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    1 OF 213
    Predictive Factors for Withdrawal from Peritoneal Dialysis: A Retrospective Cohort Study at Two Centers in Japan.
    Adv Perit Dial 2017 Jan;33(2017):68-73
    Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
    Peritoneal dialysis (PD) is recognized as an excellent method of dialysis because the therapy is gentle, continuous, and cost-effective. However, a large number of patients must unfortunately transfer from PD to hemodialysis because of peritonitis or fluid overload in the early phase after PD initiation. In the present study, we reviewed clinical indicators before PD initiation to try to identify predictive factors for early withdrawal from PD. Read More
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    Anti-inflammatory effect of statin in coronary aneurysms late after Kawasaki disease.
    J Nucl Cardiol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
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    Associations of chronic urticaria with atopic and autoimmune comorbidities: a nationwide population-based study.
    Int J Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Health Services Administration, China Medical University, Taichung, Taiwan.
    Background: Most cases of chronic urticaria (CU) are idiopathic. Circumstantial evidence suggests that some CU cases have an autoimmune pathogenesis. Previous research indicates that a substantial percentage of patients with CU have an atopic background. Read More
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    Relationship between mean platelet volume-to-lymphocyte ratio and coronary artery abnormalities in Kawasaki disease.
    Cardiol Young 2018 Apr 16:1-5. Epub 2018 Apr 16.
    1Department of Pediatrics,University of Mersin Faculty of Medicine,Mersin,Turkey.
    Objectives: Recently, mean platelet volume-to-lymphocyte ratio has emerged as a novel parameter of inflammation. No study has investigated the role of mean platelet volume-to-lymphocyte ratio in children with Kawasaki disease. We aimed to evaluate the relationship between mean platelet volume-to-lymphocyte ratio and coronary artery abnormalities in Kawasaki disease. Read More
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    Radiofrequency catheter ablation for ventricular tachycardia in ischaemic cardiomyopathy due to Kawasaki disease.
    Cardiol Young 2018 Apr 16:1-4. Epub 2018 Apr 16.
    Department of Cardiology,Gifu University Graduate School of Medicine,Gifu,Japan.
    In some patients with Kawasaki disease, a prior myocardial infarction causes ventricular tachycardia in the chronic post-myocardial infarction phase. We report the case of a 41-year-old man with symptomatic and haemodynamically unstable ventricular tachycardia in whom substrate ablation was performed for the ventricular tachycardia before insertion of an implantable cardioverter-defibrillator. Read More
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    Quantitative assessment of the association between IL-10 -592 A/C polymorphism and Kawasaki disease risk in Chinese population: evidence from a meta-analysis.
    Cardiol Young 2018 Apr 16:1-5. Epub 2018 Apr 16.
    2Department of Clinical Laboratory,First Affiliated Hospital of Soochow University,Suzhou,People's Republic of China.
    Background: IL-10, as a proinflammatory and anti-inflammatory cytokine, has been thought to have an important role in the development of Kawasaki disease. Variation in the IL-10 gene might lead to altered protein production, which may result in Kawasaki disease. Several studies have been performed to investigate the IL-10 -592 A/C polymorphism and Kawasaki disease risk. Read More
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    Validation by Cardiac Catheterization of Noninvasive Estimation of Time Constant of Left Ventricular Pressure Decline as an Index of Relaxation by Speckle Tracking Echocardiography.
    Am J Cardiol 2018 Mar 14. Epub 2018 Mar 14.
    Gifu University Graduate School of Medicine, Gifu, Japan.
    There has been no established echocardiographic parameter to accurately assess left ventricular (LV) relaxation. Impaired LV relaxation assessed by the time constant of LV pressure decline (Tau) is one of the major components of diastolic dysfunction. We sought to noninvasively estimate Tau (eTau) by speckle tracking echocardiography (STE) and to validate the eTau against Tau by catheterization. Read More
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    [Cardiac manifestations in the acute phase of Kawasaki disease in a third level children's hospital in Mexico City].
