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    1071 results match your criteria Juvenile Xanthogranuloma Nevoxanthoendothelioma

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    an aggressive multifocal primary CNS histiocytosis with PTPN11 (Shp2) mutation.
    Neuropathol Appl Neurobiol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
    Primary histiocytic tumors of the CNS are rare. The current WHO classification (2016) included 5 entities: Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), Rosai-Dorfman disease (RDD), juvenile xanthogranuloma (JXG), and histiocytic sarcoma (HS) (1). The diagnosis usually is made based on the tumor differentiation as to the counterpart in normal histiocyte development. Read More

    Hemosiderotic Juvenile Xanthogranuloma.
    Am J Dermatopathol 2017 Mar 16. Epub 2017 Mar 16.
    *Department of Cellular Pathology, Hospital El Bierzo, Cellular Pathology, Ponferrada, Spain; †Biomedical Investigation Institute of A Coruña, CellCOM-ST Group, A Coruña, Spain; ‡Department of Cellular Pathology, Hospital de la Reina, Cellular Pathology, Ponferrada, Spain; §Department of Histopathology, Children's Birmingham Hospital, Birmingham, United Kingdom; ¶Department of Histopathology, Birmingham Children's Hospital, Birmingham, United Kingdom; ‖Department of Histopathology, University Children's Hospital, Dublin, Ireland; and **Department of Histopathology, Hospital Niño Jesus, Madrid, Spain.
    Juvenile xanthogranuloma is a non-Langerhans cell lesion mostly limited to the skin but occasionally presenting in extracutaneous locations or associated with systemic conditions. Lesions need to be distinguished mainly from dermatofibroma, xanthoma, Langerhans cell histiocytosis, or reticulohistiocytoma. Herein, we present a hemosiderotic variant of juvenile xanthogranuloma in a 12-year-old girl, which we have not found described in literature. Read More

    [Generalized eruptive histiocytosis-Juvenile xanthogranuloma: clinical spectrum in a pediatric patient].
    Arch Argent Pediatr 2017 Apr;115(2):e116-e119
    Servicio de Dermatología. Hospital del Niño Jesús. San Miguel de Tucumán.
    Both, generalized eruptive histiocytosis and juvenile xanthogranuloma are dendritic histiocytic disorders (also known as non-Langerhans cells histiocytosis) that share clinicopathological and immunohistiochemical characteristics. We present a 3-year-old female patient with skin lesions that were clinically compatible with generalized eruptive histiocytosis, confirmed by histopathological and immunohistochemical studies. During her development the disorder compromised the central nervous system, and surgical intervention of one symptomatic lesion was needed. Read More

    Cutaneous and Systemic Findings in Mosaic Neurofibromatosis Type 1.
    Pediatr Dermatol 2017 Mar 20. Epub 2017 Mar 20.
    Department of Dermatology, Hospital Infantil del Niño Jesús, Madrid, Spain.
    Background/objectives: Mosaic neurofibromatosis type 1 (MNF1) is a variant of neurofibromatosis type 1 (NF1) in which clinical manifestations are limited to one or several body segments. The objective was to characterize the cutaneous features and associated systemic findings in a cohort of children with MNF1.

    Methods: We performed a retrospective study of 40 children diagnosed with MNF1 at the Department of Dermatology, Hospital Infantil Niño Jesús, Madrid, Spain, from January 1, 1986, to October 31, 2015. Read More

    A Rare Case of Solitary Giant Congenital Juvenile Xanthogranuloma.
    J Cutan Med Surg 2017 Feb 1:1203475417690718. Epub 2017 Feb 1.
    3 Hôpital de Maria, Maria, QC, Canada.
    Juvenile xanthogranuloma (JXG) is the most frequent form of non-Langerhans cell histiocytosis. We present a case of giant congenital JXG in a 7-week-old boy, who had a firm and incompressible lesion, measuring 3 × 4 cm in diameter, on his right flank. The clinical appearance of the lesion and the ultrasound results suggested a vascular tumor, such as a hemangioma. Read More

