11,884 results match your criteria Kaposi Sarcoma


PPP6C Negatively Regulates STING-Dependent Innate Immune Responses.

mBio 2020 Aug 4;11(4). Epub 2020 Aug 4.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Stimulator of interferon genes (STING) is an essential adaptor protein of the innate DNA-sensing signaling pathway, which recognizes genomic DNA from invading pathogens to establish antiviral responses in host cells. STING activity is tightly regulated by several posttranslational modifications, including phosphorylation. However, specifically how the phosphorylation status of STING is modulated by kinases and phosphatases remains to be fully elucidated. Read More

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http://dx.doi.org/10.1128/mBio.01728-20DOI Listing

Obstructive cholangiopathy patient caused by cytomegalovirus and Kaposi sarcoma in a person living with HIV and hepatitis C.

Int J STD AIDS 2020 Aug 4:956462420943027. Epub 2020 Aug 4.

Infectious Diseases Department, Instituto Nacional de Cancerología, Ciudad de México, Mexico.

We present the case of a 28-year-old man with recently-diagnosed human immunodeficiency virus and hepatitis C virus infection. He developed obstructive cholangiopathy secondary to cytomegalovirus and Kaposi sarcoma, both diagnosed by endoscopic retrograde cholangiopancreatography and biopsies. He received antiretroviral therapy, chemotherapy and valganciclovir with full recovery. Read More

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http://dx.doi.org/10.1177/0956462420943027DOI Listing

Case for diagnosis. Penile lesion in HIV-negative patient.

An Bras Dermatol 2020 Jun 26. Epub 2020 Jun 26.

Dermatology Service, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil.

We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Read More

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http://dx.doi.org/10.1016/j.abd.2020.03.006DOI Listing

An Uncommon Presentation of Extrahepatic Cholestasis due to Single Biliary Stricture From Kaposi Sarcoma.

Cureus 2020 Jun 29;12(6):e8913. Epub 2020 Jun 29.

Gastroenterology and Hepatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

Kaposi sarcoma is one of the acquired immunodeficiency syndrome (AIDS) defining diseases. AIDS-associated Kaposi sarcoma affects primarily the skin and the lungs. Although gastrointestinal involvement is relatively common, biliary tract involvement has rarely been reported. Read More

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http://dx.doi.org/10.7759/cureus.8913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389956PMC

A Rare Case of the Newly Recognized Kaposi Sarcoma Herpesvirus-Associated Disease.

Cureus 2020 Jun 23;12(6):e8784. Epub 2020 Jun 23.

Internal Medicine, Henry Ford Allegiance Health, Jackson, USA.

Kaposi sarcoma herpesvirus (KSHV) is associated with Kaposi sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease (KSHV-MCD) in patients infected with human immunodeficiency virus (HIV). We present a case consistent with a newly recognized KSHV inflammatory cytokine syndrome (KICS), distinct from KSHV-MCD. Although both disorders exhibit signs of substantial inflammation, KICS has minimal lymphadenopathy/splenomegaly and negative pathologic nodal changes in the setting of low CD4 count. Read More

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http://dx.doi.org/10.7759/cureus.8784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381869PMC

Twenty-eight-year incidence and characteristics of post-transplant skin cancers: Comparative analysis of past and recent 10-year experience.

J Dermatol 2020 Jul 28. Epub 2020 Jul 28.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Because primary skin cancers in organ transplant recipients are rare, little is known about the characteristics and risk factors for skin cancers in organ transplant recipients. We searched the Asan Medical Center database of 13 469 organ transplant recipients for cases of all skin cancers from January 1990 to December 2018. Characteristics of and risk factors for skin cancers were analyzed and compared according to the period of transplantation. Read More

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http://dx.doi.org/10.1111/1346-8138.15483DOI Listing

Dangerous Liaisons: Gammaherpesvirus Subversion of the Immunoglobulin Repertoire.

Viruses 2020 Jul 23;12(8). Epub 2020 Jul 23.