    Arch Cardiol Mex 2018 Apr 9. Epub 2018 Apr 9.
    Servicio de Inmunología, Instituto Nacional de Pediatría, SSA, Ciudad de México, México.
    Objectives: To describe the cardiac manifestations in the acute phase of patients with Kawasaki disease treated in a third level Children's hospital in Mexico City, Mexico.

    Methods: A cross-sectional study was conducted in patients with a diagnosis of Kawasaki disease treated in this hospital from August 1995 to December 2016. Information included patient demographics, clinical features, treatment used, electrocardiographic findings, extra-coronary echocardiographic findings, and the development of coronary artery aneurysms in the acute phase of the disease. Read More
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    Predictive performance of dual modality of computed tomography angiography and intravascular ultrasound for no-reflow phenomenon after percutaneous coronary stenting in stable coronary artery disease.
    Heart Vessels 2018 Apr 11. Epub 2018 Apr 11.
    Division of Cardiology, Tokai University School of Medicine, Isehara, Japan.
    Attenuated plaque on intravascular ultrasound (IVUS) and low attenuation plaque on computed tomography angiography (CTA) are associated with no-reflow phenomenon during percutaneous coronary intervention (PCI). However, evaluation by a single modality has been unable to satisfactorily predict this phenomenon. We investigated whether the combination of IVUS and CTA findings can ameliorate the predictive potential for no-reflow phenomenon after stent implantation during PCI in stable coronary artery disease (CAD). Read More
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    Thrombospondin-2 predicts response to treatment with intravenous immunoglobulin in children with Kawasaki disease.
    BMJ Paediatr Open 2018 3;2(1):e000190. Epub 2018 Jan 3.
    Clinical Center Laboratory, Capital Institute of Pediatrics, Beijing, China.
    Objective: To investigate the predictive value of thrombospondin-2 (TSP-2) in assessing the response to intravenous immunoglobulin (IVIG) in children with acute Kawasaki disease (KD).

    Methods: This was a cohort study with controls. 71 children with KD were recruited as the case group, including IVIG non-responder (n=17) and IVIG responder (n=54), and healthy children (n=27) and febrile children (n=30) were used as control groups. Read More
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    Sox17 is Essential for Proper Formation of the Marginal Zone of Extraembryonic Endoderm Adjacent to a Developing Mouse Placental Disk.
    Biol Reprod 2018 Apr 4. Epub 2018 Apr 4.
    Department of Veterinary Anatomy, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
    In mouse conceptus, two yolk-sac membranes, the parietal endoderm (PE) and visceral endoderm (VE), are involved in protecting and nourishing early-somite-stage embryos prior to the establishment of placental circulation. Both PE and VE membranes are tightly anchored to the marginal edge of the developing placental disk, in which the extraembryonic endoderm (marginal zone endoderm: ME) shows the typical flat epithelial morphology intermediate between those of PE and VE in vivo. However, the molecular characteristics and functions of the ME in mouse placentation remain unclear. Read More
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    Wisteria floribunda agglutinin-positive Mac-2 binding protein and type 4 collagen 7S are useful markers for the diagnosis of significant fibrosis in patients with nonalcoholic fatty liver disease.
    J Gastroenterol Hepatol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
    Background And Aim: The fibrosis stage of liver is associated with the long-term outcomes in patients with nonalcoholic fatty liver disease (NAFLD). However significant fibrosis, defined as fibrosis stage 2-4, is associated with an elevated risk of progression to severe liver disease, there have been scant reports about diagnosing significant fibrosis. We compare the non-invasive method, and aimed to identify appropriate liver fibrosis markers for detecting significant fibrosis in NAFLD patients. Read More
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    Long Term Outcomes of Left Atrial Reservoir Function in Children with a History of Kawasaki Disease.
