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    Tumor necrosis factor antagonist-induced psoriasis in a 3-year-old boy with Kawasaki disease.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Departments of Dermatology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York. Lauren.
    Tumor necrosis factor (TNF) antagonists have beenknown to trigger new-onset psoriasis in adult andpediatric patients. Here we report a case of TNFantagonist-induced psoriasis in a 3-year-old boytreated with infliximab for Kawasaki disease. Ourpatient is a 3-year-old boy with Kawasaki diseaseunresponsive to intravenous immunoglobulinwho was then treated with one dose of infliximab. Read More

    Giant aneurysms: A gender-specific complication of Kawasaki disease?
    J Cardiol 2017 Mar 18. Epub 2017 Mar 18.
    Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands.
    Background: Kawasaki disease (KD) is a pediatric vasculitis of unknown origin. Its main complication is the development of coronary artery aneurysms (CAA) with giant CAA at the end of the spectrum.

    Methods: In this cohort study, we evaluated the association between patient characteristics and the development of giant CAA based on z-scores. Read More

    [Sudden death of a young man as late sequelae complicating a pediatric disease: About a case].
    Ann Pathol 2017 Mar 18. Epub 2017 Mar 18.
    Service de médecine légale et droit de la santé, université d'Aix-Marseille, 264, rue Saint-Pierre, 13385 Marseille, France; Aix-Marseille université, CNRS, EFS, ADES UMR 7268, 13916 Marseille, France.
    In France, sudden death is responsible every year for 40,000 deaths. The most frequent etiology is cardiac disease. Atheromatous-related pathology is the most common etiology beyond 35, but cardiomyopathies and channelopathies are responsible for a significant number of deaths in young adults. Read More

    Distribution of Kawasaki Disease Coronary Artery Aneurysms and the Relationship to Coronary Artery Diameter.
    Pediatr Cardiol 2017 Mar 20. Epub 2017 Mar 20.
    Department of Pediatrics, Tokyo Teishin Hospital, Tokyo, Japan.
    We investigated how the diameter of coronary artery aneurysm (CAA) relates to the distribution immediately after Kawasaki disease (KD). Two hundred and four pts (155 males and 49 females) who had undergone selective coronary angiography (CAGs) less than 100 days after the onset of KD were studied. We measured the maximum diameter of each artery segment in the initial CAGs. Read More

    Refractory double-hit lymphoma/leukemia in childhood mimicking B-precursor acute lymphoblastic leukemia at initial presentation.
    Rinsho Ketsueki 2017 ;58(2):143-149
    Department of Hematology and Oncology, Children's Cancer Center, Kobe Children's Hospital.
    A 10-year-old girl was referred to our hospital with left preauricular adenopathy and gingival swelling. She was diagnosed with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) based on being positive for expressions of CD10, CD19, TdT and HLA-DR. She showed no CD20 expression at the time of diagnosis. Read More

    Predictors for intravenous immunoglobulin resistance and coronary artery lesions in Kawasaki disease.
    Pediatr Rheumatol Online J 2017 Mar 21;15(1):17. Epub 2017 Mar 21.
    Children's Hospital, Zhejiang University School of Medicine, No.57, Zhugan Lane, Hangzhou, 310003, People's Republic of China.
    Background: To assess the predictors for intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) in Kawasaki disease (KD).

    Methods: A total of 560 KD patients were reviewed retrospectively, including 410 complete KD (cKD) and 150 incomplete KD (iKD) patients. The laboratory data were compared between the IVIG-resistant and IVIG-responsive groups, as well as between the coronary artery lesions (CALs+) and without coronary artery lesions (CALs-) groups. Read More

    Sets of serum exosomal microRNAs as candidate diagnostic biomarkers for Kawasaki disease.
    Sci Rep 2017 Mar 20;7:44706. Epub 2017 Mar 20.
    Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China.
    Although Kawasaki disease is the main cause of acquired heart disease in children, no diagnostic biomarkers are available. We aimed to identify candidate biomarkers for diagnosing Kawasaki disease using serum exosomal microRNAs (miRNAs). Using frozen serum samples from a biobank, high-throughput microarray technologies, two-stage real-time quantitative PCR, and a self-referencing strategy for data normalization, we narrowed down the list of biomarker candidates to a set of 4 miRNAs. Read More

