1,190 results match your criteria Keloid and Hypertrophic Scar

Concomitant therapy of surgical shave excision and intralesional injections for ear keloids: Early results from a retrospective cohort study.

Scars Burn Heal 2022 Jan-Dec;8:20595131221098531. Epub 2022 May 11.

Institute of Cosmetic and Laser Surgery, Oakville, Canada.

Introduction: Keloids are hypertrophic scars that commonly arise in the ear region. The authors' objectives were to (1) evaluate effectiveness of surgical shave excision followed by intralesional triamcinolone acetonide and onabotulinumtoxinA injections; and (2) evaluate safety and patient satisfaction.

Methods And Materials: This study was a retrospective chart review of patients who received treatment of extralesional surgical shave excision followed by intralesional triamcinolone acetonide and onabotulinumtoxinA injections to treat ear keloids at a single outpatient dermatology clinic. Read More

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Aesthetic Reconstruction of Auricular Keloids with a Novel Hemi-keystone Flap.

Tae Hwan Park

Aesthetic Plast Surg 2022 May 12. Epub 2022 May 12.

Department of Plastic and Reconstructive Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 40, Seokwoo-Dong, Hwaseong, 18450, Republic of Korea.

Surgical management of helical and retroauricular keloids has been rarely discussed. This study aims to introduce our successful reconstruction of helical and retroauricular keloids using a novel hemi-keystone flap. The current study is a retrospective review of patients with pathologically confirmed helical and retroauricular keloids. Read More

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Immunohistochemical Expression of Axin-2, as an Implication of the Role of Stem Cell in Scar Pathogenesis and Prognosis.

J Cosmet Dermatol 2022 May 12. Epub 2022 May 12.

Department of Dermatology, Andrology and STDS, Faculty of Medicine, Menoufia University, Egypt.

Background: Wound healing is a multi-phased process. A disruption in these phases could result in a persistent wound or an atypical scar. Wounding activates wingless proteins (Wnt) signalling, which aids in the healing process. Read More

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The role of altered fatty acid in pathological scars and their dermal fibroblasts.

Chin J Traumatol 2022 Apr 2. Epub 2022 Apr 2.

7th Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China. Electronic address:

Purpose: The proposed pathological mechanism for scar formation is controversial, and increased attention has been paid to the fatty acids (FAs) in the formation of pathological scars. Notably, FAs are known to be important in inflammation and mechanotransduction, which is closely related to scar formation. Therefore, it is necessary to clarify the roles of FA in scar formation. Read More

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Krox20 expression in abnormal scars: An immunohistochemical study.

J Cosmet Dermatol 2022 Apr 13. Epub 2022 Apr 13.

Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Shebin El Kom, Egypt.

Background: Scars are the end outcome of healing. They are grouped into several types, the common of which are keloids, hypertrophic, and atrophic scars. The role of Krox20 in skin and hair physiology and pathology had emerged. Read More

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Epigenetic Influences on Wound Healing and Hypertrophic-Keloid Scarring: A Review for Basic Scientists and Clinicians.

Cureus 2022 Mar 26;14(3):e23503. Epub 2022 Mar 26.

Pathophysiology, American University of Antigua, Coolidge, ATG.

Primary care physicians and dermatologists are challenged by patients affected by keloid or hypertrophic scarring resulting from accidental wounding, surgical incisions, tattooing, or "branding" procedures to demonstrate their association with a specific culture, fraternity, or cult. The dysregulated wound healing associated with keloids and hypertrophic scarring adversely affects genetically susceptible individuals, especially persons of color with Fitzpatrick Skin types IV-VI. Although the specific mechanisms of bulky hypertrophic/keloid scarring and its association with oxidative stress and inflammation remain unclear, the current knowledge base is sufficient to provide some guidance to health practitioners who must serve, treat, and counsel affected individuals. Read More

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The use of fluid silicone gels in the prevention and treatment of hypertrophic scars: a systematic review and meta-analysis.

Burns 2022 May 17;48(3):491-509. Epub 2022 Mar 17.

Burn Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium; Department of Plastic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.

Background: Silicone products, either as a sheet or in fluid form, are universally considered as the first line therapy in the prevention and treatment of hypertrophic scars and keloids. However, the study results have been questioned by different authors and there has never been a large systematic synopsis published on the efficacy of fluid silicone gels. This systematic review aims to elucidate the available evidence of the results obtained by fluid silicone gels and present a complete and comprehensive overview of the available literature as well as a meta-analysis of the pooled data. Read More

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Nuclear medicine in the management of superficial skin abnormalities and institutional experience.

Nucl Med Commun 2022 Jun 1;43(6):625-630. Epub 2022 Apr 1.

