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    9730 results match your criteria Kawasaki Disease

    1 OF 195

    [Headaches in autoimmune diseases].
    Wiad Lek 2016 ;69(6):773-777
    Uniwersytet Medyczny w Lublinie, Polska.
    Vasculitides in autoimmune diseases are an important cause of secondary headaches. The article discusses the incidence of headache in primary and secondary vasculitides of the central nervous system. The symptoms of primary CNS vasculitis are presented. Read More

    Role of Antioxidants in Horse Serum-mediated Vasculitis in Swine: Potential Relevance to Early Treatment in Mitigation of Coronary Arteritis in Kawasaki Disease.
    Pediatr Neonatol 2016 Dec 18. Epub 2016 Dec 18.
    Division of Pediatric Cardiology, Department of Pediatrics, National Taiwan University Children's Hospital, National Taiwan University, Taipei, Taiwan.
    Background: Horse serum-induced immune complex coronary vasculitis in swine is the first experimental model to mimic most of the pictures of Kawasaki disease. Immune complex mechanism has been implicated as one of the possible mechanisms in the pathogenesis of vasculitis in Kawasaki disease. Antioxidants have a significant role in the reduction of cardiovascular diseases in both human and animal studies. Read More

    Prevention of chemotherapy-induced vomiting in children receiving multiple-day cisplatin chemotherapy: A hospital-based, retrospective cohort study.
    Pediatr Blood Cancer 2017 Feb 16. Epub 2017 Feb 16.
    Department of Hematology and Oncology, Children's Cancer Center, Kobe Children's Hospital, Kobe, Japan.
    Background: Optimal prevention of chemotherapy-induced vomiting (CIV) has not been established for patients receiving cisplatin in divided doses. The aim of this study was to describe the incidence and risk factors of CIV in children who received multiple-day cisplatin chemotherapy.

    Procedure: A total of 24 consecutive pediatric patients (age 0-19 years) who received multiple-day cisplatin chemotherapy in our hospital were enrolled. Read More

    The outcome of short-term low-dose aspirin treatment in Kawasaki disease based on inflammatory markers.
    Korean J Pediatr 2017 Jan 24;60(1):24-29. Epub 2017 Jan 24.
    Department of Pediatrics, Chungnam National University School of Medicine, Daejeon, Korea.
    Purpose: Previously, Kawasaki disease (KD) treatment with low-dose aspirin was administered for 6-8 weeks after the acute phase. However, inflammatory marker levels normalize before 6-8 weeks. In this study, we aimed to investigate the clinical outcome of short-term low-dose aspirin treatment based on inflammatory and thrombotic marker levels. Read More

    A case of sitosterolemia due to compound heterozygous mutations in ABCG5: clinical features and treatment outcomes obtained with colestimide and ezetimibe.
    Clin Pediatr Endocrinol 2017 Jan 31;26(1):17-23. Epub 2017 Jan 31.
    Department of Pediatrics, Kawasaki Medical School, Okayama, Japan.
    Sitosterolemia is a rare, autosomal recessively inherited disorder of lipid metabolism caused by mutations in the "ATP-binding cassette, subfamily G" member 5 and 8 proteins (encoded by the ABCG5 and ABCG8 genes, respectively), which play critical roles in the intestinal and biliary excretion of plant sterols. We report the clinical features and treatment outcomes of an 18-month-old Japanese girl with sitosterolemia, who presented with multiple linear and intertriginous xanthomas around the joint areas. Serum lipid analyses revealed elevated levels of total cholesterol (T-Chol: 866 mg/dL), low density lipoprotein-cholesterol (LDL-C: 679 mg/dL), and plant sterols (sitosterol: 24. Read More

    Peripheral Vitamin C Levels in Alzheimer's Disease: A Cross-Sectional Study.
    J Nutr Sci Vitaminol (Tokyo) 2016 ;62(6):432-436
    Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka.
    We previously reported lower lymphocyte vitamin C levels in individuals with type 2 diabetes mellitus and in individuals with severe Parkinson's disease. Oxidative stress has been proposed to play a key role in the progression of Alzheimer's disease. Thus, the objective of this study was to investigate the association between peripheral levels of vitamin C and the progression of cognitive dysfunction in Alzheimer's disease. Read More