    J Cardiovasc Ultrasound 2018 Mar 28;26(1):26-32. Epub 2018 Mar 28.
    Department of Diagnostic Laboratory Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
    Background: Decreased left atrial (LA) reservoir function is reported to be associated with elevated left ventricular (LV) end diastolic pressure and LV diastolic dysfunction. Echocardiographic parameters that reflect LA reservoir function include LA total emptying fraction [(maximum LA volume - minimum LA volume) / maximum LA volume], peak LA longitudinal strain (PLALS) at systole, and LA stiffness index (E/E´/PLALS). We aimed to investigate the long-term outcomes of LV diastolic function in children with a history of Kawasaki disease (KD) (KDHx group) by assessing LA reservoir function. Read More
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    Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study.
    BMC Nephrol 2018 Apr 6;19(1):82. Epub 2018 Apr 6.
    Department of Pediatric Nephrology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
    Background: C1q nephropathy (C1qN) was first described as glomerular disease characterized by predominant meangial C1q deposits in patients with proteinuria and no evidence of systemic lupus erythematosus. Several studies, however, revealed the clinical heterogeneity of C1qN, showing some cases with normal urinalysis. To confirm the existence of cases with predominant mesangial C1q deposits and negative or mild proteinuria and/or hematuria, we investigated renal graft biopsy specimens showing negative to mild proteinuria (less than or equal to 1+ by dip stick test) and/or hematuria. Read More
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    Laboratory Markers in Incomplete Kawasaki Disease according to Coronary Artery Outcome.
    Korean Circ J 2018 Apr;48(4):287-295
    Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea.
    Background And Objectives: We defined laboratory marker profiles typical of incomplete Kawasaki disease (iKD) during illness, especially with respect to the presence of a coronary artery abnormality such as coronary artery dilation or aneurysm.

    Methods: This retrospective study examined the clinical and laboratory markers of patients with iKD over time, along with those of patients with complete KD (cKD) and febrile controls.

    Results: Of 795 patients, 178 had iKD, 504 had cKD and 113 were febrile controls. Read More
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    Clinical significance of serum soluble TNF receptor II level and soluble TNF receptor II/I ratio as indicators of coronary artery lesion development in Kawasaki disease.
    Cytokine 2018 Apr 3;108:168-172. Epub 2018 Apr 3.
    Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
    To investigate the clinical significance of serum soluble tumor necrosis factor receptor (sTNFR) II level and sTNFR II/I ratio as indicators of the development of coronary artery lesions (CALs) in Kawasaki disease (KD), we measured levels of serum sTNFR I and II, interleukin (IL)-6, IL-18, and neopterin in 63 patients with KD, including nine patients with CALs and 20 healthy controls. At the time of diagnosis of KD before intravenous immunoglobulin (IVIG) treatment, serum sTNFR I and II levels were found to be significantly higher in non-responders to IVIG treatment than in responders. On the contrary, serum sTNFR II levels and sTNFR II/I ratio were significantly higher in patients with KD having CALs than in those without CALs. Read More
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    Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease.
    Clin Pharmacokinet 2018 Apr 5. Epub 2018 Apr 5.
    Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
    Background: Infliximab, a monoclonal antibody directed against tumor necrosis factor-α, is being evaluated as adjunctive therapy to intravenous immunoglobulin (IVIG) for treatment of young children with acute Kawasaki disease (KD).

    Objective: The aim of this study was to develop a population pharmacokinetic (PopPK) model for infliximab in children with KD, and to evaluate the impact of covariates on infliximab disposition. Specifically, we wanted to investigate the effect of body weight and IVIG administration on PK parameters. Read More
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    Coronary artery bypass surgery in patients with chronic brain hypoperfusion.
    J Cardiovasc Surg (Torino) 2018 Apr 3. Epub 2018 Apr 3.
    Nippon Medical School Hospital, Tokyo, Japan.
