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J Mol Cell Cardiol 2020 Jul 4. Epub 2020 Jul 4.

Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.

Background: Kawasaki Disease (KD) is an acute vasculitis of unknown etiology in children that can lead to coronary artery lesions (CAL) in 25% of untreated patients. There is currently no diagnostic test for KD, and the clinical presentation is often difficult to differentiate from other febrile childhood illnesses. Circulating microRNAs (miRNAs) are small noncoding RNA molecules that control gene expression by inducing transcript degradation or by blocking translation. Read More

Am J Emerg Med 2020 Jun 25. Epub 2020 Jun 25.

Division of Rheumatology, Maimonides Medical Center, Brooklyn, NY, United States of America. Electronic address:

Recent reports have described a secondary Multisystem Inflammatory Syndrome in Children (MIS-C) after a prior COVID-19 infection that often has features of Kawasaki disease (KD). Here, we report the case of a 36-year-old woman who presented to the emergency department hypotensive and tachycardic after 1 week of fevers, abdominal pain, vomiting and diarrhea, and was found to have the classic phenotype of complete Kawasaki's Disease including nonexudative conjunctivitis, cracked lips, edema of the hands and feet, palmar erythema, a diffuse maculopapular rash, and cervical lymphadenopathy. Initial laboratory studies were significant for hyponatremia, elevated liver function tests including direct hyperbilirubinemia, and leukocytosis with neutrophilia. Read More

Children (Basel) 2020 Jul 1;7(7). Epub 2020 Jul 1.

Department of Pediatrics, Division of Neonatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. Some features of MIS-C resemble Kawasaki Disease, toxic shock syndrome, and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. Read More

EBioMedicine 2020 Jul 3;57:102861. Epub 2020 Jul 3.

Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3695, Japan. Electronic address:

Background: The NEJ026 Phase 3 study demonstrated that erlotinib and bevacizumab (BE)-treated NSCLC patients with EGFR mutations had significantly better progression-free survival (PFS) than those treated with erlotinib alone (E). This study included a prospective analysis of the relationship between the mutational status of EGFR in plasma circulating tumor DNA (ctDNA) and the efficacy of TKI monotherapy or combination therapy. We describe these results herein. Read More

J Vestib Res 2020 Jun 27. Epub 2020 Jun 27.

Yoshimura ENT Clinic, Fujisawa, Japan.

Background: There are only a few reports concerning cervical vestibular evoked myogenic potential (cVEMP) using chirp sound, and clinical indications/advantages of it are still unclear.

Objective: To compare cVEMP using CE-chirp LS® with cVEMP using 500 Hz and 1000 Hz tone bursts (TB) and to investigate clinical indications/advantages of CE-chirp LS® for recording cVEMP.

Methods: Sixteen patients with vestibular disorders (2men and 14 women) (18∼62, mean 42. Read More

Lancet Child Adolesc Health 2020 Jul 2. Epub 2020 Jul 2.

Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore. Electronic address:

Lancet Child Adolesc Health 2020 Jul 2. Epub 2020 Jul 2.

Department of General Paediatrics, Paediatric Internal Medicine, Rheumatology and Infectious Diseases, National Referee Centre for Rheumatic, Autoimmune and Systemic Diseases in Children, Robert Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Université de Paris, UFR de Médecine Paris Nord, Paris, France; Center for Research on Inflammation, INSERM, UMR1149, Paris, France; Biology and Genetics of Bacterial Cell Wall Unit, Pasteur Institute, Paris, France. Electronic address:

Background: Kawasaki disease is an acute febrile systemic childhood vasculitis, which is suspected to be triggered by respiratory viral infections. We aimed to examine whether the ongoing COVID-19 epidemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with an increase in the incidence of Kawasaki disease.

Methods: We did a quasi-experimental interrupted time series analysis over the past 15 years in a tertiary paediatric centre in the Paris region, a French epicentre of the COVID-19 outbreak. Read More

Can J Cardiol 2020 Jul 1. Epub 2020 Jul 1.

