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    10334 results match your criteria Kawasaki Disease

    1 OF 207

    Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey in Japan.
    J Pediatr 2017 Dec 7. Epub 2017 Dec 7.
    Japan Society of Kawasaki Disease, Tokyo, Japan.
    Objective: To assess the safety and efficacy of infliximab (IFX) for the treatment of patients with Kawasaki disease (KD).

    Study Design: This was a nationwide survey of 274 Japanese institutions exploring how IFX was used to treat patients with KD. The patients' sex, age, treatment course, pre- and post-IFX therapy blood test results, coronary artery lesions (CALs), and adverse events (AEs) were evaluated. Read More

    Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats.
    PLoS One 2017 8;12(12):e0189099. Epub 2017 Dec 8.
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido, Gifu, Japan.
    Objective: A high salt intake causes hypertension and leads to cardiovascular disease. Therefore, a low salt diet is now recommended to prevent hypertension and cardiovascular disease. However, it is still unknown whether an excessively low salt diet is beneficial or harmful for the heart. Read More

    Characteristics and outcome of intractable vasculitis syndrome in children: Nation-wide survey in Japan.
    Mod Rheumatol 2017 Dec 8:1-6. Epub 2017 Dec 8.
    a Department of Pediatrics , Ehime University Graduate School of Medicine , Ehime , Japan.
    Objective: Primary systemic vasculitis (PSV) is a rare disorder in children and difficult to distinguish from other diseases. However, appropriate diagnosis and prompt treatment will affect on the morbidity and mortality of intractable PSV. In this study, we conducted a nationwide survey in Japan, to clarify epidemiology and clinical outcome of PSV. Read More

    A long-surviving patient with advanced esophageal basaloid squamous cell carcinoma treated only with radiotherapy: case report and literature review.
    BMC Gastroenterol 2017 Dec 8;17(1):151. Epub 2017 Dec 8.
    Department of Radiation Oncology, Kawasaki Saiwai Hospital, Kawasaki, Kanagawa, 212-0014, Japan.
    Background: Esophageal basaloid squamous cell carcinoma (EBSCC) is a rare malignant disease. Advanced EBSCC (AEBSCC) has a poorer prognosis than the more common esophageal squamous cell carcinoma, but no treatment policy has yet been established. This is the first reported case with AEBSCC treated only with radiotherapy. Read More

    ITPKC and SLC11A1 Gene Polymorphisms and Gene-Gene Interactions in Korean Patients with Kawasaki Disease.
    Yonsei Med J 2018 Jan;59(1):119-127
    Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea.
    Purpose: Kawasaki disease (KD) is an acute systemic vasculitis. Both the etiology of KD and the erythema of Bacille Calmette-Guérin (BCG) injection sites observed in the disease are poorly understood. We investigated the association between KD and single nucleotide polymorphisms (SNPs) in two candidate genes: inositol 1,4,5-triphosphate 3-kinase (ITPKC), a well-studied KD-associated gene, and solute carrier 11a1 (SLC11A1), which is associated with the hypersensitive reaction to the BCG strain in Koreans. Read More

    Clinical Outcomes of Low-Dose Methotrexate Therapy as a Second-Line Drug for Intravenous Immunoglobulin-Resistant Kawasaki Disease.
    Yonsei Med J 2018 Jan;59(1):113-118
    Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea.
    Purpose: Intravenous immunoglobulin (IVIG) is the standard treatment for Kawasaki disease (KD). However, there is still no standard treatment for IVIG-resistant KD. This study aimed to evaluate the efficacy of low-dose methotrexate (MTX) as a treatment for IVIG-resistant KD. Read More

    Review: surgical treatment of giant coronary aneurysms in pediatric patients with Kawasaki disease.
    Gen Thorac Cardiovasc Surg 2017 Dec 6. Epub 2017 Dec 6.
    Nippon Medical School, 1-56-11 Kitasenzoku Ohta-ku, Tokyo, 145-0062, Japan.
    In Kawasaki disease (KD), giant coronary aneurysms in the proximal segments of the coronary arteries have long been among the serious complications associated with acute myocardial infarction. To treat myocardial ischemia in children, Kitamura et al. first performed coronary artery bypass grafting in a pediatric patient using an autologous saphenous vein. Read More

    Intrauterine and Early Postnatal Exposure to Particulate Air Pollution and Kawasaki Disease: A Nationwide Longitudinal Survey in Japan.
    J Pediatr 2017 Dec 4. Epub 2017 Dec 4.
    Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
    Objectives: To examine the effects of prenatal and postnatal exposure to particulate matter on Kawasaki disease (KD) occurrence, using data from a nationwide population-based longitudinal survey in Japan that began in 2010.