    Afebrile Kawasaki disease with coronary artery dilatation.
    Pediatr Int 2017 Mar;59(3):375-377
    Department of Microbiology and Immunology, Saitama Children's Medical Center, Saitama City, Saitama, Japan.
    Herein we describe the cases of two afebrile patients who were thought to have Kawasaki disease (KD). Patient 1 was a 7-month-old-Japanese girl. She presented with bulbar conjunctival injection, diarrhea, skin erythema, and redness around the bacillus Calmette-Guerin (BCG) inoculation site. Read More

    Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
    Ann Rheum Dis 2017 Mar 17. Epub 2017 Mar 17.
    Rheumatology A Department, INSERM U1016/UMR 8104, Cochin Institute, Paris Descartes University, Paris, France.
    Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by skin and systemic fibrosis culminating in organ damage. Previous genetic studies including genome-wide association studies (GWAS) have identified 12 susceptibility loci satisfying genome-wide significance. Transethnic meta-analyses have successfully expanded the list of susceptibility genes and deepened biological insights for other autoimmune diseases. Read More

    Surgical Resection for Pulmonary Metastasis from Pancreatic and Biliary Tract Cancer.
    Anticancer Res 2017 Mar;37(3):1413-1416
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Aim: To determine the efficacy of pulmonary metastasectomy for pancreatic and biliary tract cancer.

    Patients And Methods: Ten patients who underwent therapeutic pulmonary metastasectomy after resection for pancreatic and biliary tract cancer at our Institution from 2006 to 2016 were retrospectively evaluated.

    Results: The primary site was the pancreas in four patients and biliary tract in six. Read More

    Fistula and Survival Outcomes after Fistula Creation among Predialysis Chronic Kidney Disease Stage 5 Patients.
    Am J Nephrol 2017 Mar 17;45(4):356-364. Epub 2017 Mar 17.
    Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
    Background: Most guidelines recommend the creation of arteriovenous fistula (AVF) in patients with chronic kidney disease (CKD) stage 4. However, an increasing number of studies suggest that early AVF creation leads to high rates of AVF failure and death before dialysis commencement. Only the Japanese guideline recommends AVF creation at CKD stage 5; however, no data are available regarding access-related outcomes at this stage. Read More

    The impact of evacuation on the incidence of chronic kidney disease after the Great East Japan Earthquake: The Fukushima Health Management Survey.
    Clin Exp Nephrol 2017 Mar 15. Epub 2017 Mar 15.
    Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
    Background: About 146,000 people were forced into long-term evacuation due to the nuclear power plant accident caused by the Great East Japan Earthquake in 2011. Disaster is known to induce hypertension in survivors for a certain period, but it is unclear whether prolonged disaster stress influences chronic kidney disease (CKD). We conducted an observational cohort study to elucidate the effects of evacuation stress on CKD incidence. Read More

    Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration.
    N Engl J Med 2017 03;376(11):1038-1046
    From the Division of Ophthalmology, Institute of Biomedical Research and Innovation Hospital, Foundation for Biomedical Research and Innovation (M.M., Y. Kurimoto, Y.H., M.F., M.Y., S. Ohta, M. Takahashi), Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology (M.M., C.M., H.A., N.S., Y.S., M. Terada, H.K., S.S., A.O., M.Y., M. Takahashi), the Department of Ophthalmology, Kobe City Medical Center General Hospital (Y.Kurimoto, Y.H., M.F.), the Department of Clinical Trial Management, Institute of Biomedical Research and Innovation Hospital, Foundation for Biomedical Research and Innovation (T.I., K.F.), and Research and Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation (S.K., M.J.G.), Kobe, Center for iPS Cell Research and Application (CiRA) (A.W., Y.N., M.N., J.K., Y. Kitano, N.A., M.U., F.K., A.T., N.T., S.Y.), Institute for Integrated Cell-Material Sciences (iCeMS) (A.W.), and Department of Pathology and Tumor Biology, Graduate School of Medicine (K.Y., S. Ogawa), Kyoto University, Kyoto, the Department of Biostatistics, Hyogo College of Medicine, Nishinomiya (T.D.), Platform of Therapeutics for Rare Disease, National Institutes of Biomedical Innovation, Health, and Nutrition, Ibaraki (H.A.), Mitsubishi Space Software, Tokyo (S.T., Y.O., C.O.), the Department of Ophthalmology, Kawasaki Medical School, Kurashiki (H.K.), Japan Tissue Engineering, Gamagori (C.S., K.H.), and HEALIOS K.K., Tokyo (M.S.) - all in Japan; and Gladstone Institute of Cardiovascular Disease, San Francisco (S.Y.).
    We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular age-related macular degeneration. The iPSCs were generated from skin fibroblasts obtained from two patients with advanced neovascular age-related macular degeneration and were differentiated into RPE cells. The RPE cells and the iPSCs from which they were derived were subject to extensive testing. Read More