Division of Cardiology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Background: The substantial risk of thrombosis in large coronary artery aneurysms (CAAs) (maximum z-score ≥ 10) after Kawasaki disease (KD) mandates effective thromboprophylaxis. We sought to determine the effectiveness of anticoagulation (low-molecular-weight heparin [LMWH] or warfarin) for thromboprophylaxis in large CAAs.

Methods: Data from 383 patients enrolled in the International KD Registry (IKDR) were used. Read More

J Pediatr 2020 Jun 30. Epub 2020 Jun 30.

Department of Pediatrics, Rady Children's Hospital, University of California San Diego, San Diego, CA USA.

Pediatr Infect Dis J 2020 Jun 30. Epub 2020 Jun 30.

From the Department of Pediatric Cardiology and Pediatric Intensive Care, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

Kawasaki disease (KD) patients' resistance to treatment with intravenous immunoglobulins (IVIG) places them at high risk for an unfavorable progression of the disease. In these patients, there has been little evidence that alternative treatments are effective. Nevertheless, biologicals such as an interleukin-1-receptor blocker and tumor-necrosis-factor-α inhibitors increasingly have been used. Read More

Sci Rep 2020 Jul 2;10(1):10881. Epub 2020 Jul 2.

Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, 216-8511, Japan.

It is unclear how epidermal growth factor receptor EGFR major driver mutations (L858R or Ex19del) affect downstream molecular networks and pathways. This study aimed to provide information on the influences of these mutations. The study assessed 36 protein expression profiles of lung adenocarcinoma (Ex19del, nine; L858R, nine; no Ex19del/L858R, 18). Read More

MMWR Morb Mortal Wkly Rep 2020 Jul 3;69(26):847-849. Epub 2020 Jul 3.

On March 26, 2020, Colorado instituted stay-at-home orders to reduce community transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). To inform public health messaging and measures that could be used after reopening, persons with laboratory-confirmed COVID-19 during March 9-26 from nine Colorado counties comprising approximately 80% of the state's population (Adams, Arapahoe, Boulder, Denver, Douglas, El Paso, Jefferson, Larimer, and Weld) were asked about possible exposures to SARS-CoV-2 before implementation of stay-at-home orders. Among 1,738 persons meeting the inclusion criteria in the Colorado Electronic Disease Surveillance System, 600 were randomly selected and interviewed using a standardized questionnaire by telephone. Read More

J Intensive Care 2020 30;8:44. Epub 2020 Jun 30.

Division of Acute and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Diagnosing sepsis remains difficult because it is not a single disease but a syndrome with various pathogen- and host factor-associated symptoms. Sepsis-3 was established to improve risk stratification among patients with infection based on organ failures, but it has been still controversial compared with previous definitions. Therefore, we aimed to describe characteristics of patients who met sepsis-2 (severe sepsis) and sepsis-3 definitions. Read More

Front Physiol 2020 16;11:579. Epub 2020 Jun 16.

Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.

Wooden breast syndrome (WB) constitutes an emerging myopathy in the pectoralis major muscle (PM) of broiler chickens, characterized by myofiber hypertrophy and degeneration along with severe fibrosis. WB pathogenesis has been considered to involve hypoxia induced by rapid growth of the PM. In this study, we focused on mitochondrial morphology and dynamics in the myofibers, as these organelles are sensitive to damage by hypoxia, and examined the effects on WB pathogenesis. Read More

J Nippon Med Sch 2020 Jun 30. Epub 2020 Jun 30.

Department of Pediatrics, Nippon Medical School Hospital.

Kawasaki disease is a systemic vasculitis of unknown etiology and is known to be associated with various digestive disorders, though only a few cases of intussusception associated with Kawasaki disease have been reported. The case of a 3-year-old boy with intussusception followed by Kawasaki disease is reported. The patient was admitted to our hospital due to severe abdominal pain. Read More

Circ J 2020 Jul 2. Epub 2020 Jul 2.

