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    9858 results match your criteria Kawasaki Disease

    1 OF 198

    Impact of restrictive lung disorder on cardiovascular mortality in a general population: The Yamagata (Takahata) study.
    Int J Cardiol 2017 Apr 20. Epub 2017 Apr 20.
    Department of Internal Medicine, National Insurance Kuzumaki Hospital, Iwate, Japan.
    Background: Obstructive lung disorder (OLD) is known to be associated with cardiovascular disease. However, the impact of restrictive lung disorder (RLD) on cardiovascular mortality has not been fully investigated in the apparently healthy general population.

    Objectives: To clarify whether RLD is associated with cardiovascular mortality in the general population. Read More

    Novel Risk Assessment Tool for Immunoglobulin-Resistance in Kawasaki Disease: Application Using a Random Forest Classifier.
    Pediatr Infect Dis J 2017 Apr 24. Epub 2017 Apr 24.
    1Department of Pediatrics, Kikkoman General Hospital, Chiba, Japan 2Department of Pediatrics, The University of Tokyo, Tokyo, Japan 3Department of Pediatrics, Yaizu City Hospital, Shizuoka, Japan 4Department of Pediatrics, Ome Municipal Hospital, Tokyo, Japan 5Department of Pediatrics, Ohta-Nishinouchi Hospital, Fukushima, Japan 6Department of Pediatrics, Chigasaki Municipal Hospital, Kanagawa, Japan 7Department of Pediatrics, Saitama Citizens Medical Center, Saitama, Japan 8Department of Pediatrics, Fujieda Municipal General Hospital, Shizuoka, Japan.
    Background: Resistance to intravenous immunoglobulin (IVIG) therapy is a risk factor for coronary lesions in patients with Kawasaki disease (KD). Risk-adjusted initial therapy may improve coronary outcome in KD, but identification of high risk patients remains a challenge. This study aimed to develop a new risk assessment tool for IVIG-resistance using advanced statistical techniques. Read More

    Development of a Japanese encephalitis virus-like particle vaccine in silkworms using codon-optimised prM and envelope genes.
    Heliyon 2017 Apr 11;3(4):e00286. Epub 2017 Apr 11.
    The Institute of Biological Resources, 893-2, Nakayama, Nago-shi, Okinawa 905-0004, Japan.
    We have successfully prepared a Japanese encephalitis virus (JEV) - Nakayama virus like particle (NVLP) vaccine using synthetic codon-optimized prM and E genes. The expression of the recombinant JEV Nakayama-BmNPV (JEV-NNPV) virus was determined in infected silkworm Bm-N cells by fluorescence and Western blot analysis. The recombinant was inoculated into silkworm pupae and the yield of Nakayama VLP (NVLP) reached a peak in the homogenates after 3 days. Read More

    Observational study of Interleukin-21 (IL-21) does not distinguish Kawasaki disease from other causes of fever in children.
    Pediatr Rheumatol Online J 2017 Apr 20;15(1):32. Epub 2017 Apr 20.
    Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
    Background: Kawasaki disease (KD) is a febrile childhood vasculitis of unknown etiology. The diagnosis is highly concerning as over a quarter of children who fail to receive timely treatment with intravenous immunoglobulin (IVIG) will develop coronary aneurysms. Diagnosis relies on proper symptomatology and is supported by non-specific markers of inflammation. Read More

    Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report.
    BMC Pediatr 2017 Apr 20;17(1):108. Epub 2017 Apr 20.
    Department of Pediatrics, Division of Allergy, Immunology, Rheumatology and Kawasaki Disease, University of California San Diego and Rady Children's Hospital, 9500 Gilman Drive #0760, La Jolla, San Diego, CA, 92093, USA.
    Background: Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) is the second most common heritable autoinflammatory disease, typically presenting in pre-school aged children with fever episodes lasting 1-3 weeks. Systemic symptoms can include rash, myalgia, ocular inflammation, and serositis.