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

A common biologic property of the gammaherpesviruses Epstein-Barr Virus and Kaposi sarcoma herpesvirus is their use of B lymphocytes as a reservoir of latency in healthy individuals that can undergo oncogenic transformation later in life. Gammaherpesviruses (GHVs) employ an impressive arsenal of proteins and non-coding RNAs to reprogram lymphocytes for proliferative expansion. Within lymphoid tissues, the germinal center (GC) reaction is a hub of B cell proliferation and death. Read More

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http://dx.doi.org/10.3390/v12080788DOI Listing

Aggressive conjunctival Kaposi sarcoma as the initial manifestation of acquired immunodeficiency syndrome.

Am J Ophthalmol Case Rep 2020 Sep 16;19:100832. Epub 2020 Jul 16.

MedStar Georgetown University Hospital, USA.

Purpose: To report a case of Kaposi sarcoma in a patient with previously undiagnosed Human Immunodeficiency Virus (HIV) infection.

Observations: A 23-year-old male patient presented to the eye clinic with complaints of redness of his left eye for the past month. The patient had been seen one day prior to presentation in the emergency department for a neck mass and pneumonia. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376940PMC
September 2020

Deaths attributable to cancer in the United States HIV population during 2001-2015.

Clin Infect Dis 2020 Jul 25. Epub 2020 Jul 25.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Background: Antiretroviral therapy has reduced mortality among people with HIV, but cancer remains an important cause of death. We characterized cancer-attributable mortality in the US HIV population during 2001-2015.

Methods: We utilized data from population-based HIV and cancer registries in the US. Read More

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http://dx.doi.org/10.1093/cid/ciaa1016DOI Listing

Kaposi sarcoma of the glans: New findings by line field confocal optical coherence tomography examination.

Skin Res Technol 2020 Jul 23. Epub 2020 Jul 23.

Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/srt.12938DOI Listing

Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming Barriers.

JCO Glob Oncol 2020 Jul;6:1134-1146

Center for Global Health, National Cancer Institute, Rockville, MD.

Purpose: The aim of this study was to review the current status of clinical trials for HIV-associated malignancies in people living with HIV in sub-Saharan Africa (SSA) and efforts made by the AIDS Malignancy Consortium (AMC) to build capacity in SSA for HIV malignancy research.

Methods: All malignancy-related clinical trials in 49 SSA countries on ClinicalTrials.gov were reviewed and evaluated for inclusion and exclusion criteria pertaining to HIV status. Read More

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http://dx.doi.org/10.1200/GO.20.00153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392698PMC

Primary Kaposi sarcoma of the glans: A rare case in an HIV-negative patient.

Clin Case Rep 2020 Jul 13;8(7):1134-1137. Epub 2020 Apr 13.

Skin Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.

First presentation of the Kaposi sarcoma (KS) on the penis is not prevalent, and it was reported in 2%-3% of the cases that mostly occurred in the HIV-positive patients. Here, we report a case of primary KS on the glans penis in an HIV-negative patient. Read More

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http://dx.doi.org/10.1002/ccr3.2838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364109PMC

Update on Kaposi sarcoma-associated herpesvirus (HHV8) - review.

Rom J Intern Med 2020 Jul 17. Epub 2020 Jul 17.

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Human herpesvirus 8, also known as Kaposi sarcoma-associated herpesvirus (KSHV), is one of the few pathogens recognized as direct carcinogen, being involved in the pathogenesis of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. KSHV is a relatively recently discovered virus, with still limited possibilities for diagnosis and treatment. Therefore, ongoing studies are trying to answer the main issues related to the management of KSHV infection and its associated diseases. Read More

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http://dx.doi.org/10.2478/rjim-2020-0017DOI Listing

A case of classic Kaposi sarcoma in an immunocompetent human immunodeficiency virus-negative Dominican man.

SAGE Open Med Case Rep 2020 2;8:2050313X20938249. Epub 2020 Jul 2.

Hematology Oncology, The Brooklyn Hospital Center, New York, NY, USA.