Emeritus Professor of Pediatrics and Child Health, Kurume University.

RMD Open 2020 06;6(2)

Department of Clinical Sciences and Community Health, University of Milan, and ASST G. Pini, Milan, Italy.

A few weeks after the peak of the global 2019 novel coronavirus disease pandemic, cases of shock, multisystem inflammation and severe myocarditis have occurred in children and adolescents, generating some concerns and above all many questions. An almost immediate association raised with shock syndrome related to Kawasaki disease (KD). However, in light of bo/th experience and literature have taught us about severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection, and what already known on the epidemiology of KD, we suggest here the hypothesis of a new 'post-viral' systemic inflammatory disease related to excessive adaptive immune response rather than a form of KD caused by SARS-COV-2. Read More

Sci Total Environ 2020 Jun 23;741:140469. Epub 2020 Jun 23.

Department of Pediatrics, National Hospital Organization Beppu Medical Center, 1473 Oaza-Uchikamado, Beppu, Oita 874-0011, Japan. Electronic address:

Environmental factors have been suspected to have effects on the development of Kawasaki disease. However, the associations have been conflicting. The aim of this study was to investigate the effects of air pollution, weather conditions, and epidemic infections on the risks for Kawasaki disease in Japan. Read More

Hepatol Res 2020 Jul 1. Epub 2020 Jul 1.

Institute for Gastrointestinal and Liver Diseases, Shin-yurigaoka General Hospital, Kawasaki, Japan.

Aim: Lusutrombopag is approved for thrombocytopenia in chronic liver disease patients planned to undergo invasive procedures. In previous clinical studies, lusutrombopag treatment was stopped in patients with an increase in platelet count (PC) of ≥20×10 /L from baseline and whose PC was ≥50×10 /L (discontinuation criteria). We assessed the influences of platelet monitoring during lusutrombopag administration in lusutrombopag naïve patients. Read More

Dermatopathology (Basel) 2020 Jun 30;7(1):3-16. Epub 2020 Jun 30.

Department of Clinical Pharmacology and Toxicology, University of Geneva, 1205 Geneva, Switzerland.

In recent weeks, several reports have emerged of skin lesions with different clinical presentations in COVID-19 cases. All dermatologists should be aware of these cutaneous lesions, which may be early clinical symptoms of infection. We reviewed the literature on cutaneous manifestations in the PubMed database from December 2019 and June 2020. Read More

Int J Hematol 2020 Jun 30. Epub 2020 Jun 30.

Osaka University, Osaka, Japan.

Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan. Read More

Int J Nephrol Renovasc Dis 2020 18;13:157-162. Epub 2020 Jun 18.

Department of Nephrology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Low-density lipoprotein apheresis (LDL-A) has been developed as a therapy for familial hypercholesterolemia, but LDL-A has also been used as a general treatment for drug-resistant nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS). The patients with NS due to minimal change disease (MCD) are often difficult to control effective circulating plasma volume, causes acute kidney injury (AKI), and when diuretics are not effective and the respiratory condition of patients worsens, patients require acute renal replacement therapy (ARRT). The effectiveness of LDL-A is not only reduction of serum low-density lipoprotein but also various other benefits. Read More

Crit Care 2020 Jun 30;24(1):387. Epub 2020 Jun 30.

Division of Acute and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between the vital signs and mortality are different in elderly and non-elderly patients with sepsis.

Methods: This was a retrospective observational study. Read More

Cardiol Young 2020 Jun 16:1-4. Epub 2020 Jun 16.

Division of Radiology, Puerta del Mar University Hospital, Cadiz, Spain.

We present our recent experience with a 6-month-old infant with a personal history of short bowel syndrome that presented with fever, cyanosis, and cardiogenic shock secondary to severe pulmonary hypertension and right ventricular failure without pulmonary thromboembolism. He did not present signs of toxin-mediated disease or Kawasaki disease. He was finally diagnosed with SARS-CoV-2 infection. Read More

Blood Adv 2020 Jul;4(13):2918-2926

Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.