    Cost-outcome description of PEG-IFN-α2b + RBV for hepatitis C: results based on the interferon database.
    Biol Pharm Bull 2017 Feb 15. Epub 2017 Feb 15.
    Department of Drug Evaluation & Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka.
    Economic evaluation of drugs is used in decision-making on medical care and public policy. Recently, real-world data (RWD) have been used in the analysis. In this study, we discuss the risk and benefits of using RWD for economic evaluation. Read More

    [Clinical and laboratory features of macrophage activation syndrome].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Feb;19(2):188-192
    Department of Rheumatology, Immunology and Allergy, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
    Objective: To study the clinical and laboratory features of macrophage activation syndrome (MAS) at the early stage of diagnosis, and to explore a method for early identification of MAS.

    Methods: A retrospective analysis was performed for the demographic data, clinical and laboratory features, and treatment outcomes of 21 MAS patients.

    Results: Of the 21 MAS patients, 14 had systemic juvenile idiopathic arthritis, 5 had Kawasaki disease (KD), and 2 had connective tissue disease (CTD) as primary diseases. Read More

    Effects of vaccine-acquired polyclonal anti-HBs antibodies on the prevention of HBV infection of non-vaccine genotypes.
    J Gastroenterol 2017 Feb 14. Epub 2017 Feb 14.
    Disease Biomarker Analysis and Molecular Regulation, St. Marianna University Graduate School of Medicine, 2-16-1, Sugao, Miyamae-Ku, Kawasaki, 216-8511, Japan.
    Background: In universal hepatitis B (HB) vaccination, single vaccine-derived polyclonal anti-HBs antibodies (anti-HBs) need to inhibit infection of HB viruses (HBV) of non-vaccine genotypes. We experimentally addressed this issue.

    Methods: Anti-HBs-positive sera were obtained by vaccination with genotype A- or C-derived HBs antigen (HBsAg, gtA-sera or gtC-sera). Read More

    Bone Marrow-Derived MicroRNA-223 Works as an Endocrine Genetic Signal in Vascular Endothelial Cells and Participates in Vascular Injury From Kawasaki Disease.
    J Am Heart Assoc 2017 Feb 14;6(2). Epub 2017 Feb 14.
    Children's Heart Center, The Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China
    Background: Kawasaki disease (KD) is now the most common cause of acquired cardiac disease in children due to permanent coronary artery damage with unknown etiology. The study sought to determine the role of blood microRNA miR-223 in KD and KD-induced injuries in vascular endothelial cells (ECs) as well as the mechanisms involved.

    Methods And Results: MicroRNA profiles in serum from patients with KD and from healthy controls were assessed by microarray analysis. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Predictive factors of resistance to intravenous immunoglobulin and coronary artery lesions in Kawasaki disease.
    Korean J Pediatr 2016 Dec 31;59(12):477-482. Epub 2016 Dec 31.
    Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea.
    Purpose: We conducted a study to determine which factors may be useful as predictive markers in identifying Kawasaki disease (KD) patients with a high risk of resistance to intravenous immunoglobulin (IVIG) and developing coronary artery lesions (CAL).

    Methods: We enrolled 287 patients in acute phase of KD at a single center. The demographic, clinical and laboratory data were collected retrospectively. Read More

    Usefulness of Calcium Scoring as a Screening Examination in Patients With a History of Kawasaki Disease.
    Am J Cardiol 2017 Jan 6. Epub 2017 Jan 6.
    Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California and Rady Children's Hospital San Diego, San Diego, California.
    Subsets of patients with a remote history of Kawasaki disease (KD) have coronary artery aneurysms with associated risks of late morbidity. In a pilot study, we previously showed that computed tomography (CT) coronary artery calcium (CAC) scoring detects late CAC in patients with aneurysms and a remote history of KD. We performed CT calcium volume scoring in 166 subjects (median age 19. Read More

    Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema.
    Anticancer Res 2017 02;37(2):765-771
    Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.
    Background: Chronic obstructive pulmonary disease is a smoking-related disease, and is categorized into the emphysema and airway dominant phenotypes. We examined the relationship between emphysematous changes and epidermal growth factor receptor (EGFR) mutation status in patients with lung adenocarcinoma.

