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Pediatr Int 2019 Feb 20. Epub 2019 Feb 20.

Department of Public Health, Jichi Medical University, Shimotsuke, Japan.

Background: Approximately 50 years have passed since Kawasaki disease (KD) was first reported. The Kawasaki disease nationwide survey began in 1970. Although more than 360,000 patients have already been reported in Japan, the cause is still unknown. Read More

J Med Internet Res 2019 Feb 20;21(2):e10450. Epub 2019 Feb 20.

Institute for Research Initiatives, Nara Institute of Science and Technology, Ikoma, Japan.

Background: Health-related social media data are increasingly used in disease-surveillance studies, which have demonstrated moderately high correlations between the number of social media posts and the number of patients. However, there is a need to understand the causal relationship between the behavior of social media users and the actual number of patients in order to increase the credibility of disease surveillance based on social media data.

Objective: This study aimed to clarify the causal relationships among pollen count, the posting behavior of social media users, and the number of patients with seasonal allergic rhinitis in the real world. Read More

Cardiol Young 2019 Feb;29(2):178-184

1Department of Children's Heart Center,The Second Affiliated Hospital and Yuying Children's Hospital,Institute of Cardiovascular Development and Translational Medicine,Wenzhou Medical University,Wenzhou,China.

Objective: This study was performed to explore the clinical features of Kawasaki disease shock syndrome and analyse the association between the left ventricular ejection fraction and Kawasaki disease shock syndrome.

Methods: We retrospectively reviewed the medical records of all consecutive inpatients with Kawasaki disease at Wenzhou Medical University Second Affiliated Hospital and Yuying Children's Hospital in Wenzhou, China from January 2009 to December 2016. We compared the clinical characteristics, laboratory data, and left ventricular ejection fraction between patients with and without Kawasaki disease shock syndrome and analysed the effect of the left ventricular ejection fraction on Kawasaki disease shock syndrome under different clinical conditions of Kawasaki disease. Read More

Int J Clin Oncol 2019 Feb 18. Epub 2019 Feb 18.

Cancer Center, Aichi Medical University, Aichi, Japan.

Background: The reintroduction of oxaliplatin as a third-or-later-line regimen has been a promising option for patients with metastatic colorectal cancer (mCRC) who previously received chemotherapy including oxaliplatin. In this single-arm phase II study, we evaluated the efficacy of biweekly SOX, which is the combination of oxaliplatin reintroduction and S-1, as a third-or-later-line treatment.

Methods: Patients with mCRC who had previously received prior chemotherapy including oxaliplatin and irinotecan and were planned to receive the reintroduction of oxaliplatin were enrolled. Read More

Front Pediatr 2019 4;7. Epub 2019 Feb 4.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Kawasaki disease (KD) is anacute febrile coronary vasculitis disease in children. In general, this disease can be treated with a single dose of 2 g/kg intravenous immunoglobulin (IVIG). However, the best timing for administering steroid treatment in acute-stage KD is still under debate. Read More

JMIR Mhealth Uhealth 2019 Feb 19;7(2):e12694. Epub 2019 Feb 19.

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Background: Mobile apps have been considered to provide active and continuous support for smoking cessation. However, it is yet to be known whether a smoking cessation smartphone app improves long-term abstinence rates in nicotine-dependent patients.

Objective: This study aimed to evaluate the long-term abstinence effect of a novel smartphone app, CureApp Smoking Cessation (CASC), in patients with nicotine dependence. Read More

Korean J Pediatr 2019 Feb 19. Epub 2019 Feb 19.

Department of Pediatrics, Institute of Health Science, Gyeongsang National University College of Medicine, Jinju, Korea.

Arch Med Sci Atheroscler Dis 2018 21;3:e41-e45. Epub 2018 Mar 21.

Department of Pediatrics, Robert Reid Cabral Children's Hospital affiliated to the University Iberoamericana UNIBE, School of Medicine, Santo Domingo, Dominican Republic.

Kawasaki disease is an acute systemic vasculitis that was first reported in 1961. Over the last 5 decades multiple papers have been published to further understand this disease. The diagnosis of Kawasaki disease is made based on the clinical findings. Read More

Circulation 2019 Feb 18. Epub 2019 Feb 18.

Department of Nephrology and Hypertension, Kawasaki Medical School, Japan.

