1,111 results match your criteria Keloid and Hypertrophic Scar

[Influence of connective tissue differentiation on scar tissue formation in children].

Khirurgiia (Mosk) 2021 (5):72-77

Stavropol State Medical University, Stavropol, Russia.

Objective: To study the immunohistochemical features of various scar tissues in children without connective tissue pathology and with undifferentiated connective tissue dysplasia syndrome.

Material And Methods: Tissue biopsy was performed in 217 children who underwent surgical treatment for various lesions, such as injuries, burns, as well as other procedures. There were 127 boys (58. Read More

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A scoping review of the methodology used in studies of genetic influences on the development of keloid or hypertrophic scarring in adults and children after acute wounding.

Adv Wound Care (New Rochelle) 2021 May 11. Epub 2021 May 11.

Children's Burn Research Centre, University Hospital Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom of Great Britain and Northern Ireland.

Significance: Keloid and hypertrophic scarring are common following acute wounds. However, the variability in scarring outcomes between individuals and in particular, the association between genetic factors and scarring, is not well understood. This scoping review aims to summarise the methodology used in studies of genetic influences on the development of keloid or hypertrophic scarring in adults and children after acute wounding. Read More

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Notch-ing up knowledge on molecular mechanisms of skin fibrosis: focus on the multifaceted Notch signalling pathway.

J Biomed Sci 2021 May 9;28(1):36. Epub 2021 May 9.

Laboratory of Molecular and Cell Biology, IDI-IRCCS, via Monti di Creta 104, 00167, Rome, Italy.

Fibrosis can be defined as an excessive and deregulated deposition of extracellular matrix proteins, causing loss of physiological architecture and dysfunction of different tissues and organs. In the skin, fibrosis represents the hallmark of several acquired (e.g. Read More

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Therapeutic Strategies by Regulating Interleukin Family to Suppress Inflammation in Hypertrophic Scar and Keloid.

Front Pharmacol 2021 20;12:667763. Epub 2021 Apr 20.

Department of Plastic and Cosmetic Surgery, The Second Hospital of Dalian Medical University, Dalian, China.

Hypertrophic scar (HS) and keloid are fibroproliferative disorders (FPDs) of the skin due to aberrant wound healing, which cause disfigured appearance, discomfort, dysfunction, psychological stress, and patient frustration. The unclear pathogenesis behind HS and keloid is partially responsible for the clinical treatment stagnancy. However, there are now increasing evidences suggesting that inflammation is the initiator of HS and keloid formation. Read More

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A Deep Learning Based Framework for Diagnosing Multiple Skin Diseases in a Clinical Environment.

Front Med (Lausanne) 2021 16;8:626369. Epub 2021 Apr 16.

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Numerous studies have attempted to apply artificial intelligence (AI) in the dermatological field, mainly on the classification and segmentation of various dermatoses. However, researches under real clinical settings are scarce. This study was aimed to construct a novel framework based on deep learning trained by a dataset that represented the real clinical environment in a tertiary class hospital in China, for better adaptation of the AI application in clinical practice among Asian patients. Read More

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Peri-areolar double-pedicle technique in the treatment of iatrogenic gynecomastia.

Saudi Med J 2021 May;42(5):574-577

From the Unity of Plastic Surgery (Cannistrà), Bichat C.B. Hospital, and from the Pediatric Surgery Department (Al-Shaqsi), Armand Trousseau Hospital, Paris, France.

Objectives: To describe the surgical approach to the treatment of iatrogenic gynecomastia via peri-areolar incision.

Methods: In this study, we describe our experience in the surgical management of iatrogenic hormonal gynecomastia with our technique described for idiopathic gynecomastia. We treated 70 patients with gynecomastia at a plastic surgery unit between 2000 and 2016. Read More

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Suture Materials and Techniques for Optimal Cutaneous Wound Cosmesis: A Systematic Review.

J Am Acad Dermatol 2021 Apr 20. Epub 2021 Apr 20.

University of California, San Diego, Department of Dermatology, San Diego, CA.

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[Deliberation on the similarities and differences of the diagnosis and treatment of scars and keloids in China and Japan].

K Y Lyu Z F Xia

Zhonghua Shao Shang Za Zhi 2021 Apr;37(4):306-311

Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.

The incidence and clinical manifestations of scars and keloids are different in different races, and Asians are more likely to suffer from this disease than Caucasians. China and Japan are the representative countries for medical development in Asia. There is no comprehensive study on the similarities and differences between the academic circles in the two countries in the diagnosis and treatment of scars and keloids. Read More

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[Looking at the essence through the phenomenon: the tumor characteristics of keloid].

C Y Jia L X Chen

Zhonghua Shao Shang Za Zhi 2021 Mar 24;37:1-5. Epub 2021 Mar 24.