Kaposi sarcoma is an uncommon tumor that primarily arises in the skin and mucosal surfaces, but may metastasize to the internal organs. Four main variants of Kaposi sarcoma are recognized as the following: classic Kaposi sarcoma, which occurs in middle-aged or elderly men; epidemic Kaposi sarcoma, associated with human immunodeficiency virus infection; iatrogenic Kaposi sarcoma seen in patients on immunosuppressive drug therapy; and endemic Kaposi sarcoma. This report is of a case of classic Kaposi sarcoma in 55-year-old immunocompetent and human immunodeficiency virus-negative Dominican man who had lived in the United States for 2 years, who presented with a 2-year history of skin lesions on his lower extremities and soft palate. Read More

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http://dx.doi.org/10.1177/2050313X20938249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339073PMC

The Burden of Cutaneous Disease in Solid Organ Transplant Recipients of Color.

Am J Transplant 2020 Jul 13. Epub 2020 Jul 13.

Montgomery Dermatology, Lankenau Institute for Medical Research, King of Prussia, PA, USA.

Organ transplant recipients (OTRs) are at increased risk of cutaneous malignancy. Skin disorders in OTRs of color (OTRoC) have rarely been systematically assessed. We aimed to ascertain the burden of skin disease encountered in OTRoC by prospectively collecting data from OTRs attending two post-transplant skin surveillance clinics: one in London, UK and one in Philadelphia, USA. Read More

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http://dx.doi.org/10.1111/ajt.16210DOI Listing

Cannabidiol for Viral Diseases: Hype or Hope?

Cannabis Cannabinoid Res 2020 Jun 5;5(2):121-131. Epub 2020 Jun 5.

Center for Research in Medical Pharmacology, University of Insubria, Varese, Italy.

The possibility of cannabidiol (CBD) to be used as an antiviral or to treat viral diseases has received limited attention so far, despite the growing number of claims that CBD could be used for the treatment of viral infection-related conditions. Therefore, we systematically retrieved and critically evaluated the scientific literature available on PubMed and the claims on the Internet, to assess the current state of knowledge on the use of CBD in viral diseases, and to provide suggestions for future research directions. PubMed search referenced two original articles supporting the use of CBD for the treatment of hepatitis C and Kaposi sarcoma and one article reporting the ability of CBD to reduce neuroinflammation in a virus-induced animal model of multiple sclerosis. Read More

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http://dx.doi.org/10.1089/can.2019.0060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347053PMC

Rare Ocular Involvement in a Newly Diagnosed AIDS Patient With Diffuse Kaposi's Sarcoma.

Cureus 2020 Jun 8;12(6):e8502. Epub 2020 Jun 8.

Internal Medicine, Methodist Health System, Dallas, USA.

Kaposi's sarcoma (KS) is a cancer that often affects individuals with human immunodeficiency virus, acquired immunodeficiency syndrome (AIDS), those who have received an organ transplant, or others who are immunocompromised. KS is a vascular tumor that most often presents in cutaneous sites, including the lower extremities, oral mucosa, and genitalia. Literature regarding KS with ocular involvement is scarce. Read More

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http://dx.doi.org/10.7759/cureus.8502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346319PMC

Conversion to belatacept maintenance immunosuppression in HIV-positive kidney transplant recipients.

Clin Transplant 2020 Jul 12:e14041. Epub 2020 Jul 12.

Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, USA.

There are only scattered case reports documenting belatacept use in HIV+ kidney transplant recipients. We performed a retrospective review to describe short-term outcomes following conversion to belatacept in a cohort of HIV+ patients. Patients were included if they were converted to belatacept between May 2015-May 2019, had an HIV- donor, and received ≥ 4 doses of belatacept. Read More

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http://dx.doi.org/10.1111/ctr.14041DOI Listing

The potential impacts of early secreted antigenic target of 6 kDa (ESAT-6) of Mycobacterium tuberculosis on KSHV-infected cells.

J Med Virol 2020 Jul 10. Epub 2020 Jul 10.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.

Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human cancers, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), which are mostly seen in immunocompromised patients such as HIV+ individuals. Tuberculosis (TB), caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb), remains one of the deadliest infectious diseases in the world. The risk of developing TB is dramatically higher in people living with HIV than among those without HIV infection. Read More

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http://dx.doi.org/10.1002/jmv.26291DOI Listing

Incidence, prevalence, and outcomes of systemic malignancy with bone metastases.

J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(2):2309499020915989

Department of Orthopedic Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, China.

Purpose: Evidence on the incidence, prevalence, and outcomes of bone metastases among patients with systemic malignancy is limited. This study aimed to evaluate it using the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: We collected patients diagnosed with solid malignant tumors deriving outside of the bone, hematologic malignancies, Kaposi sarcoma, lymphoma, and myeloma from the SEER database (from 2010 to 2013). Read More

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http://dx.doi.org/10.1177/2309499020915989DOI Listing

Kidney transplant patient with Kaposi sarcoma in the left foot.

Arch Esp Urol 2020 Jul;73(6):570-571

Servicio de Anatomía Patológica. Complejo Hospitalario Universitario de Ferrol. Área Sanitaria de Ferrol. SERGAS. Ferrol. A Coruña. España.

53 year old renal transplanted male with secondary amyloidosis to Crohn´sdisease, sent to Dermatology given the presence of multiple red-purple or hyperkeratotic... Read More

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Donor-derived human herpesvirus 8 and development of Kaposi sarcoma among 6 recipients of organs from donors with high-risk sexual and substance use behavior.

Am J Transplant 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

Kaposi sarcoma (KS) can develop following organ transplantation through reactivation of recipient human herpesvirus 8 (HHV-8) infection or through donor-derived HHV-8 transmission. We describe 6 cases of donor-derived HHV-8 infection and KS investigated from July 2018 to January 2020. Organs from 6 donors, retrospectively identified as HHV-8-positive, with a history of drug use disorder, were transplanted into 22 recipients. Read More

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http://dx.doi.org/10.1111/ajt.16181DOI Listing

Residential proximity to an industrial incinerator and risk of soft-tissue sarcoma, 1999-2014.

Epidemiol Prev 2020 Mar-Jun;44(2-3):128-136

Mantova Cancer Registry, Epidemilogy Unit, Agenzia di Tutela della Salute (ATS) della Val Padana, Mantova (Italy).

Background: exposure to dioxins has been associated with an increased risk of soft-tissue sarcoma (STS). In a study relating to 1989-1998, a significant excess of STS was found in the population living within a 2-kilometre radius of an industrial incinerator located inside a Mantua industrial site. In the years 1974-1991, the incinerator burned hazardous chlorine-containing waste that resulted in the emission of dioxins. Read More

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http://dx.doi.org/10.19191/EP20.2-3.P128.035DOI Listing

Unusual presentation of Kaposi sarcoma in an HIV-negative woman.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

The University of Texas MD Anderson Cancer Center, Houston, TX.

Kaposi sarcoma typically presents as violaceous macules and papules in immunocompromised, specifically HIV-positive, patients. Its distinct clinical features often facilitate rapid diagnosis. In this article, we report a case of Kaposi sarcoma presenting as a concerning yet nondescript lesion in an HIV-negative woman. Read More

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Slowly growing plantar mass in a 40-year-old immigrant.

JAAD Case Rep 2020 Jul 11;6(7):625-627. Epub 2020 May 11.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317695PMC

Effects of HIV on the Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1263:45-54

Department of Radiology, Baylor College of Medicine, Houston, TX, USA.

Oncomodulatory viruses can affect the tumor microenvironment (TME) by triggering inflammation, suppressing apoptosis, initiating angiogenesis, altering tumor metabolism, and stimulating tumor cell signaling pathways, leading to tumor growth, proliferation, and invasion. The higher incidence of malignancies among people with HIV (PWH), despite the widespread use of antiretroviral therapy (ART), suggests a more complex relation than HIV-associated immune deregulation. Viral cooperation can have synergistic effect on tumorigenesis. Read More

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http://dx.doi.org/10.1007/978-3-030-44518-8_4DOI Listing

Iatrogenic Penile Kaposi Sarcoma.

