30,675 results match your criteria Kawasaki Disease
Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.
Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Japan.
Background: The purpose of this study was to reveal the mid- and long-term mortality rates among patients with thoracoabdominal aortic aneurysm (TAAA) following open TAAA repair (TAAAR) and to clarify the impact of aneurysm type on mortality.
Methods: We retrospectively analyzed data for 393 patients (290 males; age, 63.2 ± 12. Read More
J Biol Chem 2018 Dec 14. Epub 2018 Dec 14.
Osaka University Graduate School of Medicine, Japan.
The corneal endothelium, which originates from the neural crest via the periocular mesenchyme (PM), is crucial for maintaining corneal transparency. The development of corneal endothelial cells (CECs) from the neural crest is accompanied by the expression of several transcription factors, but the contribution of some of these transcriptional regulators to CEC development is incompletely understood. Here, we focused on activating enhancer-binding protein 2 (TFAP2, AP-2), a neural crest-expressed transcription factor. Read More
Diabetes 2018 Dec 14. Epub 2018 Dec 14.
Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka, Japan
The first genome-wide association study of fulminant type 1 diabetes mellitus was performed in Japanese individuals. As previously reported using a candidate gene approach, a strong association was observed with multiple SNPs in the HLA region, and the strongest association was observed with rs9268853 in the class II DR region (P=1.56 x 10, odds ratio [OR] 3. Read More
Respir Investig 2018 Dec 11. Epub 2018 Dec 11.
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Electronic address:
Background: Cigarette smoking in patients with asthma leads to poor symptom control. As patients who are current smokers have been excluded from enrollment in many clinical trials on asthma, there are few reports on the treatment in current smokers with asthma. In this study, we aimed to assess how respiratory physicians manage asthma in current smokers in Japan. Read More
An Pediatr (Barc) 2018 Dec 11. Epub 2018 Dec 11.
Servicio de Pediatría, Hospital Universitario de Cabueñes, Gijón, Asturias, España.
J Rural Health 2018 Dec 14. Epub 2018 Dec 14.
Department of Family and Community Medicine, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Shizuoka, Japan.
Purpose: In rural areas, the management of hospitalizations and emergency department (ED) visits is an important issue, and it is compounded by factors such as the long distance to secondary care facilities, funding difficulties in many rural medical institutions, and shortage of medical staff. While better patient experience (PX) has been shown to reduce hospitalizations and ED visits, previous studies have not considered the differences between urban and rural areas. In addressing this gap, this study examines the association between PX and hospitalizations/ED visits on isolated islands. Read More
Pediatr Infect Dis J 2018 Dec 13. Epub 2018 Dec 13.
Department of Pediatrics, Sendai Medical Center, 2-8-8 Miyagino, Sendai 983-8520, Japan.
Background: Kawasaki disease (KD) is an acute, systemic vasculitis syndrome that occurs in children. The clinical symptoms and epidemiological features of KD strongly suggest that KD is triggered by unidentified infectious agents in genetically predisposed patients. In addition, a number of studies have described the role of B cells in the development of KD. Read More
Eur J Immunol 2018 Dec 13. Epub 2018 Dec 13.
School of Biosciences, University of Birmingham, United Kingdom.
Pediatr Int 2018 Dec 11. Epub 2018 Dec 11.
University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Acta Otorrinolaringol Esp 2018 Dec 10. Epub 2018 Dec 10.
Department of Otolaryngology, Toranomon Hospital, Tokyo Japan.
BMC Pediatr 2018 Dec 12;18(1):386. Epub 2018 Dec 12.
Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi, Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan.
Background: The clinical features and laboratory parameters of patients with Kawasaki disease (KD) and systemic juvenile idiopathic arthritis (sJIA) occasionally overlap. Therefore, serum levels of cytokine and ferritin are used as markers to distinguish between KD and sJIA. KD patients have a high level of interleukin (IL)-6, low level of IL-18, and no elevation of the level of serum ferritin. Read More
Regen Ther 2019 Jun 20;10:27-35. Epub 2018 Nov 20.
Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Introduction: Understanding how extracellular matrix (ECM) protein composition regulates the process of human induced pluripotent stem cell (hiPSC) colony formation may facilitate the design of optimal cell culture environments. In this study, we investigated the effect of migratory behaviors on hiPSC colony formation on various ECM-coated surfaces.