Department of Burns and Plastic & Wound Repair Surgery, Xiang'an Hospital of Xiamen University, Xiamen 361102, China.

In clinical work, it is observed that keloid has significantly different characteristics with other types of scar such as hypertrophic scar. The growth of keloid usually exceeds the margin of original wound, continuously invades the surrounding skin, and has certain recurrence rate after various treatment measures such as surgery and glucocorticoid injection, etc. The above phenomenon suggests that keloid has certain tumor characteristics, and we cannot just look at keloid from the perspective of scar. Read More

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Daily Quality-of-life Impact of Scars: An Interview-based Foundational Study of Patient-reported Themes.

Plast Reconstr Surg Glob Open 2021 Apr 15;9(4):e3522. Epub 2021 Apr 15.

Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Ill.

Background: Scars negatively impact mental health. Prior patient interview studies on cutaneous scars have elicited opinions pertaining to psychosocial effects, appearance, and symptoms. There remains a need for patient-reported opinions in broader contexts, including career and sexual well-being, to better understand patients' experiences with their cutaneous scars. Read More

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The effect of inhibiting exosomes derived from adipose-derived stem cells via the TGF-β1/Smad pathway on the fibrosis of keloid fibroblasts.

Gland Surg 2021 Mar;10(3):1046-1056

Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Background: The main mechanism of keloid formation is that keloid fibroblasts (KFs) apoptosis is inhibited, leading to excessive proliferation. Transforming growth factor-β1 (TGF-β1) is a key signal molecule in the process of regulating cell fibrosis. This paper discusses the effect of adipose-derived stem cell exosomes (ADSCs-EXO) on the proliferation and apoptosis of KFS and its possible mechanism, in order to provide reference for the clinical intervention of hypertrophic scar. Read More

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Treatment of Small Keloids Using Intralesional 5-fluorouracil and Triamcinolone Acetonide versus Intralesional Bleomycin and Triamcinolone Acetonide.

J Clin Aesthet Dermatol 2021 Mar 1;14(3):17-21. Epub 2021 Mar 1.

Drs. Sharma and Vinay are with the Department of Dermatology, Venereology, and Leprosy at the Sri Guru Ram Das Institute of Medical Sciences & Research in Amritsar, Punjab, India.

The aberration of wound healing leads to scar formation in the form of hypertrophic scars and keloids. Various modalities with variable results have been used in the treatment of keloids. We sought to evaluate outcomes in the treatment of small keloids with the combination of intralesional 5-fluorouracil (5-FU) and triamcinolone acetonide versus intralesional bleomycin and triamcinolone acetonide. Read More

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The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis.

Burns 2021 Feb 24. Epub 2021 Feb 24.

The Graduate School, Fujian Medical University, Fuzhou, China.

Background: Triamcinolone acetonide (TAC) is widely used for hypertrophic scars and keloids; however, TAC has variable efficacy and safety in different individuals.

Purpose: To evaluate the efficacy and safety of intralesional TAC for treatment of hypertrophic scars and keloids.

Data Sources: Searches of PubMed, EMBASE, the Cochrane Library, and ClinicalTrials. Read More

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February 2021

Scoping Review of Therapeutic Strategies for Keloids and Hypertrophic Scars.

Plast Reconstr Surg Glob Open 2021 Mar 22;9(3):e3469. Epub 2021 Mar 22.

Department of Surgery, Division Plastic and Reconstructive Surgery, University of Colorado School of Medicine, Denver, Colo.

Background: Keloids are an abnormal proliferation of scars that can involve large areas of tissue beyond the original injury site. Hypertrophic scars are similar clinically, but do not exceed the original scar limits. These scarring abnormalities can cause noxious symptoms such as pain, tenderness, itching, and ulcerations. Read More

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Warburg effect in keloids: A unique feature different from other types of scars.

Burns 2021 Mar 14. Epub 2021 Mar 14.

Ninth Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Keloid fibroblasts (KFs) undergo reprogramming of the metabolic phenotype from oxidative phosphorylation to the Warburg effect. However, more studies are needed to demonstrate whether there is a Warburg effect in KFs and to determine whether there is a similar phenomenon in other types of scars or in the proliferative stage of scars. In our study, the mRNA and protein expression of key glycolytic enzymes, glucose consumption and lactate production in KFs, normal skin fibroblasts (NFs), atrophic scar fibroblasts (ASFs), proliferative stage scar fibroblasts (PSSFs), and hypertrophic scar fibroblasts (HSFs) were detected. Read More

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Management of keloid scars: noninvasive and invasive treatments.

Sang Wha Kim

Arch Plast Surg 2021 Mar 15;48(2):149-157. Epub 2021 Mar 15.

