1,021 results match your criteria Keloid and Hypertrophic Scar


Efficacy and safety of verapamil vs triamcinolone acetonide for keloids and hypertrophic scars: a systematic review and meta-analysis.

Dermatol Ther 2020 May 13:e13564. Epub 2020 May 13.

Department of Plastic Surgery, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, People's Republic of China.

Background: The treatment of keloids and hypertrophic scars remains a challenge. Although triamcinolone acetonide (TAC) is one of the most common and effective treatments for keloids and hypertrophic scars, TAC is not effective in some patients, and some may even experience adverse outcomes. Verapamil might be considered a safe alternative to TAC. Read More

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http://dx.doi.org/10.1111/dth.13564DOI Listing

The JAK2/STAT3 pathway inhibitor, AG490, suppresses the abnormal behavior of keloid fibroblasts in vitro.

Int J Mol Med 2020 Apr 29. Epub 2020 Apr 29.

Department of Dermatology, Jiangsu Province People's Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu 210029, P.R. China.

AG490 is a selective inhibitor of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway. The present study examined its effects on the abnormal behavior of human keloid fibroblasts (HKFs) and evaluated its potential use in the treatment of keloids. Human normal fibroblasts (HNFs) and HKFs were treated with increasing concentrations of AG490. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4592DOI Listing

Laser management of hypertrophic burn scars: a comprehensive review.

Burns Trauma 2020 16;8:tkz002. Epub 2020 Jan 16.

Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland, USA, 21205.

Hypertrophic scars often develop following burn-related injuries. These scars can be cosmetically unappealing, but associated symptoms of pruritus, pain and restricted range of motion can impair a person's quality of life. Laser and light therapies offer a minimally invasive, low-risk approach to treatment, with a short postoperative recovery period. Read More

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http://dx.doi.org/10.1093/burnst/tkz002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175764PMC
January 2020

Efficacy and Safety of Intralesional Triamcinolone Versus Combination of Triamcinolone with 5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis.

Aesthetic Plast Surg 2020 Apr 27. Epub 2020 Apr 27.

The Department of Burn, The First Affiliated Hospital of Nanchang University, No.17 Yong Wai Street, Nanchang, 330006, Jiangxi, People's Republic of China.

Background: Although keloids and hypertrophic scars are common benign hyperproliferative growths of dermal fibroblasts, the clinical problems including physical and psychological problems are significant and impairing, with few proven treatments. Intralesional triamcinolone acetonide (TAC) and combination of TAC with 5-fluorouracil (5-FU) are widely used to treat keloids and hypertrophic scars, but their efficacy and safety remain controversial.

Methods: We systematically searched MEDLINE, EMBASE, Cochrane Library, and CNKI for relevant trials. Read More

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http://dx.doi.org/10.1007/s00266-020-01721-2DOI Listing

The role of macrophages in the formation of hypertrophic scars and keloids.

Burns Trauma 2020 11;8:tkaa006. Epub 2020 Mar 11.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China.

Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation. However, few reviews have highlighted the significance of macrophages during the formation of abnormal scars. The purpose of this review was to outline the polarization of macrophages from early to late stage of pathological scar formation, focusing on spatiotemporal diversity of M1 and M2 macrophages. Read More

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http://dx.doi.org/10.1093/burnst/tkaa006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175772PMC

Laser fluorescence spectroscopy in predicting the formation of a keloid scar: preliminary results and the role of lipopigments.

Biomed Opt Express 2020 Apr 2;11(4):1742-1751. Epub 2020 Mar 2.

Moscow Regional Research and Clinical Institute, 61/2 Shchepkina str., Moscow, 129110, Russia.

Keloid scars, in contrast to other scar types, significantly reduce the patient's quality of life. To develop a nondestructive optical diagnostic technique predicting the keloid scars formation , laser-induced fluorescence spectroscopy (LFS) was used to study the autofluorescence in skin of patients with various types of head and neck cicatricial deformities. The unexpected results were obtained for the endogenous fluorescence of lipofuscin. Read More

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http://dx.doi.org/10.1364/BOE.386029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173908PMC

Wnt Signaling Pathway Proteins in Scar, Hypertrophic Scar, and Keloid: Evidence for a Continuum?

Am J Dermatopathol 2020 Apr 17. Epub 2020 Apr 17.

