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Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1910-1911

External auditory canal HIV-associated Kaposi sarcoma is rare. A 47-year-old male patient found a lump locked in the right external auditory canal gradually enlarging during the 4 months. Preoperative examination suggested that the patient had infected with HIV. Read More

J Natl Compr Canc Netw 2018 Dec;16(12):1418-1419

Moffitt Cancer Center and Research Institute, Tampa, FL.

Orv Hetil 2018 Sep;159(39):1593-1601

Egészségügyi Központ, Diagnosztikai és Onkoradiológiai Intézet, Kaposvári Egyetem Kaposvár, Szent Imre u. 14/B, 7400.

Introduction And Aim: The aim of our study was to investigate changes in clinical staging N (lymph node) and M (distant metastasis) in patients who receive PET/CT-based 3D radiotherapy within complex oncological treatment, and compare to conventional cross-sectional imaging staging technique. We also investigated the presence of PET/CT-detected second tumors and the effect of PET/CT on therapeutic decisions.

Method: From the 1st of January 2015 to the 30th of November 2016, 192 patients (n = 192) were treated with PET/CT-based radiation (109 head, 44 lung, 28 rectum and 11 cervical localization) in the Oncoradiology Institute of the Health Center of the University of Kaposvár. Read More

Cancer Treat Res 2019 ;177:1-21

Department of Dermatology, University of Texas Health Sciences Center at Houston, Houston, TX, 77030, USA.

Malignancies were one of the earliest recognized manifestations that led to the description of the acquired immune deficiency syndrome (AIDS). The majority of cancers in AIDS patients are associated with coinfection with oncogenic viruses, such as Epstein-Barr virus, human herpesvirus 8, and human papillomavirus, with resulting malignancies occurring secondary to diminished immune surveillance against viruses and virus-infected tumor cells. Over 50% of AIDS lymphomas are associated with Epstein-Barr virus (EBV) and/or HHV8 infection. Read More

Blood 2018 Dec;132(23):2525

The University of Texas MD Anderson Cancer Center.

Int J Cancer 2018 Dec 10. Epub 2018 Dec 10.

African Cancer Registry Network, Oxford, United Kingdom.

Gulu Cancer Registry was established in 2014 to assess the incidence and survival of cancer in 4 districts of the Acholi Sub-region of northern Uganda. Here we report the results of the first 4 years of registration (2013-2016) in this largely rural population of 771,514. In total there were 1,627 cases of cancers registered; 644 among men (corresponding to an ASR of 106. Read More

Semin Liver Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiology, BCLC Group, Hospital Clinic Barcelona, University of Barcelona, Barcelona, Spain.

Hepatic angiosarcoma and epithelioid hemangioendothelioma (EHE) might be clinically considered a spectrum since, although more frequently presenting indolent behavior, EHE occasionally evolves to high-grade neoplasms. However, in most circumstances, pathological and immunohistochemical patterns define this differential diagnosis. More recently, molecular pathways for angiosarcoma and for EHE from other organs and from soft tissue have been proved different, paving the way for future morpho-molecular assessment of their hepatic counterpart. Read More

Indian J Gastroenterol 2018 Dec 7. Epub 2018 Dec 7.

Division of Gastroenterology, Lenox Hill Hospital, New York, NY, USA.

Oncotarget 2018 Nov 9;9(88):35856-35869. Epub 2018 Nov 9.

AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Background: We previously reported Kaposi sarcoma-associated herpesvirus (KSHV) microRNA sequence variants in clinical samples correlated with increased risk of multicentric Castleman's disease (MCD). We then demonstrated that microRNAs with variant sequence have different maturation and mature microRNA expression . Here, we illustrate the association between microRNA sequence and changes in mature microRNA levels within Kaposi sarcoma (KS) lesions. Read More

Acta Med Port 2018 Nov 30;31(11):697. Epub 2018 Nov 30.

Department of Dermatology. Santa Maria University Hospital. Lisbon. Institute for Hygiene and Tropical Medicine. Universidade NOVA. Lisbon. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

J Cancer 2018 31;9(23):4503-4509. Epub 2018 Oct 31.