Systemic chronic active Epstein-Barr virus infection (sCAEBV) was defined as a T- or NK-cell neoplasm in the 2017 World Health Organization (WHO) classification. To clarify the clinical features of sCAEBV under this classification and review the effects of chemotherapy, we performed a nationwide survey in Japan from 2016 through 2018 of patients with sCAEBV newly diagnosed from January 2003 through March 2016. One hundred cases were evaluated. Read More

Circ Res 2020 Jun 29. Epub 2020 Jun 29.

Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, CHINA.

Kawasaki disease (KD) is an acute vasculitis of early childhood that can result in per-manent coronary artery structural damage. The etiology for this arterial vulnerability in up to 15% of KD patients is unknown. Vascular smooth muscle cell (VSMC) dedifferentiation play a key role in the pathophysiology of medial damage and aneurysm formation, recognized arterial pathology in KD. Read More

J Diabetes Investig 2020 Jun 28. Epub 2020 Jun 28.

Division of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Aims: Continuous glucose monitoring (CGM) metrics, such as times in range (TIR) and time below range (TBR), have been shown to be useful as clinical targets that complement HbA1c for patients with type 2 diabetes mellitus (T2DM). We investigated the relationships between TIR, glycemic variability, and patient characteristics in patients with T2DM.

Materials And Methods: We performed CGM in 281 outpatients with T2DM who participated in a multicenter cohort (Hyogo Diabetes Hypoglycemia Cognition Complications) study. Read More

Cardiovasc Interv Ther 2020 Jun 26. Epub 2020 Jun 26.

Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.

Background: Japanese patients have shown improved outcomes after treatment with drug eluting stents compared with Western patients. Outcomes with the ridaforolimus-eluting EluNIR stent in Japanese patients are unknown.

Methods And Results: This was a multi-center trial in Japanese patients undergoing PCI with the ridaforolimus eluting EluNIR stent. Read More

Korean Circ J 2020 Jul;50(7):641-643

Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.

This corrects the article on p. 755 in vol. 49, PMID: 31074226. Read More

Pediatr Int 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatrics, Jichi Medical University, Tochigi, Japan.

J Eur Acad Dermatol Venereol 2020 Jun 25. Epub 2020 Jun 25.

Department of Internal Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090, Jette, Brussels, Belgium.

During the Coronavirus 2019 (COVID-19) pandemic, several associated skin conditions were reported in infected patients, including; urticaria [1], exanthema [1], erythema multiforme [2], chickenpox-like vesicles [1], pityriasis rosea [3], herpes simplex reactivation [4], erythema nodosum like Sweet's syndrome [5], Symmetrical Drug-Related Intertriginous and Flexural Exanthema [6], petechial rash [7], vasculitic purpura [7], acro-ischemia/necrosis [8], Kawasaki disease [2] and chilblain lesions [9]. Read More

Eur J Cardiothorac Surg 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatric Cardiothoracic Surgery, University of California, San Francisco, San Francisco, CA, USA.

Significant achievements in paediatric cardiology, surgical treatment and intensive care of congenital heart disease have drastically changed clinical outcomes for paediatric patients. Nevertheless, late-onset heart failure in children after staged surgeries still remains a serious concern in the medical community. Heart transplantation is an option for treatment; however, the shortage of available organs is a persistent problem in many developed countries. Read More

J Pediatr 2020 Jun 22. Epub 2020 Jun 22.

Professor of Pediatrics and of Microbiology and Immunology Northwestern University Feinberg School of Medicine The Ann & Robert H. Lurie Children's Hospital of Chicago Chicago, IL. Electronic address:

J Med Virol 2020 Jun 25. Epub 2020 Jun 25.

Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai.

