Search Our Scientific Publications & Authors

mBio 2020 Aug 4;11(4). Epub 2020 Aug 4.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Stimulator of interferon genes (STING) is an essential adaptor protein of the innate DNA-sensing signaling pathway, which recognizes genomic DNA from invading pathogens to establish antiviral responses in host cells. STING activity is tightly regulated by several posttranslational modifications, including phosphorylation. However, specifically how the phosphorylation status of STING is modulated by kinases and phosphatases remains to be fully elucidated. Read More

Int J STD AIDS 2020 Aug 4:956462420943027. Epub 2020 Aug 4.

Infectious Diseases Department, Instituto Nacional de Cancerología, Ciudad de México, Mexico.

We present the case of a 28-year-old man with recently-diagnosed human immunodeficiency virus and hepatitis C virus infection. He developed obstructive cholangiopathy secondary to cytomegalovirus and Kaposi sarcoma, both diagnosed by endoscopic retrograde cholangiopancreatography and biopsies. He received antiretroviral therapy, chemotherapy and valganciclovir with full recovery. Read More

An Bras Dermatol 2020 Jun 26. Epub 2020 Jun 26.

Dermatology Service, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil.

We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Read More

Cureus 2020 Jun 29;12(6):e8913. Epub 2020 Jun 29.

Gastroenterology and Hepatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

Kaposi sarcoma is one of the acquired immunodeficiency syndrome (AIDS) defining diseases. AIDS-associated Kaposi sarcoma affects primarily the skin and the lungs. Although gastrointestinal involvement is relatively common, biliary tract involvement has rarely been reported. Read More

Cureus 2020 Jun 23;12(6):e8784. Epub 2020 Jun 23.

Internal Medicine, Henry Ford Allegiance Health, Jackson, USA.

Kaposi sarcoma herpesvirus (KSHV) is associated with Kaposi sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease (KSHV-MCD) in patients infected with human immunodeficiency virus (HIV). We present a case consistent with a newly recognized KSHV inflammatory cytokine syndrome (KICS), distinct from KSHV-MCD. Although both disorders exhibit signs of substantial inflammation, KICS has minimal lymphadenopathy/splenomegaly and negative pathologic nodal changes in the setting of low CD4 count. Read More

J Dermatol 2020 Jul 28. Epub 2020 Jul 28.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Because primary skin cancers in organ transplant recipients are rare, little is known about the characteristics and risk factors for skin cancers in organ transplant recipients. We searched the Asan Medical Center database of 13 469 organ transplant recipients for cases of all skin cancers from January 1990 to December 2018. Characteristics of and risk factors for skin cancers were analyzed and compared according to the period of transplantation. Read More

Viruses 2020 Jul 23;12(8). Epub 2020 Jul 23.

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

A common biologic property of the gammaherpesviruses Epstein-Barr Virus and Kaposi sarcoma herpesvirus is their use of B lymphocytes as a reservoir of latency in healthy individuals that can undergo oncogenic transformation later in life. Gammaherpesviruses (GHVs) employ an impressive arsenal of proteins and non-coding RNAs to reprogram lymphocytes for proliferative expansion. Within lymphoid tissues, the germinal center (GC) reaction is a hub of B cell proliferation and death. Read More

Am J Ophthalmol Case Rep 2020 Sep 16;19:100832. Epub 2020 Jul 16.

MedStar Georgetown University Hospital, USA.

Purpose: To report a case of Kaposi sarcoma in a patient with previously undiagnosed Human Immunodeficiency Virus (HIV) infection.

Observations: A 23-year-old male patient presented to the eye clinic with complaints of redness of his left eye for the past month. The patient had been seen one day prior to presentation in the emergency department for a neck mass and pneumonia. Read More

Clin Infect Dis 2020 Jul 25. Epub 2020 Jul 25.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Background: Antiretroviral therapy has reduced mortality among people with HIV, but cancer remains an important cause of death. We characterized cancer-attributable mortality in the US HIV population during 2001-2015.