Department of Pediatrics, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human malignancies, particularly Kaposi's Sarcoma (KS), which preferentially arise in immunocompromised patients such as HIV+ subpopulation while still lacking of effective therapeutic options. We recently found that the ribonucleotide reductase (RR) subunit M2 is potentially regulated by the key oncogenic HGF/c-MET pathway in KSHV-related lymphoma cells. One of RR inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) effectively induced apoptosis of KSHV+ lymphomas and suppressed tumor progression . Read More

Dtsch Med Wochenschr 2018 Dec 3;143(24):1755-1758. Epub 2018 Dec 3.

Klinische Arbeitsgemeinschaft AIDS Deutschland (KAAD), Sektion der Deutschen AIDS-Gesellschaft (DAIG).

Guidelines from 3 clinical societies and peer-reviewed publications have been reviewed for recent changes in the management of opportunistic infections. Trimethoprim and sulfamethoxazol administered intravenously is an option to treat cerebral toxoplasmosis if oral therapy is not feasible. CD4 T cell cut-off for starting prophylaxis with trimethoprim and sulfamethoxazole is now 200/µl. Read More

J Dtsch Dermatol Ges 2018 Dec 3. Epub 2018 Dec 3.

Servicio de Dermatología, Hospital de Cabueñes, Gijón, Asturias, Spain.

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

Nanomedicine (Lond) 2018 Nov 30. Epub 2018 Nov 30.

Genetics & Morphology Department, Institute of Biological Science, University of Brasilia, Brasília DF 70910-900, Brazil.

Hematol Oncol Clin North Am 2019 Feb;33(1):87-101

Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA; Cutaneous Oncology Program, Dana Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

Cutaneous sarcomas are rare malignancies that may present with a variety of clinical manifestations. This article focuses on 4 of the most common cutaneous sarcomas (Kaposi sarcoma, cutaneous angiosarcoma, dermatofibrosarcoma protuberans, and cutaneous leiomyosarcoma) and reviews clinical, diagnostic, and therapeutic aspects of these rare skin malignancies. Read More

Case Rep Oncol 2018 Sep-Dec;11(3):638-647. Epub 2018 Oct 22.

Internship in Medicine, Fundacion Universitaria Sanitas, Bogotá, Colombia.

Gastrointestinal bleeding in HIV patients secondary to coinfection by HHV8 and development of Kaposi's sarcoma (KS) is a rare complication even if no skin lesions are detected on physical examination. This article indicates which patients might develop this type of clinical sign and also tries to recall that absence of skin lesions never rules out the presence of KS, especially if gastrointestinal involvement is documented. Gastrointestinal bleeding in terms of hematemesis has rarely been reported in the literature. Read More

Wounds 2018 Nov;30(11):E105-E107

College of Medicine, Taif University, Taif, Saudi Arabia.

Introduction: Acroangiodermatitis, also known as psesudo-Kapsoi sarcoma, is a rare and benign angioproliferative malady. It presents clinically as purple-colored plaques, patches, or nodules resembling Kaposi sarcoma and is often related to chronic venous insufficiency, arteriovenous malformation of the legs, paralyzed limbs, and residual limbs. Obesity is a risk factor for venous insufficiency and could be related to acroangiodermatitis. Read More

Infect Agent Cancer 2018 9;13:33. Epub 2018 Nov 9.

Baylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.

Background: Endemic Kaposi sarcoma (KS) was first described in African children over fifty years ago, but has recently been overshadowed by HIV-related disease. We aimed to evaluate the similarities and differences between endemic HIV-negative and epidemic HIV-positive pediatric KS in a KS-associated herpesvirus-endemic region of Africa.

Methods: We describe clinical characteristics of 20 HIV-negative children with endemic KS over a six-year period and compare findings with a historical control-an HIV-related pediatric KS cohort from Lilongwe, Malawi. Read More

J Immunother Cancer 2018 Nov 19;6(1):122. Epub 2018 Nov 19.

Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Background: Immune-directed therapies have become front-line therapy for melanoma and are transforming the management of advanced disease. In refractory cases, multi-modal immunoncology (IO) approaches are being utilized, including combining immune checkpoint blockade (ICB) with oncolytic herpes viruses. Talimogene laherparepvec (T-VEC) is the first genetically modified oncolytic viral therapy (OVT) approved for the treatment of recurrent and unresectable melanoma. Read More

Clin Infect Dis 2018 Nov 17. Epub 2018 Nov 17.

Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Background: With antiretroviral therapy (ART), AIDS-defining cancer incidence has declined and non-AIDS defining cancers are now more frequent among HIV-infected populations in high-income countries. In sub-Saharan Africa, limited epidemiological data describe cancer burden among ART users.

Methods: We used probabilistic algorithms to link cases from the population-based cancer registry with electronic medical records supporting ART delivery in the Malawi's two largest HIV cohorts, Lighthouse Trust (LT; 2007-2010) and Queen Elizabeth Central Hospital (QECH; 2000-2010). Read More

PLoS One 2018 16;13(11):e0205632. Epub 2018 Nov 16.

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.

Macaque RFHV and LCV are close homologs of human KSHV and EBV, respectively. No experimental model of RFHV has been developed due to the lack of a source of culturable infectious virus. Screening of macaques at the Washington National Primate Research Center detected RFHV in saliva of SIV-infected macaques from previous vaccine studies. Read More

J Mol Neurosci 2018 Nov 16. Epub 2018 Nov 16.

Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, Szigeti ut 12, Pecs, 7624, Hungary.

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that exerts general cytoprotective effects, including protection in different kidney disorders. The aim of our study was to investigate the ischemia/reperfusion-induced kidney injury of male and female rats to confirm the protective effects of PACAP in the kidney and to reveal possible gender differences.Male and female Wistar rats underwent unilateral renal artery clamping followed by 24-h, 48-h, or 14-day reperfusion. Read More

Proc Natl Acad Sci U S A 2018 Nov 14;115(48):E11379-E11387. Epub 2018 Nov 14.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC 27599

Primary effusion lymphoma (PEL) is a B cell lymphoma that is always associated with Kaposi's sarcoma-associated herpesvirus (KSHV) and in many cases also with Epstein-Barr virus (EBV); however, the requirement for EBV coinfection is not clear. Here, we demonstrate that adding exogenous EBV to KSHV single-positive PEL leads to increased KSHV genome maintenance and KSHV latency-associated nuclear antigen (LANA) expression. To show that EBV was necessary for naturally coinfected PEL, we nucleofected KSHV/EBV PEL cell lines with an EBV-specific CRISPR/Cas9 plasmid to delete EBV and observed a dramatic decrease in cell viability, KSHV genome copy number, and LANA expression. Read More

Toxins (Basel) 2018 Nov 9;10(11). Epub 2018 Nov 9.

MTA-KE-SZIE Mycotoxins in the Food Chain Research Group, Kaposvár University, Guba S. u. 40., 7400 Kaposvár, Hungary.

Male Wistar rats were treated intraperitoneally (i.p.) with fumonisin B₁ (FB₁; 0, 20, 50 and 100 mg/kg dietary dose equivalent) for 5 and 10 days ( = 24⁻24 in each setting) to gain dose- and time-dependent effects on antioxidant status and oxidative stress response, clinical chemical endpoints and liver, kidney and lung histopathology and lymphocyte damage (genotoxicity). Read More

Chest 2018 Nov;154(5):e147-e151

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX.

Case Presentation: A 32-year-old man presented with fever, nonproductive cough, diffuse lymphadenopathy, and polyarticular pain for 2 weeks. His medical history included HIV diagnosed 10 years ago, anal intraepithelial neoplasia, Kaposi sarcoma, and herpes simplex virus-2 infection. The patient was not receiving antiretroviral therapy or antibiotic prophylaxis, and his last known CD4 count a month before was 45 cells/mm. Read More

Contemp Clin Trials Commun 2018 Dec 21;12:116-122. Epub 2018 Oct 21.