Intern Med 2020 Jun 23. Epub 2020 Jun 23.

Division of Rheumatology, Department of Internal Medicine, Okinawa Chubu Hospital, Japan.

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http://dx.doi.org/10.2169/internalmedicine.4751-20DOI Listing

Immunoglobulin E (IgE) Levels are associated with Kaposi's Sarcoma in HIV-Infected African Adults.

J Infect Dis 2020 Jun 19. Epub 2020 Jun 19.

Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, USA.

Recently we demonstrated that activated mast cells (MCs) are enriched in Kaposi sarcoma (KS) tumors and contribute to the inflammatory microenvironment. Mechanisms driving MC activation, however, are incompletely understood. We sought to understand whether Immunoglobulin E (IgE), a potent activator of MCs, was associated with KS incidence and severity. Read More

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http://dx.doi.org/10.1093/infdis/jiaa340DOI Listing
June 2020
5.997 Impact Factor

High-frequency (20 MHz) high-intensity focused ultrasound: New Treatment of actinic keratosis, basal cell carcinoma, and Kaposi sarcoma. An open-label exploratory study.

Skin Res Technol 2020 Jun 17. Epub 2020 Jun 17.

TOOsonix A/S, Horsholm, Denmark.

Background: Skin cancer is common, growing, challenging, and in need of progress in early-stage treatment. 20 MHz high-intensity focused ultrasound (HIFU) is new and applied to actinic keratosis (AK) and skin cancers for the first time. HIFU of lower frequency is already used in the treatment of internal cancers. Read More

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http://dx.doi.org/10.1111/srt.12883DOI Listing

An unusual complication following saphenous vein graft harvesting for coronary artery bypass surgery: Pseudo-Kaposi sarcoma.

Turk Gogus Kalp Damar Cerrahisi Derg 2019 Jun 22;28(2):382-385. Epub 2020 Apr 22.

Department of Pathology, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey.

Pseudo-Kaposi sarcoma is a rare, vasoproliferative skin disease usually caused by an underlying vascular malformation or venous insufficiency. Unusual forms such as amputation stumps and lower extremity paralysis have been also reported. However, its emergence in the leg from which the saphenous vein was harvested following peripheral artery disease and coronary artery bypass surgery has not been previously reported. Read More

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http://dx.doi.org/10.5606/tgkdc.dergisi.2020.19105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298390PMC

Iatrogenic Kaposi sarcoma during tumor necrosis factor alpha inhibitors.

G Ital Dermatol Venereol 2020 Jun 15. Epub 2020 Jun 15.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.23736/S0392-0488.20.06595-5DOI Listing

Allergic contact dermatitis caused by timolol eyedrop application for classic Kaposi sarcoma.

Australas J Dermatol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology, Hospital Universitario de Móstoles, Madrid, Spain.

Topical timolol has been shown to be effective on treatment of Kaposi sarcoma. We present the case of a 72-year-old man with classic Kaposi sarcoma on upper limbs, treated with topical timolol 0.5% twice a day with a pruritic eruption on areas of application. Read More

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http://dx.doi.org/10.1111/ajd.13353DOI Listing

Single Nucleotide Polymorphism Analysis in HIV and Kaposi's Sarcoma Disease by Microarray Technique.

Curr HIV Res 2020 ;18(3):154-164

Faculty of Art and Science, Department of Biology, Harran University, Sanliurfa, Turkey.

Background: Emergence of Kaposi's Sarcoma in the cases other than HIV, following the use of immunosuppressant drugs, demonstrates that it is related to weak immunity. The fact that this malignancy does not occur in every HIV-positive patient suggests that genetic predisposition may also be effective. Replacement of one of the base pairs of adenine, guanine, cytosine, and thymine that constitute the DNA sequence in the human genome with another base pair can affect susceptibility to disease, response to treatment, and immunity. Read More

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http://dx.doi.org/10.2174/1570162X18666200130100654DOI Listing
January 2020

Grand Rounds: Presentation of a Large and Debilitating Fungating Anogenital Lesion.