    Case Presentation: Here we report an unusual presentation of TRAPS in a 7 month old girl who presented with only persistent fever. Read More

    Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene.
    PLoS Genet 2017 Apr 20;13(4):e1006696. Epub 2017 Apr 20.
    Glycometabolome Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center, Global Research Cluster, RIKEN, Saitama, Japan.
    The cytoplasmic peptide:N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme that is highly conserved among eukaryotes. It was recently reported that subjects harboring mutations in the NGLY1 gene exhibited severe systemic symptoms (NGLY1-deficiency). While the enzyme obviously has a critical role in mammals, its precise function remains unclear. Read More

    Serum monomeric laminin-γ2 as a novel biomarker for hepatocellular carcinoma.
    Cancer Sci 2017 Apr 18. Epub 2017 Apr 18.
    Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
    The diagnosis of hepatocellular carcinoma (HCC) in the early stages is important for successful clinical management. Laminin (Ln)-γ2 expression has been reported in various types of malignant carcinomas. We recently developed a highly sensitive method to measure serum monomeric Ln-γ2 levels using a fully automated chemiluminescent immunoassay (CLIA). Read More

    Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker.
    Int J Mol Sci 2017 Apr 12;18(4). Epub 2017 Apr 12.
    Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
    Kawasaki disease (KD) is an autoimmune-like disease and acute childhood vasculitis syndrome that affects various systems but has unknown etiology. In addition to the standard diagnostic criteria, anemia is among the most common clinical features of KD patients and is thought to have a more prolonged duration of active inflammation. In 2001, the discovery of a liver-derived peptide hormone known as hepcidin began revolutionizing our understanding of anemia's relation to a number of inflammatory diseases, including KD. Read More

    Kawasaki Disease and Labyrinthitis: An Underdiagnosed Complication.
    J Audiol Otol 2017 Apr 30;21(1):53-56. Epub 2017 Mar 30.
    Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Sensorineural hearing loss (SNHL) that is seldom cited as a Kawasaki disease (KD) complication is known as an additional, potentially severe, and frequently irreversible sequel. Furthermore the vestibular functions of KD have been underestimated and it could be an important complication combined with SNHL in KD. We described a case that a 4 year-old boy who developed vestibular loss with SNHL has recovered successfully with a combined treatment. Read More

    Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.
    PLoS One 2017 17;12(4):e0175649. Epub 2017 Apr 17.
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Background: The genetic architecture of coronary artery disease has not been fully elucidated, especially in Asian countries. Moyamoya disease is a progressive cerebrovascular disease that is reported to be complicated by coronary artery disease. Because most Japanese patients with moyamoya disease carry the p. Read More

    Molecular evolution of the fusion protein (F) gene in human respiratory syncytial virus subgroup B.
    Infect Genet Evol 2017 Apr 14;52:1-9. Epub 2017 Apr 14.
    Department of Microbiology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanagawa-ku, Yokohama-shi, Kanagawa 236-0004, Japan.
    In this study, we examined the molecular evolution of the fusion protein (F) gene in human respiratory syncytial virus subgroup B (HRSV-B). First, we performed time-scale evolution analyses using the Bayesian Markov chain Monte Carlo (MCMC) method. Next, we performed genetic distance, linear B-cell epitope prediction, N-glycosylation, positive/negative selection site, and Bayesian skyline plot analyses. Read More

    Prognostic value of the soluble interleukin-2 receptor level after patients with follicular lymphoma achieve a response to R-CHOP.
    Hematology 2017 Apr 17:1-6. Epub 2017 Apr 17.
    a Division of Hematology, Department of Medicine , Jichi Medical University , Tochigi , Japan.
    Objectives: Follicular lymphoma (FL) is a clinically and biologically heterogeneous disease. Therefore, it is important to identify factors that can predict its clinical outcome.

    Methods: We retrospectively evaluated the usefulness of soluble interleukin-2 receptor (sIL-2R) levels after R-CHOP (posttreatment sIL-2R) in 72 patients with newly diagnosed FL who had either a complete response (CR) or partial response. Read More

    Paediatric-onset coronary artery anomalies in pregnancy: a single-centre experience and systematic literature review.
    Cardiol Young 2017 Apr 17:1-9. Epub 2017 Apr 17.
    1Toronto Congenital Cardiac Centre for Adults,Toronto General Hospital,University of Toronto,Toronto,Ontario,Canada.
    Objectives: Individuals with childhood-onset coronary artery anomalies are at increased risk of lifelong complications. Although pregnancy is thought to confer additional risk, a few data are available regarding outcomes in this group of women. We sought to define outcomes of pregnancy in this unique population. Read More