    Background: Cerebrovascular disease (CVD) is a risk factor of stroke and cerebral hypoperfusion is one of the underlying mechanisms. We hypothesized that coronary artery bypass grafting (CABG) can be performed at an acceptable risk for such patients without concomitant surgery for CVD.

    Methods: Carotid echo was carried out for 538 consecutive patients undergoing isolated CABG between 2005 and 2016. Read More
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    Unfolded protein response is activated in Krabbe disease in a manner dependent on the mutation type.
    J Hum Genet 2018 Apr 3. Epub 2018 Apr 3.
    Department of Health Science, Child Healthcare and Genetic Science, Osaka University Graduate School of Medicine, Osaka, Japan.
    Krabbe disease, one of the autosomal-recessive lysosomal storage disorders (LSDs), is caused by a deficiency of galactocerebrosidase (GALC) activity, resulting in the intracellular accumulation of psychosine, which is cytotoxic for neuronal cells. Genetically pathogenic mutations result in conformational changes in GALC and disrupt the lysosmal trafficking of cargos, which subsequently accumulate in the endoplasmic reticulum (ER). Recently, ER stress together with the activation of the unfolded protein response (UPR) has been suggested to play a key role in the pathogenesis of LSDs. Read More
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    Association between the retinal vascular network with Singapore "I" Vessel Assessment (SIVA) software, cardiovascular history and risk factors in the elderly: The Montrachet study, population-based study.
    PLoS One 2018 3;13(4):e0194694. Epub 2018 Apr 3.
    Department of Ophthalmology, University Hospital, Dijon, France.
    Purpose: To identify patterns summarizing the retinal vascular network in the elderly and to investigate the relationship of these vascular patterns with cardiovascular history.

    Methods: We conducted a population-based study, the Montrachet study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases), in participants older than 75 years. The history of cardiovascular disease and a score-based estimation of their 10-year risk of cardiovascular mortality (Heart SCORE) were collected. Read More
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    Proteomics study of serum exosomes in Kawasaki disease patients with coronary artery aneurysms.
    Cardiol J 2018 Apr 3. Epub 2018 Apr 3.
    Guangzhou Women and Children' s Medical Center, China.
    Background: To study the protein profile of the serum exosomes of patients with coronary artery aneurysms (CAA) caused by Kawasaki disease (KD).

    Methods: Two-dimensional electrophoresis (2-DE) was used to identify proteins from the exosomes of serum obtained from children with CAA caused by KD, as well as healthy controls. Differentially expressed proteins were identified using matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry (MALDI-TOF/TOF MS) analysis. Read More
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    Preliminary human application of optical coherence tomography for quantification and localization of primordial follicles aimed at effective ovarian tissue transplantation.
    J Assist Reprod Genet 2018 Apr 2. Epub 2018 Apr 2.
    Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki City, Kanagawa, 216-8511, Japan.
    Purpose: The purpose of this study was to evaluate the possible clinical application of optical coherence tomography for assessing ovarian reserve in individual specimens of human ovarian tissue for fertility preservation.

    Methods: Ovarian tissue examination by optical coherence tomography was performed before ovarian tissue cryopreservation. Three of the four subjects had hematological disease or cancer, and they faced a threat to their fertility due to impending chemotherapy. Read More
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    Kawasaki disease: multiple giant coronary aneurysms intervention and pacemaker implantation due to complete heart block-a case report.
    J Thorac Dis 2018 Feb;10(2):E108-E112
    Department of Cardiovascular Disease, General Hospital of PLA Army, Beijing 100700, China.
    Early intravenous immunoglobulin (IVIG) is the standard treatment for Kawasaki disease (KD) to reduce the incidence of coronary aneurysms. Patients with atypical presentation or who live in a rural area are less likely to receive treatment in the early stage of presentation and are more likely to develop severe complications. There is little consensus on how to treat coronary aneurysms effectively in the acute or subacute stage especially when giant aneurysms develop that compromise cardiac function. Read More
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    GNAS-mutated carcinoma arising from gastric foveolar metaplasia in the duodenum after 9 years of observation.