Background: Sodium glucose cotransporter 2 (SGLT2) inhibitors may reduce kidney hyperfiltration, thereby preventing diabetic kidney disease (DKD) progression, which may in turn reduce cardiovascular risk, including heart failure. However, the mechanisms that regulate renal function responses to SGLT2 inhibition are not yet fully understood. We explored the renal protective effects of SGLT2 inhibition with empagliflozin (Empa), with a focus on glomerular hemodynamic effects and tubuloglomerular feedback (TGF) using in vivo multiphoton microscope (MPM) imaging techniques. Read More

J Neurosurg Pediatr 2019 Feb 15:1-4. Epub 2019 Feb 15.

1Department of Neurosurgery, Division of Clinical Neurosciences.

OBJECTIVEKawasaki disease (KD) is a vasculitis that can cause aneurysm formation in coronary arteries and, more rarely, in peripheral arteries. A possible connection between KD and intracranial aneurysms is unclear. The purpose of this study was to determine if KD is associated with intracranial aneurysms. Read More

Clin Exp Nephrol 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, St. Marianna University School of Medicine, Kawasaki, Japan.

Purpose: To assess the safety and effectiveness of transcatheter arterial embolization (TAE) with tris-acryl gelatin microspheres for patients with symptomatic enlarged polycystic liver disease (PCLD).

Materials And Methods: This prospective study was approved by our hospital's institutional review board and planned for patients with symptoms related to enlarged PCLD, such as distended abdomen, gastrointestinal obstruction and abdominal pain. Hemi-hepatic embolization with tris-acryl gelatin microspheres was performed in the hepatic artery supplying the hepatic lobe that showed the predominant presence of cysts. Read More

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; Institute of Rheumatology, Tokyo Women's Medical University; Department of Orthopedic Surgery, Juntendo University School of Medicine; Division of Rheumatology, Department of Rheumatology, Keio University School of Medicine, Tokyo; Department of Orthopedic Surgery, Shiga University of Medical Science, Shiga; Department of Rheumatology, Tonan Hospital, Hokkaido; Department of Orthopedic Surgery, Fujita Health University, Aichi; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo; Department of Rheumatology, Chubu Rosai Hospital, Aichi; Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi; Department of Orthopedics, Osaka Minami Medical Center, Osaka; Department of Rheumatology, Daido Hospital, Aichi; Department of Internal Medicine, Juntendo University Koshigaya Hospital, Saitama; Department of Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine, Osaka, Japan; departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Division of Rheumatology, National University Hospital, Singapore; Division of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan; Hospital Universitario Reina Sofía/IMIBIC/University of Córdoba, Córdoba, Spain; Department of Rheumatology, Paris Descartes University, Cochin Hospital, Paris, France; INSERM Unit 1183, CRESS, Paris, France; Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. This study was conducted under the umbrella of the International Society for Spondyloarthritis Assessment (ASAS) and the COMOSPA study was supported by the unrestricted grants from Pfizer, AbbVie, and UCB. M.K. received honoraria from AbbVie and Ayumi; K.Y. receives tuition support from Harvard T.H. Chan School of Public Health (partially supported by training grants from Pfizer, Takeda, Bayer, and PhRMA); A.M. has received research grants from Abbvie, Pfizer, and MSD. M. Kishimoto, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; K. Yoshida, MD, MPH, ScD, Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health; N. Ichikawa, MD, Institute of Rheumatology, Tokyo Women's Medical University; H. Inoue, MD, Department of Orthopedic Surgery, Juntendo University School of Medicine; Y. Kaneko, MD, Division of Rheumatology, Department of Rheumatology, Keio University School of Medicine; T. Kawasaki, MD, Department of Orthopedic Surgery, Shiga University of Medical Science; K. Matsui, MD, Department of Rheumatology, Tonan Hospital, M. Morita, MD, Department of Orthopedic Surgery, Fujita Health University; M. Suda, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; K. Tada, MD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; N. Takizawa, MD, Department of Rheumatology, Chubu Rosai Hospital; N. Tamura, MD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; A. Taniguchi, MD, Institute of Rheumatology, Tokyo Women's Medical University; Y. Taniguchi, MD, Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School; S. Tsuji, MD, Department of Orthopedics, Osaka Minami Medical Center; Y. Haji, MD, Department of Rheumatology, Daido Hospital; R. Rokutanda, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; H. Yanaoka, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; P.P. Cheung, MD, Division of Rheumatology, National University Hospital; J. Gu, MD, Division of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; T.H. Kim, MD, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases; S.F. Luo, MD, Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital and Chang Gung University; M. Okada, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; C. López Medina, MD, Hospital Universitario Reina Sofía/IMIBIC/University of Córdoba; A. Molto, MD, Department of Rheumatology, Paris Descartes University, Cochin Hospital, and INSERM Unit 1183, CRESS; M. Dougados, MD, Department of Rheumatology, Paris Descartes University, Cochin Hospital, and INSERM Unit 1183, CRESS; S. Kobayashi, MD, PhD, Department of Internal Medicine, Juntendo University Koshigaya Hospital; D. van der Heijde, MD, Department of Rheumatology, Leiden University Medical Center; T. Tomita, MD, Department of Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine. Address correspondence to Dr. M. Kishimoto, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University, 9-1 Akashicho, Chuo-ku, Tokyo, Japan, 104-8560. E-mail: Accepted for publication October 11, 2018.

