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    [Gigantic aneurysm of the coronary artery].
    Arkh Patol 2017 ;79(5):21-24
    Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia.
    The paper describes a clinical case of gigantic aneurysm of one of the coronary arteries. It considers the morphological and immunohistochemical characteristics of the wall of the blood vessel with the detected signs of coronaritis. The authors have determined that Kawasaki disease could be retrospectively diagnosed in early childhood. Read More

    Surgical treatment of coronary artery aneurysms.
    J Card Surg 2017 Oct 13. Epub 2017 Oct 13.
    Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
    Introduction: Coronary artery aneurysms (CAA) are rare. We present our experience with the surgical treatment of patients with CAAs.

    Methods: Between March 2000 and October 2016, 15 patients with CAA underwent surgery. Read More

    Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia.
    Int J Hematol 2017 Oct 12. Epub 2017 Oct 12.
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Clinical outcomes and the genetic background of acute myeloid leukemia (AML) in adolescent and young adults (AYAs) are known to differ in younger children and older adults. To clarify the impact of genetic mutations on clinical outcomes of AYAs with AML, we analyzed data from the JPLSG AML-05 and JALSG AML201 studies. AYAs aged 15-39 years (n = 103) were included. Read More

    Prediction for Intravenous Immunoglobulin Resistance by Using Weighted Genetic Risk Score Identified From Genome-Wide Association Study in Kawasaki Disease.
    Circ Cardiovasc Genet 2017 Oct;10(5)
    From the Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy (H.-C.K., W.-C.C.), Department of Clinical Pharmacy, School of Pharmacy (H.S.-C.W., M.-S.W., W.-C.C.), School of Health Care Administration, College of Management (W.-P.C.), and PhD Program in Biotechnology Research and Development, College of Pharmacy (W.-C.C.), Taipei Medical University, Taiwan; Department of Pediatrics and Kawasaki Disease Center (H.-C.K., K.-S.H.), Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine (S.-F.L.), and Department of Respiratory Therapy (S.-F.L.), Kaohsiung Chang Gung Memorial Hospital, Taiwan; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan (B.-K.C.); Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan (B.-K.C.); Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan (K.D.Y.); Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan (K.D.Y.); The PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taiwan (Y.-W.H.); Section of Hematology/Oncology, Department of Medicine, The University of Chicago, IL (X.L.); Department of Pharmacy, Taipei Medical University-Wanfang Hospital, Taiwan (W.-C.C.); and Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Taiwan (W.-C.C.).
    Background: Intravenous immunoglobulin (IVIG) is the treatment of choice in Kawasaki disease (KD). IVIG is used to prevent cardiovascular complications related to KD. However, a proportion of KD patients have persistent fever after IVIG treatment and are defined as IVIG resistant. Read More

    Utility of osteosclerotic lesion biopsy in diagnosis of POEMS syndrome: A case report.
    Medicine (Baltimore) 2017 Oct;96(41):e8188
    aDepartment of Internal Medicine, Division of Neurology bDepartment of Diagnostic Pathology, Division of Diagnostic Pathology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
    Rationale: We report a case of successful diagnosis of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome based on monoclonality that was confirmed by an osteosclerotic lesion biopsy in a patient without pathognomonic symptoms or monoclonal gammopathy, probably because of comorbidities, which included systemic lupus erythematosus, rheumatoid arthritis, and Sjögren syndrome.

    Patient Concerns: A 57-year-old woman presented with an approximately 2-year history of numbness in the toes that had gradually spread, along with muscle weakness in both arms and legs. She had been receiving immunosuppressant and corticosteroid therapy since being diagnosed with systemic lupus erythematosus and Sjögren syndrome at the age of 31 years and rheumatoid arthritis at the age of 44 years. Read More

    Abnormalities of the Coronary Arteries in Children: Looking beyond the Origins.
    Radiographics 2017 Oct;37(6):1665-1678
    From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63110 (L.J.S., D.A.R., S.B.); Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, Ill (K.P.); Department of Cardiology, St Louis Children's Hospital, St Louis, Mo (T.A.R.); and Department of Radiology, Mercy Hospital, St Louis, Mo (E.F.S.).
    Coronary arterial abnormalities are uncommon findings in children that have profound clinical implications. Although anomalies of the coronary origins are well described, there are many other disease processes that affect the coronary arteries. Immune system-mediated diseases (eg, Kawasaki disease, polyarteritis nodosa, and other vasculiditides) can result in coronary arterial aneurysms, strictures, and abnormal tapering of the vessels. Read More