Pathology Service, Dermatopathology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Hypertrophic scars and keloids are fibroproliferative lesions characterized by excessive collagen deposition. It is unclear whether these entities represent distinct disorders or share a common pathogenesis and the molecular underpinnings of these lesions are poorly understood. Accumulating evidence suggests that the Wnt signaling pathway is a key regulator of wound healing. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001661DOI Listing
April 2020
1.426 Impact Factor

DPP-4 Inhibitor Reduces the Risk of Developing Hypertrophic Scars and Keloids following Median Sternotomy in Diabetic Patients: A nationwide retrospective cohort study using the National Database of Health Insurance Claims of Japan.

Plast Reconstr Surg 2020 Apr 13. Epub 2020 Apr 13.

Assistant Professor, Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, 6-7-1 Nishishinjyuku Shinjyuku-ku Tokyo, 160-0023, Japan. Email: Lecturer, Kanagawa University of Human Services, Faculty of Health and Social Services, 1-10-1 Heiseichou Yokosukasi Kanagawa, 238-0013, Japan. Email: Instructor, Department of Plastic and Reconstructive Surgery, Tokyo Medical University, 6-7-1 Nishishinjyuku Shinjyuku-ku Tokyo, 160-0023, Japan. Email: Professor, Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, 6-7-1 Nishishinjyuku Shinjyuku-ku Tokyo, 160-0023, Japan. Email: Professor, Department of Plastic and Reconstructive Surgery, General Informatics Division, Tokyo Medical University, 6-7-1 Nishishinjyuku Shinjyuku-ku Tokyo, 160-0023, Japan. Email:

Background: Hypertrophic scars and keloids, which are abnormalities of fibrosis, often occur in surgical wounds; however, their exact cause and preventive measures are unknown. The administration of dipeptidyl peptidase-4 (DPP-4) inhibitors to humans is expected to suppress fibrosis in wounds and minimize hypertrophic scar and keloid formation.

Methods: This study aimed to verify suppressive effect of DPP-4 inhibitors on the formation of hypertrophic scars or keloids using real world data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB). Read More

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http://dx.doi.org/10.1097/PRS.0000000000006904DOI Listing

The efficacy of bleomycin for treating keloid and hypertrophic scar: A systematic review and meta-analysis.

J Cosmet Dermatol 2020 Apr 3. Epub 2020 Apr 3.

Department of Dermatology, Soonchunhyang University Hospital, Seoul, Korea.

Background: Pathologic scars can lead to itching, erythema, and psychological stress due to cosmetic problems. Bleomycin, one of anticancer agents, has been used for treating keloid or hypertrophic scar. Some studies have shown that bleomycin can induce markedly scar improvement. Read More

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http://dx.doi.org/10.1111/jocd.13390DOI Listing

Morphea With Keloidal Features: A Case Report and Review of the Literature.

Am J Dermatopathol 2020 Mar 6. Epub 2020 Mar 6.

Departments of Pathology, and.

Keloidal morphea is a rare variant of scleroderma, which often can be clinically confused with keloid or scar formation. We report a 34-year-old woman with a medical history of asthma and Raynaud's phenomenon, presented for the evaluation and management of multiple erythematous hyperpigmented annular plaques reportedly developed after taking trimethoprim/sulfamethoxazole. An initial skin biopsy showed findings supportive of a drug eruption. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001629DOI Listing

Keloid and Hypertrophic Scar Formation, Prevention, and Management: Standard Review of Abnormal Scarring in Orthopaedic Surgery.

J Am Acad Orthop Surg 2020 May;28(10):e408-e414

From the Prisma Health-USC Departments of Orthopaedic Surgery and Plastic Surgery, Columbia, SC.

Keloid and hypertrophic scar formation after orthopaedic surgical closure is a complex issue. The nature and location of procedures maximize wound tension, leave foreign bodies, and diminish dermal supply, all potentiating keloid formation. There is little discussion regarding the pathophysiology and management of this recurrent problem in orthopaedic literature. Read More

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http://dx.doi.org/10.5435/JAAOS-D-19-00690DOI Listing

Cutaneous laser surgery for secondary burn reconstruction: Cost benefit analysis.

Burns 2020 May 16;46(3):561-566. Epub 2020 Jan 16.

The Welsh Laser Centre, the R&D Dept, Swansea Bay University Health Board Swansea, Wales, UK; Welsh Centre for Burns and Plastic Surgery Wales, UK.

