feb;44(2):149-157

Department of Dermatology, University of California at Davis, Sacramento, California.

Background: Keloids and hypertrophic scars are conditions of pathologic scarring characterized by fibroblast hyperproliferation and excess collagen deposition. These conditions significantly impact patients by causing psychosocial, functional, and aesthetic distress. Current treatment modalities have limitations. Read More

View Article
February 2018
3 Reads

A new treatment of hypertrophic and keloid scars with combined triamcinolone and verapamil: a retrospective study.

Eur J Plast Surg 2018 8;41(1):69-80. Epub 2017 Jun 8.

1Department of Plastic Surgery, Maastricht University Medical Center, P Debyelaan 25, 6229HX Maastricht, The Netherlands.

Background: Since the management of keloid and hypertrophic scars still remains a difficult clinical problem, there is need for adequate, effective therapy. In this study, we explored for the first time the efficacy and the potential synergetic effect of combined triamcinolone and verapamil for the treatment of hypertrophic and keloid scars. The objective was to assess the efficacy of combined intralesional triamcinolone and verapamil therapy for hypertrophic and keloid scars. Read More

View Article
June 2017
1 Read

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation.

Adv Wound Care (New Rochelle) 2018 Feb;7(2):47-56

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California.

Excessive scarring is major clinical and financial burden in the United States. Improved therapies are necessary to reduce scarring, especially in patients affected by hypertrophic and keloid scars. Advances in our understanding of mechanical forces in the wound environment enable us to target mechanical forces to minimize scar formation. Read More

View Article
February 2018
5 Reads

[Advances in the research of relationship between CD26 and hypertrophic scar and keloid].

Authors:
C L Song M Yao

Zhonghua Shao Shang Za Zhi 2018 Jan;34(1):54-56

Department of Plastic Surgery and Burns, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China.

In recent years, researchers have found that CD26 (dipeptidyl peptidase 4) is closely related to the formation and development of many fibrotic diseases. Hypertrophic scar, keloid, and other skin fibrosis diseases are major problems nowadays, which may affect the patient's appearance and cause joints deformity and dysfunction due to scar contracture. This article briefly reviews the relationship between CD26 and hypertrophic scar and keloid to provide new insights into the treatment of skin fibrotic diseases. Read More

View Article
January 2018

Inhibition of IRE1 results in decreased scar formation.

Wound Repair Regen 2017 11 6;25(6):964-971. Epub 2018 Feb 6.

Department of Surgery, Stanford University School of Medicine, Stanford, California.

Wound healing is characterized by the production of large amounts of protein necessary to replace lost cellular mass and extracellular matrix. The unfolded protein response (UPR) is an important adaptive cellular response to increased protein synthesis. One of the main components of the UPR is IRE1, an endoplasmic reticulum transmembrane protein with endonuclease activity that produces the activated form of the transcription factor XBP1. Read More

View Article
November 2017
6 Reads

Commentary on The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review.

Dermatol Surg 2018 02;44(2):158

Carruthers Dermatology Centre, Dermatology Vancouver, British Columbia, Canada.

View Article
February 2018
3 Reads

Comparison of the effectiveness of topical silicone gel and corticosteroid cream on the pfannenstiel scar prevention - a randomized controlled trial.

Ginekol Pol 2017 ;88(11):591-598

Acıbadem Kozyatagı Hospital, Department of Obstetrics and Gynecology, Inonu Caddesi, Okur Sokak, No:20 Kozyatagı, 34742 Istanbul, Turkey.

Objectives: To compare the effects of topical silicone gel and corticosteroid cream for preventing hypertrophic scar and keloid formation following Pfannenstiel incisions.

Material And Methods: Fifty patients operated for benign gynecological diseases through primary Pfannenstiel incision were included. The wounds were randomly allocated to the treatment and control arms. Read More

View Article
January 2017
5 Reads

High-Mobility Group Box 1 Mediates Fibroblast Activity via RAGE-MAPK and NF-κB Signaling in Keloid Scar Formation.

Int J Mol Sci 2017 Dec 28;19(1). Epub 2017 Dec 28.

Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul 03722, Korea.

Emerging studies have revealed the involvement of high-mobility group box 1 (HMGB1) in systemic fibrotic diseases, yet its role in the cutaneous scarring process has not yet been investigated. We hypothesized that HMGB1 may promote fibroblast activity to cause abnormal cutaneous scarring. In vitro wound healing assay with normal and keloid fibroblasts demonstrated that HMGB1 administration promoted the migration of both fibroblasts with increased speed and a greater traveling distance. Read More

View Article
December 2017
9 Reads

Techniques for Optimizing Surgical Scars, Part 2: Hypertrophic Scars and Keloids.

