12,510 results match your criteria Kaposi Sarcoma Thoracic


African Kaposi's Sarcoma.

Acta Med Port 2018 Nov 30;31(11):697. Epub 2018 Nov 30.

Department of Dermatology. Santa Maria University Hospital. Lisbon. Institute for Hygiene and Tropical Medicine. Universidade NOVA. Lisbon. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

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November 2018
3 Reads

Ribonucleotide Reductase Inhibitor 3-AP Induces Oncogenic Virus Infected Cell Death and Represses Tumor Growth.

J Cancer 2018 31;9(23):4503-4509. Epub 2018 Oct 31.

Department of Pediatrics, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human malignancies, particularly Kaposi's Sarcoma (KS), which preferentially arise in immunocompromised patients such as HIV+ subpopulation while still lacking of effective therapeutic options. We recently found that the ribonucleotide reductase (RR) subunit M2 is potentially regulated by the key oncogenic HGF/c-MET pathway in KSHV-related lymphoma cells. One of RR inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) effectively induced apoptosis of KSHV+ lymphomas and suppressed tumor progression . Read More

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October 2018

[Opportunistic infections: What's new?]

Dtsch Med Wochenschr 2018 Dec 3;143(24):1755-1758. Epub 2018 Dec 3.

Klinische Arbeitsgemeinschaft AIDS Deutschland (KAAD), Sektion der Deutschen AIDS-Gesellschaft (DAIG).

Guidelines from 3 clinical societies and peer-reviewed publications have been reviewed for recent changes in the management of opportunistic infections. Trimethoprim and sulfamethoxazol administered intravenously is an option to treat cerebral toxoplasmosis if oral therapy is not feasible. CD4 T cell cut-off for starting prophylaxis with trimethoprim and sulfamethoxazole is now 200/µl. Read More

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December 2018

Palmoplantar lymphangioma-like Kaposi sarcoma.

J Dtsch Dermatol Ges 2018 Dec 3. Epub 2018 Dec 3.

Servicio de Dermatología, Hospital de Cabueñes, Gijón, Asturias, Spain.

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December 2018

Human Oncoviruses: Mucocutaneous Manifestations, Pathogenesis, Therapeutics, and Prevention (Part II: Hepatitis Viruses, Human T-cell Leukemia Viruses, Herpesviruses, and Epstein-Barr Virus).

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

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November 2018

Nanomedicine for cutaneous tumors - lessons since the successful treatment of the Kaposi sarcoma.

Nanomedicine (Lond) 2018 Nov 30. Epub 2018 Nov 30.

Genetics & Morphology Department, Institute of Biological Science, University of Brasilia, Brasília DF 70910-900, Brazil.

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November 2018

Cutaneous Sarcomas.

Hematol Oncol Clin North Am 2019 Feb;33(1):87-101

Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA; Cutaneous Oncology Program, Dana Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

Cutaneous sarcomas are rare malignancies that may present with a variety of clinical manifestations. This article focuses on 4 of the most common cutaneous sarcomas (Kaposi sarcoma, cutaneous angiosarcoma, dermatofibrosarcoma protuberans, and cutaneous leiomyosarcoma) and reviews clinical, diagnostic, and therapeutic aspects of these rare skin malignancies. Read More

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February 2019

Primary Gastrointestinal Kaposi's Sarcoma in a Patient with Human Immunodeficiency Virus.

Case Rep Oncol 2018 Sep-Dec;11(3):638-647. Epub 2018 Oct 22.

Internship in Medicine, Fundacion Universitaria Sanitas, Bogotá, Colombia.

Gastrointestinal bleeding in HIV patients secondary to coinfection by HHV8 and development of Kaposi's sarcoma (KS) is a rare complication even if no skin lesions are detected on physical examination. This article indicates which patients might develop this type of clinical sign and also tries to recall that absence of skin lesions never rules out the presence of KS, especially if gastrointestinal involvement is documented. Gastrointestinal bleeding in terms of hematemesis has rarely been reported in the literature. Read More

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October 2018
2 Reads

Acroangiodermatitis of Mali (Pseudo-Kaposi Sarcoma) Associated with Chronic Venous Insufficiency and Obesity: A Case Report.

Wounds 2018 Nov;30(11):E105-E107

College of Medicine, Taif University, Taif, Saudi Arabia.