    Relationship between serum sodium level and coronary artery abnormality in Kawasaki disease.
    Korean J Pediatr 2017 Feb 27;60(2):38-44. Epub 2017 Feb 27.
    Division of Pediatric Nephrology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
    Purpose: Kawasaki disease (KD) is an immune-related multisystemic vasculitis that occurs in children, especially ensuing from a coronary artery abnormality. Sodium level is known to be related to vascular injury, which could affect the progress of KD. The purpose of this study was to determine the serum sodium levels that could predict the occurrence of cardiac and coronary artery events in KD. Read More

    Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside.
    Gene 2017 Mar 7. Epub 2017 Mar 7.
    Foundation for Advancement of International Science, 24-16, Kasuga, 3-chome, Tsukuba, Ibaraki 305-0821, Japan; Ishida Group of Clock Gene, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8566, Japan; Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8576, Japan. Electronic address:
    Gaucher's disease in humans is considered a deficiency of glucocerebrosidase (GlcCerase) that result in the accumulation of its substrate, glucocerebroside (GlcCer). Although mouse models of Gaucher's disease have been reported from several laboratories, these models are limited due to the perinatal lethality of GlcCerase gene. Here, we examined phenotypes of Drosophila melanogaster homologues genes of the human Gaucher's disease gene by using Minos insertion. Read More

    Prognostic factors for gastrectomy in elderly patients with gastric cancer.
    World J Surg Oncol 2017 Mar 11;15(1):59. Epub 2017 Mar 11.
    Department of Digestive Surgery, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.
    Background: The aim of the present study was to investigate the age-specific prognostic factors in patients who underwent gastrectomy for gastric cancer.

    Methods: The medical records of 366 patients with gastric cancer who underwent surgical resection at our hospital between January 2007 and December 2014 were retrospectively reviewed. Of the 366 patients, 117 were aged 75 years or older and 249 were aged 74 years or younger. Read More

    Asia-Pacific Consensus Guidelines for Endoscopic Management of Benign Biliary Strictures.
    Gastrointest Endosc 2017 Mar 7. Epub 2017 Mar 7.
    Department of Gastroenterology & Endoscopy, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China.
    Benign biliary strictures (BBSs) are commonly caused by surgical injury, chronic pancreatitis, and inflammatory cholangiopathies. Although advanced imaging tests and tissue acquisition methods have been developed for evaluation of indeterminate biliary strictures, differentiation of BBSs from biliary malignancies remains a challenge to clinicians. The majority of BBSs have good response to nonsurgical treatment and surgical intervention mainly serves as a rescue when nonsurgical approaches fail. Read More

    Olfactory function in neuropsychiatric disorders.
    Psychiatry Res 2017 Mar 2;252:175-179. Epub 2017 Mar 2.
    Department of Neuropsychiatry, Kanazawa Medical University, Ishikawa, Japan.
    Recent clinical studies have identified olfactory dysfunction in patients with neuropsychiatric disorders. Although these studies showed differences in olfactory function between healthy individuals and neuropsychiatric patients, no studies have compared the differences in olfactory function among neuropsychiatric disorders. The aim of the present study was to investigate olfactory function among various neuropsychiatric disorders. Read More

    Effect of Tenofovir Disoproxil Fumarate on Incidence of Chronic Kidney Disease and Rate of Estimated Glomerular Filtration Rate Decrement in HIV-1-Infected Treatment-Naïve Asian Patients: Results from 12-Year Observational Cohort.
    AIDS Patient Care STDS 2017 Mar;31(3):105-112
    1 AIDS Clinical Center, National Center for Global Health and Medicine , Tokyo, Japan .
    Little evidence is available for the incidence of chronic kidney disease (CKD) and rate of estimated glomerular filtration rate (eGFR) decrement among Asians with low body weight who are susceptible to tenofovir disoproxil fumarate (TDF) nephrotoxicity. In this 12-year observational cohort in Tokyo, we examined 1383 treatment-naïve HIV-1-infected Asians [720 started TDF-containing (TDF group) and 663 started non-TDF-containing (control) combination antiretroviral therapy (cART)]. The CKD incidence was calculated, and the effect of TDF use on CKD development was estimated using logistic regression. Read More

