143 results match your criteria Kaposi Sarcoma Thoracic


Chylous ascites in disseminated Kaposi sarcoma: an unusual manifestation as immune reconstitution inflammatory syndrome.

BMJ Case Rep 2019 Mar 22;12(3). Epub 2019 Mar 22.

Department of Internal Medicine, Hospital de Cascais, Cascais, Portugal.

A 29-year-old man with diarrhoea, fever, abdominal pain and multiple purple papular lesions, neither pruriginous nor painful, was diagnosed with HIV-1 infection and disseminated Kaposi sarcoma (KS) with gastrointestinal involvement. He was started on highly active antiretroviral therapy immediately, as well as doxorubicin. Three weeks later, the patient developed bilateral moderate pleural effusion and large-volume ascites compatible with chylothorax and chylous ascites. Read More

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http://dx.doi.org/10.1136/bcr-2018-228406DOI Listing
March 2019
1 Read

Human immunodeficiency virus-negative multicentric Castleman's disease coexistent with Kaposi's sarcoma on F-FDG PET/CT: A case report.

Mol Clin Oncol 2019 Feb 11;10(2):318-320. Epub 2018 Dec 11.

Department of Nuclear Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Gyeonggi 420-767, Republic of Korea.

Multicentric Castleman's disease and Kaposi's sarcoma are more frequently observed in human immunodeficiency virus (HIV)-infected patients; however, 40-50% of the cases are HIV-negative. The present study reports the case of a 61-year-old man who presented with palpable masses in the axillary and right inguinal areas. The blood test results revealed increased serum erythrocyte sedimentation rate and C-reactive protein level, with negative serological markers, including for HIV. Read More

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http://dx.doi.org/10.3892/mco.2018.1789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327215PMC
February 2019
9 Reads

Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.

Proc Natl Acad Sci U S A 2018 12 19;115(50):12805-12810. Epub 2018 Nov 19.

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

Noncoding RNAs have substantial effects in host-virus interactions. Circular RNAs (circRNAs) are novel single-stranded noncoding RNAs which can decoy other RNAs or RNA-binding proteins to inhibit their functions. The role of circRNAs is largely unknown in the context of Kaposi's sarcoma herpesvirus (KSHV). Read More

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http://dx.doi.org/10.1073/pnas.1816183115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294913PMC
December 2018
2 Reads

Primary effusion lymphoma of the pleural space: Report of a rare complication of cardiac transplant with review of the literature.

Transpl Infect Dis 2019 Feb 30;21(1):e13005. Epub 2018 Oct 30.

Division of Pulmonary, Critical Care, and Sleep Medicine, Westchester Medical Center, Valhalla, New York.

Primary effusion lymphoma (PEL) is a rare mature B-cell non-Hodgkin's lymphoma arising in body cavities and presenting with effusions. It has been described predominantly in patients with impaired immunity from the acquired immunodeficiency syndrome and is associated with the Human Herpesvirus-8 (HHV-8). Seldom has PEL been diagnosed in persons negative for the human immunodeficiency virus (HIV), and in such cases it has occurred primarily in the setting of posttransplant immunosuppression. Read More

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http://dx.doi.org/10.1111/tid.13005DOI Listing
February 2019
16 Reads

A case of recipient-derived pulmonary Kaposi sarcoma after bilateral lung transplantation.

J Heart Lung Transplant 2018 Jun;37(6):798-799

Department of Pulmonary Critical Care, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.healun.2018.01.1310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420782PMC
June 2018
6 Reads

Central Venous Catheters: A Closer Look at the Subclavian Vein Approach.

R I Med J (2013) 2018 05 1;101(4):31-33. Epub 2018 May 1.

Associate Professor of Diagnostic & Interventional Radiology, Warren Alpert Medical School of Brown University; Rhode Island Medical Imaging.

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Recurrent Kaposi sarcoma associated with Koebner phenomenon in two HIV-seronegative patients: Two case reports and a review of the literature.

Medicine (Baltimore) 2017 Dec;96(52):e9467

Immunology and Molecular Oncology, Veneto Institute of Oncology, IOV IRCCS.

Rationale: Koebner phenomenon is occasionally reported in patients affected by classic Kaposi sarcoma (KS).