Thermal disease presents a major burden to individual patient morbidity, healthcare cost as well as to over all economy. Burns also also represent a significant per-patient utlilisation of finite healthcare resources. Secondary complications in these patients, such as multiple drug resistant organisms, may have a devastating effect. Read More

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http://dx.doi.org/10.1016/j.burns.2019.08.021DOI Listing

Heterogeneity of human fibroblasts isolated from hypertrophic scar.

Rom J Morphol Embryol 2019 ;60(3):793-802

Laboratory of Mesenchymal Stromal Progenitor Cells Therapy, Department of Regenerative Medicine, "Nicolae Simionescu" Institute of Cellular Biology and Pathology of the Romanian Academy, Bucharest, Romania;

Pathological wound healing states, such as hypertrophic scarring and keloids, represent a huge clinical and financial burden on healthcare system. The complex biological mechanisms occurring in hypertrophic scarring are still barely understood. To date, there is no satisfactory description of hypertrophic fibroblasts. Read More

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Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures.

J Cosmet Dermatol 2020 Feb 6;19(2):270-277. Epub 2020 Jan 6.

Skin and Allergy Center, Spring Hill, TN, USA.

Background: Hypochlorous acid (HOCl), a naturally occurring molecule produced by the immune system, is highly active against bacterial, viral, and fungal microorganisms. Moreover, HOCl is active against biofilm and increases oxygenation of the wound site to improve healing. Natural HOCl is unstable; through technology, it can be stabilized into an effective topical antiseptic agent. Read More

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http://dx.doi.org/10.1111/jocd.13280DOI Listing
February 2020

Diagnosis and Treatment of Keloids and Hypertrophic Scars-Japan Scar Workshop Consensus Document 2018.

Burns Trauma 2019 27;7:39. Epub 2019 Dec 27.

16Department of Radiation Oncology, Nippon Medical School Hospital, Tokyo, 113-8603 Japan.

There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases. This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases. By contrast, Caucasians are less likely to develop keloids and hypertrophic scars, and if they do, the scars tend not to be severe. Read More

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http://dx.doi.org/10.1186/s41038-019-0175-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933735PMC
December 2019

Comments on"Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomisedcontrol trial".

Burns 2020 03 19;46(2):490-491. Epub 2019 Dec 19.

Department of Burns and Plastic Surgery, The Affiliated Hospital of Jiangnan University, Xingyuan Wuxi, China, 214041; Department of Burns and Plastic Surgery, The Third Affiliated Hospital of Nantong University, Wuxi, Jiangsu, China, 214041.

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http://dx.doi.org/10.1016/j.burns.2018.10.029DOI Listing

The Efficacy of Drug Injection in the Treatment of Pathological Scar: A Network Meta-analysis.

Aesthetic Plast Surg 2019 Dec 18. Epub 2019 Dec 18.

Department of Plastic Surgery, Qilu Hospital of Shandong University, Jinan, People's Republic of China.

Background: Pathological scars mainly include hyperplastic scars and keloids, and there is no uniform treatment standard for the treatment of pathological scar in clinic now. Drug injection in the treatment of pathological scar is widely used because of its advantages of less trauma and simple operation. Therefore, we used a network meta-analysis to compare the curative effect of four kinds of drugs which are commonly used in the treatment of pathological scar such as botulinum toxin type A, corticosteroids (including diprospan and triamcinolone acetonide (TAC)), verapamil and 5-fluorouracil (5-FU), systematically. Read More

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http://dx.doi.org/10.1007/s00266-019-01570-8DOI Listing
December 2019

THE USAGE OF RADIOFREQUENCY ABLATION FOR TREATMENT OF KELOIDS AND HYPERTROPHIC SCARS.

Probl Radiac Med Radiobiol 2019 Dec;24:561-573

Bogomolets National Medical University, 13 T. Shevchenko Blvd., Kyiv, 01601, Ukraine.

Objective: To evaluate the effectiveness of radiofrequency ablation (RFA) for scars tissue volume reduction, and influence on the clinical manifestations of keloid and hypertrophic scars.

Materials And Methods: Seventeen patients (9 males, 8 females), 19-62 years old, with some scars were enrolled into the prospective randomized controlled study: 10 with keloids, 7 with hypertrophic scars. Previous failed attempts to correct the scars were undertaken in 8 patients with keloids and in 3 patients with hypertrophic scars. Read More

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http://dx.doi.org/10.33145/2304-8336-2019-24-561-573DOI Listing
December 2019

Surgical excision and postoperative radiotherapy for keloids.

Scars Burn Heal 2019 Jan-Dec;5:2059513119891113. Epub 2019 Dec 10.