    Automatic digital quantification of bone marrow myeloma volume in appendicular skeletons - clinical implications and prognostic significance.
    Sci Rep 2017 Oct 10;7(1):12885. Epub 2017 Oct 10.
    Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.
    Multiple myeloma (MM) is a clonal plasma cell disorder originating in bone marrow. Whole body low-dose multidetector CT (MDCT) can depict bone marrow infiltration by myeloma cells into the adipose-rich fatty marrow of the appendicular skeleton. However, automated and objective volume measurement of bone marrow infiltration has not been established, and its clinical relevance remains unclear. Read More

    Treatment With Quadrivalent Human Papillomavirus Vaccine for Juvenile-Onset Recurrent Respiratory Papillomatosis: Case Report and Review of the Literature.
    J Pediatric Infect Dis Soc 2017 Aug 8. Epub 2017 Aug 8.
    Vaccine Education Center.
    Although juvenile-onset recurrent respiratory papillomatosis (JoRRP) generally involves a benign tumor on the larynx and other respiratory tract areas, almost all patients with this disease require repeated surgical intervention (to prevent airway obstruction during the course of illness) and various adjuvant therapies such as interferon, cidofovir, acyclovir, ribavirin, indole-3-carbinol, HspE7, mumps vaccine, photodynamic therapy, propranolol, cimetidine, and bevacizumab. Some case reports recently described the effectiveness of the quadrivalent human papillomavirus vaccine (HPV4) as an adjuvant therapy. On the basis of these reports, we administered HPV4 to a 2-year-old boy with JoRRP. Read More

    A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs).
    J Biochem 2017 Sep 4. Epub 2017 Sep 4.
    Department of Genome-based Drug Discovery.
    We developed a simplified and sensitive method to identify Alzheimer's disease (AD) biomarker candidates by a quantitative and targeted proteomic analysis (combination of liquid chromatography tandem mass spectrometry and multiplexed-multiple reaction monitoring/selected reaction monitoring analysis) of culture media from neurons differentiated from induced pluripotent stem cells (iPSCs) established from AD patients. We found that alpha-1-acid glycoprotein (ORM1) was decreased in the culture media of AD-iPSC-derived neurons, consistent with previous observations for AD patient cerebrospinal fluid, thus validating our new strategy. Moreover, our method is applicable for identifying biomarker candidates for other neurodegenerative disorders using patient-derived iPSCs. Read More

    Clinical and pathological findings in familial amyloid polyneuropathy caused by a transthyretin E61K mutation.
    J Neurol Sci 2017 Oct 12;381:55-58. Epub 2017 Aug 12.
    Department of Neurology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan.
    Familial amyloid polyneuropathy (FAP) is an autosomal dominant hereditary systemic amyloidosis caused by mutation of the transthyretin (TTR) gene, and usually shows sensory-dominant polyneuropathy and autonomic neuropathy at the initial stage. The pathogenesis of this neuropathy remains unknown, although several mechanisms, including mechanical compression, vessel occlusion, TTR toxicity and Schwann cell dysfunction have been proposed. We describe a patient with late-onset FAP caused by a TTR E61K mutation. Read More