Patient Concerns: Here, we report 2 cases of KS associated with Koebner phenomenon and the correlation of human herpesvirus 8 molecular analysis with the clinical outcome.

Interventions: In the first case, a patient with a history of sporadic cutaneous KS developed a recurrent lesion at the laryngeal tract, the site of a previous nodulectomy. Read More

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http://dx.doi.org/10.1097/MD.0000000000009467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392972PMC
December 2017
5 Reads

[TB/HIV co-infection associated with Kaposi's sarcoma under opioid substitution treatment using methadone: about a case].

Pan Afr Med J 2017 15;28:43. Epub 2017 Sep 15.

Service des Maladies Infectieuses et Tropicales, Centre Hospitalier National Universitaire de Fann Dakar /Université Cheikh Anta Diop de Dakar, BP 5035 Dakar, Sénégal.

Late diagnosis of HIV infection can be fatal because it favors the appearance of opportunistic infections whose management requires the use of several molecules which can cause drug interactions. We report the case of a 45-year old female patient under heroin substitution treatment, using methadone and with HIV1 under antiretroviral treatment. This patient had nonspecific pulmonary appearance associated with dry nagging cough and progressive dyspnea evolving in a feverish context. Read More

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http://dx.doi.org/10.11604/pamj.2017.28.43.11161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687882PMC
December 2017
46 Reads

Kaposiform haemangioendothelioma in a nine-year-old boy with Kasabach-Merritt phenomenon.

Br J Haematol 2017 10 17;179(1). Epub 2017 Jul 17.

Department of Dermatology and Venereology, Capital Institute of Paediatrics, Beijing, China.

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http://dx.doi.org/10.1111/bjh.14837DOI Listing
October 2017
8 Reads

Simultaneous presentation of two noninflammatory lung diseases in an HIV-infected patient.

Ann Thorac Med 2017 Apr-Jun;12(2):125-126

Department of Family and Community Medicine, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid 28046, Spain.

The simultaneous presentation of two noninflammatory pulmonary diseases, pulmonary alveolar proteinosis and Kaposi's sarcoma (Ks), in an HIV-infected patient, is described. A 29-year-old black race patient was admitted to the hospital because of general malaise, weight loss, dyspnea, chest pain, and cough with hemoptoic expectoration. Chest X-rays revealed a patchy bilateral alveolar pattern with a tendency toward the formation of condensations. Read More

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http://dx.doi.org/10.4103/atm.ATM_335_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399687PMC
May 2017
7 Reads

Identical Presentation of Scapular Osteolysis in Two Patients with Thoracic Kaposiform Hemangioendothelioma.

Pediatr Dermatol 2017 May 6;34(3):e146-e149. Epub 2017 Apr 6.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.

Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor that does not metastasize. We report two unique cases of KHE involving the right hemithorax and the upper ipsilateral extremity. Kasabach-Merrit phenomenon and osteolytic lesions in the scapula were observed in both cases. Read More

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http://dx.doi.org/10.1111/pde.13114DOI Listing
May 2017
11 Reads

Usefulness of Endobronchial Ultrasound in Patients with Human Immunodeficiency Virus Infection and Mediastinal Lymphadenopathy.

Respiration 2017 30;93(6):424-429. Epub 2017 Mar 30.

Unidad de Neumología Intervencionista, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.

Background: There are few published studies about the usefulness of endobronchial ultrasound (EBUS) in patients infected with human immunodeficiency virus (HIV). The clinical spectrum of likely diseases in this population is varied and differs from patients not infected with HIV.

Objective: The aim of this study was to measure the usefulness of EBUS-guided transbronchial needle aspiration (EBUS-TBNA) in HIV-infected patients with mediastinal lymphadenopathy. Read More

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https://www.karger.com/Article/FullText/465527
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http://dx.doi.org/10.1159/000465527DOI Listing
March 2018
14 Reads

Chronic cough conundrum: a case report of a new diagnosis of HIV and pulmonary Kaposi's sarcoma.

BMC Pulm Med 2017 03 20;17(1):52. Epub 2017 Mar 20.

, 4745 Ogletown-Stanton Road, MAP 1, Suite 220, Newark, DE, 19713, USA.

