11,433 results match your criteria Kaposi Sarcoma


Kaposi's Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient.

Eur J Case Rep Intern Med 2016 19;3(7):000493. Epub 2016 Sep 19.

Department of Internal Medicine, Rabta Hospital, Tunis, Tunisia.

Introduction: Kaposi's sarcoma (KS) is an angioproliferative disorder first described in 1872 by Moritz Kaposi. Four main clinical presentations of KS have been described: classic, endemic, iatrogenic and epidemic. KS involvement of the lymph nodes is extremely uncommon in the classical variant form, especially if it precedes the skin manifestations. Read More

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http://dx.doi.org/10.12890/2016_000493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346768PMC
September 2016

Safety and Efficacy of Immune Checkpoint Inhibitor Therapy in Patients With HIV Infection and Advanced-Stage Cancer: A Systematic Review.

JAMA Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Medicine, Georgetown University, Washington, DC.

Importance: Patients with HIV infection are at increased risk for cancer. Cancer is the leading cause of death among non-AIDS-defining illnesses in these patients. Immune checkpoint inhibitor (ICI) therapy has transformed the treatment of cancer. Read More

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http://dx.doi.org/10.1001/jamaoncol.2018.6737DOI Listing
February 2019
1 Read

Extracellular vesicles from Kaposi Sarcoma-associated herpesvirus lymphoma induce long-term endothelial cell reprogramming.

PLoS Pathog 2019 Feb 4;15(2):e1007536. Epub 2019 Feb 4.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Extracellular signaling is a mechanism that higher eukaryotes have evolved to facilitate organismal homeostasis. Recent years have seen an emerging interest in the role of secreted microvesicles, termed extracellular vesicles (EV) or exosomes in this signaling network. EV contents can be modified by the cell in response to stimuli, allowing them to relay information to neighboring cells, influencing their physiology. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361468PMC
February 2019

Pomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells.

Oncoimmunology 2019 5;8(2):e1546544. Epub 2018 Dec 5.

HIV & AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Most chronic viruses evade T-cell and natural killer (NK) immunity through downregulation of immune surface markers. Previously we showed that Pomalidomide (Pom) increases surface expression of major histocompatibility complex class I (MHC-I) in Kaposi sarcoma-associated herpesvirus-infected latent and lytic cells and restores ICAM-1 and B7-2 in latent cells. We explored the ability of Pom to increase immune surface marker expression in cells infected by other chronic viruses, including human T-cell leukemia virus type-1 (HTLV-1), Epstein-Barr virus (EBV), human papilloma virus (HPV), Merkel cell polyoma virus (MCV), and human immunodeficiency virus type-1 (HIV-1). Read More

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1546544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343774PMC
December 2018
2 Reads

Kaposi Sarcoma Masquerading as a Tooth Abscess in a Patient With Human Immunodeficiency Virus.

Mayo Clin Proc 2019 Feb;94(2):370

Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1016/j.mayocp.2018.12.002DOI Listing
February 2019
6.262 Impact Factor

Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia.

Br J Haematol 2019 Jan 31. Epub 2019 Jan 31.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (24·58 for in situ and 7·63 for invasive), Merkel cell carcinoma (14·36), Hodgkin lymphoma (7·16) and Kaposi sarcoma (6·76). Read More

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http://dx.doi.org/10.1111/bjh.15777DOI Listing
January 2019
1 Read

Kaposi sarcoma.

Nat Rev Dis Primers 2019 Jan 31;5(1). Epub 2019 Jan 31.

Leidos Biomedical Research, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Kaposi sarcoma (KS) gained public attention as an AIDS-defining malignancy; its appearance on the skin was a highly stigmatizing sign of HIV infection during the height of the AIDS epidemic. The widespread introduction of effective antiretrovirals to control HIV by restoring immunocompetence reduced the prevalence of AIDS-related KS, although KS does occur in individuals with well-controlled HIV infection. KS also presents in individuals without HIV infection in older men (classic KS), in sub-Saharan Africa (endemic KS) and in transplant recipients (iatrogenic KS). Read More

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http://dx.doi.org/10.1038/s41572-019-0060-9DOI Listing
January 2019

Kaposi sarcoma.

Authors:

Nat Rev Dis Primers 2019 Jan 31;5(1):10. Epub 2019 Jan 31.