Methods: We utilized data from population-based HIV and cancer registries in the US. Read More

Skin Res Technol 2020 Jul 23. Epub 2020 Jul 23.

Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, Siena, Italy.

JCO Glob Oncol 2020 Jul;6:1134-1146

Center for Global Health, National Cancer Institute, Rockville, MD.

Purpose: The aim of this study was to review the current status of clinical trials for HIV-associated malignancies in people living with HIV in sub-Saharan Africa (SSA) and efforts made by the AIDS Malignancy Consortium (AMC) to build capacity in SSA for HIV malignancy research.

Methods: All malignancy-related clinical trials in 49 SSA countries on ClinicalTrials.gov were reviewed and evaluated for inclusion and exclusion criteria pertaining to HIV status. Read More

Clin Case Rep 2020 Jul 13;8(7):1134-1137. Epub 2020 Apr 13.

Skin Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.

First presentation of the Kaposi sarcoma (KS) on the penis is not prevalent, and it was reported in 2%-3% of the cases that mostly occurred in the HIV-positive patients. Here, we report a case of primary KS on the glans penis in an HIV-negative patient. Read More

Rom J Intern Med 2020 Jul 17. Epub 2020 Jul 17.

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Human herpesvirus 8, also known as Kaposi sarcoma-associated herpesvirus (KSHV), is one of the few pathogens recognized as direct carcinogen, being involved in the pathogenesis of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. KSHV is a relatively recently discovered virus, with still limited possibilities for diagnosis and treatment. Therefore, ongoing studies are trying to answer the main issues related to the management of KSHV infection and its associated diseases. Read More

SAGE Open Med Case Rep 2020 2;8:2050313X20938249. Epub 2020 Jul 2.

Hematology Oncology, The Brooklyn Hospital Center, New York, NY, USA.

Kaposi sarcoma is an uncommon tumor that primarily arises in the skin and mucosal surfaces, but may metastasize to the internal organs. Four main variants of Kaposi sarcoma are recognized as the following: classic Kaposi sarcoma, which occurs in middle-aged or elderly men; epidemic Kaposi sarcoma, associated with human immunodeficiency virus infection; iatrogenic Kaposi sarcoma seen in patients on immunosuppressive drug therapy; and endemic Kaposi sarcoma. This report is of a case of classic Kaposi sarcoma in 55-year-old immunocompetent and human immunodeficiency virus-negative Dominican man who had lived in the United States for 2 years, who presented with a 2-year history of skin lesions on his lower extremities and soft palate. Read More

Am J Transplant 2020 Jul 13. Epub 2020 Jul 13.

Montgomery Dermatology, Lankenau Institute for Medical Research, King of Prussia, PA, USA.

Organ transplant recipients (OTRs) are at increased risk of cutaneous malignancy. Skin disorders in OTRs of color (OTRoC) have rarely been systematically assessed. We aimed to ascertain the burden of skin disease encountered in OTRoC by prospectively collecting data from OTRs attending two post-transplant skin surveillance clinics: one in London, UK and one in Philadelphia, USA. Read More

Cannabis Cannabinoid Res 2020 Jun 5;5(2):121-131. Epub 2020 Jun 5.

Center for Research in Medical Pharmacology, University of Insubria, Varese, Italy.

The possibility of cannabidiol (CBD) to be used as an antiviral or to treat viral diseases has received limited attention so far, despite the growing number of claims that CBD could be used for the treatment of viral infection-related conditions. Therefore, we systematically retrieved and critically evaluated the scientific literature available on PubMed and the claims on the Internet, to assess the current state of knowledge on the use of CBD in viral diseases, and to provide suggestions for future research directions. PubMed search referenced two original articles supporting the use of CBD for the treatment of hepatitis C and Kaposi sarcoma and one article reporting the ability of CBD to reduce neuroinflammation in a virus-induced animal model of multiple sclerosis. Read More

Cureus 2020 Jun 8;12(6):e8502. Epub 2020 Jun 8.