AMPATH (Academic Model Providing Access to Healthcare), Kenya.

Background: HIV-associated Kaposi sarcoma (KS), among the most frequent cancers seen in sub-Saharan Africa, is associated with a high prevalence of lymphedema. Lymphedema causes progressive functional impairment marked by swelling, physical discomfort, disfiguring changes, skin hardening from fibrosis, poor wound healing, and recurrent skin infection. While compression therapy is considered a major component of lymphedema management, this intervention has never been evaluated in HIV-associated KS lymphedema. Read More

J Dermatol 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Pan Afr Med J 2018 19;30:140. Epub 2018 Jun 19.

Service de Dermatologie-Vénérologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

Angiokeratomas are vascular dilations (telangiectasic papules) with keratotic surface caused by capillary dilation in the dermal papilla due to venous hyperpression, vascular malformation or a capillary fragility. They most commonly are benign and just unsightly and they may sometimes reveal a dreaded overload disease known as Fabry Disease. Here we report the case of a 56-year old patient, with no notable medical history, presenting with nontraumatic, nonpruritic, bleeding on contact, grouped cluster erythematous papules without extracutaneous manifestations on the left malar region, that had occurred 4 months before. Read More

Gerontology 2018 Oct 26:1-8. Epub 2018 Oct 26.

University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Objectives: To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson's disease (PD) patients' mobility and clinical symptoms.

Design: Randomized clinical trial.

Setting: Outpatient physiotherapy clinic in a hospital. Read More

Indian J Gastroenterol 2018 Sep;37(5):477-478

Gastroenterology Department, Hospital de Braga, Sete Fontes - São Victor, 4710-243, Braga, Portugal.

Case Rep Pulmonol 2018 27;2018:9736516. Epub 2018 Sep 27.

Department of Medicine, Division of Infectious Diseases, UTH-SA, San Antonio, TX 78229, USA.

Plastic bronchitis is the expectoration of bronchial casts in the mold of the tracheobronchial tree. It is a rare occurrence of unknown etiology that has been primarily described in children with congenital heart disease. In this case report, we present the first reported case of plastic bronchitis in a patient with pulmonary Kaposi sarcoma and underlying HIV infection. Read More

Pediatr Transplant 2018 Oct 25:e13311. Epub 2018 Oct 25.

Department of Surgery, Hospital Nacional de Pediatría Dr. Prof. JP Garrahan, Buenos Aires, Argentina.

Cancer is a major adverse outcome of solid organ transplantation, and risks are especially high for malignancies caused by viral infections. HHV-8 is the etiologic agent of Kaposi´s sarcoma (KS). We report a case of visceral KS occurring in a 15-year-old patient after lung transplantation. Read More

Actas Dermosifiliogr 2018 Oct 22. Epub 2018 Oct 22.

Departamento de Anatomía Patología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

J Glob Oncol 2018 Oct(4):1-9

Fahmida Shaik and Anisa Mosam, University of Kwa-Zulu Natal, Durban; Tonya Esterhuizen, Stellenbosch University, Stellenbosch, South Africa; and Thomas S. Uldrick, Fred Hutchinson Cancer Research Center, Seattle, WA.

Purpose: In sub-Saharan Africa, Kaposi sarcoma (KS) is the most common HIV-associated cancer. KS causes substantial morbidity, and treatment goals should emphasize quality of life (QOL). Antiretroviral therapy (ART) is indicated, and early chemotherapy significantly improves tumor regression. Read More

Cancer Manag Res 2018 12;10:4553-4563. Epub 2018 Oct 12.

Division of Haematology, Department of Pathology, University of Stellenbosch, Tygerberg Academic Hospital, Cape Town, South Africa.