Introduction: Acroangiodermatitis, also known as psesudo-Kapsoi sarcoma, is a rare and benign angioproliferative malady. It presents clinically as purple-colored plaques, patches, or nodules resembling Kaposi sarcoma and is often related to chronic venous insufficiency, arteriovenous malformation of the legs, paralyzed limbs, and residual limbs. Obesity is a risk factor for venous insufficiency and could be related to acroangiodermatitis. Read More

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November 2018
8 Reads

Endemic Kaposi sarcoma in HIV-negative children and adolescents: an evaluation of overlapping and distinct clinical features in comparison with HIV-related disease.

Infect Agent Cancer 2018 9;13:33. Epub 2018 Nov 9.

Baylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.

Background: Endemic Kaposi sarcoma (KS) was first described in African children over fifty years ago, but has recently been overshadowed by HIV-related disease. We aimed to evaluate the similarities and differences between endemic HIV-negative and epidemic HIV-positive pediatric KS in a KS-associated herpesvirus-endemic region of Africa.

Methods: We describe clinical characteristics of 20 HIV-negative children with endemic KS over a six-year period and compare findings with a historical control-an HIV-related pediatric KS cohort from Lilongwe, Malawi. Read More

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November 2018
5 Reads
2.070 Impact Factor

Kaposi's varicelliform eruption in a patient with metastatic melanoma and primary cutaneous anaplastic large cell lymphoma treated with talimogene laherparepvec and nivolumab.

J Immunother Cancer 2018 Nov 19;6(1):122. Epub 2018 Nov 19.

Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Background: Immune-directed therapies have become front-line therapy for melanoma and are transforming the management of advanced disease. In refractory cases, multi-modal immunoncology (IO) approaches are being utilized, including combining immune checkpoint blockade (ICB) with oncolytic herpes viruses. Talimogene laherparepvec (T-VEC) is the first genetically modified oncolytic viral therapy (OVT) approved for the treatment of recurrent and unresectable melanoma. Read More

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November 2018
7 Reads

High Cancer Burden Among Antiretroviral Therapy Users in Malawi: a Record Linkage Study of Observational HIV Cohorts and Cancer Registry Data.

Clin Infect Dis 2018 Nov 17. Epub 2018 Nov 17.

Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Background: With antiretroviral therapy (ART), AIDS-defining cancer incidence has declined and non-AIDS defining cancers are now more frequent among HIV-infected populations in high-income countries. In sub-Saharan Africa, limited epidemiological data describe cancer burden among ART users.

Methods: We used probabilistic algorithms to link cases from the population-based cancer registry with electronic medical records supporting ART delivery in the Malawi's two largest HIV cohorts, Lighthouse Trust (LT; 2007-2010) and Queen Elizabeth Central Hospital (QECH; 2000-2010). Read More

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November 2018
1 Read
8.890 Impact Factor

Experimental co-transmission of Simian Immunodeficiency Virus (SIV) and the macaque homologs of the Kaposi Sarcoma-Associated Herpesvirus (KSHV) and Epstein-Barr Virus (EBV).

PLoS One 2018 16;13(11):e0205632. Epub 2018 Nov 16.

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.

Macaque RFHV and LCV are close homologs of human KSHV and EBV, respectively. No experimental model of RFHV has been developed due to the lack of a source of culturable infectious virus. Screening of macaques at the Washington National Primate Research Center detected RFHV in saliva of SIV-infected macaques from previous vaccine studies. Read More

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November 2018
4 Reads

Protective Effect of PACAP on Ischemia/Reperfusion-Induced Kidney Injury of Male and Female Rats: Gender Differences.

J Mol Neurosci 2018 Nov 16. Epub 2018 Nov 16.

Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, Szigeti ut 12, Pecs, 7624, Hungary.

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that exerts general cytoprotective effects, including protection in different kidney disorders. The aim of our study was to investigate the ischemia/reperfusion-induced kidney injury of male and female rats to confirm the protective effects of PACAP in the kidney and to reveal possible gender differences.Male and female Wistar rats underwent unilateral renal artery clamping followed by 24-h, 48-h, or 14-day reperfusion. Read More

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November 2018
6 Reads

Epstein-Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus.