Department of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Scars vary from mature linear scars to abnormal excessive scars such as hypertrophic scars and keloid scars. Keloid scars are fibro-proliferative disease entities that reflect an abnormal process of wound healing. They can cause pain, itching, stiffness, and psychological distress, all of which can affect quality of life. Read More

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A systematic review of randomised controlled trials investigating laser assisted drug delivery for the treatment of keloid and hypertrophic scars.

Lasers Med Sci 2021 Mar 24. Epub 2021 Mar 24.

Department of Dermatology, Westmead Hospital, Sydney, NSW, Australia.

The objective of this article is to study the clinical efficacy and adverse events of laser-assisted drug delivery in the treatment of hypertrophic and keloid scars. We searched the following databases up to 22 October 2020: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (Clinical Trials) in The Cochrane Library, MEDLINE, EMBASE, and reference lists of articles for randomised clinical trials (RCTs) of laser-assisted drug delivery for the treatment of hypertrophic and keloid scars. We also searched online trials registries for ongoing trials and contacted trial authors where appropriate. Read More

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Strontium-90 brachytherapy following intralesional triamcinolone and 5-fluorouracil injections for keloid treatment: A randomized controlled trial.

PLoS One 2021 23;16(3):e0248799. Epub 2021 Mar 23.

Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.

Background: Keloid disease is hard to fully eradicate. Recurrence and other unsatisfactory results were found in many patients. No current therapeutic modality has been determined to be most effective for treating keloid scars. Read More

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Attenuation of Abnormal Scarring Using Spherical Nucleic Acids Targeting Transforming Growth Factor Beta 1.

ACS Appl Bio Mater 2020 Dec 13;3(12):8603-8610. Epub 2020 Nov 13.

Department of Chemical and Biological Engineering, International Institute for Nanotechnology, Department of Materials Science and Engineering, and Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, United States.

Abnormal scarring is a consequence of dysregulation in the wound healing process, with limited options for effective and noninvasive therapies. Given the ability of spherical nucleic acids (SNAs) to penetrate skin and regulate gene expression within, we investigated whether gold-core SNAs (AuSNAs) and liposome-core SNAs (LSNAs) bearing antisense oligonucleotides targeting transforming growth factor beta 1 (TGF-1) can function as a topical therapy for scarring. Importantly, both SNA constructs appreciably downregulated TGF-1 protein expression in primary hypertrophic and keloid scar fibroblasts in vitro. Read More

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December 2020

Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling.

Int J Mol Sci 2021 Feb 23;22(4). Epub 2021 Feb 23.

Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan-si 31151, Korea.

Keloid and hypertrophic scars are skin fibrosis-associated disorders that exhibit an uncontrollable proliferation of fibroblasts and their subsequent contribution to the excessive accumulation of extracellular matrix (ECM) in the dermis. In this study, to elucidate the underlying mechanisms, we investigated the pivotal roles of epidermal growth factor (EGF) in modulating fibrotic phenotypes of keloid and hypertrophic dermal fibroblasts. Our initial findings revealed the molecular signatures of keloid dermal fibroblasts and showed the highest degree of skin fibrosis markers, ECM remodeling, anabolic collagen-cross-linking enzymes, such as lysyl oxidase (LOX) and four LOX-like family enzymes, migration ability, and cell-matrix traction force, at cell-matrix interfaces. Read More

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February 2021

Blood perfusion in hypertrophic scars and keloids studied by laser speckle contrast imaging.

Skin Res Technol 2021 Mar 2. Epub 2021 Mar 2.

Department of Plastic and Burn Surgery, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Background: This study used laser speckle contrast imaging (LSCI) to evaluate the difference in blood perfusion between hypertrophic scars and keloids.

Materials And Methods: A total of 30 keloids, 21 early hypertrophic scars, 20 proliferative hypertrophic scars, 20 regressive hypertrophic scars, and 20 mature hypertrophic scars were enrolled into this study. Vancouver Scar Scale (VSS) was assessed by a plastic surgeon. Read More

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Laser treatment of specific scar characteristics in hypertrophic scars and keloid: A systematic review.

J Plast Reconstr Aesthet Surg 2021 01 20;74(1):48-64. Epub 2020 Sep 20.

Department of Plastic, Reconstructive and Hand Surgery, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands. Electronic address:

Background: Hypertrophic scarring and keloid can cause significant emotional and physical discomfort. Cosmetic appearance, functional limitations, pain and pruritus form a degree of impairment. While the etiology is not fully known, there is a wide array of treatment options, which include excision, radiation, cryotherapy, silicone gel sheeting, and intralesional injections. Read More

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January 2021

Prophylactic external beam radiation therapy for keloid prevention in thyroid surgery patients.

Gland Surg 2021 Jan;10(1):65-72

Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA.