    Clin J Gastroenterol 2018 Mar 31. Epub 2018 Mar 31.
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan.
    This case involved an 80-year-old man. Screening with esophagogastroduodenoscopy (EGD) in 2004 revealed Brunner's gland hyperplasia (BGH), 5 mm in size, in the duodenal bulb. The size of the lesion increased and its shape has changed since then, as detected in subsequent EGDs. Read More
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    A critical appraisal of the role of intracellular Ca-signaling pathways in Kawasaki disease.
    Cell Calcium 2018 May 3;71:95-103. Epub 2018 Feb 3.
    KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, B-3000 Leuven, Belgium. Electronic address:
    Kawasaki disease is a multi-systemic vasculitis that generally occurs in children and that can lead to coronary artery lesions. Recent studies showed that Kawasaki disease has an important genetic component. In this review, we discuss the single-nucleotide polymorphisms in the genes encoding proteins with a role in intracellular Ca signaling: inositol 1,4,5-trisphosphate 3-kinase C, caspase-3, the store-operated Ca-entry channel ORAI1, the type-3 inositol 1,4,5-trisphosphate receptor, the Na/Ca exchanger 1, and phospholipase Cß4 and Cß1. Read More
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    Awareness of atrial fibrillation in Japan: A large-scale, nationwide Internet survey of 50 000 Japanese adults.
    Geriatr Gerontol Int 2018 Mar 30. Epub 2018 Mar 30.
    Department of Neurology, St. Marianna University School of Medicine, Kawasaki, Japan.
    Aim: Atrial fibrillation (AF) is the most common underlying cause of cardiogenic cerebral embolism. To prevent cardiogenic cerebral embolism, it is important to determine the level of awareness of AF in Japan.

    Methods: We used survey monitor attribute data to sample 172 824 Japanese adults aged ≥50 years from all 47 Japanese prefectures. Read More
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    Serum Levels of Syndecan-1 in Patients with Kawasaki Disease.
    Pediatr Infect Dis J 2018 Mar 29. Epub 2018 Mar 29.
    Background: Kawasaki disease (KD) is an acute systemic vasculitis with coronary artery lesions (CALs) being the major concern. Syndecan-1 (SDC-1) is a major core protein expressed on the glycocalyx of endothelial cells. Shed SDC-1 in serum is regarded as a biomarker for endothelial activation or damage. Read More
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    The risk of hospitalization for respiratory tract infection (RTI) in children who are treated with high-dose IVIG in Kawasaki Disease: a nationwide population-based matched cohort study.
    PeerJ 2018 22;6:e4539. Epub 2018 Mar 22.
    Department of General Surgery, E-Da Hospital, Kaohsiung, Taiwan.
    Background: Kawasaki disease (KD) is an immune-mediated systemic vasculitis, and infection plays an important role in the pathophysiology of KD. The susceptibility to infectious disease in patients with KD remains largely unclear. This study aimed to investigate the risk of respiratory tract infection (RTI)-related hospitalizations in children with KD. Read More
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    Exercise habituation is effective for improvement of periodontal disease status: a prospective intervention study.
    Ther Clin Risk Manag 2018 20;14:565-574. Epub 2018 Mar 20.
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
    Background And Purpose: Periodontal disease is closely related to lifestyle-related diseases and obesity. It is widely known that moderate exercise habits lead to improvement in lifestyle-related diseases and obesity. However, little research has been undertaken into how exercise habits affect periodontal disease. Read More
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    Giant coronary artery aneurysms in a 12-week-old infant with incomplete Kawasaki disease.
    BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.
    School of Clinical Sciences, University of Bristol, Bristol, UK.