Urology 2020 Jun 9. Epub 2020 Jun 9.

The Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address:

Case Report: A 65-year-old Caucasian man presented with a debilitating anogenital lesion.

Differential Diagnosis: The differential diagnosis of anogenital lesions includes infectious (syphilis, herpes simplex virus), noninfectious (hidradenitis suppuritiva, lymphedema), benign (condyloma acuminata), and malignant pathologies (squamous cell carcinoma, Kaposi sarcoma).

Diagnostic Assessment, Management, And Outcome: Biopsy of an anogenital lesion will determine any oncologic potential. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.057DOI Listing

The Lymphatic Cell Environment Promotes Kaposi Sarcoma Development by Prox1-Enhanced Productive Lytic Replication of Kaposi Sarcoma Herpes Virus.

Cancer Res 2020 Aug 9;80(15):3130-3144. Epub 2020 Jun 9.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Kaposi sarcoma is the most common cancer in human immunodeficiency virus-positive individuals and is caused by Kaposi sarcoma-associated herpesvirus (KSHV). It is believed that a small number of latently infected Kaposi sarcoma tumor cells undergo spontaneous lytic reactivation to produce viral progeny for infection of new cells. Here, we use matched donor-derived human dermal blood and lymphatic endothelial cells (BEC and LEC, respectively) to show that KSHV-infected BECs progressively lose viral genome as they proliferate. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-19-3105DOI Listing
August 2020
9.329 Impact Factor

Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production.

Cancer Res 2020 Aug 9;80(15):3116-3129. Epub 2020 Jun 9.

Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Kaposi sarcoma is a tumor caused by Kaposi sarcoma herpesvirus (KSHV) infection and is thought to originate from lymphatic endothelial cells (LEC). While KSHV establishes latency in virtually all susceptible cell types, LECs support spontaneous expression of oncogenic lytic genes, high viral genome copies, and release of infectious virus. It remains unknown the contribution of spontaneous virus production to the expansion of KSHV-infected tumor cells and the cellular factors that render the lymphatic environment unique to KSHV life cycle. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-19-3103DOI Listing
August 2020
9.329 Impact Factor

Tonsillar Kaposi sarcoma in a renal transplant patient.

Transpl Infect Dis 2020 Jun 4:e13347. Epub 2020 Jun 4.

Department of Pathology and Laboratory Medicine, UC Davis Health, Sacramento, CA, USA.

Kaposi sarcoma (KS) is a vascular neoplasm caused by human herpesvirus-8 (HHV-8) infection. KS is most often seen in individuals with acquired immunodeficiency syndrome but can occur in patients who are on immunosuppressive therapy. While the skin and oral mucosa are the typical sites for KS, lesions of the tonsil are quite rare with only a few reported cases. Read More

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http://dx.doi.org/10.1111/tid.13347DOI Listing

Bone Marrow Culture Yield for the Diagnosis of Opportunistic Diseases in Patients with AIDS and Disseminated Kaposi Sarcoma.

Curr HIV Res 2020 Jun 3. Epub 2020 Jun 3.

Infectious Diseases Department, Instituto Nacional de Cancerología, Mexico City. Mexico.

Background: Disseminated Kaposi sarcoma (DKS) is present in patients with advanced HIV infection in whom co-infection with other opportunistic pathogens can occur. Bone marrow (BM) aspirate and biopsy comprises a robust diagnostic tool in patients with fever, cytopenias, and abnormal liver tests. However, the yield in patients with DKS has not been determined. Read More

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http://dx.doi.org/10.2174/1570162X18666200603145640DOI Listing

Recommendations for treating life-threatening Kaposi sarcoma during pregnancy in HIV-positive women in low income countries.

Int J STD AIDS 2020 Jul 3;31(8):724-734. Epub 2020 Jun 3.

Baylor College of Medicine Children's Foundation - Tanzania, Mbeya, Tanzania.