    Patients And Methods: The medical records for 250 patients with lung adenocarcinoma were retrospectively reviewed. Read More

    Utility of Duranta, a wireless patch-type electrocardiographic monitoring system developed in Japan, in detecting covert atrial fibrillation in patients with cryptogenic stroke: A case report.
    Medicine (Baltimore) 2017 Feb;96(6):e5995
    Department of Neurology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
    Rationale: Subcutaneous implantable electrocardiographs are highly effective in detecting covert atrial fibrillation (AF) in cryptogenic stroke. However, these invasive devices are not indicated for all cryptogenic stroke patients, and noninvasive improvements over conventional Holter-type ambulatory electrocardiography are needed. We evaluated the clinical application and effectiveness of Duranta (ImageONE Co. Read More

    Aspiration thrombectomy and intracoronary tirofiban via GuideLiner(®) catheter for a thrombosed aneurysmal vessel.
    Future Cardiol 2017 Mar 7;13(2):131-135. Epub 2017 Feb 7.
    Department of Medicine, University of California, Irvine, 101 The City Drive, Suite #400, Orange, CA 92868, USA.
    A 52-year-old Asian male with no traditional risk factors for coronary artery disease presented with acute coronary syndrome. Coronary angiography showed complete thrombotic occlusion of the left circumflex with a large thrombus burden in the setting of diffuse aneurysmal enlargement of the coronary arteries consistent with antecedent Kawasaki disease. Manual thrombectomy with adjunctive intracoronary tirofiban was performed utilizing the GuideLiner catheter(®) (Vascular Solutions, Inc. Read More

    Non-receptor type, proline-rich protein tyrosine kinase 2 (Pyk2) is a possible therapeutic target for Kawasaki disease.
    Clin Immunol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Pediatric Cardiology and Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan. Electronic address:
    Kawasaki disease (KD) is a paediatric vasculitis whose pathogenesis remains unclear. Based on experimental studies using a mouse model for KD, we report here that proline-rich protein tyrosine kinase 2 (Pyk2) plays a critical role in the onset of KD-like murine vasculitis. The mouse model for KD was prepared by administrating a Candida albicans water-soluble fraction (CAWS). Read More

    18F-FDG PET/CT Imaging of Epididymal Smooth Muscle Mass Mimicking Recurrent Lymphoma.
    Clin Nucl Med 2017 Feb 3. Epub 2017 Feb 3.
    From the Department of Nuclear Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan.
    An 84-year-old man with a history of diffuse large B-cell lymphoma in remission who had completed chemotherapy 3 years previously was referred for imaging evaluation of disease recurrence. Abnormal accumulation in the left scrotum was demonstrated on F-FDG PET/CT. Subsequent ultrasonography showed a nodular mass lesion in the left epididymis. Read More

    Meta-analysis: Diagnostic Value of N-Terminal Pro-brain Natriuretic Peptide for Kawasaki Disease.
    Clin Lab 2016 Oct;62(10):1903-1910
    Background: Some studies have estimated the diagnostic value of N-terminal pro-brain natriuretic peptide (NTproBNP) for Kawasaki Disease (KD), but the results are not always consistent. The aim of this study was to ascertain the diagnostic value of NT-proBNP for KD.