    Study Design: Prenatal and postnatal suspended particulate matter concentrations were obtained at municipality level and assigned to participants based on their municipality of birth. We analyzed data from 30 367 participants with data on either exposure period. Read More

    Stenotic Lesions and the Maximum Diameter of Coronary Artery Aneurysms in Kawasaki Disease.
    J Pediatr 2017 Dec 4. Epub 2017 Dec 4.
    Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
    Objectives: To determine the prevalence of subsequent stenotic lesions based on the maximum diameter of the largest coronary artery aneurysm in patients with Kawasaki disease and the threshold value of coronary artery diameter associated with risk of developing stenotic lesion.

    Study Design: There were 214 patients (160 males) who had at least 1 aneurysm in a selective coronary angiogram (CAG) done <100 days after the onset of Kawasaki disease were studied. We measured the maximal coronary artery aneurysm diameter in 3 major branches in the initial CAGs. Read More

    Autoimmune and medication-induced lymphadenopathies.
    Semin Diagn Pathol 2017 Nov 28. Epub 2017 Nov 28.
    Department of Hematopathology, M.D. Anderson Cancer Center Houston, TX, USA.
    This article will provide a discussion of some common autoimmune disorders that could affect the lymph nodes and potentially mimic B and T-cell lymphomas. Some of these disorders are more characteristic of individuals in the pediatric age group (autoimmune lymphoproliferative syndrome, Kawasaki disease), while others present in older individuals (rheumatoid arthritis, lupus erythematosus, sarcoidosis). A common finding that groups all of these disorders together is the overall relative preservation of the architecture, a feature that can be particularly helpful to distinguish them from many B and T-cell lymphomas. Read More

    Young Athlete With Complex Aneurysmal Coronary Stenosis.
    J Invasive Cardiol 2017 Dec;29(12):E197-E198
    Emory University School of Medicine, 49 Jesse Hill Jr. Drive SE, Atlanta, GA 30303 USA.
    Kawasaki disease is an acute vasculitis that occurs predominantly in infants and children younger than 5 years old. If undiagnosed and untreated, the risk of developing coronary artery aneurysms increases to about 20%. In patients who present with angina and are found to have coronary artery aneurysm on imaging and angiography, Kawasaki disease should be considered as one of the leading diagnoses. Read More

    Molecular basis of coronary artery dilation and aneurysms in patients with Kawasaki disease based on differential protein expression.
    Mol Med Rep 2017 Nov 20. Epub 2017 Nov 20.
    Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, P.R. China.
    Kawasaki disease (KD) is an acquired cardiac disease with a high incidence that affects children. KD has various complications, including coronary artery dilation (CAD) and coronary artery aneurysms (CAA). The identification of differentially expressed proteins and the underlying mechanisms may be the key to understanding differences between these KD complications. Read More

    Role of intravenous immunoglobulin in the treatment of Kawasaki disease.
    Int J Rheum Dis 2017 Dec 5. Epub 2017 Dec 5.
    Department of Pediatrics, Harvard Medical School, Boston, MA.
    Intravenous immunoglobulin (IVIg) is a purified plasma product that is used for many immune-deficient conditions and autoimmune conditions. Use of IVIg for treatment for Kawasaki disease (KD) is critical for control of inflammation. The American Heart Association (AHA) recommends a single infusion of 2 g/kg preferably given during the first 10 days of illness. Read More

    Computed Tomography Coronary Angiography for Evaluation of Children With Kawasaki Disease.
    Curr Probl Diagn Radiol 2017 Oct 23. Epub 2017 Oct 23.
    Department of Pediatrics, University of California San Diego (UCSD) School of Medicine and Rady Children's Hospital San Diego, La Jolla, CA.
    Objective: We sought to assess the feasibility of computed tomography coronary angiography (CTCA) on a 128-slice, dual source scanner in children with acute and convalescent phase Kawasaki disease (KD).