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http://dx.doi.org/10.1038/s41572-019-0065-4DOI Listing
January 2019

Comment on: 'Treatment of psoriasis with ustekinumab in a patient with HIV-related Kaposi sarcoma'.

Clin Exp Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Unit of Dermatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

We read with great interest the recent article by Wang et al. reporting on a psoriatic patient co-affected by HIV-related Kaposi's sarcoma (KS), whose poorly controlled psoriasis was successfully treated with ustekinumab, a fully monoclonal antibody that targets the common p40 subunit shared by interleukins (IL)-12 and IL-23. Interestingly, despite the evidences supporting the role of IL-12 in inhibiting tumorigenesis, the authors reported no KS progression after a 16-month follow-up. Read More

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http://dx.doi.org/10.1111/ced.13935DOI Listing
January 2019
3 Reads

Evaluation of dental students' knowledge and patient care towards HIV/ AIDS individuals.

Eur J Dent Educ 2019 Jan 25. Epub 2019 Jan 25.

School of Dentistry.

Purpose: The aim was to evaluate the knowledge of the students of dental students regarding patients care towards HIV positive individuals.

Methods: 283 dental students (pre-clinical, n = 45; clinical, n = 238) answered an electronic questionnaire, approaching biosafety procedures, oral manifestations of AIDS, and knowledge of HIV infection. Data were present as an average from findings from students of 9 different semesters, grouping them by pre-clinical (1-4) and clinical (5-9) semesters, from two different university campuses. Read More

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http://dx.doi.org/10.1111/eje.12423DOI Listing
January 2019
8 Reads

Human immunodeficiency virus-negative multicentric Castleman's disease coexistent with Kaposi's sarcoma on F-FDG PET/CT: A case report.

Mol Clin Oncol 2019 Feb 11;10(2):318-320. Epub 2018 Dec 11.

Department of Nuclear Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Gyeonggi 420-767, Republic of Korea.

Multicentric Castleman's disease and Kaposi's sarcoma are more frequently observed in human immunodeficiency virus (HIV)-infected patients; however, 40-50% of the cases are HIV-negative. The present study reports the case of a 61-year-old man who presented with palpable masses in the axillary and right inguinal areas. The blood test results revealed increased serum erythrocyte sedimentation rate and C-reactive protein level, with negative serological markers, including for HIV. Read More

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http://dx.doi.org/10.3892/mco.2018.1789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327215PMC
February 2019
4 Reads

Acquired immune deficiency syndrome-related epidemic Kaposi sarcoma.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

The Ronald O. Perleman Department of Dermatology, New York University Langone Health, New York, New York.

Kaposi sarcoma (KS) is a vascular neoplasm that is one of the most common human immunodeficiency virus (HIV)-related malignancies. We present the case of a 42-year-old man with a new diagnosis of HIV and acquired immune deficiency syndrome (AIDS)-related epidemic KS. Read More

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December 2018

Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome-associated Kaposi's sarcoma.

Exp Ther Med 2019 Jan 8;17(1):27-34. Epub 2018 Nov 8.

Department of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.

The present study investigated the expression of Toll-like receptor 4 (TLR4) and proteins involved in its associated signaling pathways in patients with classic Kaposi's sarcoma (KS) and acquired immune deficiency syndrome (AIDS)-associated KS (AIDS-KS) in Xinjiang Autonomous Region of China. A total of 35 patients with KS were enrolled in the present study between May 2011 and July 2013, including 26 cases of AIDS-KS and 9 cases of classic KS. Another 10 healthy subjects of the Uygur ethnic group were included in the normal control group. Read More

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http://dx.doi.org/10.3892/etm.2018.6941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307526PMC
January 2019
3 Reads

Immunodeficiencies that predispose to pathologies by human oncogenic γ-herpesviruses.

FEMS Microbiol Rev 2019 Jan 15. Epub 2019 Jan 15.

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.

Human γ-herpesviruses include the closely related tumor viruses Epstein Barr virus (EBV) and Kaposi Sarcoma-associated herpesvirus (KSHV). EBV is the most growth transforming pathogen known and linked to at least seven human malignancies. KSHV is also associated with three human cancers. Read More

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https://academic.oup.com/femsre/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/femsre/fuy044DOI Listing
January 2019
3 Reads

Evaluating the use of pathology in improving diagnosis in rural Malawi.

Malawi Med J 2018 09;30(3):162-166

Partners In Health, Neno, Malawi.