    BCG and Kawasaki disease in Mexico and Japan.
    Hum Vaccin Immunother 2017 Mar 10:1-3. Epub 2017 Mar 10.
    d Department of Clinical Immunology , Instituto Nacional de Pediatría, Insurgentes Cuicuilco Coyoacan , Mexico City , Mexico.
    Dr. Tomisaku Kawasaki was the first to describe BCG reactivation in Kawasaki Disease (KD), and this sign is present in about 30-50% of KD patients. It is a very specific early sign of the disease and although it has been recognized for decades, its pathophysiology continues to be an enigma. Read More

    Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery.
    J Biomater Sci Polym Ed 2017 Mar 12:1-15. Epub 2017 Mar 12.
    e Innovation Center of NanoMedicine, Institute of Industry Promotion-KAWASAKI , Kawasaki , Japan.
    Surface functionalization of nanoparticles is a crucial factor for nanoparticle-mediated drug and nucleic acid delivery. Particularly, the density of targeting ligands on nanoparticle significantly affects the affinity of nanoparticles to specific cellular surface (or receptor) through the multivalent binding effect. Herein, multilayered polyion complexes (mPICs) are prepared to possess varying densities of cyclic RGD peptide (cRGD) ligands for cancer-targeted small interfering RNA (siRNA) delivery. Read More

    Efficacy of long-term omalizumab therapy in patients with severe asthma.
    Respir Investig 2017 Mar 21;55(2):114-120. Epub 2016 Dec 21.
    Division of Respiratory Disease, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan. Electronic address:
    Background: The efficacy of omalizumab, an anti-immunoglobulin E (IgE) antibody, has been studied in patients with severe bronchial asthma. We conducted a study to evaluate, on the basis of both objective and subjective measures, the efficacy of omalizumab as a long-term therapy in patients with severe and persistent asthma.

    Methods: Omalizumab was administered subcutaneously every two or four weeks. Read More

    Difficult diagnosis of atypical kawasaki disease in an infant younger than six months: a case report.
    Ital J Pediatr 2017 Mar 8;43(1):30. Epub 2017 Mar 8.
    Department of Pediatrics, "Sapienza" University of Rome, V.le Regina Elena 324, 00161, Rome, Italy.
    Background: Kawasaki disease (KD) is an acute inflammatory vasculitis of unknown origin.

    Case Presentation: We report the case of a 5-month-old child with an atypical form of KD, characterized by undulating symptoms, who developed an aneurysm of the right coronary artery and an ectasia of the left anterior descending coronary artery.

    Conclusion: This case report underlines the difficulties in recognizing incomplete forms of the illness in young infants, who are at higher risk of cardiac complications. Read More

    Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults.
    Nutrients 2017 Mar 5;9(3). Epub 2017 Mar 5.
    Department of Foods and Nutrition, College of Natural Sciences, Dongduk Women's University, Seoul 02748, Republic of Korea.
    Hypertension is a complex disease explained with diverse factors including environmental factors and genetic factors. The objectives of this study were to determine the interaction effects between gene variants and 24 h estimated urinary sodium and potassium excretion and sodium-potassium excretion ratios on the risk of hypertension. A total of 8839 participants were included in the genome-wide association study (GWAS) to find genetic factors associated with hypertension. Read More

    Recent mass spectrometry-based proteomics for biomarker discovery in lung cancer, COPD, and asthma.
    Expert Rev Proteomics 2017 Apr 17;14(4):373-386. Epub 2017 Mar 17.
    a Department of Translational Medicine Informatics , St. Marianna University School of Medicine, Miyamae-ku , Kawasaki , Japan.
    Introduction: Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease. Recent developments in mass spectrometry (MS) have made it possible to analyze disease-relevant proteins expressed in clinical specimens by proteomic challenges. Read More

    Mycoplasma Infection as a cause of Persistent Fever after Intravenous Immunoglobulin Treatment of Patients with Kawasaki Disease: Frequency and Clinical Impact.
    Infect Chemother 2017 Feb 28. Epub 2017 Feb 28.
    Department of Pediatrics, Kyung Hee University Hospital, Seoul, Korea.
    Background: Mycoplasma is a common cause of respiratory infections and may require differential diagnosis from Kawasaki disease (KD). In this study, we investigated the frequency and clinical manifestations of mycoplasma infection in patients with KD.