    International Consensus Statement on the Clinical and Therapeutic Management of Leber's Hereditary Optic Neuropathy.
    J Neuroophthalmol 2017 Oct 3. Epub 2017 Oct 3.
    IRCCS Institute of Neurological Sciences of Bologna (VC, MC, CLM), Bellaria Hospital, Bologna, Italy; Unit of Neurology (VC, CLM), Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; Department of Neurology (IFdC), Erasmus Medical Center, Rotterdam, the Netherlands; Neuro-Ophthalmology Unit (AK), University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland; Department of Neurology (TK), Friedreich-Baur-Institute, Ludwing-Maximilians-University, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy) (TK), Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) (TK), Munich, Germany; Eye Center (WAL), Medical Center, Faculty of Medicine, University of Freiburg, Breisgau, Germany; Departments of Ophthalmology, Neurology and Neurological Surgery (NJN), Emory University School of Medicine, Atlanta, Georgia; Department of Ophthalmology (CO); Referral Center for Rare Diseases OPHTARA, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France; Department of Ophthalmology (JWRP), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Doheny Eye Institute (AAS), Los Angeles, California; Department of Ophthalmology (AAS), David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Neuro-ophthalmology (JvE), The Rotterdam Eye Hospital, Rotterdam, the Netherlands; Rotterdam Ophthalmic Institute (ROI) (JvE), Rotterdam, the Netherlands; Fondation Ophtalmologique Adolphe de Rothschild (CV-C), Paris, France; School of Optometry and Vision Sciences (MV), Cardiff University, and Cardiff Eye Clinic, University Hospital of Wales, Cardiff, United Kingdom; Wellcome Trust Center for Mitochondrial Research (PY-W-M), Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom; Newcastle Eye Center (PY-W-M), Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom; NIHR Biomedical Research Center at Moorfields Eye Hospital and UCL Institute of Ophthalmology (PY-W-M), London, United Kingdom; Department of Clinical Neurosciences (PY-W-M), School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom; Department of Ophthalmology (PB), San Raffaele Scientific Institute, Milan, Italy; and Studio Oculistico d'Azeglio (PB), Bologna, Italy.
    Leber hereditary optic neuropathy (LHON) is currently estimated as the most frequent mitochondrial disease (1 in 27,000-45,000). Its molecular pathogenesis and natural history is now fairly well understood. LHON also is the first mitochondrial disease for which a treatment has been approved (idebenone-Raxone, Santhera Pharmaceuticals) by the European Medicine Agency, under exceptional circumstances because of the rarity and severity of the disease. Read More

    Determination of miRNAs from Cancer Stem Cells Using a Low Density Array Platform.
    Methods Mol Biol 2018 ;1692:149-156
    Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Via L. De Crecchio 7, Naples, 80138, Italy.
    A microarray approach has been extensively used for global gene expression profiles in many biological research fields such as understanding of pathological mechanism in malignancies and defining of molecular biomarkers to monitor disease status. The most attractive advantage of microarray technology is its application to simultaneous analysis of miRNA expression pattern with a large amount of assessments. In this chapter, we provide a facile and universal protocol for divergent miRNA expression profiles in prostate cancer stem cells with a low density array-based microarray analysis. Read More

    Extracorporeal membrane oxygenation for Kawasaki disease: two case reports and the Extracorporeal Life Support Organization experience 1999-2015.
    Perfusion 2017 Oct 19;32(7):609-612. Epub 2017 Mar 19.
    1 Royal Children's Hospital, Melbourne, Australia.
    Kawasaki disease is usually a limited illness of early childhood. However, life-threatening cardiac manifestations can occur, either at acute presentation or as a consequence of coronary arterial involvement. We report the successful use of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) for cardiac support in two children with Kawasaki disease: one with acute Kawasaki disease shock syndrome, the other with complications of coronary arteritis and subsequent surgery. Read More

    Clinicopathological and genomic analysis of double-hit follicular lymphoma: comparison with high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.
    Mod Pathol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
    Most high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements are aggressive B-cell lymphomas. Occasional double-hit follicular lymphomas have been described but the clinicopathological features of these tumors are not well known. To clarify the characteristics of double-hit follicular lymphomas, we analyzed 10 cases of double-hit follicular lymphomas and 15 cases of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements for clinicopathological and genome-wide copy-number alterations and copy-neutral loss-of-heterozygosity profiles. Read More

    Outline of guidelines for the management of vasculitis and vascular disorders in Japan, 2016 revised edition.
    J Dermatol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Dermatology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
    The proposal by the 1994 International Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitides (CHCC1994) and by the CHCC2012 markedly influenced the classification and way of considering cutaneous vasculitis. In the proposal by the CHCC1994, hypersensitivity angiitis was defined as an equivalent pathological condition to microscopic polyangiitis or cutaneous leukocytoclastic angiitis (CLA), and it was not adopted as a disease name. However, CLA which was positioned as a type of small-vessel vasculitis is only a pathological name. Read More

    Evaluation of the accuracy of estimated baseline serum creatinine for acute kidney injury diagnosis.
    Clin Exp Nephrol 2017 Oct 5. Epub 2017 Oct 5.
    Kochi Medical School, Center of Medical Information Science, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan.
    Background: Modern epidemiologic studies of acute kidney injury (AKI) have been facilitated by the increasing availability of electronic medical records. However, pre-morbid reference serum creatinine (SCr) data are often unavailable in such records. Investigators substitute estimated baseline SCr with the eGFR 75 approach, instead of using actually measured baseline SCr. Read More

    The characteristics and outcomes of small bowel adenocarcinoma: a multicentre retrospective observational study.
    Br J Cancer 2017 Oct 5. Epub 2017 Oct 5.
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-Ku, Okayama 700-8558, Japan.
    Background: Small bowel adenocarcinoma (SBA) is a rare malignancy that accounts for 1-2% of gastrointestinal tumours. We investigated the clinical characteristics, outcomes, and prognostic factors of primary SBA.