    Materials And Methods: A prospective study of 49 children with KD (12 at presentation and 37 in the convalescent phase) was conducted between November 2013 and April 2015. CTCA was performed with either prospective (n = 37) or retrospective (n = 12) electrocardiographic gating. Read More

    Cardiovascular Risk After Kawasaki Disease - Findings From an Australian Case-Control Study.
    Heart Lung Circ 2018 Jan;27(1):6-8
    Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Vic, Australia; Department of Paediatrics, University of Melbourne, Parkville, Vic, Australia; Department of Paediatrics, Monash University, Clayton, Vic, Australia. Electronic address:

    Kawasaki Disease Substantially Impacts Health-Related Quality of Life.
    J Pediatr 2017 Nov 30. Epub 2017 Nov 30.
    Division of Pediatric Cardiology, Department of Pediatrics, University of Washington, Seattle, WA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA.
    Objective: To prospectively evaluate the acute impact of Kawasaki disease (KD) on health-related quality of life (HRQoL) and to assess deterioration in the HRQoL experienced by children with KD compared with other childhood diseases.

    Study Design: We merged the Outcomes Assessment Program database obtained prospectively with the existing KD database and queried for KD admissions between 1 month and 13 years of age. HRQoL was evaluated with the parent-proxy Pediatric Quality of Life Inventory (PedsQL) 4. Read More

    Magnesium and Risk of Hip Fracture among Patients Undergoing Hemodialysis.
    J Am Soc Nephrol 2017 Nov 30. Epub 2017 Nov 30.
    Committee of Renal Data Registry, Japanese Society for Dialysis Therapy, Tokyo, Japan.
    Magnesium is an essential mineral for bone metabolism. However, little is known about the relationship between magnesium and the risk of fractures. In this cohort study, we elucidated the association between serum magnesium level and the risk of incident hip fracture among patients undergoing hemodialysis. Read More

    A phase II trial of carboplatin plus S-1 for elderly patients with advanced non-small-cell lung cancer with wild-type epidermal growth factor receptor: The Okayama Lung Cancer Study Group Trial 1202.
    Lung Cancer 2017 Oct 12;112:188-194. Epub 2017 Aug 12.
    Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
    Introduction: S-1 is an oral fluoropyrimidine-based combination of tegafur, gimeracil, and oteracil potassium. Although the combination of S-1 with carboplatin is a first-line chemotherapy regimen for advanced non-small cell lung cancer (NSCLC), the efficacy and safety of the regimen in the elderly remain unknown.

    Methods: The patient inclusion criteria were previously untreated advanced NSCLC, wild-type epidermal growth factor receptor, aged 70 years or more, and a performance status (PS) of 0-2. Read More

    Clinical strategy of diagnosing and following patients with nonalcoholic fatty liver disease based on invasive and noninvasive methods.
    J Gastroenterol 2017 Nov 24. Epub 2017 Nov 24.
    Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
    Nonalcoholic fatty liver disease (NAFLD) is an important cause of chronic liver injury in many countries. The incidence of NAFLD is rising rapidly in both adults and children, because of the currently ongoing epidemics of obesity and type 2 diabetes. Notably, histological liver fibrosis is recognized as the main predictive factor for the overall long-term outcome of NAFLD, including cardiovascular disease and liver-related mortality. Read More

    The Clinical Utility and Safety of a New Strategy for the Treatment of Refractory Kawasaki Disease.
    J Pediatr 2017 Dec;191:140-144
    Department of Pediatrics, Kitasato University, Kanagawa, Japan. Electronic address:
    Objective: To assess the clinical utility and safety of a strategy for refractory Kawasaki disease, defined by Egami score ≥3.

    Study Design: First-line treatment was with intravenous methylprednisolone (30 mg/kg, 2 hours, 1 dose) plus intravenous immunoglobulin (2 g/kg, 24 hours) treatment. Patients resistant to first-line treatment received additional intravenous immunoglobulin as a second-line treatment. Read More

    Factors Predicting Resistance to Intravenous Immunoglobulin Treatment and Coronary Artery Lesion in Patients with Kawasaki Disease: Analysis of the Korean Nationwide Multicenter Survey from 2012 to 2014.
    Korean Circ J 2017 Nov 9. Epub 2017 Nov 9.
    Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
    Background And Objectives: Approximately 10-15% of children with Kawasaki disease (KD) do not respond to initial intravenous immunoglobulin (IVIG) and have higher risk for coronary artery lesion (CAL). The aim of this study was to identify predictive factors from laboratory findings in patients who do not respond to IVIG treatment and develop CAL from KD.