Background: When evaluating a common complaint such as cough, clinicians should rely on a patient's history and physical to guide them, but also not diverge from guidelines in screening and testing lest certain diagnoses be overlooked.

Case Presentation: A 44 year old Hispanic male presented to a pulmonologist's office after failing multiple courses of antibiotics for chronic cough, now six months in duration. He described intermittent scant hemoptysis and an evanescent migratory non-pruritic rash occasionally noted on his trunk or limbs. Read More

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http://dx.doi.org/10.1186/s12890-017-0395-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360020PMC
March 2017
13 Reads

Pulmonary Kaposi Sarcoma with Osseous Metastases in an Human Immunodeficiency Virus (HIV) Patient: A Remarkable Response to Highly Active Antiretroviral Therapy.

Am J Case Rep 2017 Feb 20;18:181-185. Epub 2017 Feb 20.

Department of Infectious Diseases, Saint Francis Medical Center, Trenton, NJ, USA.

BACKGROUND Kaposi sarcoma (KS) is known to involve the mucocutaneous tissues and the aero-digestive tracts. In acquired immune deficiency syndrome (AIDS) patients, KS has an aggressive course and carries poor prognosis. We present a case of pulmonary KS with osseous metastases as the first presentation of human immunodeficiency virus (HIV) infection in a young male. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328198PMC
February 2017
8 Reads

Long-term outcome for kaposiform hemangioendothelioma: A report of two cases.

Pediatr Blood Cancer 2017 02 4;64(2):284-286. Epub 2016 Oct 4.

Department of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.

Kaposiform hemangioendothelioma (KHE) is a rare aggressive vascular tumor of skin and deep soft tissues that typically presents in infancy and may be associated with a potentially life-threatening coagulopathy known as Kasabach-Merrit phenomenon (KMP). Recent advances in medical therapy have successfully treated many patients. However, our knowledge regarding the natural history of these lesions and optimum surveillance strategies remains rudimentary. Read More

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http://dx.doi.org/10.1002/pbc.26224DOI Listing
February 2017
13 Reads

Rapidly progressive infiltrated plaques in a transplant recipient.

Actas Dermosifiliogr 2017 04 24;108(3):255-256. Epub 2016 Sep 24.

Hospital Puerta de Hierro, Majadahonda, Madrid, España.

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http://dx.doi.org/10.1016/j.ad.2016.05.007DOI Listing
April 2017
4 Reads

Kaposi Sarcoma of the eyelid as an initial manifestation of AIDS.

Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.

Department of Dermatovenereology of Centro Hospitalar de Lisboa Norte, Lisboa, Portugal.

Kaposi sarcoma (KS) is a multifocal systemic disease that originates in the vascular endothelium related to Human Herpes Virus 8 (HHV-8). In the early 1980s the first series of cases of disseminated Kaposi Sarcoma in HIV infected patients were reported. However, with the advent of highly active antiretroviral therapy (HAART) since 1997, these cases are less frequently observed by clinicians. Read More

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July 2016
34 Reads

Imaging features of kaposiform lymphangiomatosis.

Pediatr Radiol 2016 Aug 6;46(9):1282-90. Epub 2016 Apr 6.

Vascular Anomalies Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Background: Kaposiform lymphangiomatosis is a rare, aggressive lymphatic disorder. The imaging and presenting features of kaposiform lymphangiomatosis can overlap with those of central conducting lymphatic anomaly and generalized lymphatic anomaly.

Objective: To analyze the imaging findings of kaposiform lymphangiomatosis disorder and highlight features most suggestive of this diagnosis. Read More

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http://dx.doi.org/10.1007/s00247-016-3611-1DOI Listing
August 2016
36 Reads

Pulmonary Kaposi's Sarcoma and Its Complications in the HAART Era: A Contemporary Case-Based Review.

Lung 2016 Feb 29;194(1):163-9. Epub 2016 Jan 29.

Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1232, New York, NY, 10029-6754, USA.