In areas of high HIV and human herpes virus 8 prevalence, life-threatening forms of Kaposi sarcoma (KS) can occur in HIV-positive women during pregnancy. Treating KS in pregnancy must balance both the well-being of the mother with the health of the fetus, yet data and recommendations on the best treatment approach for KS during pregnancy are limited. Without effective treatment, which can be difficult to obtain in low income countries (LICs), the mother and infant are at risk for poor outcomes. Read More

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http://dx.doi.org/10.1177/0956462420920160DOI Listing

Anti-alanyl tRNA positive antisynthase syndrome with Kaposi sarcoma.

Int J Rheum Dis 2020 Jun 1;23(6):828-832. Epub 2020 Jun 1.

The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

We report a rare case of antisynthase syndrome (ASS) complicated with Kaposi sarcoma, analyze its clinical characteristics, and review the literature on the topic. An 80-year-old male patient developed fever, cough, and shortness of breath. Lung high-resolution computed tomography showed nonspecific interstitial pneumonia in both lungs, and myositis antibody examination showed strongly positive anti-alanyl tRNA synthase (PL-12) antibodies. Read More

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http://dx.doi.org/10.1111/1756-185X.13861DOI Listing

Kaposi Sarcoma With Intravascular Primary Effusion Lymphoma in the Skin: A Potential Pitfall in HHV8 Immunohistochemistry Interpretation.

Int J Surg Pathol 2020 May 27:1066896920917212. Epub 2020 May 27.

National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.

Primary effusion lymphoma is a rare, clinically aggressive large B-cell neoplasm universally associated with human herpesvirus 8 that occurs in the setting of immune compromise. It is classically described as a lymphomatous effusion occurring within body cavities. Recently, however, solid tumor masses, and rarely an intravascular form, have been described. Read More

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http://dx.doi.org/10.1177/1066896920917212DOI Listing

Porphyromonas gingivalis coinfects with KSHV in oral cavities of HIV+ patients and induces viral lytic reactivation.

J Med Virol 2020 May 21. Epub 2020 May 21.

Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Kaposi's sarcoma-associated herpesvirus (KSHV) infection causes several human cancers, including Kaposi's sarcoma (KS), one of the most common AIDS-associated tumors. The involvement of the oral cavity represents one common clinical manifestation of AIDS-KS individuals with periodontal diseases and an oral carriage of a variety of pathogenic bacteria, including Porphyromonas gingivalis. In the current study, we report the clinical relevance of P. Read More

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http://dx.doi.org/10.1002/jmv.26028DOI Listing

DLX1008 (brolucizumab), a single-chain anti-VEGF-A antibody fragment with low picomolar affinity, leads to tumor involution in an in vivo model of Kaposi Sarcoma.

PLoS One 2020 14;15(5):e0233116. Epub 2020 May 14.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States of America.

Kaposi Sarcoma (KS) is among the most angiogenic cancers in humans and an AIDS-defining condition. KS-associated herpesvirus (KSHV) is necessary for KS development, as is vascular endothelial growth factor (VEGF-A). DLX1008 is a novel anti-VEGF-A antibody single-chain variable fragment (scFv) with low picomolar affinity for VEGF-A. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233116PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224538PMC
May 2020
3.234 Impact Factor

Post Heart Transplantation Lymphoproliferative Diseases (PLDs) and the diagnostic role of [18f] FDG- PET/CT.

Minerva Med 2020 May 14. Epub 2020 May 14.

Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

Introduction: The incidence of cancer is higher in transplant patients than in the normal population, mostly due to the assumption of immunosuppressants able to reduce the possibility of rejection. In addition, immunocompromised patients have a greater susceptibility to EBV, HPV and HIV, infectious agents that by themselves may favor the onset of malignancies. Post-Transplant Lymphoproliferative Diseases (PLDs) are among the most frequent neoplasms in transplant patients which like other aggressive neoplasms may be identified by the [18f] fluoro-D-deoxyglucose positron emission tomography/computed tomography (FDG- PET/CT). Read More

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http://dx.doi.org/10.23736/S0026-4806.20.06607-0DOI Listing
May 2020
1.202 Impact Factor

Doxycycline, an Antibiotic or an Anti-Inflammatory Agent? The Most Common Uses in Dermatology.