    Methods: We retrospectively collected nationwide multicenter data from the Korean Society of Kawasaki Disease and included 5,151 patients with KD between 2012 and 2014 from 38 hospitals. Read More

    Predictive factors for emergent surgical intervention in patients with ovarian endometrioma hospitalized for pelvic inflammatory disease: A retrospective observational study.
    J Obstet Gynaecol Res 2017 Nov 24. Epub 2017 Nov 24.
    Department of Obstetrics and Gynecology, University Hospital, Mizonokuchi, Teikyo University School of Medicine, Kawasaki, Japan.
    Aim: The aim of this study was to identify predictive factors for emergent surgical interventions in patients with ovarian endometriomas hospitalized for pelvic inflammatory disease (PID).

    Methods: We retrospectively identified 22 patients with ovarian endometriomas who were hospitalized to manage PID. Patients were divided into two groups: those who required emergent surgery after failed antibiotic therapy (emergent surgery group, n = 6) and those who were discharged with successful antibiotic therapy (conservative group, n = 16). Read More

    Trends and predictors of non-cardiovascular death in patients hospitalized for acute heart failure.
    Int J Cardiol 2018 Jan;250:164-170
    Division of Cardiology and Intensive Care Unit, Nippon Medical School Musashi-Kosugi Hospital, 1-396 Kosugi-machi, Nakahara-ku, Kawasaki, Japan.
    Background: Little information is available on non-cardiovascular (CV) death in acute heart failure (AHF) patients. The present study determined the incidence, time course, and factors associated with long-term non-CV death in AHF patients in a real-world setting.

    Methods: The ATTEND registry, a nationwide, prospective observational multicenter cohort study, included 4842 consecutive patients hospitalized for AHF. Read More

    Role of chemotherapy and targeted therapy in early-stage non-small cell lung cancer.
    Expert Rev Anticancer Ther 2017 Nov 26:1-8. Epub 2017 Nov 26.
    c Department of Internal Medicine, Division of Hematology/Oncology , University of Michigan , Ann Arbor , MI , USA.
    Introduction: Adjuvant platinum based chemotherapy is accepted as standard of care in stage II and III non-small cell lung cancer (NSCLC) patients and is often considered in patients with stage IB disease who have tumors ≥ 4 cm. The survival advantage is modest with approximately 5% at 5 years. Areas covered: This review article presents relevant data regarding chemotherapy use in the perioperative setting for early stage NSCLC. Read More

    Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population.
    J Hum Genet 2017 Oct 5. Epub 2017 Oct 5.
    Molecular and Genetic Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
    ETS proto-oncogene 1, transcription factor (ETS1) is involved in various immune responses. Genome-wide association studies on systemic lupus erythematosus in Chinese populations identified the association of ETS1 polymorphism in 3' untranslated region, rs1128334A, which was associated with lower ETS1 expression. In view of substantial sharing of susceptibility genes across multiple autoimmune diseases, we examined whether ETS1 is associated with a rare autoimmune rheumatic disease, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Read More

    Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population.
    Environ Health Prev Med 2017 Apr 7;22(1):35. Epub 2017 Apr 7.
    Department of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
    Background: Recently, the association of plasma free amino acid (PFAA) profile and lifestyle-related diseases has been reported. However, few studies have been reported in large Asian populations, about the usefulness of PFAAs for evaluating disease risks. We examined the ability of PFAA profiles to evaluate lifestyle-related diseases in so far the largest Asian population. Read More

    L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease.
    Sci Rep 2017 Nov 21;7(1):15944. Epub 2017 Nov 21.
    Advanced Clinical Research Center, Institute for Neurological Disorders, Kawasaki, Japan.
    Lysosomal storage disorders are characterized by progressive accumulation of undigested macromolecules within the cell due to lysosomal dysfunction. 573C10 is a Schwann cell line derived from a mouse model of Niemann-Pick type C disease-1, NPC (-/-). Under serum-starved conditions, NPC (-/-) cells manifested impaired autophagy accompanied by an increase in the amount of p62 and lysosome enlargement. Read More

    The role of echocardiography in Kawasaki disease.
    Int J Rheum Dis 2017 Nov 19. Epub 2017 Nov 19.
    Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
    Kawasaki disease (KD) is an acute, self-limited vasculitis affecting young children. It can result in coronary artery abnormalities in a significant proportion of patients, especially if the diagnosis is missed or treatment gets delayed. Echocardiography is the imaging modality of choice for detection of coronary artery abnormalities and assessment of myocardial function. Read More