Proc Natl Acad Sci U S A 2018 Nov 14;115(48):E11379-E11387. Epub 2018 Nov 14.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC 27599

Primary effusion lymphoma (PEL) is a B cell lymphoma that is always associated with Kaposi's sarcoma-associated herpesvirus (KSHV) and in many cases also with Epstein-Barr virus (EBV); however, the requirement for EBV coinfection is not clear. Here, we demonstrate that adding exogenous EBV to KSHV single-positive PEL leads to increased KSHV genome maintenance and KSHV latency-associated nuclear antigen (LANA) expression. To show that EBV was necessary for naturally coinfected PEL, we nucleofected KSHV/EBV PEL cell lines with an EBV-specific CRISPR/Cas9 plasmid to delete EBV and observed a dramatic decrease in cell viability, KSHV genome copy number, and LANA expression. Read More

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November 2018
3 Reads

Dose and Exposure Time-Dependent Renal and Hepatic Effects of Intraperitoneally Administered Fumonisin B₁ in Rats.

Toxins (Basel) 2018 Nov 9;10(11). Epub 2018 Nov 9.

MTA-KE-SZIE Mycotoxins in the Food Chain Research Group, Kaposvár University, Guba S. u. 40., 7400 Kaposvár, Hungary.

Male Wistar rats were treated intraperitoneally (i.p.) with fumonisin B₁ (FB₁; 0, 20, 50 and 100 mg/kg dietary dose equivalent) for 5 and 10 days ( = 24⁻24 in each setting) to gain dose- and time-dependent effects on antioxidant status and oxidative stress response, clinical chemical endpoints and liver, kidney and lung histopathology and lymphocyte damage (genotoxicity). Read More

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November 2018
2 Reads
2.480 Impact Factor

A 32-Year-Old Man With HIV Infection, Pleural Effusions, and Lymphadenopathy.

Chest 2018 Nov;154(5):e147-e151

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX.

Case Presentation: A 32-year-old man presented with fever, nonproductive cough, diffuse lymphadenopathy, and polyarticular pain for 2 weeks. His medical history included HIV diagnosed 10 years ago, anal intraepithelial neoplasia, Kaposi sarcoma, and herpes simplex virus-2 infection. The patient was not receiving antiretroviral therapy or antibiotic prophylaxis, and his last known CD4 count a month before was 45 cells/mm. Read More

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November 2018
4 Reads

Randomized controlled trial to evaluate locally sourced two-component compression bandages for HIV-associated Kaposi sarcoma leg lymphedema in western Kenya: The Kenyan Improvised Compression for Kaposi Sarcoma (KICKS) study protocol.

Contemp Clin Trials Commun 2018 Dec 21;12:116-122. Epub 2018 Oct 21.

AMPATH (Academic Model Providing Access to Healthcare), Kenya.

Background: HIV-associated Kaposi sarcoma (KS), among the most frequent cancers seen in sub-Saharan Africa, is associated with a high prevalence of lymphedema. Lymphedema causes progressive functional impairment marked by swelling, physical discomfort, disfiguring changes, skin hardening from fibrosis, poor wound healing, and recurrent skin infection. While compression therapy is considered a major component of lymphedema management, this intervention has never been evaluated in HIV-associated KS lymphedema. Read More

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December 2018
8 Reads

[Acquired facial angiokeratoma].

Pan Afr Med J 2018 19;30:140. Epub 2018 Jun 19.

Service de Dermatologie-Vénérologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

Angiokeratomas are vascular dilations (telangiectasic papules) with keratotic surface caused by capillary dilation in the dermal papilla due to venous hyperpression, vascular malformation or a capillary fragility. They most commonly are benign and just unsightly and they may sometimes reveal a dreaded overload disease known as Fabry Disease. Here we report the case of a 56-year old patient, with no notable medical history, presenting with nontraumatic, nonpruritic, bleeding on contact, grouped cluster erythematous papules without extracutaneous manifestations on the left malar region, that had occurred 4 months before. Read More

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November 2018
3 Reads

Vastly Different Exercise Programs Similarly Improve Parkinsonian Symptoms: A Randomized Clinical Trial.

Gerontology 2018 Oct 26:1-8. Epub 2018 Oct 26.

University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Objectives: To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson's disease (PD) patients' mobility and clinical symptoms.

Design: Randomized clinical trial.

Setting: Outpatient physiotherapy clinic in a hospital. Read More

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October 2018
6 Reads

Kaposi sarcoma-An unusual cause of asymptomatic anemia.