    Perivascular Accumulation of β-Sheet-Rich Proteins in Offspring Brain following Maternal Exposure to Carbon Black Nanoparticles.
    Front Cell Neurosci 2017 31;11:92. Epub 2017 Mar 31.
    The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Organization for Research Advancement, Tokyo University of ScienceNoda, Japan.
    Environmental stimulation during brain development is an important risk factor for the development of neurodegenerative disease. Clinical evidence indicates that prenatal exposure to particulate air pollutants leads to diffuse damage to the neurovascular unit in the developing brain and accelerates neurodegeneration. Maternal exposure to carbon black nanoparticles (CB-NPs), used as a model for particulate air pollution, induces long-lasting diffuse perivascular abnormalities. Read More

    High Risk of Coronary Artery Aneurysms in Infants Younger than 6 Months of Age with Kawasaki Disease.
    J Pediatr 2017 Apr 10. Epub 2017 Apr 10.
    Department of Pediatrics, University of California, San Diego, California/Rady Children's Hospital San Diego, La Jolla, San Diego, CA. Electronic address:
    Objectives: To characterize the clinical presentation and outcome in infants <6 months of age with Kawasaki disease (KD) and to describe the use of newer anti-inflammatory therapies in this young population.

    Study Design: We evaluated 88 infants <6 months old and 632 ≥6 months old treated for KD. We compared differences in laboratory data, response to treatment, and coronary artery outcomes between the 2 cohorts. Read More

    [Values of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in predicting sensitivity to intravenous immunoglobulin in Kawasaki disease].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Apr;19(4):410-413
    Department of Pediatrics, First People's Hospital of Lianyungang, Xuzhou Medical University, Lianyungang, Jiangsu 222002, China.
    Objective: To study the values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting the sensitivity to intravenous immunoglobulin (IVIG) in Kawasaki disease (KD).

    Methods: A retrospective cohort study was conducted in 404 children with newly diagnosed KD. The data on routine blood tests, NLR, and PLR were collected before and after IVIG treatment. Read More

    Adenosine A1 receptors measured with (11) C-MPDX PET in early Parkinson's disease.
    Synapse 2017 Apr 13. Epub 2017 Apr 13.
    Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo, 173-0015, Japan.
    Adenosine A1 receptors (A1 Rs) interact negatively with dopamine D1 receptors (D1 Rs) in neurons of the basal ganglia's direct pathway, while adenosine A2A receptors (A2A Rs) negatively interact with dopamine D2 receptors (D2 Rs) in indirect-pathway neurons. The aim of this study was to investigate the cerebral density of A1 Rs in Parkinson's disease (PD) in its early stages, using PET scans with the radioligand 8-dicyclopropylmethyl-1-(11) C-methyl-3-propylxanthine ((11) C-MPDX). We studied 10 drug-naïve patients with early PD. Read More

    A case of atypical Kawasaki disease with giant coronary artery aneurysm containing thrombus.
    Images Paediatr Cardiol 2016 Jul-Sep;18(3):9-15
    Department of Paediatrics, Mater Dei Hospital , Malta.
    Introduction: Kawasaki disease (KD) is an acute febrile, systemic vasculitic syndrome of unknown etiology, occurring primarily in children younger than 5 years of age. Administration of IVIG within the first 10 days after onset of fever in combination with high dose aspirin reduces the risk of coronary artery damage in KD. Though rare, giant aneurysms of the coronary arteries may develop in untreated cases and prove extremely challenging to manage. Read More

    Hypocellular acute myeloid leukemia treated with bone marrow transplantation.
    Pediatr Int 2017 Apr;59(4):490-493
    Department of Pediatrics, St Marianna University School of Medicine Hospital, Kawasaki, Japan.
    Hypocellular acute myeloid leukemia (AML) mainly occurs in elderly patients, and is extremely rare in childhood. There is still no established treatment for hypocellular AML. We report the case of an 11-year-old boy with hypocellular AML who was treated successfully with allogenic bone marrow transplantation (allo-BMT). Read More