    A Case with Juvenile Xanthogranuloma and Progressive Nodular Histiocytosis Overlap.
    Pediatr Dermatol 2017 Mar;34(2):e102-e103
    Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
    A patient with overlap between juvenile xanthogranuloma and progressive nodular histiocytosis is presented. He had progressive, superficial, small, yellow-reddish papules and large dermal nodules, consistent with progressive nodular histiocytosis. Histopathology showed distinctive features of juvenile xanthogranuloma. Read More

    The relationship between neurofibromatosis type 1, juvenile xanthogranuloma, and malignancy: A retrospective case-control study.
    J Am Acad Dermatol 2017 Feb 8. Epub 2017 Feb 8.
    Section of Pediatric Dermatology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Background: Neurofibromatosis type 1 (NF-1) predisposes individuals to the development of benign and malignant tumors. The association of NF-1, juvenile xanthogranuloma (JXG), and juvenile myelomonocytic leukemia has been described in the literature. It is unclear whether JXG alone constitute a risk factor for leukemia or other malignancies in children with NF-1. Read More

    Association Between Juvenile Myelomonocytic Leukemia, Juvenile Xanthogranulomas and Neurofibromatosis Type 1: Case Report and Review of the Literature.
    Pediatr Dermatol 2017 Mar 23;34(2):114-118. Epub 2017 Jan 23.
    Department of Dermatology, University of Kiel, Kiel, Germany.
    The occurrence of juvenile myelomonocytic leukemia (JMML), juvenile xanthogranuloma (JXG), and neurofibromatosis type 1 (NF1) together is relatively rare. Approximately only 20 cases have been reported in the literature. It is debated whether children with NF1 and JXG are at higher risk of developing JMML than children with NF1 alone. Read More

    [Solitary and congenital juvenile xanthogranuloma: case report].
    Arch Argent Pediatr 2017 02;115(1):e9-e12
    Servicio de Dermatología, Hospital Nacional de Pediatría "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
    Juvenile xanthogranuloma is a bening pathology and it represents the most common form of non-Langerhans cell histiocytosis. It is characterized by the presence of papules or firm nodules of a pinkish or yellow-brownish nature, which mainly compromise the skin and, exceptionally, other organs. It is a self-limited entity having a spontaneous regression during the first five years of life. Read More

    Spectrum of Xanthogranulomatous Processes in the Abdomen and Pelvis: A Pictorial Review of Infectious, Inflammatory, and Proliferative Responses.
    AJR Am J Roentgenol 2017 Mar 17;208(3):475-484. Epub 2017 Jan 17.
    3 Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030.
    Objective: Xanthogranulomatous (XG) processes are rare inflammatory conditions with the characteristic pathologic feature of lipid-laden macrophages or histiocyte cells. Imaging findings are nonspecific and can simulate aggressive neoplastic processes. XG processes can be caused by infection, inflammation, histolytic process, or an inherited lysosomal disorder. Read More

    Juvenile Xanthogranuloma in Vulva of a 10-Year-Old Child.
    J Clin Diagn Res 2016 Nov 1;10(11):ED21-ED22. Epub 2016 Nov 1.
    Professor, Department of Surgery, Madan Mohan Malviya Hospital , New Delhi, India .
    A 10-year-old child presented with asymptomatic, well-circumscribed nodule in the vulva. Excision biopsy showed features of classic Juvenile Xanthogranuloma (JXG) which is a rare benign disorder of non-langerhans' cell group of histiocytic proliferative diseases. The presentation of this lesion as vulval nodule is extremely rare and the extensive literature search revealed only handful of cases of vulval xanthogranuloma that too in an adult age group. Read More

    Eruptive xanthogranuloma in a healthy adult male.
    J Cutan Pathol 2017 Apr 16;44(4):385-387. Epub 2017 Jan 16.
    Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
    Xanthogranuloma is a benign, non-Langerhans cell histiocytosis primarily diagnosed in infants and children, although a subset occurs in adults. Multifocal eruptive presentation of xanthogranuloma is very rare with only 4 previous cases reported in the literature to our knowledge. We describe a case of eruptive xanthogranuloma in a 49-year-old man who presented with sudden onset of numerous asymptomatic, red-yellow to orange papules on the face, scalp, axilla, flank and scrotum. Read More