Department of Radiation Oncology, Nippon Medical School Hospital, Tokyo, Japan.

Keloids can be treated in a number of ways, including by surgery. Multiple studies now show that while surgical monotherapy associates with extremely high rates of recurrence (50%-80%), postoperative radiotherapy can significantly reduce these recurrence rates. Ongoing improvements in radiation technology have further increased the safety and efficacy of this combination protocol. Read More

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http://dx.doi.org/10.1177/2059513119891113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904783PMC
December 2019

Percutaneous collagen induction (microneedling) for the management of non-atrophic scars: literature review.

Scars Burn Heal 2019 Jan-Dec;5:2059513119880301. Epub 2019 Nov 26.

Queen Mary University of London, London, UK.

Introduction: Percutaneous collagen induction (PCI) or needling techniques are increasingly popular in the reconstructive and aesthetic arena. The underlying mechanisms of action rest on producing a pattern of non-ablative and non-confluent puncture wound pattern to the dermis with a resulting regenerative effect to the skin.

Methods: A detailed English literature review was conducted using PubMed Medline, Embase and Web of Science; the manuscripts were appraised and classified according to level of evidence as well risk of bias. Read More

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http://dx.doi.org/10.1177/2059513119880301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880027PMC
November 2019

Vascular Endothelial Growth Factor and Cutaneous Scarring.

Authors:
Traci A Wilgus

Adv Wound Care (New Rochelle) 2019 Dec 6;8(12):671-678. Epub 2019 Nov 6.

Department of Pathology, College of Medicine, The Ohio State University, Columbus, Ohio.

The proangiogenic mediator vascular endothelial growth factor (VEGF) plays an important role in cutaneous wound repair. Most of the work on VEGF and wound healing has focused on its role in mediating angiogenesis and how this affects wound closure rates. Less is known about how VEGF affects other phases of wound healing, including scar formation. Read More

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http://dx.doi.org/10.1089/wound.2018.0796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862968PMC
December 2019
4 Reads

[Use of Anterolateral Thigh Free Flap in the Treatment of a Sternal Keloid].

Acta Med Port 2019 Dec 2;32(12):784-787. Epub 2019 Dec 2.

Serviço de Cirurgia Plástica, Reconstrutiva, Craniomaxilofacial e Unidade de Microcirurgia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Porto. Portugal.

Hypertrophic and keloid scars represent hyperproliferative disorders that can have a significant impact on patients' lives. The authors present the case of a 53 years-old male with a sternal keloid after excision of a sebaceous cyst and multiple sessions of steroid infiltration, with worsening of the lesion. The patient underwent complete excision of the scar and reconstruction with an anterolateral thigh flap - ALT. Read More

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http://dx.doi.org/10.20344/amp.10955DOI Listing
December 2019

Literature review and case report of post-circumcision keloid management.

Arab J Urol 2019 7;17(4):314-317. Epub 2019 Aug 7.

Royal Hospital for Sick Children, Edinburgh, Scotland.

Keloid following circumcision has been described in the literature despite the rarity of its occurrence in penile skin. In this paper, we review the literature and report the successful management of post-circumcision keloid scarring in a 2-year-old boy. After circumcision a 2-year-old boy of African origin developed keloid scarring at the circumcision site. Read More

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http://dx.doi.org/10.1080/2090598X.2019.1651016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830255PMC

Scarring and wound healing.

Br J Hosp Med (Lond) 2019 Nov;80(11):C166-C171

Consultant Dermatologist and Honorary Associate Professor, Department of Dermatology, Leicester Royal Infirmary, Leicester.

Following injury, the skin undergoes a wound healing process culminating in the formation of a mature scar. Millions of patients worldwide are left with scars every year as a result of trauma or surgery. Scars can be painful, disfiguring and disabling, yet patients report that clinicians are often dismissive of their concerns, unable to identify pathological scars and unaware of treatment options. Read More

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http://dx.doi.org/10.12968/hmed.2019.80.11.C166DOI Listing
November 2019

Comparative Efficacy and Safety of Common Therapies in Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis.

Aesthetic Plast Surg 2020 02 21;44(1):207-218. Epub 2019 Oct 21.

Department of Plastic Surgery, First Affiliated Hospital of Anhui Medical University, 210 JiXi Road, Hefei, Anhui, China.

Objectives: At present, there are many therapies for treating keloids and hypertrophic scars, but there is still a lack of treatments that are relatively balanced in efficacy and safety. The study aims to evaluate comprehensively efficacy and safety of common therapies in keloids and hypertrophic scars.