The early years of the acquired immunodeficiency syndrome (AIDS) epidemic introduced the global medical community to Kaposi's sarcoma (KS), a heretofore seldom encountered angiosarcomatous neoplasm associated with human herpesvirus-8. At that time, clinicians treating these KS patients were routinely exposed to the pulmonary manifestations of this malignancy, including characteristic airway lesions, peribronchovascular opacities, and the typically hemorrhagic pleural effusions. They also witnessed uncommon complications of pulmonary KS such as chylous effusions, diffuse alveolar hemorrhage, and immune reconstitution inflammatory syndrome. Read More

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http://dx.doi.org/10.1007/s00408-015-9830-7DOI Listing
February 2016
5 Reads

Pulmonary Kaposi Sarcoma.

Authors:
Michael Gottlieb

CJEM 2016 09 16;18(5):399-400. Epub 2015 Jul 16.

*Department of Emergency Medicine,Cook County (Stroger) Hospital,Chicago,IL.

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http://dx.doi.org/10.1017/cem.2015.72DOI Listing
September 2016
7 Reads

Mesothelial Cells Within Vascular Transformation of Mediastinal Lymph Node Sinuses: An Unusual Benign Collision Mimicking Colliding Malignancies.

Int J Surg Pathol 2016 Apr 21;24(2):121-3. Epub 2015 Dec 21.

American University of Beirut Medical Center, Beirut, Lebanon

Vascular transformation of lymph node sinuses represents a rare benign entity mimicking malignant counterparts such as nodal Kaposi sarcoma. The presence of mildly atypical benign mesothelial cells within nodal sinuses raises the possibility of metastatic malignancy. Herein, a rare case of vascular transformation of lymph node sinuses with reactive sinusoidal mesothelial cells is outlined as a unique benign pathology and a potential mimicker of a malignant collision tumor. Read More

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http://dx.doi.org/10.1177/1066896915622277DOI Listing
April 2016
9 Reads

Disseminated Kaposi's sarcoma.

Arch Iran Med 2015 Nov;18(11):793-5

Hematology and Oncology Department, Uromia University of Medical Sciences, Uromia, Iran.

Kaposi's Sarcomas (KS) have been associated with many conditions and also known as a typical complication of immunosuppression. It should be considered as an important differential diagnosis in skin lesions of patients after solid organ transplantation. This is a report of a 61-year-old man, who presented with disseminated KS and a history of renal transplantation. Read More

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http://dx.doi.org/0151811/AIM.0011DOI Listing
November 2015
5 Reads

Pulmonary Kaposi sarcoma and disseminated Mycobacterium genavense infection in an HIV-infected patient.

BMJ Case Rep 2015 Oct 8;2015. Epub 2015 Oct 8.

Department of Internal Medicine, Hospital of Braga, Braga, Portugal.

We report a case of Kaposi sarcoma (KS) and disseminated infection by Mycobacterium genavense in a 40-year-old HIV-positive man with CD4+ T-cell count 5/µL. He presented with anorexia, diarrhoea, cachexia and multiple firm violaceous nodules distributed over the face, neck and upper and lower extremities. Biopsy of a skin nodule was performed, confirming KS. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2015-21168
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http://dx.doi.org/10.1136/bcr-2015-211683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600798PMC
October 2015
5 Reads

Kasabach-Merritt syndrome, kaposiform haemangioendothelioma and platelet blockade.

Br J Haematol 2015 Oct 26;171(1):11. Epub 2015 Jun 26.

Department of Haematology, Our Lady's Children's Hospital, Dublin 12, Ireland.

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http://dx.doi.org/10.1111/bjh.13558DOI Listing
October 2015
3 Reads

Long-Standing Presternal Plaque.

Actas Dermosifiliogr 2015 Sep 25;106(7):585. Epub 2015 Apr 25.

Unidad de Gestión Clínica de Dermatología Médico Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves, Granada, España.

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https://linkinghub.elsevier.com/retrieve/pii/S00017310150014
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http://dx.doi.org/10.1016/j.ad.2015.02.006DOI Listing
September 2015
4 Reads

Classic Kaposi Sarcoma: to treat or not to treat?

BMC Res Notes 2015 Apr 10;8:138. Epub 2015 Apr 10.

Department of Medical Oncology, University Campus Bio-Medico, via Alvaro del Portillo 21, Rome, Italy.