Skinmed 2017 1;15(6):451-456. Epub 2017 Dec 1.

Refresh Dermatology, Houston, TX;

Surgical management of benign or malignant cutaneous tumors may result in noticeable scars that are of great concern to patients, regardless of sex, age, or ethnicity. Techniques to optimize surgical scars are discussed in this three-part review. Part 2 focuses on scar revision for hypertrophic and keloids scars. Read More

View Article
December 2017
6 Reads

Identification of the potential targets for keloid and hypertrophic scar prevention.

J Dermatolog Treat 2018 Jan 10:1-6. Epub 2018 Jan 10.

b Department of Thyroid Surgery , China-Japan Union Hospital of Jilin University , Changchun , China.

Purpose: We aimed to explore the molecular mechanism of pathologic skin scar and novel target for scar prevention.

Materials And Methods: Microarray data derived from keloid and hypertrophic scar were downloaded from ArrayExpress database. The common differentially expressed genes (DEGs) in keloid and hypertrophic scar samples were investigated by function and pathway analysis. Read More

View Article
January 2018
4 Reads

Wound healing.

J Chin Med Assoc 2018 02 21;81(2):94-101. Epub 2017 Nov 21.

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Obstetric and Gynecology, National Yang-Ming University, Taipei, Taiwan, ROC; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.

Wound healing is an important physiological process to maintain the integrity of skin after trauma, either by accident or by intent procedure. The normal wound healing involves three successive but overlapping phases, including hemostasis/inflammatory phase, proliferative phase, and remodeling phase. Aberration of wound healing, such as excessive wound healing (hypertrophic scar and keloid) or chronic wound (ulcer) impairs the normal physical function. Read More

View Article
February 2018
7 Reads

The Superficial Dermis May Initiate Keloid Formation: Histological Analysis of the Keloid Dermis at Different Depths.

Front Physiol 2017 7;8:885. Epub 2017 Nov 7.

The Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce. The aim of this study was to investigate the histology of the keloid dermis at different depths. This study included 19 keloid tissue samples that were collected from 19 patients and 19 normal skin samples, which were harvested from subjects without keloids or hypertrophic scar. Read More

View Article
November 2017
2 Reads

Surgical management of extensive hypertrophic scarring of the halluces secondary to a decade of untreated onychocryptosis: An illustrative case report.

SAGE Open Med Case Rep 2017 6;5:2050313X17740514. Epub 2017 Nov 6.

Australasian College of Podiatric Surgeons, Melbourne, VIC, Australia.

Extensive hypertrophic scarring of the halluces secondary to chronic onychocryptosis is a rare condition, which causes significant physical and psychosocial effects. In this case, a 31-year-old male developed large lesions on both great toes after he delayed treatment of chronic hallucal onychocryptosis for over a decade. Current treatment options for hypertrophic and keloid lesions in the foot and ankle vary considerably and differentiation is critical for appropriate treatment planning. Read More

View Article
November 2017
1 Read

The role of TGFβ in wound healing pathologies.

Mech Ageing Dev 2018 Jun 11;172:51-58. Epub 2017 Nov 11.

Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Wound healing is one of the most complex processes in multicellular organisms, involving numerous intra- and intercellular signalling pathways in various cell types. It involves extensive communication between the cellular constituents of diverse skin compartments and its extracellular matrix. Miscommunication during healing may have two distinct damaging consequences: the development of a chronic wound or the formation of a hypertrophic scar/keloid. Read More

View Article
June 2018
2 Reads

[Therapy of scars with lasers].

Hautarzt 2018 Jan;69(1):17-26

Skin House, Mailand, Italien.

Scar formation is the consequence of trauma to the skin that affects the deep parts of the dermis. Different scar types like immature, mature, atrophic, hypertrophic, or keloid scars can develop depending on factors like age, anatomic localization, cause of trauma, the course of the healing process, and individual predispositions. Keloids and hypertrophic scars are often associated with itching, pain, tautness of the skin, and functional impairments, thus, leading to significantly reduced quality of life in some patients. Read More

View Article
January 2018
3 Reads

The tension biology of wound healing.