Objective: To delineate clinical characteristics of patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world.

Methods: Using the ASAS-COMOSPA (Assessment of Spondyloarthritis international Society-COMOrbidities in SPondyloArthritis) data, an international cross-sectional observational study of patients with SpA, we analyzed information on demographics, disease characteristics, comorbidities, and risk factors. Patients were classified by region: Japan, other Asian countries (China, Singapore, South Korea, Taiwan), and non-Asian countries (Europe, the Americas, Africa). Read More

J Card Fail 2019 Feb 12. Epub 2019 Feb 12.

Department of Cardiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. Electronic address:

Background: The (pro)renin receptor [(P)RR)] is involved in the activation of local renin-angiotensin system and subsequent development of cardiovascular disease. We investigated the therapeutic effect of a (P)RR blocker, handle region peptide (HRP), on chronic kidney disease (CKD)-associated heart failure.

Methods And Results: CKD was induced in C57BL/6J mice by 5/6 nephrectomy. Read More

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

Objectives: Adult-onset Still's disease (AOSD) is an inflammatory disorder characterised by sustained fevers, arthritis, and skin involvement. Interstitial lung disease (ILD) is a rare manifestation, and its clinical characteristics have yet to be determined.

Methods: We sought to examine the clinical characteristics of AOSD-associated ILD. Read More

Western Pac Surveill Response J 2018 Oct-Dec;9(4):21-27. Epub 2018 Dec 20.

Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.

Outbreaks of infectious diseases can occur after natural disasters as vital services are disrupted and populations move into evacuation centres. National notifiable disease surveillance may be inadequate in these situations because of resource-consuming disease confirmation or system interruptions. Although syndromic surveillance has been used as an alternative in post-disaster situations, no systematic evaluations of it have been published. Read More

Ann Rheum Dis 2019 Feb 14. Epub 2019 Feb 14.

Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

Medicine (Baltimore) 2019 Feb;98(7):e14395

The First Hospital of Jilin University, Changchun.

Rationale: Kawasaki disease (KD), which is also known as mucocutaneous lymphnode syndrome, is a vasculitic disease and involves multi-system disorder with various clinical manifestations. KD is specific predilection for the coronary arteries and is the most common cause of childhood-acquired heart disease in developed countries. KD is rarely complicated by cranial nerve VII palsy. Read More

Psychogeriatrics 2019 Feb 13. Epub 2019 Feb 13.

Departments of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Front Pediatr 2019 30;7:11. Epub 2019 Jan 30.

Pediatric Cardiology Unit, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Kawasaki disease is an acute vasculitis with a particular involvement of the coronary arteries. Coronary artery aneurysms develop in 20% of untreated children. It has been shown that early treatment with intravenous immunoglobulins and aspirin decreases this risk to 5%, but the medium to long term prognosis of children with Kawasaki disease is still unclear. Read More

FEBS Open Bio 2019 Feb 20;9(2):265-275. Epub 2018 Dec 20.

Department of Cardiology Beijing Children's Hospital Capital Medical University Beijing China.

Kawasaki disease (KD) is an acute systemic vasculitis that mainly afflicts infants and young children. The symptoms of KD are similar to those of various febrile diseases. Here, we attempted to develop accurate diagnostic biomarkers of KD by performing urine proteomic analysis of samples from healthy controls, patients with KD, and patients with another febrile disease, pneumonia (two patients). Read More

Dermatol Ther 2019 Feb 13:e12854. Epub 2019 Feb 13.