Methods: The literature search was conducted up to May 2019. Read More

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http://dx.doi.org/10.1007/s00266-019-01518-yDOI Listing
February 2020
1 Read

Laser Therapy of Traumatic and Surgical Scars and an Algorithm for Their Treatment.

Lasers Surg Med 2020 Feb 17;52(2):125-136. Epub 2019 Oct 17.

Department of Dermatology, University of Texas MD Anderson Cancer Center, University of Texas, McGovern Medical School, 6655 Travis St. #700, Houston, Texas, 77030.

Background And Objectives: This paper describes the laser techniques available for the treatment of surgical and trauma scars and develops recommendations for an algorithmic-based treatment approach based on extensive clinical experience and published data.

Study Design/materials And Methods: We reviewed the literature regarding laser treatment of surgical and traumatic scars and incorporated the clinical experience of the authors to develop an algorithm for the treatment of surgical and trauma scars.

Results: In order to develop treatment recommendations, scars were differentiated based on their clinical characteristics. Read More

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http://dx.doi.org/10.1002/lsm.23171DOI Listing
February 2020
2 Reads

Management of Surgical Scars.

Facial Plast Surg Clin North Am 2019 Nov;27(4):513-517

Department of Otolaryngology-Head and Neck Surgery, Division of Facial Plastic and Reconstructive Surgery, University of Illinois at Chicago-College of Medicine, 1855 West Taylor Street, Suite 2.42 (MC 648), Chicago, IL 60612, USA.

An ideal scar is flat, thin, and color matched to the surrounding skin. Incision planning, skin closure, and postoperative care are vital to create an inconspicuous scar. Depressed, hypertrophic, and keloid scars each pose unique challenges to the facial plastic surgeon. Read More

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http://dx.doi.org/10.1016/j.fsc.2019.07.013DOI Listing
November 2019
1 Read

Early Postoperative Application of Botulinum Toxin Type A Prevents Hypertrophic Scarring after Epicanthoplasty: A Split-Face, Double-Blind, Randomized Trial.

Plast Reconstr Surg 2019 10;144(4):835-844

Shanghai, People's Republic of China; and Basel, Switzerland From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; and the Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, University Hospital Basel.

Background: Postoperative hypertrophic scarring of the medial canthal area is a common phenomenon and deterrent for patients considering epicanthoplasty. Botulinum toxin type A has been reported for hypertrophic scar and keloid treatment. However, there is a lack of high-level evidence regarding the effects of botulinum toxin type A in the medial canthal area. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006069DOI Listing
October 2019
2 Reads

Intralesional excision as a surgical strategy to manage keloid scars: what's the evidence?

Authors:
Ioannis Goutos

Scars Burn Heal 2019 Jan-Dec;5:2059513119867297. Epub 2019 Aug 27.

Centre for Cutaneous Research, Blizard Institute, London, UK.

Introduction: Keloid scars are a particularly challenging clinical entity and a variety of management approaches have been described in the literature including intralesional surgery. The current literature lacks a summative review to ascertain the evidence base behind this surgical approach.

Methods: A comprehensive English literature database search was performed using PubMed Medline, EMBASE and Web of Science from their individual dates of inception to March 2018. Read More

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http://dx.doi.org/10.1177/2059513119867297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755860PMC
August 2019
3 Reads

Analyses of size and computed tomography densitometry parameters for prediction of keloid recurrence after postoperative electron beam radiation therapy.

Skin Res Technol 2020 Jan 23;26(1):125-131. Epub 2019 Sep 23.

Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.

Background: The lesion size is a risk factor for keloid recurrence after postoperative radiotherapy. However, it remains unclear whether the major axis diameter is the most appropriate parameter to evaluate lesion size, because keloids are often irregular in shape. Additionally, no previous study has investigated computed tomography (CT) densitometry parameters of keloids as potential predictors for recurrence after postoperative radiotherapy. Read More

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http://dx.doi.org/10.1111/srt.12775DOI Listing
January 2020
2 Reads

Subcision and Microneedling as an Inexpensive and Safe Combination to Treat Atrophic Acne Scars in Dark Skin: A Prospective Study of 45 Patients at a Tertiary Care Center.

J Clin Aesthet Dermatol 2019 Aug 1;12(8):18-22. Epub 2019 Aug 1.