Actas Dermosifiliogr 2020 May 13. Epub 2020 May 13.

Unidad de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario San Cecilio, Granada, España.

Doxycycline is a synthetic tetracycline that was approved in 1967. This wide-spectrum antibiotic has been shown to also have useful anti-inflammatory properties that make it suitable for the treatment of a number of noninfectious conditions. Tetracyclines are probably the most commonly prescribed antibiotics in dermatology, where they are usually used at doses lower than those effective against infections. Read More

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http://dx.doi.org/10.1016/j.ad.2019.12.006DOI Listing

TRANSPIRE: A Computational Pipeline to Elucidate Intracellular Protein Movements from Spatial Proteomics Data Sets.

J Am Soc Mass Spectrom 2020 Jul 29;31(7):1422-1439. Epub 2020 May 29.

Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey 08544, United States.

Protein localization is paramount to protein function, and the intracellular movement of proteins underlies the regulation of numerous cellular processes. Given advances in spatial proteomics, the investigation of protein localization at a global scale has become attainable. Also becoming apparent is the need for dedicated analytical frameworks that allow the discovery of global intracellular protein movement events. Read More

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http://dx.doi.org/10.1021/jasms.0c00033DOI Listing

The Potential Clinical Benefit of Tocilizumab Therapy for Patients with HHV-8-infected AIDS-related Multicentric Castleman Disease: A Case Report and Literature Review.

Cureus 2020 Apr 8;12(4):e7589. Epub 2020 Apr 8.

Hematology/Oncology, Creighton University Arizona Health Education Alliance/Valleywise Health, Phoenix, USA.

Castleman disease (CD), also known as angiofollicular hyperplasia, is a rare disorder characterized by nonmalignant mediastinal lymph node enlargement provoked by excess interleukin-6 (IL-6) secretion. It could be unicentric or multicentric (MCD). Here, we describe a 27-year-old man with a prior history of AIDS, Kaposi sarcoma (KS), and latent syphilis who presented to the ED for persistent fatigue, fever, chills, night sweats, and productive cough. Read More

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http://dx.doi.org/10.7759/cureus.7589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212740PMC

Lack of CD8 T-cell co-localization with Kaposi's sarcoma-associated herpesvirus infected cells in Kaposi's sarcoma tumors.

Oncotarget 2020 Apr 28;11(17):1556-1572. Epub 2020 Apr 28.

Nebraska Center for Virology, Lincoln, NE, USA.

Despite the close association between Kaposi's sarcoma (KS) and immune dysfunction, it remains unclear whether tumor infiltrating immune cells (TIIC), by their absence, presence, or dysfunction, are mechanistically correlated with KS pathogenesis. Therefore, their potential capacity to serve as prognostic biomarkers of KS disease progression or control is unclear. Because epidemic-KS (EpKS) occurs with HIV-1 co-infection, it is particularly important to compare TIIC between EpKS and HIV-negative African endemic-KS (EnKS) to dissect the roles of HIV-1 and Kaposi Sarcoma-associated herpesvirus (KSHV) in KS pathogenesis. Read More

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http://dx.doi.org/10.18632/oncotarget.27569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197452PMC

Human herpes virus-8-negative kaposiform sarcoma in a HIV-positive male: Novel variant.

Authors:
Pramod Kumar

J Cancer Res Ther 2020 Jan-Mar;16(1):177-179

Department of Dermatology, Saham Hospital, Saham, Oman.

Human herpes virus (HHV)-8 is associated with causation of Kaposi's sarcoma (KS). An HIV-positive male with multiple nodules on the body was clinically and histopathologically diagnosed as a case of KS; however, immunohistochemistry was negative for HHV-8. This peculiar scenario of HHV-8-negative tumor with typical clinical and histopathologic findings was labeled as "Atypical spindled endothelial proliferation suspicious of Kaposi sarcoma", hitherto unreported novel entity. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_62_17DOI Listing