Departments ofNuclear Medicine.

Keloid, hypertrophic scars and basal cell carcinoma (BCC) falls under the category of non-melanoma skin cancer. Intralesional steroids, external beam radiation therapy, 5-Fluorouracil, cryotherapy, laser, etc are the available treatment options. However, recurrence has been reported with each type of treatment mode. Read More

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Schwann cells contribute to keloid formation.

Matrix Biol 2022 04 10;108:55-76. Epub 2022 Mar 10.

Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address:

Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms, which could lead to severe functional impairments. Here we analyzed the characteristics of keloidal cells by single cell sequencing and discovered the presence of an abundant population of Schwann cells that persisted in the hypertrophic scar tissue after wound healing. In contrast to normal skin, keloidal Schwann cells show a unique, pro-fibrotic phenotype. Read More

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Surgical Considerations In Skin of Colour.

Ebube Obi

Clin Exp Dermatol 2022 Feb 20. Epub 2022 Feb 20.

Department of Opthalmology, Aneurin Bevan University Health Board, Newport, UK.

For most clinicians undertaking surgery and patients undergoing surgery, the primary aim is the success of the operation being undertaken. The secondary aim is for optimal wound healing with minimal scar formation. The normal wound healing process involves four distinct but overlapping stages: Haemostasis, inflammation, proliferation and remodelling. Read More

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February 2022

LARP6 Regulates Keloid Fibroblast Proliferation, Invasion, and Ability to Synthesize Collagen.

J Invest Dermatol 2022 Feb 15. Epub 2022 Feb 15.

Department of Burns and Plastic Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. Electronic address:

Keloid is a skin fibroproliferative disease currently having no uniformly successful treatment. The lesion is composed of actively proliferating and collagen-overproducing fibroblasts. LARP6 is an RNA-binding protein able to regulate collagen synthesis in fibroblasts and to promote proliferation and invasion of tumor cells. Read More

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February 2022

Management of hypertrophic scars in adults: A systematic review and meta-analysis.

Australas J Dermatol 2022 May 31;63(2):172-189. Epub 2022 Jan 31.

Toronto Dermatology Centre, North York, Ontario, Canada.

Hypertrophic scars (HTS) are elevated scars which occur due to abnormalities in wound healing after injury and may be associated with pain, pruritus and functional impairment. Despite multiple available treatment options, there is no universal approach to treating HTS. We searched the Web of Science (Core Collection), MEDLINE and EMBASE databases. Read More

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Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid.

Front Cell Dev Biol 2021 6;9:823694. Epub 2022 Jan 6.

Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Hypertrophic scars or keloid form as part of the wound healing reaction process, and its formation mechanism is complex and diverse, involving multi-stage synergistic action of multiple cells and factors. Adipose stem cells (ASCs) have become an emerging approach for the treatment of many diseases, including hypertrophic scarring or keloid, owing to their various advantages and potential. Herein, we analyzed the molecular mechanism of hypertrophic scar or keloid formation and explored the role and prospects of stem cell therapy, in the treatment of this condition. Read More

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January 2022

Efficacy of the Neodymium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Keloid and Hypertrophic Scars: A Systematic Review and Meta-analysis.

Aesthetic Plast Surg 2022 Jan 21. Epub 2022 Jan 21.

Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, Jilin, 130033, People's Republic of China.

Background: Keloid and hypertrophic scars are the most common types of pathological scars. They can cause itching, pain, erythema, and psychological stress due to cosmetic problems, decreasing the quality of life for affected individuals. The neodymium-doped yttrium aluminum garnet (Nd:YAG) multipurpose laser is used to treat pathological scars, and studies have shown that the Nd:YAG laser can markedly improve scarring. Read More

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January 2022

To Explore Ideas From the Altered Metabolites: The Metabolomics of Pathological Scar.

J Craniofac Surg 2022 Jan 18. Epub 2022 Jan 18.

7th Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Department of Burn and Plastic Surgery, the Fourth Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China.

Background: Pathological scars are dermal fibroproliferative disorders due to rapid inflammatory response after dermal injury. The altered metabolites could reflect pathophysiological changes directly. However, it has not cleared how the metabolites change scars. Read More

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January 2022

Downregulated cytotoxic CD8 T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids.

Cell Mol Immunol 2022 Apr 17;19(4):527-539. Epub 2022 Jan 17.

Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Keloids are an abnormal fibroproliferative wound-healing disease with a poorly understood pathogenesis, making it difficult to predict and prevent this disease in clinical settings. Identifying disease-specific signatures at the molecular and cellular levels in both the blood circulation and primary lesions is urgently needed to develop novel biomarkers for risk assessment and therapeutic targets for recurrence-free treatment. There is mounting evidence of immune cell dysregulation in keloid scarring. Read More

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[Gynaecomastia and adipomastia on black skin: Clinical and surgical particularity].