Bhargava, Kumar, and Varma are with the Department of Dermatology at R.D. Gardi Medical College in Ujjain, India.

Acne scars are the most common sequele of the inflammatory process of acne and affects almost 95 percent of the patients with acne vulgaris. Hypertrophic scars and keloid scars result from excessive tissue formation; atrophic scars are characterized by loss or damage of tissue, which are further categorized into ice pick, rolling, and boxcar scars. A total of 45 patients underwent four sessions, four weeks apart, of subcision and microneedling and were assessed for scar grading three months after the final treatment session. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715122PMC
August 2019
6 Reads

Battling Neuropathic Scar Pain With Botulinum Toxin

J Drugs Dermatol 2019 Sep;18(9):937-938

Botulinum toxin type A (BTA) is a neurotoxic protein that prevents the release of neurotransmitters from presynaptic nerves and has shown promise in treating neuropathic pain. Recently, BTA has been used to treat painful keloids and scars. We present a patient with refractory neuropathic pain in a normotrophic spread-scar treated with the injection of BTA. Read More

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September 2019
3 Reads

[Secondary surgical and medical treatment of scars].

Ann Chir Plast Esthet 2019 Nov 30;64(5-6):392-403. Epub 2019 Aug 30.

Carré esthétique Lafayette, 5, place Aristide-Briand, 44000 Nantes, France.

The authors, through their experience, take stock of current secondary management of scars whether they are pathological (hypertrophic, cheloid) or dystrophic (enlarged, hypo- or hyper-pigmented, adherent) by presenting surgical or medical solutions. Read More

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http://dx.doi.org/10.1016/j.anplas.2019.07.013DOI Listing
November 2019

Combination therapy using non-ablative fractional laser and intralesional triamcinolone injection for hypertrophic scars and keloids treatment.

Int Wound J 2019 Dec 2;16(6):1450-1456. Epub 2019 Sep 2.

Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu-si, Gyeonggi-do, Republic of Korea.

Combinations of various treatment modalities were shown to be more effective than monotherapy when treating hypertrophic scars and keloids. This study was conducted to assess the effectiveness of combination therapy with non-ablative fractional laser and intralesional steroid injection. From May 2015 to June 2017, a total of 38 patients with hypertrophic scars or keloids were evaluated. Read More

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http://dx.doi.org/10.1111/iwj.13213DOI Listing
December 2019
4 Reads

The effectiveness of a 595 nm pulsed-dye-laser in the treatment of surgical scars following a knee arthroplasty.

J Cosmet Laser Ther 2019 29;21(6):352-356. Epub 2019 Aug 29.

Dermatology unit, Department of Internal Medicine, Thammasat University , Bangkok , Thailand.

: A knee arthroplasty results in a long vertical scar on the knee and has a high risk for the development of hypertrophic or keloid scarring. The purpose of this study is to determine the efficacy and safety of the use of a 595 nm pulsed-dye-laser (PDL) for this type of scar. : This randomized, controlled study was conducted in 40 patients (41 scars) with postoperative knee arthroplasties. Read More

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http://dx.doi.org/10.1080/14764172.2019.1661488DOI Listing
March 2020
2 Reads

Keloid research: current status and future directions.

Scars Burn Heal 2019 Jan-Dec;5:2059513119868659. Epub 2019 Aug 19.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.

Introduction: Keloids and hypertrophic scars are fibroproliferative disorders of the skin that result from abnormal healing of injured or irritated skin. Multiple studies suggest that genetic, systemic and local factors may contribute to the development and/or growth of keloids and hypertrophic scars. A key local factor may be mechanical stimuli. Read More

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http://dx.doi.org/10.1177/2059513119868659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700880PMC
August 2019
6 Reads

[Giant right post-traumatic retroauricular keloid].

Pan Afr Med J 2019 28;33:62. Epub 2019 May 28.

Service de Radiologie, Hôpital Régional de Gao, Gao, Mali.

Keloid is a benign fibroblastic tumor which is most often secondary to a scar, but it can occur spontaneously in a subject with black skin. We report the case of a 19-year old patient, electrician, presenting with giant right retroauricular mass evolving over two years. For some time, the patient has experienced a feeling of heaviness on the pavilion of the right ear. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.62.16912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689837PMC
September 2019
2 Reads

Application of the Lalonde (horizontal-only scar) breast reduction technique for correction of gynaecomastia in dark skinned patients.