    Methods: EMBSAE and PubMed were searched up to June 30, 2015, to identify eligible studies that evaluated the diagnostic value of NT-proBNP for KD. Read More

    Nationwide surveys show that the incidence of recurrent Kawasaki disease in Japan has hardly changed over the last 30 years.
    Acta Paediatr 2017 Feb 5. Epub 2017 Feb 5.
    Department of Public Health, Jichi Medical University, Tochigi, Japan.
    Aim: Since Kawasaki disease (KD) was first reported in 1967, its aetiology has been intensively investigated, but remains unclear. We investigated the incidence of recurrent KD in Japan in 2003-2012, compared to previous data from our team, and assessed the potential risk factors for disease recurrence.

    Methods: Data from nationwide KD surveys were retrospectively analysed and 81,310 patients were observed. Read More

    Cardiac magnetic resonance feature tracking in Kawasaki disease convalescence.
    Ann Pediatr Cardiol 2017 Jan-Apr;10(1):18-25
    Department of Cardiovascular Imaging, King's College London, London, United Kingdom.
    Objective: The objective of this study was to determine whether left ventricular (LV) myocardial deformation indices can detect subclinical abnormalities in Kawasaki disease convalescence. We hypothesized that subclinical myocardial abnormalities due to inflammation represent an early manifestation of the disease that persists in convalescence.

    Background: Myocardial inflammation has been described as a global finding in the acute phase of Kawasaki disease. Read More

    Genome-wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
    Gastroenterology 2017 Feb 2. Epub 2017 Feb 2.
    Department of Virology & Liver Unit. Electronic address:
    Background & Aims: There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with anti-viral agents. We investigated genetic factors associated with the development of HCC in patients with a sustained virologic response (SVR) to treatment for chronic HCV infection.

    Methods: We obtained genomic DNA from 457 patients in Japan with a SVR to interferon-based treatment for chronic HCV infection from 2007 through 2015. Read More

    Crosstalk between oxidative and nitrosative stress and arterial stiffness.
    Curr Vasc Pharmacol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicineand Pharmacy, Timisoara, Romania.
    Arterial stiffness, the expression of reduced arterial elasticity, is an effective predictor of cardiovascular disorders. Oxidative stress is an imbalance between exposure to toxic reactive oxygen species (ROS) and antioxidant systems. The increase in reactive nitrogen species (RNS) is termed nitrosative stress. Read More

    Kawasaki Disease with Fever and Cervical Lymphadenopathy as the Sole Initial Presentation.
    Korean Circ J 2017 Jan 23;47(1):107-114. Epub 2016 Dec 23.
    Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
    Background And Objectives: Some patients with Kawasaki disease (KD) present with fever and cervical lymphadenopathy alone. The purpose of this study was to characterize the clinical features of these unusual KD patients and determine whether this is a severe form of KD associated with increased risks of intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs).

    Subjects And Methods: A total of 146 children with KD were reviewed retrospectively, and classified into two groups according to initial clinical features. Read More

    Prognostic Significance of QT Interval Dispersion in the Response to Intravenous Immunoglobulin Therapy in Kawasaki Disease.
    Circ J 2017 Feb 1. Epub 2017 Feb 1.
    Department of Pediatrics, Shinshu University School of Medicine.
    Background: Kawasaki disease (KD) is classified as a systemic vasculitis syndrome and QT interval dispersion (QTD) has been associated with cardiac involvement and disease activity in patients with cardiovasculitis. We examined whether baseline QTD could predict a response to intravenous immunoglobulin (IVIG) in KD.Methods and Results:QTD was recorded in 86 patients with KD before IVIG, who were separated into IVIG responders (R group; n=62) and nonresponders (N group; n=24). Read More

    Development of Quality Metrics in Ambulatory Pediatric Cardiology.
    J Am Coll Cardiol 2017 Feb;69(5):541-555
    Department of Pediatrics, Harvard Medical School and Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
    The American College of Cardiology Adult Congenital and Pediatric Cardiology (ACPC) Section had attempted to create quality metrics (QM) for ambulatory pediatric practice, but limited evidence made the process difficult. The ACPC sought to develop QMs for ambulatory pediatric cardiology practice. Five areas of interest were identified, and QMs were developed in a 2-step review process. Read More

    Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility.
    PLoS One 2017 2;12(2):e0170977. Epub 2017 Feb 2.
    Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America.
    Kawasaki disease (KD) is the most common acquired pediatric heart disease. We analyzed Whole Genome Sequences (WGS) from a 6-member African American family in which KD affected two of four children. We sought rare, potentially causative genotypes by sequentially applying the following WGS filters: sequence quality scores, inheritance model (recessive homozygous and compound heterozygous), predicted deleteriousness, allele frequency, genes in KD-associated pathways or with significant associations in published KD genome-wide association studies (GWAS), and with differential expression in KD blood transcriptomes. Read More

    Characterization of a murine model with arteritis induced by Nod1 ligand, FK565: a comparative study with a CAWS-induced model.
    Mod Rheumatol 2017 Feb 2:1-19. Epub 2017 Feb 2.
    b Department of Pediatrics , Nippon Medical School , Tokyo , Japan.
    Objective: Kawasaki disease (KD) occurs via activation of the innate immune system. Nucleotide oligomerization domain -1 (NOD1) is a pattern recognition receptor regulating the innate immunity. We characterized histopathology of arteritis induced by FK565, a ligand for NOD1, in mice, compared with Candida albicans water-soluble fraction (CAWS)-induced model. Read More

    Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis.
    Sci Rep 2017 Feb 2;7:41539. Epub 2017 Feb 2.
    Department of Pediatric, Infectious diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    Interleukin-1β (IL-1β) is a highly inflammatory cytokine that significantly contributes to both acute and chronic inflammatory diseases. The secretion of IL-1β requires a unique protease, caspase-1, which is activated by various protein platforms called inflammasomes. Data suggests a key role for mitochondrial reactive oxygen species for inflammasome activation. Read More

    Expression of FcRs on monocytes among Kawasaki disease patients with coronary artery lesions.
    Int Immunopharmacol 2017 Jan 29;45:1-5. Epub 2017 Jan 29.
    Department of Rheumatology, Shenzhen Children's Hospital, Affiliated with Chongqing Medical University, China. Electronic address:
    Objective: To study expression of Fc gamma receptors (FcRs) on monocytes in Kawasaki disease (KD) patients with coronary artery lesions (CAL).

    Methods: 160 newly diagnosed KD patients and 80 health children were enrolled in this study. All patients were scheduled to receive both aspirin and intravenous immunoglobulin (IVIG). Read More

    Effect of evacuation on liver function after the Fukushima Daiichi Nuclear Power Plant accident: The Fukushima Health Management Survey.
    J Epidemiol 2017 Jan 27. Epub 2017 Jan 27.
    Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima, Japan; Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
    Background: The Great East Japan Earthquake and subsequent Fukushima Daiichi Nuclear Power Plant accident caused residents to switch from their normal lives to lives focused on evacuation. We evaluated liver function before and after this disaster to elucidate the effects of evacuation on liver function.

    Methods: This study was a longitudinal survey of 26,006 Japanese men and women living near the Fukushima Daiichi Nuclear Power Plant. Read More

    Dengue Fever Triggering Kawasaki Disease.
    Indian Pediatr 2017 Jan;54(1):51-52
    Department of Pediatrics, University College of Medical Sciences, Dilshad Garden, Delhi, India. Correspondence to: Dr Piyush Gupta, Block R6A, Dilshad Garden, Delhi 110 095, India.
    Background: Several bacterial and viral infections are listed as triggering factors for Kawasaki disease; association with dengue fever is rare.

    Case Characteristics: A 5-year-old girl who presented with fever that was confirmed to be dengue fever, and subsequently improved, except that the fever persisted. She fulfilled diagnostic criteria for Kawasaki disease on day 7 of fever. Read More

    A randomised, phase III trial of once-daily fluticasone furoate/vilanterol 100/25 μg versus once-daily vilanterol 25 μg to evaluate the contribution on lung function of fluticasone furoate in the combination in patients with COPD.
    Respir Med 2017 Feb 2;123:8-17. Epub 2016 Dec 2.
    GlaxoSmithKline, Research Triangle Park, NC, USA.
    Background: The contribution of fluticasone furoate (FF) on lung function in the FF/vilanterol (VI) 100/25 μg combination has been demonstrated numerically, but not statistically.