Introduction: Limited data exists on histologically confirmed cancers and tuberculosis in rural Malawi, despite the high burden of both conditions. One of the main reasons for the limited data is the lack of access to pathology services for diagnosis. We reviewed histopathology results of patients in Neno District, one of the poorest rural districts in Malawi, from May 2011 to July 2017, with an emphasis on cancers and tuberculosis. Read More

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https://www.ajol.info/index.php/mmj/article/view/180027
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http://dx.doi.org/10.4314/mmj.v30i3.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307059PMC
September 2018
3 Reads
0.191 Impact Factor

Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral IL-6 (vIL-6) Enhances Immunoglobulin Class-Switch Recombination.

Front Microbiol 2018 18;9:3119. Epub 2018 Dec 18.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States.

Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic gamma-herpesvirus that causes AIDS-associated Kaposi sarcoma (KS) and several lymphoproliferative disorders. During the humoral immune response antigen-activated mature B cells acquire functional diversification by immunoglobulin heavy chain (IgH) class-switch recombination (CSR). CSR is initiated by activation-induced cytidine deaminase (AID) which targets highly repetitive switch (S)-regions to mediate DNA double-stranded breaks (DSBs) in the IgH locus facilitating intramolecular recombination. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305588PMC
December 2018

Decreased incidence of Kaposi sarcoma after kidney transplant in Italy and role of mTOR-inhibitors: 1997-2016.

Int J Cancer 2019 Jan 6. Epub 2019 Jan 6.

Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano (PN), Italy.

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http://dx.doi.org/10.1002/ijc.32098DOI Listing
January 2019

Multiple remissions of extracavitary primary effusion lymphoma treated with a single cycle of liposomal doxorubicin in a patient infected with HIV.

Curr Oncol 2018 Dec 1;25(6):e592-e596. Epub 2018 Dec 1.

Chronic Viral Illness Service, McGill University Health Centre, Montreal, QC.

Primary effusion lymphoma (pel) is a rare human herpesvirus 8 (hhv8)-related large B cell lymphoma with plasmablastic, immunoblastic, or anaplastic features that often carries a poor prognosis. This lymphoma occurs mainly in patients with hiv infection, most often with Epstein-Barr virus (ebv) co-infection, and usually presents as body cavity effusions or, less commonly, as extracavitary lesions without effusion (ec-pel). Chemotherapeutic treatment options are limited and require concurrent antiretroviral therapy (art). Read More

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http://dx.doi.org/10.3747/co.25.4119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291272PMC
December 2018
3 Reads

[Replication Machinery of Kaposi's Sarcoma-associated Herpesvirus and Drug Discovery Research].

Yakugaku Zasshi 2019 ;139(1):69-73

Department of Cell Biology, Kyoto Pharmaceutical University.

Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Castleman's disease. While liposomal doxorubicin has been used as an effective treatment for KS patients, the cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen used for PEL patients was reported to have 1-year survival rates of less than 40%. Moreover, the development of anti-KSHV drugs inhibiting viral replication has been delayed. Read More

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http://dx.doi.org/10.1248/yakushi.18-00164-2DOI Listing
January 2019

Oral Kaposi Sarcoma.

JAMA Dermatol 2019 Jan 2. Epub 2019 Jan 2.

Department of Dermatology, University of Illinois at Chicago College of Medicine, Chicago.

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http://dx.doi.org/10.1001/jamadermatol.2018.4079DOI Listing
January 2019

Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study.

J Pediatr Hematol Oncol 2018 Dec 27. Epub 2018 Dec 27.

Kilimanjaro Christian Medical University College.

Objective: We aimed to establish the prevalence of human immunodeficiency virus (HIV)-associated malignancies in children attending a care and treatment clinic at Kilimanjaro Christian Medical Centre.

Materials And Methods: This was a retrospective cross-sectional hospital-based study of children who attended an HIV care and treatment clinic between 2006 and 2014. Children aged 2 months to 17 years were eligible for participation. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001389DOI Listing
December 2018
1 Read

Safety and efficacy of an oncolytic viral strategy using bortezomib with ICE/R in relapsed/refractory HIV-positive lymphomas.

Blood Adv 2018 Dec;2(24):3618-3626

Moores Cancer Center, University of California, San Diego, La Jolla, CA.