    Methods: We retrospectively analysed the characteristics and clinical courses of 205 SBA patients from 11 institutions in Japan between June 2002 and August 2013. Read More

    Cognitive impairment associated with locomotive syndrome in community-dwelling elderly women in Japan.
    Clin Interv Aging 2017 12;12:1451-1457. Epub 2017 Sep 12.
    Department of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka, Osaka, Japan.
    In our worldwide aging society, elderly people should maintain cognitive and physical function to help avoid health problems. Dementia is a major brain disease among elderly people, and is caused by cognitive impairment. The locomotive syndrome (LS) refers to a condition in which people require healthcare services because of problems associated with locomotion. Read More

    Epigenetic hypomethylation and upregulation of matrix metalloproteinase 9 in Kawasaki disease.
    Oncotarget 2017 Sep 28;8(37):60875-60891. Epub 2017 Jul 28.
    Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Background: Kawasaki disease (KD) is a type of febrile coronary vasculitis occurring in children. Some researchers have suggested that changes in genetic signatures, such as matrix metalloproteinases (MMPs), are critical markers for cardiovascular diseases. This study aims to provide a comprehensive survey of global DNA methylation levels and MMP transcripts of KD patients compared to control subjects. Read More

    Survival significance of coexisting chronic obstructive pulmonary disease in patients with early lung cancer after curative surgery.
    Thorac Cancer 2017 Oct 4. Epub 2017 Oct 4.
    Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.
    Background: The impact of chronic obstructive pulmonary disease (COPD) severity on survival after curative resection of early-stage lung cancer (NSCLC) has not been sufficiently elucidated.

    Methods: We retrospectively reviewed 250 consecutive patients who underwent lobectomy with lymph nodal dissection for pathological stage I-II NSCLC.

    Results: Among the COPD patients, 28 were classified as Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1, 21 as GOLD 2, and one as GOLD 3. Read More

    A Phase 1/1b tolerability study of rilotumumab alone or in combination with cisplatin and capecitabine in Japanese patients with gastric cancer.
    Jpn J Clin Oncol 2017 Aug 22:1-8. Epub 2017 Aug 22.
    Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan.
    Objective: To evaluate the safety (including adverse events and dose-limiting toxicities [DLTs]), tolerability, pharmacokinetics and antitumor activity of the investigational MET inhibitor rilotumumab alone in patients with advanced solid tumors (Part 1) or in combination with cisplatin plus capecitabine (CX) in patients with MET-positive advanced gastric or gastroesophageal junction cancer (Part 2).

    Methods: Adult patients received 10 or 20 mg/kg intravenous (IV) rilotumumab every 2 weeks (Part 1) or 15 mg/kg IV rilotumumab every 3 weeks plus 80 mg/m2 cisplatin on Day 1 and 1000 mg/m2 capecitabine twice daily on Days 1-14 of every 21-day cycle (Part 2).

    Results: Nine patients enrolled in Part 1; 12 patients enrolled in Part 2. Read More

    Screening of differentially expressed genes associated with Kawasaki disease by microarray analysis.
    Exp Ther Med 2017 Oct 8;14(4):3159-3164. Epub 2017 Aug 8.
    Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China.
    Kawasaki disease (KD) is an autoimmune disorder that can induce coronary artery aneurysms, particularly in the case of delayed diagnosis and/or treatment. Early diagnosis is important for treatment and reduces the risk of heart injury. The aim of the present study was to identify differentially expressed genes by comparing the levels of gene expression in human umbilical vein endothelial cells following treatment with plasma from healthy individuals and patients with acute or convalescent KD. Read More