Gland Surg 2019 Jun;8(3):287-293

Department of Plastic & Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Surgical correction of gynaecomastia correction sometimes necessitates skin reduction in addition to resection of glandular tissue and liposuction of the fat deposits. Many skin reduction techniques have been described but all suffer from very noticeable and often poor scars that can manifest as hypertrophic or keloid scars in patients with dark skin. Three large gynaecomastia patients undergoing a modification of the Lalonde "no vertical scar" breast reduction technique designed to reduce the extent of scarring were reviewed. Read More

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http://dx.doi.org/10.21037/gs.2018.10.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606474PMC
June 2019
6 Reads

A dose-ranging, parallel group, split-face, single-blind phase II study of light emitting diode-red light (LED-RL) for skin scarring prevention: study protocol for a randomized controlled trial.

Trials 2019 Jul 15;20(1):432. Epub 2019 Jul 15.

Department of Dermatology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.

Background: Skin fibrosis is a significant global health problem that affects over 100 million people annually and has a profoundly negative impact on quality of life. Characterized by excessive fibroblast proliferation and collagen deposition, skin fibrosis underlies a wide spectrum of dermatologic conditions ranging from pathologic scars secondary to injury (e.g. Read More

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http://dx.doi.org/10.1186/s13063-019-3546-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631489PMC
July 2019
5 Reads

Update on the Treatment of Scars

J Drugs Dermatol 2019 Jun;18(6):550

Background: Treatment of scars continues to be a persisting challenge. Scar classification is paramount in determining an appropriate treatment strategy. They can be classified into hypertrophic, keloid, or atrophic scars. Read More

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June 2019
20 Reads

Discussion: The Interplay of Mechanical Stress, Strain, and Stiffness at the Keloid Periphery Correlates with Increased Caveolin-1/ROCK Signaling and Scar Progression.

Plast Reconstr Surg 2019 07;144(1):68e-69e

Boston, Mass. From the Division of Plastic Surgery, Brigham and Women's Hospital.

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http://dx.doi.org/10.1097/PRS.0000000000005718DOI Listing
July 2019
2 Reads

High-resolution ultrasound for keloids and hypertrophic scar assessment.

Lasers Med Sci 2020 Mar 25;35(2):379-385. Epub 2019 Jun 25.

Faculty of Medicine, Benha University, Banha, Egypt.

Most of the widely used scales to evaluate scars are subjective relying on clinical observations. There is a growing need to find out a noninvasive objective tool for this purpose. The study is aimed at evaluating the value of the high-resolution ultrasound in the assessment of the scars when compared with a clinical evaluation scoring system, the Vancouver Scar Scale (VSS). Read More

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http://dx.doi.org/10.1007/s10103-019-02830-4DOI Listing
March 2020
7 Reads

Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method.

Acta Dermatovenerol Alp Pannonica Adriat 2019 06;28(2):57-59

Department of Dermatology, Gülhane Medical Faculty, University of Health Sciences, Ankara, Turkey.

Introduction: The rabbit ear hypertrophic scar model is a preferred animal model of excessive scarring for investigating the scarring process and novel treatment modalities. In this model, surgical removal of perichondrium can be challenging, and it is often insufficient or damages the underlying cartilage. It is hypothesized that cryosurgery would offer a more efficient alternative to conventional surgery. Read More

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June 2019
21 Reads

Toward understanding scarless skin wound healing and pathological scarring.

F1000Res 2019 5;8. Epub 2019 Jun 5.

Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

The efficient healing of skin wounds is crucial for securing the vital barrier function of the skin, but pathological wound healing and scar formation are major medical problems causing both physiological and psychological challenges for patients. A number of tightly coordinated regenerative responses, including haemostasis, the migration of various cell types into the wound, inflammation, angiogenesis, and the formation of the extracellular matrix, are involved in the healing process. In this article, we summarise the central mechanisms and processes in excessive scarring and acute wound healing, which can lead to the formation of keloids or hypertrophic scars, the two types of fibrotic scars caused by burns or other traumas resulting in significant functional or aesthetic disadvantages. Read More

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http://dx.doi.org/10.12688/f1000research.18293.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556993PMC
June 2019
8 Reads

Hypertrophic and keloid scars fail to progress from the CD34 /α-smooth muscle actin (α-SMA) immature scar phenotype and show gradient differences in α-SMA and p16 expression.

Br J Dermatol 2020 Apr 4;182(4):974-986. Epub 2019 Sep 4.

Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Background: Our understanding of the pathogenesis underlying keloid scar formation is still very limited, and the morphological distinction between hypertrophic and keloid scars remains difficult.