Indian J Gastroenterol 2018 Sep;37(5):477-478

Gastroenterology Department, Hospital de Braga, Sete Fontes - São Victor, 4710-243, Braga, Portugal.

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September 2018

Plastic Bronchitis in an AIDS Patient with Pulmonary Kaposi Sarcoma.

Case Rep Pulmonol 2018 27;2018:9736516. Epub 2018 Sep 27.

Department of Medicine, Division of Infectious Diseases, UTH-SA, San Antonio, TX 78229, USA.

Plastic bronchitis is the expectoration of bronchial casts in the mold of the tracheobronchial tree. It is a rare occurrence of unknown etiology that has been primarily described in children with congenital heart disease. In this case report, we present the first reported case of plastic bronchitis in a patient with pulmonary Kaposi sarcoma and underlying HIV infection. Read More

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September 2018
9 Reads

Disseminated visceral Kaposi´s sarcoma in a pediatric bilateral lung transplant recipient.

Pediatr Transplant 2018 Oct 25:e13311. Epub 2018 Oct 25.

Department of Surgery, Hospital Nacional de Pediatría Dr. Prof. JP Garrahan, Buenos Aires, Argentina.

Cancer is a major adverse outcome of solid organ transplantation, and risks are especially high for malignancies caused by viral infections. HHV-8 is the etiologic agent of Kaposi´s sarcoma (KS). We report a case of visceral KS occurring in a 15-year-old patient after lung transplantation. Read More

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October 2018
5 Reads

Primary Kaposi Sarcoma of the Subcutaneous Tissue: A Rare Clinical Variant.

Actas Dermosifiliogr 2018 Oct 22. Epub 2018 Oct 22.

Departamento de Anatomía Patología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

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October 2018

Health-Related Quality of Life in Patients Treated With Antiretroviral Therapy Only Versus Chemotherapy and Antiretroviral Therapy for HIV-Associated Kaposi Sarcoma: A Randomized Control Trial.

J Glob Oncol 2018 Oct(4):1-9

Fahmida Shaik and Anisa Mosam, University of Kwa-Zulu Natal, Durban; Tonya Esterhuizen, Stellenbosch University, Stellenbosch, South Africa; and Thomas S. Uldrick, Fred Hutchinson Cancer Research Center, Seattle, WA.

Purpose: In sub-Saharan Africa, Kaposi sarcoma (KS) is the most common HIV-associated cancer. KS causes substantial morbidity, and treatment goals should emphasize quality of life (QOL). Antiretroviral therapy (ART) is indicated, and early chemotherapy significantly improves tumor regression. Read More

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October 2018
5 Reads

Castleman's disease in the HIV-endemic setting.

Cancer Manag Res 2018 12;10:4553-4563. Epub 2018 Oct 12.

Division of Haematology, Department of Pathology, University of Stellenbosch, Tygerberg Academic Hospital, Cape Town, South Africa.

Introduction: Castleman's disease (CD), first described by Benjamin Castleman in 1954, is a giant or angiofollicular lymph node hyperplasia, described as a rare monotypic polyclonal B-cell lymphoproliferative disorder with an incompletely understood pathogenesis and variable clinical behavior. This study aimed to determine the incidence of CD diagnosis over an 11-year period. Additionally, the study aimed to describe the demographic, laboratory, and pathological features of CD. Read More

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October 2018
1 Read

Human leukocyte antigen polymorphisms and Kaposi's sarcoma-associated herpesvirus infection outcomes: A call for deeper exploration.

J Med Virol 2018 Oct 21. Epub 2018 Oct 21.

Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

Host genetic background may influence the immunity to resist viral infection. As the most polymorphic loci in the entire human genome, the human leukocyte antigen (HLA) system plays an important role in innate and adaptive immune responses to many invading pathogens. Studies have shown that an association might exist between HLA polymorphisms and susceptibility to Kaposi's sarcoma-associated herpesvirus (KSHV) infection and associated diseases. Read More

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October 2018
1 Read
2.350 Impact Factor

Epidemiological trends and therapeutic challenges of malignancies in adult HIV-1-infected patients receiving combination antiretroviral therapy in a tertiary hospital from Romania: An observational retrospective study.

J Infect Public Health 2018 Oct 18. Epub 2018 Oct 18.

