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Int J Emerg Med 2022 May 21;15(1):21. Epub 2022 May 21.

Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain.

Background: Eczema herpeticum, also known as Kaposi varicelliform eruption, is a potentially life-threatening disseminated cutaneous viral infection. In the majority of cases, this condition develops as a complication in patients with atopic dermatitis. However, it may arise in a wide spectrum of pre-existing skin conditions, including psoriasis, seborrheic dermatitis, contact dermatitis, cutaneous T cell lymphoma, pemphigus vulgaris, and others. Read More

J Drugs Dermatol 2022 May;21(5):523-525

Atopic Dermatitis (AD) is one of the most common inflammatory skin conditions. AD is generally characterized by eczematous and pruritic skin lesions, although it can present differently between individuals. There are multiple comorbidities for AD, including asthma, food allergies, and ocular disorders such as conjunctivitis. Read More

Cells 2022 04 14;11(8). Epub 2022 Apr 14.

Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.

Individuals with underlying chronic skin conditions, notably atopic dermatitis (AD), are disproportionately affected by infections from members of the herpesviridae, papovaviridae, and poxviridae families. Many patients with AD experience recurrent, widespread cutaneous viral infections that can lead to viremia, serious organ complications, and even death. Little is known about how the type 2 inflammatory environment observed in the skin of AD patients impacts the susceptibility of epidermal cells (keratinocytes) to viral pathogens. Read More

Med Clin (Barc) 2022 06 21;158(11):566. Epub 2022 Mar 21.

Dermatology Department, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain.

J Eur Acad Dermatol Venereol 2022 Jun 25;36(6):807-819. Epub 2022 Feb 25.

Department of Dermatology, Amsterdam Public Health, Infection and Immunity, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Atopic dermatitis is a heterogeneous disease, accompanied by a wide variation in disease presentation and the potential to identify many phenotypes that may be relevant for prognosis and treatment. We aimed to systematically review previously reported phenotypes of atopic dermatitis and any characteristics associated with them. Ovid EMBASE, Ovid MEDLINE and Web of Science were searched from inception till 12 February 2021 for studies attempting to classify atopic dermatitis. Read More

BMC Infect Dis 2021 Dec 14;21(1):1247. Epub 2021 Dec 14.

Department of Obstetrics and Gynaecology, Rinku General Medical Centre, 2-23, Rinku Ourai-Kita, Izumisano, Osaka, 598-8577, Japan.

Background: Eczema herpeticum (EH) is a severe skin complication caused by human simplex virus (HSV) infection concomitant with immune dysfunction and dermatological conditions, mainly atopic dermatitis. We present the first case of EH subsequent to sepsis-related immunological suppression in pregnancy.

Case Presentation: Septic shock developed in a 30-year-old primiparous woman at 14 weeks of pregnancy during admission for hyperemesis gravidarum. Read More

J Allergy Clin Immunol Pract 2021 12 6;9(12):4468-4469. Epub 2021 Sep 6.

Department of Pediatrics, the First People's Hospital of Jiashan, Zhejiang, China. Electronic address:

Eur J Intern Med 2021 10 28;92:111-112. Epub 2021 Aug 28.

Department of Dermatology, Venereology and Leprology; Postgraduate Institute of Medical Education and Research; Chandigarh 160012, India. Electronic address:

Clin Case Rep 2021 Aug 16;9(8):e04589. Epub 2021 Aug 16.

Di.S.Sal., University of Genoa Genoa Italy.

Cannabinoid abuse may facilitate disseminated skin infection by herpes viruses in predisposed patients. These patients should be counselled about that. Read More

Pediatr Allergy Immunol 2022 01 24;33(1):e13648. Epub 2021 Aug 24.

Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles, Los Angeles, CA, USA.

mSphere 2021 08 28;6(4):e0060821. Epub 2021 Jul 28.

Division of Allergy/Immunology, Department of Pediatrics, National Jewish Healthgrid.240341.0, Denver, Colorado, USA.