HIV-associated lymphomas (HALs) have high rates of latent infection by gammaherpesviruses (GHVs). We hypothesized that proteasome inhibition would induce lytic activation of GHVs and inhibit HIV infectivity via preservation of cytidine deaminase APOBEC3G, improving lymphoma control. We tested this oncolytic and antiviral strategy by using bortezomib combined with ifosfamide, carboplatin, and etoposide (ICE) alone or with rituximab (ICE/R) in relapsed/refractory HAL. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018022095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306883PMC
December 2018
1 Read

Quantitative RNAseq analysis of Ugandan KS tumors reveals KSHV gene expression dominated by transcription from the LTd downstream latency promoter.

PLoS Pathog 2018 12 17;14(12):e1007441. Epub 2018 Dec 17.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

KSHV is endemic in Uganda and the HIV epidemic has dramatically increased the incidence of Kaposi sarcoma (KS). To investigate the role of KSHV in the development of KS, we obtained KS biopsies from ART-naïve, HIV-positive individuals in Uganda and analyzed the tumors using RNAseq to globally characterize the KSHV transcriptome. Phylogenetic analysis of ORF75 sequences from 23 tumors revealed 6 distinct genetic clusters with KSHV strains exhibiting M, N or P alleles. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312348PMC
December 2018

KSHV co-infection, a new co-factor for HPV-related cervical carcinogenesis?

Am J Cancer Res 2018 1;8(11):2176-2184. Epub 2018 Nov 1.

Department of Genetics, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center 1700 Tulane Ave, New Orleans, LA 70112, USA.

High-risk human papillomavirus (HPV) infection is the etiological agent of cervical cancer and some other cancers. Kaposi sarcoma-associated herpesvirus (KSHV) represents a principal causative agent of several human cancers arising in those immunocompromised patients. In fact, KSHV DNA has been detected in the female genital tract, and this virus may share some transmission routes with HPV, although the detection rate of KSHV in cervical samples is very low and the KSHV/HPV co-infection is seldom reported. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291645PMC
November 2018

Letter to the editors regarding the paper: Prognostic factors in HIV-positive patients with non-Hodgkin lymphoma: a Peruvian experience.

Infect Agent Cancer 2018 11;13:39. Epub 2018 Dec 11.

1Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, 2 Alameda San Marcos Avenue, Chorrillos, 15067 Lima, Peru.

Non-Hodgkin Lymphoma (NHL) is a neoplasm associated with a group of malignancies called AIDs-Defining Malignancies (ADMs) in Human-Immunodeficiency Virus (HIV) -patients. Similar to the case of NHL in Latin America, particularly in Peru, the amount of research done on others ADMs is limited, especially in the case of Kaposi's Sarcoma (KS). Prior investigations have talked about the great potential risk that represents this illness in latin american population, but topics as prognosis factors are yet to be well defined. Read More

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http://dx.doi.org/10.1186/s13027-018-0213-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288895PMC
December 2018
1 Read

Regression of human immunodeficiency virus-associated oral Kaposi sarcoma with combined antiretroviral therapy: A case report and literature review.

Head Neck 2019 Feb 15;41(2):E21-E25. Epub 2018 Dec 15.

Oral Pathology, Department of Stomatology, University of Sao Paulo School of Dentistry, Sao Paulo, Brazil.

Background: Kaposi's sarcoma (KS) is the most prevalent malignant neoplasia in human immunodeficiency virus positive (HIV+) patients for which the primary mode of management was chemotherapy.

Methods: We have presented the case of a newly diagnosed HIV+ male patient who was diagnosed with a pedunculated nodule in the anterior region of the hard palate, measuring 3.5 cm in diameter and with 2 months of evolution. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25446
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http://dx.doi.org/10.1002/hed.25446DOI Listing
February 2019
5 Reads

[External auditory canal HIV-associated Kaposi sarcoma: a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1910-1911

External auditory canal HIV-associated Kaposi sarcoma is rare. A 47-year-old male patient found a lump locked in the right external auditory canal gradually enlarging during the 4 months. Preoperative examination suggested that the patient had infected with HIV. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.24.016DOI Listing
December 2018

Letter to the Editor: Could Immunogenicity of Kaposi Sarcoma Be More Linked to Viral Antigens Than to the Tumor Mutational Burden?

J Natl Compr Canc Netw 2018 12;16(12):1418-1419

Hôpital Saint-Louis, Paris Diderot University, Paris, France.

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http://dx.doi.org/10.6004/jnccn.2018.7088DOI Listing
December 2018

AIDS-Associated Malignancies.