Ann Chir Plast Esthet 2022 Jan 12. Epub 2022 Jan 12.

Service d'urologie - andrologie, CHU Sylvanus Olympio, Lomé, Togo.

Aim: Analyze the management of gynecomastia and adipomastia; and identify the peculiarities in black people in a general surgery department of the CHU Sylvanus Olympio in Lomé (Togo).

Patient And Method: Descriptive retrospective study included 43 cases of gynecomastia and 5 cases of adipomastia (January 2014 to December 2020). The data taken into account were: epidemiological, clinical, paraclinical and the treatment (surgery and medical). Read More

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January 2022

Complication Rates From Otoplasty at a Tertiary Facial Plastic Surgery Center: A Retrospective Analysis.

J Craniofac Surg 2022 Jan 10. Epub 2022 Jan 10.

Otolaryngology and Head & Neck, Facial Plastic, Ministry of Health & King Saud University King Abdulaziz University Hospital (KAUH) Otolaryngology and Head & Neck Resident, Ministry of Health Otolaryngology and Head & Neck, Facial Plastic, Dr. Sulaiman AlHabib Medical Group Otolaryngology and Head & Neck - Facial Plastic, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Abstract: Prominent ears are considered the most common congenital external ear deformity among Caucasians. Affecting approximately 5% of the population, it runs in families and exhibits equal sex incidence. This study aimed to determine the complication rate from otoplasty in a tertiary facial plastic surgery center. Read More

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January 2022

Plasma Radiofrequency Ablation for Scar Treatment.

J Clin Med 2021 Dec 27;11(1). Epub 2021 Dec 27.

Plastic Surgery Unit, University of Campania "Luigi Vanvitelli", 80120 Napoli, Italy.

Scars are a common disfiguring sequela of various events such as acne, hidradenitis suppurativa, surgery, trauma, and burns, which can lead to serious psychosocial problems with a negative effect on the quality of life. Many conventional approaches have been proposed for the treatment of scars, including surgical techniques, dermabrasion, chemical peels, topical silicone gel, 5-fluorouracile and dermal fillers injection or autologous fat transfer for atrophic scars, and corticosteroids injection for hypertrophic and keloid scars; however, they have sporadic effects. Ablative lasers, such as carbon dioxide laser or Erbium Yag laser, are associated with many collateral effects limiting their application. Read More

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December 2021

Non-Invasive and Surgical Modalities for Scar Management: A Clinical Algorithm.

J Pers Med 2021 Nov 29;11(12). Epub 2021 Nov 29.

Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Medical School Hannover, 30625 Hannover, Germany.

Scars can lead to aesthetic and functional impairments. The treatment of scars requires meticulous planning and an individually adapted therapeutic strategy. A conceptual algorithm for scar treatment makes everyday clinical work easier for the practitioner and offers more safety for the patient. Read More

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November 2021

[Several problems worthy of attention in non-surgical treatment of scar].

Y Liu

Zhonghua Shao Shang Za Zhi 2021 Dec;37(12):1194-1198

Department of Burns and Plastic Surgery & Wound Repair Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China.

Pathologically, scars are divided into physiological scars and pathological scars, and the latter mainly include hyperplastic scars and keloids. Scar treatment includes surgical treatment and non-surgical treatment, with the pathological scars as the major targets in treatment. Until now, there is no treatment with ideal therapeutic effect. Read More

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December 2021

, , and Approaches for Investigation of Skin Scarring: Human and Animal Models.

Adv Wound Care (New Rochelle) 2022 Feb 2. Epub 2022 Feb 2.

Plastic & Reconstructive Surgery Research, Centre for Dermatology Research, Wound Healing Theme, NIHR Manchester Biomedical Research Centre, University of Manchester, Manchester, England, United Kingdom.

The cutaneous repair process naturally results in different types of scarring that are classified as normal or pathological. Affected individuals are often affected from an esthetic, physical (functional), and psychosocial perspective. The distinct nature of scarring in humans, particularly the formation of pathological scars, makes the study of skin scarring a challenge for researchers in this area. Read More

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February 2022

Efficacy and safety of thermomechanical fractional injury-assisted corticosteroid delivery versus intralesional corticosteroid injection for the treatment of hypertrophic scars: A randomized split-scar trial.

Lasers Surg Med 2022 04 16;54(4):483-489. Epub 2021 Dec 16.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Disruption of the natural skin barrier in a controlled manner may be used to deliver drugs that enhance scar resolution.