Background: Classic Kaposi Sarcoma (KS) is vascular sarcoma, known to be more common in Mediterranean elderly men and characterized by an indolent clinical behavior. To our knowledge, this is the first evidence in literature, describing a spontaneous partial regression in a non-HIV, non-iatrogenic KS.

Case Presentation: A 68-years old woman, presenting with weight loss and respiratory symptoms, was diagnosed with a classic KS involving lungs and mediastinal lymph nodes. Read More

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http://dx.doi.org/10.1186/s13104-015-1076-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395989PMC
April 2015
22 Reads

Multifocal kaposiform hemangioendothelioma of soft tissue with bilateral pulmonary involvement in an adolescent.

Korean J Pediatr 2014 Nov 30;57(11):500-4. Epub 2014 Nov 30.

Department of Pediatric Radiology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor of intermediate malignancy with resemblance to Kaposi sarcoma. It occurs predominantly in pediatric age groups as a cutaneous lesion with focal infiltration into the adjacent soft tissue and bone. Although visceral involvement is very uncommon, several cases with bone, retroperitoneal, or mediastinal involvement have been described. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2014.57.11
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http://dx.doi.org/10.3345/kjp.2014.57.11.500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279012PMC
November 2014
12 Reads

Castleman's Disease with Paraneoplastic Pemphigus.

Indian J Dermatol 2014 Jul;59(4):421

Department of Neurology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.

Castleman's disease is a rare autoimmune disorder with varied clinical presentations. Castleman's commonly involves mediastinum and hence it is thoracic in most of the reported cases. Paraneoplastic pemphigus (PNP) and myasthenia gravis can be associated with multicentric Castleman's disease. Read More

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http://dx.doi.org/10.4103/0019-5154.135528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103295PMC
July 2014
6 Reads

Thoracic diseases associated with HIV infection in the era of antiretroviral therapy: clinical and imaging findings.

Radiographics 2014 Jul-Aug;34(4):895-911

From the Department of Radiology (S.H.S.C., S.J.P., E.J.S., J.D.G., S.N.P.) and Division of Pulmonary and Critical Care Medicine (K.C.), University of Washington, 1959 NE Pacific St, UW Mailbox 357115, Seattle, WA 98195-7115.

The human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) pandemic has entered its 4th decade. Since the introduction of combination antiretroviral therapy (ART) in 1996, the number of AIDS-related deaths has plateaued worldwide. Today, owing to the effectiveness of ART, the HIV-infected population is aging and HIV infection has become a chronic illness. Read More

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http://pubs.rsna.org/doi/10.1148/rg.344130115
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http://dx.doi.org/10.1148/rg.344130115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319520PMC
November 2015
12 Reads

Paclitaxel for relapsed or recurrent HIV-associated pediatric Kaposi's sarcoma.

AIDS 2014 Mar;28(5):800-2

aTexas Children's Hospital bTexas Children's Cancer and Hematology Centers, Texas Children's Hospital Global Health Service Corps, Botswana-Baylor Children's Clinical Center of Excellence, Princess Marina Hospital, Texas, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000157DOI Listing
March 2014
5 Reads

Laryngomalacia and complicated, life-threatening mTOR-positive Kaposiform hemangioendothelioma cured by Supraglottoplasty and sirolimus.

Klin Padiatr 2014 Nov 8;226(6-7):362-8. Epub 2014 May 8.

Department of Pediatric Surgery, University Hospital of Schleswig-Holstein, Luebeck, Germany.

The therapy of complicated Kaposiform hemangioendothelioma (KHE) is still difficult. We present the first case of laryngomalacia with simultaneous mammalian target of Rapamycin (mTOR)-positive KHE of the neck and thoracic inlet and concurrent Kasabach-Meritt Phenomenon (KMP) in an 11-month-old boy suffering life-threatening progress despite intravenous vincristine, corticosteroids, propranolol and local interstitial laser-application. The laryngomalacia restored after laser-supraglottoplasty. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1372587
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http://dx.doi.org/10.1055/s-0034-1372587DOI Listing
November 2014
13 Reads

A man with oral lesions, constipation and back pain.

Int J STD AIDS 2014 Jun 18;25(7):526-8. Epub 2013 Dec 18.

Division of Infectious Diseases, University of California San Francisco, Fresno Medical Education Program, Fresno, CA, USA.