    Materials And Methods: Medical records of 375 in-patients admitted for treatment during the acute stage of KD, were collected, and reviewed retrospectively. Read More

    Pediatric follicular lymphoma in Japan.
    Int J Hematol 2017 Mar 7. Epub 2017 Mar 7.
    Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan.
    Follicular lymphoma (FL) is quite rare in children. There have been only two major reports on pediatric FL. The present retrospective study on pediatric FL in Japan, including FL with diffuse large B cell lymphoma (DLBCL), analyzed data from 1991 to 2014. Read More

    Deep feature learning for automatic tissue classification of coronary artery using optical coherence tomography.
    Biomed Opt Express 2017 Feb 30;8(2):1203-1220. Epub 2017 Jan 30.
    Dept. of Computer Engineering, École Polytechnique de Montréal, Montréal, Canada.
    Kawasaki disease (KD) is an acute childhood disease complicated by coronary artery aneurysms, intima thickening, thrombi, stenosis, lamellar calcifications, and disappearance of the media border. Automatic classification of the coronary artery layers (intima, media, and scar features) is important for analyzing optical coherence tomography (OCT) images recorded in pediatric patients. OCT has been known as an intracoronary imaging modality using near-infrared light which has recently been used to image the inner coronary artery tissues of pediatric patients, providing high spatial resolution (ranging from 10 to 20 μm). Read More

    Histological evaluations of apatite-fiber scaffold cultured with mesenchymal stem cells by implantation at rat subcutaneous tissue.
    Biomed Mater Eng 2017 ;28(1):57-64
    Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.
    Background: There is a strong impetus for the development of alternative treatments for bone disease that avoid the complications associated with autografts and allografts. To address this, we previously developed porous apatite-fiber scaffolds (AFSs) which have three-dimensional interconnected pores, and constructed tissue-engineered bone by culturing rat bone marrow cells (RBMCs) using AFSs in a radial-flow bioreactor (RFB).

    Objective: To generate additional baseline data for the development of tissue-engineered bone constructed for clinical application using a RFB, we cultured RBMCs using AFSs under static conditions (hereafter, RBMC AFS culture), and monitored RBMC growth and differentiation characteristics in vitro, and two weeks after subcutaneous inoculation into recipient rats. Read More

    Genetic analyses of the fusion protein genes in human parainfluenza virus types 1 and 3 among patients with acute respiratory infections in Eastern Japan from 2011 to 2015.
    J Med Microbiol 2017 Feb;66(2):160-168
    4​Infectious Disease Surveillance Center, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, Tokyo 208-0011, Japan 7​Department of Molecular Biodefence Research, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa 236-0004, Japan.
    Purpose: To genetically explore the fusion protein gene (F) in human parainfluenza virus type 1 (HPIV1) and type 3 (HPIV3) strains, we analysed them in patients with acute respiratory infections in Eastern Japan from 2011 to 2015.

    Methodology: We constructed phylogenetic trees based on the HPIV and HPIV3 F gene using the maximum likelihood method and conducted P-distance and selective pressure analyses. We also predicted the linear epitopes of the protein in the prototype strains. Read More

    Extremely refractory Kawasaki disease with disseminated intravascular coagulation.
    Cardiol Young 2017 Mar 7:1-4. Epub 2017 Mar 7.
    Department of Pediatrics,Chosun University School of Medicine,Gwangju,Republic of Korea.
    Disseminated intravascular coagulation is a rare complication of Kawasaki disease and appears in <0.1% of Kawasaki disease patients. We report a case of refractory Kawasaki disease complicated with disseminated intravascular coagulation and giant coronary aneurysm. Read More

    Improvement of metabolic disorders by an EP(2) receptor agonist via restoration of the subcutaneous adipose tissue in pulmonary emphysema.
    Prostaglandins Other Lipid Mediat 2017 Mar 2;130:16-22. Epub 2017 Mar 2.
    Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuou, Ami, Inashiki, Ibaraki 300-0395, Japan. Electronic address:
    Chronic obstructive pulmonary disease (COPD) is often associated with co-morbidities. Metabolic disorders like hyperlipidemia and diabetes occur also in underweight COPD patients, although the mechanism is uncertain. Subcutaneous adipose tissue (SAT) plays an important role in energy homeostasis, since restricted capacity to increase fat cell number with increase in fat cell size occurring instead, is associated with lipotoxicity and metabolic disorders. Read More