    IL-1 Inhibition May Have an Important Role in Treating Refractory Kawasaki Disease.
    Front Pharmacol 2017 28;8:163. Epub 2017 Mar 28.
    Department of Pediatric Rheumatology, Reference Centre for Autoinflammatory Diseases, Le Kremlin-Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Sud University Hospital Paris, France.
    Kawasaki disease (KD) is an acute inflammatory vasculitis occurring in young children before 5 years and representing at this age, the main cause of acquired heart disease. A single infusion of 2 g/kg of intravenous immunoglobulins along with aspirin has reduced the frequency of coronary artery aneurysms from 25 to 5%. However, 10-20% of patients do not respond to standard treatment and have an increased risk of cardiac complications and death. Read More

    Pre-end-stage renal disease visit-to-visit systolic blood pressure variability and post-end-stage renal disease mortality in incident dialysis patients.
    J Hypertens 2017 Apr 10. Epub 2017 Apr 10.
    aDivision of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA bNephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa cDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan dDepartment of Transplantation and Surgery, Semmelweis University, Budapest, Hungary eDivision of Biostatistics, Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee fDivision of Nephrology and Hypertension, Harold Simmons Center for Chronic Disease Research and Epidemiology, University of California-Irvine, Orange, California gNephrology Section, Memphis VA Medical Center, Memphis, Tennessee, USA.
    Objectives: Higher SBP visit-to-visit variability (SBPV) has been associated with increased risk of adverse events in patients with chronic kidney disease, but the association of SBPV in advanced nondialysis-dependent chronic kidney disease with mortality after the transition to end-stage renal disease (ESRD) remains unknown.

    Methods: Among 17 729 US veterans transitioning to dialysis between October 2007 and September 2011, we assessed SBPV calculated from the SD of at least three intraindividual outpatient SBP values during the last year prior to dialysis transition (prelude period). Outcomes included factors associated with higher prelude SBPV and post-transition all-cause, cardiovascular, and infection-related mortality, assessed using multivariable linear regression and Cox and competing risk regressions, respectively, adjusted for demographics, comorbidities, medications, cardiovascular medication adherence, SBP, BMI, estimated glomerular filtration rate, and type of vascular access. Read More

    A child with resistant Kawasaki disease successfully treated with anakinra: a case report.
    BMC Pediatr 2017 Apr 8;17(1):102. Epub 2017 Apr 8.
    Pediatric Rheumatology Unit, Pediatrics Department, Hospital Sant Joan de Déu Esplugues, Barcelona, Spain.
    Background: Kawasaki disease (KD) is an acute self-limited systemic vasculitis of unknown etiology. Intravenous immunoglobulin (IVIG) is an effective treatment and decreases the risk of cardiac complications to less than 5%. In spite of its effectiveness, some children do not respond to this therapy and still develop coronary aneurysms (CAA). Read More

    Treating Helicobacter pylori effectively while minimizing misuse of antibiotics.
    Cleve Clin J Med 2017 Apr;84(4):310-318
    Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
    Experts now recommend that all Helicobacter pylori infections be eradicated unless there are compelling reasons not to. As with other infectious diseases, effective therapy should be based on susceptibility. Read More

    Comparing epidemiologic features of Kawasaki disease in winter and summer.
    Pediatr Int 2017 Apr 7. Epub 2017 Apr 7.
    Department of Public Health, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
    Background: Epidemiology of Kawasaki disease (KD) shows seasonal variations, although the etiology of KD is unknown. In this study, we compared the clinical epidemiology of KD with onset of disease in winter and summer to identify its etiology, e.g. Read More

    Using the Electronic Medical Record to Correlate Kawasaki Disease Phenotypes With Clinical Outcomes.
    J Pediatric Infect Dis Soc 2017 Apr 5. Epub 2017 Apr 5.
    Cardiology, and.
    Background.: We sought to systematically standardize the documentation of clinical and laboratory features in Kawasaki disease (KD) on the day of initial treatment and correlate the presentation with clinical outcomes.

    Methods. Read More

    Multicenter, Single-Arm, Phase IV Study of Combined Aspirin and High-Dose "IVIG-SN" Therapy for Pediatric Patients with Kawasaki Disease.
    Korean Circ J 2017 Mar 10;47(2):209-214. Epub 2017 Mar 10.
    Division of Cardiology, Department of Pediatrics, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background And Objectives: Intravenous immunoglobulin-SN (IVIG-SN) is a new human immunoglobulin product. Its safety is ensured by pathogen-elimination steps comprising solvent/detergent treatment and a nanofiltration process. This multicenter clinical study was designed to evaluate the efficacy and safety of combined aspirin and high-dose IVIG-SN therapy in pediatric patients with Kawasaki disease (KD). Read More