    Methods: This multicentre, randomised, double-blind, controlled trial (GlaxoSmithKline study number 200820; clinicaltrials.gov NCT02105974) enrolled ≥40-year-old patients with chronic obstructive pulmonary disease (COPD), a ≥10-pack-year smoking history, a post-bronchodilator forced expiratory volume in 1 s (FEV1) 30-70% of the predicted value, a FEV1/forced vital capacity ratio of ≤0. Read More

    [A Resected Case of Cecal Cancer with Simultaneous Liver, Spleen, and Ovarian Metastasis and Peritoneal Dissemination].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2447-2449
    Dept. of Surgery, Nara Medical University.
    We herein report the case of a patient with a cecal cancer with simultaneous liver, spleen, and ovarian metastases as well as peritoneal dissemination who achieved a long-term survival. The patient was a 67-year-old female. Ileocecal resection with partial hepatectomy, splenectomy, simple total hysterectomy, bilateral salpingo-oophorectomy, and resection of the peritoneal dissemination were performed. Read More

    [A Case of Disseminated Peritoneal Leiomyomatosis with Several Recurrences].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1690-1692
    Dept. of Surgery, Aomori Prefectural Central Hospital.
    A 60's woman had undergone abdominal total hysterectomy due to uterine leiomyoma 17 years previously. She underwent resection of multiple intra-abdominal tumors 9 years previously, and was diagnosed with disseminated peritoneal leiomyomatosis. Because of several recurrences, she was referred to our hospital and treated with GnRH agonist therapy. Read More

    [Analysis of Treatment and Outcomes in Locally Advanced Breast Cancer].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1496-1498
    Dept. of Breast and Endocrine Surgery, Japanese Red Cross Okayama Hospital.
    Current treatment guidelines for locally advanced breast cancers recommend multimodality therapy consisting of chemotherapy followed by local treatment(surgery and radiotherapy). We retrospectively analyzed 35 cases oflocally advanced breast cancer at our institution between January 2004 and December 2014. Nine patients(25. Read More

    Corticosteroids for the treatment of Kawasaki disease in children.
    Cochrane Database Syst Rev 2017 Jan 27;1:CD011188. Epub 2017 Jan 27.
    Congenital Heart Disease, Bristol Royal Hospital for Children and Bristol Heart Institute, Upper Maudlin Street, Bristol, UK, BS2 8BJ.
    Background: Kawasaki disease (KD), or mucocutaneous syndrome, is the leading cause of childhood-acquired heart disease in the developed world. There is much controversy on how best to treat children with KD and in particular who may benefit from additional treatment beyond the standard intravenous immunoglobulin (IVIG) and aspirin, such as the addition of corticosteroids.

    Objectives: To assess the impact of corticosteroid use on the incidence of coronary artery abnormalities in KD as either first-line or second-line treatment. Read More

    Persistent prevalence of polycythemia among evacuees 4 years after the Great East Japan Earthquake: A follow-up study.
    Prev Med Rep 2017 Mar 12;5:251-256. Epub 2017 Jan 12.
    Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University School of Medicine, Fukushima, Japan.
    We previously reported that the lifestyle of evacuees significantly increased the prevalence of polycythemia compared with non-evacuees at an average of 1.6 years (2011-2012) from the previous annual health checkup before the Great East Japan Earthquake (GEJE). Here we analyzed how the prolonged evacuation affected the prevalence of polycythemia an average of 2. Read More

    Association of erythrocyte methotrexate-polyglutamate levels with the efficacy and hepatotoxicity of methotrexate in patients with rheumatoid arthritis: a 76-week prospective study.
    RMD Open 2017 3;3(1):e000363. Epub 2017 Jan 3.
    Division of Rheumatology, Department of Internal Medicine , Keio University School of Medicine , Tokyo , Japan.
    Objective: To assess the utility of erythrocyte methotrexate-polyglutamate (MTX-PG) concentrations in determining the safety and efficacy of MTX in patients with rheumatoid arthritis (RA).