Objectives: To test whether hypertrophic and keloid scars may reflect an inability to progress from immaturity to the desired mature normotrophic scar phenotype.

Methods: Using whole-biopsy imaging and an objectively quantifiable way to analyse immunoreactivity, we have compared the immunohistopathological profiles of young immature scars with mature normotrophic scars, hypertrophic scars, and keloids with their surrounding-normal-skin. Read More

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http://dx.doi.org/10.1111/bjd.18219DOI Listing
April 2020
13 Reads

[Keloid treatment : Where do we stand ?]

Rev Med Suisse 2019 Jun;15(655):1213-1216

Service de chirurgie plastique, reconstructive et esthétique, HUG, 1211 Genève 14.

Keloids are debilitating skin lesions that develop often as a result of minor skin lesions. Unlike hypertrophic scars, their main clinical feature is the tendency to extend beyond the initial limits of the wound. They can be responsible for pain and itching and may appear several months after the trauma. Read More

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June 2019
4 Reads

Nonsurgical Treatment of Keloids and Hypertrophic Scars.

Facial Plast Surg 2019 Jun 12;35(3):260-266. Epub 2019 Jun 12.

Surgery (Division of Otolaryngology - Head and Neck Surgery), University of California, San Diego, San Diego, California.

Despite the ubiquitous nature of scar tissue, there is not a single, reliable strategy to prevent or treat excessive scarring. The difficulty in arriving at a universally accepted form of management is multifaceted: there is an incomplete understanding of the complex pathophysiology of scar formation; a lack of common metrics hampers the accurate description of scar quality and characteristics; model systems do not exist for proper investigation in the controlled environment of a laboratory; and there is only limited data from prospective, randomized controlled clinical trials. Accordingly, the management of cutaneous scars is typically based upon the experience from practitioners rather than from evidence-based data. Read More

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http://dx.doi.org/10.1055/s-0039-1688847DOI Listing
June 2019
7 Reads

Epithelial-mesenchymal transition in the formation of hypertrophic scars and keloids.

J Cell Physiol 2019 12 20;234(12):21662-21669. Epub 2019 May 20.

Department of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, China.

Abnormal wound healing is likely to induce the formation of hypertrophic scars and keloids, which leads to dysfunction, deformity, and mental problem in the patients. Despite the advances in prevention and management of hypertrophic scar and keloids, the mechanism underlying scar and keloid formation has not been fully elucidated. Recent insights into the role of the epithelial-mesenchymal transition (EMT) in development, wound healing, stem cell regulation, fibrosis, and tumorigenesis have increased our understanding of the pathophysiology of hypertrophic scarring and keloids and suggested new therapeutic targets. Read More

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http://dx.doi.org/10.1002/jcp.28830DOI Listing
December 2019
2 Reads

Periostin is induced by IL-4/IL-13 in dermal fibroblasts and promotes RhoA/ROCK pathway-mediated TGF-β1 secretion in abnormal scar formation.

J Plast Surg Hand Surg 2019 Oct 8;53(5):288-294. Epub 2019 May 8.

Department of Plastic Surgery, Osaka University Graduate School of Medicine , Suita , Osaka , Japan.

Excess scar formation can occur after skin injurふy and lead to abnormal scar formation, such as keloids and hypertrophic scars, which are characterised by substantial deposition of extracellular matrix in the dermis. Periostin, an extracellular matrix protein that plays a crucial role in skin development and maintaining homeostasis, is also involved in skin disorders such as systemic/limited scleroderma, wound closure, and abnormal scar formation. However, the mechanism of periostin involvement in abnormal scar formation is not yet fully understood. Read More

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https://www.tandfonline.com/doi/full/10.1080/2000656X.2019.1
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http://dx.doi.org/10.1080/2000656X.2019.1612752DOI Listing
October 2019
21 Reads

Perception of Community and Hospital Personnel on Burn Treatment and Outcome in Nepal.

JNMA J Nepal Med Assoc 2018 Nov-Dec;56(214):924-930

Plastic and Reconstructive Surgery, Interplast Germany.

Introduction: Globally, eleven million people sustain burn injuries every year enough to require medical attention. WHO has estimated Disability associated limited years of 84,000 per year just due to deformities and 2100 people die every year due to burn injuries in Nepal. The overall objective of the study is to explore the effectiveness of burn injuries treatment and management approach of hospitals. Read More

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September 2019
8 Reads