Background: Poor cosmesis, secondary to keloid or hypertrophic scar, following thyroid surgery may cause considerable patient distress and be a significant challenge to treat. In this case series we examined the efficacy of prophylactic external beam radiation therapy (EBRT) for prevention of keloid formation in keloid-prone patients undergoing thyroid surgery. While much has been published about documenting the efficacy in reducing keloid formation following keloid excision, very little literature exists documenting prophylactic use related to surgeries with the goal of prevent keloid formation. Read More

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January 2021

Safety assessment of the prophylactic use of silicone gel sheets (Lady Care) for the prevention of hypertrophic scars following caesarean section.

J Obstet Gynaecol 2021 Apr 26;41(3):380-384. Epub 2021 Feb 26.

Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.

This study aimed to investigate the side effects of silicone gel sheet (Lady Care) and evaluate its prophylactic efficacy in preventing abnormal scarring. Sixty women who underwent caesarean section were recruited from September 2016 to September 2017 in this prospective study. Lady Care was applied from the 2nd to the 6th postoperative months. Read More

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Inhibitory Effect of the LY2109761 on the Development of Human Keloid Fibroblasts.

Anal Cell Pathol (Amst) 2021 10;2021:8883427. Epub 2021 Feb 10.

Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.

Keloids are scars characterized by abnormal proliferation of fibroblasts and overproduction of extracellular matrix components including collagen. We previously showed that LY2109761, a transforming growth factor- (TGF-) receptor inhibitor, suppressed the secretion of matrix components and slowed the proliferation of fibroblasts derived from human hypertrophic scar tissue. However, the exact mechanism underlying this effect remains unclear. Read More

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February 2021

[Bibliometric and visual analysis of current status and trends of international research on keloids].

Zhonghua Shao Shang Za Zhi 2021 Mar;37(3):263-270

Department of Plastic Surgery and Burns, First Hospital of Shanxi Medical University, Taiyuan 030001,China.

To conduct a bibliometric and visual analysis of the current status and trends of international research on keloids. The articles on keloid research from 2000 to 2020 in the core collection of database were retrieved. The bibliometrics method was applied to analyze the number of articles published per year, journals and the first authors, countries and institutions, research fields, the annual citation frequency of cumulative published articles, highly cited articles, keywords. Read More

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Adverse Effects of Pregnancy on Keloids and Hypertrophic Scars.

Cureus 2020 Dec 18;12(12):e12154. Epub 2020 Dec 18.

Plastic Surgery, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, GBR.

There are many well-known risk factors for keloids and hypertrophic scars (HTS) including ethnicity, family history, and history of previous keloids or HTS. An association, which has been previously observed, exists between pregnancy and growth and worsening of keloid and HTS. This association is less well known amongst physicians and less documented in the literature. Read More

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December 2020

Association between MeCP2 and Smad7 in the pathogenesis and development of pathological scars.

J Plast Surg Hand Surg 2021 Jan 21:1-14. Epub 2021 Jan 21.

Department of Plastic and Burn Surgery, Chongqing Medical University First Affiliated Hospital, Chongqing, China.

To explore the relationship between methylated binding protein 2 (MeCP2) and mothers against decapentaplegic homolog 7 (Smad7) in the pathogenesis and development of pathological scars. Immunohistochemistry, Western blot and real-time polymerase chain reaction (RT-PCR) were used to detect the expression of MeCP2 in different types of human scars and hypertrophic scars at different growth times. The methylation status of Smad7 gene promoter in different scar tissues was determined by methylation-specific PCR. Read More

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January 2021

Adipose-derived mesenchymal stem cells inhibit cell proliferation and migration and suppress extracellular matrix synthesis in hypertrophic-scar and keloid fibroblasts.

Exp Ther Med 2021 Feb 14;21(2):139. Epub 2020 Dec 14.

Cranio-Maxillo-Facial Surgery Department 2, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China.

Pathological scars occur during skin wound healing, and the use of adipose-derived stem cells (ADSCs) is one of the various treatments. The present study aimed to investigate the effects of ADSCs on the biological properties of hypertrophic scar fibroblasts (HSFs) and keloid fibroblasts (KFs), such as proliferation, migration, and the synthesis of extracellular matrix proteins. Transwell chambers were used to establish a co-culture system of ADSCs with normal skin fibroblasts (NFs), HSFs or KFs. Read More

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February 2021

Scar tissue I wish you saw: Patient expectations regarding scar treatment.

J Cosmet Dermatol 2021 Jan 12. Epub 2021 Jan 12.

Department of Dermatology, New York Medical College, New York, NY, USA.

Although many invasive and noninvasive approaches exist, management of keloids and hypertrophic scars remains challenging. By better understanding patient expectations regarding scar treatments, dermatologists can provide higher quality and more satisfying care. Survey patients age 18 to 80 years with a history of hypertrophic, keloid, or disfiguring scars. Read More

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January 2021