    Methods: 79 MTX-naïve patients with RA were enrolled in this prospective 76-week cohort study. MTX was initiated, and a predefined dose-escalation protocol was followed. Read More

    Correlation of symptomatic enterovirus infection and later risk of allergic diseases via a population-based cohort study.
    Medicine (Baltimore) 2017 Jan;96(4):e5827
    aDepartment of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Taiwan bDepartment of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taiwan cDepartment of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Infants who are exposed to the rhinovirus or respiratory syncytial virus are at a higher risk of subsequently developing wheezing or asthma. This study aims to determine whether preschoolers with a history of symptomatic enterovirus infection are at an increased risk of developing allergic diseases or not.We used data from the Taiwan National Health Insurance Research Database from 1999 to 2006 for this nationwide population-based cohort study. Read More

    Immediate adverse reactions to intravenous immunoglobulin in children: a single center experience.
    Eur Ann Allergy Clin Immunol 2017 Jan;49(1):11-14
    Kanuni Sultan Suleyman Research and Training Hospital, Department of Pediatric Allergy-Immunology, Istanbul, Turkey. E-mail:
    Intravenous immunoglobulin (IVIG) is commonly used in primary and secondary immunodeficiency diseases as well as autoimmune conditions as immunomodulatator treatment. Immediate adverse events which are generally mild and occur during infusion are seen in 6 hours. Reported immediate adverse events are in a wide range from 1%-40% in pediatric patients. Read More

    Controlling Tumor Progression with Cyclophosphamide, Vincristine, and Dacarbazine Treatment Improves Survival in Patients with Metastatic and Unresectable Malignant Pheochromocytomas/Paragangliomas.
    Horm Cancer 2017 Jan 20. Epub 2017 Jan 20.
    Division of Endocrinology, Metabolism and Hypertension, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1, Mukaihatacho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.
    Evidence has not been established to support that combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine (CVD) improves survival in patients with malignant pheochromocytoma and paraganglioma (M-PPGL). To investigate the efficacy of CVD for this disease, we retrospectively analyzed data of 23 patients with metastatic and unresectable M-PPGL (mean age, 41.7 ± 15. Read More

    Relationship between IL-27 and coronary arterial lesions in children with Kawasaki disease.
    Clin Exp Med 2017 Jan 20. Epub 2017 Jan 20.
    Department of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, People's Republic of China.
    Kawasaki disease (KD) arises due to the disorder of the inflammation response and faulty immune regulation. Interleukin-27 (IL-27) is a novel cytokine with both pro-inflammatory and anti-inflammatory effects. This study investigated the relationship between serum levels of IL-27, Interleukin-17A (IL-17A), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and coronary artery lesions (CALs) in patients with KD. Read More

    Ischemic stroke in Kawasaki disease.
    Pediatr Int 2017 Jan;59(1):92-96
    Division of Pediatric Cardiology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Pediatric stroke is considered to be rare. Stroke resulting from cerebral vasculitis is also uncommon in young children. With the increasing prevalence of Kawasaki disease (KD) diagnosis, this acquired vasculitis has been reported with various clinical presentations including neurological symptoms. Read More

    Kawasaki Shock Syndrome in a 12-Year-Old Girl Mimicking Septic Shock.
    Case Rep Infect Dis 2016 22;2016:4949036. Epub 2016 Dec 22.
    Professorial Paediatric Unit, Colombo South Teaching Hospital, Kalubowila, Sri Lanka.
    Kawasaki disease is diagnosed when fever lasts for more than 5 days with the presence of four out of five of the following clinical features: bilateral conjunctival congestion, changes in the lips and oral cavity, polymorphous exanthem, changes in peripheral extremities, and acute nonpurulent cervical lymphadenopathy (Nakamura et al., 2012). The average age of onset is 2 years and 90% of patients are below 5 years of age. Read More

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