    The World Health Organization 2016 classification of testicular non-germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel.
    Histopathology 2017 Mar 23;70(4):513-521. Epub 2016 Dec 23.
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification, and incorporated the most up-to-date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of germ cell tumours; however, several modifications were also made for non-germ cell tumours. Read More

    Contributions of Dr. Louis "Pepper" Dehner to the art of cutaneous pathology, the first pediatric dermatopathologist.
    Semin Diagn Pathol 2016 Nov 5;33(6):441-449. Epub 2016 Sep 5.
    Department of Pathology & Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
    Dr. Louis "Pepper" Dehner has been one of the most influential surgical pathologists of the last century. Authoring more than 450 publications, he is the premier modern pediatric pathologist. Read More

    Histiocytic proliferations.
    Semin Diagn Pathol 2016 Nov 1;33(6):396-409. Epub 2016 Sep 1.
    Department of Pathology, Children׳s Hospital of Pittsburgh of UPMC, 4401 Penn Ave (Suite B260), Pittsburgh, Pennsylvania. Electronic address:
    The study of Histiocytic lesions has been a passion of Pepper Dehner over the years. He has contributed several case series and reviews on various categories of these diseases for over 4 decades, with his earliest articles in the 1970s. He has written on all aspects of the disease including seminal articles on Langerhans cell histiocytosis (LCH) and their prognostic features, his experiences with regressing atypical histiocytosis, his encounters with malignant histiocytosis, and classic articles on juvenile xanthogranuloma. Read More

    Cardiothoracic manifestations of primary histiocytoses.
    Br J Radiol 2016 Dec 26;89(1068):20160347. Epub 2016 Sep 26.
    5 Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    The objectives of this article were: (1) to review common and rare manifestations of systemic and pulmonary Langerhans cell histiocytosis, Rosai-Dorfman disease, Erdheim-Chester disease and juvenile xanthogranuloma; (2) to provide the reader with important pathologic, epidemiologic and clinical features of these diseases. The histiocytoses are a diverse group of diseases which typically manifest with multiorgan involvement. Understanding the pathologic, epidemiologic and clinical features of these entities can help the radiologist suggest an accurate diagnosis of histiocytosis when typical imaging features are encountered. Read More

    New Ultrasound Biomicroscopy Iris Findings in Juvenile Xanthogranuloma.
    J Glaucoma 2016 Aug;25(8):e759-60
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.
    We report a case of juvenile xanthogranuloma in a 12-month-old girl presenting with heterochromia, hyphema, and elevated intraocular pressure. This case demonstrates new ultrasound biomicroscopy iris findings of a generalized bumpy iris contour, suggesting diffuse heterogeneous involvement. This imaging finding has not been previously described. Read More

    Elevated taurine and glutamate in cerebral juvenile xanthogranuloma on MR spectroscopy.
    Brain Dev 2016 Nov 18;38(10):964-967. Epub 2016 Jul 18.
    Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan. Electronic address:
    MRI in a 2-year-old female presenting afebrile seizures and left blepharoptosis revealed multiple well-marginated round-shaped lesions, isointensity to gray matter on T1- and T2-weighted images with homogenously reduced diffusion and diffuse contrast enhancement. MRS revealed elevation of taurine, choline and glutamate, and reduction of N-acetylaspartate. A brain biopsy confirmed a diagnosis of juvenile xanthogranuloma (JXG). Read More

    Juvenile Xanthogranuloma: Presenting as an Isolated Renal Involvement.
    Fetal Pediatr Pathol 2016 1;35(6):420-424. Epub 2016 Jul 1.
    a Histopathology , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
    Juvenile xanthogranuloma (JXG) is a histiocytic disorder of childhood that mostly affects the skin although extracutaneous and visceral manifestations are well documented in English literature. The renal involvement is less commonly documented as a manifestation of xanthogranuloma and the reported cases occur in conjunction with cutaneous xanthogranuloma, especially in association with multiple skin lesions. We present a case of isolated renal JXG presenting as a renal mass with perinephric soft tissue and muscle involvement but without any cutaneous manifestation. Read More