    Kawasaki disease (KD) is an acute inflammatory vasculitis that occurs worldwide and disproportionately affects male children, most commonly between the ages of 6 months and 5 years. KD can present with only a few features and thus be difficult to diagnose, particularly in the youngest and oldest patients. We describe a 12-week-old Caucasian female infant who presented with rash and fever but no other features of KD, who developed giant coronary artery aneurysms. Read More
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    Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models.
    Dis Model Mech 2018 Feb 26;11(2). Epub 2018 Feb 26.
    Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan
    Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) refer to a group of heterogeneous cancers of neuroendocrine cell phenotype that mainly fall into one of two subtypes: gastroenteropancreatic neuroendocrine tumors (GEP-NETs; well differentiated) or gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs; poorly differentiated). Although originally defined as orphan cancers, their steadily increasing incidence highlights the need to better understand their etiology. Accumulating epidemiological and clinical data have shed light on the pathological characteristics of these diseases. Read More
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    Treatment outcome of children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group (TCCSG) Study L04-16.
    Int J Hematol 2018 Mar 27. Epub 2018 Mar 27.
    Department of Pediatrics, Toho University, 6-11-1 Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan.
    The survival rate of children with acute lymphoblastic leukemia (ALL) has increased to approximately 90% after substantial progress in risk-oriented treatment strategies. Between 2005 and 2013, the Tokyo Children's Cancer Study Group (TCCSG) conducted a risk-oriented, non-randomized study, L04-16. The principal aim of this study was to assemble background characteristics and treatment outcomes, and gather genetic information on leukemic cells under central diagnosis. Read More
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    Epigenetic modification of as a novel biomarker for the prognosis of early stage head and neck cancer.
    J Cancer 2018 28;9(6):941-949. Epub 2018 Feb 28.
    Department of Otolaryngology/Head and Neck Surgery, Jichi Medical University, Tochigi, Japan.
    This study examined ( methylation profiles in head and neck squamous-cell carcinoma (HNSCC) patients at diagnosis and follow-up, and evaluated their prognostic significance and value as a biomarker. expression was examined in a panel of cell lines by quantitative reverse transcription PCR (qRT-PCR). Promoter methylation was determined by quantitative methylation-specific polymerase chain reaction (qMSP) and was compared to the clinical characteristics of 205 samples. Read More
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    Suppressed plasmablast responses in febrile infants, including children with Kawasaki disease.
    PLoS One 2018 26;13(3):e0193539. Epub 2018 Mar 26.
    Department of Pediatrics, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, United States of America.
    Background: Kawasaki disease (KD), the leading cause of acquired heart disease in children, primarily affects infants and toddlers. Investigations on immune responses during KD are hampered by a limited understanding of normal immune responses in these ages. It's well known that Infants have poorer vaccine responses and difficulty with maintaining prolonged serum immunity, but there are few studies on human infants detailing immune deficiencies. Read More
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    Nigerian Children with Acquired Heart Disease: The Experience in Lagos.
    J Tehran Heart Cent 2017 Oct;12(4):160-166
    Department of Paediatrics and Child Health, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria.
    Most of the recent reports on acquired heart diseases (AHDs) among Nigerian children are either retrospective or cover a short period of time with fewer subjects. The last report on AHDs among children in Lagos was about a decade ago; it was, however, not specific to children with AHDs but was part of a report on structural heart diseases among children in Lagos. The present study was carried out to document the prevalence and profile of different AHDs in children and to compare the findings with those previously reported. Read More
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    Significance of stereotactic body radiotherapy in older patients with early stage non-small cell lung cancer.
    J Geriatr Oncol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Radiation Oncology, Kawasaki Saiwai Hospital, Kawasaki, Kanagawa, Japan. Electronic address:
    Objectives: Our aim was to investigate long-term treatment outcomes in older patients with early stage non-small cell lung cancer (NSCLC) and the presence or absence of therapeutic benefits, using the G8 screening tool.