Department of Dermatology, Yildirim Beyazit University, Medical School, Ankara, Turkey.

Intravenous immunoglobulins are therapeutic products, comprising polyclonal IgGs, which are obtained from human plasma pool of healthy blood donors. Despite the lack of FDA approval, the experience of using IVIG in various dermatological diseases increases day by day and exciting results are reported. However, experience with the use of IVIG in dermatological indications are mostly case reports whereas randomized, controlled, double-blind, multicentric studies have not been performed. Read More

Indian J Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, The CHILDS Trust Medical Research Foundation, 12-A, Nageswara Road, Nungambakkam, Chennai, Tamilnadu, 600034, India.

J Infect Chemother 2019 Feb 7. Epub 2019 Feb 7.

Kawasaki City Institute for Public Health, Japan.

Background: Even though abnormal behavior related with influenza and neuraminidase inhibitors (NI) has been discussed, the risks of acetaminophen and co-administration of NI and acetaminophen have not been examined. This study assesses those risks.

Materials And Methods: All cases of patients with influenza who present with severe abnormal behavior are reported by physicians of all clinics and hospitals throughout Japan. Read More

Korean J Pediatr 2019 Feb 8. Epub 2019 Feb 8.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Coronary artery abnormalities (CAA) are the most important complication of Kawasaki disease (KD). Iron deficiency anemia (IDA) is prevalent micronutrient deficiencies and its association with KD remains unknown. We hypothesized the presence of IDA could be a predictor of CAA. Read More

Sci Rep 2019 Feb 11;9(1):1722. Epub 2019 Feb 11.

Department of Heart Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

Accurate evaluation of individual risk of intravenous immunoglobin (IVIG)-resistance is critical for adopting regimens for the first treatment and prevention of coronary artery lesions (CALs) in patients with Kawasaki disease (KD).

Methods: The KD patients hospitalized in Chongqing Children's Hospital, in west China, from October 2007 to December 2017 were retrospectively reviewed. Data were collected and compared between IVIG-resistant group and IVIG-responsive group. Read More

Indian J Pediatr 2019 Mar 11;86(3):216-217. Epub 2019 Feb 11.

Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Indian J Pediatr 2019 Feb 11. Epub 2019 Feb 11.

Department of Family Medicine, National University Health System, Singapore, Singapore.

Mitochondrion 2019 Feb 7. Epub 2019 Feb 7.

Department of Clinical Laboratory, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Japan.

Biomarkers and two clinical rating scales-the Japanese mitochondrial disease-rating scale (JMDRS) and Newcastle mitochondrial disease adult scale (NMDAS)-are clinically used when treating patients with mitochondrial disease. We explored the biomarker(s) and clinical rating scale(s) that are appropriate in preparing the protocol for a future clinical trial of sodium pyruvate (SP) therapy. A 48-week, prospective, single-centre, exploratory, clinical study enrolled 11 Japanese adult patients with genetically, biochemically, and clinically confirmed mitochondrial disease; they had intractable lactic acidosis and received SP (0. Read More

Br J Clin Pharmacol 2019 Feb 8. Epub 2019 Feb 8.

Division of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki, Japan.

Aims: This study aimed to identify population/regional differences in drug efficacy and the influencing factors among East Asians to be considered when planning multi-regional clinical trials (MRCTs) to facilitate rapid drug approval in Asians.

Methods: A retrospective analysis of efficacy (intergroup difference in endpoint between control and study drug treatment) among East Asian populations for three drug categories, antidiabetic, respiratory, and psychotropic agents, was conducted in collaboration with pharmaceutical companies using their MRCT data. Common endpoints by drug category were selected; background factors that commonly affected the endpoints among regions were analysed first; then, the population/regional differences were evaluated by the interaction term "region-by-treatment" using an analysis of covariance model after adjusting for background factors. Read More

Clin Exp Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

Background: No longitudinal study has investigated the impact of combination of kidney function (KF) and physical function (PF) on cognitive decline in these patients.

Methods: We conducted a 2-year prospective cohort study enrolling 131 patients ≥ 65 years with pre-dialysis chronic kidney disease (CKD). We assessed cognitive function with the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Read More

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan.

Carotid intraplaque hemorrhage (IPH) plays a critical role in the progression of carotid atherosclerotic disease. IPH was associated with high intensity signal (HIS) in the plaque on Maximum intensity projection (MIP) images from routine three dimensional magnetic resonance imaging (3D-TOF MRA). The aim of this study was to evaluate the relationships among HIS, new ipsilateral ischemic stroke and a progression rate in carotid plaques with moderate stenosis. Read More

Int J Rheum Dis 2019 Feb 6. Epub 2019 Feb 6.

Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

Aim: This study investigated the prognostic factors of cardiac death or cardiac failure using cardiac scintigraphy, echocardiography (UCG), and magnetic resonance imaging (MRI) in asymptomatic systemic sclerosis (SSc) patients.

Methods: We retrospectively evaluated SSc patients who had undergone cardiac scintigraphy using thallium ( Tl) and I-β-methyl-P-iodophenyl-pentadecanoic acid ( I-BMIPP), UCG, and cardiac MRI. We calculated the mismatch score in scintigraphy by subtracting the uptake of I-BMIPP from that of Tl. Read More

Psychogeriatrics 2019 Feb 6. Epub 2019 Feb 6.

Kawasaki Memorial Hospital, Kawasaki-city, Japan.

We herein report two patients with dementia with Lewy bodies (DLB) presenting characteristic symptoms suggestive of the behavioural variant of frontotemporal dementia (bvFTD). Patient 1 presented behavioural and personality changes from the onset, such as restlessness, compulsive behaviours, and stereotypical speech. A neuroimaging study showed preferential frontal involvement, and this patient fulfilled the diagnostic criteria for bvFTD. Read More

Genet Med 2019 Feb 6. Epub 2019 Feb 6.

Glyco Pharma Corporation, Oita, Japan.

The HTML version of this Article contained errors in Supplementary Figure S2 "Flowchart of the lyso-Gb3 screening and gene analysis in female patients", which have been detailed in the associated Correction. Read More

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Departments of Biomedical Sciences and Pediatrics, Divisions of Infectious Diseases and Immunology.

Kawasaki disease (KD), the leading cause of acquired cardiac disease among children, is often associated with myocarditis that may lead to long-term myocardial dysfunction and fibrosis. Although those myocardial changes develop during the acute phase, they may persist for decades and closely correlate with long-term myocardial sequelae. Using the Lactobacillus casei cell wall extract-induced (LCWE-induced) KD vasculitis murine model, we investigated long-term cardiovascular sequelae, such as myocardial dysfunction, fibrosis, and coronary microvascular lesions following adrenergic stimuli after established KD vasculitis. Read More

Int J Cardiol 2019 Jan 28. Epub 2019 Jan 28.

Departments of Pediatrics, Bioengineering and Institute for Computational and Mathematical Engineering, Stanford University, USA. Electronic address:

Background: Thrombosis is a major adverse outcome associated with coronary artery aneurysms (CAAs) resulting from Kawasaki disease (KD). Clinical guidelines recommend initiation of anticoagulation therapy with maximum CAA diameter (D) ≥8 mm or Z-score ≥ 10. Here, we investigate the role of aneurysm hemodynamics as a superior method for thrombotic risk stratification in KD patients. Read More

J Atheroscler Thromb 2019 Feb 7. Epub 2019 Feb 7.

Department of Insured Medical Care Management, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU).

Aims: Prediabetes and diabetes are associated with increased insulin resistance and decreased insulin production, dyslipidemia, and increased cardiovascular disease (CVD) risk. Our goals were to assess lipoprotein subfractions using novel assays in such subjects.

Methods: Fasting normal, prediabetic, and diabetic Taiwanese men and women (n=2,049) had their serum glucose, glycosylated hemoglobin, insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), HDL3-C, apolipoprotein E-HDL-C, direct low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C), LDL-TG, and remnant lipoprotein cholesterol (RLP-C) levels measured using novel assays. Read More

Clin Exp Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Rheumatology, Jiangxi Province Children's Hospital, No.122 Yangming Road, Nanchang, 330006, Jiangxi, China.

Arthritis is a major complication of Kawasaki disease (KD). The aims of this study were to define the frequency and the clinical characteristics of arthritis in KD in China and to analyze the relation between arthritis and coronary outcome in KD. We included 1420 KD patients followed at Jiangxi Children's Hospital from January 2014 to December 2017. Read More

IUBMB Life 2019 Feb 6. Epub 2019 Feb 6.