Cancer Treat Res 2019 ;177:1-21

Department of Dermatology, University of Texas Health Sciences Center at Houston, Houston, TX, 77030, USA.

Malignancies were one of the earliest recognized manifestations that led to the description of the acquired immune deficiency syndrome (AIDS). The majority of cancers in AIDS patients are associated with coinfection with oncogenic viruses, such as Epstein-Barr virus, human herpesvirus 8, and human papillomavirus, with resulting malignancies occurring secondary to diminished immune surveillance against viruses and virus-infected tumor cells. Over 50% of AIDS lymphomas are associated with Epstein-Barr virus (EBV) and/or HHV8 infection. Read More

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http://dx.doi.org/10.1007/978-3-030-03502-0_1DOI Listing
January 2019
6 Reads

Extensive Kaposi sarcoma infiltration in bone marrow in a patient with HIV.

Blood 2018 Dec;132(23):2525

The University of Texas MD Anderson Cancer Center.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-09
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http://dx.doi.org/10.1182/blood-2018-09-872994DOI Listing
December 2018
6 Reads

Cancer incidence in Northern Uganda (2013-2016).

Int J Cancer 2018 Dec 10. Epub 2018 Dec 10.

African Cancer Registry Network, Oxford, United Kingdom.

Gulu Cancer Registry was established in 2014 to assess the incidence and survival of cancer in 4 districts of the Acholi Sub-region of northern Uganda. Here we report the results of the first 4 years of registration (2013-2016) in this largely rural population of 771,514. In total there were 1627 cases of cancers registered; 644 among men (corresponding to an ASR of 106. Read More

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http://dx.doi.org/10.1002/ijc.32053DOI Listing
December 2018
3 Reads

Malignant Vascular Tumors of the Liver in Adults.

Semin Liver Dis 2019 Feb 7;39(1):1-12. Epub 2018 Dec 7.

Department of Radiology, BCLC Group, Hospital Clinic Barcelona, University of Barcelona, Barcelona, Catalonia-Spain.

Hepatic angiosarcoma and epithelioid hemangioendothelioma (EHE) might be clinically considered a spectrum since, although more frequently presenting indolent behavior, EHE occasionally evolves to high-grade neoplasms. However, in most circumstances, pathological and immunohistochemical patterns define this differential diagnosis. More recently, molecular pathways for angiosarcoma and for EHE from other organs and from soft tissue have been proved different, paving the way for future morpho-molecular assessment of their hepatic counterpart. Read More

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http://dx.doi.org/10.1055/s-0038-1676120DOI Listing
February 2019
2 Reads

Gastrointestinal Kaposi sarcoma.

Indian J Gastroenterol 2018 Nov;37(6):567-568

Division of Gastroenterology, Lenox Hill Hospital, New York, NY, USA.

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http://dx.doi.org/10.1007/s12664-018-0918-xDOI Listing
November 2018

Polymorphisms in KSHV-encoded microRNA sequences affect levels of mature viral microRNA in Kaposi Sarcoma lesions.

Oncotarget 2018 11 9;9(88):35856-35869. Epub 2018 Nov 9.

AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Background: We previously reported Kaposi sarcoma-associated herpesvirus (KSHV) microRNA sequence variants in clinical samples correlated with increased risk of multicentric Castleman's disease (MCD). We then demonstrated that microRNAs with variant sequence have different maturation and mature microRNA expression . Here, we illustrate the association between microRNA sequence and changes in mature microRNA levels within Kaposi sarcoma (KS) lesions. Read More

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http://dx.doi.org/10.18632/oncotarget.26321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254685PMC
November 2018
13 Reads
6.359 Impact Factor

Brief Report: Malignancies in Adults Living With HIV in Asia.

J Acquir Immune Defic Syndr 2019 Mar;80(3):301-307

Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Hematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence of, risk factors for, and outcomes of hematological and nonhematological malignancies in PLHIV in Asia.

Methods: Incidence of malignancy after cohort enrollment was evaluated. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375805PMC
March 2019
3 Reads
4.556 Impact Factor

African Kaposi's Sarcoma.

Acta Med Port 2018 Nov 30;31(11):697. Epub 2018 Nov 30.

Department of Dermatology. Santa Maria University Hospital. Lisbon. Institute for Hygiene and Tropical Medicine. Universidade NOVA. Lisbon. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

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http://dx.doi.org/10.20344/amp.9754DOI Listing
November 2018
5 Reads

Ribonucleotide Reductase Inhibitor 3-AP Induces Oncogenic Virus Infected Cell Death and Represses Tumor Growth.