Introduction: Castleman's disease (CD), first described by Benjamin Castleman in 1954, is a giant or angiofollicular lymph node hyperplasia, described as a rare monotypic polyclonal B-cell lymphoproliferative disorder with an incompletely understood pathogenesis and variable clinical behavior. This study aimed to determine the incidence of CD diagnosis over an 11-year period. Additionally, the study aimed to describe the demographic, laboratory, and pathological features of CD. Read More

J Med Virol 2018 Oct 21. Epub 2018 Oct 21.

Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

Host genetic background may influence the immunity to resist viral infection. As the most polymorphic loci in the entire human genome, the human leukocyte antigen (HLA) system plays an important role in innate and adaptive immune responses to many invading pathogens. Studies have shown that an association might exist between HLA polymorphisms and susceptibility to Kaposi's sarcoma-associated herpesvirus (KSHV) infection and associated diseases. Read More

J Infect Public Health 2018 Oct 18. Epub 2018 Oct 18.

‟Carol Davila" University of Medicine and Pharmacy, Boulevard Eroii Sanitari, 8, Bucharest, Romania; National Institute for Infectious Diseases "Prof. Dr. Matei Balș", Dr. Calistrat Grozovici Street, 1, Bucharest, Romania. Electronic address:

Background: Malignancies have become a leading cause of morbidity and mortality in people living with HIV (PLHIV). The primary endpoint of our study was to describe the epidemiology of acquired immunodeficiency syndrome (AIDS)-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs). Epidemiological disparities, mortality predictors and survival analysis within the two groups of patients were key secondary endpoints. Read More

Radiographics 2018 Nov-Dec;38(7):2051-2068. Epub 2018 Oct 19.

From the Departments of Diagnostic Radiology (S.J., K.S., A.O., C.T.J., K.M.E.) and Interventional Radiology (N.K.), University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030; Department of Diagnostic Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.); Department of Radiology, University of Utah, Salt Lake City, Utah (A.S.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (M.G.L.); and Department of Radiology, University of Missouri Health Care, Columbia, Mo (A.H.G.).

The risk of developing malignancy is higher in patients with human immunodeficiency virus (HIV) infection than in non-HIV-infected patients. Several factors including immunosuppression, viral coinfection, and high-risk lifestyle choices lead to higher rates of cancer in the HIV-infected population. A subset of HIV-related malignancies are considered to be acquired immunodeficiency syndrome (AIDS)-defining malignancies, as their presence confirms the diagnosis of AIDS in an HIV-infected patient. Read More

Open Access Maced J Med Sci 2018 Sep 20;6(9):1688-1693. Epub 2018 Sep 20.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev Nr 79, Sofia, Bulgaria.

Background: Kaposi's sarcoma was first described in 1872 by Moritz Kaposi. To date, it is considered a malignant disease is originating from the endothelial cells of the lymphatic vessels believed to be infected with HHV-8. The current classification defines four major epidemiological forms of Kaposi's sarcoma: classical, endemic, AIDS-associated, and iatrogenic. Read More

Gerontology 2018 Oct 18:1-8. Epub 2018 Oct 18.

Division of Training and Movement Sciences, University of Potsdam, Potsdam, Germany.

Background: Dynamic balance keeps the vertical projection of the center of mass within the base of support while walking. Dynamic balance tests are used to predict the risks of falls and eventual falls. The psychometric properties of most dynamic balance tests are unsatisfactory and do not comprise an actual loss of balance while walking. Read More

J Natl Cancer Inst 2018 Oct 15. Epub 2018 Oct 15.

Los Angeles Cancer Surveillance Program, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Background: Cancer survival among adolescents and young adults (AYAs) was previously reported as showing little or no improvement compared to younger or older counterparts. The role of the HIV/AIDS epidemic in the AYA survival deficit has not been evaluated.

Methods: Using cancer registry data from the Surveillance, Epidemiology, and End Results program (SEER 9), we examined sex-specific 5-year relative survival trends for children (0-14 years old), AYAs (15-39 years old), and older adults (40 years and older) diagnosed with cancer during 1973-2009 and followed through the end of 2014. Read More

J Med Virol 2018 Oct 14. Epub 2018 Oct 14.