    History of the worldwide emergence of Kawasaki disease.
    Int J Rheum Dis 2017 Nov 19. Epub 2017 Nov 19.
    Department of Pediatrics, School of Medicine and Rady Children's Hospital, University of California San Diego, La Jolla, CA, USA.
    Dr. Kawasaki saw his first case of the disease that would come to bear his name in 1961. His meticulous description of the clinical syndrome persists as the case definition to the present day. Read More

    De novo acute lymphoblastic leukemia-like disease of high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a case report and literature review.
    BMC Clin Pathol 2017 9;17:21. Epub 2017 Nov 9.
    Division of Hematology & Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511 Japan.
    Background: B-cell lymphomas harboring the 8q24/MYC plus 18q21/BCL2 translocations are now referred to as high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-MBR). Although HGBL-MBR is frequently found in cases with diffuse large B-cell lymphoma or Burkitt lymphoma-like B-cell lymphoma, acute lymphoblastic leukemia (ALL)-like disease of HGBL-MBR (AL-HGBL-MBR) has been reported incidentally.

    Case Presentation: A 69-year-old Japanese woman developed remittent fever and increasing systemic bone pain. Read More

    Gastrointestinal and Hepatic Disease in Vasculitis.
    Rheum Dis Clin North Am 2018 Feb;44(1):1-14
    Denver Veterans Affairs Medical Center, University of Colorado School of Medicine, Denver, CO, USA. Electronic address:
    Vasculitis is an inflammatory condition that targets the blood vessels, which may occur in isolation or as a component of a systemic inflammatory condition. Although many of the vasculitides can directly affect the organs of the gastrointestinal system, some types exhibit a proclivity for certain gastrointestinal and hepatic organs. Often a patient presents with nonspecific symptoms, delaying the diagnosis and treatment of the underlying vasculitis. Read More

    A lower eicosapentaenoic acid/arachidonic acid ratio is associated with in-hospital fatal arrhythmic events in patients with acute myocardial infarction: a J-MINUET substudy.
    Heart Vessels 2017 Nov 16. Epub 2017 Nov 16.
    Division of Coronary Artery Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501, Japan.
    The ratio of serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) is significantly associated with long-term clinical outcomes in patients with acute myocardial infarction (AMI). However, it has not been conclusively demonstrated that higher serum EPA/AA ratio fares better clinical outcomes in the early phase of AMI. The Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) is a prospective multicenter registry conducted in 28 Japanese medical institutions between July 2012 and March 2014. Read More

    Relapse of nephrotic syndrome triggered by Kawasaki disease.
    CEN Case Rep 2017 Nov 15. Epub 2017 Nov 15.
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
    Minor infections, allergies, insect bites, and bee stings are commonly reported causes of nephrotic syndrome (NS). Herein, we report, to the best of our knowledge, the first case of NS relapse due to Kawasaki disease (KD). An 8-year-old boy presented with high fever of 4-day duration. Read More

    Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans.
    Chron Respir Dis 2017 Jan 1:1479972317741896. Epub 2017 Jan 1.
    1 Department of Radiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa Prefecture, Japan.
    The objective of this study was to investigate the relationship between the extent of emphysema and heart size in patients with chronic obstructive pulmonary disease (COPD) using inspiratory and expiratory chest computed tomography (CT). This retrospective study was approved by the institutional review board and informed consent was waived. We measured lung volume (LV), low attenuation area percent (%LAA; less than or equal to -950 HU), maximum cardiac area, and maximum transverse cardiac diameter on inspiratory/expiratory chest CT in 60 patients with COPD. Read More

    Increased Kawasaki Disease Incidence Associated with Higher Precipitation and Lower Temperatures, Japan, 1991-2004.
    Pediatr Infect Dis J 2017 Nov 14. Epub 2017 Nov 14.
    1. Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 2. Jichi Medical University, Shimotsuke, Tochigi, Japan.
    Background: Kawasaki disease (KD) is an acute febrile vasculitis which primarily affects children. The etiology of KD is unknown: while certain characteristics of the disease suggest an infectious origin, genetic or environmental factors may also be important. Seasonal patterns of KD incidence are well-documented, but it is unclear whether these patterns are caused by changes in climate or by other unknown seasonal effects. Read More