J Cancer 2018 31;9(23):4503-4509. Epub 2018 Oct 31.

Department of Pediatrics, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human malignancies, particularly Kaposi's Sarcoma (KS), which preferentially arise in immunocompromised patients such as HIV+ subpopulation while still lacking of effective therapeutic options. We recently found that the ribonucleotide reductase (RR) subunit M2 is potentially regulated by the key oncogenic HGF/c-MET pathway in KSHV-related lymphoma cells. One of RR inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) effectively induced apoptosis of KSHV+ lymphomas and suppressed tumor progression . Read More

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http://dx.doi.org/10.7150/jca.27437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277659PMC
October 2018
1 Read

[Opportunistic infections: What's new?]

Dtsch Med Wochenschr 2018 Dec 3;143(24):1755-1758. Epub 2018 Dec 3.

Klinische Arbeitsgemeinschaft AIDS Deutschland (KAAD), Sektion der Deutschen AIDS-Gesellschaft (DAIG).

Guidelines from 3 clinical societies and peer-reviewed publications have been reviewed for recent changes in the management of opportunistic infections. Trimethoprim and sulfamethoxazol administered intravenously is an option to treat cerebral toxoplasmosis if oral therapy is not feasible. CD4 T cell cut-off for starting prophylaxis with trimethoprim and sulfamethoxazole is now 200/µl. Read More

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http://dx.doi.org/10.1055/a-0641-9456DOI Listing
December 2018
3 Reads

Palmoplantar lymphangioma-like Kaposi sarcoma.

J Dtsch Dermatol Ges 2019 Feb 3;17(2):192-194. Epub 2018 Dec 3.

Servicio de Dermatología, Hospital de Cabueñes, Gijón, Asturias, Spain.

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http://dx.doi.org/10.1111/ddg.13709DOI Listing
February 2019

Human Oncoviruses: Mucocutaneous Manifestations, Pathogenesis, Therapeutics, and Prevention (Part II: Hepatitis Viruses, Human T-cell Leukemia Viruses, Herpesviruses, and Epstein-Barr Virus).

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.10.072DOI Listing
November 2018
5 Reads

Nanomedicine for cutaneous tumors - lessons since the successful treatment of the Kaposi sarcoma.

Nanomedicine (Lond) 2018 Nov 30. Epub 2018 Nov 30.

Genetics & Morphology Department, Institute of Biological Science, University of Brasilia, Brasília DF 70910-900, Brazil.

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http://dx.doi.org/10.2217/nnm-2018-0374DOI Listing
November 2018

Cutaneous Sarcomas.

Hematol Oncol Clin North Am 2019 Feb;33(1):87-101

Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA; Cutaneous Oncology Program, Dana Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

Cutaneous sarcomas are rare malignancies that may present with a variety of clinical manifestations. This article focuses on 4 of the most common cutaneous sarcomas (Kaposi sarcoma, cutaneous angiosarcoma, dermatofibrosarcoma protuberans, and cutaneous leiomyosarcoma) and reviews clinical, diagnostic, and therapeutic aspects of these rare skin malignancies. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.08.007DOI Listing
February 2019
1 Read

Primary Gastrointestinal Kaposi's Sarcoma in a Patient with Human Immunodeficiency Virus.

Case Rep Oncol 2018 Sep-Dec;11(3):638-647. Epub 2018 Oct 22.

Internship in Medicine, Fundacion Universitaria Sanitas, Bogotá, Colombia.

Gastrointestinal bleeding in HIV patients secondary to coinfection by HHV8 and development of Kaposi's sarcoma (KS) is a rare complication even if no skin lesions are detected on physical examination. This article indicates which patients might develop this type of clinical sign and also tries to recall that absence of skin lesions never rules out the presence of KS, especially if gastrointestinal involvement is documented. Gastrointestinal bleeding in terms of hematemesis has rarely been reported in the literature. Read More

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http://dx.doi.org/10.1159/000492715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244015PMC
October 2018
9 Reads

Acroangiodermatitis of Mali (Pseudo-Kaposi Sarcoma) Associated with Chronic Venous Insufficiency and Obesity: A Case Report.

Wounds 2018 Nov;30(11):E105-E107

College of Medicine, Taif University, Taif, Saudi Arabia.