In December 2019, the 2019 novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as low risk for severe COVID-19. Read More

Paediatr Int Child Health 2020 Jun 25:1-20. Epub 2020 Jun 25.

Division of Infectious Diseases, Department of Pediatrics and Internal Medicine, University of Saskatchewan , Saskatoon, Saskatchewan, Canada.

Coronaviruses, seven of which are known to infect humans, can cause a spectrum of clinical presentations ranging from asymptomatic infection to severe illness and death. Four human coronaviruses (hCoVs)-229E, HKU1, NL63 and OC43-circulate globally, commonly infect children and typically cause mild upper respiratory tract infections. Three novel coronaviruses of zoonotic origin have emerged during the past two decades: severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV) and the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Read More

Indian Pediatr 2020 Jun 24. Epub 2020 Jun 24.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Context: Preliminary data on coexistence of secondary hemophagocytic lymphohistiocytosis syndrome (HLH) and disseminated intravascular coagulation (DIC) in critically ill children with novel coronavirus disease (COVID-19) are emerging. Herein, we summarize the available literature and fill-in the gaps in this regard.

Evidence Acquisition: We have performed a literature search for articles in PubMed, EMBASE and Google Scholar databases till May 12, 2020, with following keywords: "COVID-19", "SARS-CoV-2", "HLH", "HScore", "coagulopathy", "D-dimer", "cytokine storm", "children" and "pediatrics" with interposition of Boolean operator "AND". Read More

Endoscopy 2020 Jun 24. Epub 2020 Jun 24.

Department of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan.

Background:  Prospectively collected long-term data of patients undergoing endoscopic resection for superficial esophageal squamous cell carcinoma (ESCC) are limited. The aim of this study was to determine the prospectively collected long-term outcomes of endoscopic resection for ESCC as a secondary analysis of the Japan Esophageal Cohort (JEC) study.

Methods: Patients who underwent endoscopic resection of intramucosal ESCC at 16 institutions between September 2005 and May 2010 were enrolled in the JEC study. Read More

Open Access Rheumatol 2020 4;12:87-89. Epub 2020 Jun 4.

Pediatric Pulmonology Department, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Kawasaki disease is a mysterious childhood vasculitis. It presents with multi-systemic involvement in which the prolonged high-grade fever and mucocutaneous and lymph node manifestations are the prominent features. Sometimes, the disease has an unusual, atypical or incomplete presentation. Read More

J Phys Ther Sci 2020 Jun 2;32(6):385-390. Epub 2020 Jun 2.

Division of Occupational Therapy, School of Rehabilitation, Kumamoto Health Science University, Japan.

[Purpose] To clarify the cutoff point of the Functional Independence Measure tool for predicting home discharge of patients in convalescent rehabilitation wards. [Participants and Methods] This retrospective observational study analyzed the data of 91 inpatients with cerebrovascular disease who received rehabilitation treatment at a convalescent rehabilitation ward. We categorized the participants into two groups: the home-discharged group and the non-home discharged group. Read More

S D Med 2020 Jun;73(6):246-251

Department of Pediatrics and Pediatric Critical Care, Avera McKennan Children's Hospital and University Health Center.

Coronavirus infectious disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was deemed a worldwide pandemic by the World Health Organization in February 2020. The U.S. Read More

World J Surg 2020 Jun 23. Epub 2020 Jun 23.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.

Background: The role of surgery in the management of primary cystic duct carcinoma (CDC) remains unclear especially in advanced disease. This study aimed to evaluate long-term outcomes in patients undergoing surgery for primary CDC.

Methods: From a multi-institutional database, we identified 41 patients who underwent surgery for primary CDC, defined as a part of gallbladder carcinoma with the tumor centre located in the cystic duct. Read More

medRxiv 2020 Jun 7. Epub 2020 Jun 7.

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, U.K.