Internal Medicine, Methodist Health System, Dallas, USA.

Kaposi's sarcoma (KS) is a cancer that often affects individuals with human immunodeficiency virus, acquired immunodeficiency syndrome (AIDS), those who have received an organ transplant, or others who are immunocompromised. KS is a vascular tumor that most often presents in cutaneous sites, including the lower extremities, oral mucosa, and genitalia. Literature regarding KS with ocular involvement is scarce. Read More

Clin Transplant 2020 Jul 12:e14041. Epub 2020 Jul 12.

Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, USA.

There are only scattered case reports documenting belatacept use in HIV+ kidney transplant recipients. We performed a retrospective review to describe short-term outcomes following conversion to belatacept in a cohort of HIV+ patients. Patients were included if they were converted to belatacept between May 2015-May 2019, had an HIV- donor, and received ≥ 4 doses of belatacept. Read More

J Med Virol 2020 Jul 10. Epub 2020 Jul 10.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.

Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human cancers, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), which are mostly seen in immunocompromised patients such as HIV+ individuals. Tuberculosis (TB), caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb), remains one of the deadliest infectious diseases in the world. The risk of developing TB is dramatically higher in people living with HIV than among those without HIV infection. Read More

J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(2):2309499020915989

Department of Orthopedic Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, China.

Purpose: Evidence on the incidence, prevalence, and outcomes of bone metastases among patients with systemic malignancy is limited. This study aimed to evaluate it using the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: We collected patients diagnosed with solid malignant tumors deriving outside of the bone, hematologic malignancies, Kaposi sarcoma, lymphoma, and myeloma from the SEER database (from 2010 to 2013). Read More

Arch Esp Urol 2020 Jul;73(6):570-571

Servicio de Anatomía Patológica. Complejo Hospitalario Universitario de Ferrol. Área Sanitaria de Ferrol. SERGAS. Ferrol. A Coruña. España.

53 year old renal transplanted male with secondary amyloidosis to Crohn´sdisease, sent to Dermatology given the presence of multiple red-purple or hyperkeratotic... Read More

Am J Transplant 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

Kaposi sarcoma (KS) can develop following organ transplantation through reactivation of recipient human herpesvirus 8 (HHV-8) infection or through donor-derived HHV-8 transmission. We describe 6 cases of donor-derived HHV-8 infection and KS investigated from July 2018 to January 2020. Organs from 6 donors, retrospectively identified as HHV-8-positive, with a history of drug use disorder, were transplanted into 22 recipients. Read More

Epidemiol Prev 2020 Mar-Jun;44(2-3):128-136

Mantova Cancer Registry, Epidemilogy Unit, Agenzia di Tutela della Salute (ATS) della Val Padana, Mantova (Italy).

Background: exposure to dioxins has been associated with an increased risk of soft-tissue sarcoma (STS). In a study relating to 1989-1998, a significant excess of STS was found in the population living within a 2-kilometre radius of an industrial incinerator located inside a Mantua industrial site. In the years 1974-1991, the incinerator burned hazardous chlorine-containing waste that resulted in the emission of dioxins. Read More

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

The University of Texas MD Anderson Cancer Center, Houston, TX.

Kaposi sarcoma typically presents as violaceous macules and papules in immunocompromised, specifically HIV-positive, patients. Its distinct clinical features often facilitate rapid diagnosis. In this article, we report a case of Kaposi sarcoma presenting as a concerning yet nondescript lesion in an HIV-negative woman. Read More

JAAD Case Rep 2020 Jul 11;6(7):625-627. Epub 2020 May 11.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

Adv Exp Med Biol 2020 ;1263:45-54

Department of Radiology, Baylor College of Medicine, Houston, TX, USA.

Oncomodulatory viruses can affect the tumor microenvironment (TME) by triggering inflammation, suppressing apoptosis, initiating angiogenesis, altering tumor metabolism, and stimulating tumor cell signaling pathways, leading to tumor growth, proliferation, and invasion. The higher incidence of malignancies among people with HIV (PWH), despite the widespread use of antiretroviral therapy (ART), suggests a more complex relation than HIV-associated immune deregulation. Viral cooperation can have synergistic effect on tumorigenesis. Read More

Intern Med 2020 Jun 23. Epub 2020 Jun 23.