Introduction: Acroangiodermatitis, also known as psesudo-Kapsoi sarcoma, is a rare and benign angioproliferative malady. It presents clinically as purple-colored plaques, patches, or nodules resembling Kaposi sarcoma and is often related to chronic venous insufficiency, arteriovenous malformation of the legs, paralyzed limbs, and residual limbs. Obesity is a risk factor for venous insufficiency and could be related to acroangiodermatitis. Read More

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November 2018
16 Reads

Endemic Kaposi sarcoma in HIV-negative children and adolescents: an evaluation of overlapping and distinct clinical features in comparison with HIV-related disease.

Infect Agent Cancer 2018 9;13:33. Epub 2018 Nov 9.

Baylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.

Background: Endemic Kaposi sarcoma (KS) was first described in African children over fifty years ago, but has recently been overshadowed by HIV-related disease. We aimed to evaluate the similarities and differences between endemic HIV-negative and epidemic HIV-positive pediatric KS in a KS-associated herpesvirus-endemic region of Africa.

Methods: We describe clinical characteristics of 20 HIV-negative children with endemic KS over a six-year period and compare findings with a historical control-an HIV-related pediatric KS cohort from Lilongwe, Malawi. Read More

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https://infectagentscancer.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13027-018-0207-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230225PMC
November 2018
10 Reads
2.071 Impact Factor

Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.

Proc Natl Acad Sci U S A 2018 12 19;115(50):12805-12810. Epub 2018 Nov 19.

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

Noncoding RNAs have substantial effects in host-virus interactions. Circular RNAs (circRNAs) are novel single-stranded noncoding RNAs which can decoy other RNAs or RNA-binding proteins to inhibit their functions. The role of circRNAs is largely unknown in the context of Kaposi's sarcoma herpesvirus (KSHV). Read More

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http://dx.doi.org/10.1073/pnas.1816183115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294913PMC
December 2018
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High Cancer Burden Among Antiretroviral Therapy Users in Malawi: a Record Linkage Study of Observational HIV Cohorts and Cancer Registry Data.

Clin Infect Dis 2018 Nov 17. Epub 2018 Nov 17.

Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Background: With antiretroviral therapy (ART), AIDS-defining cancer incidence has declined and non-AIDS defining cancers are now more frequent among HIV-infected populations in high-income countries. In sub-Saharan Africa, limited epidemiological data describe cancer burden among ART users.

Methods: We used probabilistic algorithms to link cases from the population-based cancer registry with electronic medical records supporting ART delivery in the Malawi's two largest HIV cohorts, Lighthouse Trust (LT; 2007-2010) and Queen Elizabeth Central Hospital (QECH; 2000-2010). Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciy960DOI Listing
November 2018
17 Reads
8.890 Impact Factor

Experimental co-transmission of Simian Immunodeficiency Virus (SIV) and the macaque homologs of the Kaposi Sarcoma-Associated Herpesvirus (KSHV) and Epstein-Barr Virus (EBV).

PLoS One 2018 16;13(11):e0205632. Epub 2018 Nov 16.

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.

Macaque RFHV and LCV are close homologs of human KSHV and EBV, respectively. No experimental model of RFHV has been developed due to the lack of a source of culturable infectious virus. Screening of macaques at the Washington National Primate Research Center detected RFHV in saliva of SIV-infected macaques from previous vaccine studies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205632PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239284PMC
November 2018
10 Reads

Epstein-Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus.

Proc Natl Acad Sci U S A 2018 11 14;115(48):E11379-E11387. Epub 2018 Nov 14.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC 27599

Primary effusion lymphoma (PEL) is a B cell lymphoma that is always associated with Kaposi's sarcoma-associated herpesvirus (KSHV) and in many cases also with Epstein-Barr virus (EBV); however, the requirement for EBV coinfection is not clear. Here, we demonstrate that adding exogenous EBV to KSHV single-positive PEL leads to increased KSHV genome maintenance and KSHV latency-associated nuclear antigen (LANA) expression. To show that EBV was necessary for naturally coinfected PEL, we nucleofected KSHV/EBV PEL cell lines with an EBV-specific CRISPR/Cas9 plasmid to delete EBV and observed a dramatic decrease in cell viability, KSHV genome copy number, and LANA expression. Read More

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http://dx.doi.org/10.1073/pnas.1810128115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275488PMC
November 2018
10 Reads