Methods: To quantify how different ECM proteins affect migratory behavior during the colony formation process, single cells were seeded onto surfaces coated with varying concentrations of different ECM proteins. Read More
J Diabetes Res 2018 7;2018:9435401. Epub 2018 Nov 7.
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
It is very important to explore how we can reduce urinary albumin excretion which is an independent risk factor for ischemic heart disease. In this study, we retrospectively evaluated the effects of RAS inhibitor therapy on diabetic nephropathy in Japanese subjects whose urinary albumin levels were within normal range. We enrolled 100 subjects with type 2 diabetes who did not take any renin-angiotensin system (RAS) inhibitor. Read More
Clin Rheumatol 2018 Dec 6. Epub 2018 Dec 6.
Department of Cardiology, Children's Hospital, Zhejiang University School of Medicine, No. 3333, Binsheng Road, Hangzhou, 310052, People's Republic of China.
Objectives: To clarify the independent risk factors and construct a scoring system for Kawasaki disease (KD) with coronary artery lesions (CAL) at acute and subacute stages.
Method: Data of KD inpatients at acute and subacute stages were reviewed in a tertiary care center from January 2009 to December 2014.
Results: A total of 2305 acute and subacute KD cases were enrolled in this study with a CAL rate of 24. Read More
Ann Surg Oncol 2018 Dec 6. Epub 2018 Dec 6.
Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, Kagoshima, Japan.
Background: A metabolic shift to glycolysis is reportedly involved in radioresistance. We examined whether pretreatment F-fluorodeoxyglucose positron emission tomography (FDG-PET), which can detect enhanced glucose uptake, was able to predict the therapeutic response to chemoradiotherapy (CRT) in patients with pancreatic cancer (PC).
Methods: Of 125 PC patients (75 unresectable and 50 borderline resectable), 37 and 26 underwent induction chemotherapy before CRT and surgical resection after CRT, respectively. Read More
Haematologica 2018 Dec 6. Epub 2018 Dec 6.
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Second allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for patients with hematologic malignancies. However, it is unclear whether HLA discrepancy between graft and first donor has an impact on the outcome of second HSCT. We retrospectively analyzed 646 patients receiving second HSCT after an initial HLA mismatched (MM) transplantation. Read More
Haematologica 2018 Dec 6. Epub 2018 Dec 6.
Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Double-hit and double-protein-expression lymphoma with and rearrangements is a rare mature B-cell neoplasm characterized by germinal center B-cell phenotype, abundant protein expression of MYC and BCL2, rapid disease progression, and a poor prognosis. In this study, we showed the potential benefit of BCL2 inhibitor venetoclax against this disease. Immunohistochemistry on the lymphoma tissues confirmed that overexpression of MYC and BCL2 was observed more frequently in this subtype than in other germinal center B-cell-like diffuse large B-cell lymphomas. Read More
Trials 2018 Dec 6;19(1):673. Epub 2018 Dec 6.
KHANA Center for Population Health Research, Phnom Penh, Cambodia.
Background: Currently, the number of children living with HIV is the highest ever. This has led to an increased focus on a healthy life expectancy in this population. Improving oral health status may contribute to improved immunity, which could in turn lead to greater overall health in this population. Read More
Cereb Cortex 2018 Dec 12. Epub 2018 Dec 12.
Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
Changes in the cerebral cortex of mammals during evolution have been of great interest. Ferrets, monkeys, and humans have more developed cerebral cortices compared with mice. Although the features of progenitors in the developing cortices of these animals have been intensively investigated, those of the fiber layers are still largely elusive. Read More
Methods Mol Biol 2019 ;1904:423-429
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
Fc gamma receptors (FcγRs) are expressed on the surface of various immune cells, and the interactions between FcγRs and the Fc region of immunoglobulin G are involved in the activation of immune cells by antigen-bound antibodies. Fc-mediated immune-cell activations are related to both the efficacy and the safety of therapeutic monoclonal antibodies. It is indispensable to elucidate the Fc-mediated functions in the development of therapeutic monoclonal antibodies. Read More
Sci Adv 2018 Dec 7;4(12):eaat9989. Epub 2018 Dec 7.
RIKEN Center for Emergent Matter Science (CEMS), Wako 351-0198, Japan.
Multiferroic materials with both ferroelectric and ferromagnetic orders provide a promising arena for the electrical manipulation of magnetization through the mutual correlation between those ferroic orders. Such a concept of multiferroics may expand to semiconductor with both broken symmetries of spatial inversion and time reversal, that is, polar ferromagnetic semiconductors. Here, we report the observation of current-driven magnetization switching in one such example, (Ge,Mn)Te thin films. Read More
J Ophthalmol 2018 12;2018:2353428. Epub 2018 Nov 12.
Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0114, Japan.
Purpose: To evaluate the effect of smoking on the outcome of antivascular endothelial growth factor (VEGF) therapy in patients with neovascular age-related macular degeneration (nAMD).
Methods: This retrospective case-control study included 64 eyes in 59 patients with treatment-naïve nAMD. Smoking habits were obtained from hospital records and patient recall. Read More
Clin Ophthalmol 2018 26;12:2409-2414. Epub 2018 Nov 26.
Department of Ophthalmology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan,
Purpose: The purpose of this study was to compare straight and angled incisions in 27-gauge microincision vitrectomy in patients with epiretinal membrane (ERM).
Methods: Seventy-three eyes of 68 patients with ERM who underwent straight (35 eyes) or angled incision (38 eyes) for 27-gauge microincision vitrectomy were retrospectively evaluated.
Results: No statistically significant difference was found between the two groups in postoperative logarithm of minimal angle of resolution best-corrected visual acuity. Read More
Am J Geriatr Psychiatry 2018 Nov 20. Epub 2018 Nov 20.
Department of Psychiatry, Kawasaki Memorial Hospital, Kawasaki, Japan. Electronic address:
Microbiol Immunol 2018 Dec 11. Epub 2018 Dec 11.
Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.
Trichodysplasia spinulosa associated polyomavirus (TSPyV), a newly identified polyomavirus has been implicated as a causative agent of trychodysplasia spinulosa (TS), a rare proliferative skin disease in severly immunocompromised hosts. The diagnosis using monoclonal antibodies (mAbs) has been provided as a promising tool as it offers high specificity towards specific antigen. Till there is no good mAb available for diagnosis of TS disease. Read More
Br J Clin Pharmacol 2018 Dec 9. Epub 2018 Dec 9.
Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, Australia.
Congenit Anom (Kyoto) 2018 Dec 10. Epub 2018 Dec 10.
Institute of Medical Genetics, Tokyo Women's Medical University, Tokyo, Japan.
Microdeletions in 1p35.2 region are rare and there are only two reports . Here, we report an additional patient with a de novo 1p35. Read More
Int J Hematol 2018 Dec 8. Epub 2018 Dec 8.
Division of Hematology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
We evaluated clinical outcomes of disseminated intravascular coagulation (DIC) in patients with hematological malignancies treated with synthetic protease inhibitors (SPIs) and compared the effects of gabexate mesilate (FOY) and nafamostat mesilate (FUT). We retrospectively examined 127 patients [acute myeloid leukemia (n = 48), acute lymphoblastic leukemia (n = 25), and non-Hodgkin lymphoma (n = 54)] with DIC, who were diagnosed according to Japanese Ministry of Health, Labour and Welfare criteria and treated with SPIs [FOY (n = 55) and FUT (n = 72)] at our hospital from 2006 to 2015. The DIC resolution rates on days 7 and 14 were 42. Read More
Ann Intensive Care 2018 Dec 10;8(1):123. Epub 2018 Dec 10.
Department of Emergency Medicine and Critical Care Medicine, St. Marianna University, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 2168511, Japan.
Background: Proportional modes (proportional assist ventilation, PAV, and neurally adjusted ventilatory assist, NAVA) could improve patient-ventilator interaction and consequently may be efficient as a weaning mode. The purpose of this systematic review is to examine whether proportional modes improved patient-ventilator interaction and whether they had an impact on the weaning success and length of mechanical ventilation, in comparison with PSV.
Methods: We searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from inception through May 13, 2018. Read More
Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.
Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Republic of Korea.
Objectives: Kawasaki disease (KD) is an acute systemic vasculitis of unknown aetiology that affects infants and young children. Recent reports of elevated serum high mobility group box 1 (HMGB1) level during the acute phase of KD and its relationship to poor response to IVIG treatment suggest a possible association of HMGB1 polymorphisms with KD. We investigated the association between the polymorphisms of the HMGB1 gene, KD susceptibility, coronary artery lesions, and KD response to IVIG treatment. Read More
Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.
Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Objectives: The European Single Hub and Access point for paediatric Rheumatology in Europe initiative aimed to optimize care for children with rheumatic diseases. Kawasaki disease (KD) is the most common cause of acquired heart disease in children and an important cause of long-term cardiac disease into adulthood. Prompt diagnosis and treatment of KD is difficult due to the heterogeneity of the disease but is crucial for improving outcome. Read More
Am J Clin Nutr 2018 Sep;108(3):532-547
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Background: 24-h urine collections are the suggested method to measure daily urinary potassium excretion (uK) but are costly and burdensome to implement.
Objective: This study tested how well existing equations with the use of spot urine samples can estimate 24-h uK and if accuracy varies by timing of spot urine collection, age, race, or sex.
Design: This cross-sectional study used data from 407 participants aged 18-39 y from the Washington, DC area in 2011 and 554 participants aged 45-79 y from Chicago in 2013. Read More
Eur J Pharmacol 2018 Dec 6. Epub 2018 Dec 6.
Institute of Medical Science, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki 216-8512, Japan.
The use of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammatory pain is limited by gastrointestinal complications. The rapid action of NSAIDs is associated with better pain relief. Previously, we demonstrated that fluoro-loxoprofen, a novel NSAID, has less ulcerogenic potential than other NSAIDs, attributable to its gastroprotective properties. Read More
Neuroimage 2018 Dec 5. Epub 2018 Dec 5.
Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, 444-8585, Japan.
View-invariant face processing emerges early in life. A previous study (Nakato et al., 2009) measured infant hemodynamic responses to faces from the frontal and profile views in the bilateral temporal areas, which have been reported to be involved in face processing using near-infrared spectroscopy. Read More
Semin Thorac Cardiovasc Surg 2018 Dec 7. Epub 2018 Dec 7.
Department of Anesthesiology, Shizuoka General Hospital.
Objective: This study was performed to investigate the association between the esophagectomy surgical Apgar score (eSAS) and 30-day morbidity after esophagectomy.
Methods: We retrospectively identified patients who underwent esophagectomy in our facilities database from January 2011 through December 2015. We calculated the eSAS and modified eSAS, which was adjusted for the blood loss volume, according to our patients' data. Read More
Cardiovasc Revasc Med 2018 Nov 17. Epub 2018 Nov 17.
Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, United States of America. Electronic address:
Takotsubo syndrome (TTS) is an acute cardiac condition independent of epicardial coronary obstruction that mimics acute coronary syndrome and is characterized by acute heart failure with reversible ventricular motion abnormalities. This consensus paper is the result of a multinational effort aiming to summarize the current state of the art on TTS. Experts in the field provide a thorough and detailed review of this syndrome. Read More
Ann Emerg Med 2018 Dec 4. Epub 2018 Dec 4.
Department of Emergency Medicine and Critical Care, Japanese Red Cross Society Kyoto Daini Hospital, Kyoto, Japan.
Instantaneous rigor is the immediate appearance of rigor mortis after cardiac arrest. To our knowledge, no previous reports exist on resuscitation of such patients. A young athlete suddenly collapsed with cardiac arrest during a marathon; his legs stiffened with instantaneous rigorlike stiffness. Read More
Best Pract Res Clin Rheumatol 2018 02 16;32(1):3-20. Epub 2018 Nov 16.
Faculty of Health and Applied Sciences, University of the West of England, University Hospitals Bristol NHS Trust, Bristol, UK. Electronic address:
Classification of the vasculitides has been traditionally based on vessel size. The American College of Rheumatology (ACR) criteria were developed in the 1980s and published in 1990 before the development of ANCA testing and modern imaging techniques such as MRI and PET scanning, and therefore, these criteria are not fit for use in 2010s. The Chapel Hill Consensus Conference provided a framework for defining various types of vasculitis. Read More
Arthritis Res Ther 2018 Dec 10;20(1):274. Epub 2018 Dec 10.
Department of Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Biosci Biotechnol Biochem 2018 Dec 10:1-9. Epub 2018 Dec 10.
a Department of Applied Biological Chemistry , Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo , Japan.
The monoterpene isolated from Mentha haplocalyx, 3,3,5-trimethyl-2-oxabicyclo[2.2.2]oct-5-en-4-ol, was synthesized according to its proposed structure. Read More
Arch Oral Biol 2018 Nov 28;98:238-242. Epub 2018 Nov 28.
Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama 701-0193, Japan. Electronic address:
Objective: The aim of the present study was to investigate whether anterior tongue muscle strengthening exercises can affect the strength of posterior tongue muscles.