    Identification of candidate diagnostic serum biomarkers for Kawasaki disease using proteomic analysis.
    Sci Rep 2017 Mar 6;7:43732. Epub 2017 Mar 6.
    Department of Pediatrics, Yokohama City University Medical Center, Yokohama, Japan.
    Kawasaki disease (KD) is a systemic vasculitis and childhood febrile disease that can lead to cardiovascular complications. The diagnosis of KD depends on its clinical features, and thus it is sometimes difficult to make a definitive diagnosis. In order to identify diagnostic serum biomarkers for KD, we explored serum KD-related proteins, which differentially expressed during the acute and recovery phases of two patients by mass spectrometry (MS). Read More

    Phosphoproteome analysis of synoviocytes from patients with rheumatoid arthritis.
    Int J Rheum Dis 2017 Mar 5. Epub 2017 Mar 5.
    Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan.
    Aim: To explore disease-associated molecules in rheumatoid arthritis (RA), we comprehensively analyzed phosphoproteins purified from RA synoviocytes.

    Method: Synoviocytes were obtained from three patients with RA and three patients with osteoarthritis (OA). Profiles of phosphoproteins purified from the synoviocytes were compared by two-dimensional differential gel electrophoresis (2D-DIGE) between the RA and OA groups. Read More

    Kawasaki disease and immunisation: A systematic review.
    Vaccine 2017 Mar 2;35(14):1770-1779. Epub 2017 Mar 2.
    Monash Children's Hospital, Clayton, Melbourne, Australia; Murdoch Childrens Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, Monash University, Clayton, Victoria, Australia; Department of Paediatrics, Melbourne University, Parkville, Victoria, Australia.
    Background: Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation.

    Methods: We conducted a systematic literature review using various reference sources to review the available evidence published in the literature. Read More

    Detection of Norovirus GII.17 Kawasaki 2014 in Shellfish, Marine Water and Underwater Sewage Discharges in Italy.
    Food Environ Virol 2017 Mar 3. Epub 2017 Mar 3.
    Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, viale Regina Elena 299, 00161, Rome, Italy.
    Norovirus (NoV) is a major cause of non-bacterial acute gastroenteritis worldwide, and the variants of genotype GII.4 are currently the predominant human strains. Recently, a novel variant of NoV GII. Read More

    Topics in histopathology of sweat gland and sebaceous neoplasms.
    J Dermatol 2017 Mar;44(3):315-326
    Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki City, Japan.
    This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Read More

    Disruption of Endothelial Cell Homeostasis Plays a Key Role in the Early Pathogenesis of Coronary Artery Abnormalities in Kawasaki Disease.
    Sci Rep 2017 Mar 3;7:43719. Epub 2017 Mar 3.
    Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
    Disruption of endothelial cell homeostasis may be associated with the pathogenesis of coronary artery abnormalities (CAA) in Kawasaki disease (KD). We sought to clarify the poorly understood pathogenic role of endothelial cell survival and death in KD vasculitis. Human umbilical vein endothelial cells (HUVECs) stimulated with sera from KD patients, compared with sera from patients with bacterial infections, exhibited significant increases in cytotoxicity, high mobility group box protein 1 (HMGB-1), and caspase-3/7 and a decrease in phosphorylated Akt/Akt (pAkt/Akt) ratios. Read More

    Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly(l-lysine) block copolymers as systemic gene delivery carrier.
    Biomaterials 2017 May 20;126:31-38. Epub 2017 Feb 20.
    Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan; Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan. Electronic address:
    Structural stability of polyplex micelles (PMs), prepared from plasmid DNA (pDNA) and poly(ethylene glycol)-b-poly(l-lysine) block catiomer (PEG-PLys), was evaluated in terms of their resistance against shear stress. When exposed to shear stress at magnitudes typically present in the blood stream, structural deterioration was observed in PMs owing to the partial removal of PEG-PLys strands. Eventually, impaired PEG coverage of the polyplex core led to accelerated degradation by nucleases, implying that structural deterioration by shear stress in blood stream may be a major cause of rapid clearance of PMs from blood circulation. Read More

    C-reactive protein, symptoms and activity of daily living in patients with advanced cancer receiving palliative care.
    J Cachexia Sarcopenia Muscle 2017 Mar 1. Epub 2017 Mar 1.
    Department of Palliative Medicine, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
    Background: The association between C-reactive protein (CRP) level, symptoms, and activities of daily living (ADL) in advanced cancer patients is unclear.