We describe an unusual presentation of disseminated Kaposi sarcoma in a 49-year-old African-American man with AIDS who was admitted to the hospital for constipation and back pain. Magnetic resonance imagings of the thoracic and lumbar spine were grossly abnormal, however, a biopsy of the iliac crest was interpreted as normal. The patient remained a diagnostic enigma until disseminated Kaposi sarcoma was suspected, based on vascular plaque-like lesions observed on his hard palate and right conjunctiva. Read More

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http://dx.doi.org/10.1177/0956462413515660DOI Listing
June 2014
5 Reads

Incidence of primary skin cancer after organ transplantation: An 18-year single-center experience in Korea.

J Am Acad Dermatol 2014 Mar 15;70(3):465-72. Epub 2013 Dec 15.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Skin cancer is the most common malignancy to arise after organ transplantation in Caucasians, but limited data are available on its incidence in Asian transplant recipients.

Objective: We sought to assess the incidence of skin cancer after organ transplantation in a Korean cohort.

Methods: A cohort study was conducted to determine the incidence and risk factors for skin cancers among kidney, liver, heart, or pancreas transplant recipients, treated at the Asan Medical Center in Seoul, Korea. Read More

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http://dx.doi.org/10.1016/j.jaad.2013.10.024DOI Listing
March 2014
5 Reads

Expansile kaposiform hemangioendothelioma deformed thoracic cage in an adult.

Ann Thorac Surg 2013 Nov;96(5):1854-7

Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Kaposiform hemangioendothelioma is a vascular tumor that commonly presents as a cutaneous mass, is observed in children, and is associated with Kasabach-Merritt phenomenon. Herein we report a case of kaposiform hemangioendothelioma with chest wall deformity in an adult who did not show the Kasabach-Merritt phenomenon or cutaneous lesions. To our knowledge, this is the first case of asymptomatic kaposiform hemangioendothelioma arising from the pleura and deforming the chest wall. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2013.02.059DOI Listing
November 2013
5 Reads

Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies.

PLoS Pathog 2013 18;9(7):e1003484. Epub 2013 Jul 18.

Lineberger Comprehensive Cancer Center, Program in Global Oncology, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

MicroRNAs (miRNAs) are stable, small non-coding RNAs that modulate many downstream target genes. Recently, circulating miRNAs have been detected in various body fluids and within exosomes, prompting their evaluation as candidate biomarkers of diseases, especially cancer. Kaposi's sarcoma (KS) is the most common AIDS-associated cancer and remains prevalent despite Highly Active Anti-Retroviral Therapy (HAART). Read More

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http://dx.doi.org/10.1371/journal.ppat.1003484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715412PMC
February 2014
78 Reads

Lymphadenopathic Kaposi's sarcoma in an immunocompetent adult.

J Coll Physicians Surg Pak 2012 Jun;22(6):403-5

Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.

Kaposi's sarcomas (KS) are vascular lesions which usually originate from multiple sites in the mid-dermis extending to the dermis. The aetiology is unknown, but infection from human herpes virus type 8 has been suggested. Several reports of KS had come from Africa initially and from worldwide later due to the close association with HIV/AIDS. Read More

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http://dx.doi.org/06.2012/JCPSP.403405DOI Listing
June 2012
42 Reads

Prognosis in primary effusion lymphoma is associated with the number of body cavities involved.

Leuk Lymphoma 2012 Dec 13;53(12):2378-82. Epub 2012 Jun 13.

Division of Hematology and Oncology, Department of Medicine, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI, USA.

Primary effusion lymphoma (PEL) is a rare lymphoma associated with Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), and characterized by a malignant body cavity effusion without solid organ or nodal involvement. Prognostic factors in patients with PEL have not been systematically studied. We conducted a literature search for patients with HHV8-positive PEL to identify potential prognostic factors for survival. Read More

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http://dx.doi.org/10.3109/10428194.2012.694075DOI Listing
December 2012
10 Reads

Immune reconstitution inflammatory syndrome of Kaposi's sarcoma in an HIV-infected patient.

J Microbiol Immunol Infect 2013 Aug 12;46(4):309-12. Epub 2012 Apr 12.

Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.