    Which cytokine is the most related to weight loss-‍induced decrease in arterial stiffness in overweight and obese men?
    Endocr J 2017 Sep 30. Epub 2017 Sep 30.
    Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
    Obesity and increased arterial stiffness are risk factors for cardiovascular disease. A well-known characteristic of obesity is the chronic low-grade inflammatory state, and it causes elevation of arterial stiffness. Weight-loss reduces arterial stiffness and inflammatory level in obese individuals. Read More

    Virus-Mimicking Chimaeric Polymersomes Boost Targeted Cancer siRNA Therapy In Vivo.
    Adv Mater 2017 Sep 29. Epub 2017 Sep 29.
    Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
    Small interfering RNA (siRNA) offers a highly selective and effective pharmaceutical for various life-threatening diseases, including cancers. The clinical translation of siRNA is, however, challenged by its short plasma life, poor cell uptake, and cumbersome intracellular trafficking. Here, cNGQGEQc peptide-functionalized reversibly crosslinked chimaeric polymersomes (cNGQ/RCCPs) is shown to mediate high-efficiency targeted delivery of Polo-like kinase1 specific siRNA (siPLK1) to orthotopic human lung cancer in nude mice. Read More

    Low risk of treatment resistance in Down syndrome with Kawasaki disease.
    Pediatr Int 2017 Sep 27. Epub 2017 Sep 27.
    Department of Pediatrics, Toho University Omori Medical Center.
    Background: Japanese nationwide survey reported that Down syndrome (DS) is less-frequently occurring comorbidity in Kawasaki disease (KD). Although altered immune responses are frequently observed in DS, no studies have focused treatment response and risk for coronary artery abnormalities (CAAs) in DS with KD. The aim of this study was to evaluate clinical manifestations, treatment response and proportion of CAAs in DS with KD. Read More

    Differences in Salivary Secretory Function between Patients with Erosive Esophagitis and Those with Nonerosive Reflux Disease.
    J Gastroenterol Hepatol 2017 Sep 27. Epub 2017 Sep 27.
    Division of Endoscopy and Ultrasonography, Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan.
    Background And Aim: It has been speculated that impaired salivary flow contributes to abnormal acid clearance in patients with erosive esophagitis (EE). For easy and objective assessment of salivary function, we developed a salivary gland blood flow measurement technique using continuous-wave Doppler sonography. In the present study, we evaluated the salivary secretory function in patients with EE and those with nonerosive reflux disease (NERD) using this method. Read More

    Myocardial Assessment in School-Aged Children with Past Kawasaki Disease.
    J Korean Med Sci 2017 Nov;32(11):1835-1839
    Division of Pediatric Cardiology, Department of Pediatrics, Gangnam Severance Hospital, Seoul, Korea.
    Coronary artery involvement remains the most important complication with Kawasaki disease (KD). Additional myocardial injury can be caused by inflammatory response and ischemic event. However, the long-term outcome of myocardial function has not been fully known in KD. Read More

    An update on the role of epigenetics in systemic vasculitis.
    Curr Opin Rheumatol 2017 Sep 27. Epub 2017 Sep 27.
    aDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA bDivision of Rheumatology, Faculty of Medicine, Marmara University, Istanbul, Turkey cCenter for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
    Purpose Of Review: The purpose of this review is to discuss recent observations of epigenetic changes related to the complex pathogenesis of systemic vasculitides and their contribution to the field.

    Recent Findings: There have been new observations of epigenetic changes in vasculitis and their potential role in disease pathogenesis in antineutrophil cytoplasmic antibody-associated vasculitis, giant-cell arteritis, Kawasaki disease, Behçet's disease, and IgA vasculitis. Some of this recent work has focused on the efficacy of using DNA methylation and miRNA expression as clinical biomarkers for disease activity and how DNA methylation and histone modifications interact to regulate disease-related gene expression. Read More

    Recurrence of Fever After Initial Intravenous Immunoglobulin Treatment in Children With Kawasaki Disease.
    Clin Pediatr (Phila) 2017 Feb 1:9922817694459. Epub 2017 Feb 1.
    2 National Research Institute for Child Health and Development, Tokyo, Japan.
    The standard treatment for Kawasaki disease (KD) is high-dose intravenous immunoglobulin (IVIG). Some patients experienced recurrent fever after IVIG following defervescence. However, little is known about the frequency of such episodes and the clinical outcome for such patients. Read More