    Presentation of missed childhood Kawasaki disease in adults: Experience from a tertiary care center in north India.
    Int J Rheum Dis 2017 Apr 5. Epub 2017 Apr 5.
    Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Aim: Kawasaki disease (KD) is the most common cause of acquired heart disease in children in Japan, North America and Europe. Undiagnosed and untreated KD can have clinically significant consequences later in life. The clinical spectrum of missed childhood KD is frequently being recognized during adulthood. Read More

    Total knee arthroplasty for treatment of osteoarthritis with prolonged patellar dislocation.
    Arthroplast Today 2017 Mar 4;3(1):25-28. Epub 2016 Nov 4.
    Department of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
    Prolonged dislocation of the patella is a rare condition and is often related to severe osteoarthritis (OA) of the femorotibial (FT) joint. For this condition's treatment, numerous surgical techniques using total knee arthroplasty (TKA) have been published. To the best of our knowledge, this case report is the first description of the use of lateral release alone to treat recurrent patellar subluxation with TKA. Read More

    Evaluation of myocardial deformation in patients with Kawasaki disease using speckle-tracking echocardiography during mid-term follow-up.
    Cardiol Young 2017 Apr 5:1-9. Epub 2017 Apr 5.
    Pediatric Cardiology,Dr. Siyami Ersek Chest, Heart and Vessel Surgery Teaching and Research Hospital,Siyami Ersek Hospital,Istanbul,Turkey.
    Speckle-tracking echocardiography is a recently developed technique for the evaluation of myocardial deformation or strain. Our objective was to examine strain through a mid-term follow-up of patients with Kawasaki disease.

    Methods: We explored left ventricular mechanics using speckle-tracking echocardiography in 35 patients with a history of Kawasaki disease at least 6 months after the acute phase. Read More

    A child with X-linked agammaglobulinemia and Kawasaki disease: an unusual association.
    Rheumatol Int 2017 Apr 1. Epub 2017 Apr 1.
    Allergy-Immunology Unit, Advanced Pediatrics Center, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
    An association of X-linked agammaglobulinemia (XLA) with Kawasaki disease (KD) is very uncommon. Only two case reports are available so far in pediatric literature. Patients with XLA have recurrent infections and physical examination have absent lymph nodes and tonsils. Read More

    Increased aortic intima-media thickness following Kawasaki disease.
    Atherosclerosis 2017 May 19;260:75-80. Epub 2017 Mar 19.
    Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Paediatrics, University of Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Victoria, Australia. Electronic address:
    Background And Aims: The cardiovascular risk following Kawasaki disease (KD), especially in those without coronary artery changes or with regressed coronary artery lesions, is unclear. We assessed markers of early atherosclerosis in individuals following KD, including those with and without coronary artery abnormalities.

    Methods: We performed a cross-sectional case-control study of 60 patients (25 with always normal coronary arteries and 35 with abnormalities) and 60 controls, at least two years after KD. Read More

    Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide.
    Nutrition 2017 May 6;37:74-78. Epub 2016 Aug 6.
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    High sodium, high glucose, and obesity are important risk factors for age-related diseases such as cardiovascular disease (CVDs), stroke, and cancer. Coupling factor 6 (CF6) is released from vascular endothelial cells and functions as a circulating peptide that inhibits prostacyclin and nitric oxide generation by intracellular acidosis. High glucose elevates CF6 by activation of protein kinase C and p38 mitogen-activated protein kinase, whereas CF6 causes type 2 diabetes mellitus, resulting in a high glucose vicious cycle. Read More

    Clinical features and predictors of patients with critical limb ischemia who responded to autologous mononuclear cell transplantation for therapeutic angiogenesis.
    Heart Vessels 2017 Mar 29. Epub 2017 Mar 29.
    Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
    The clinical features of patients with critical limb ischemia (CLI) who responded to angiogenesis using autologous peripheral blood mononuclear cell transplantation (PB-MNC) have not yet been fully characterized, and there are no useful predictors to judge the curative effect in the early period after PB-MNC. This study sought to clarify the clinical features and predictors in patients with CLI who were successfully treated using PB-MNC. 30 consecutive patients [arteriosclerosis obliterans: 24 patients, thromboangiitis obliterans: 6 patients] who were diagnosed with major amputation despite maximal medical therapy were enrolled in this study. Read More

    Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association.
    Circulation 2017 Apr 29;135(17):e927-e999. Epub 2017 Mar 29.
    Background: Kawasaki disease is an acute vasculitis of childhood that leads to coronary artery aneurysms in ≈25% of untreated cases. It has been reported worldwide and is the leading cause of acquired heart disease in children in developed countries.