    Conjunctival fibrous histiocytoma in an 8-year-old boy.
    J AAPOS 2016 Aug 7;20(4):368-70. Epub 2016 Jun 7.
    Department of Ophthalmic Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    An 8-year-old healthy boy underwent surgery for excision of a painless, enlarging vascularized conjunctival tumor. Histopathology disclosed a mass comprised of interweaving spindle cells and scattered histiocytes in a fibrous matrix, consistent with benign fibrous histiocytoma. This rare tumor can resemble several conditions, including scleritis/episcleritis, inflamed pterygium, juvenile xanthogranuloma, foreign body granuloma, solitary fibrous tumor, amelanotic melanoma, and squamous cell carcinoma. Read More

    The clinical diagnosis and management options for intracranial juvenile xanthogranuloma in children: based on four cases and another 39 patients in the literature.
    Acta Neurochir (Wien) 2016 Jul 13;158(7):1289-97. Epub 2016 May 13.
    Department of pediatric Neurosurgery, Xinhua hospital, Shanghai Jiao Tong University, Shanghai, 200092, China.
    Background: Juvenile xanthogranulomas (JXGs) are uncommon non-Langerhans cell histiocytic proliferations which occur most often in children. Rare cases of intracranial JXGs in children have been reported. The precise treatment strategy for intracranial JXG with high fatality is still unclear. Read More

    Atypical Fibroxanthoma in a 13-Year-Old Guatemalan Girl with Xeroderma Pigmentosum.
    Pediatr Dermatol 2016 May 4;33(3):e228-9. Epub 2016 Apr 4.
    Comprehensive Dermatology Group, Encinitas, California.
    Xeroderma pigmentosum (XP) is a rare, autosomal recessive disease involving a defect in DNA repair leading to the premature development of numerous aggressive cutaneous malignancies. Although atypical fibroxanthoma (AFX) is a neoplasm typically found in the setting of extensive sun exposure or therapeutic radiation, AFXs are rarely associated with children with XP. We report the case of a 13-year-old Guatemalan girl with the XP type C variant who developed one of the largest AFXs reported on a child's finger. Read More

    Giant molluscum contagiosum presenting as lid neoplasm in an immunocompetent child.
    Dermatol Online J 2016 Jan 15;22(1). Epub 2016 Jan 15.
    Medical Research Foundation, Sankara Nethralaya, Chennai.
    A three-year-old boy presented to our oculoplastic clinic with complaints of painless gradually increasing right upper lid mass for the last 6 months. On examination a firm mass measuring roughly 1x1 cm was present on the upper lid. The mass was non tender with fine superficial vessels running over it. Read More

    Histiocytosis with mixed cell populations.
    J Cutan Pathol 2016 May 4;43(5):456-60. Epub 2016 Apr 4.
    Department of Pathology, Hospital Clínico Universitario, Valencia, Spain.
    Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. We describe an exceptional case of multiple cutaneous lesions in a 10-year-old boy, in which the coexistence of both LCH and JXG cell populations is found in every single lesion. The presence of Birbeck granules and CD207 (langerin) immunostaining in the LCH component would argue against the diagnosis of indeterminate cell histiocytosis (ICH). Read More

    Successful treatment with cladribine of Erdheim-Chester disease with orbital and central nervous system involvement developing after treatment of Langerhans cell histiocytosis.
    Vojnosanit Pregl 2016 Jan;73(1):83-7
    Introduction: Erdheim-Chester disease (ECD) is a rare, systemic form of non-Langerhans cell histiocytosis of the juvenile xanthogranuloma family with characteristic bilateral symmetrical long bone osteosclerosis, associated with xanthogranulomatous extra skeletal organ involvement. In ECD, central nervous system (CNS) and orbital lesions are frequent, and more than half of ECD pa tients carry the V600E mutation of the protooncogene BRAF. The synchronous or metachronous development of ECD and Langerhans cell histiocytosis (LCH) in the same patients is rare, and the possible connection between them is still obscure. Read More