‟Carol Davila" University of Medicine and Pharmacy, Boulevard Eroii Sanitari, 8, Bucharest, Romania; National Institute for Infectious Diseases "Prof. Dr. Matei Balș", Dr. Calistrat Grozovici Street, 1, Bucharest, Romania. Electronic address:

Background: Malignancies have become a leading cause of morbidity and mortality in people living with HIV (PLHIV). The primary endpoint of our study was to describe the epidemiology of acquired immunodeficiency syndrome (AIDS)-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs). Epidemiological disparities, mortality predictors and survival analysis within the two groups of patients were key secondary endpoints. Read More

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October 2018
1 Read

HIV-related Malignancies and Mimics: Imaging Findings and Management.

Radiographics 2018 Nov-Dec;38(7):2051-2068. Epub 2018 Oct 19.

From the Departments of Diagnostic Radiology (S.J., K.S., A.O., C.T.J., K.M.E.) and Interventional Radiology (N.K.), University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030; Department of Diagnostic Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.); Department of Radiology, University of Utah, Salt Lake City, Utah (A.S.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (M.G.L.); and Department of Radiology, University of Missouri Health Care, Columbia, Mo (A.H.G.).

The risk of developing malignancy is higher in patients with human immunodeficiency virus (HIV) infection than in non-HIV-infected patients. Several factors including immunosuppression, viral coinfection, and high-risk lifestyle choices lead to higher rates of cancer in the HIV-infected population. A subset of HIV-related malignancies are considered to be acquired immunodeficiency syndrome (AIDS)-defining malignancies, as their presence confirms the diagnosis of AIDS in an HIV-infected patient. Read More

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October 2018
14 Reads
2.600 Impact Factor

A Series of Patients with Kaposi Sarcoma (Mediterranean/Classical Type): Case Presentations and Short Update on Pathogenesis and Treatment.

Open Access Maced J Med Sci 2018 Sep 20;6(9):1688-1693. Epub 2018 Sep 20.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev Nr 79, Sofia, Bulgaria.

Background: Kaposi's sarcoma was first described in 1872 by Moritz Kaposi. To date, it is considered a malignant disease is originating from the endothelial cells of the lymphatic vessels believed to be infected with HHV-8. The current classification defines four major epidemiological forms of Kaposi's sarcoma: classical, endemic, AIDS-associated, and iatrogenic. Read More

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September 2018
7 Reads

Beam Walking to Assess Dynamic Balance in Health and Disease: A Protocol for the "BEAM" Multicenter Observational Study.

Gerontology 2018 Oct 18:1-8. Epub 2018 Oct 18.

Division of Training and Movement Sciences, University of Potsdam, Potsdam, Germany.

Background: Dynamic balance keeps the vertical projection of the center of mass within the base of support while walking. Dynamic balance tests are used to predict the risks of falls and eventual falls. The psychometric properties of most dynamic balance tests are unsatisfactory and do not comprise an actual loss of balance while walking. Read More

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October 2018

A Reappraisal of Sex-Specific Cancer Survival Trends Among Adolescents and Young Adults in the United States.

J Natl Cancer Inst 2018 Oct 15. Epub 2018 Oct 15.

Los Angeles Cancer Surveillance Program, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Background: Cancer survival among adolescents and young adults (AYAs) was previously reported as showing little or no improvement compared to younger or older counterparts. The role of the HIV/AIDS epidemic in the AYA survival deficit has not been evaluated.

Methods: Using cancer registry data from the Surveillance, Epidemiology, and End Results program (SEER 9), we examined sex-specific 5-year relative survival trends for children (0-14 years old), AYAs (15-39 years old), and older adults (40 years and older) diagnosed with cancer during 1973-2009 and followed through the end of 2014. Read More

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October 2018
4 Reads

Oroxylin A inhibits Kaposi's sarcoma-associated herpes virus (KSHV) vIL-6-mediated lymphatic reprogramming of vascular endothelial cells through modulating PPARγ/Prox1 axis.

J Med Virol 2018 Oct 14. Epub 2018 Oct 14.

Department of Laboratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Background And Purpose: Kaposi's sarcoma-associated herpes virus (KSHV) vIL-6 is sufficient to induce lymphatic reprogramming of vascular endothelial cells, which is a key event in Kaposi's sarcoma (KS) development. This study was aimed to investigate the effect of Chinese herb oroxylin A on lymphatic reprogramming and neovascularization by KSHV vIL-6 in vitro and in vivo.