    Methods: Secondary data analysis of a multicenter prospective cohort study consisted of 2426 advanced cancer patients referred to palliative care settings was conducted to examine the cross-sectional relationships between CRP level, symptoms, and ADL disabilities. Laboratory data, symptoms, ADL, and manual muscle testing (MMT) results were obtained at baseline. Read More

    Rotavirus vaccine and health-care utilization for rotavirus gastroenteritis in Tsu City, Japan.
    Western Pac Surveill Response J 2016 Oct-Dec;7(4):28-36. Epub 2016 Nov 14.
    Department of Pediatrics, Kawasaki Medical School, Kurashiki, Japan .
    Background: Rotavirus vaccines were introduced in Japan in November 2011. We evaluated the subsequent reduction of the health-care burden of rotavirus gastroenteritis.

    Methods: We conducted active surveillance for rotavirus gastroenteritis among children under 5 years old before and after the vaccine introduction. Read More

    Caution in Generalizing the Use of Adjunctive Primary Corticosteroids in Kawasaki Disease to Unselected Non-Japanese Populations-Reply.
    JAMA Pediatr 2017 Feb 20. Epub 2017 Feb 20.
    Department of Cardiology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China3Department of Cardiology, Allgemein öffentliches Krankenhaus Elisabethinen, Linz, Austria 4K. H. Elisabethinen Associated University Teaching Hospital of Medical University Innsbruck, Vienna, Austria.

    Functional hemispherotomy in Rasmussen syndrome in the absence of classic MRI findings.
    Epilepsy Behav Case Rep 2017 5;7:24-27. Epub 2016 Dec 5.
    Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
    A 7-year-old previously healthy girl presented with a left-sided focal seizure without impaired consciousness and subsequently developed epilepsia partialis continua. Initial MRI was normal, and the subsequent images only showed a focal T2/FLAIR hyperintense area without cortical atrophy. She was diagnosed with Rasmussen syndrome by pathology and promptly treated with functional hemispherotomy. Read More

    [Kawasaki disease is more prevalent in rural areas of Catalonia (Spain)].
    An Pediatr (Barc) 2017 Feb 23. Epub 2017 Feb 23.
    Institut Català de Ciències del Clima (IC3), Barcelona, España.
    Introduction: Kawasaki disease (KD) is an acute self-limited systemic vasculitis relatively common in childhood. The etiology of KD is still unknown, although clinical, laboratory and epidemiological features suggest an infectious origin or trigger. Differences on incidence between countries have been related to specific genetic factors, ethnicity, country of birth and some other sociocultural and environmental factors. Read More

    Accumulation of immunoglobulin G against Dermatophagoides farinae tropomyosin in dorsal root ganglia of NC/Nga mice with atopic dermatitis-like symptoms.
    Biochem Biophys Res Commun 2017 Apr 24;485(4):707-712. Epub 2017 Feb 24.
    Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, Japan; Department of Dermatology, Juntendo University, Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, Japan. Electronic address:
    Atopic dermatitis (AD), a chronic inflammatory skin disease, manifests as intractable itch, but its underlying mechanisms are poorly understood. This study assessed the relationship between immunoglobulin G (IgG) and dorsal root ganglia (DRG) in NC/Nga mice, a model of AD that manifests AD-like symptoms including itch. Immunohistochemical analysis showed large amounts of IgG in DRG extracts of NC/Nga mice with AD-like dermatitis, with a large fraction of the IgG distributed in satellite glial cells of the DRG. Read More

    Regression and Complications of z-score-Based Giant Aneurysms in a Dutch Cohort of Kawasaki Disease Patients.
    Pediatr Cardiol 2017 Feb 24. Epub 2017 Feb 24.
    Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Centre (AMC), Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
    Kawasaki disease (KD) is a pediatric vasculitis. Its main complication is the development of coronary artery aneurysms (CAA), with giant CAA at the end of the spectrum. We evaluated regression and event-free rates in a non-Asian cohort of patients with giant CAA using the current z-scores adjusted for body surface area instead of absolute diameters. Read More

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