Design: Eleven healthy subjects (20.6 ± 1. Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Department of Bio and Environmental Chemistry, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan. Electronic address:
This study aims to quantitatively investigate the interaction between sulfated polysaccharides with potent anti-HIV activity, dextran and curdlan sulfates with negatively charged sulfate groups, and poly-l-lysine as a model protein and oligopeptides from a HIV surface glycoprotein gp120 with positively charged amino acids using surface plasmon resonance (SPR) and dynamic light scattering (DLS) to elucidate the anti-HIV mechanism of sulfated polysaccharides. The apparent association- (k) and dissociation rate (k) constants of dextran and curdlan sulfates against poly-l-lysine were k = 6.92 × 10-2. Read More
Cardiol Young 2018 Dec 6:1-4. Epub 2018 Dec 6.
Department of Pediatrics,Shinshu University School of Medicine,Asahi 3-1-1, Matsumoto,Japan.
Giant coronary artery aneurysms are a complication of Kawasaki disease and can be fatal if associated with thrombosis. We describe the clinical outcome of a boy with Kawasaki disease who exhibited "supergiant" coronary artery aneurysms at the age of 14 months and, despite treatment with anticoagulant and antiplatelet medication, developed a left coronary artery thrombosis and presented following a myocardial infarction at 2 years old. Although his symptoms were minimal, the myocardial infarction was identified by abnormal Q-waves and giant negative T-waves in precordial leads of routine electrocardiography. Read More
Cancer Sci 2018 Dec 6. Epub 2018 Dec 6.
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan, 329-0498.
Nonalcoholic steatohepatitis (NASH) is a common cause of liver cirrhosis and hepatocellular carcinoma (HCC). However, effective therapeutic strategies for preventing and treating NASH-mediated liver cirrhosis and HCC are lacking. Cholesterol is closely associated with vascular endothelial growth factor (VEGF), a key factor that promotes HCC. Read More
J Paediatr Child Health 2018 Dec 5. Epub 2018 Dec 5.
Division of Paediatric Cardiology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore.
Aim: We aimed to assess the utility of four published risk-scoring methods in predicting intravenous immunoglobulins (IVIG) non-responsiveness in Kawasaki disease (KD) patients from Singapore and develop a new predictive model.
Methods: We reviewed the medical records of 215 KD children. The performance of existing scoring methods in identifying non-responsive cases based on sensitivities (SN) and specificities (SP) was evaluated in 122 Singaporean Chinese. Read More
World J Emerg Surg 2018 29;13:56. Epub 2018 Nov 29.
Division of Trauma and Surgical Critical Care, Osaka General Medical Center, 3-1-56 Bandai-Higashi, Sumiyoshi-ku, Osaka, 558-8558 Japan.
Background: The outcomes of multiple injury patients with concomitant torso hemorrhage and traumatic brain injury (TBI) are very poor. The hybrid emergency room system (HERS) is a trauma management system designed to complete resuscitation, computed tomography (CT), surgery, angioembolization, and intracranial pressure (ICP) monitoring all in one trauma resuscitation room without patient transfer. We aimed to review the outcomes of polytrauma patients who underwent concurrent bleeding control and ICP monitoring using the HERS. Read More
Sci Rep 2018 Dec 5;8(1):17682. Epub 2018 Dec 5.
Ted Rogers Centre for Heart Research, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Ontario, Canada.
Detailed epidemiologic examination of the distribution of Kawasaki disease (KD) cases could help elucidate the etiology and pathogenesis of this puzzling condition. Location of residence at KD admission was obtained for patients diagnosed in Canada (excluding Quebec) between March 2004 and March 2015. We identified 4,839 patients, 164 of whom (3. Read More
Nihon Koshu Eisei Zasshi 2018 ;65(11):666-676
Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan.
Objectives In Japan, nationwide data of the incidence of infectious diseases have been collected via the National Epidemiological Surveillance of Infectious Diseases (NESID) since 1981. In addition, since March 2014, Kawasaki City has operated its own real-time surveillance (RTS) system to collect data of the incidence of influenza from medical institutions across the city. This study aimed to describe the characteristics of the RTS system and compare the two surveillance systems to improve measures against infectious diseases in the future. Read More
Development 2018 Dec 5;145(23). Epub 2018 Dec 5.
Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Kimiidera, Wakayama 641-8509, Japan.
Previous studies have established that fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) show distinct functional characteristics. However, the lineage relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal stage. Read More