Methods: The lymphatic-phenotype endothelial cell line was generated by lentiviral KSHV vIL-6 infection. Read More

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October 2018
7 Reads

[Kaposi sarcoma in a patient with ANCA vasculitis requiring hemodialysis].

Rev Med Interne 2018 Dec 10;39(12):942-945. Epub 2018 Oct 10.

Service de Néphrologie, de dialyse et de transplantation rénale, CHU La Rabta, Tunis, Tunisie; Faculté de Médecine de Tunis, Université Tunis El Manar, Tunis, Tunisie.

Introduction: Iatrogenic Kaposi's sarcoma is widely reported after transplantation. Less commonly, it occurs in patients receiving immunosuppressive therapy for ANCA associated vasculitis. We report here the rare association of Kaposi's sarcoma, prurigo nodularis and ANCA associated vasculitis in a hemodialysis patient. Read More

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December 2018
5 Reads

MRI findings of AIDS-related giant facial Kaposi's sarcoma: A case report.

Medicine (Baltimore) 2018 Oct;97(41):e12530

Department of Radiology.

Rationale: Kaposi's sarcoma (KS) is the most common malignant tumor in HIV-infected people and occurs mainly in the skin, mucous membranes, and lymph nodes. Approximately 33% of the initial skin manifestations of AIDS and approximately 35% to 79% of KS occur during disease progression. Otherwise, AIDS-related facial KS that was simultaneously examined by magnetic resonance imaging (MRI) is rare. Read More

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October 2018
4 Reads

Ultrasonographic intraoperative monitoring and follow-up of Kaposi's sarcoma nodules under treatment with intralesional vincristine.

Skin Res Technol 2018 Oct 12. Epub 2018 Oct 12.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.

Background: Intralesional vincristine is an effective treatment for Kaposi's sarcoma (KS) nodules on the skin, but there is little evidence of its action through imaging techniques. Ultrasonography can be an adjunctive tool in the diagnosis and management of KS skin lesions, but data in the literature are few.

Materials And Methods: Five patients with classic KS nodules were treated with intralesional vincristine. Read More

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October 2018

Prognostic value of pre-embolisation MRI features of uterine fibroids in uterine artery embolisation.

Clin Radiol 2018 Dec 9;73(12):1060.e1-1060.e7. Epub 2018 Oct 9.

Department of Radiology, Semmelweis University, Budapest, Hungary. Electronic address:

Aim: To evaluate the prognostic value of pretreatment pelvic magnetic resonance imaging (MRI) features in uterine artery embolisation (UAE) for symptomatic fibroids.

Materials And Methods: MRI characteristics of 109 fibroids (≥3 cm) in 70 patients were analysed retrospectively. Imaging was performed 1. Read More

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December 2018
8 Reads

Two-Year Agility Maintenance Training Slows the Progression of Parkinsonian Symptoms.

Med Sci Sports Exerc 2018 Oct 9. Epub 2018 Oct 9.

University of Groningen, University Medical Center Groningen, The Netherlands.

Introduction: Parkinson's disease (PD) is a progressive neurodegenerative condition and it is unclear if long-term non-pharmaceutical interventions can slow the progression of motor and non-motor symptoms and lower drug dose.

Methods: In a randomized trial, after an initial 3-week-long, 15-session supervised high-intensity sensorimotor agility exercise (E) program designed to improve postural instability, the Exercise+Maintenance (E+M, n=19) group continued to exercise three times per week for 2 years, while E (n=16) and the no exercise and no maintenance control (C, n=20) continued habitual living. Eight outcomes were measured before and after the 3-week initial exercise program and then at 3, 6, 9, 12, 18, and 24 months in all patients. Read More

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October 2018

An audit of the diagnosis and reporting of soft tissue sarcomas at the Lagos University Teaching Hospital.

Niger J Clin Pract 2018 Oct;21(10):1330-1336

Department of Anatomic and Molecular Pathology, Lagos University Teaching Hospital, Lagos, Nigeria.

Background: : The effective management of patients with cancer is predicated on the right diagnoses and other relevant parameters included in the pathology report. This is particularly important in soft tissue pathology where arriving at the right diagnosis is often challenging. The aim of this study, therefore, was to perform an audit of sarcoma diagnosis and reporting in our institution. Read More

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October 2018

Kaposi sarcoma-associated herpes virus (KSHV) latent protein LANA modulates cellular genes associated with epithelial-to-mesenchymal transition.