    Clinical presentation of Legionella pneumonia: Evaluation of clinical scoring systems and therapeutic efficacy.
    J Infect Chemother 2017 Sep 23. Epub 2017 Sep 23.
    Research Division for Development of Anti-Infective Agents, Institute of Development, Aging and Cancer, Tohoku University, Japan.
    To evaluate scoring systems to predict Legionella pneumonia and therapeutic efficacy against Legionella pneumonia, the Japanese Society of Chemotherapy Legionella committee has collected data on cases of Legionella pneumonia from throughout Japan. We analyzed 176 patients with Legionella pneumonia and compared them with 217 patients with Streptococcus pneumoniae pneumonia and 202 patients with Mycoplasma pneumoniae pneumonia. We evaluated four scoring systems, the Winthrop-University Hospital score, Community-Based Pneumonia Incidence Study Group score, and Japan Respiratory Society score, but they demonstrated limited sensitivity and specificity for predicting Legionella pneumonia. Read More

    Pulmonary presentation of Kawasaki disease-A diagnostic challenge.
    Pediatr Pulmonol 2017 Sep 26. Epub 2017 Sep 26.
    Pulmonology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Objectives: Kawasaki disease (KD) is a multisystemic vasculitis with predominant mucocutaneous manifestations. Pulmonary involvement in KD is distinctly uncommon and is not commonly recognized. We describe our experience of managing children with KD wherein the initial presentation was predominantly pulmonary. Read More

    Mild cognitive impairment in older adults with pre-dialysis patients with chronic kidney disease: Prevalence and association with physical function.
    Nephrology (Carlton) 2017 Sep 26. Epub 2017 Sep 26.
    Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
    Aim: Chronic kidney disease (CKD) is a risk factor for declining cognitive and physical function. However, the prevalence of mild cognitive impairment (MCI) and its relationship with physical function is not clear. Therefore, our aim was to evaluate the prevalence of MCI and the relationship between MCI and physical function among older adults with pre-dialysis CKD. Read More

    Hand-spinning chrysotile exposure and risk of malignant mesothelioma: A case-control study in Southeastern China.
    Int J Cancer 2017 Sep 26. Epub 2017 Sep 26.
    Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang Province, China.
    While chrysotile has been commonly used by Chinese textile industry for many years, investigations on the association of chrysotile exposure with risk of mesothelioma in China are scarce. We conducted a case-control study in a county located at Southeastern China, including 46 cases and 230 individually matched controls. A semi-quantitative method based on experts' assessment was used for evaluating hand-spinning chrysotile exposure. Read More

    Vitamin D and Cardiovascular Risk in Children.
    Chin Med J (Engl) 2017 Sep 22. Epub 2017 Sep 22.
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
    Objective: Vitamin D is a group of fat-soluble molecules that are structurally similar to steroids. Emerging data have led to the hypothesis that Vitamin D plays a role in the regulation of many physiological processes beyond calcium and phosphorus homeostasis. With this review, we aimed to summarize the changes in Vitamin D levels in children with cardiovascular diseases based on the literature. Read More

    Characteristics of patients with increasing COPD assessment test scores within 3 years.
    Respir Med 2017 Oct 14;131:101-108. Epub 2017 Aug 14.
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
    Background: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a subjective measure of quality of life. The aim of this study was to examine the characteristics of COPD patients with increasing CAT scores within 3 years.

    Methods: Keio University and its affiliate hospitals conducted an observational COPD cohort study over 3 years. Read More

    Successful treatment using rituximab in a patient with refractory polymyositis complicated by scleroderma renal crisis.
    BMJ Case Rep 2017 Sep 23;2017. Epub 2017 Sep 23.
    Department of Rheumatology, Kawasaki Medical School, Kurashiki, Japan.
    Corticosteroids are the first-line treatment for patients with inflammatory myopathies. Myositis can be a clinical feature of scleroderma (polymyositis-scleroderma overlap syndrome), and treatment of this syndrome is a challenge for clinicians because moderate to high doses of corticosteroids are considered a risk factor for development of acute kidney injury in affected patients. We report here the case of a 56-year-old woman with scleroderma who developed polymyositis and was successfully treated with rituximab. Read More

    Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis.
    J Hepatobiliary Pancreat Sci 2017 Sep 23. Epub 2017 Sep 23.
    Department of Surgery, Institute of Gastroenterology Tokyo Women's Medical University, Tokyo, Japan.
    The initial management of patients with suspected acute biliary infection starts with the measurement of vital signs to assess whether or not the situation is urgent. If the case is judged to be urgent, initial medical treatment should be started immediately including respiratory/circulatory management if required, without waiting for the definitive diagnosis. The patient's medical history is then taken; an abdominal examination is performed; blood tests, urinalysis, and diagnostic imaging are carried out; and a diagnosis is made using the diagnostic criteria for cholangitis/cholecystitis. Read More

    Fever with Rashes.
    Indian J Pediatr 2017 Sep 23. Epub 2017 Sep 23.
    Department of Pediatrics, Pushpagiri Institute of Medical Sciences and Research Center, Thiruvalla, Kerala, India.
    Fever with rashes is one of the commonest clinical problems a general practitioner or pediatrician has to face in day-to-day clinical practice. It can be a mild viral illness or a life-threatening illness like meningococcemia or Dengue hemorrhagic fever or it can be one with a lifelong consequence like Kawasaki disease. It is very important to arrive at a clinical diagnosis as early as possible with the minimum investigational facilities. Read More

    Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Disease.
    Adv Exp Med Biol 2017 ;998:179-185
    Faculty of Medicine, The Department of Urology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Mesenchymal stem cells (MSCs) are multipotent stem cells that reside in various organs. They have the capacity to differentiate into various cell types, including cardiomyocytes, vascular endothelial cells, and vascular smooth muscle cells. Among the various MSCs, bone marrow-derived MSCs (BMMSCs) have been widely used for treating acute myocardial infarction (AMI) and ischemic heart failure (IHF) in preclinical and clinical studies. Read More

    Off-Pump Double Coronary Artery Bypass in a 14-Year-Old With Kawasaki Disease.
    Ann Thorac Surg 2017 Oct;104(4):e307-e309
    Department of Surgery, University of California, San Francisco-Fresno, Fresno, California; St. Agnes Medical Centre, Fresno, California. Electronic address:
    A 14-year-old male patient with a history of atypical Kawasaki disease at age 2 presents with triple vessel giant coronary aneurysms. Over the last several years, he began experiencing angina and dyspnea on exertion, which was a result of fully occluded right coronary and left circumflex arteries and 90% stenosis in the left anterior descending artery. He underwent off-pump coronary artery bypass using the left and right internal mammary arteries. Read More

    Mobilized Muse Cells After Acute Myocardial Infarction Predict Cardiac Function and Remodeling in the Chronic Phase.
    Circ J 2017 Sep 20. Epub 2017 Sep 20.
    Department of Cardiology, Gifu University Graduate School of Medicine.
    Background: Multilineage differentiating stress-enduring (Muse) cells are SSEA3(+)and CD105(+)double-positive pluripotent-like stem cells. We aimed to examine the mobilization of Muse cells into peripheral blood after acute myocardial infarction (AMI) and their effects on left ventricular (LV) function and remodeling.Methods and Results:In 79 patients with AMI, 44 patients with coronary artery disease (CAD), and 64 normal subjects (Control), we measured the number of Muse cells in the peripheral blood by fluorescence-activated cell sorting. Read More

    The prevention of coronary arterial abnormalities in Kawasaki disease: A meta-analysis of the corticosteroid effectiveness.
    J Microbiol Immunol Infect 2017 Sep 6. Epub 2017 Sep 6.
    Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taiwan. Electronic address:
    Objective: The use of corticosteroid in Kawasaki disease (KD) remains controversial among current guidelines. The objective of this study is to summarize the effectiveness and safety of corticosteroid to prevent coronary arterial lesions in Kawasaki disease, both as initial and rescue therapy.

    Methods: The Medline, EMBASE, Google scholar, Cochrane Central Register of Controlled Trials databases, ClinicalTrials. Read More

    The effects of storage temperature and duration of blood samples on DNA and RNA qualities.
    PLoS One 2017 19;12(9):e0184692. Epub 2017 Sep 19.
    Genomics and Proteomics Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    DNA and RNA samples from blood are the common examination target for non-invasive physical tests and/or biomedical studies. Since high-quality DNA and RNA samples guarantee the correctness of these tests and/or studies, we investigated the effects of storage temperature and storage duration of whole blood on DNA and RNA qualities. Subjects were enrolled to donate blood samples which were stored for different durations and at different temperatures, followed by the examinations on RNA quality, qPCR, DNA quality and DNA methylation. Read More

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