    Methods: We retrospectively studied 43 older patients (median age 78 years, range 65-89 years) with stage I lung tumors (T1 and T2 tumors in 34 and 9 patients, respectively), who underwent stereotactic body radiotherapy (SBRT). This study assessed outcomes in a cohort of patients who received geriatric assessments, performed between 2004 and 2011, before the start of their SBRT regimen. Read More
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    Disease burden and challenges of chronic kidney disease in North and East Asia.
    Kidney Int 2018 Mar 21. Epub 2018 Mar 21.
    Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, National Health and Family Planning Commission of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China. Electronic address:
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    Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91 , phagocyte flavocytochrome b large subunit.
    Microbiol Immunol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Biochemistry, Kawasaki Medical School, 577 Matsushima Kurashiki, Okayama 701-0192, Japan.
    Human phagocyte flavocytochrome b (Cyt b), the catalytic center of NADPH oxidase, consists of a heavily glycosylated large subunit (gp91 , Nox2) and a small subunit (p22 ). Cyt b is a membrane-spanning complex enzyme. Chronic granulomatous disease (CGD) is predominantly caused by a mutation in the CYBB gene encoding gp91 on the X-chromosome. Read More
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    Predictors of Intravenous Immunoglobulin Non-Response and Racial Disparities in Kawasaki Disease.
    Pediatr Infect Dis J 2018 Mar 19. Epub 2018 Mar 19.
    Departments of Internal Medicine and Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. Greater Lawrence Family Health Center, Lawrence, MA, USA. Tennessee Department of Health, Nashville, TN, USA. Department of Pediatrics, Division of Pediatric Infectious Disease, Vanderbilt University Medical Center, Nashville, TN, USA. Department of Biostatistics, Vanderbilt University, Nashville, TN, USA.
    Background: Kawasaki disease (KD) is the most common cause of acquired heart disease in American children. IVIG non-response is a known risk factor for cardiac sequelae. Previously reported risk factors for non-response include age, male sex, and laboratory abnormalities. Read More
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    Gastric Emptying of Elemental Liquid Diets Versus Semisolid Diets in Bedridden Gastrostomy-fed Patients.
    J Clin Gastroenterol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Surgery, Showa Inan General Hospital, Komagane.
    Background: Aspiration is a common problem in bedridden gastrostomy-fed patients. We compared gastric emptying of an elemental liquid diet and a commercial semisolid diet in bedridden gastrostomy-fed patients.

    Methods: Study 1: from January 2013 to December 2016, consecutive bedridden patients receiving percutaneous endoscopic gastrostomy (PEG) semisolid feeding hospitalized due to aspiration pneumonia were switched to elemental liquid diet feedings. Read More
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    Melanoma and Immune Checkpoint Inhibitors.
    Curr Oncol Rep 2018 Mar 23;20(3):29. Epub 2018 Mar 23.
    Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka, 812-8582, Japan.
    Purpose Of Review: Prognosis of patients with advanced melanoma is dismal with a median overall survival of about 8 months and 5-year overall survival from a diagnosis of metastatic disease of roughly 10%. However, immune checkpoint inhibitors have brought indispensable benefits to melanoma patients. Here we will review the recent clinical efficacy and adverse events of immune checkpoint inhibitors for melanoma patients. Read More
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    Management of sequelae of Kawasaki disease in adults.
    Glob Cardiol Sci Pract 2017 Oct 31;2017(3):e201731. Epub 2017 Oct 31.
    Dept of Pediatrics, University of California San Diego, and Rady Children's Hospital, San Diego, CA, USA.
    A growing population of young adults is presenting to cardiologists with late manifestations of Kawasaki disease (KD) that include cardiomyopathy, ischemia, and infarction. The management of these conditions differs in important ways from atherosclerotic heart disease, and yet there is little awareness in the adult cardiology community regarding the special challenges posed by the cardiovascular sequelae of KD. Observations were made on a population of 140 adult KD patients enrolled in the San Diego Adult KD Collaborative Study. Read More
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