Exp Dermatol 2017 Nov 4. Epub 2017 Nov 4.

International Research Center of Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan.

Following skin wounding, the healing outcome can be: regeneration, repair with normal scar tissue, repair with hypertrophic scar tissue or the formation of keloids. The role of chemical factors in wound healing has been extensively explored, and while there is evidence suggesting the role of mechanical forces, its influence is much less well defined. Here, we provide a brief review on the recent progress of the role of mechanical force in skin wound healing by comparing laboratory mice, African spiny mice, fetal wound healing and adult scar keloid formation. Read More

View Article
November 2017
4 Reads

Observer-blind randomized controlled study of a cosmetic blend of safflower, olive and other plant oils in the improvement of scar and striae appearance.

Int J Cosmet Sci 2018 Feb 12;40(1):81-86. Epub 2017 Dec 12.

proDERM, Institute for Applied Dermatological Research GmbH, Kiebitzweg 2, Schenefeld/Hamburg, DE 22869, Germany.

Objective: The normal process of skin tissue repair following injury invariably results in visual scarring. It is known that topical treatment with hydrophobic cosmetics rich in silicone and mineral oil content can improve the appearance of scars and striae. Given lifestyle preferences of many cosmetic consumers towards so-called natural treatments, the objective of this controlled randomized study was to investigate the efficacy of a plant body oil rich in oleic and linoleic acids (Bio Skin Oil ) for improving the appearance of scars and striae. Read More

View Article
February 2018
2 Reads

Downregulation of microRNA-31 inhibits proliferation and induces apoptosis by targeting in human keloid.

Oncotarget 2017 Sep 16;8(43):74623-74634. Epub 2017 Aug 16.

Department of Dermatology, the First Affiliated Hospital of Kunming Medical University, Kunming, China.

microRNAs (miRNAs) play a pivotal role in the regulation of cell proliferation and apoptosis in keloid scarring. Integrative analysis of the previous miRNA microarray revealed miRNA-31 was among the most frequently altered miRNAs in keloid and hypertrophic scar. Using qRT-PCR, we further validated miRNA-31 was increased in keloid tissues and keloid-derived fibroblasts. Read More

View Article
September 2017
5 Reads

A novel model of humanised keloid scarring in mice.

Int Wound J 2018 Feb 27;15(1):90-94. Epub 2017 Oct 27.

Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, P.R. China.

Treatments for keloid scarring are a major challenge to scientists and physicians for their unknown aetiology. Although several models, including monolayer cell culture to tissue-engineered models, were developed, further research on keloid has more or less been hindered by the lack of appropriate animal models. Because these aberrant scars are specific to humans, we obtained human normal and keloid skin tissues and isolated dermal fibroblasts from them. Read More

View Article
February 2018
1 Read

How Signaling Molecules Regulate Tumor Microenvironment: Parallels to Wound Repair.

Molecules 2017 Oct 26;22(11). Epub 2017 Oct 26.

Institute of Anatomy, 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.

It is now suggested that the inhibition of biological programs that are associated with the tumor microenvironment may be critical to the diagnostics, prevention and treatment of cancer. On the other hand, a suitable wound microenvironment would accelerate tissue repair and prevent extensive scar formation. In the present review paper, we define key signaling molecules (growth factors, cytokines, chemokines, and galectins) involved in the formation of the tumor microenvironment that decrease overall survival and increase drug resistance in cancer suffering patients. Read More

View Article
October 2017
1 Read

Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids.

Medicine (Baltimore) 2017 Oct;96(43):e8353

aDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine bShanghai Key Laboratory of Tissue Engineering, Shanghai, China.

Intralesional steroid injections are the standard treatment for hypertrophic scars and keloids. The procedure is, however, quite painful and is unpopular with patients because of this. Topical application of anesthetic creams, such as Ametop gel (tetracaine) and EMLA cream (lidocaine and prilocaine), has limited efficacy because of poor drug penetration. Read More

View Article
October 2017
3 Reads

[Advances in the research of treatment of angiogenesis inhibitor on pathological scars].

Authors:
L Dong Y Fang

Zhonghua Shao Shang Za Zhi 2017 Oct;33(10):653-656

Department of Burns and Plastic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China.

Angiogenesis inhibitors are a class of agents that prevent the angiogenesis by inhibiting the activation, migration, and proliferation of endothelial cells. In recent years, studies have found that there was a close relationship between the occurrence of pathological scars and angiogenesis. The vascular density in pathological scars is significantly higher than that in normal skin and scars. Read More

View Article
October 2017
1 Read

Treatment of keloid scars using light-, laser- and energy-based devices: a contemporary review of the literature.