Arch Virol 2018 Oct 4. Epub 2018 Oct 4.

Department of Microbiology, University of Delhi, South Campus, New Delhi, India.

Kaposi's sarcoma-associated herpes virus (KSHV) is a gammaherpesvirus associated with Kaposi's sarcoma and various lymphoproliferative diseases. Epithelial-to-mesenchymal transition (EMT) is an important step in the metastasis of cancer cells. Previous studies have shown an important role for EMT markers in B-cell malignancies. Read More

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October 2018
4 Reads

Social behavioral correlates of Kaposi sarcoma-associated herpesvirus infection among Han and Uygur populations in Xinjiang, China.

J Med Virol 2018 Oct 3. Epub 2018 Oct 3.

Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

Background: Kaposi sarcoma-associated herpesvirus (KSHV) is endemic in Xinjiang, China and its prevalence varies considerably across ethnic groups. The current study explored the prevalence and correlates of KSHV infection among Han and Uygur populations in Xinjiang.

Methods: A cross-sectional study, including 282 Han ethnicity and 312 Uygur, was conducted in Xinjiang, China. Read More

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October 2018
6 Reads
2.350 Impact Factor

Kaposi sarcoma in HIV-positive solid organ transplant recipients: A French multicentric national study and literature review.

Transplantation 2018 Oct 16. Epub 2018 Oct 16.

APHP Department of Dermatology, Saint Louis Hospital, Paris.

Background: Kaposi sarcoma is a vascular tumor related to herpesvirus-8 and is promoted by immunosuppression. For the last 15 years, HIV patients have had access to organ transplantation. The dual immunosuppression of HIV and immunosuppressive treatments might increase the risk and severity of Kaposi sarcoma. Read More

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October 2018
7 Reads
3.830 Impact Factor

Outcomes across the tuberculosis care continuum among adolescents in Haiti.

Public Health Action 2018 Sep;8(3):103-109

Center for Global Health, Weill Cornell Medical College, New York, New York, USA.

GHESKIO (Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes) clinic, Port-au-Prince, Haiti. To evaluate tuberculosis (TB) care continuum outcomes among adolescents. Among a retrospective cohort of 10-24 year olds diagnosed with active TB, we report completion of the following steps of the TB care continuum stratified by human immunodeficiency virus (HIV) status: diagnosis of microbiologically confirmed TB, initiation of anti-tuberculosis treatment, retention in care at 2 months on anti-tuberculosis treatment, and TB treatment success. Read More

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September 2018
5 Reads

Reasons for inpatient admissions to the dermatology department in Lomé, Togo : Trends between 1992 to 2005 and 2005 to 2016.

Med Sante Trop 2018 Aug;28(3):270-272

CHU Sylvanus Olympio, Lomé, Togo.

The aim of this study was to report the frequency of and reasons for dermatology admissions in Lomé (Togo) between 2005 and 2016. This retrospective study examined records from August 2005 to December 2016 from the dermatology departments of the two teaching hospitals in Lomé, Togo. During the study period, 454 (1. Read More

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August 2018
1 Read

Kaposi Sarcoma and Cutaneous Angiosarcoma: Guidelines for Diagnosis and Treatment.

Actas Dermosifiliogr 2018 Sep 24. Epub 2018 Sep 24.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España. Electronic address:

Kaposi sarcoma is a vascular sarcoma with 4 clinical variants: classic Kaposi sarcoma, which mainly affect the extremities of elderly patients and follows a chronic, generally indolent course; African Kaposi sarcoma; immunosuppression-associated Kaposi sarcoma; and AIDS-associated Kaposi sarcoma. Type8 human herpesvirus is the etiologic agent in all 4variants. Cutaneous angiosarcoma is a cutaneous neoplasm with a very poor prognosis. Read More

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September 2018
8 Reads

The mutation-dependent pathogenicity of NPHS2 p.R229Q: A guide for clinical assessment.

Hum Mutat 2018 Dec 22;39(12):1854-1860. Epub 2018 Oct 22.

MTA-SE Lendület Nephrogenetic Laboratory, Budapest, Hungary.

NPHS2, encoding podocin, is the major gene implicated in steroid-resistant nephrotic syndrome. Its c.686G>A, p. Read More

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December 2018
1 Read