Objective: To compare the efficacy and safety of thermomechanical fractional injury (TMFI)-assisted topical corticosteroid delivery with corticosteroid injection in the treatment of hypertrophic scar (HTS).

Materials And Methods: This was a randomized, split-scar, double-blinded study. Read More

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Correlation between elastic modulus and clinical severity of pathological scars: a cross-sectional study.

Sci Rep 2021 12 2;11(1):23324. Epub 2021 Dec 2.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Though widely used to assess pathological scars, the modified Vancouver Scar Scale (mVSS) is neither convenient nor objective. Shear wave elastography (SWE) is used to evaluate the stiffness of pathological scars. We aimed to determine the correlation between mVSS score and elastic modulus (EM) measured by SWE for pathological scars. Read More

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December 2021

The Most Current Algorithms for the Treatment and Prevention of Hypertrophic Scars and Keloids: A 2020 Update of the Algorithms Published 10 Years Ago.

Rei Ogawa

Plast Reconstr Surg 2022 Jan;149(1):79e-94e

From the Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School.

Background: In 2010, this Journal published my comprehensive review of the literature on hypertrophic scars and keloids. In that article, I presented evidence-based algorithms for the prevention and treatment of these refractory pathologic scars. In the ensuing decade, substantial progress has been made in the field, including many new randomized controlled trials. Read More

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January 2022

Is Hypertrophic or Keloid Wound Scar a Risk Factor for Stricture at Esophagogastric Anastomosis Site after Esophageal Cancer Operation?

Korean J Gastroenterol 2021 10;78(4):213-218

Department of Thoracic and Cardiovascular Surgery, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

Background/aims: Anastomotic stricture at the esophagus and the conduit anastomosis site after the surgical resection of esophageal cancer is relatively common. This study examined whether a hypertrophic scar or keloid formation at a surgical wound is related to an anastomotic stricture.

Methods: From March 2007 to July 2017, 59 patients underwent curative surgery for esophageal cancer. Read More

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October 2021

A Methylome and Transcriptome Analysis of Normal Human Scar Cells Reveals a Role for FOXF2 in Scar Maintenance.

J Invest Dermatol 2022 May 21;142(5):1489-1498.e12. Epub 2021 Oct 21.

Burn Injury Research Unit, School of Biomedical Sciences, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Australia.

Scars are maintained for life and increase in size during periods of growth such as puberty. Epigenetic changes in fibroblasts after injury may underpin the maintenance and growth of scars. In this study, we combined methylome and transcriptome data from normotrophic mature scar and contralateral uninjured normal skin fibroblasts to identify potential regulators of scar maintenance. Read More

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Molecular Features of Hypertrophic Scars After Thermal Injury: Is There a Biologic Basis for Laser Therapy?

Adv Wound Care (New Rochelle) 2022 04 22;11(4):163-178. Epub 2021 Dec 22.

Wound Healing Research Group, Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Alberta, Edmonton, Canada.

Hypertrophic scars (HTS) and keloids are common after thermal injuries and other trauma to deep regions of dermis of the skin. These abnormal scars can cause contractures and the thick masses of scar tissue that result in functional and cosmetic impairment. Management of these dermal fibrotic conditions includes a wide range of medical and surgical treatments, which can be time consuming, only partially effective, and often uncomfortable for patients. Read More

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The effectiveness of long Pulsed Nd:YAG Laser alone for treatment of keloids and hypertrophic scars versus its combination with bleomycin.

J Cosmet Dermatol 2021 Dec 18;20(12):3899-3906. Epub 2021 Oct 18.

Dermatology Unit, Medical Application Of Laser (MAL) Department, National Institute of laser and Enhanced Sciences, Cairo University, Giza, Egypt.

Background And Objectives: Pathological scars are benign hyper-proliferative growths of dermal collagen that causes severe psychological and physical problems. This study was performed to assess and compare safety and clinical efficiency of combined pulsed Nd-YAG laser and intralesional bleomycin versus pulsed Nd-YAG laser alone to treat the hypertrophic scars and keloids.

Patients And Methods: Randomly, 40 patients with hypertrophic scars or keloids were divided into two groups A and B. Read More

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December 2021

Network Meta-Analysis of Different Clinical Commonly Used Drugs for the Treatment of Hypertrophic Scar and Keloid.

Front Med (Lausanne) 2021 9;8:691628. Epub 2021 Sep 9.

Department of Orthopaedics, Children's Hospital of Chongqing Medical University, Chongqing, China.

There is no uniform treatment for pathological scars, including keloids and hypertrophic scars, in clinic currently. Previously, multiple randomized controlled trials have examined the clinical efficacy of different treatments. Nonetheless, the results are inconsistent, and many treatments have not been directly compared. Read More

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September 2021