Division of Rheumatology, Department of Internal Medicine, Okinawa Chubu Hospital, Japan.

J Infect Dis 2020 Jun 19. Epub 2020 Jun 19.

Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, USA.

Recently we demonstrated that activated mast cells (MCs) are enriched in Kaposi sarcoma (KS) tumors and contribute to the inflammatory microenvironment. Mechanisms driving MC activation, however, are incompletely understood. We sought to understand whether Immunoglobulin E (IgE), a potent activator of MCs, was associated with KS incidence and severity. Read More

Skin Res Technol 2020 Jun 17. Epub 2020 Jun 17.

TOOsonix A/S, Horsholm, Denmark.

Background: Skin cancer is common, growing, challenging, and in need of progress in early-stage treatment. 20 MHz high-intensity focused ultrasound (HIFU) is new and applied to actinic keratosis (AK) and skin cancers for the first time. HIFU of lower frequency is already used in the treatment of internal cancers. Read More

Turk Gogus Kalp Damar Cerrahisi Derg 2019 Jun 22;28(2):382-385. Epub 2020 Apr 22.

Department of Pathology, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey.

Pseudo-Kaposi sarcoma is a rare, vasoproliferative skin disease usually caused by an underlying vascular malformation or venous insufficiency. Unusual forms such as amputation stumps and lower extremity paralysis have been also reported. However, its emergence in the leg from which the saphenous vein was harvested following peripheral artery disease and coronary artery bypass surgery has not been previously reported. Read More

G Ital Dermatol Venereol 2020 Jun 15. Epub 2020 Jun 15.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Australas J Dermatol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology, Hospital Universitario de Móstoles, Madrid, Spain.

Topical timolol has been shown to be effective on treatment of Kaposi sarcoma. We present the case of a 72-year-old man with classic Kaposi sarcoma on upper limbs, treated with topical timolol 0.5% twice a day with a pruritic eruption on areas of application. Read More

Curr HIV Res 2020 ;18(3):154-164

Faculty of Art and Science, Department of Biology, Harran University, Sanliurfa, Turkey.

Background: Emergence of Kaposi's Sarcoma in the cases other than HIV, following the use of immunosuppressant drugs, demonstrates that it is related to weak immunity. The fact that this malignancy does not occur in every HIV-positive patient suggests that genetic predisposition may also be effective. Replacement of one of the base pairs of adenine, guanine, cytosine, and thymine that constitute the DNA sequence in the human genome with another base pair can affect susceptibility to disease, response to treatment, and immunity. Read More

Urology 2020 Jun 9. Epub 2020 Jun 9.

The Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address:

Case Report: A 65-year-old Caucasian man presented with a debilitating anogenital lesion.

Differential Diagnosis: The differential diagnosis of anogenital lesions includes infectious (syphilis, herpes simplex virus), noninfectious (hidradenitis suppuritiva, lymphedema), benign (condyloma acuminata), and malignant pathologies (squamous cell carcinoma, Kaposi sarcoma).

Diagnostic Assessment, Management, And Outcome: Biopsy of an anogenital lesion will determine any oncologic potential. Read More

Cancer Res 2020 Aug 9;80(15):3130-3144. Epub 2020 Jun 9.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Kaposi sarcoma is the most common cancer in human immunodeficiency virus-positive individuals and is caused by Kaposi sarcoma-associated herpesvirus (KSHV). It is believed that a small number of latently infected Kaposi sarcoma tumor cells undergo spontaneous lytic reactivation to produce viral progeny for infection of new cells. Here, we use matched donor-derived human dermal blood and lymphatic endothelial cells (BEC and LEC, respectively) to show that KSHV-infected BECs progressively lose viral genome as they proliferate. Read More

Cancer Res 2020 Aug 9;80(15):3116-3129. Epub 2020 Jun 9.

Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Kaposi sarcoma is a tumor caused by Kaposi sarcoma herpesvirus (KSHV) infection and is thought to originate from lymphatic endothelial cells (LEC). While KSHV establishes latency in virtually all susceptible cell types, LECs support spontaneous expression of oncogenic lytic genes, high viral genome copies, and release of infectious virus. It remains unknown the contribution of spontaneous virus production to the expansion of KSHV-infected tumor cells and the cellular factors that render the lymphatic environment unique to KSHV life cycle. Read More

Transpl Infect Dis 2020 Jun 4:e13347. Epub 2020 Jun 4.

Department of Pathology and Laboratory Medicine, UC Davis Health, Sacramento, CA, USA.

Kaposi sarcoma (KS) is a vascular neoplasm caused by human herpesvirus-8 (HHV-8) infection. KS is most often seen in individuals with acquired immunodeficiency syndrome but can occur in patients who are on immunosuppressive therapy. While the skin and oral mucosa are the typical sites for KS, lesions of the tonsil are quite rare with only a few reported cases. Read More

Curr HIV Res 2020 Jun 3. Epub 2020 Jun 3.

Infectious Diseases Department, Instituto Nacional de Cancerología, Mexico City. Mexico.

Background: Disseminated Kaposi sarcoma (DKS) is present in patients with advanced HIV infection in whom co-infection with other opportunistic pathogens can occur. Bone marrow (BM) aspirate and biopsy comprises a robust diagnostic tool in patients with fever, cytopenias, and abnormal liver tests. However, the yield in patients with DKS has not been determined. Read More

Int J STD AIDS 2020 Jul 3;31(8):724-734. Epub 2020 Jun 3.

Baylor College of Medicine Children's Foundation - Tanzania, Mbeya, Tanzania.

In areas of high HIV and human herpes virus 8 prevalence, life-threatening forms of Kaposi sarcoma (KS) can occur in HIV-positive women during pregnancy. Treating KS in pregnancy must balance both the well-being of the mother with the health of the fetus, yet data and recommendations on the best treatment approach for KS during pregnancy are limited. Without effective treatment, which can be difficult to obtain in low income countries (LICs), the mother and infant are at risk for poor outcomes. Read More

Int J Rheum Dis 2020 Jun 1;23(6):828-832. Epub 2020 Jun 1.

The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

We report a rare case of antisynthase syndrome (ASS) complicated with Kaposi sarcoma, analyze its clinical characteristics, and review the literature on the topic. An 80-year-old male patient developed fever, cough, and shortness of breath. Lung high-resolution computed tomography showed nonspecific interstitial pneumonia in both lungs, and myositis antibody examination showed strongly positive anti-alanyl tRNA synthase (PL-12) antibodies. Read More

Int J Surg Pathol 2020 May 27:1066896920917212. Epub 2020 May 27.

National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.

Primary effusion lymphoma is a rare, clinically aggressive large B-cell neoplasm universally associated with human herpesvirus 8 that occurs in the setting of immune compromise. It is classically described as a lymphomatous effusion occurring within body cavities. Recently, however, solid tumor masses, and rarely an intravascular form, have been described. Read More

J Med Virol 2020 May 21. Epub 2020 May 21.

Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Kaposi's sarcoma-associated herpesvirus (KSHV) infection causes several human cancers, including Kaposi's sarcoma (KS), one of the most common AIDS-associated tumors. The involvement of the oral cavity represents one common clinical manifestation of AIDS-KS individuals with periodontal diseases and an oral carriage of a variety of pathogenic bacteria, including Porphyromonas gingivalis. In the current study, we report the clinical relevance of P. Read More

PLoS One 2020 14;15(5):e0233116. Epub 2020 May 14.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States of America.