Department of Clinical Biological Resource Bank, Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Kawasaki disease (KD) is a systemic vasculitis syndrome that leads to coronary artery aneurysm (CAA). While echocardiography is the most important imaging modality for coronary artery assessment, a specific diagnostic biomarker complementary for CAA has not been reported. We aimed to analyze the profiles of exosomal miRNAs extracted from the serum of KD patients and controls to identify candidate biomarkers for CAA. Read More

Pediatr Res 2019 Jan 25. Epub 2019 Jan 25.

Cardiology Department, Children's Hospital of Soochow University, 215025, Suzhou, Jiangsu Province, China.

Background: We investigated a costimulatory molecule OX40-OX40L acting as an upstream regulator to regulate the nuclear factor of activated T cell (NFAT) in the acute phase of Kawasaki disease (KD).

Methods: One hundred and one samples were collected and divided into six groups: coronary artery lesion (KD-CAL) before intravenous immunoglobulin (IVIG), KD-CAL after IVIG, KD without CAL (KD-nCAL) before IVIG, KD-nCAL after IVIG, fever of unknown (Fou), and Healthy. In vitro OX40-stimulating and OX40L-inhibiting tests were conducted in Healthy and KD groups, respectively. Read More

EuroIntervention 2019 Feb 5. Epub 2019 Feb 5.

Koc University Hospital, Davutpaşa Street No: 4 Topkapi/Istanbul, 34087 Turkey.

Dis Markers 2019 3;2019:2849695. Epub 2019 Jan 3.

Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Background: Kawasaki disease (KD) is an acute vasculitis disease that commonly causes acquired heart disease in children. Coronary artery aneurysm (CAA) is a major complication of KD. However, the pathogenesis of KD remains unclear. Read More

An Pediatr (Barc) 2019 02;90(2):137-138

Sociedad Española de Cardiología Pediátrica y Cardiopatías Congénitas; Cardiología infantil, Servicio de Pediatría, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.

An Pediatr (Barc) 2019 Feb;90(2):135-136

Servicio de Pediatría. Cardiología infantil. Hospital Universitario Fundación Alcorcón.

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Paediatric Department, University Hospital Waterford, Waterford, Ireland.

A 8-year-old Irish ethnicity girl presented with 3 days of fever with right-sided neck swelling which was first thought as acute tonsillitis with right-sided lymphadenitis. She was started on intravenous antibiotics. At day 7 of illness, she was diagnosed to have Kawasaki disease with clinical and biochemical evidence. Read More

Front Nutr 2018 17;5:140. Epub 2019 Jan 17.

Department of Japanese-Traditional (Kampo) Medicine, Kanazawa University Hospital, Kanazawa, Japan.

This review aims to understand the clinical efficacy of (PG) for managing frailty-related disorders by reviewing meta-analyses, systematic reviews, and randomized clinical trial data. PG is widely used in traditional medicine, mainly in East Asia. It has traditionally been indicated for the collapse of qi or for abandoned conditions that manifest as shallow breathing, shortness of breath, cold limbs, profuse sweating, a low pulse rate, or weakness. Read More

Transl Psychiatry 2019 Jan 31;9(1):47. Epub 2019 Jan 31.

Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, 52246, USA.

Differential DNA methylation in the brain is associated with many psychiatric diseases, but access to brain tissues is essentially limited to postmortem samples. The use of surrogate tissues has become common in identifying methylation changes associated with psychiatric disease. In this study, we determined the extent to which peripheral tissues can be used as surrogates for DNA methylation in the brain. Read More

BMC Pediatr 2019 Jan 31;19(1):43. Epub 2019 Jan 31.

Department of Pediatric Rheumatology and Allergy, The First Hospital of Jilin University, Changchun, 130021, China.

Background: Kawasaki disease (KD) is an acute febrile vasculitis that primarily affects children. Previous studies have shown that both innate and adapt immune systems are involved in the immunopathogenesis of KD. The following study analyzes the distribution of the subsets of Circulating T follicular helper cells (cTfh cells) in KD patients with and without coronary artery lesions (CALs). Read More

Sci Rep 2019 Jan 30;9(1):977. Epub 2019 Jan 30.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.

Obesity-induced adipose-tissue dysfunction is a critical contributor to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). B cell-activating factor (BAFF) is an adipokine related to impaired insulin sensitivity, and the serum BAFF concentration is associated with NAFLD severity. In this study, we aimed to determine the direct in vivo role of BAFF in the development of insulin resistance, adipocyte dysfunction, and hepatic steatosis using BAFF mice fed a high-fat diet (HFD). Read More