We present a case of Kaposi's sarcoma-related immune reconstitution inflammatory syndrome in an HIV-infected patient who developed fever, worsening pulmonary infiltrates with respiratory distress, and progression of skin tumors at the popliteal region and thigh that resulted in limitation on movement of the right knee joint at 3.5 months following a significant increase of CD4 count after combination antiretroviral therapy. Read More

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http://dx.doi.org/10.1016/j.jmii.2012.01.006DOI Listing
August 2013
9 Reads

Hemangioendothelioma: a rare case of a primary intracardiac tumor.

Pediatr Cardiol 2013 Jan 16;34(1):194-7. Epub 2012 Mar 16.

Children's National Medical Center, 111 Michigan Avenue, Washington, DC 20010, USA.

Kaposiform hemangioendothelioma (KH) is a rare tumor of vascular origin that commonly affects the cutaneous tissues of the extremities. It can, however, affect the abdomen, thorax, head, or neck. Compared with juvenile hemangiomas, which tend to regress, KH tumors are locally aggressive and usually persist. Read More

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http://dx.doi.org/10.1007/s00246-012-0280-1DOI Listing
January 2013
8 Reads

Vascular endothelial growth factor receptor 2 as a marker for malignant vascular tumors and mesothelioma: an immunohistochemical study of 262 vascular endothelial and 1640 nonvascular tumors.

Am J Surg Pathol 2012 Apr;36(4):629-39

Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.

Vascular endothelial growth factor receptor 2 (VEGFR2) is a primary responder to vascular endothelial growth factor signal and thereby regulates endothelial migration and proliferation. This receptor is expressed in endothelial cells and in some vascular tumors, but many reports also detail its expression in carcinomas and lymphomas. VEGFR2 is a potential cell-type marker, and data on VEGFR2 expression may also have therapeutic significance in view of recent availability of VEGFR2 inhibitors. Read More

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http://dx.doi.org/10.1097/PAS.0b013e318243555bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310951PMC
April 2012
5 Reads

Beyond skin deep: thoracic manifestations of systemic disorders affecting the skin.

Radiographics 2011 Oct;31(6):1651-68

Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, MC 3252, Madison, WI 53792-3252, USA.

A variety of systemic disorders--infections, noninfectious inflammatory diseases, collagen vascular diseases, hereditary diseases, and acquired immune deficiency diseases--may affect both the skin and the lung. The findings in one organ system can help establish the diagnosis or limit the differential diagnosis. Cutaneous manifestations of many conditions (eg, Kaposi sarcoma) precede thoracic manifestations and sometimes have prognostic implications for respiratory disease; in other conditions (eg, organizing pneumonia in polymyositis and dermatomyositis), thoracic manifestations precede cutaneous ones. Read More

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http://dx.doi.org/10.1148/rg.316115516DOI Listing
October 2011
7 Reads

Pulmonary and cutaneous nodules in an immunocompromised patient.

Thorax 2011 Dec 6;66(12):1103, 1108. Epub 2011 Oct 6.

Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, Biopolis 41110, Larissa, Greece.

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http://thorax.bmj.com/cgi/doi/10.1136/thoraxjnl-2011-200757
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http://dx.doi.org/10.1136/thoraxjnl-2011-200757DOI Listing
December 2011
5 Reads

Disseminated Kaposi sarcoma in newly diagnosed HIV.

Infection 2011 Feb 4;39(1):91. Epub 2011 Feb 4.

Department of Internal Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s15010-011-0083-yDOI Listing
February 2011
2 Reads

Kaposiform hemangioendothelioma in multiple spinal levels without skin changes.

Clin Orthop Relat Res 2009 Sep 21;467(9):2464-71. Epub 2009 Apr 21.

Department of Orthopedics and Rehabilitation, University of Vermont/Fletcher Allen Health Care, 426C Stafford Hall, 95 Carrigan Avenue, Burlington, VT 05405-0084, USA.

Kaposiform hemangioendothelioma is a rare vascular tumor of childhood that is locally aggressive but has little metastatic potential and by itself is not known to be lethal. It most commonly presents as a superficial or deep soft tissue mass with associated cutaneous lesions. Kasabach-Merritt phenomenon, a condition characterized by profound thrombocytopenia and life-threatening hemorrhage, often is associated with kaposiform hemangioendothelioma. Read More

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http://dx.doi.org/10.1007/s11999-009-0838-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866913PMC
September 2009
5 Reads

Non-infective pulmonary disease in HIV-positive children.