    An Update on Neurofibromatosis Type 1: Not Just Café-au-Lait Spots and Freckling. Part II. Other Skin Manifestations Characteristic of NF1. NF1 and Cancer.
    Actas Dermosifiliogr 2016 Jul-Aug;107(6):465-73. Epub 2016 Mar 5.
    Servicio de Neurología, Hospital Infantil del Niño Jesús, Madrid, España.
    Neurofibromatosis type 1 (NF1) is the most common neurocutaneous syndrome and probably the one best known to dermatologists. Although the genetic locus of NF1 was identified on chromosome 17 in 1987, diagnosis of the disease is still based primarily on clinical observations. The 7 diagnostic criteria of the National Institutes of Health, which were established in 1988, include 3 skin manifestations (café-au-lait spots, freckling on flexural areas, and cutaneous neurofibromas). Read More

    Hair Follicle Nevus with Sebaceous Hyperplasia: A Dermoscopic Observation.
    Case Rep Dermatol 2015 Sep-Dec;7(3):358-62. Epub 2015 Dec 23.
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
    We herein report a case of hair follicle nevus, a rare hamartoma found on the face and showing follicular differentiation, which was associated with sebaceous hyperplasia. Dermoscopy of the lesion showed yellow globules surrounded by crown vessels/telangiectasias and scattered tiny hairs. Histopathological investigation revealed hyperplasia of the sebaceous glands and proliferation of well-differentiated vellus hair follicles. Read More

    Corneal xanthogranuloma in association with multiple endocrine neoplasia 1: A clinicopathologic case report and review of the literature.
    Saudi J Ophthalmol 2016 Jan-Mar;30(1):49-52. Epub 2015 Nov 25.
    Alfaisal University, Riyadh, Saudi Arabia; Al-Magrabi Hospital, Riyadh, Saudi Arabia.
    Juvenile xanthogranuloma (JXG) is a benign inflammatory condition of uncertain pathogenesis. It is characterized by skin and ocular involvement - typically in the iris - in children. It has been reported in older age groups and has been also observed to involve other ocular structures such as the cornea and conjunctiva. Read More

    The epidemiology, clinical characteristics, histopathology and management of juvenile- and adult-onset corneoscleral limbus xanthogranuloma.
    Graefes Arch Clin Exp Ophthalmol 2016 Mar 21;254(3):413-20. Epub 2016 Jan 21.
    Pathology, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK.
    Purpose: Adult-onset xanthogranuloma (AOX) of the corneoscleral limbus is a rare inflammatory condition of unknown aetiology. Similar to limbal juvenile xanthogranuloma (JXG), it presents as a growing mass at the corneoscleral junction. Limbal AOX and JXG can lead to sight-threatening complications if not managed in a timely manner. Read More

    Imaging Features of Juvenile Xanthogranuloma of the Pediatric Head and Neck.
    AJNR Am J Neuroradiol 2016 May 7;37(5):910-6. Epub 2016 Jan 7.
    From the Departments of Radiology (D.T.G., V.M.S., C.D.R.) Harvard Medical School (S.O.V., V.M.S., M.S.V., B.A.D., C.D.R.), Boston, Massachusetts.
    Background And Purpose: Juvenile xanthogranuloma is a non-Langerhans cell histiocytosis primarily affecting children. The purpose of this study was to characterize the imaging features of histologically confirmed pediatric head and neck juvenile xanthogranuloma.