    Methods And Results: To revise the previous American Heart Association guidelines, a multidisciplinary writing group of experts was convened to review and appraise available evidence and practice-based opinion, as well as to provide updated recommendations for diagnosis, treatment of the acute illness, and long-term management. Read More

    Validation of spot urine in predicting 24-h sodium excretion at the individual level.
    Am J Clin Nutr 2017 Mar 29. Epub 2017 Mar 29.
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
    Background: Evidence for the effect of dietary sodium intake on the risk of cardiovascular disease has been controversial. One of the main explanations for the conflicting results lies in the great variability associated with measurement methods for sodium intake. Spot urine collection is a convenient method commonly used for sodium estimation, but its validity for predicting 24-h urinary sodium excretion at the individual level has not been well evaluated among the general population. Read More

    Comprehensive pathogen detection associated with four recurrent episodes of Kawasaki disease in a patient during a single year using next-generation sequencing.
    JMM Case Rep 2016 Feb 1;3(1):e005019. Epub 2016 Feb 1.
    Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases , 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640 , Japan.
    Introduction: Kawasaki disease (KD) is the most common multisystem vasculitis in childhood. Pathogens can be associated with the onset of KD. However, a lack of consistency prevails among reports about this disease. Read More

    Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease.
    Int J Pediatr 2017 28;2017:4162597. Epub 2017 Feb 28.
    Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
    Abnormal urinary findings, such as sterile pyuria, proteinuria, and microscopic hematuria, are often seen in the acute phase of Kawasaki disease (KD). We investigated the potential significance of urinary lactate dehydrogenase (U-LDH) activity and its isozyme patterns in KD. Total U-LDH activity and its isozymes (U-LDH1-5) levels were compared among 120 patients with KD, 18 patients with viral infection (VI), and 43 patients with upper urinary tract infection (UTI) and additionally compared between intravenous immunoglobulin (IVIG) responders (n = 89) and nonresponders (n = 31) with KD. Read More

    Bradycardia Associated with Prednisolone in Children with Severe Kawasaki Disease.
    J Pediatr 2017 Mar 23. Epub 2017 Mar 23.
    Department of Cardiology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. Electronic address:
    Objective: To identify the prevalence of bradycardia associated with use of prednisolone in patients with Kawasaki disease and analyze the association between bradycardia and responsiveness to intravenous immunoglobulin (IVIG).

    Study Design: We performed a retrospective cohort study of 176 patients with severe Kawasaki disease admitted to the Tokyo Metropolitan Children's Medical Center between March 2010 and December 2015. The group treated with IVIG plus prednisolone therapy from February 2012 was compared with the control group who received IVIG monotherapy before this date. Read More

    An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator.
    BMC Neurosci 2017 Mar 24;18(1):35. Epub 2017 Mar 24.
    Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
    Background: Recent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson's disease, also meaningfully acts in the brain as a neuroregulator and affects social behaviors. It has been shown that social behaviors are impaired in CD157 knockout mice without severe motor dysfunction and that CD157/BST1 gene single nucleotide polymorphisms are associated with autism spectrum disorder in humans. However, it is still necessary to determine how this molecule contributes to the brain's physiological and pathophysiological functions. Read More

    NY-ESO-1 Protein Cancer Vaccine With Poly-ICLC and OK-432: Rapid and Strong Induction of NY-ESO-1-specific Immune Responses by Poly-ICLC.
    J Immunother 2017 Mar 23. Epub 2017 Mar 23.
    *Department of Gastroenterological Surgery †Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Suita ∥Department of Tumor Immunology, Drug Discovery and Disease Research Laboratory, Shionogi and Co. Ltd, Osaka ‡Department of Respiratory Medicine, Kawasaki Medical School **Faculty of Health and Welfare, Kawasaki University of Medical Welfare, Kurashiki, Okayama §Department of Pathology, Tokyo Medical University, Shinjuku-ku, Tokyo ¶Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan #Ludwig Institute for Cancer Research, New York, NY.
    We conducted a clinical trial of a cancer vaccine using NY-ESO-1 protein with polyinosinic-polycytidylic acid-poly-L-lysine carboxymethylcellulose (poly-ICLC) and/or OK-432 against solid tumors. A total of 15 patients were sequentially enrolled in 4 cohorts. Patients in cohort 1 received NY-ESO-1 protein; cohort 2a received NY-ESO-1 protein+OK-432; cohort 2b received NY-ESO-1 protein+poly-ICLC; cohort 3 received NY-ESO-1 protein+OK-432+poly-ICLC with Montanide ISA-51. Read More