Lasers Med Sci 2017 Dec 18;32(9):2145-2154. Epub 2017 Oct 18.

Dermatological Surgery & Laser Unit, St John's Institute of Dermatology,, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.

Keloid scars are common and have a predilection for young, ethnic skin often with a family history. Keloids can be painful and pruritic and cause significant emotional distress when particularly visible or prominent. In this article, we review the evidence underlying the use of laser- and energy-based devices for treatment of keloid scars, either as monotherapy or in conjunction with other therapies such as corticosteroids, surgery and silicone gel in the treatment of keloid scars. Read More

View Article
December 2017
2 Reads

Effects of Topical Tamoxifen on Wound Healing of Burned Skin in Rats.

Arch Plast Surg 2017 Sep 15;44(5):378-383. Epub 2017 Sep 15.

Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: This study aimed to assess the effects of the topical application of tamoxifen on wound healing of burned skin in Wistar rats by evaluating 3 healing characteristics: fibrotic tissue thickness (FTT), scar surface area (SSA), and angiogenesis in the healed scar tissue.

Methods: Eighteen male Wistar rats were used in this study. A third-degree burn wound was made on the shaved animals' back, measuring 2×2×2 cm. Read More

View Article
September 2017
5 Reads

Microneedle physical contact as a therapeutic for abnormal scars.

Eur J Med Res 2017 Aug 14;22(1):28. Epub 2017 Aug 14.

School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457, Singapore.

Background: Abnormal (keloid and hypertrophic) scars are a significant affliction with no satisfactory single modality therapy to-date. Available options are often ineffective, painful, potentially hazardous, and require healthcare personnel involvement. Herein a self-administered microneedle device based on drug-free physical contact for inhibiting abnormal scars is reported. Read More

View Article
August 2017
33 Reads

Evaluation of nonablative fractional laser treatment in scar reduction.

Authors:
Hilal Gokalp

Lasers Med Sci 2017 Sep 12;32(7):1629-1635. Epub 2017 Aug 12.

Department of Dermatology, Koç University School of Medicine, Davutpasa Cad, No:4, Topkapı, 34010, Istanbul, Turkey.

Fractional lasers have been used for the improvement of scar tissue in the recent years but there has not been extensive research on their impact. The purpose of this study was to evaluate the efficacy of nonablative fractional laser (NAFL) on acne, burn, and surgery/traumatic scar. The scars were also categorized as atrophic, hypertrophic, and keloid, and treatment efficacy was investigated accordingly. Read More

View Article
September 2017
1 Read

The "Sandwich Therapy": A Microsurgical Integrated Approach for Presternal Keloid Treatment.

Ann Plast Surg 2017 Sep;79(3):280-285

From the Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Background: Keloid therapy remains a great challenge for plastic surgeons, especially when the defect cannot be closed primarily, necessitating tissue transplantation. Here, we introduce a new treatment modality, called the sandwich therapy, for presternal keloids; the sandwich therapy incorporates preradiotherapy, superficial circumflex iliac artery perforator (SCIP) flap transplantation, and postradiotherapy.

Methods: From December 2012 to October 2013, 12 patients received the "sandwich therapy. Read More

View Article
September 2017
4 Reads

MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment.

Mol Diagn Ther 2017 Dec;21(6):633-642

Department of Physiology, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong, Kunming, 650500, Yunnan, China.

Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix. However, the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-21 may play pivotal roles in the regulation of a variety of skin fibrosis, including keloid, scleroderma, and hypertrophic scar. Read More

View Article
December 2017
2 Reads

Isotretinoin and Timing of Procedural Interventions: A Systematic Review With Consensus Recommendations.

JAMA Dermatol 2017 Aug;153(8):802-809

Pennsylvania State University, Hershey.

Importance: The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s.

Objective: To evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions performed either concurrently with, or immediately following the cessation of systemic isotretinoin therapy.

Evidence Review: A panel of national experts in pediatric dermatology, procedural/cosmetic dermatology, plastic surgery, scars, wound healing, acne, and isotretinoin was convened. Read More

View Article
August 2017
45 Reads

Review of Silicone Gel Sheeting and Silicone Gel for the Prevention of Hypertrophic Scars and Keloids.