    Materials And Methods: A retrospective review was performed of medical records and imaging of histologically confirmed head and neck juvenile xanthogranuloma. Read More

    Coalescing nodules on the trunk of an infant: juvenile xanthogranuloma 'en plaque'.
    Dermatol Online J 2016 Oct 15;22(10). Epub 2016 Oct 15.
    Department of Medicine, Division of Dermatology, University of California Los Angeles (UCLA), Los Angeles, California.
    Juvenile xanthogranuloma (JXG) is a benign, non-Langerhans cell histiocytosis, which commonly manifests as a solitary papule or nodule in infants and young children. However, other less common clinical presentations have been reported including clustered, agminated or plaque-like. It is important to recognize these variants, as diagnosis is often clinical. Read More

    Radiographic and Pathologic Manifestations of Uncommon and Rare Pulmonary Lesions.
    Can Assoc Radiol J 2016 May 11;67(2):179-89. Epub 2015 Dec 11.
    Department of Radiology, Yale New Haven Hospital, New Haven, Connecticut, USA.
    Pulmonary opacities/nodules are common findings on computed tomography examinations, which may represent an underlying infections or malignancy. However, not every pulmonary nodule or opacity represents malignancy or infection. We present a pictorial essay illustrating common as well as obscure noninfectious, nonmalignant pulmonary lesions. Read More

    Uncommon histiocytic disorders: Rosai-Dorfman, juvenile xanthogranuloma, and Erdheim-Chester disease.
    Hematology Am Soc Hematol Educ Program 2015 ;2015:571-8
    Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
    Rosai-Dorfman disease (RDD), juvenile xanthogranuloma (JXG), and Erdheim-Chester disease (ECD) are non-Langerhans cell (non-LCH) disorders arising from either a dendritic or a macrophage cell. RDD is a benign disorder that presents with massive lymphadenopathy, but can have extranodal involvement. In most cases, RDD is self-limited and observation is the standard approach. Read More

    Biological and clinical significance of somatic mutations in Langerhans cell histiocytosis and related histiocytic neoplastic disorders.
    Hematology Am Soc Hematol Educ Program 2015 ;2015:559-64
    Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX; Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; and Division of Pediatric Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
    Langerhans cell histiocytosis (LCH), juvenile xanthogranuloma (JXG), and Erdheim-Chester disease (ECD) represent histiocytic disorders with a wide range of clinical manifestations. Until recently, mechanisms of pathogenesis have been speculative and debate has focused on classification of these conditions as reactive versus neoplastic. Genomic studies have been challenged by scarce tissue specimens, as well as heterogeneous nature of the lesions with variable infiltration of pathologic histiocytes. Read More

    Color Doppler Sonography of Cutaneous Juvenile Xanthogranuloma With Clinical and Histologic Correlations.
    J Ultrasound Med 2016 Jan 3;35(1):212-3. Epub 2015 Dec 3.
    Department of Dermatology (S.N.), School of Medicine (I.N.), Department of Pathology (S.G.), Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile, Departments of Radiology and Dermatology (X.W.), Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Clinica Servet, Faculty of Medicine, University of Chile, Santiago, Chile.

    Pseudoangiomatous xanthelasmoid mastocytosis: two case reports showing the hypervascularity of this rare variant of cutaneous mastocytosis.
    J Cutan Pathol 2016 Apr 8;43(4):388-93. Epub 2015 Dec 8.
    Department of Pathology, hôpital Necker-Enfants Malades, APHP, Paris, France.
    Xanthelasmoid mastocytosis or xanthelasmoidea is a rare clinical variant of cutaneous mastocytosis characterized by a yellow hue of the clinical lesions, which are often misdiagnosed as juvenile xanthogranuloma. We present two pediatric cases of xanthelasmoid mastocytosis presenting as isolated mastocytomas, which are notable histopathologically for their hypervascularity. This pseudoangiomatous variant of cutaneous mastocytosis is important for pathologists to have knowledge of, so that a diagnosis of a vascular tumor is not rendered accidentally. Read More

    Nosology and Pathology of Langerhans Cell Histiocytosis.
    Hematol Oncol Clin North Am 2015 Oct;29(5):799-823
    Department of Pathology, Magee-Womens Hospital of UPMC, University of Pittsburgh School of Medicine, 300 Halket St., Pittsburgh, PA 15213, USA.
    The classification of the histiocytoses has evolved based on new understanding of the cell of origin as a bone marrow precursor. Although the pathologic features of the histiocytoses have not changed per se, molecular genetic information now needs to be integrated into the diagnosis. The basic lesions of the most common histiocytoses, their patterns in different sites, and ancillary diagnostics are now just one part of the classification. Read More

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