Kaposi Sarcoma (KS) is among the most angiogenic cancers in humans and an AIDS-defining condition. KS-associated herpesvirus (KSHV) is necessary for KS development, as is vascular endothelial growth factor (VEGF-A). DLX1008 is a novel anti-VEGF-A antibody single-chain variable fragment (scFv) with low picomolar affinity for VEGF-A. Read More

Minerva Med 2020 May 14. Epub 2020 May 14.

Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

Introduction: The incidence of cancer is higher in transplant patients than in the normal population, mostly due to the assumption of immunosuppressants able to reduce the possibility of rejection. In addition, immunocompromised patients have a greater susceptibility to EBV, HPV and HIV, infectious agents that by themselves may favor the onset of malignancies. Post-Transplant Lymphoproliferative Diseases (PLDs) are among the most frequent neoplasms in transplant patients which like other aggressive neoplasms may be identified by the [18f] fluoro-D-deoxyglucose positron emission tomography/computed tomography (FDG- PET/CT). Read More

Actas Dermosifiliogr 2020 May 13. Epub 2020 May 13.

Unidad de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario San Cecilio, Granada, España.

Doxycycline is a synthetic tetracycline that was approved in 1967. This wide-spectrum antibiotic has been shown to also have useful anti-inflammatory properties that make it suitable for the treatment of a number of noninfectious conditions. Tetracyclines are probably the most commonly prescribed antibiotics in dermatology, where they are usually used at doses lower than those effective against infections. Read More

J Am Soc Mass Spectrom 2020 Jul 29;31(7):1422-1439. Epub 2020 May 29.

Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey 08544, United States.

Protein localization is paramount to protein function, and the intracellular movement of proteins underlies the regulation of numerous cellular processes. Given advances in spatial proteomics, the investigation of protein localization at a global scale has become attainable. Also becoming apparent is the need for dedicated analytical frameworks that allow the discovery of global intracellular protein movement events. Read More

Cureus 2020 Apr 8;12(4):e7589. Epub 2020 Apr 8.

Hematology/Oncology, Creighton University Arizona Health Education Alliance/Valleywise Health, Phoenix, USA.

Castleman disease (CD), also known as angiofollicular hyperplasia, is a rare disorder characterized by nonmalignant mediastinal lymph node enlargement provoked by excess interleukin-6 (IL-6) secretion. It could be unicentric or multicentric (MCD). Here, we describe a 27-year-old man with a prior history of AIDS, Kaposi sarcoma (KS), and latent syphilis who presented to the ED for persistent fatigue, fever, chills, night sweats, and productive cough. Read More

Oncotarget 2020 Apr 28;11(17):1556-1572. Epub 2020 Apr 28.

Nebraska Center for Virology, Lincoln, NE, USA.

Despite the close association between Kaposi's sarcoma (KS) and immune dysfunction, it remains unclear whether tumor infiltrating immune cells (TIIC), by their absence, presence, or dysfunction, are mechanistically correlated with KS pathogenesis. Therefore, their potential capacity to serve as prognostic biomarkers of KS disease progression or control is unclear. Because epidemic-KS (EpKS) occurs with HIV-1 co-infection, it is particularly important to compare TIIC between EpKS and HIV-negative African endemic-KS (EnKS) to dissect the roles of HIV-1 and Kaposi Sarcoma-associated herpesvirus (KSHV) in KS pathogenesis. Read More

JAAD Case Rep 2020 May 30;6(5):447-449. Epub 2020 Apr 30.

Department of Dermatology, Stanford University School of Medicine, Stanford, California.

J Cancer Res Ther 2020 Jan-Mar;16(1):177-179

Department of Dermatology, Saham Hospital, Saham, Oman.

Human herpes virus (HHV)-8 is associated with causation of Kaposi's sarcoma (KS). An HIV-positive male with multiple nodules on the body was clinically and histopathologically diagnosed as a case of KS; however, immunohistochemistry was negative for HHV-8. This peculiar scenario of HHV-8-negative tumor with typical clinical and histopathologic findings was labeled as "Atypical spindled endothelial proliferation suspicious of Kaposi sarcoma", hitherto unreported novel entity. Read More