Wounds 2017 May;29(5):154-158

Department of Surgery, Kaohsiung, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Background: Keloids and hypertrophic scars are fibroproliferative disorders of dermal tissue after skin injury. Many clinical control studies have reported evidence that silicone gel is effective in preventing and alleviating hypertrophic scarring. Whether silicone gel sheeting prevents hypertrophic scars or keloids requires clear evidence of its clinical effectiveness. Read More

View Article
May 2017
1 Read

Reconstitution of Human Keloids in Mouse Skin.

Plast Reconstr Surg Glob Open 2017 Apr 25;5(4):e1304. Epub 2017 Apr 25.

Department of Plastic Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.

Background: Keloids are a dermal fibroproliferative scar of unknown etiology. There is no good animal model for the study of keloids, which hinders the development and assessment of treatments for keloids.

Methods: Human keratinocytes and dermal fibroblasts were isolated from 3 human skin tissues: normal skin, white scars, and keloids. Read More

View Article
April 2017
7 Reads

Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection.

Asia Pac Allergy 2017 Apr 6;7(2):115-118. Epub 2017 Apr 6.

Division of Allergy, Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. Read More

View Article
April 2017
13 Reads

Safety and Patient Satisfaction of AbobotulinumtoxinA for Aesthetic Use: A Systematic Review.

Aesthet Surg J 2017 05;37(suppl_1):S32-S44

Full Professor of Plastic and Reconstructive Surgery, Department of Surgery, Sapienza University of Rome, Rome, Italy.

A systematic review of the published literature (from January 2000 to January 2016) to ascertain the safety of, and patient satisfaction with, the aesthetic use of abobotulinumtoxinA was conducted. In addition to the licensed indications, other special populations were considered for discussion. The potential impact of neutralizing antibodies and systemic toxicity were also addressed. Read More

View Article
May 2017
1 Read

New Uses of AbobotulinumtoxinA in Aesthetics.

Aesthet Surg J 2017 05;37(suppl_1):S45-S58

Dermatologist in private practice in Miami, FL, USA.

BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

View Article
May 2017
3 Reads

Hypochlorous acid gel technology-Its impact on postprocedure treatment and scar prevention.

J Cosmet Dermatol 2017 Jun 30;16(2):162-167. Epub 2017 Mar 30.

Faculty of Medicine, McGill University,Montreal, Canada.

Background: A pre-and postprocedure regime aimed at prevention of infection, reduction of inflammation and risk of scarring, is to enable optimal outcomes.

Objectives: The role of a hypochlorous acid containing spray and translucent scar gel formulation that combines modified silicon oil with hypochlorous acid, was explored for pre- and postprocedure treatment and scar management.

Methods: For this purpose a literature review was conducted to explore the value of the technology used in pre-and postprocedural regimes. Read More

View Article
June 2017
5 Reads

The Use of Silgel STC-SE, a Topical Silicone Gel for the Treatment and Reduction of Hypertrophic and Keloid Scars.

Plast Reconstr Surg Glob Open 2016 Dec 23;4(12):e1183. Epub 2016 Dec 23.

Clinical Research Department, GC Aesthetics, Cumbernauld, Scotland.

Background: A single-center study assessing the efficacy of Nagor's Silgel STC-SE silicone gel to reduce the appearance of hypertrophic and keloid scars.

Methods: A 16-week controlled study of 36 patients with hypertrophic or keloid scars. The subjects were divided between 2 cohorts: one assessing recently healed scars (<6 mo) and other assessing older scars (6 mo to 2 y). Read More

View Article
December 2016
1 Read

Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis.

Authors:
Rei Ogawa

Int J Mol Sci 2017 Mar 10;18(3). Epub 2017 Mar 10.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo 113-8603, Japan.

Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. Read More

View Article
March 2017
5 Reads

Lasers and ancillary treatments for scar management Part 2: Keloid, hypertrophic, pigmented and acne scars.

Scars Burn Heal 2017 Jan-Dec;3:2059513116689805. Epub 2017 Mar 14.

Welsh Regional Burns, Plastic, Reconstructive Surgery and Laser Unit, Morriston Hospital, Swansea, Wales, UK.

The formation of a wide range of excessive scars following various skin injuries is a natural consequence of healing. Scars resulting from surgery or trauma affect approximately 100 million people per annum in the developed world and can have profound physical, aesthetic, psychological and social consequences. Thus, scar treatment is a priority for patient and physician alike. Read More

View Article