Pediatr Radiol 2009 Jun 20;39(6):555-64. Epub 2009 Mar 20.

Department of Radiology, Tygerberg Academic Hospital, University of Stellenbosch, Faculty of Health Sciences, Tygerberg, Cape Town, South Africa.

It is estimated that over 90% of children infected with human immunodeficiency virus (HIV) live in the developing world and particularly in sub-Saharan Africa. Pulmonary disease is the most common clinical feature of acquired immunodeficiency syndrome (AIDS) in infants and children causing the most morbidity and mortality, and is the primary cause of death in 50% of cases. Children with lung disease are surviving progressively longer because of earlier diagnosis and antiretroviral treatment and, therefore, thoracic manifestations have continued to change and unexpected complications are being encountered. Read More

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http://dx.doi.org/10.1007/s00247-009-1156-2DOI Listing
June 2009
13 Reads

KSHV/HHV8-associated intestinal Kaposi's sarcoma in patient with ulcerative colitis receiving immunosuppressive drugs: report of a case.

Dis Colon Rectum 2009 Jan;52(1):154-8

Service d'Anatomie et Cytologie Pathologiques, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France.

Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), has been identified in all four forms of Kaposi's sarcoma (classic, endemic, HIV-associated and iatrogenic). We report the rare case of an intestinal (small intestine and rectosigmoid) Kaposi's sarcoma in a 62-year-old HIV-negative man with ulcerative colitis. This patient was receiving immunosuppressive therapy with steroids and azathioprine. Read More

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http://dx.doi.org/10.1007/DCR.0b013e318197217fDOI Listing
January 2009
10 Reads

Concurrent Kaposi's sarcoma, tuberculosis, and allograft dysfunction in a renal transplant patient.

Saudi J Kidney Dis Transpl 2009 Mar;20(2):270-3

Nephrology Division, Department of Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.

The major long-term complications of renal transplantation (RT) include cardio-vascular disease, opportunistic infections, malignancies, and chronic allograft nephropathy. Long-term complications are generally considered as those occurring more than 1 year post trans-plantation; however, some of the complications can occur earlier. We present a 58-year-old man who presented with multiple complications of RT concurrently and relatively early post trans-plantation including Kaposi's sarcoma, tuberculosis and allograft dysfunction. Read More

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March 2009
3 Reads

[Thymoma associated with pure red cell aplasia and Kaposi's sarcoma].

Rev Mal Respir 2009 Jan;26(1):78-82

Service de pneumo-allergologie, CHU Hédi Chaker, Sfax, Tunisie.

Introduction: Thymoma is a rare tumor which represents about 20% of mediastinal tumors. It is associated with several parathymic conditions. A second cancer frequently occurs during long term follow up. Read More

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January 2009
3 Reads

Conjunctival Kaposi's sarcoma in HIV-positive heterosexual Nigerian woman--a case report.

West Afr J Med 2008 Jan;27(1):50-2

Department of Medicine, University of Ilorin Teaching Hospital, Kwara State Nigeria.

Background: Neoplastic conditions are increasingly been encountered in HIV/AIDS patients. Till date only two cases of conjunctiva Kaposi sarcoma (KS) have been reported in the background of HIV and both in males.

Objective: To present a 27-year-old African woman with histologically proven conjunctival KS and marked CD4+ cell depletion and to reinforce the fact that KS is an important differential of conjunctival tumour especially in the background of immunosupression in Africa. Read More

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January 2008
2 Reads

Kaposi sarcoma in unusual locations.

BMC Cancer 2008 Jul 7;8:190. Epub 2008 Jul 7.

Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA.

Kaposi sarcoma (KS) is a multifocal, vascular lesion of low-grade malignant potential that presents most frequently in mucocutaneous sites. KS also commonly involves lymph nodes and visceral organs. This article deals with the manifestation of KS in unusual anatomic regions. Read More

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http://dx.doi.org/10.1186/1471-2407-8-190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464778PMC
July 2008
4 Reads