    [A Case of Advanced Gastric Cancer Responding to Neoadjuvant Chemotherapy with Docetaxel, Cisplatin, and 5-Fluorouracil, Leading to a Pathological Complete Response].
    Gan To Kagaku Ryoho 2017 Nov;44(11):1017-1020
    Dept. of Surgery, Matsudo City Hospital.
    We report a 72-year-old woman who was initially diagnosed with locally advanced gastric cancer with involvement of the esophagus and pancreas. She received 3 courses of neoadjuvant chemotherapy(NAC)with docetaxel, cisplatin, and 5- fluorouracil(the DCF regimen)and achieved an excellent response. She underwent total gastrectomy with distal pancreatectomy, splenectomy, and D2 lymphadenectomy. Read More

    Efficacy of Rebamipide Instillation for Contact Lens Discomfort With Dry Eye.
    Eye Contact Lens 2017 Nov 10. Epub 2017 Nov 10.
    Department of Ophthalmology (T.I., M.K., C.Y., C.F., H.T.), Nippon Medical School, Tokyo, Japan; and Department of Ophthalmology (H.S.), Nippon Medical School Musashikosugi Hospital, Kawasaki City, Japan.
    Objective: To examine the effects of rebamipide ophthalmic solution on the symptoms, signs, and cytokine concentrations in tear fluid among soft contact lens (SCL) wearers with Dry eye disease (DED).

    Methods: From November 2015 to June 2017, this open-label, single-arm study examined 40 eyes of 20 SCL wearers with DED who had been using daily disposable SCLs for >3 months (mean age, 30.0±8. Read More

    Magnetic Resonance Imaging of a Urethral Caruncle and the Pathologic Correlation: A Report of 3 Cases.
    J Comput Assist Tomogr 2017 Nov/Dec;41(6):962-964
    From the *Department of Radiology, St. Marianna University School of Medicine, Kawasaki; †Department of Radiology, Showa University Fujigaoka Hospital, Tokyo; and ‡Department of Urology, Showa University Fujigaoka Hospital; and §Department of Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan.
    A urethral caruncle is the most common disease of the urethra in postmenopausal women. A definitive diagnosis can usually be reached based on physical examination. Cross-sectional imaging is performed when malignant urethral tumor is suspected, such as a urethral carcinoma. Read More

    Diagnosis of Kawasaki disease.
    Int J Rheum Dis 2017 Nov 13. Epub 2017 Nov 13.
    Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post-Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
    Kawasaki disease (KD) is a medium vessel vasculitis with predilection for coronary arteries. Due to lack of a reliable confirmatory laboratory test, the diagnosis of KD is based on a constellation of clinical findings that appear in a typical temporal sequence. These diagnostic criteria have been modified from time to time and the most recent guidelines have been proposed by the American Heart Association (AHA) in 2017. Read More

    Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation.
    Stem Cell Reports 2017 Nov 3. Epub 2017 Nov 3.
    Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:
    Several groups have reported the existence of a form of pluripotency that resembles that of mouse embryonic stem cells (mESCs), i.e., a naive state, in human pluripotent stem cells; however, the characteristics vary between reports. Read More

    Nuclear inverse polarity papillary lesions lacking myoepithelial cells: A report of two cases.
    Pathol Int 2017 Nov 10. Epub 2017 Nov 10.
    Department of Pathology, St. Marianna University School of Medicine, Kawasaki city, Kanagawa prefecture, Japan.
    Here, cases of a 68- (Case 1) and a 44-year-old (Case 2) female are presented. They had an abnormality in the breast, and came to our hospital for further examination and treatment. Radiologically, malignancy could not completely excluded so breast excision was performed. Read More

    Monitoring the South African population's salt intake: spot urine v. 24 h urine.
    Public Health Nutr 2017 Nov 10:1-9. Epub 2017 Nov 10.
    1Centre of Excellence for Nutrition (CEN),North-West University,Private Bag X6001,Potchefstroom 2520,South Africa.
    Objective: The present study set out to determine whether morning spot urine samples can be used to monitor Na (and K) intake levels in South Africa, instead of the 'gold standard' 24 h urine sample.

    Design: Participants collected one 24 h and one spot urine sample for Na and K analysis, after which estimations using three different formulas (Kawasaki, Tanaka and INTERSALT) were calculated.

    Setting: Between 2013 and 2015, urine samples were collected from different population groups in South Africa. Read More

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