    Tumor necrosis factor antagonist-induced psoriasis in a 3-year-old boy with Kawasaki disease.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Departments of Dermatology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York. Lauren.
    Tumor necrosis factor (TNF) antagonists have beenknown to trigger new-onset psoriasis in adult andpediatric patients. Here we report a case of TNFantagonist-induced psoriasis in a 3-year-old boytreated with infliximab for Kawasaki disease. Ourpatient is a 3-year-old boy with Kawasaki diseaseunresponsive to intravenous immunoglobulinwho was then treated with one dose of infliximab. Read More

    Giant aneurysms: A gender-specific complication of Kawasaki disease?
    J Cardiol 2017 Mar 18. Epub 2017 Mar 18.
    Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands.
    Background: Kawasaki disease (KD) is a pediatric vasculitis of unknown origin. Its main complication is the development of coronary artery aneurysms (CAA) with giant CAA at the end of the spectrum.

    Methods: In this cohort study, we evaluated the association between patient characteristics and the development of giant CAA based on z-scores. Read More

    [Sudden death of a young man as late sequelae complicating a pediatric disease: About a case].
    Ann Pathol 2017 Apr 18;37(2):188-192. Epub 2017 Mar 18.
    Service de médecine légale et droit de la santé, université d'Aix-Marseille, 264, rue Saint-Pierre, 13385 Marseille, France; Aix-Marseille université, CNRS, EFS, ADES UMR 7268, 13916 Marseille, France.
    In France, sudden death is responsible every year for 40,000 deaths. The most frequent etiology is cardiac disease. Atheromatous-related pathology is the most common etiology beyond 35, but cardiomyopathies and channelopathies are responsible for a significant number of deaths in young adults. Read More

    Distribution of Kawasaki Disease Coronary Artery Aneurysms and the Relationship to Coronary Artery Diameter.
    Pediatr Cardiol 2017 Mar 20. Epub 2017 Mar 20.
    Department of Pediatrics, Tokyo Teishin Hospital, Tokyo, Japan.
    We investigated how the diameter of coronary artery aneurysm (CAA) relates to the distribution immediately after Kawasaki disease (KD). Two hundred and four pts (155 males and 49 females) who had undergone selective coronary angiography (CAGs) less than 100 days after the onset of KD were studied. We measured the maximum diameter of each artery segment in the initial CAGs. Read More

    Refractory double-hit lymphoma/leukemia in childhood mimicking B-precursor acute lymphoblastic leukemia at initial presentation.
    Rinsho Ketsueki 2017 ;58(2):143-149
    Department of Hematology and Oncology, Children's Cancer Center, Kobe Children's Hospital.
    A 10-year-old girl was referred to our hospital with left preauricular adenopathy and gingival swelling. She was diagnosed with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) based on being positive for expressions of CD10, CD19, TdT and HLA-DR. She showed no CD20 expression at the time of diagnosis. Read More

    Predictors for intravenous immunoglobulin resistance and coronary artery lesions in Kawasaki disease.
    Pediatr Rheumatol Online J 2017 Mar 21;15(1):17. Epub 2017 Mar 21.
    Children's Hospital, Zhejiang University School of Medicine, No.57, Zhugan Lane, Hangzhou, 310003, People's Republic of China.
    Background: To assess the predictors for intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) in Kawasaki disease (KD).

    Methods: A total of 560 KD patients were reviewed retrospectively, including 410 complete KD (cKD) and 150 incomplete KD (iKD) patients. The laboratory data were compared between the IVIG-resistant and IVIG-responsive groups, as well as between the coronary artery lesions (CALs+) and without coronary artery lesions (CALs-) groups. Read More

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