Department of Laboratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Background And Purpose: Kaposi's sarcoma-associated herpes virus (KSHV) vIL-6 is sufficient to induce lymphatic reprogramming of vascular endothelial cells, which is a key event in Kaposi's sarcoma (KS) development. This study was aimed to investigate the effect of Chinese herb oroxylin A on lymphatic reprogramming and neovascularization by KSHV vIL-6 in vitro and in vivo.

Methods: The lymphatic-phenotype endothelial cell line was generated by lentiviral KSHV vIL-6 infection. Read More

Rev Med Interne 2018 Dec 10;39(12):942-945. Epub 2018 Oct 10.

Service de Néphrologie, de dialyse et de transplantation rénale, CHU La Rabta, Tunis, Tunisie; Faculté de Médecine de Tunis, Université Tunis El Manar, Tunis, Tunisie.

Introduction: Iatrogenic Kaposi's sarcoma is widely reported after transplantation. Less commonly, it occurs in patients receiving immunosuppressive therapy for ANCA associated vasculitis. We report here the rare association of Kaposi's sarcoma, prurigo nodularis and ANCA associated vasculitis in a hemodialysis patient. Read More

Medicine (Baltimore) 2018 Oct;97(41):e12530

Department of Radiology.

Rationale: Kaposi's sarcoma (KS) is the most common malignant tumor in HIV-infected people and occurs mainly in the skin, mucous membranes, and lymph nodes. Approximately 33% of the initial skin manifestations of AIDS and approximately 35% to 79% of KS occur during disease progression. Otherwise, AIDS-related facial KS that was simultaneously examined by magnetic resonance imaging (MRI) is rare. Read More

Skin Res Technol 2018 Oct 12. Epub 2018 Oct 12.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.

Background: Intralesional vincristine is an effective treatment for Kaposi's sarcoma (KS) nodules on the skin, but there is little evidence of its action through imaging techniques. Ultrasonography can be an adjunctive tool in the diagnosis and management of KS skin lesions, but data in the literature are few.

Materials And Methods: Five patients with classic KS nodules were treated with intralesional vincristine. Read More

Clin Radiol 2018 Dec 9;73(12):1060.e1-1060.e7. Epub 2018 Oct 9.

Department of Radiology, Semmelweis University, Budapest, Hungary. Electronic address:

Aim: To evaluate the prognostic value of pretreatment pelvic magnetic resonance imaging (MRI) features in uterine artery embolisation (UAE) for symptomatic fibroids.

Materials And Methods: MRI characteristics of 109 fibroids (≥3 cm) in 70 patients were analysed retrospectively. Imaging was performed 1. Read More

J Virol 2019 Jan 10;93(1). Epub 2018 Dec 10.

Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA

In the beta- and gammaherpesviruses, a specialized complex of viral transcriptional activators (vTAs) coordinate to direct expression of virus-encoded late genes, which are critical for viral assembly and whose transcription initiates only after the onset of viral DNA replication. The vTAs in Kaposi's sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24, ORF30, ORF31, ORF34, and ORF66. While the general organization of the vTA complex has been mapped, the individual roles of these proteins and how they coordinate to activate late gene promoters remain largely unknown. Read More

Med Sci Sports Exerc 2018 Oct 9. Epub 2018 Oct 9.

University of Groningen, University Medical Center Groningen, The Netherlands.

Introduction: Parkinson's disease (PD) is a progressive neurodegenerative condition and it is unclear if long-term non-pharmaceutical interventions can slow the progression of motor and non-motor symptoms and lower drug dose.

Methods: In a randomized trial, after an initial 3-week-long, 15-session supervised high-intensity sensorimotor agility exercise (E) program designed to improve postural instability, the Exercise+Maintenance (E+M, n=19) group continued to exercise three times per week for 2 years, while E (n=16) and the no exercise and no maintenance control (C, n=20) continued habitual living. Eight outcomes were measured before and after the 3-week initial exercise program and then at 3, 6, 9, 12, 18, and 24 months in all patients. Read More