Background: During the COVID-19 outbreak, reports have surfaced of children who present with features of a multisystem inflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome - Paediatric Inflammatory Multisystem Syndrome- temporally associated with SARS-CoV-2 pandemic (PIMS-TS). Initial reports find that many of the children are PCR-negative for SARS-CoV-2, so it is difficult to confirm whether this syndrome is a late complication of viral infection in an age group largely spared the worst consequences of this infection, or if this syndrome reflects enhanced surveillance.

Methods: Children hospitalised for symptoms consistent with PIMS-TS between 28 April and 8 May 2020, and who were PCR-negative for SARS-CoV-2, were tested for antibodies to viral spike glycoprotein using an ELISA test. Read More

Acta Med Okayama 2020 Jun;74(3):185-190

Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco, CA 94158, USA.

Heart diseases are one of the major causes of morbidity and mortality worldwide. Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. Stem cell therapy has emerged as one option for the treatment of a variety of heart diseases. Read More

Sci Rep 2020 Jun 23;10(1):10211. Epub 2020 Jun 23.

Women's and children's Hospital affiliated to Chengdu Medical College. Sichuan Women's and Children's Hospital, Chengdu, 610045, China.

This study was to investigate the correlation of vagal activity with coronary artery lesion (CAL) in Kawasaki disease (KD) children, and assess the predictive value of heart rate deceleration capacity (DC) for CAL in acute phase of KD.50 KD children with CAL, 130 KD children without CAL, 30 children with acute upper respiratory infection and 100 healthy children were recruited and indicators reflecting vagal activity including DC were measstuogram. KD children with CAL showed decreased vagal activity with significantly lower values of DC. Read More

Antibodies (Basel) 2020 Jun 19;9(2). Epub 2020 Jun 19.

Division of Plasma Protein Therapeutics, Office of Tissue and Advanced Therapies (OTAT), Center for Biologics Evaluation and Research (CBER), Food & Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA.

Immunoglobulins (IGs) are widely used for the treatment of immunodeficiency syndromes and several autoimmune diseases. In neonates, IGs have been used for the treatment of alloimmune thrombocytopenia, in neonatal infections and in the rare cases of neonatal Kawasaki disease. This review aims to examine the various dosing regimens of IGs following intravenous (IV) and subcutaneous (SC) administration, pharmacokinetics (PK) of IGs, and the importance of trough values for the prevention of infections in patients with primary immune deficiency (PID). Read More

Emerg Microbes Infect 2020 Dec;9(1):1514-1522

Rheumatology Department, centre Viggo Petersen, Paris, France.

We previously made the hypothesis that STING contributes to COVID-19. The present review detail new arguments for over-activation of STING pathways in COVID-19, following the description of hyper-coagulability and Kawasaki-like diseases in children. Indeed, Kawasaki disease is induced by overreaction of innate cells following exposition to various viruses, including herpes viruses which trigger STING. Read More

Ann Rheum Dis 2020 Jun 22. Epub 2020 Jun 22.

Professor Emeritus, Università degli Studi di Genova, Genoa, Italy.

BMJ 2020 06 22;369:m2418. Epub 2020 Jun 22.

Universidad San Martin de Porres, Facultad de Ciencias Administrativas y Recursos Humanos, Instituto de Consumo, Lima, Peru.

Zhongguo Dang Dai Er Ke Za Zhi 2020 Jun;22(6):614-619

Department of Pediatrics, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan 412000, China.

Objective: To study the association of the polymorphisms of the serum amyloid A1 (SAA1) gene at rs4638289 and rs7131332 loci with Kawasaki disease (KD) and its complication coronary artery lesion (CAL) in children.

Methods: A total of 105 Han children with KD who were hospitalized and treated from 2013 to 2017 were enrolled as the KD group. A total of 100 Han children who underwent physical examination were enrolled as the control group. Read More

J Chin Med Assoc 2020 Jun 15. Epub 2020 Jun 15.

Department of Pediatrics, National Yang-Ming University, Taipei, Taiwan, ROC.