Atopic dermatitis (AD) is a condition affecting 30 million persons in the United States. AD patients are heavily infected with Staphylococcus aureus on the skin. A particularly severe form of AD is eczema herpeticum (ADEH), where the patients' AD is complicated by S. Read More

J Osteopath Med 2021 07 15;121(10):825-826. Epub 2021 Jul 15.

HCA Healthcare/USF Morsani College of Medicine, Largo Medical Center in Largo, St. Petersburg, FL, USA.

Clin Exp Dermatol 2021 Dec 2;46(8):1603. Epub 2021 Aug 2.

Department of Dermatology, Galway University Hospital, Newcastle, Galway, Ireland.

Med Clin North Am 2021 Jul;105(4):783-797

Department of Dermatology, University of Alabama at Birmingham, 510 20th Street South, FOT Suite 858, Birmingham, AL 35233, USA. Electronic address:

This evidence-based review highlights cutaneous infections of bacterial, viral, and fungal origin that are frequently encountered by clinicians in all fields of practice. With a focus on treatment options and management, the scope of this article is to serve as a reference for physicians, regardless of field of specialty, as they encounter these pathogens in clinical practice. Read More

Allergy 2021 10 3;76(10):3017-3027. Epub 2021 May 3.

Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases leading to pruritic skin lesions. A subset of AD patients exhibits a disseminated severe HSV infection called eczema herpeticum (EH) that can cause life-threatening complications. This review gives an overview of the clinical picture, and characteristics of the patients as well as the diagnosis and therapy of EH. Read More

Am Fam Physician 2021 03;103(5):305-306

Saint Louis University Southwestern Illinois Family Medicine Residency, O'Fallon, IL, USA.

Allergy 2021 08 15;76(8):2510-2523. Epub 2021 Mar 15.

Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD, USA.

Background: Eczema herpeticum (EH) is a rare complication of atopic dermatitis (AD) caused by disseminated herpes simplex virus (HSV) infection. The role of rare and/or deleterious genetic variants in disease etiology is largely unknown. This study aimed to identify genes that harbor damaging genetic variants associated with HSV infection in AD with a history of recurrent eczema herpeticum (ADEH+). Read More

Case Rep Dermatol Med 2020 30;2020:6695342. Epub 2020 Dec 30.

Department of Dermatology and Venerology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Haemorrhagic crusted lesions over pre-existing pemphigus vulgaris erosions should arouse suspicion of Kaposi varicelliform eruption (KVE). Immediate treatment with antivirals helps to prevent mortality and morbidities. Here, we report a case of a 67-year-old male who developed haemorrhagic crusted lesions on pre-existing pemphigus lesions during his hospital stay and obtained almost 90% resolution of cutaneous lesions of Pemphigus vulgaris as well as Kaposi varicelliform eruption within 2 weeks of acyclovir treatment along with the continuation of systemic steroids. Read More

Clin Exp Allergy 2021 03 14;51(3):382-392. Epub 2021 Jan 14.

Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Atopic dermatitis (AD) is a chronic relapsing inflammatory cutaneous disease that is often associated with other atopic symptoms, such as food allergy, allergic rhinitis and asthma, leading to significant morbidity and healthcare costs. The pathogenesis of AD is complicated and multifactorial. Although the aetiology of AD remains incompletely understood, recent studies have provided further insight into AD pathophysiology, demonstrating that the interaction among genetic predisposition, immune dysfunction and environmental provocation factors contributes to its development. Read More

Dermatol Ther 2020 11 9;33(6):e14500. Epub 2020 Nov 9.

Department of Dermatovenereology, Third Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Prague, Czech Republic.

Actas Dermosifiliogr (Engl Ed) 2021 Jan 25;112(1):71. Epub 2020 Sep 25.

Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

Cutis 2020 07;106(1):E12-E14

Department of Pathology and Laboratory Medicine, Dermatopathology Division, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Indian J Dermatol 2020 Jul-Aug;65(4):304-306

Department of Dermatology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Crusted scabies is a rare and extremely contagious infestation by . Kaposi's varicelliform eruption (KVE) refers to herpes simplex virus infection superimposed on pre-existing dermatosis such as atopic dermatitis, Darier's disease, and pemphigus. We report a case of KVE superimposed on crusted scabies in a middle-aged woman. Read More

Cutis 2020 Jun;105(6):E38-E41

Department of Dermatopathology, Veterans Affairs Medical Center, Kansas City, USA.

Turk J Pediatr 2020 ;62(3):514-519

Department of Pediatric Allergy and Clinical Immunology, Health Sciences University Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.

Background: Eczema herpeticum (EH) is an acute disseminated viral infection that develops in the presence of an existing skin lesion, often on the ground of atopic dermatitis (AD). Morbidity and mortality of EH can be minimized by starting antiviral therapy at the earliest time in diagnosis.

Case: Herein we report five infants diagnosed with EH in the course of AD treatment. Read More

Cutis 2020 03;105(3):132-136

Division of Dermatology, Loyola University Medical Center, Maywood, Illinois, USA.

Many pediatric skin conditions can be safely monitored with minimal intervention, but certain skin conditions are emergent and require immediate attention and proper assessment of the neonate, infant, or child. We review the following pediatric dermatology emergencies so that clinicians can detect and accurately diagnose these conditions to avoid delayed treatment and considerable morbidity and mortality if missed: staphylococcal scalded skin syndrome (SSSS), impetigo, eczema herpeticum (EH), Langerhans cell histiocytosis (LCH), infantile hemangioma (IH), and IgA vasculitis. Read More

Cutis 2019 Nov;104(5):295-296

Department of Dermatology, Indiana University School of Medicine, Indianapolis, USA.

Eczema herpeticum has been well described in the setting of atopic dermatitis (AD) and other dermatoses. We present the case of a 2-month-old infant boy with cutaneous herpes simplex virus (HSV) infection within existing diffuse infantile seborrheic dermatitis. Providers should be aware that cutaneous HSV can be confined to a seborrheic distribution and may represent underlying epidermal dysfunction secondary to seborrheic dermatitis. Read More

Clin Rev Allergy Immunol 2020 Aug;59(1):1-18

Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, Université de Poitiers, Poitiers, France.

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the world. AD is a complex pathology mainly characterized by an impaired skin barrier, immune response dysfunction, and unbalanced skin microbiota. Moreover, AD patients exhibit an increased risk of developing bacterial and viral infections. Read More

Cureus 2019 Oct 14;11(10):e5907. Epub 2019 Oct 14.

Surgery, Burn Center, The Johns Hopkins University School of Medicine, Baltimore, USA.

Familial benign pemphigus, or Hailey-Hailey disease (HHD), is a rare (1 in 50,000), benign, autosomal dominant cutaneous disorder that causes a painful rash and blistering commonly occurring in the intertriginous folds. Despite having a good prognosis, there is no cure for HHD and the disease can be quite debilitating to the quality of life. The complexity of HHD can be compounded by superimposed eczema herpeticum (EH) or Kaposi's varicelliform eruption, which is caused by a viral infection occurring in preexistent cutaneous conditions. Read More

Pediatr Infect Dis J 2020 04;39(4):263-266

From the Emory University School of Medicine, Atlanta, Georgia.

Background: Atopic dermatitis (AD) predisposes to viral skin infections, such as eczema herpeticum (EH), and to bacterial skin infections, such as those caused by Staphylococcus aureus (SA) and group A streptococcus (GAS). This study evaluated clinical features of EH and its frequency of codetection with SA or GAS in children hospitalized for presumed AD skin infection.

Methods: We retrospectively reviewed clinical data for children ≤18 years of age admitted to a large hospital system for AD with presumed skin infection from January 2004 to December 2018. Read More